KR20130103039A - Composition for preventing or treating blood vessel-related disease - Google Patents

Abstract

PURPOSE: A pharmacological composition for preventing vascular diseases is provided to prevent and treat vascular diseases such as angina, brain disease, stroke, and hypertension by dissolving wastes of blood vessel and to have anticancer effect. CONSTITUTION: A pharmacological composition for preventing vascular diseases contains 6-8 wt% of Euonymus alatus, 4-6 wt% of Viscum album var. coloratum, 4-6 wt% of Adenophora triphylla var. japonica (Regel) H. Hara, 5-7 wt% of Ulmus davidiana, 5-7 wt% of ginger, 4-6 wt% of Broussonetia kazinoki S., 4-6 wt% of Allium fistulosum roots, 10-12 wt% of kudzu roots, 5-7 wt% of Hovenia dulcis, 10-12 wt% of Schizandra chinensis BAALL., 3-4 wt% of Aconiti iateralis preparata Radix, and remaining amount of onion. The pharmacological composition contains a hot water extract as an active ingredient. The pharmacological composition contains a powder extract as an active ingredient, which is prepared by freeze-drying the hot water extract.

Description

Pharmacological composition for prevention of vascular disease {COMPOSITION FOR PREVENTING OR TREATING BLOOD VESSEL-RELATED DISEASE}

The present invention relates to a pharmacological composition for preventing vascular diseases, and more particularly to a pharmacological composition for preventing vascular diseases that can prevent or treat vascular diseases by dissolving waste products in blood vessels.

As is well known, in most of the countries except for the underdeveloped countries, overproduction is more problematic than the lack of agricultural products, so humanity has been liberated from poverty and entered into the era of life extension due to the development of medical and biotechnology. However, as westernization and modernization of society progresses, diseases such as cardiovascular diseases, cancer, hypertension, diabetes and obesity are increasing due to lack of exercise, increase of stress, overeating, increase of intake of animal food, It's getting bigger and bigger.

In particular, according to the statistics of the 1900s, cardiovascular disease was the fourth most common cause of pneumonia, influenza, tuberculosis, diarrhea and enteritis, accounting for only 8% of the total deaths. Cardiovascular diseases such as cerebrovascular disease, angina pectoris caused by arteriosclerosis, paralysis caused by atherosclerosis, coronary artery disease such as angina pectoris, myocardial infarction, heart disease and heart attack constitute the leading cause of adult death worldwide. Vascular diseases account for 37% of all deaths.

In the case of cardiovascular disease, which is a representative adult disease, the main cause of hypercholesterolemia due to an increase in animal food consumption is the fact that hypercholesterolemia and hyperlipemia cause cardiovascular diseases and also cause other diseases such as diabetes, hypertension, obesity and dementia That's serious.

With the modernization of society, the importance of prevention of cardiovascular diseases and other adult diseases is getting more and more important. The primary way to do this is balanced nutrition through balanced intake of food. In addition to the energy and nutrient sources needed for daily life, various foods contain essential ingredients that prevent disease and promote health. It is well known that even food intake is sufficient to prevent adult diseases. For example, vitamins of orange, resveratol of grape, allicin of garlic or onion, lycopene of tomato, lycopene of tomato, Isoflavone of soybean, flavonoid of Chinese cabbage, and tannin of persimmon are the food components whose physiologically active ingredient and function are known. However, there is a limit to the amount of preventive ingredients for adult diseases that are ingested through food, which makes it difficult to obtain an adequate amount of food for a long period of time in a balanced manner.

Secondary methods for the prevention of cardiovascular diseases and other adult diseases include various health supplements made by extracting specific components of physiologically active substances present in small amounts in medicinal plants. However, existing adult health supplement foods contain only a certain amount of physiologically active substance in a single component, and thus an adult having already undergoing aging has disadvantages in that it may impair nutritional imbalance and liver function during long-term administration have. In addition, it is important to maintain and strengthen comprehensive physical functions because the onset of any one of the four adult diseases causes an adult disease, which is rapidly progressing aging. In other words, the body defense mechanism such as immune function weakens and the aging of the body is rapidly proceeding. Due to the abnormality of specific physiological function, the onset of one adult disease immediately leads to imbalance of body metabolism, Often resulting in death.

Therefore, in order to prevent adult diseases, it is necessary to simultaneously supply various active ingredients having an effect of supplementing the homeostasis in the body of the aging adult. However, it is better to choose one or two medicinal plants that have complex physiologically active substances, rather than overeating a variety of health supplements that contain only a certain physiologically active substance in a single component. In other words, it is the main point of adult health to maintain comprehensive body function by supplying various active substances that regulate various metabolic control functions of the body through one or two medicinal plant groups.

In particular, vascular diseases, which are the main cause of adult diseases and cancer, need to be managed extensively together with food and exercise, including lifestyle, but there is still a problem that efficient management of vascular diseases is insufficient.

SUMMARY OF THE INVENTION The present invention has been made in view of the circumstances of the prior art described above, and it is an object of the present invention to provide a vascular disease which can dissolve vascular waste and prevent vascular diseases such as conspicuity, brain disease, stroke, and hypertension, The present invention also provides a pharmaceutical composition for prevention of cancer.

In order to achieve the above object, according to a preferred embodiment of the present invention, 6-8% by weight of oak tree, 4-6% by weight of mistletoe, 4-6% by weight, 5-7% by weight of root skin, 5 to 7% by weight ginger, 4 to 6% by weight of mulberry, 5 to 7% by weight of green onion root, 10 to 12% by weight of brown root, 5 to 7% by weight of liana, 10 to 12% by weight of Schisandra chinensis, 3 to 4% by weight of rich And it provides a pharmacological composition for preventing vascular disease, characterized in that the remaining amount to include onion.

The pharmacological composition for preventing vascular diseases according to the present invention is capable of preventing and treating various vascular-related diseases such as conspicuity, brain disease, stroke, and hypertension by removing vascular waste, and has the advantage of being clinically effective against various cancers.

Hereinafter, the present invention will be described in detail.

A pharmacological composition for preventing vascular diseases according to an embodiment of the present invention is a pharmaceutical composition for preventing vascular diseases such as syngeneism, brain disease, stroke, and hypertension by dissolving vascular waste, Is a pharmacological composition for preventing diseases.

Hereinafter, components constituting the pharmaceutical composition for preventing vascular diseases according to an embodiment of the present invention will be described.

Natural wood (arrow tree) is good for all kinds of adult diseases, has excellent anticancer effect and is a native herb tree in Korea. It is known that the true tree has a special effect on diabetes, atherosclerosis and blood circulation.

Mistletoe (Viscum album L., Loranthaceae) is an antiparasitic plant that grows on various trees such as oak, pine and cherry trees. It is used as a remedy for hypertension, arteriosclerosis and malignant tumors through folk medicine in various parts of Europe . It has been reported to increase the survival rate of cancer patients in clinical trials for animals and humans, and some European hospitals and some hospitals in Korea have been using the extract of European mistletoe for clinical purposes for the purpose of cancer treatment.

Actinic substances that play a role in demonstrating such cytotoxic and immunomodulatory effects in mistletoe extracts include lectins and polypeptides such as viscotoxin and saccharides polysaccharides and oligosaccharides, Alkaloids, etc. Among them, lectin has been recognized as a main component of anticancer and immunoenhancing activity, and most intensive studies have been conducted. Studies on Korean mistletoe have also been actively conducted recently. Antitumor and immune-enhancing activity of the lectin component of Korean mistletoe have been reported, and the lectin component (KML-C) having specificity as a main active substance has been isolated.

Zande is effective in eliminating all kinds of poison such as snake poison, pesticide poison, heavy metal poison, chemical poison, etc. and is also effective in preventing diseases caused by various poisons.

ULMUS DAVIDIANA, the skin of the elm roots, is said to have the function of softening the skin when it is soaked in water. The efficacy of yuukeepi in Donguibogam is balanced, tasteful, and poisonous, and it is said to smooth the feces, to eliminate the quadriplegic effect, to be effective in enteritis, to calm the swollen and to relieve insomnia. He also said he listens to various gastrointestinal diseases such as gastric ulcer, gastritis, gastric ulcer, and gastric ulcer. Conventional studies on yugaepi have been conducted on immunosuppressants (Korean Patent Registration No. 1002475670000) and edible beverages, and are known to be studied as antitumor and anti-inflammatory compositions and have efficacy.

Regarding pharmacological effects of ginger, ginger extract has been reported to inhibit DNA damage, tumor suppression and inflammation, cold, headache, mental fatigue, etc., and lipid lowering effect, antioxidant activity and antibacterial activity Are reported.

According to the Oriental Medicine, ginger, especially when steamed steaming or boiling, and when taking it as dry health, it is said that it is used for removing the cold of the five pieces of meat, through the planting as an extinguishing agent and as an extinguishing agent. The ginger is stimulated by the secretion of digestive juice And the ingredients that promote the movement of the stomach to improve appetite, digestion and absorption is known to help. This is because ginger contains diastase and proteolytic enzymes to help digestion of sashimi, and the flavor component of ginger helps digestion and absorption of digestive organs. It is also known that ginger removes the fence, stops the vomiting, removes the wind and swelling, and controls asthma. The direction of the ginger is known to increase blood circulation and body temperature. Thus, the use of ginger appears to be very frequent in Oriental medicine.

On the other hand, the spicy component of ginger is mainly composed of compounds belonging to a compound known as vanillic ketones such as schogol, gingerol and gingerol. These ingredients can be regarded as derivatives of guaiacol, which are combined with various essential oil components to show bactericidal activity against bacteria such as typhus and cholera. Especially, gingerol and shogaol have a strong sterilizing effect against various pathogenic bacteria It is known. In addition, it has been found that the effect of ginger is higher than that of garlic or onion in inhibiting blood clotting, especially when the amount of ginger is low.

Mulberry (Broussonetia Kazinoki S.) is a deciduous broad-leaved shrub belonging to the genus Chrysanthemum bisporus. It grows well in the warm and rainy regions and grows well in the Yangji.

The mulberry bark has been mainly used as a raw material of Korean paper, and it has various medicinal effects. It has effects on the skin, pineal gland, skin tone, species, wings, diuretic, etc. It removes wind, clears blood, And is known to have efficacy.

Onion is a perennial plant belonging to the lily family, which is used as a spice for a variety of dishes, both east and west. In the private sector, onions are stamina foods that enhance the energetic and metabolism, help digestive enzymes in the intestines, protect the capillaries to improve blood circulation, prevent diabetes, prevent blood pressure and arteriosclerosis, Has been widely used as.

Quercetin, quercitrin, rutin, etc., which are flavonoid-based components, are included in the physiologically active ingredient contained in the onion. Allyl propyl disulfide, And diallyl disulfide. It also contains antioxidant activity, reduced activity of carcinogens, enzymatic inhibition of cancer cells, antibacterial activity, detoxification of heavy metals, mitigation of carbon tetrachloride toxicity, and inhibition of lipid peroxidation Reported. Of the more than 4,000 flavonoid substances reported so far, quercetin has been recognized as a representative flavonoid in terms of the amount contained or the amount ingested in plant foods.

The roots are called white roots and white roots. It is used for cold, indigestion, diarrhea, skin ulcer, swelling and early pregnancy anxiety. It improves blood circulation and improves cold constitution, and is effective for pain and shoulder stiffness caused by neuralgia.

Pueraria lobata Ohwi, a perennial herbaceous plant of soybean plants, is a herb that is naturally grown in the mountains of Korea, China and Japan. In Oriental medicine, various parts of 칡 are classified respectively, and dry root is called as purple root, flower is golden root, fruit is golden root or goat, leaves are bifurcated, and vine is called goldenrum.

It is used for the purpose of breaking down cold body, digestive diseases, and intestinal tract. It helps to raise the spleen and stomach, so it makes cold and relieve thirst and acts as a branch. (Herbology, 148, 1995). In Sasang medicine, it is classified as a drug of Taeumin, and it is used for the basic prescription such as Kanggeunhaegeok, Deokdahanbang, Ganggukseongtang, Piecesangwangtang,

Purkinje contains a large amount of isoflavonoide (Clinical Application of Modern Chinese Medicine, 626, 1994), and many studies on isoflavonoid-related components have been reported. The pharmacological actions associated with Puerariae include antidipsotropic action (Proceeding of National Academy of Sciences, 95 (5): 2198-203, 1998; Alcoholism: Clinical & Experimental Research 40 (4): 659-63, 1996), hepatoprotective action (Planta Medica, 64 (5): 413-6, 1998), antioxidant activity (Proceedings of the National Academy of Sciences, USA 94 (5): 1675-9, 1997) Chem. Pharm. Bull. 40 (3): 721-4, 1992). In addition, smooth muscle relaxation, coronary artery dilatation and hypotension in cardiovascular, heart rate control, platelet aggregation inhibition, hyperglycemia, and antipyretic action are known (Clinical Application of Clinical Contemporary Research, 626-632, 1994) , Headache of elderly illnesses, gastrointestinal disturbances, limb-numbness, diarrhea, and diabetes (Pharmacology, 186-187, 1989). However, there has been no report on the use of granulocyte or crab directly for the relief of symptoms such as obesity or hyperlipidemia.

Licorice is a widely known ingredient and has a sweetness. It also has excellent neutralizing and detoxifying effect against poison, has effect on antiallergic action, gastric ulcer, duodenal ulcer, prevention of arteriosclerosis, enhancement of liver function, pleurisy and pulmonary tuberculosis It has a therapeutic effect and has a remarkable effect on various diseases such as anterior pituitary dysfunction, Edison's disease, epidemic hepatitis, bronchial asthma, dermatitis (urticaria, eczema, acne, freckle), schizophrenia, And is being used as an additive in many foods.

Honenia dulcis is a deciduous broad-leaved arboreous tree, and is also known as the earth tree. It is distributed in Korea (mainly in Gangwon and southern Yellow Sea), Japan, China, etc. The tree grows up to 10 ~ 17m in height , The bark is black gray, and the small branch is brown-purple and has a skin. The winter snow is covered with two eye scales and has hair. Leaves are 8 ~ 15cm long, ovate, wide oval or oval. There are three coarse veins on the leaf, with serrate on the edge, and white flowers bloom mainly in June to July. The flowers run in turn. There are five sepals and petals, and the style divides into three. The fruit is brown with a diameter of 8 mm and is shaped like a chicken's claw. Three seeds of fruit contain one seed each. Seeds are dark brown and glossy.

In addition, when the fruit is ripened, the honggye (果 莖) becomes thick and rugged. It has a soft scent, it has a sweet taste, and it tastes like a food. In the pharmacopeia, the hornblende has a function of drinking alcohol, and the juice is said to release nausea and stop nausea. Wood is used as building materials, furniture materials, musical instruments and so on.

Hovenia trees are tranquil and non-toxic in the herbaceous gardens, are soft and lubricious, and have a good view of the stools and urine, eliminating the heat on the chest, releasing thirst, relieving digestion, It is supposed to eliminate five kinds of hemorrhoids.

Schizandra chinensis (Schizandra chinensis) is a deciduous plant of the genus Schizandra, and its fruit is mostly circular, ripened in August to September as a scarlet color, containing 1 to 2 seeds, strong in sour taste and containing medicinal ingredients, It contains ingredients such as Schizandrin, Gomisin, Citral, Malic acid and Citric acid to strengthen the heart, reduce blood pressure, increase immunity, and use it as a tonic. It is known that it has the effect of strengthening the pulmonary function, treating the cough and thirst by the action of the deep sea bream and the god dam.

Abundant Radix Aconiti Lateralis Preparata contains aconitine (C23H4NO11) and varies in amount and quality depending on the size and origin of the root. Kidney swells and has a cardiovascular effect due to various chronic diseases, weakness, systemic and limb joint paralysis, cold feeling, chronic ulcers, erosion, diarrhea, etc. are used. Pharmacological actions include cardiac muscle contraction, blood pressure rise, anti-inflammatory, analgesic, anti-cold action, immunopotentiation, pituitary and adrenal cortex excitability, and hypoglycemic action.

Pharmacological composition according to the present invention is characterized in that comprises 13 or more.

All of these ingredients are meant to be in the form of conventional dry pharmaceutical formulations used in the manufacture of herbal medicines. When each of the above components is out of the range of the upper and lower limits, the effect of eliminating the hangover is weak or no.

The pharmacological composition of the present invention having the above composition can be subjected to hot water extraction by a conventional method to obtain a hot water extract. The extract can be lyophilized to obtain a dry extract per powder.

These extracts can be included as active ingredients to prevent and treat vascular diseases and to improve various symptoms of diseases.

The hot water extraction is preferably carried out at a temperature of 100-125 DEG C for 3-4 hours.

In addition, the pharmaceutical composition of the present invention having the above composition can be extracted by using an aqueous solution as a main solvent according to a conventional method, and an extract can be obtained. The extract or the dry powdery extract obtained by lyophilizing the extract can be used for prevention and treatment of vascular diseases .

The pharmacological composition of the present invention is not particularly limited as far as it is prepared so as to contain the above-mentioned ingredients, and may have a formulation such as, for example, a pill, a tablet, a capsule, a liquid preparation, a health food,

Hereinafter, the present invention will be described in detail with reference to Preparation Examples and Examples, but the present invention is not limited thereto.

≪ Preparation Example 1 >

1. Raw material powder process

6-8% by weight of oak tree, 4-6% by weight of mistletoe, 4-6% by weight of mule, 5-7% by weight of root bark, 5-7% by weight of ginger, 4-6% by weight of mulberry, leek root Onions were crushed into the mixer as 5 to 7% by weight, 10 to 12% by weight, 5 to 7% by weight of liana, 10 to 12% by weight of Schisandra chinensis, 3 to 4% by weight, and the balance.

≪ Preparation Example 2 &

400 g of the mixture of Preparation Example 1 was added to a flask containing 10 L of tertiary distilled water, and the mixture was subjected to hot water extraction at a temperature of 100 to 125 DEG C for 3 hours and packed in a pack of 120 cc using a packing machine.

≪ Test Example 1 >

Prevention of arteriosclerosis

New Zealand white rabbits were fed a diet containing 1% by weight of the pharmacological composition obtained in Preparation Example 1, in which only 1% by weight of cholesterol was added to a solid feed, and were fed for 6 weeks for 12 weeks. The rabbits were housed in cages with an automatic cleaning device. The feed was free, the drinking water was kept in bottled distilled water, the temperature was maintained at 20 ℃, the relative humidity was 55%, and the lighting was controlled at 12 hour intervals. Body weights were measured at intervals of one week, and blood was drawn at the beginning of the experiment and at the first week, and then at two-week intervals. After 12 weeks of feeding, they were fasted for 24 hours and anesthetized by injecting 50 mg of sodium pentobabital per body weight into the hypogastric vein. After blood was collected from the heart with a heparinized syringe, the liver was removed, washed with 0.9% physiological saline, immersed in liquid nitrogen and stored frozen at -70 ° C. Blood was collected at 3,000 rpm for 20 minutes, and plasma was obtained and stored frozen until analysis.

<Degree of aortic lipid deposition>

To measure the degree of lipid deposition in the aorta, we cut the arterial valve from the arterial valve of the rabbit to the junction of the ileum, rinsed the arterial blood with phosphate buffer, and extracted the fat from the arterial homogenate in the same manner And the results are shown in Table 1. &lt; tb &gt; &lt; TABLE &gt;

Fat (mg / g) cholesterol Triglyceride Total fat Control group 17.43 + - 0.42 ^b 1.24 0.08 ^c 70.10 + - 4.20 ^b Reagent composition Dietary supplement group 11.56 ± 0.32 ^c 1.62 ± 0.29 ^b 55.21 + - 1.10 ^d {Note} b and c subscripts mean that there is a significant difference in average within the same row (P <0.05)

As shown in Table 1, the cholesterol concentration of the aorta was found to be about 40% lower in the group fed with the pharmacological composition of the present invention than in the control group.

&Lt; Test Example 2 &

200 weekly aged rats (SAM P-8) were purchased from the Korea Research Institute of Chemical Technology and stabilized with Lab-chow diet for 4 weeks. Then, the animals were fed with the pharmacological composition of the present invention 50 rats per group were randomly divided into two groups and the diet prepared according to the composition of Table 2 was fed for one year.

SAM was stored at 20 ° C and relative humidity of 55%, and the light cycle was carried out at intervals of 12 hours. Respectively.

Dietary intake was recorded daily and body weight was measured weekly. Animals were fasted for 12 hours before sacrifice on the beginning and 1 year after the experiment, then anesthetized with dry ice in a desiccator, blood was collected from the heart with a heparinized syringe and centrifuged at 3,000 rpm for 20 minutes to isolate plasma Then, the cells were stored at -70 ° C until analysis, and then stored at -70 ° C.

<Neutral lipid, total cholesterol, HDL-cholesterol concentration measurement and arteriosclerosis index calculation

Total cholesterol Triglyceride HDL-C LDL-C Arteriosclerosis index 0 months 70.43 + - 7.59 62.43 + - 8.42 34.32 ± 1.22 51.27 + - 0.12 1.33 + - 0.42 12 months control 172.62 ± 28.75 ^a 131 ± 28.42 ^a 53.25 ± 19.23 ^b 98.45 ± 13.25 3.35 + 0.02 12 months Pharmacological composition group 108.07 ± 22.12 ^b 75.53 ± 14.25 ^ab 42.64 ± 13.88 ^ab 46.43 + - 4.92 1.32 ± 0.12 {Note} a and b subscripts mean that there is a significant difference in the mean within the same row (P <0.05)

As can be seen from Table 2, the plasma total cholesterol concentration was reduced by about 38% as compared with the control group not consuming kimchi according to the feeding of the pharmacological composition group, thereby significantly lowering the cholesterol concentration. The levels of HDL-cholesterol were not significantly different among the experimental groups, but LDL-cholesterol was decreased.

The concentration of plasma triglyceride was decreased by about 26%, and the effect was significant (p <0.05). The atherogenic index, atherogenic index, was also significantly lower than that of the control group, and the plasma lipid lowering effect was lower than that of the group not consuming the pharmacological composition.

Meanwhile, the pharmacological compositions for preventing vascular diseases according to the embodiments of the present invention are not limited to the above-described embodiments, but various modifications may be made without departing from the technical scope of the present invention.

Claims (3)

6-8% by weight of oak tree, 4-6% by weight of mistletoe, 4-6% by weight of mule, 5-7% by weight of root bark, 5-7% by weight of ginger, 4-6% by weight of mulberry, leek root 5 to 7% by weight, 10 to 12% by weight, 5 to 7% by weight of larvae, 10 to 12% by weight of Schisandra chinensis, 3 to 4% by weight, and the remaining amount of vascular disease, characterized in that it comprises an onion Pharmacological composition for. A pharmacological composition for preventing vascular disease, comprising a hot water extract prepared by hot water extract the composition of claim 1 as an active ingredient. Pharmacological composition for preventing vascular diseases comprising a powdered extract prepared by lyophilizing the hot water extract of claim 2 as an active ingredient.