KR20120101339A - 과분극 물질 및 그 혼합물의 제조용 시스템 및 제조방법 - Google Patents

과분극 물질 및 그 혼합물의 제조용 시스템 및 제조방법 Download PDF

Info

Publication number
KR20120101339A
KR20120101339A KR1020127008209A KR20127008209A KR20120101339A KR 20120101339 A KR20120101339 A KR 20120101339A KR 1020127008209 A KR1020127008209 A KR 1020127008209A KR 20127008209 A KR20127008209 A KR 20127008209A KR 20120101339 A KR20120101339 A KR 20120101339A
Authority
KR
South Korea
Prior art keywords
polarization
temperature
nucleus
magnetic field
hyperpolarized
Prior art date
Application number
KR1020127008209A
Other languages
English (en)
Korean (ko)
Inventor
닐 칼레초프스키
아브럼 벨저
Original Assignee
밀리켈빈 테크놀로지스 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 밀리켈빈 테크놀로지스 엘엘씨 filed Critical 밀리켈빈 테크놀로지스 엘엘씨
Publication of KR20120101339A publication Critical patent/KR20120101339A/ko

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020127008209A 2009-08-31 2010-08-31 과분극 물질 및 그 혼합물의 제조용 시스템 및 제조방법 KR20120101339A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23864709P 2009-08-31 2009-08-31
US61/238,647 2009-08-31

Publications (1)

Publication Number Publication Date
KR20120101339A true KR20120101339A (ko) 2012-09-13

Family

ID=43628703

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127008209A KR20120101339A (ko) 2009-08-31 2010-08-31 과분극 물질 및 그 혼합물의 제조용 시스템 및 제조방법

Country Status (9)

Country Link
EP (1) EP2473198A4 (ja)
JP (1) JP5792726B2 (ja)
KR (1) KR20120101339A (ja)
CN (1) CN102753201A (ja)
AU (1) AU2010286413B2 (ja)
CA (1) CA2772190A1 (ja)
IN (1) IN2012DN02418A (ja)
SG (1) SG178927A1 (ja)
WO (1) WO2011026103A2 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101321862B1 (ko) 2006-02-21 2013-10-28 밀리켈빈 테크놀로지스 엘엘씨 과분극화 방법, 시스템 및 조성물
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
US5809801A (en) * 1996-03-29 1998-09-22 The Trustees Of Princeton University Cryogenic accumulator for spin-polarized xenon-129
US6426058B1 (en) 1996-03-29 2002-07-30 The Regents Of The University Of California Enhancement of NMR and MRI in the presence of hyperpolarized noble gases
CN1224502A (zh) * 1996-03-29 1999-07-28 劳伦斯·伯克利国家实验室 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高
GB9614139D0 (en) 1996-07-05 1996-09-04 Nycomed Imaging As Method
EP0951650B1 (en) * 1997-01-08 2003-12-10 Amersham Health AS Method of magnetic resonance imaging
EP0990168A1 (en) * 1997-06-19 2000-04-05 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
EP1047455B1 (en) 1997-11-12 2008-08-20 GE Healthcare AS Para-hydrogen labelled agents and their use in non-proton magnetic resonance imaging
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB0001727D0 (en) 2000-01-25 2000-03-15 Oxford Instr Uk Ltd Hyperpolarization of a noble gas
BR0115124B1 (pt) 2000-11-03 2012-12-25 dispositivo para fundir uma amostra hiperpolarizada sàlida, mÉtodo para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo ou mÉtodo.
HUP0302425A3 (en) * 2000-11-03 2011-04-28 Ge Healthcare As Methods and devices for polarised nmr samples
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
DE102004002639A1 (de) * 2004-01-19 2005-09-15 Forschungszentrum Jülich GmbH Verfahren zur Anreicherung von hyperpolarisierten Atomkernen und Vorrichtung zur Durchführung des Verfahrens
GB0501346D0 (en) * 2005-01-21 2005-03-02 Oxford Instr Molecular Biotool Method of carrying out dynamic nuclear polarization
FR2881226B1 (fr) * 2005-01-27 2007-04-27 Commissariat Energie Atomique Accroissement de la polarisation des spins nucleaires d'une molecule via un transfert de polarisation de type hartmann-hahn utilisant le champ dipolaire moyen cree par une source
GB0514303D0 (en) * 2005-07-12 2005-08-17 Oxford Instr Molecular Biotool Magnet assembly
KR101321862B1 (ko) * 2006-02-21 2013-10-28 밀리켈빈 테크놀로지스 엘엘씨 과분극화 방법, 시스템 및 조성물
NL2000122C2 (nl) * 2006-07-03 2008-01-07 Vialle Alternative Fuel System Bufferhouder.
US7631507B2 (en) * 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance

Also Published As

Publication number Publication date
IN2012DN02418A (ja) 2015-08-21
CA2772190A1 (en) 2011-03-03
JP5792726B2 (ja) 2015-10-14
JP2013503021A (ja) 2013-01-31
CN102753201A (zh) 2012-10-24
EP2473198A4 (en) 2015-06-24
SG178927A1 (en) 2012-04-27
AU2010286413B2 (en) 2014-11-20
WO2011026103A2 (en) 2011-03-03
EP2473198A2 (en) 2012-07-11
WO2011026103A3 (en) 2011-07-21
AU2010286413A1 (en) 2012-04-05

Similar Documents

Publication Publication Date Title
US8703102B2 (en) Systems and methods for producing hyperpolarized materials and mixtures thereof
Eills et al. Spin hyperpolarization in modern magnetic resonance
Barskiy et al. NMR hyperpolarization techniques of gases
Ardenkjaer-Larsen On the present and future of dissolution-DNP
CA2643306C (en) Hyperpolarization methods, systems and compositions
US20140223923A1 (en) Systems and methods for producing hyperpolarized materials and mixtures thereof
US6125654A (en) Bulk production and usage of hyperpolarized 129 Xenon
KR20120101339A (ko) 과분극 물질 및 그 혼합물의 제조용 시스템 및 제조방법
US20110050228A1 (en) agent for transporting nuclear spin order and for magnetic resonance imaging
Krjukov et al. Brute force polarization of 129 Xe
Berthault et al. Use of dissolved hyperpolarized species in NMR: Practical considerations
JP4420224B2 (ja) 過分極１２９Ｘｅの製造法
EP2917749B1 (en) Method of hyperpolarization applying brute force using particulate acceleration agents
CA2720333C (en) Manufacture, transport and delivery of material containing highly polarized nuclei
Goodson et al. The Physics of Hyperpolarized Gas MRI
AU2013205838B2 (en) Hyperpolarization Methods, Systems and Compositions
van den Brandt et al. Dynamic nuclear polarization–from polarized targets to metabolic imaging
Charlaftis Dynamic Nuclear Polarization of Beta-Cyclodextrin Derivatives
O'Neill Brute force polarisation of xenon-129
Milani Novel Instrumentation and Methods for Chemical Applications of Dissolution Dynamic Nuclear Polarization
Goodson et al. NMR and MRI of laser-polarized noble gases in molecules, materials, and medicine
AU2016204108A1 (en) Hyperpolarization Methods, Systems and Compositions
Nikolaou Spectroscopic studies of nuclear spins polarized via spin exchange optical pumping and dynamic coupling in cryptophane host-guest complexes

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application