KR20130142137A - 모노아실글리세롤 리파아제 억제제로서의 피페리딘-4-일-아제티딘 다이아미드 - Google Patents
모노아실글리세롤 리파아제 억제제로서의 피페리딘-4-일-아제티딘 다이아미드 Download PDFInfo
- Publication number
- KR20130142137A KR20130142137A KR1020137012911A KR20137012911A KR20130142137A KR 20130142137 A KR20130142137 A KR 20130142137A KR 1020137012911 A KR1020137012911 A KR 1020137012911A KR 20137012911 A KR20137012911 A KR 20137012911A KR 20130142137 A KR20130142137 A KR 20130142137A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- thiazol
- group
- trifluoromethyl
- unsubstituted
- Prior art date
Links
- BOCVQFNQLOJDLV-UHFFFAOYSA-N CCCNC(c1ncc[s]1)=O Chemical compound CCCNC(c1ncc[s]1)=O BOCVQFNQLOJDLV-UHFFFAOYSA-N 0.000 description 2
- 0 C*(C)c1cccc(C(F)(F)F)c1 Chemical compound C*(C)c1cccc(C(F)(F)F)c1 0.000 description 1
- PJKWQSLEIWSWPK-LHHJGKSTSA-N CC(C)C/C(/Nc(cc1)ccc1F)=C\C=C Chemical compound CC(C)C/C(/Nc(cc1)ccc1F)=C\C=C PJKWQSLEIWSWPK-LHHJGKSTSA-N 0.000 description 1
- QOVJYSPFWNEOTD-UHFFFAOYSA-N COC(CC1)(CCN1C(c1ccccc1)=O)C(C1)CN1C(c1cc(cc(C(F)(F)F)cc2)c2[s]1)=O Chemical compound COC(CC1)(CCN1C(c1ccccc1)=O)C(C1)CN1C(c1cc(cc(C(F)(F)F)cc2)c2[s]1)=O QOVJYSPFWNEOTD-UHFFFAOYSA-N 0.000 description 1
- ZCHJKNUFQIPLCL-UHFFFAOYSA-N COC(c(cc1)cc(cc2)c1[n]2-c(cc1)ccc1F)=O Chemical compound COC(c(cc1)cc(cc2)c1[n]2-c(cc1)ccc1F)=O ZCHJKNUFQIPLCL-UHFFFAOYSA-N 0.000 description 1
- DRYBMFJLYYEOBZ-UHFFFAOYSA-N COC(c(cc1)cc2c1[nH]cc2)=O Chemical compound COC(c(cc1)cc2c1[nH]cc2)=O DRYBMFJLYYEOBZ-UHFFFAOYSA-N 0.000 description 1
- AITNMTXHTIIIBB-UHFFFAOYSA-N Fc(cc1)ccc1Br Chemical compound Fc(cc1)ccc1Br AITNMTXHTIIIBB-UHFFFAOYSA-N 0.000 description 1
- IBCVAYQWXMWFLD-UHFFFAOYSA-N IC(C1)CN1C(c1ccccc1)c1ccccc1 Chemical compound IC(C1)CN1C(c1ccccc1)c1ccccc1 IBCVAYQWXMWFLD-UHFFFAOYSA-N 0.000 description 1
- NZAXGZYPZGEVBD-UHFFFAOYSA-N O=C(c1ccccc1)N(CC1)CCC1=O Chemical compound O=C(c1ccccc1)N(CC1)CCC1=O NZAXGZYPZGEVBD-UHFFFAOYSA-N 0.000 description 1
- NGPMQRXGAGKLNA-UHFFFAOYSA-N O=C(c1ncc[s]1)N(CC1)CCC1C(C1)CN1C(c(cc1)ccc1-c1cccc(C(F)(F)F)c1)=O Chemical compound O=C(c1ncc[s]1)N(CC1)CCC1C(C1)CN1C(c(cc1)ccc1-c1cccc(C(F)(F)F)c1)=O NGPMQRXGAGKLNA-UHFFFAOYSA-N 0.000 description 1
- PPDMNMAECIVDQS-UHFFFAOYSA-N O=C(c1ncc[s]1)N(CC1)CCC1C1CNC1 Chemical compound O=C(c1ncc[s]1)N(CC1)CCC1C1CNC1 PPDMNMAECIVDQS-UHFFFAOYSA-N 0.000 description 1
- OOFNWBRCNZBLOJ-UHFFFAOYSA-N OC(CC1)(CCN1C(c1ccccc1)=O)C(C1)CN1C(c1ccccc1)c1ccccc1 Chemical compound OC(CC1)(CCN1C(c1ccccc1)=O)C(C1)CN1C(c1ccccc1)c1ccccc1 OOFNWBRCNZBLOJ-UHFFFAOYSA-N 0.000 description 1
- CYVZLFMJYDLKEM-UHFFFAOYSA-N OC(CC1)(CCN1C(c1ccccc1)=O)C1CNC1 Chemical compound OC(CC1)(CCN1C(c1ccccc1)=O)C1CNC1 CYVZLFMJYDLKEM-UHFFFAOYSA-N 0.000 description 1
- OHQPVSORYCUZRN-UHFFFAOYSA-N OC(c(cc1)cc(cc2)c1[n]2-c(cc1)ccc1F)=O Chemical compound OC(c(cc1)cc(cc2)c1[n]2-c(cc1)ccc1F)=O OHQPVSORYCUZRN-UHFFFAOYSA-N 0.000 description 1
- LFMPHDUPXVEMAB-UHFFFAOYSA-N OC(c(cc1)ccc1-c1cccc(C(F)(F)F)c1)=O Chemical compound OC(c(cc1)ccc1-c1cccc(C(F)(F)F)c1)=O LFMPHDUPXVEMAB-UHFFFAOYSA-N 0.000 description 1
- ROIKYRUNAMGSHG-UHFFFAOYSA-N OC(c1cc2cc(C(F)(F)F)ccc2[s]1)=O Chemical compound OC(c1cc2cc(C(F)(F)F)ccc2[s]1)=O ROIKYRUNAMGSHG-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40587610P | 2010-10-22 | 2010-10-22 | |
| US61/405,876 | 2010-10-22 | ||
| PCT/US2011/057085 WO2012054716A1 (en) | 2010-10-22 | 2011-10-20 | Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130142137A true KR20130142137A (ko) | 2013-12-27 |
Family
ID=44993878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137012911A KR20130142137A (ko) | 2010-10-22 | 2011-10-20 | 모노아실글리세롤 리파아제 억제제로서의 피페리딘-4-일-아제티딘 다이아미드 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2629851A1 (pt) |
| JP (1) | JP2013540159A (pt) |
| KR (1) | KR20130142137A (pt) |
| CN (1) | CN103260703A (pt) |
| AR (1) | AR083542A1 (pt) |
| AU (1) | AU2011316970A1 (pt) |
| BR (1) | BR112013009858A2 (pt) |
| CA (1) | CA2815350A1 (pt) |
| IL (1) | IL225769A0 (pt) |
| RU (1) | RU2013123275A (pt) |
| TW (1) | TW201305136A (pt) |
| WO (1) | WO2012054716A1 (pt) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180129849A (ko) * | 2016-03-31 | 2018-12-05 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014239542A1 (en) * | 2013-03-15 | 2015-10-01 | Araxes Pharma Llc | Covalent inhibitors of KRas G12C |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| US9745319B2 (en) | 2013-03-15 | 2017-08-29 | Araxes Pharma Llc | Irreversible covalent inhibitors of the GTPase K-Ras G12C |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| EP3087067B1 (en) | 2013-12-26 | 2018-10-24 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (magl) inhibitors |
| JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
| WO2016049524A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| US10106556B2 (en) | 2015-03-30 | 2018-10-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN107849022A (zh) | 2015-04-10 | 2018-03-27 | 亚瑞克西斯制药公司 | 取代的喹唑啉化合物和其使用方法 |
| WO2016168540A1 (en) | 2015-04-15 | 2016-10-20 | Araxes Pharma Llc | Fused-tricyclic inhibitors of kras and methods of use thereof |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10875842B2 (en) | 2015-09-28 | 2020-12-29 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| WO2017058768A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3356339A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| WO2017070256A2 (en) | 2015-10-19 | 2017-04-27 | Araxes Pharma Llc | Method for screening inhibitors of ras |
| AU2016355433C1 (en) | 2015-11-16 | 2021-12-16 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
| WO2017100546A1 (en) | 2015-12-09 | 2017-06-15 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| US10463753B2 (en) | 2016-02-19 | 2019-11-05 | Lundbeck La Jolla Research Center, Inc. | Radiolabeled monoacylglycerol lipase occupancy probe |
| US10822312B2 (en) | 2016-03-30 | 2020-11-03 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
| JP6832342B2 (ja) | 2016-03-31 | 2021-02-24 | 武田薬品工業株式会社 | 複素環化合物 |
| US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
| US10280172B2 (en) | 2016-09-29 | 2019-05-07 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10377743B2 (en) | 2016-10-07 | 2019-08-13 | Araxes Pharma Llc | Inhibitors of RAS and methods of use thereof |
| EP3573971A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| EP3573967A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused hetero-hetero bicyclic compounds and methods of use thereof |
| EP3573970A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| US10736897B2 (en) | 2017-05-25 | 2020-08-11 | Araxes Pharma Llc | Compounds and methods of use thereof for treatment of cancer |
| BR112019024674A2 (pt) | 2017-05-25 | 2020-06-16 | Araxes Pharma Llc | Inibidores covalentes da kras |
| WO2018218069A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant kras, hras or nras |
| MX2020007318A (es) | 2017-09-29 | 2020-08-24 | Takeda Pharmaceuticals Co | Compuesto heterociclico. |
| MA53722A (fr) | 2018-09-28 | 2022-03-30 | Janssen Pharmaceutica Nv | Modulateurs de la monoacylglycérol lipase |
| CN109879797A (zh) * | 2019-01-10 | 2019-06-14 | 安徽昊帆生物有限公司 | N-苄基-四氢吡啶类化合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9812037D0 (en) * | 1998-06-04 | 1998-07-29 | Pfizer Ltd | Piperidones |
| US8106208B2 (en) * | 2006-05-18 | 2012-01-31 | Albireo Ab | Benzamide compounds that act as NK receptor antagonists |
| FR2915198B1 (fr) * | 2007-04-18 | 2009-12-18 | Sanofi Aventis | Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique. |
| JP5715945B2 (ja) * | 2008-04-25 | 2015-05-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | モノアシルグリセロールリパーゼ（ｍｇｌｌ）の結晶構造 |
| AU2010234087B2 (en) * | 2009-04-02 | 2016-05-12 | Merck Patent Gmbh | Piperidine and piperazine derivatives as autotaxin inhibitors |
| WO2010124082A1 (en) * | 2009-04-22 | 2010-10-28 | Janssen Pharmaceutica Nv | Azetidinyl diamides as monoacylglycerol lipase inhibitors |
-
2011
- 2011-10-20 BR BR112013009858A patent/BR112013009858A2/pt not_active IP Right Cessation
- 2011-10-20 CA CA2815350A patent/CA2815350A1/en not_active Abandoned
- 2011-10-20 JP JP2013535086A patent/JP2013540159A/ja active Pending
- 2011-10-20 AU AU2011316970A patent/AU2011316970A1/en not_active Abandoned
- 2011-10-20 WO PCT/US2011/057085 patent/WO2012054716A1/en active Application Filing
- 2011-10-20 CN CN201180061809XA patent/CN103260703A/zh active Pending
- 2011-10-20 RU RU2013123275/04A patent/RU2013123275A/ru not_active Application Discontinuation
- 2011-10-20 KR KR1020137012911A patent/KR20130142137A/ko not_active Application Discontinuation
- 2011-10-20 EP EP11784828.3A patent/EP2629851A1/en not_active Withdrawn
- 2011-10-21 TW TW100138198A patent/TW201305136A/zh unknown
- 2011-10-24 AR ARP110103927A patent/AR083542A1/es not_active Application Discontinuation
-
2013
- 2013-04-15 IL IL225769A patent/IL225769A0/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180129849A (ko) * | 2016-03-31 | 2018-12-05 | 다케다 야쿠힌 고교 가부시키가이샤 | 헤테로시클릭 화합물 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201305136A (zh) | 2013-02-01 |
| AR083542A1 (es) | 2013-03-06 |
| EP2629851A1 (en) | 2013-08-28 |
| IL225769A0 (en) | 2013-06-27 |
| JP2013540159A (ja) | 2013-10-31 |
| CN103260703A (zh) | 2013-08-21 |
| AU2011316970A1 (en) | 2013-05-09 |
| CA2815350A1 (en) | 2012-04-26 |
| RU2013123275A (ru) | 2014-11-27 |
| BR112013009858A2 (pt) | 2016-07-26 |
| WO2012054716A1 (en) | 2012-04-26 |
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