KR20140069908A - Composition for promoting health of eyes - Google Patents

Abstract

The present invention relates to a composition comprising a ginseng fruit extract as an active ingredient which provides overall health benefits of the eye by alleviating symptoms of eye fatigue, tightness, dryness, pain, and itching. The composition according to the present invention has an excellent effect of promoting eye health and can effectively alleviating fatigue of the eyes by comprising the extract of ginseng fruit.

Description

[Composition for promoting health of eyes]

Described herein is the novel use of ginseng fruit for human health.

Ginseng (Panax ginseng CA Meyer) is a herb that has been used in Korea, China and Japan for over 2,000 years. It has been used for the purpose of preventing diseases and prolonging life span by empirical methods. The efficacy and effect of ginseng is improved by the action on the central nervous system, anti-carcinogenic action, anti-cancer activity action, immunity function control action, anti-diabetic action, liver function enhancement effect, cardiovascular disorder improvement, anti-arteriosclerosis action, blood pressure control action, , Antioxidant activity, antioxidant activity, antioxidant activity, and the like are known (Recent Ginseng "Ingredients and Efficacy", Korea Ginseng & Tobacco Research Institute, 56-112, 1996).

Ginsenoside, which is a representative physiologically active ingredient of ginseng, is distributed evenly on the ground and underground of ginseng. Depending on the parts such as ginseng roots, ginseng leaves, and ginseng fruit, not only ginsenoside content but also composition is different (Attele AS et al, Biochem Pharmacol, 58: 1685-1693, 1999).

However, studies on specific ingredients and eye health in ginseng fruit are insufficient.

Korean Patent Laid-Open No. 10-2008-0094540

Attele AS et al, Biochem Pharmacol, 58; 1685-1693, 1999 Dey L. et al., Phytomedicine, 10; 600-605, 2003 Nat. Prod. REP., 2009, 26, 1001-1043 Asia Pac J Clin Nutr. 2007; 16 (2): 200-208

The present invention relates to a composition containing a ginseng fruit having a novel use for human health, and to provide a composition for promoting overall eye health.

In order to achieve the above-mentioned object, an embodiment of the present invention provides a composition for improving eye health comprising an extract of ginseng fruit as an active ingredient.

It is another object of the present invention to provide a composition for improving eye fatigue comprising ginseng fruit extract.

The composition according to the present invention is excellent in improving the eye health by containing the ginseng fruit extract and can effectively improve the eye fatigue.

In addition to improving eye health, it can improve the health of the human body as a whole by improving fatigue, providing mental stability, improving skin condition, improving limb comfort, and alleviating menopausal symptoms.

Accordingly, the composition according to the present invention can be used in various fields in food and medicine fields.

1 is a graph showing the results of analysis of ginsenoside components of ginseng root extract according to an embodiment of the present invention and a comparative example thereof.
FIG. 2 is a graph showing the overall eye health improvement of ginseng fruit extract according to one embodiment of the present invention.

Hereinafter, the present invention will be described in detail.

One embodiment of the present invention provides a composition for enhancing eye health comprising an extract of ginseng fruit as an active ingredient.

The ginseng fruit is a part of ginseng, and the type and content composition of ginseng root (root), which is commonly used, is different.

Specifically, the ginseng fruit contains more minerals such as vitamins than ginseng root. In addition, the ginseng fruit contains more ginsenoside than the ginseng root, and the composition of the ginsenoside contained is different. In one embodiment of the present invention, the ginseng fruit extract is a ginsenoside PT (Protopanaxatriol) system including ginsenosides Re, Rg1, Rg2, etc., with ginsenosides Rb1, Rb2, Rc, PD (Protopanaxadiol) system, and thus can exhibit different effects. For example, ginseng fruit has been reported to have superior antidiabetic efficacy than ginseng root (Dey L. et al., Phytomedicine, 10; 600-605, 2003).

In addition, the fruit of the ginseng becomes greenish in the green like leaf, and the flesh turns into red or yellow depending on the kind. As the color of the flesh changes, anthocyanin is formed in the ginseng fruit. Anthocyanins include, for example, cyanidin chloride, delphinidin chloride, malvidin chloride, pelargonin chloride, cyanin chloride, ideine chloride, Keracyanin chloride, kuromanin chloride, pelagonidin chloride, petunidin chloride, etc. (Nat. Prod. REP., 2009, 26,1001-1043). And anthocyanins are effective for antioxidant, antiallergic, anti-inflammatory, antiviral, antiproliferative, antimutagenic, antimicrobial, anticarcinogenic, cardiovascular and allergic protection, microcirculation protection, peripheral capillary resistance protection, (Asia Pac J Clin Nutr 2007; 16 (2): 200-8).

Accordingly, the composition according to one embodiment of the present invention can contain vitamins, minerals, ginsenosides, anthocyanins and the like as described above, so that the ginseng fruit extract can improve the eye health, .

Anthocyanin can bind to rhodopsin, a protein that senses red light contained in rod-like cells in the retina of the eye, and can be used in phototransduction processes of phosphodiesterase (PDE) , Which can improve night vision and improve eye health (Asia Pac J Clin Nutr 2007; 16 (2): 200-208).

In addition, according to one embodiment of the present invention,

(a) pretreating the fruit of ginseng; and

(b) extracting the ginseng fruit pretreated in the above step with water or an organic solvent to obtain a ginseng fruit extract.

In step (a), the ginseng fruit may be three-diarrhea per day, and the flesh and skin of the ginseng fruit may be dried through daylight drying or hot air drying.

In step (b), the ginseng fruit extract may be prepared by extracting dried ginseng fruit with water or an organic solvent under reflux at room temperature, and then concentrating the extract under reduced pressure.

The composition according to an embodiment of the present invention may contain 0.01 to 100% by weight of ginseng fruit extract, based on the total weight of the composition, depending on the form of the composition.

In addition, the composition according to another embodiment of the present invention may be formulated as a pharmaceutical composition or a food composition in the form of tablets, pills, tablets, capsules, granules, powders, ointments, drinks or injections.

The present invention provides, as an embodiment, a pharmaceutical composition containing a ginseng fruit extract according to a conventional method. In the manufacture of pharmaceutical formulations, it is preferred that the active ingredient is mixed with or diluted with the carrier, or enclosed within a carrier in the form of a container. When the carrier is used as a diluent, it may be a solid, semi-solid or liquid substance acting as a carrier, excipient or medium for the active ingredient. Thus, the formulations may be in the form of tablets, pills, powders, sachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols, soft or hard gelatin capsules, sterile injections, sterile powders and the like.

Examples of suitable carriers, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, Hydroxybenzoate, talc, magnesium stearate, and mineral oil. The formulations may additionally include fillers, anti-coagulants, lubricants, wetting agents, perfumes, emulsifiers, preservatives, and the like. The compositions of the present invention may be formulated using methods well known in the art so as to provide rapid, sustained or delayed release of the active ingredient after administration to the mammal.

The pharmaceutical composition of the present invention may be administered through various routes including oral, transdermal, subcutaneous, intravenous, intraperitoneal, muscle, topical application, patch and iontophoresis, and local application and oral administration are preferred Do.

In the case of humans, the usual daily dose of the active compound may range from 1 to 100 mg / kg body weight, preferably from 5 to 70 mg / kg body weight, and may be administered in single or divided doses. It should be understood, however, that the actual dosage of the active ingredient should be determined in light of various relevant factors such as the disease to be treated, the route of administration, the age, sex and weight of the patient, and the severity of the disease, Are not intended to limit the scope of the invention.

In addition, the present invention provides, as an embodiment, a food composition containing a ginseng fruit extract according to a conventional method.

The food composition of the present invention has a liquid or solid form, and the formulation is not particularly limited. For example, it may be formulated into tablets, granules, drinks, caramels, diabas, and the like. The food composition of each formulation can be blended with the ingredients commonly used in the field in addition to the active ingredient without difficulty by those skilled in the art depending on the purpose of formulation or use, and synergistic effect can be obtained when the composition is applied simultaneously with other ingredients.

Hereinafter, the present invention will be described with reference to the following examples and test examples. The examples and the test examples are for illustrating the present invention in more detail, and the scope of the present invention is not limited to the range of the following examples.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the scope of the invention.

[Example 1] Preparation of ginseng fruit extract

Ginseng fruit pretreatment

The raw ginseng fruit was harvested and the seeds were separated and removed. Then, the ginseng fruit and the skin of the ginseng fruit were dried with sunshine or hot air to prepare dry ingredients of ginseng fruit.

Manufacture of ginseng fruit extract

3 kg of water or alcohol (ethanol) was added to 1 kg of dried ginseng fruit, and the mixture was refluxed at room temperature, filtered and concentrated under reduced pressure at 40 to 45 ° C to obtain 300 g of ginseng fruit extract.

[Comparative Example 1] Production of ginseng muscle root extract

Example 1 was prepared in the same manner as in Example 1, except that ginseng root (root) was used instead of ginseng fruit.

[Test Example 1] Comparison of components of ginseng fruit extract

<Analysis of Ginseng Saponin Components of Ginseng Fruit and Ginseng Root>

The ginseng fruit of Example 1 and the ginseng muscle extract of Comparative Example 1 according to one embodiment of the present invention were each prepared, and then the ether was treated to remove the fat-soluble components and then the crude saponin Was extracted and concentrated to analyze the ginsenoside components via HPLC. The results are shown in FIG. 1 and Table 1 below.

Example 1 (Ginseng fruit extract) Comparative Example 1 (Ginseng root extract) Crude saponin content (dry weight) 33.42% 16.70% PD / PT ratio 0.73 3.23

As a result of the analysis, as shown in FIG. 1 and Table 1, the ginseng fruit extract prepared in Example 1 had about twice the crude saponin content than the ginseng root extract prepared in Comparative Example 1.

The content ratio of ginsenosides was 0.73 and 3.23, respectively, when the ratio of protopanaxadiol-ginsenosides Rb1, Rb2, Rc and Rd and PT (Protopanaxatriol) -ginsenoside Re, Rg1 and Rg2 was The composition and contents of ginsenosides contained in the ginseng fruit and ginseng root showed opposite characteristics. In addition, the ginseng fruit extract contained about 9 times more ginsenoside Re than Ginseng root extract.

<Mineral composition analysis of ginseng fruit extract>

The ginseng fruit extract prepared in Example 1 was analyzed for minerals including vitamins in order to distinguish it from "ginseng" which is different from ginseng. The results are shown in Table 2 below.

ingredient Fruit content Root content ingredient Fruit content Root content Potassium (mg / 100g) 5865.57 1460 Magnesium (mg / 100 g) 354.38 160 Calcium (mg / 100g) 819.26 340 Zinc (mg / 100g) 178.49 1.961 Iron (mg / 100g) 59.31 9.804 Vit. A (ug / 100 g, RE) 213.11 - Phosphorus (mg / 100 g) 187.17 340 Vit.B1 (mg / 100g) 12.29 0.16 Vit.B2 (mg / 100g) 8.45 0.50 Vit.B6 (mg / 100g) 10.50 - Vit. C (mg / 100g) 4.91 6 Vit.E (mg / 100 g, a-TE) 23.61 - Vit. K (占 퐂 / 100 g) 232.12 - Niacin (mg / 100 g, NE) 5.76 1.0 Pantothenic acid (mg / 100g) 5.87 0.66 Folate (㎍ / 100g) 349.97 -

As shown in Table 2, the ginseng fruit according to one embodiment of the present invention is rich in 16 kinds of vitamins and minerals in general, unlike the ginseng root.

As described above, the ginseng fruit according to one embodiment of the present invention contains more ginseng saponin than the ginseng root and has the opposite properties of the saponin composition. Also, unlike the ginseng root, the content of 16 kinds of vitamins and minerals I could confirm this richness.

<Analysis of anthocyanin components of ginseng fruit extract>

Anthocyanin components contained in the ginseng fruit extract of Example 1 prepared according to one embodiment of the present invention were quantitatively analyzed.

At this time, an anthocyanidin kit (cyanidin chloride, delpidine hydrochloride, malbidin chloride, pelarone chloride), cyanidin derivative kit (cyanidin chloride, cyanine chloride, ideine chloride, ), Ferragonidine chloride, and fetudinidine chloride standards. The results are shown in Table 3. The results are shown in Table 3.

Analysis Item Unit: ppm (ug / g) Ginseng fruit extract Malvidin chloride 12.17 The idea of cyanidin-3-O-galactoside 2.36 Ferargonidine chloride 8.28 Keracine chloride 3.29 Sum 26.1

As shown in Table 3, the amounts of malvidin chloride, ide phosphoryl chloride, ferulenin chloride and kerocyanine chloride were determined to be 12.17, 2.36, 8.28 and 3.29 ppm, respectively, and the sum of the four components was 26.1 ppm, indicating that anthocyanin was abundantly contained.

 [Test Example 2] Evaluation of eye health improvement

Based on the results of Test Example 1, the change of the eye health index when the composition containing the ginseng fruit extract was directly applied to the human body was observed and evaluated according to one embodiment of the present invention. In other words, changes in eye health before and after consumption of ginseng fruit extract were evaluated by the following methods.

For the experiment, 700 mg tablets containing 100% by weight of the ginseng fruit extract of Example 1 were prepared. At this time, the tablet was tableted using a single-handed tableting machine (ERWEKA, Germany).

Then, the tablets containing the above ginseng fruit extract were administered to 58 persons in 10 to 50 years old men and women for 2 weeks, twice a day for 4 weeks. That is, standardized ginseng fruit extract was taken at 1400 mg per day.

 At the same time, we surveyed the overall eye health index before and after ingestion by the following method.

There are 19 symptoms of eye related discomfort that I usually feel as tiredness, pressure, eyelid fatigue, tear flow, fever, dry feeling, pain, tickling, eyelid convulsion, afterimage, glare, (1-15 points) for each symptom of fatigue, burning sensation, and focus adjustment time. 15 points for very uncomfortable, and 1 point for no discomfort. The results are shown in Table 4 and Figure 2 (N = 58) as a change in the eye health self-diagnosis score before and after ingestion of the ginseng fruit extract.

Item range Before ingestion
Mean ± SD After ingestion
Mean ± SD Fatigue 1 to 15 10.5 ± 1.56 5.4 ± 1.86 Pressure 1 to 15 8.7 ± 0.22 6.2 ± 0.78 Eyelid (eyelid) fatigue 1 to 15 13.5 ± 1.79 4.2 ± 0.71 Tear flow 1 to 15 11.1 ± 0.26 6.7 ± 0.97 Fever 1 to 15 9.3 ± 1.61 5.4 ± 1.11 Dry feeling 1 to 15 12.8 ± 0.46 4.7 ± 0.85 ache 1 to 15 5.5 ± 0.12 4.5 ± 0.63 Tickle 1 to 15 6.7 ± 1.55 3.7 ± 1.36 Eyelid (seizure) eyelid 1 to 15 8 ± 2.01 4.2 ± 0.65 afterimage 1 to 15 4.5 ± 1.71 2.5 ± 0.99 Glare 1 to 15 6.1 ± 1.24 3.5 ± 0.76 Snow forest 1 to 15 9.9 ± 1.23 4.3 ± 1.49 congestion 1 to 15 11.8 ± 1.75 4.2 ± 1.79 film 1 to 15 10 ± 1.55 4.5 ± 0.71 Foreign body feeling 1 to 15 7.8 ± 1.25 4.8 ± 0.75 Nip 1 to 15 8.2 ± 2.1 4 ± 0.21 Tiredness in the afternoon 1 to 15 12.9 ± 1.66 5.1 ± 0.73 Burning sensation 1 to 15 8.9 ± 2.11 4.3 ± 1.25 Focusing time 1 to 15 9 ± 1.25 5.5 ± 0.78

As shown in Table 4 and FIG. 2, the subjects were evaluated that the health condition of the eyes including the fatigue of the eyes after the ingestion of the fruit extract of the ginseng was improved by 50% or more and the extract of the ginseng fruit It was found to be effective.

In addition, in addition to the results of Test Example 2, the subjects were able to feel an improvement in overall body fatigue and mental stability as well as eyes after intake of ginseng fruit extract, improved skin condition, As well. Therefore, it was found that the extract of Ginseng fruit is very effective for promoting the health of the human body including eyes.

Formulation examples of compositions according to one embodiment of the present invention are described below, but may be applied to various other formulations, which are not intended to be limiting but merely illustrative of the invention.

[Formulation Example 1] 100% extract of ginseng fruit

The ginseng fruit extract of Example 1 was concentrated to a solid content of at least 60%, and after aging at a low temperature, a liquid form of 100% extract was prepared.

[Formulation Example 2] Soft capsule

A soft capsule was prepared by mixing 110 mg of the ginseng fruit extract of Example 1, 0.8 mg of palm oil, 0.48 mg of vegetable hardened oil, 2.4 mg of yellowing powder and 3.6 mg of lecithin and filling them according to a conventional method.

[Formulation Example 3] Tablets

160 mg of the ginseng fruit extract of Example 1, 200 mg of glucose, and 196 mg of dextrin were mixed and granulated using a fluidized bed drier, and then 7 mg of sugar ester was added thereto and tableted by tabletting.

[Formulation Example 4] Production of pills

0.9 g of the ginseng fruit extract of Example 1, 0.3 g of sugar, 1.91 g of starch and 0.56 g of glycerin were mixed and a ring was prepared using a ventilator.

[Preparation Example 5]

160 mg of the ginseng fruit extract of Example 1, 200 mg of glucose and 196 mg of dextrin were mixed, granulated using a fluidized bed drier, and filled in a bag to prepare a granule.

[Production Example 6]

110 mg of the ginseng fruit extract of Example 1, 10 g of glucose, and 2 g of citric acid were mixed and then 188 g of purified water was added to fill each bottle with 200 ml each. The beverage was filled in bottles and sterilized at 90 ° C for 2-3 hours.

Claims (7)

A composition for enhancing eye health comprising an extract of ginseng fruit as an active ingredient. The composition for enhancing eye health according to claim 1, wherein the ginseng fruit extract contains anthocyanin. The anthocyanin according to claim 2, wherein the anthocyanin is at least one selected from the group consisting of Malvidin Chloride, Ideain chloride, Pelagonidin chloride and Keracyanin chloride Or a pharmaceutically acceptable salt thereof. The composition for enhancing eye health according to claim 1, wherein the ginseng fruit extract contains more Protopanaxatriol (PT) system than ginsenoside PD (Protopanaxadiol) system. The composition for improving eye health according to claim 1, wherein the composition improves eye fatigue. The composition for improving eye health according to claim 1, wherein the composition is a pharmaceutical composition or a food composition. The method according to claim 1, wherein the ginseng fruit extract
(a) pretreating the fruit of ginseng; and
(b) extracting the ginseng fruit pretreated in the above step with water or an organic solvent to obtain a ginseng fruit extract.

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