KR20130088002A - 항-감염성 피리도(1,2-ａ)피리미딘 - Google Patents

항-감염성 피리도(1,2-ａ)피리미딘 Download PDF

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Publication number
KR20130088002A
KR20130088002A KR1020127018472A KR20127018472A KR20130088002A KR 20130088002 A KR20130088002 A KR 20130088002A KR 1020127018472 A KR1020127018472 A KR 1020127018472A KR 20127018472 A KR20127018472 A KR 20127018472A KR 20130088002 A KR20130088002 A KR 20130088002A
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KR
South Korea
Prior art keywords
nmr
mhz
pyrido
heteroaryl
alkyl
Prior art date
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KR1020127018472A
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English (en)
Korean (ko)
Inventor
노재성
김재승
프리실 브로딘
서민정
박은정
조나단 시세토
전희경
아우구스트 제노베시오
이새연
강선희
패니 앤 이완
남지연
데니스 필립 세드릭 페니스테인
티에리 크리스토퍼
도밍구에즈 모니카 콘트레라스
김은혜
허잠웅
Original Assignee
재단법인 한국파스퇴르연구소
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 재단법인 한국파스퇴르연구소, 인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸) filed Critical 재단법인 한국파스퇴르연구소
Publication of KR20130088002A publication Critical patent/KR20130088002A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
KR1020127018472A 2010-01-13 2011-01-13 항-감염성 피리도(1,2-ａ)피리미딘 KR20130088002A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29455210P 2010-01-13 2010-01-13
US61/294,552 2010-01-13
PCT/EP2011/000135 WO2011085990A1 (en) 2010-01-13 2011-01-13 Anti - infective pyrido (1,2 -a) pyrimidines

Publications (1)

Publication Number Publication Date
KR20130088002A true KR20130088002A (ko) 2013-08-07

Family

ID=43610218

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127018472A KR20130088002A (ko) 2010-01-13 2011-01-13 항-감염성 피리도(1,2-ａ)피리미딘

Country Status (9)

Country Link
US (1) US20130012506A1 (pt-PT)
EP (1) EP2523956A1 (pt-PT)
JP (1) JP2013517233A (pt-PT)
KR (1) KR20130088002A (pt-PT)
CN (1) CN102812023A (pt-PT)
AU (1) AU2011206761A1 (pt-PT)
BR (1) BR112012017473A2 (pt-PT)
CA (1) CA2786329A1 (pt-PT)
WO (1) WO2011085990A1 (pt-PT)

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* Cited by examiner, † Cited by third party
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MX354074B (es) 2012-02-10 2018-02-12 Ptc Therapeutics Inc Compuestos para tratar la atrofia muscular espinal.
BR112014021531B1 (pt) 2012-03-01 2022-10-04 Ptc Therapeutics, Inc. Composto, composição farmacêutica e usos dos mesmos
US9914722B2 (en) 2012-03-23 2018-03-13 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
EP3082820B1 (en) 2013-12-19 2022-07-20 PTC Therapeutics, Inc. Methods for modulating the amount of rna transcripts
CA2968090A1 (en) * 2014-12-02 2016-06-09 Prana Biotechnology Limited 4h-pyrido[1,2-a]pyrimidin-4-one compounds
WO2016196386A1 (en) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Methods for modulating rna splicing
CN105153151A (zh) * 2015-08-28 2015-12-16 张文莲 一种嘧啶酮类化合物的合成方法
ES2879995T3 (es) 2015-12-10 2021-11-23 Ptc Therapeutics Inc Métodos para el tratamiento de la enfermedad de Huntington
US11702646B2 (en) 2016-11-28 2023-07-18 Ptc Therapeutics, Inc. Methods for modulating RNA splicing
EA201992878A1 (ru) 2017-06-05 2020-05-08 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения болезни хантингтона
CN111372611A (zh) 2017-06-14 2020-07-03 Ptc医疗公司 修饰rna剪接的方法
BR112019027717A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
MX2019015580A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
CN112135815A (zh) 2018-03-27 2020-12-25 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
EP3814360A1 (en) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
AU2019294478B2 (en) 2018-06-27 2023-03-23 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease
CN114106000B (zh) * 2021-12-15 2023-11-24 中国科学院新疆理化技术研究所 一种咪唑并[4,5-d]嘧啶酮三环类衍生物及抗肿瘤用途

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4603044A (en) 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
US4957773A (en) 1989-02-13 1990-09-18 Syracuse University Deposition of boron-containing films from decaborane
US7176313B2 (en) * 2000-02-09 2007-02-13 Daiichi Pharmaceutical Co., Ltd. Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
EP2219646A4 (en) * 2007-12-21 2010-12-22 Univ Rochester METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS
CA2727651C (en) * 2008-06-17 2016-04-05 Priscille Brodin Anti-infective compounds
WO2010001366A1 (en) * 2008-07-04 2010-01-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Piperazines derivatives as proteasome modulators

Also Published As

Publication number Publication date
CN102812023A (zh) 2012-12-05
AU2011206761A2 (en) 2012-12-13
WO2011085990A1 (en) 2011-07-21
EP2523956A1 (en) 2012-11-21
JP2013517233A (ja) 2013-05-16
CA2786329A1 (en) 2011-07-21
AU2011206761A1 (en) 2012-07-12
WO2011085990A8 (en) 2012-10-26
US20130012506A1 (en) 2013-01-10
BR112012017473A2 (pt) 2019-09-24

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