KR20120080226A - 스테아로일-ｃｏａ 탈포화화효소를 조절하는 피라졸 유도체 - Google Patents

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Publication number

KR20120080226A

KR20120080226A KR1020127011127A KR20127011127A KR20120080226A KR 20120080226 A KR20120080226 A KR 20120080226A KR 1020127011127 A KR1020127011127 A KR 1020127011127A KR 20127011127 A KR20127011127 A KR 20127011127A KR 20120080226 A KR20120080226 A KR 20120080226A

Authority

KR

South Korea

Prior art keywords

alkyl

optionally substituted

aryl

cycloalkyl

heteroaryl

Prior art date

2009-10-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

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• 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 43
• 230000000694 effects Effects 0.000 claims abstract description 40
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• 150000001875 compounds Chemical class 0.000 claims description 236
• -1 quinolin-4-ylmethyl Chemical group 0.000 claims description 188
• 125000003118 aryl group Chemical group 0.000 claims description 160
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 140
• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 133
• 125000001072 heteroaryl group Chemical group 0.000 claims description 130
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• 125000000217 alkyl group Chemical group 0.000 claims description 97
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• 150000002431 hydrogen Chemical class 0.000 claims description 65
• 150000003839 salts Chemical class 0.000 claims description 47
• 125000006690 (C2-C6) heterocyclyl group Chemical group 0.000 claims description 46
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• 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 41
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• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 32
• 230000001404 mediated effect Effects 0.000 claims description 31
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 28
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 27
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 27
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• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 16
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• GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims description 15
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• FKNRJGRCVHFLQP-UHFFFAOYSA-N n-[(3,4-difluorophenyl)methyl]-3-[1-[(4-fluorophenyl)methyl]-5-oxo-1,2,4-triazol-4-yl]-1h-pyrazole-5-carboxamide Chemical compound C1=CC(F)=CC=C1CN1C(=O)N(C2=NNC(=C2)C(=O)NCC=2C=C(F)C(F)=CC=2)C=N1 FKNRJGRCVHFLQP-UHFFFAOYSA-N 0.000 claims description 4
• 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 4
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