KR20130102307A - Composition for improving heart and liver function and functional food comprising thererof - Google Patents

Abstract

PURPOSE: A composition for improving heart and liver functions is provided to prevent damage to heart and liver, and to improve functions of heart and liver. CONSTITUTION: A composition for improving heart and liver functions contains: 10-35 parts by weight of L-carnitine; 1-30 parts by weight of taurine; and vitamins selected from 0.1-5 parts by weight of vitamin E, 0.1-5 parts by weight of coenzyme Q10, and a mixture thereof. The composition can be used for human and animals. Functional food containing the composition is functional drink.

Description

Composition for improving heart and liver function and functional food comprising thererof

The present invention relates to a composition for improving heart and liver function and a functional food comprising the same, and specifically to a composition for improving heart and liver function and a functional food comprising the same, which prevents heart and liver damage and improves heart and liver function. It is about.

The liver is the largest organ in our body and is a very important organ responsible for various metabolism, detoxification, decomposition, synthesis and secretion. The liver functions to defend the body and is more likely to be damaged than other organs because of the risk of exposure to many toxic substances in addition to nutrients. The liver is a good organ with good regenerative capacity and can recover normally if there is some damage. However, if the damage persists, a part of the liver tissue is completely destroyed and liver function is also degraded. If such liver damage is chronicized, liver fibrosis, cirrhosis, and liver cancer occur regardless of the cause. Liver fibrosis, liver cirrhosis, and liver cancer are diseases that do not have clear treatments and treatments at present and their mortality rates are also high. Therefore, prevention and treatment of liver damage before liver damage is chronic is crucial to inhibiting progression to liver fibrosis, cirrhosis, or liver cancer.

The heart, on the other hand, takes blood from the veins and circulates blood throughout the arteries throughout the body. The heart contracts to deliver blood, which causes the myocardium, which is composed of muscles. In this regard, when cardiac myocardial cell disorders occur due to an increase in ventricular load due to hypertension or heart valve syndrome, myocardial infarction, myocarditis, or cardiomyopathy, blood volume may not be sufficiently transmitted to organs of the whole body, resulting in decreased cardiac output and cardiac hypertrophy. The heart is an organ that has been completely differentiated and cannot further cell proliferation. Therefore, if there is a need to increase the cardiac output, the only solution is to increase the size of the existing cardiomyocytes and increase the contractility of the myocardium. This physiological phenomenon is called hypertrophy. . If this myocardial hypertrophy lasts for a certain period of time, it is very likely that it can worsen with heart failure.

The problem to be solved by the present invention is to provide a composition for improving heart and liver function to prevent heart and liver damage and improve heart and liver function.

Another problem to be solved by the present invention is to provide a functional food for improving heart and liver function to prevent heart and liver damage and improve heart and liver function.

The technical objects of the present invention are not limited to the technical matters mentioned above, and other technical subjects not mentioned can be clearly understood by those skilled in the art from the following description.

In order to solve the above problems, the composition for improving heart and liver function according to an embodiment of the present invention includes L-carnitine, taurine, and vitamins selected from vitamin E, coenzyme Q10 or a mixture thereof.

In order to solve the above problems, the functional food for improving heart and liver function according to an embodiment of the present invention includes vitamins selected from L-carnitine, taurine, and vitamin E, coenzyme Q10 or mixtures thereof.

The details of other embodiments are included in the detailed description.

The composition according to the embodiments of the present invention protects the hepatocytes by preventing intracellular penetration of harmful substances and outflow of hepatic intracellular substances.

Compositions according to embodiments of the present invention are effective in improving liver function by promoting regeneration of damaged heart and liver cells.

Compositions according to embodiments of the present invention to prevent heart and liver cells damage by the antioxidant action to protect the heart and liver.

The composition according to the embodiments of the present invention prevents liver damage by inhibiting collagen synthesis and preventing liver fibrosis. The composition of the present invention can be prepared as a variety of foods and the like, regardless of the formulation, it is also possible to use as an additive to a variety of food. Compositions according to the embodiments of the present invention is effective not only for humans, but also for pets such as dogs and cats, and can be prepared as a snack and food for pets.

The effects according to the present invention are not limited to the contents exemplified above, and more various effects are included in the specification.

Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described in detail below. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. To fully disclose the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims.

In the present specification, the singular forms include plural forms unless the context clearly dictates otherwise, and "comprises" and / or "comprising" do not exclude the presence or addition of one or more other constituents.

Hereinafter, the present invention will be described in detail so that those skilled in the art can clearly understand.

The composition for improving heart and liver function according to an embodiment of the present invention further includes L-carnitine (L-carnitine) (A), taurine (B), vitamins (C), and the like. The composition for improving heart and liver function according to an embodiment of the present invention promotes the regeneration of damaged heart and liver cells, and acts as an antioxidant to prevent damage to the liver and heart due to free radicals as well as to improve heart and liver function. It plays a role.

L-carnitine (A) serves to promote the regeneration of heart and liver cells and to improve heart and liver function. L-carnitine (A) is a nutrient required for myocardium, liver and the like, and maintains the health of heart and liver cells and promotes the regeneration of damaged heart and liver cells, thereby contributing to the improvement of heart and liver function. In addition, oxidation in vivo increases free radicals and decreases mitochondrial activity. L-carnitine can reactivate mitochondria to reduce free radicals, which inhibits damage to heart and liver cells by free radicals. Can play a role. In addition, L-carnitine (A) can also affect the metabolism of the heart, thereby improving heart function.

L-carnitine (A) may be included in an amount of 10 to 35 parts by weight based on the composition. When L-carnitine (A) is included in the above range, the effect of improving heart and liver function is excellent.

Taurine (B) has the effect of preventing the myocardial hypertrophy by strengthening the contractile force of the heart muscle, and acts as an antioxidant to neutralize various free radicals in the body can help the liver detoxification. In addition, it protects the heart by changing the intracellular osmotic pressure, and also affects calcium ions that affect the activity and function of myocardial cells, thereby improving heart and liver function. In addition, when taurine (B) is used together with L-carnitine (A), the effect of improving heart and liver function is further improved.

Taurine (B) may be included in an amount of 1 to 30 parts by weight, and specifically 10 to 20 parts by weight, based on the composition. When taurine (B) is included in the above range, L-carnitine (A) may exhibit an excellent effect on improving heart and liver function.

Vitamins (C) may be used alone or a mixture thereof selected from coenzyme Q10 (C-1), vitamin E (C-2), or a mixture thereof.

Coenzyme Q10 (C-1) is also called coenzyme Q10, ubiquinone 10, ubidecarenone or coenzyme UQ10, and is known as 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4 benzoquinone. It is a vitamin-like substance of benzoquinones having the chemical formula. Coenzyme Q10 is found in tissues of animals and plants, specifically endoplasmic reticulum, peroxisomes, lysosomes, and mitochondrial linings. Electron transport systems of mitochondrial membranes include complex I, complex II, complex III, complex IV and two molecules, coenzyme Q10 and cytochrome c. Coenzyme Q10 plays an important role in the production of ATP-type energy in the body by contributing to the transport of electrons and proton transport by delivering reducing equivalents to receptors such as coenzyme Q: cytochrome c oxidoreductase in mitochondrial and bacterial respiration. In charge of. The structure of coenzyme Q10 consists of a quinonehead group and a hydrophobic isoprenoid tail, and a quinone group moves between quinones, semiquinones and hydroquinones and is reversible electron transfer process. Do this.

Coenzyme Q10 (C-1) according to the present invention may be extracted from the heart of an animal such as cow, or may be obtained by a synthesis method or a fermentation method, and is not particularly limited. Coenzyme Q10 (C-1) according to the present invention serves to enhance the cardiovascular disease by enhancing the antioxidant activity of human cells and tissues, in particular used in combination with L-carnitine (A) and taurine (B) If you increase the effect of improving heart function. In addition, it protects the heart and liver by acting to prevent damage of liver cells and heart cells by free radicals by the antioxidant action.

Coenzyme Q10 (C-1) may be included in an amount of 0.1 to 5 parts by weight, more specifically 1 to 5 parts by weight, based on the composition. When contained in an amount of 0.1 to 5 parts by weight to prevent damage to the heart and liver cells and to improve the function, but when contained in less than 0.1 part by weight of the effect is insignificant, when it exceeds 5 parts by weight of lipid solution as well as aqueous solution The low solubility is difficult to formulate, and the absorption in the body may be reduced.

Vitamin E (C-2) promotes the regeneration of damaged heart and liver cells, strengthens the heart muscle, and has an improved effect on preventing angina and improving heart function. In addition, it serves to inhibit the damage of hepatocytes and heart cells from free radicals, and serves to increase the effects of the above-mentioned L-carnitine (A) and taurine (B).

Vitamin E (C-2) according to the present invention vitamin E (D) may be included in 0.1 to 5 parts by weight based on the composition. If included in the above range can increase the effect of improving heart and liver function.

In addition, the composition according to the embodiments of the present invention is vitamin B1, B2, B6, C, niacin, betaine, folate pantothenic acid, biotin, iron, calcium, chromium, zinc and magnesium alone or mixtures thereof It may further include, preferably may further comprise zinc. The substances help to enhance the activity of the body, while helping the active ingredient to exert its effect when combined with the active ingredients.

The vitamin B1, B2, B6, C, niacin, betaine, folate pantothenic acid, biotin, iron, calcium, chromium, zinc and magnesium alone or a mixture thereof may be included in an amount of 0.5 to 1.0 parts by weight based on the composition. have. When included in the above range can increase the effectiveness of the active ingredients, while effectively promoting physical activity.

Compositions for improving heart and liver function according to embodiments of the present invention can be prepared in various formulations, oral or parenteral. When formulated, diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents and surfactants are usually used. Solid form preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, which include at least one excipient in one or more compounds, such as starch, calcium carbonate, sucrose or lactose, gelatin, and the like. Mix to prepare. In addition to the simple excipients, lubricants such as magnesium stearate, talc and the like are also used. Liquid preparations for oral administration include suspensions, solutions, emulsions, and syrups, and various excipients such as wetting agents, sweeteners, fragrances, and preservatives, in addition to mur liquid paraffin, a simple diluent commonly used. have. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilizers, suppositories. As the non-aqueous solvent and the suspension solvent, propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like can be used. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, lautin paper, glycogelatin and the like can be used.

Compositions for improving heart and liver function according to embodiments of the present invention may be prepared in a variety of functional foods. For example, it may be chewing gum, caramel products, candy, ice cream, confectionary, various foods, soft drinks, mineral water, alcoholic beverages, and other functional foods such as vitamins and minerals. It may also be formulated as an oral preparation for pets, specifically pet tablets, capsules, liquids, gels, pastes, oral sprays, oral tablets, powders and chewable treats or animal feeds. It is not limited to this.

Compositions for improving heart and liver function according to embodiments of the present invention may be prepared as food or used with other food ingredients, and may be appropriately used according to conventional methods. The amount of the active ingredient to be mixed may be appropriately determined depending on the intended use.

The functional food of the present invention may contain various flavors or natural carbohydrates as additional ingredients. The above-mentioned natural carbohydrates are sugar alcohols such as monosaccharides such as glucose and fructose, sorbitol and erythritol. Examples of sweeteners include natural sweeteners such as tau Martin and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like. The ratio of the natural carbohydrate is preferably selected in the range of 0.01 to 0.04 parts by weight, preferably about 0.02 to 0.03 parts by weight, per 100 parts by weight of the health functional food of the present invention.

In addition to the above, the functional food of the present invention includes various nutrients, vitamins, electrolytes, flavors, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, And carbonating agents used in carbonated drinks. In addition, the functional food of the present invention may contain fruit flesh for the production of natural fruit juice, fruit juice drink and vegetable drink. These components can be used independently or in combination. The proportion of such additives is not critical but is generally selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the functional food of the present invention.

Compositions for improving heart and liver function and functional foods comprising the same according to embodiments of the present invention are not only humans, but also animals such as cattle, horses, sheep, pigs, goats, camels, antelopes, or pets such as dogs and cats. Can be used. In particular, in the case of cats, since the content of synthesizing taurine in the body is very small compared to dogs, it may exhibit an excellent effect when ingesting the composition and food according to the embodiment of the present invention.

Hereinafter, the present invention will be described more specifically by way of examples. This is for the purpose of illustrating the present invention, and thus the scope of the present invention is not limited thereto.

< Example  1 to 13> Preparation of a composition for improving heart and liver function

To prepare a composition for improving liver protection and liver function by mixing to the composition of Table 1 below. The units in Table 1 are g.

Constituent Example One 2 3 4 5 6 7 8 9 10 11 12 13 L-carnitine 5 10 35 40 35 35 35 35 35 35 35 35 35 Taurine 10 10 10 10 One 30 35 30 30 30 35 35 35 Coenzyme Q10 One One One One One One One 0.1 5 7 One One One vitamin One One One One One One One One One One 0.1 5 7 zinc 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100

< Comparative example  1 to 4> Preparation of a composition for protecting liver and improving liver function

By mixing to the composition of Table 2 to prepare a composition for liver protection and liver function improvement. The unit of Table 2 below is g.

Constituent Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 L-carnitine 65 - 35 35 Taurine - 65 30 30 Coenzyme Q10 One One - One Vitamin E One One One - zinc 0.8 0.8 0.8 0.8 Purified water to 100 to 100 to 100 to 100

< Formulation Example  1> Drink  Produce

The composition of Table 3 was mixed and filled into bottles to prepare a drink. The unit of Table 3 below is mg.

Constituent content L-carnitine 35 Taurine 30 Vitamin E One Coenzyme Q10 One zinc 0.8 Citric acid 2 Purified water To 1000

< Formulation Example  2> Preparation of tablets

The composition of Table 4 was mixed to form granules by adding 40 mg of 30% ethanol, dried at 60 ° C., and purified by tableting. The unit of Table 4 below is mg.

Constituent content L-carnitine 35 Taurine 30 Vitamin E One Coenzyme Q10 One zinc 0.8 Starch 30.0 Magnesium stearate 4.0

< Experimental Example  1> Liver protection and liver function improvement

Example and Comparative Example In order to confirm the effect of improving the liver function of the composition, 5 weeks old healthy rats were selected for each of three compositions to confirm the effect of improving liver function. Carbon tetrachloride (CCl ₄ ) is a hepatotoxic sample that is metabolized by metabolic enzymes such as cytochrome P450, a complex compound in the liver, to form highly reactive free radicals CCl ₃ and Cl, which are free The radical CCl ₃ causes the oxidation of fatty acids in accumulated liver triglycerides or membrane phospholipids and forms organic peroxides through lipid peroxidation. Lipid peroxidation causes fat to accumulate in the liver, and protein synthesis is reduced, resulting in the breakdown of glycogen and destruction of cytoplasmic enzymes in blood vessels, resulting in necrosis of liver tissue. Carbon tetrachloride was orally administered 1.2 ml / kg of body weight to give liver damage to rats, and the compositions of Examples and Comparative Examples were orally administered once daily for 20 days. After 15 days, the results of measuring AST and ALT are shown in Table 5 below. The following initial shows the results after administration of the composition of Examples and Comparative Examples after causing liver damage.

ALT (UI / L) AST (UI / L) division Early After 20 days Early After 20 days Example 1 2540 1356 1452 865 Example 2 2350 532 1395 421 Example 3 2548 551 1362 413 Example 4 2620 1121 1421 824 Example 5 2452 856 1326 612 Example 6 2678 575 1368 401 Example 7 2598 1295 1456 846 Example 8 2612 789 1486 623 Example 9 3451 895 1386 641 Example 10 2398 1198 1374 836 Example 11 2496 782 1442 689 Example 12 2536 798 1423 652 Example 13 2431 1095 1459 813 Comparative Example 1 2512 1752 1368 1120 Comparative Example 2 2621 1750 1346 1230 Comparative Example 3 2533 1502 1462 1023 Comparative Example 4 2413 1496 1376 1089

As shown in Table 5, the oral administration of the compositions of Examples 2, 3 and 6 showed the greatest decrease in ALT and AST activity, and the administration of the composition of Example reduced more than the administration of the composition of Comparative Example. It was. Therefore, it can be seen that the composition of the embodiment has an effect of protecting the liver from liver damage.

< Experimental Example  2> Check the liver protection effect

When the drug is introduced, metabolism occurs in the liver and oxidative action increases to produce lipid peroxides. These lipid peroxides can increase liver damage. In Experimental Example 1, liver tissue was collected to measure lipid peroxides of rats that caused liver damage with carbon tetrachloride. The collected liver tissues were pulverized in physiological saline, and the lipid peroxide malondialdehyde (MDA) was measured according to the ThioBarbituric Acid Reactive Substances (TBARS assay kit) test method. The results are shown in Table 6 below.

division Initial (nmol / ml) 20 days past Example 1 22.3 13.6 Example 2 21.2 9.6 Example 3 23.4 9.2 Example 4 22.1 12.5 Example 5 22.0 11.3 Example 6 22.6 8.9 Example 7 22.4 12.9 Example 8 23.1 10.8 Example 9 22.9 10.9 Example 10 21.9 12.1 Example 11 22.8 10.2 Example 12 22.3 10.6 Example 13 22.5 12.3 Comparative Example 1 22.6 19.3 Comparative Example 2 21.9 18.9 Comparative Example 3 23.1 18.2 Comparative Example 4 22.6 18.3

As shown in Table 6, the composition of the Example was more effective in inhibiting the carbon tetrachloride-induced lipid peroxide production than the composition of the comparative example.

< Experimental Example  3> Check the effect of improving heart function

Improvement in heart function was assessed as an effect on cardiac hypertrophy. Abdominal aortic stenosis was performed surgically on 7 week old male rats (190-200 g). The abdominal aortic stenosis increases systolic blood pressure and increases the cardiac backload, causing hyperventricular hypertrophy. A total of 500 mg of the compositions prepared in Examples and Comparative Examples were administered orally twice a day continuously for 15 days after the surgery from one day before the aortic stenosis. After the end of the experiment, rats were anesthetized, the body weight and hemodynamics of the rats were measured under anesthesia, and the heart was extracted to determine heart weight. The ratio of heart weight to body weight was used as an indicator of cardiac hypertrophy. The results are shown in Table 7 below.

division Weight (g) Heart weight (mg) Heart weight / weight (mg / g) Example 1 230 851 3.70 Example 2 229 635 2.77 Example 3 231 621 2.69 Example 4 228 812 3.56 Example 5 234 752 3.21 Example 6 229 615 2.69 Example 7 226 823 3.64 Example 8 225 763 3.39 Example 9 231 746 3.23 Example 10 229 816 3.56 Example 11 234 739 3.16 Example 12 231 742 3.21 Example 13 224 819 3.66 Comparative Example 1 226 1121 4.96 Comparative Example 2 231 1202 5.20 Comparative Example 3 226 1098 4.86 Comparative Example 4 228 1126 4.94

As shown in Table 7, there was no significant difference in body weight when the composition of the Example was administered and when the composition of the Comparative Example was administered. In addition, the administration of the composition of the comparative example was significantly higher in the weight of the heart than the administration of the composition of the example, while the administration of the composition of the example was relatively small increase in heart weight and suppressed the occurrence of cardiac hypertrophy. I could confirm it.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, You will understand. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

Claims (9)

L-carnitine;
Taurine; And
A composition for improving heart and liver function comprising vitamins selected from vitamin E, coenzyme Q10 or mixtures thereof. The method of claim 1,
The L-carnitine is 10 to 35 parts by weight based on the composition composition for improving heart and liver function. The method of claim 1,
The taurine is a composition for improving heart and liver function is contained in 1 to 30 parts by weight based on the composition. The method of claim 1,
The coenzyme Q10 is 0.1 to 5 parts by weight based on the composition composition for improving heart and liver function. 5. The method of claim 4,
The vitamin E is a composition for improving the heart and liver function is included 0.1 to 5 parts by weight with respect to the composition. The method of claim 1,
Composition for improving heart and liver function that the composition can be applied to humans or animals. The method of claim 1,
Composition for improving heart and liver function further comprising zinc. L-carnitine;
Taurine; And
A functional food for improving heart and liver function comprising vitamins selected from vitamin E, coenzyme Q10 or mixtures thereof. 9. The method of claim 8,
Food for improving heart and liver function wherein the food is a functional drink.