KR20130055427A - A injection for antifebrile and a manufacturing method thereof - Google Patents

Abstract

PURPOSE: An antipyretic injection solution containing healthy soy sauce as an active ingredient is provided to enhance immunity and to ensure excellent antipyretic and detoxifying effects. CONSTITUTION: A method for manufacturing an antipyretic injection solution comprises: a step of preparing a meju(Korean fermented soybean lump) using Rhynchosia volubilis and wheat flour; a step of maturing the meju and preparing healthy soy sauce; and a step of filtering the healthy soy sauce with a microfilter. The method for also comprises a step of mixing 100 parts by weight of the healthy soy sauce and 1-20 parts by weight of one or more extracts selected from the group consisting of an antler extract, an apricot seed extract, an aromatic tree extract, and a wood-cultivated ginseng extract. Bamboo salt water is prepared by dissolving 20-30 parts by weight of bamboo salt in 100 parts by weight of a nutrient solution. The nutrient solution is prepared by mixing 5-10 parts by weight of sulfur-containing duck, 5-10 parts by weight of garlic, and 3-5 parts by weight of Ulmus pumila in 100 parts by weight of water, and boiling at 90-110 deg. C for 20-28 hours.

Description

Injection solution for antipyretic and its manufacturing method {A injection for antifebrile and a manufacturing method

The present invention relates to an antipyretic injection solution and a method for preparing the same, and more particularly, to enhance immunity, antipyretic, and detoxification effect, which comprises a small intestine ripened in saline with meju made using rats and wheat flour as an active ingredient. An antipyretic injection solution and a method for producing the same.

The environmental pollution caused by the rapid industrialization, the busy daily life and stressful environment of the modern people, and the westernized diet have drastically reduced the immunity of the modern people. In particular, the defense function of a person with general immunity is rapidly deteriorated under various stresses and fatigues, causing infection by weak bacteria, and the incidence of chronic diseases in modern people is also increasing rapidly. In the past five years, major chronic disease growth rates in Korea showed an increase in hyperlipidemia 93%, cerebrovascular disease 34%, hypertension 27%, diabetes 20%, and cardiovascular disease 17% (Health Insurance Review and Assessment Service 2011 National Audit Report) It shows that the health of modern people is greatly threatened.

In order to solve these problems, various nutritional supplements supplementing nutrients insufficient for the human body or health functional foods processed with functional ingredients useful for the human body have been introduced and used easily in the form of oral supplementation. However, it is difficult for consumers who purchase products to systematically obtain the right nutritional information, causing problems such as abuse of supplements or blindness as specialty drugs. In addition, these foods are not a therapeutic agent because of the strong nature of the supplement, do not eliminate the toxins that cause the underlying disease, and had a disadvantage that it is difficult to expect a clear effect in a short time.

In order to improve these problems, processing methods for easy use of natural fermented foods that are effective for anti-inflammatory and detoxification, extraction of active ingredients from natural substances, and nutritional substances in the form of injectables have a rapid effect on the human body. The method has been proposed.

Korean Patent Laid-Open Publication No. 2002-0017482 (2002.03.07.) Discloses an immune antibody enhancer that is processed by injection of nutritional substances necessary for enhancing immunity, and Korean Patent Registration No. 0894029 (2009.04.22.) Has a ginseng flower. Disclosed is a pharmaceutical composition that is processed to be injected into the human body for the purpose of antidiabetic treatment, and an anti-inflammatory, analgesic injection composition containing a fraction of human light such as Korean Patent Registration No. 0834966 (2008.06.03.) Is disclosed. It is.

On the other hand, the present inventor has disclosed a method of manufacturing a sarijang slightly in Korean Patent Registration No. 10-0496531 (2005.06.22.).

The present inventors have developed an injection solution to improve the slight intestine to have immunity enhancement, antipyretic and detoxification efficacy.

KR 10-2002-0017482 (publication number) 2002.03.07 KR 10-0894029 (registration number) 2009.04.22 KR 10-0834966 (registration number) 2008.06.03 KR 10-0496531 (registration number) 2005.06.22

It is an object of the present invention to provide an antipyretic injection solution for preparing immunity, antipyretic and detoxification, and a method of preparing the same, including a little intestine aged in jujube brine using bamboo shoots and flour as an active ingredient.

In order to achieve the above object, the present invention provides the following means.

The present invention, making the meju using rat eye and wheat flour, the step of aging the meju in bamboo brine to prepare a little jang (step 1); And filtering the slight field with a microfilter to prepare an injection solution (step 2); It provides a method for producing an antipyretic injection solution comprising a.

After step 1, 1 to 20 parts by weight of any one or more extracts selected from the group consisting of antler extract, apricot seed extract, fragrance extract and goat ginseng extract may be added to 100 parts by weight of the long sheet.

In the step 1, the jangjang, the soybeans are soaked in water and then pulverized, and then mixed with 8 to 12 parts by weight of flour with respect to 100 parts by weight of the crushed soybeans (S1); After cooling the rat eye bean rice cake at 30 ~ 40 ℃, spreading the rat eye bean rice cake to 20 ~ 40 cm thick (S2); Sprinkling the powdered sulfur soup on the rat eye bean rice cake, covering the cover cloth for 8 to 12 hours to prepare meju (S3); Removing the cover cloth and spreading the meju to 8-12 cm thickness and fermenting the meju for 18-72 hours (S4); Drying the fermented meju for 1 to 3 days (S5); Putting the dried meju into bamboo brine and aging for 15 to 80 days to prepare a little jang (S6); And filtering and sterilizing the prepared jangjang (S7); Characterized in that it is prepared to include.

In the step S6, the bamboo salt is prepared by dissolving 20 to 30 parts by weight of bamboo salt in 100 parts by weight of nutrient solution, the nutrient solution is 5 to 10 parts by weight of sulfur duck, 5 to 10 parts by weight of garlic and 3 to 5 Part by weight, characterized in that to boil at 90 ~ 110 ℃ for 20 to 28 hours.

In another aspect, the present invention provides an antipyretic injection solution characterized in that the production method.

Injectable solution according to the present invention contains a little chapter ripened in bamboo salt brine meju made using rat bean and wheat flour as an active ingredient, excellent immunity enhancement, antipyretic and detoxification effect.

In addition, since the injection solution according to the present invention contains only natural components, there is no side effect, and it is effective to relieve toxins that cause the underlying disease. Since the composition of the present invention is processed in the form of an injection solution, it can be directly administered to blood vessels. The high heat can be lowered quickly.

Hereinafter, the present invention will be described in detail.

First, the preparation method of an injection liquid composition according to the present invention will be described.

Method for producing an injection liquid composition of the present invention,

Making meju using mouse eye beans and flour, and preparing the soybeans by ripening the meju in bamboo brine (step 1); And

Filtering the slight field with a microfilter to prepare an injection solution (step 2);

.

In step 1, the slight length is,

After the soybeans are soaked in water and pulverized, and mixed with 8 to 12 parts by weight of flour with respect to 100 parts by weight of the pulverized soybeans (S1);

After cooling the rat eye bean rice cake at 30 ~ 40 ℃, spreading the rat eye bean rice cake to 20 ~ 40 cm thick (S2);

Sprinkling the powdered sulfur soup on the rat eye bean rice cake, covering the cover cloth for 8 to 12 hours to prepare meju (S3);

Removing the cover cloth and spreading the meju to 8-12 cm thickness and fermenting the meju for 18-72 hours (S4);

Drying the fermented meju for 1 to 3 days (S5);

Putting the dried meju into bamboo brine and aging for 15 to 80 days to prepare a little jang (S6); And

Filtering and sterilizing the prepared small field (S7); It is prepared to include.

In the step S1, after the soybean is soaked in water for 3 to 10 hours, and then pulverized, and mixed with 8 to 12 parts by weight of flour with respect to 100 parts by weight of the pulverized bean, steamed for 1 to 3 hours at 90 to 100 ° C. Steamed mouse eye bean rice cake manufacturing step.

The step S2 is to cool the rat eye bean rice cake at 30 ~ 40 ℃, then unfold the rat eye bean rice cake in a 20 ~ 40 cm thick in an ondol room of 30 ~ 37 ℃.

The step S3 is a step of preparing meju by sprinkling 0.5 to 1 parts by weight of the yellow powdered soybean paste evenly with respect to 100 parts by weight of the rat's eye bean cake, and covering 30 to 37 ℃ for 8 to 12 hours.

The step S4 is to remove the cover cloth and spread the meju to 8 ~ 12 ㎝ thickness and add moisture, and when the surface of the meju starts to dry and harden, add moisture at intervals of 2-6 hours to ferment the meju for 18-72 hours. to be.

The step S5 is a step of drying the fermented meju for 1 to 3 days at a temperature of 20 ~ 35 ℃.

In step S6, 5 to 10 parts by weight of sulfur ducks, 5 to 10 parts by weight of garlic, and 3 to 5 parts by weight of rooted roots, boiled at 90 to 110 ° C. for 20 to 28 hours, and then remove oil and sediment. To prepare a nutrient solution, add 20-30 parts by weight of the dried meju to 100 parts by weight of 100 parts by weight of bamboo salt brine dissolved 20-30 parts by weight of the nutrient solution, and aged for 40 to 80 days at 10-30 ℃ to prepare a few pieces It's a step.

The bamboo salt is pulverized sun salt and chopped into bamboo and the inlet is sealed with ocher, and then placed in an iron container made of ocher between two layers of iron plate, and baked 9 times with pine wood fire to make bamboo salt.

The S7 step is a step of sterilizing for 1 to 2 hours at 90 ~ 110 ℃ after filtering the dried meju, such as meju in a few sheets prepared.

In the method of manufacturing a slightly long sarisjang filed by the present inventors (10-0496531), barley flour was mixed with rat eye, and meju was prepared using Baekkukyun powder. Hwangkukyun powder was used instead of Baekkukyun powder. In addition, the present invention did not include lacquer in step S6.

After step 1, 1 to 20 parts by weight of any one or more extracts selected from the group consisting of antler extract, apricot seed extract, fragrance extract and goat ginseng extract may be added to 100 parts by weight of the long sheet.

The antler is preferably solvent extraction but may be hot water extraction. The solvent for extraction is water, alcohol or mixtures thereof, 5 to 95% by weight of water and 95 to 5% by weight of alcohol and the alcohol is preferably ethanol. The antler is a horn of a deer dried in the shade is effective in body tonic and disease prevention.

The apricot seed is also preferably solvent extraction in the same manner as above but may be hot water extraction. The apricot seed helps to asthma or relieve, chronic bronchitis and is effective in female diseases.

The fragrance is preferably 5 to 10 parts by weight of 100% by weight purified water to extract hot water for 1 to 3 hours at 90 ~ 110 ℃. The juniper means the native juniper used as a medicine in Oriental medicine.

The mountain goat is also preferably hot water extraction in the same manner as described above. Ginseng or red ginseng may be used instead of the goat. The wild ginseng is a ginseng seeded with artificial ginseng seedlings or seedlings transplanted under the forest of the mountain ginseng, lowering hyperglycemia, improving metabolic disorders, and detoxifying toxic substances and alcohols.

Step 2 is a step of preparing an antipyretic injection solution by filtering the small length using a micro filter.

The present invention also provides an antipyretic injection solution prepared by the above method.

The antipyretic injection solution according to the present invention can be diluted with sterile distilled water or physiological saline for injection.

The antipyretic injection solution according to the present invention fundamentally eliminates the toxins causing the disease and has immunity enhancement, antipyretic and detoxification effects. In addition, since the composition of the present invention is processed in the form of an injection solution, it can be directly administered to blood vessels, so that high fever can be lowered quickly.

The antipyretic injection solution according to the present invention has an advantage of enhancing the immunity and shortening the antipyretic and detoxification effect in a short time when administered to a person with reduced immunity or chronic disease.

Hereinafter, the constitution and effects of the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, but the scope of the present invention is not limited by these examples.

The rat eye bean was soaked in water for 5 hours and then pulverized. After mixing 10 parts by weight of wheat flour with 100 parts of the pulverized bean bean, the rat bean rice cake was prepared by steaming for 3 hours at 100 ° C.

After cooling the rat eye bean rice cake at 35 ℃, the rat eye bean rice cake was spread in a 35cm ondol room to 30cm thick.

0.5 parts by weight of sulfur bacteria was evenly sprayed with respect to 100 parts by weight of the rat's eye bean cake, and covered with a cover cloth to maintain 35 ° C. for 10 hours to prepare meju.

The cover cloth was removed, and the meju was spread out to a thickness of 10 cm and water was added thereto. After 18 hours, the meju was fermented for 18 hours by adding water at intervals of 2 hours.

The fermented meju was dried at a temperature of 25 ° C. for 3 days.

10 parts by weight of sulfur duck, 10 parts by weight of garlic and 5 parts by weight of root skin were added to 100 parts by weight of water, and boiled at 100 ° C. for 24 hours, and oil and precipitate were removed to prepare a nutrient solution.

Bamboo salt was prepared by dissolving 25 parts by weight of bamboo salt in 100 parts by weight of the nutrient solution.

25 parts by weight of the dried meju was added to 100 parts by weight of the brine, and aged at a temperature of 10 to 30 ° C. for 60 days to prepare a slight length.

The pickles were picked from the slightly intestine and sterilized at 100 ° C. for 1 hour.

The bamboo salt was prepared by crushing the natural salt, chopped into bamboo, sealed the inlet with ocher, and then placed in an iron bucket made of ocher between two layers of iron plates, and baked 9 times with pine wood fire.

The sterilized some sheets were filtered with a 0.45 μm filter to prepare an antipyretic injection solution.

0.5 part by weight of the antipyretic injection solution was diluted with 100 parts by weight of sterile distilled water, and used in Experimental Examples 1 and 2 below.

The rest was prepared in the same manner as in Example 1, except that 100 parts by weight of sterile chapter 2 parts by weight of a deer antler extract, 1 part by weight of apricot seed extract, 1 part by weight of cedar extract and 1 part by weight of goat ginseng extract.

The antler extract was obtained by adding 1 kg of dried antler powder to 2 L of an aqueous 70% ethanol solution and extracting at room temperature for 2 days, filtering the solution with filter paper after 2 days, and then removing ethanol.

The apricot seed extract was also obtained by solvent extraction in the same manner as above.

The fragrance extract was added to 100 parts by weight of purified water 5 parts by weight of cedar and obtained by hot water extraction for 3 hours at 100 ℃.

Goat ginseng extract was also obtained by hot water extraction in the same manner as above.

Comparative Example 1

The antipyretic injection solution of D company was purchased and used.

[Experimental Example 1]

Side effects tests were performed on the injection solutions prepared in Examples 1 and 2. 10 mg of the injection solution of Example 1 and 2 was administered to 10 persons, respectively, in healthy people who did not have a specific disease of 20 to 40 years, and the results are shown in Table 1.

[Inspection Criteria]

-: No side effect

±: mild side effects (beats)

+: Side effects (itch, itching)

++: strong side effects (erythema, itching, palpitations)

+++: severe side effects (vomiting, dizziness, erythema, itching, palpitations)

division Number of test persons (persons) Judgment result - ± + ++ +++ Example 1 10 10 0 0 0 0 Example 2 10 10 0 0 0 0

Looking at Table 1, it can be seen that the injection solution prepared in Examples 1 and 2 did not show any side effects.

[Experimental Example 2]

An efficacy test was performed on the injection solutions prepared in Examples 1 and 2 above. Thirty hyperthermia patients aged 20 to 40 years were administered to 10 patients, each of whom received the injection solution prepared in Example 1 and 2 and 2 mg of the injection solution purchased in Comparative Example 1, and observed changes in body temperature up to 180 minutes. The results are averaged and shown in Table 2.

Time (min) Example 1 (° C) Example 2 (° C) Comparative Example 1 (° C) 0 38.9 ± 0.3 39.1 ± 0.4 38.8 ± 0.3 60 37.2 ± 0.3 37.3 ± 0.3 38.4 ± 0.4 120 36.9 ± 0.2 37.0 ± 0.2 38.0 ± 0.1 180 36.6 ± 0.1 36.6 ± 0.1 37.5 ± 0.1

Looking at Table 2, it can be seen that the antipyretic injection solutions prepared in Examples 1 and 2 show an excellent antipyretic effect compared to the injection solutions of Comparative Example 1.

Claims (5)

Making meju using mouse eye beans and flour, and preparing the soybeans by ripening the meju in bamboo brine (step 1); And
Filtering the slight field with a microfilter to prepare an injection solution (step 2);
Method for producing an antipyretic injection solution comprising a.
The method of claim 1, wherein after step 1,
Method for producing an antipyretic injection solution, characterized in that the step of adding 1 to 20 parts by weight of any one or more extracts selected from the group consisting of antler extract, apricot seed extract, cedar extract and goat ginseng extract per 100 parts by weight .
The method according to claim 1, wherein in step 1, the slight length is
After the soybeans are soaked in water and pulverized, and mixed with 8 to 12 parts by weight of flour with respect to 100 parts by weight of the pulverized soybeans (S1);
After cooling the rat eye bean rice cake at 30 ~ 40 ℃, spreading the rat eye bean rice cake to 20 ~ 40 cm thick (S2);
Sprinkling the powdered sulfur soup on the rat eye bean rice cake, covering the cover cloth for 8 to 12 hours to prepare meju (S3);
Removing the cover cloth and spreading the meju to 8-12 cm thickness and fermenting the meju for 18-72 hours (S4);
Drying the fermented meju for 1 to 3 days (S5);
Putting the dried meju in bamboo brine and aging for 15 to 80 days to prepare a little jang (S6); And
Filtering and sterilizing the prepared small field (S7);
Method for producing an antipyretic injection solution characterized in that it is prepared to include.
The method of claim 3, wherein in step S6,
The bamboo salt is prepared by dissolving 20 to 30 parts by weight of bamboo salt in 100 parts by weight of nutrient solution, the nutrient solution is 5 to 10 parts by weight of sulfur duck, 5 to 10 parts by weight of garlic and 3 to 5 parts by weight of root skin, Method for producing an antipyretic injection solution, characterized in that to boil at ~ 90 ~ 110 ℃ for 28 hours.
An antipyretic injection solution, which is prepared by the method according to any one of claims 1 to 4.