KR20130018407A - 바이러스-유사 입자에 커플링된 아밀로이드 베타 1-6 펩티드 및 아주반트를 포함하는 조성물 - Google Patents

바이러스-유사 입자에 커플링된 아밀로이드 베타 1-6 펩티드 및 아주반트를 포함하는 조성물 Download PDF

Info

Publication number
KR20130018407A
KR20130018407A KR1020127025613A KR20127025613A KR20130018407A KR 20130018407 A KR20130018407 A KR 20130018407A KR 1020127025613 A KR1020127025613 A KR 1020127025613A KR 20127025613 A KR20127025613 A KR 20127025613A KR 20130018407 A KR20130018407 A KR 20130018407A
Authority
KR
South Korea
Prior art keywords
peptide
construct
composition
vaccine
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020127025613A
Other languages
English (en)
Korean (ko)
Inventor
페테르 울리히
카차 바에르
조르쥬 엥베르
마리-호세 올링거
마리-엠마뉴엘 리비에르
안나 그라프
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42285305&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20130018407(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20130018407A publication Critical patent/KR20130018407A/ko
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0007Nervous system antigens; Prions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6075Viral proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
KR1020127025613A 2010-03-29 2011-03-28 바이러스-유사 입자에 커플링된 아밀로이드 베타 1-6 펩티드 및 아주반트를 포함하는 조성물 Ceased KR20130018407A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10158273.2 2010-03-29
EP10158273 2010-03-29
US36169710P 2010-07-06 2010-07-06
US61/361,697 2010-07-06
PCT/EP2011/054735 WO2011120924A1 (en) 2010-03-29 2011-03-28 Composition comprising the amyloid beta 1-6 peptide coupled to a virus-like particle and an adjuvant

Publications (1)

Publication Number Publication Date
KR20130018407A true KR20130018407A (ko) 2013-02-21

Family

ID=42285305

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127025613A Ceased KR20130018407A (ko) 2010-03-29 2011-03-28 바이러스-유사 입자에 커플링된 아밀로이드 베타 1-6 펩티드 및 아주반트를 포함하는 조성물

Country Status (24)

Country Link
US (4) US20130011431A1 (enExample)
EP (1) EP2552489A1 (enExample)
JP (2) JP6088422B2 (enExample)
KR (1) KR20130018407A (enExample)
CN (2) CN102834118A (enExample)
AR (1) AR080810A1 (enExample)
AU (1) AU2011234656B2 (enExample)
BR (1) BR112012024708A2 (enExample)
CA (1) CA2793580A1 (enExample)
CL (1) CL2012002685A1 (enExample)
CO (1) CO6630127A2 (enExample)
EC (1) ECSP12012180A (enExample)
GT (1) GT201200265A (enExample)
IL (1) IL221540B (enExample)
MA (1) MA34084B1 (enExample)
MX (1) MX2012011340A (enExample)
NZ (1) NZ601729A (enExample)
PE (1) PE20130642A1 (enExample)
PH (1) PH12012501683A1 (enExample)
RU (1) RU2603486C2 (enExample)
SG (2) SG183806A1 (enExample)
TN (1) TN2012000431A1 (enExample)
TW (2) TW201618806A (enExample)
WO (1) WO2011120924A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3027205A4 (en) 2013-07-28 2017-07-19 Qantu Therapeutics, Inc. Vaccine formulations that induce a th2 immune response
ES2651537T3 (es) * 2014-04-29 2018-01-29 Affiris Ag Tratamiento y prevención de la enfermedad de Alzheimer (AD)
WO2015165961A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
WO2015165971A1 (en) * 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
CN106659736A (zh) 2014-04-29 2017-05-10 阿费里斯股份公司 阿尔茨海默病(ad)的治疗和预防
EP3137097B1 (en) * 2014-04-29 2023-06-21 ADvantage Therapeutics, Inc. Treatment and prevention of alzheimer's disease (ad)
ES2571055B1 (es) * 2016-02-15 2016-12-28 Araclon Biotech, S.L. Conjugado amiloide y usos y procedimientos del mismo
CA3150482A1 (en) 2019-09-16 2021-03-25 Amgen Inc. Method for external sterilization of drug delivery device

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201906B (en) 1987-03-04 1991-01-28 Sandoz Ag Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them
US6153201A (en) * 1993-03-09 2000-11-28 University Of Rochester Oral immunization with papillomavirus virus-like particles
FR2734484B1 (fr) * 1995-05-24 1997-06-27 Pasteur Merieux Serums Vacc Composition vaccinale liquide et procede de fabrication
CA2295740A1 (en) * 1997-07-08 1999-01-21 Chiron Corporation Use of submicron oil-in-water emulsions with dna vaccines
AU2002330681C1 (en) * 2001-07-26 2015-04-02 Glaxosmithkline Biologicals S.A. Vaccines comprising aluminium adjuvants and histidine
DK1524994T3 (da) * 2002-07-19 2011-08-15 Cytos Biotechnology Ag Vaccinesammensætninger indeholdende amyloid beta 1-6-antigen-arrays
CN100409896C (zh) * 2003-03-31 2008-08-13 姚志彬 一种老年性痴呆疫苗及其制备方法
MX2007003171A (es) * 2004-09-21 2007-05-23 Cytos Biotechnology Ag Particulas tipo virus que comprenden una proteina de fusion de la proteina de cubierta de ap205 y un polipeptido antigenico.
GB0424563D0 (en) * 2004-11-05 2004-12-08 Novartis Ag Organic compounds
CN101318015A (zh) * 2008-06-25 2008-12-10 中山大学 老年性痴呆重组蛋白疫苗及其制备方法

Also Published As

Publication number Publication date
PH12012501683A1 (en) 2012-11-05
NZ601729A (en) 2013-10-25
AR080810A1 (es) 2012-05-09
SG183806A1 (en) 2012-10-30
MX2012011340A (es) 2012-11-16
TW201138805A (en) 2011-11-16
AU2011234656B2 (en) 2013-08-01
CN102834118A (zh) 2012-12-19
JP6088422B2 (ja) 2017-03-01
CO6630127A2 (es) 2013-03-01
JP2017008035A (ja) 2017-01-12
US20150297692A1 (en) 2015-10-22
ECSP12012180A (es) 2012-10-30
RU2603486C2 (ru) 2016-11-27
GT201200265A (es) 2014-03-14
US20140348871A1 (en) 2014-11-27
CN104436212A (zh) 2015-03-25
BR112012024708A2 (pt) 2016-06-07
US20160101167A1 (en) 2016-04-14
PE20130642A1 (es) 2013-06-19
RU2012145734A (ru) 2014-05-10
SG10201505374TA (en) 2015-08-28
US20130011431A1 (en) 2013-01-10
MA34084B1 (fr) 2013-03-05
EP2552489A1 (en) 2013-02-06
WO2011120924A1 (en) 2011-10-06
TN2012000431A1 (en) 2014-01-30
IL221540B (en) 2018-11-29
JP2013523682A (ja) 2013-06-17
CA2793580A1 (en) 2011-10-06
AU2011234656A1 (en) 2012-10-11
CL2012002685A1 (es) 2013-01-25
TW201618806A (zh) 2016-06-01

Similar Documents

Publication Publication Date Title
JP6088422B2 (ja) ウイルス様粒子に結合しているアミロイドベータ1−6ペプチドおよびアジュバントを含む組成物
US20090123488A1 (en) Compositions and methods for the treatment and prophylaxis of Alzheimer's disease
WO2013020724A1 (en) Composition comprising a tlr agonist and an antibody specific for an antigen and uses thereof as vaccine
TW202221017A (zh) 治療阿茲海默氏症之多表位疫苗
JP2023541669A (ja) アルツハイマー病の処置のためのβ-アミロイドワクチン
KR20230087499A (ko) 알츠하이머 질환 치료용 멀티에피토프 백신
US8617566B2 (en) Composition comprising VLP and amyloid beta peptide
AU2013221980A1 (en) Composition comprising the amyloid beta 1-6 peptide coupled to a virus-like particle and an adjuvant
AU2011253800B2 (en) Composition comprising VLP and amyloid-beta peptide
KR20240082368A (ko) 타우 포스포펩티드 접합체의 안전한 투여 방법
HK1150961A (en) Composition comprising vlp and amyloid-beta peptide

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20120928

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20160328

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20170523

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20171226

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20170523

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I