KR20130098038A - Composition for promoting circulation of blood and improving skin disease - Google Patents

Abstract

PURPOSE: A composition for promoting blood circulation and treating skin disorders is provided to promote blood circulation in animals and human and to treat skin disorders. CONSTITUTION: A composition for promoting blood circulation and treating skin disorders contains 30-70 parts by weight of eicosapentaenoic acid (EPA), 20-60 parts by weight of docosahexaenoic acid (DHA), 2-30 parts by weight of vitamin E, and 0.1-10 parts by weight of zinc sulfate.

Description

Composition for promoting circulation of blood and improving skin disease

The present invention relates to a composition for promoting blood circulation and improving skin diseases, and more particularly, for a composition for humans and animals that promotes blood circulation and improves skin diseases.

Blood circulation refers to the phenomenon in which blood flows in an animal's body in a certain direction. It supplies oxygen to each tissue in the body, releases carbon dioxide, supplies nutrients, releases metabolites, and carries hormones from various endocrine glands. The organ regulates the function, and in addition, it is the process of controlling pathogens, controlling body temperature, controlling osmotic pressure, and controlling water. Blood circulation disorder means that blood pumped from the heart returns to the heart through arteries, capillaries, and veins, and blood vessels lose elasticity and cholesterol is deposited on the inner wall, resulting in narrowing of the lumen of the vessels. As modern society has become westernized, blood circulation disorders have caused various diseases and symptoms in various age groups due to poor diet, stress and lack of exercise.

On the other hand, since the skin covers the surface of the body, there are many opportunities for contact with various pathogens such as skin filamentous fungi, Candida, and the like, and are susceptible to infection. easy. Skin disease is a case often encountered in veterinary clinics. Expensive ointments, oral or injectable medications are used for the treatment of skin diseases, and the effects of treatment are temporary and long-term overuse causes damage to other organ tissues. Sometimes.

The problem to be solved by the present invention is to provide a composition for promoting blood circulation and improving skin diseases, which is effective not only to promote blood circulation but also to improve skin diseases and can be applied to both humans and animals.

Another problem to be solved by the present invention is to provide a food for promoting blood circulation and improving skin diseases, which is effective in improving skin diseases as well as promoting blood circulation and applicable to both humans and animals.

The technical objects of the present invention are not limited to the technical matters mentioned above, and other technical subjects not mentioned can be clearly understood by those skilled in the art from the following description.

In order to solve the above problems, the composition for promoting blood circulation and skin disease improvement according to an embodiment of the present invention comprises eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin E and zinc sulfate do.

In order to solve the other problem, food for promoting blood circulation and improving skin diseases according to another embodiment of the present invention 30 to 70% by weight of eicosapentaenoic acid, 20 to 60% by weight of docosahexaenoic acid, vitamins E 2-30 wt% and zinc sulfate 0.1-10 wt%.

The details of other embodiments are included in the detailed description.

The composition for promoting blood circulation and improving skin diseases according to an embodiment of the present invention not only has an excellent ability to promote blood circulation in animals and humans but also has an effect on the treatment of skin diseases.

The composition of the present invention has an effect on relieving inflammation in the skin of animals and humans and has low toxicity to the skin.

The composition of the present invention not only relieves the itch caused by skin infection and provides moisturizing power to the skin, but also exhibits a rapid therapeutic effect due to its excellent regenerative ability.

The composition of the present invention can be prepared in a variety of formulations, regardless of the formulation, and can be used orally, so it can be used as an additive to a variety of food, it can also be prepared as a snack for pets.

The effects according to the present invention are not limited to the contents exemplified above, and more various effects are included in the specification.

Advantages and features of the present invention and methods of achieving them will become apparent with reference to the embodiments described in detail below. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. To fully disclose the scope of the invention to those skilled in the art, and the invention is only defined by the scope of the claims.

In the present specification, the singular forms include plural forms unless the context clearly dictates otherwise, and "comprises" and / or "comprising" do not exclude the presence or addition of one or more other constituents.

Hereinafter, the present invention will be described in detail so that those skilled in the art can clearly understand.

Composition for promoting blood circulation and improving skin diseases according to an embodiment of the present invention includes Eicosapentaenoic acid (EPA) (A). Eicosapentaenoic acid (A) is an essential fatty acid that can be a precursor of prostaglandin and leukotrien in vivo and is a type of unsaturated ω-3 fatty acid. Eicosapentaenoic acid (A) lowers blood cholesterol levels and promotes blood circulation. In addition, eicosapentaenoic acid (A) is effective in the treatment of skin diseases such as psoriasis, itching, inflammation and various skin diseases. Specifically, the skin diseases include fungal skin diseases, ameliorative skin diseases, seborrheic skin diseases, pyoderma, purulent diseases, allergic dermatitis, and the like, which appear in animals. Eicosapentaenoic acid (A) relieves itching and improves inflammation by providing moisture to the skin and improving regeneration. Specifically, pets such as dogs or cats, which are not humans, are covered with hairs, and thus are highly likely to be infected with microorganisms and parasites such as various pathogenic bacteria, fungi and yeasts. Infection with microorganisms or parasites causes itching and damages the skin barrier resulting in accelerated dehydration. Eicosapentaenoic acid (A) regenerates the skin to inhibit dehydration and relieve itching.

Eicosapentaenoic acid (A) may be included in an amount of 30 to 70 parts by weight, and specifically, 40 to 60 parts by weight of the composition. When eicosapentaenoic acid (A) is included in an amount less than 30 parts by weight, the effect of promoting blood circulation and improving skin diseases is excellent. If it exceeds 70 parts by weight, blood lipids and coagulation factors are increased to increase blood circulation effects. It may show a tendency to decrease.

Composition for promoting blood circulation and improving skin diseases according to an embodiment of the present invention includes docosahexaenoic acid (Docosahexaenoic acid, DHA) (B). Docosahexaenoic acid (B), like eicosapentaenoic acid (A), is an essential fatty acid and is a type of unsaturated ω-3 fatty acid. Docosahexaenoic acid (B) inhibits blood coagulation and dilates blood vessels, thereby lowering blood pressure as well as inhibiting blood coagulation, thereby improving blood circulation. In addition, docosahexaenoic acid (B) is effective in improving skin diseases by improving the moisturizing and regenerating power of the skin. That is, because it provides moisture to the skin, itching is alleviated, and regeneration is improved, which is effective in treating inflammation and wounds.

Docosahexaenoic acid (B) may be included in 20 to 60 parts by weight, specifically 30 to 50 parts by weight based on the composition. When docosahexaenoic acid (B) is included in less than 20 parts by weight may not exhibit the effect of promoting blood circulation and improving skin diseases, and in excess of 60 parts by weight may reduce the blood circulation effect, irritating the skin Can cause.

Composition for promoting blood circulation and skin disease improvement according to an embodiment of the present invention includes vitamin E (C). Vitamin E vitamin E) (C) is a type of fat-soluble vitamin, commonly referred to as tocopherol. Vitamin E (C) prevents the oxidation of eicosapentaenoic acid (A) and docosahexaenoic acid (B), and when used with eicosapentaenoic acid (A) and docosahexaenoic acid (B) Further promote blood circulation. In addition, it improves the skin regeneration ability to speed up the healing of wounds, reduce inflammation and leave no scars. Therefore, when vitamin E (C) is used in combination with eicosapentaenoic acid (A) and docosahexaenoic acid (B), the effect of improving skin diseases in animals or humans is increased.

Vitamin E (C) may be included in 2 to 30 parts by weight, specifically 10 to 20 parts by weight based on the composition. If the vitamin E (C) is included in less than 2 parts by weight of the blood circulation and skin disease improvement effects are insignificant, and when included in 30 parts by weight can cause headaches or digestive problems.

Composition for promoting blood circulation and improving skin diseases according to an embodiment of the present invention comprises zinc sulfate (Zinc sulfate, ZnSO ₄ ) (D). Zinc sulfate (D) can reduce the accumulation of cholesterol in the body, thereby improving blood flow, and helps to heal wounds on the skin. In addition, zinc sulfate (D) when used in conjunction with eicosapentaenoic acid (A) and docosahexaenoic acid (B) serves to promote their blood circulation and skin disease improvement efficacy.

Zinc sulfate (D) may be included in an amount of 0.1 to 10 parts by weight, and specifically 1 to 5 parts by weight, based on the composition. If it contains less than 0.1 parts by weight of zinc sulfate (D) may be less effective in promoting blood circulation and improving skin diseases, if contained in more than 10 parts by weight may cause irritation to the skin or digestive problems if taken for a long time have.

Composition for promoting blood circulation and skin disease improvement according to another embodiment of the present invention is eicosapentaenoic acid 30 to 70% by weight, docosahexaenoic acid 20 to 60% by weight, vitamin E 2 to 30% by weight and zinc sulfate 0.1 to 10% by weight. The composition is not only excellent in promoting blood circulation and improving skin diseases, but also does not cause abnormalities in other organ tissues even after long-term use, and has little irritation even when applied directly to skin or mucous membranes.

The composition for promoting blood circulation and improving skin diseases of the present invention may be formulated into various foods, and in particular, general health functions for oral intake such as beverages, gums, tablets, pills, capsules, granulated chocolates, candy, snacks, ice cream, etc. It may be formulated in the form of a food. It may also be formulated as an oral preparation for pets, specifically pet tablets, capsules, liquids, gels, pastes, oral sprays, oral tablets, powders and chewable treats or animal feeds. It is not limited to this. In formulating, diluents or excipients such as fillers, extenders, binders, moisture agents, disintegrants, surfactants, etc. which are generally used may be used, and starch, calcium carbonate, sucrose, lactose or gelatin may be used as excipients. In addition, lubricants, such as magnesium stearate talc, can be used.

The composition for promoting blood circulation and improving skin diseases of the present invention may be formulated as an external preparation for skin in the form of an ointment, cream, emulsion, plaster, powder, impregnation pad, solution, gel, spray, lotion or suspension applied to the skin and mucous membranes. have. At this time, in addition to the above-mentioned active ingredient for administration may comprise at least one carrier. As the carrier, saline, sterile water, Ringer's solution, buffered saline, dextrose solution, maltodextrin solution, glycerol and ethanol alone or mixtures thereof may be used, and antioxidants, buffers, bacteriostatic agents, etc. may be used as necessary. Other conventional additives can be added. It may also be formulated by additionally adding diluents, dispersants, surfactants, binders and lubricants.

Compositions for the treatment and prevention of skin infections of the invention may be prepared as cosmetic compositions. The cosmetic composition of this invention can mix | blend the various components normally used for cosmetics in the range which does not impair the objective of this invention other than the said component. Specifically, For example, natural animal and vegetable oils, such as lanolin and squalene, higher alcohols, such as stearyl alcohol and isostearyl alcohol, moisturizing agents, such as glycerin and hyaluronic acid, vitamin C, a ultraviolet absorber, a ultraviolet shield, a preservative, a viscosity modifier, Pigments, fragrances and the like may be blended in any amount as required by those skilled in the art. The cosmetic composition may have a formulation such as lotion, cream, cleansing cream, cleansing foam, cleansing water, powder, essence, pack, ointment, soap or shampoo. Of course, it can be made of a cosmetic composition that is applied to humans as well as animals.

Hereinafter, the present invention will be described more specifically by way of examples. This is for the purpose of illustrating the present invention, and thus the scope of the present invention is not limited thereto.

< Example  1 to 17> Preparation of a composition for promoting blood circulation and improving skin diseases

By mixing to the compositions of Tables 1 and 2 to prepare a composition for promoting blood circulation and improving skin diseases. The units of Tables 1 and 2 below are g.

Example One 2 3 4 5 6 7 8 9 EPA 25 30 40 60 70 75 40 40 40 DHA 65 20 20 20 20 15 30 50 60 Vitamin E 2 2 2 2 2 2 2 2 2 Zinc sulfate One One One One One One One One One Purified water To
100 To
100 To
100 To
100 To
100 To
100 To
100 To
100 To
100

Example 10 11 12 13 14 15 16 17 EPA 40 40 40 40 40 40 40 40 DHA 30 30 30 30 30 30 30 30 Vitamin E 10 20 30 32 1.5 2 2 2 Zinc sulfate One One One One One 5 0.1 10 Purified water To
100 To
100 To
100 To
100 To
100 To
100 To
100 To
100

< Comparative example  1 to 4> Preparation of a composition for promoting blood circulation and improving skin diseases

By mixing to the composition of Table 3 to prepare a composition for promoting blood circulation and improving skin diseases. The unit of Table 3 below is g.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Eicosapentaenoic Acid (EPA) - 60.0 30.0 30.0 Docosahexaenoic Acid (DHA) 60.0 - 30.0 30.0 Vitamin E 10.0 10.0 - 10.0 Zinc sulfate 1.0 1.0 1.0 - Purified water to 200 to 200 to 200 to 200

< Manufacturing example  1> Drink  Produce

The composition of Table 3 was mixed and filled into bottles to prepare a drink. The unit of Table 4 below is mg.

Constituent content Eicosapentaenoic Acid (EPA) 30.0 Docosahexaenoic Acid (DHA) 30.0 Vitamin E 10.0 Zinc sulfate 1.0 Citric acid 2.0 Purified water To 100

< Manufacturing example  2> Preparation of tablets

The composition of Table 5 was mixed to form granules by adding 40 mg of 30% ethanol, dried at 60 ° C., and purified by tableting. The unit of Table 4 below is mg.

Constituent content Eicosapentaenoic Acid (EPA) 30.0 Docosahexaenoic Acid (DHA) 30.0 Vitamin E 10.0 Zinc sulfate 1.0 Starch 30.0 Magnesium stearate 4.0

< Manufacturing example  3> Manufacture of gum

To prepare a gum for promoting blood circulation and improving skin diseases with the composition of Table 6. The unit of Table 6 below is mg.

Constituent content Eicosapentaenoic Acid (EPA) 30.0 Docosahexaenoic Acid (DHA) 30.0 Vitamin E 10.0 Zinc sulfate 1.0 Gum base 20 Party 67.0 Spices 1.0 water 2.0

< Manufacturing example  3> Preparation of skin external ointment

To the skin ointment was prepared in the composition of Table 7. Specifically, as shown in Table 4, after mixing the constituents in the cream base containing an oil component, an aqueous component, a surfactant, etc., emulsify well in a mixer, degassing, filtration and cooling, and then add flavoring and coloring as additives, Ointments were prepared in oil / water so that small amounts of oily components were present. The unit in Table 7 below is mg.

Constituent content Eicosapentaenoic Acid (EPA) 300 Docosahexaenoic Acid (DHA) 300 Vitamin E 100 Zinc sulfate 10 vaseline 100 Stearyl alcohol 100 Propylene glycol 50 Sodium lauryl sulfate 15 Methyl paraben 0.2 Profile paraben 0.2 Spices Proper amount Pigment Proper amount Purified water to 1000

< Experimental Example  1> Determination of platelet aggregation inhibitory activity

After beagle dogs were orally ingested the compositions prepared in Examples 1 to 17 and Comparative Examples 1 to 4 for 5 days, blood was collected for each administration time. Blood collected was treated with 0.38% sodium citrate to inhibit coagulation. The platelet rich plasma (PRP) layer obtained by centrifugation of blood was added to collagen as an agonist using a platelet aggregation ability analyzer and tracing the light transmittance for 4 minutes to observe the aggregation of blood. Platelet aggregation inhibitory activity was calculated by making platelet aggregation rate 100% before administration of a composition. The results are shown in Table 8 below.

division Aggregation ratio (%) Example 1 92 Example 2 80 Example 3 72 Example 4 73 Example 5 85 Example 6 93 Example 7 71 Example 8 72 Example 9 84 Example 10 74 Example 11 75 Example 12 84 Example 13 91 Example 14 90 Example 15 72 Example 16 84 Example 17 85 Comparative Example 1 102 Comparative Example 2 100 Comparative Example 3 96 Comparative Example 4 98

According to Table 8, the composition of the example containing both eicosapentaenoic acid (EPA) and docohexaenoic acid (DHA) had better platelet aggregation activity than the compositions of Comparative Examples 1 and 2 using only one of them. . Therefore, when both eicosapentaenoic acid (EPA) and docohexaenoic acid (DHA) are used, it can be seen that the effect of promoting blood circulation is superior to that of using alone. In addition, the compositions of Comparative Examples 3 and 4, which did not contain vitamin E or did not contain zinc sulfate, were also poor in platelet aggregation activity compared with Examples. In addition, it contains 30 to 70% by weight of eicosapentaenoic acid (EPA), especially 40 to 60% by weight, and 20 to 60% by weight of docohexaenoic acid (DHA), in particular 30 to 50% by weight. The composition was excellent in the effect.

< Experimental Example  2> Skin Infectious Disease Treatment Test Using Hairless Mouse

Staphylococcus hairless mouse aureus , Candida albicans , Microsporium canis And infection with yeast causing erythema and inflammation, and the compositions prepared in Examples and Comparative Examples were orally administered to the infected sites. In the method of oral administration, the compositions prepared in Examples and Comparative Examples were ingested with 2 mg of the hairless mice three times each day. The skin condition was observed every 24 hours after ingestion.

As a result of the experiment, in the case of the oral administration of the composition of the Example, inflammation subsided after 24 hours and erythema was alleviated. On the other hand, in the oral administration of the composition of the comparative example, the erythema tended to alleviate only after 48 hours, and there was still inflammation after 120 hours. In addition, no toxicity was seen in hairless mice during the test.

< Experimental Example  3> Determination of dermatitis treatment effect in dogs

Experiments were performed with six domestic dogs of the same household selected. In the experiment, both animals showed a number of clinical signs of dermatitis, especially strong itching, ie scratching, biting, alopecia in the tail, and the like. Six dogs () were fed the same food and were allowed to live together under the same conditions. In dogs, the compositions prepared in Examples and Comparative Examples were each fed with 10 ml each with food. Two dogs were fed with the compositions of Examples 10 and 11, respectively, with food, and the other four dogs were fed with the compositions of Comparative Examples 1-4, respectively, with food. Skin condition was observed every 24 hours. It was. As a result of the experiment, the dogs orally administered the composition of the example, the inflammation subsided after 6 hours, the itch was alleviated, and after 120 hours, the skin condition was almost completely cured, and the hair loss symptoms were also alleviated. On the other hand, all four dogs orally administered with the composition of Comparative Example tended to relieve itching after 48 hours, and there was still inflammation after 120 hours. In addition, there was no toxicity to the dogs during the test. As described above, dogs ingesting the composition of the Example relieved itching in less time than dogs ingesting the composition of the Comparative Example, while other dermatitis symptoms were alleviated. can see.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, You will understand. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

Claims (10)

Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin E and a composition for promoting blood circulation, including zinc sulfate, a composition for improving skin diseases. The method of claim 1,
A composition for promoting blood circulation and improving skin diseases, wherein the eicosapentanic acid is included in an amount of 30 to 70 parts by weight based on the composition. The method of claim 1,
The docosahexaenoic acid is 20 to 60 parts by weight based on the composition for promoting blood circulation and skin disease composition. The method of claim 1,
The vitamin E is a composition for promoting blood circulation and skin diseases comprising 2 to 30 parts by weight with respect to the composition. The method of claim 1,
The zinc sulfate is 0.1 to 10 parts by weight based on the composition for promoting blood circulation and improving skin diseases. The method of claim 1,
30 to 70% by weight of the eicosapentanic acid, 20 to 60% by weight of the docohexaenoic acid, 2 to 30% by weight of the vitamin E, and 0.1 to 10% by weight of zinc sulfate to promote blood circulation and improve skin diseases Composition. The method of claim 1,
Composition for promoting blood circulation and improving skin disease, wherein the composition is an oral preparation. The method of claim 7, wherein
A composition for promoting blood circulation and improving skin diseases, wherein the composition is administered to an animal. Promotes blood circulation and skin diseases including 30 to 70% by weight of eicosaptannoic acid (EPA), 20 to 60% by weight of docosahexaenoic acid (DHA), 2 to 30% by weight of vitamin E and 0.1 to 10% by weight of zinc sulfate Improvement foods. 10. The method of claim 9,
Food for promoting blood circulation and improving skin diseases wherein the food is an animal food.