KR20140011311A - Pi3k 억제제 및 mek 억제제를 포함하는 조성물 및 암을 치료하기 위한 이의 용도 - Google Patents

Pi3k 억제제 및 mek 억제제를 포함하는 조성물 및 암을 치료하기 위한 이의 용도 Download PDF

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KR20140011311A
KR20140011311A KR1020137017879A KR20137017879A KR20140011311A KR 20140011311 A KR20140011311 A KR 20140011311A KR 1020137017879 A KR1020137017879 A KR 1020137017879A KR 20137017879 A KR20137017879 A KR 20137017879A KR 20140011311 A KR20140011311 A KR 20140011311A
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compound
cancer
tumor
formula
combination
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로랑 드뷔슈
카를로스 가르시아-에쉐베리아
?궈 마
스튜어트 맥밀란
자넷 앤 모이러 오그던
루아 벵상
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사노피
메르크 파텐트 게엠베하
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
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    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
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    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020137017879A 2010-12-09 2011-12-08 Pi3k 억제제 및 mek 억제제를 포함하는 조성물 및 암을 치료하기 위한 이의 용도 Withdrawn KR20140011311A (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US42146510P 2010-12-09 2010-12-09
US61/421,465 2010-12-09
US201161436258P 2011-01-26 2011-01-26
US61/436,258 2011-01-26
US201161467485P 2011-03-25 2011-03-25
US61/467,485 2011-03-25
FR1159940 2011-11-03
FR1159940 2011-11-03
PCT/US2011/063871 WO2012078832A1 (en) 2010-12-09 2011-12-08 Compositions comprising a pi3k inhibitor and a mek inhibitor and their use for treating cancer

Publications (1)

Publication Number Publication Date
KR20140011311A true KR20140011311A (ko) 2014-01-28

Family

ID=45464841

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137017879A Withdrawn KR20140011311A (ko) 2010-12-09 2011-12-08 Pi3k 억제제 및 mek 억제제를 포함하는 조성물 및 암을 치료하기 위한 이의 용도

Country Status (23)

Country Link
US (1) US20140024653A1 (enExample)
EP (1) EP2648729A1 (enExample)
JP (1) JP2013544892A (enExample)
KR (1) KR20140011311A (enExample)
CN (1) CN103402518A (enExample)
AR (1) AR084216A1 (enExample)
AU (1) AU2011338354A1 (enExample)
BR (1) BR112013014198A2 (enExample)
CA (1) CA2820748A1 (enExample)
CL (1) CL2013001643A1 (enExample)
CR (1) CR20130246A (enExample)
DO (1) DOP2013000131A (enExample)
MA (1) MA34815B1 (enExample)
MX (1) MX2013006319A (enExample)
NZ (1) NZ611581A (enExample)
PE (1) PE20140702A1 (enExample)
PH (1) PH12013501163A1 (enExample)
RU (1) RU2013131241A (enExample)
SG (1) SG190368A1 (enExample)
TW (1) TW201306837A (enExample)
UY (1) UY33790A (enExample)
WO (1) WO2012078832A1 (enExample)
ZA (1) ZA201303687B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20142020A1 (es) * 2012-04-06 2014-12-24 Sanofi Sa Metodos para tratar el cancer usando inhibidor de pi3k e inhibidor de mek
WO2014056566A1 (en) * 2012-10-11 2014-04-17 Merck Patent Gmbh Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a mek inhibitor
ES2779975T3 (es) 2014-02-07 2020-08-21 Verastem Inc Métodos y composiciones para tratar el crecimiento celular anormal
WO2016014390A1 (en) * 2014-07-25 2016-01-28 Merck Patent Gmbh Compositions and methods for mek inhibitor combination therapy in the treatment of cancer
CN111433604B (zh) * 2017-12-22 2023-12-08 瑞士商艾迪安纳股份有限公司 用于确定抗cd26配体的生物活性的定量细胞方法
JP2022547358A (ja) 2019-09-13 2022-11-14 ジ インスティテュート オブ キャンサー リサーチ:ロイヤル キャンサー ホスピタル 治療組成物、組み合わせ、及び使用方法
BR112023006954A2 (pt) * 2020-10-16 2024-01-16 Memorial Sloan Kettering Cancer Center Indução de ferroptose para terapia de câncer
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor

Also Published As

Publication number Publication date
PE20140702A1 (es) 2014-06-26
CN103402518A (zh) 2013-11-20
JP2013544892A (ja) 2013-12-19
EP2648729A1 (en) 2013-10-16
DOP2013000131A (es) 2013-11-15
BR112013014198A2 (pt) 2016-09-13
US20140024653A1 (en) 2014-01-23
PH12013501163A1 (en) 2013-07-29
CR20130246A (es) 2013-09-03
UY33790A (es) 2012-07-31
CA2820748A1 (en) 2012-06-14
WO2012078832A1 (en) 2012-06-14
RU2013131241A (ru) 2015-01-20
MA34815B1 (fr) 2014-01-02
ZA201303687B (en) 2014-01-29
NZ611581A (en) 2015-02-27
SG190368A1 (en) 2013-06-28
MX2013006319A (es) 2013-07-03
AU2011338354A1 (en) 2013-06-27
CL2013001643A1 (es) 2014-03-28
TW201306837A (zh) 2013-02-16
AR084216A1 (es) 2013-05-02

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Patent event date: 20130708

Patent event code: PA01051R01D

Comment text: International Patent Application

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WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid