KR20120037145A - Composition for preventing or treating obesity or hyperlipidemia containing piper longum extract, isoflavon and l-carnitin - Google Patents

Abstract

PURPOSE: A composition containisng Piper longum L. extract, isoflavone, and L-carnitine is provided to reduce body fat and body weight and to enhance energy consumption. CONSTITUTION: A composition for preventing or treating obesity contains 0.0001-10 wt% of Piper longum L. extract, 0.0001-10 wt% of isoflavone, and 0.001-40 wt% of L-carnitine as an active ingredient. The composition is used for suppressing neutral fat. A composition for treating or preventing hyperlipidemia contains the Piper longum L. extract, isoflavone, and L-carnitine as an active ingredient.

Description

Composition for preventing or treating obesity or hyperlipidemia containing Piper longum extract, isoflavon and L-carnitin}

The present invention relates to a composition for preventing or improving obesity or hyperlipidemia, more specifically, by containing simultaneously extract, isoflavone and L-carnitine as an active ingredient to reduce body fat and weight and increase activity The present invention relates to a composition for preventing or improving obesity or hyperlipidemia, which provides a heat generation promoting effect of increasing energy consumption without.

Changes in weight occur by the difference between total energy intake and consumption, so to lose weight you need to reduce your energy intake or increase your energy consumption. The body's energy consumption can be divided into several components, including the main components of rest and activity. Total daily energy expenditure (TEE) consists of resting metabolic rate (RMR), thermic effect of food (TEF), and energy expenditure from physical activity. It is.

Among these, "food heat generation" refers to the energy consumption increased by basal metablic rate (BMR) due to food intake, cold exposure, heatogenic agents and psychological effects. It is a way to consume energy without consuming, ie without exercise. The organelles responsible for this heat generation in the body are mitochondria, where nutrients are produced as heat instead of ATP by uncoupling oxidative phosphorylation. The protein involved in this heat-generating reaction is the uncoupling protein (UCP), and inducing or increasing the expression of UCP leads to increased heat production and weight loss (Nedergaard J., et al., EMBO Rep. 6: 917-921, 2005). In addition, weight gain in most obese patients after discontinuing low calorie diets can be described as a thermogenic defect. Heat-generating defects can save up to 125 kcal of energy per day. The energy consumption of less than 25 kcal / day per kilogram of increased body weight increases, which can explain the weight gain of 5 kg due to the effect of heat generation defects.

Recently, inhibitors of the cannabioid type I (CB1) receptor have been reported to promote the conversion of white fat to brown fat and increase the heat production response (Perwitz N., et al., Diabetes, Obesity and Metabolism, 12: 158). -166, 2010). However, since people avoid cold exposure through clothing or room temperature control, energy consumption effects through promoting heat generation mechanisms alone in daily life are not significant.

On the other hand, hyperlipidemia is a condition in which more fat components are present in the blood and accumulated in the blood vessel walls, causing inflammation and consequently causing cardiovascular diseases. Recently, abnormal lipid states in the blood have been defined as dyslipidemia. In some cases, hyperlipidemia may occur due to an increase in specific lipids in the blood due to genetic factors, but hyperlipidemia may also be caused by other causes such as obesity, alcohol, and diabetes.

Accordingly, the present inventors have confirmed that the simultaneous treatment of the essential extract, isoflavone, and L-carnitine provides a heat generation promoting effect of reducing body fat and weight and increasing energy consumption without increasing the amount of activity, thereby completing the present invention. Was done.

Accordingly, it is an object of the present invention to provide a composition for preventing or improving obesity, which can feel heat loss, weight loss and immediate cognitive efficacy.

It is also an object of the present invention to provide a composition for treating or preventing hyperlipidemia that lowers the content of triglycerides or cholesterol in the blood.

In order to achieve the above object, the present invention provides a composition for preventing or improving obesity containing the essential extract, isoflavone and L-carnitine as an active ingredient.

In another aspect, the present invention provides a composition for the treatment or prevention of hyperlipidemia containing an essential extract, isoflavones and L-carnitine as an active ingredient.

The composition according to the present invention contains essential extracts, isoflavones and L-carnitine as active ingredients, thereby reducing the body fat and weight and promoting heat generation to increase energy consumption without increasing the amount of activity, thereby treating obesity or the like. It was confirmed that it is effective for prevention. In addition, the composition according to the present invention was effective in treating or preventing hyperlipidemia by significantly reducing the content of triglycerides and cholesterol in the blood.

Therefore, the composition according to the present invention can be used in various fields such as food and medicine for the prevention or treatment of obesity and hyperlipidemia.

1 and 2 are graphs confirming the weight loss effect of test substances in male C57BL / 6 mice induced obesity by a high fat diet.
Figure 3 is a graph confirming the effect of weight loss of epididymal fat of test substances in male C57BL / 6 mice induced obesity by high fat diet.
Figure 4 is a graph confirming the effect of enhancing the expression of heat generation protein (UCP1) in male C57BL / 6 mice induced obesity by high fat diet.

The present invention relates to a composition for preventing or improving obesity containing an essential extract, isoflavone and L-carnitine as an active ingredient, and due to the synergistic effects of the respective active ingredients, more body fat and weight loss effects than when treated alone. It provides a composition for preventing and improving obesity showing. In addition, the composition according to the present invention can treat or prevent hyperlipidemia by lowering the content of cholesterol and triglycerides in the blood.

: Piper longum L.)은 필발(

)에서 유래되었으며, 생김새는 원주형으로 과축(果軸)의 주위에는 작은 알맹이의 열매가 무수히 붙어 있어 그물눈 모양을 나타내고, 바깥면은 적갈색이나 흑갈색이다. 열매의 위쪽에 셋으로 갈라진 주두(柱頭)가 있고 아래쪽은 과축이 붙어 있다.Unavoidable

: Piper longum L.)

) The shape is columnar, and the fruit of the small kernel is attached to the periphery of myriads. It has a mesh shape, and the outer surface is reddish brown or blackish brown. The upper part of the fruit is divided into three, and the lower part is attached to the fruit axis.

The extract extract used in the present invention may be prepared by separating and purifying the extract from hot water based on a conventional herbal medicine extraction method, and in one embodiment of the present invention, after distilled water is pulverized, 10 times compared to the content of the extract Extracting in a shaker for about 3 hours; And after filtering the filtrate obtained in the extraction step, and freeze-dried through a step of evaporating to concentrate the prepared extract, but is not limited thereto. In the present invention, it was confirmed that the essential extract has a heat generation promoting effect of increasing the energy consumption without increasing the amount of activity by promoting the expression of heat generating mechanism-related protein UCP1.

The composition according to the present invention may contain the 0.001 to 10% by weight of the essential extract, and when the content of the essential extract is less than 0.0001% by weight, the effect of promoting heat generation is insignificant, and exceeds 10% by weight. Formulation stability may be reduced.

Isoflavones used in the present invention have been reported to exhibit various physiological activities as plant hormones similar to female hormones, which are contained in soybeans, and various studies such as fat metabolism control in fat cells and reduction of blood cholesterol Results have been reported. In the present invention, the isoflavone itself may be used, or soybean extract containing isoflavone may be used. The soybean extract can be used by commercially available or prepared through extraction methods commonly known in the art.

The composition according to the present invention may contain isoflavones in an amount of 0.0001 to 10% by weight based on the total weight of the composition, and when using a soybean extract containing isoflavones, 0.001 to 30% by weight relative to the total weight of the composition May contain soy extract. If the content of the isoflavone or soybean extract is less than the appropriate range, the body fat and weight loss effect is insignificant, and if it exceeds the appropriate range, the formulation stability may be reduced.

L-carnitine used in the present invention is a component synthesized in the liver or kidney of a normal person and contained in a lot of red meat, and is known as an important component for oxidizing fat to generate energy. Deficiency of L-carnitine reduces the concentration of fatty acids in the mitochondria, thereby reducing energy production. In addition, CPT-1, which uses L-carnitine as a substrate, acts as a rate limiting enzyme for fatty acid oxidation among various enzymes involved in fatty acid oxidation (Eaton, Prog Lipid Res 41 (3): 197-269, 2002).

The composition according to the present invention may contain L-carnitine in an amount of 0.001 to 40% by weight based on the total weight of the composition, when the content is less than 0.001% by weight, the effects of body fat and weight loss are insignificant, and more than 40% by weight. Formulation stability may be reduced.

Setting the content range of the active ingredient can be said to reflect the characteristics of each component in terms of safety as well as bring about a synergistic effect on the efficacy of the human body when commercialized. In addition, the maximum weight range was limited in consideration of the molding conditions of the active ingredient suitable for the formulation of the product.

The composition according to the present invention can be applied in the form of oral medicines and foods, and has the effect of promoting energy consumption by lowering body fat and increasing the expression of UCP1, which is a major biomarker involved in the heat production mechanism. . This is because the composition of the present invention simultaneously contains isoflavones, L-carnitine, and essential extracts, thereby promoting and sustaining the mechanisms of lipolysis, fat burning, and heat generation through different mechanisms in adipocytes, and actively supporting them. This provided more weight loss compared to treatment with isoflavones and L-carnitine alone. In addition, by significantly reducing the content of triglycerides and cholesterol in the blood provided a hyperlipidemia treatment or prevention effect.

The composition of the present invention is appropriately selected in addition to the above-mentioned ingredients in the art, and then tablets, capsules, soft capsules, pills, granules, drinks, diet bars, chocolate, caramel formulations and confectionery, etc. It can be formulated and used as a health food or medicine.

Hereinafter, the present invention will be described more specifically with reference to examples and test examples. These examples are provided only for understanding the contents of the present invention, and the scope of the present invention is not limited to these examples, and modifications, substitutions, and insertions commonly known in the art may be performed. This is also included in the scope of the present invention.

Preparation Example 1 Preparation of Essential Extract

In the present invention, a Chinese shot is used. After pulverizing the hairs, distilled water was added 10 times compared to the hairs content, and the filtrate obtained by extracting in a shaker for about 3 hours was filtered, freeze-dried and concentrated by evaporation to obtain hairs extract.

Example 1

The composite of Example 1 was prepared by mixing the essential extract, soybean extract (isoflavone content: 10.76% by weight) and L-carnitine in a weight ratio of 1: 0.75: 1 prepared in Preparation Example 1.

Test 1 Weight loss effect in male C57BL / 6 mice

In order to proceed with the experiment, 10 animals per group were prepared for 7-week-old C57BL / 6J male mice, and after 1 week of adaptation, they were separated into individual cages for 12 hours of daytime (7 ~ 17 hours) and night. Managed according to the cycle. Each experimental group was 1) "normal diet group", 2) "high fat diet group (control)", 3) "high diet + isoflavone + L-carnitine (350 mpk) intake group", 4) "high diet + iso Flavone + L-carnitine (350mpk) + essential extract (200mpk) intake group ", 5)" high fat diet + isoflavones + L-carnitine (350mpk) + chacatechin (200mpk) intake group ", and 6)" high fat diet The group was divided into six groups, including the group of 2+ intake extracts (200mpk), and orally administered once a day for 8 weeks at a certain time (10 am), and 10 animals of the high-fat diet group, the control group, received the same amount of water. Administered. Chacatechin contains more than 80% of catechins and has been widely known to have anti-obesity effects by reducing body fat (Thielecke F., et. al ., Phytochemistry, 70: 11-24, 2009). Chacatechin was added to the complex of isoflavone and L-carnitine to verify the synergistic effect. At this time, the total calories of the high-fat diet and the normal diet is equal to 4,057 kcal, but in the high-fat diet, fat accounts for 60% of the total calories, and normal diet occupies 10%.

ingredient High Fat Diet (1) (g / kg) Normal diet (2) (g / kg) Casein 200 200 Corn Powder 0 315 Maltodextrin 125 35 Sucrose 68.8 350 cellulose 50 50 Soybean oil 25 25 Lard 245 20 Mineral mix 10 10 Calcium phosphate 13 13 Calcium carbonate 5.5 5.5 Potassium citrate 16.5 16.5 Vitamin Mix (see Table 8) 10 10

1) syntheric diet D12494 (Research Diets, Inc)

2) syntheric diet D12450B (Research Diets, Inc)

Body weight was measured once a week (11 AM) during the experimental period, the weight change was calculated by measuring the final weight of the experimental group and the control group 8 weeks after the start of the administration, the results are shown in Table 2, Figures 1 and 2 Indicated.

Test substance Body weight before experiment (g) Body weight after experiment (g) % Change in weight Normal diet group (n = 10) 18.78 ± 0.82 26.3 ± 1.78 40.4% High fat diet group (n = 10) 20.28 ± 0.62 34.1 ± 2.16 68.5% High Fat Diet + Isoflavones + L-Carnitine (n = 10) 20.63 ± 1.05 34.0 ± 3.3 64.9% High Fat Diet + Isoflavones + L-Carnitine + Essential Extract (n = 10) 19.03 ± 0.54 27.1 ± 1.63 42.5% * High Fat Diet + Isoflavones + L-Carnitine + Chacatechin (n = 10) 20.23 ± 0.85 34.4 ± 3.41 69.7% High fat diet + essential extract (n = 10) 19.98 ± 0.87 33.9 ± 2.45 69.7%

* p <0.05

Figure 1 shows the change in body weight over time for each population, Figure 2 shows the increase in weight. In the results of Table 2, FIGS. 1 and 2, "high fat diet + isoflavone + L-carnitine intake group", "high fat diet + isoflavone + L-carnitine + tea catechin intake group" and "high fat diet + dementia" Extract intake group "was not confirmed a special weight loss effect compared to the control group fed only high fat diet. On the other hand, in the "high fat diet + isoflavone + L- carnitine + incidence extract intake group", after 8 weeks, the weight change was about 42.5%, it was confirmed that the weight gain inhibitory effect than the high fat diet group (p <0.05).

Therefore, the complex of isoflavone + L-carnitine and the extract extract according to the present invention was confirmed to have an excellent effect of inhibiting weight gain statistically compared to the complex of isoflavone / L-carnitine. However, only the extract extract was confirmed that there is no effect of inhibiting weight gain. There was no significant difference in dietary intake between the experimental groups.

Test Example 2 Evaluation of Adipose Tissue in Male C57BL / 6 Mice

In order to investigate the effect of the composition of the present invention on fat reduction of obese animals induced by high fat diet, "normal diet group", "high fat diet group (control)", "high fat diet group + iso" at the same concentration as Test Example 1 Flavone + L-carnitine intake group "," high fat diet + isoflavone + L-carnitine + essential extract intake group "," high fat diet + isoflavone + L-carnitine + tea catechin intake group "and" high fat diet + Six groups of the "primary extract intake group" were consumed for 8 weeks. Liver and epididymal fats were extracted at the end of the diet. The extracted tissues were washed with physiological saline and then lightly removed from the filter paper and weighed. The results are shown in Table 3 and FIG. 3, respectively.

Test substance Liver (g / body weight g) Epididymal fat
(g / body weight g) Normal diet group (n = 10) 47.15 ± 2.43 24.39 ± 5.36 High fat diet group (n = 10) 31.1 ± 1.99 ^a 62.6 ± 9.65 ^a High Fat Diet + Isoflavones + L-Carnitine (n = 10) 31.7 ± 2.83 54.8 ± 14.84 High Fat Diet + Isoflavones + L-Carnitine + Essential Extract (n = 10) 32.3 ± 1.83 39.8 ± 5.53 ^b High Fat Diet + Isoflavones + L-Carnitine + Chacatechin (n = 10) 31.8 ± 2.56 61.1 ± 11.96 High fat diet + essential extract (n = 10) 31.9 ± 4.56 63.3 ± 9.56

^a p <0.05 vs normal diet, ^b p <0.05 high fat diet

In the results of Table 3, the weight of the epididymal adipose tissue of each population was calculated as a result of weight comparison, "high fat diet group" is 62.6 ± 9.65 g, "high fat diet + isoflavone + L- carnitine intake group" 54.8 ± 14.84 g, "high fat diet + isoflavone + L-carnitine + tea catechin intake group" was 61.1 ± 11.96 g, and "high fat diet + essential extract intake group" was 63.3 ± 9.56, while "high fat diet + iso Flavone + L-carnitine + incidence complex intake group "was 39.8 ± 5.53 g.

In addition, in the "high fat diet + isoflavone + L-carnitine + incidence extract intake group", "high fat diet + isoflavone + L-carnitine intake group" or "high fat diet + isoflavone + L-carnitine + tea catechin intake" Compared with the group ", the weight of the epididymal adipose tissue was significantly reduced. Through this, it can be seen that the composite extract of isoflavone, L-carnitine and essential extract according to the present invention has a synergistic effect on body fat reduction.

Test Example 3 Evaluation of Blood Biochemical Components Efficacy in Male C57BL / 6 Mice

In order to investigate the effect of the composition of the present invention on blood fat metabolism-related indicators of obese animals induced by a high fat diet, the same concentration as in Test Example 1, "normal diet group", "high fat diet group (control)", "high fat diet 2 group + isoflavone + L-carnitine intake group "," high-fat diet + isoflavone + L-carnitine + incidence extract intake group "," high-fat diet + isoflavone + L-carnitine + chacatechin intake group "and" Notice " Six groups of the dietary group + the essential extract intake group "were taken for 8 weeks. At the end of the experiment, sacrifice was performed to collect 1 ml of blood by orbital sampling. After centrifugation at 3,000 rpm for 30 minutes, the supernatant (serum) was separated and blood glucose (glucose in serum), total cholesterol (HDL) amount, HDL using an automatic blood analyzer (H1 system, Technicon, USA) , LDL and triglyceride were analyzed, and the results are shown in Table 4 below.

Test substance Blood sugar
(mg / dL) Total cholesterol
(mg / dL) HDL
(mg / dL) LDL
(mg / dL) Triglyceride
(mg / dL) Normal diet group (n = 10) 234.4 ± 8.49 110.4 ± 11.58 93.5 ± 0.09 18.8 ± 0.12 78.3 ± 6.97 High fat diet group (n = 10) 270.0 ± 0.77 ^a 159.5 ± 9.09 ^a 125.5 ± 4.05 ^a 29.5 ± 3.51 ^a 97.4 ± 8.48 ^a High Fat Diet + Isoflavones + L-Carnitine (n = 10) 236.4 ± 36.88 158.5 ± 12.76 126.0 ± 6.04 28.6 ± 4.54 76.4 ± 12.25 ^b High Fat Diet + Isoflavones + L-Carnitine + Essential Extract (n = 10) 213.1 ± 17.22 ^b 140.4 ± 9.3 ^b 119.9 ± 6.55 25.9 ± 1.96 ^b 69.9 ± 8.80 ^b High Fat Diet + Isoflavones + L-Carnitine + Chacatechin (n = 10) 241.3 ± 32.46 165.1 ± 10.64 136.0 ± 24.91 32.4 ± 4.60 104.9 ± 33.63 High fat diet + essential extract (n = 10) 243.1 ± 17.34 166.2 ± 10.23 137.2 ± 18.23 30.4 ± 5.21 110.3 ± 25.43

^a p <0.05 vs normal diet, ^b p <0.05 high fat diet

In the results of Table 4, "high fat diet + isoflavone + L-carnitine intake group", "high fat diet + isoflavone + L-carnitine + tea catechin intake group" and "high fat diet + essential extract intake group" Was not significantly decreased in blood glucose and total cholesterol, especially LDL compared to the control (high fat diet group), but significantly decreased in the "high fat diet + isoflavone + L- carnitine + essential extract group". In triglycerides, the "high fat diet + isoflavone + L-carnitine intake group" significantly decreased compared to the control group, especially in the "high fat diet + isoflavone + L-carnitine + essential extract intake group". It was reduced by%, showing the best effect.

Test Example 4 Evaluation of UCP1 Expression of Heat Gene Related Protein in Male C57BL / 6 Mice

In order to investigate the effect of the composition of the present invention on the heat generation mechanism of obese animals induced by high fat diet, the same concentration as in Test Example 1, "normal diet group", "high diet group (control)", "high diet group + Isoflavone + L-carnitine intake group "," high fat diet + isoflavone + L-carnitine + essential extract intake group "," high fat diet + isoflavone + L-carnitine + chacatechin intake group "and" high fat diet group " 6 groups of the "integration extract intake group" for 8 weeks. After grinding the white adipose tissue of each experimental group, RNA was extracted using a trizol reagent (TRIzol agent, Invitrogen). CDNA was synthesized using 1 μg / μl of RNA extracted from the above and a reverse transcription system (Promega). Using pre-designed primers and probes (Applied biosystems; UCP1, NM_009463.2, PGC1-α, Mm00447181_m1, GAPDH and Mm99999915_q1) The expression pattern of each gene was measured. PCR reactions and analysis were performed using the Rotor-Gene 3000 system (Corbett Research, Sydney, Australia). 40 cycles of annealing for 15 seconds and expansion at 60 ° C. for 60 seconds were repeated. The results are shown in FIG.

In the results of Figure 4, "high fat diet + isoflavones + L-carnitine intake group", "high fat diet + isoflavones + L-carnitine + tea catechin intake group" and "high fat diet + essential extract intake group" There was no expression of UCP1, a heat-related protein. However, it was found that the expression of UCP1 was increased in the "high fat diet + isoflavone + L-carnitine + essential extract intake group". Accordingly, the present invention confirmed that the essential extracts give synergistic effects on the efficacy of isoflavones and L-carnitine.

Hereinafter, the composition of the isoflavone, L-carnitine and essential extract according to the present invention can be applied in various formulations as follows, but is not limited thereto.

Formulation Example 1 Preparation of Tablet

The tablets were prepared by mixing the ingredients described in Table 5 and then tableting according to a conventional manufacturing method.

ingredient content Composite of Example 1 50 mg Corn starch 100 mg Lactose 100 mg Magnesium Stearate 2 mg Vitamin c 50 mg

Formulation Example 2 Preparation of Capsule

According to a conventional capsule preparation method, the components shown in Table 6 were mixed and filled into gelatin capsules to prepare capsules.

ingredient content Composite of Example 1 50 mg Corn starch 100 mg Lactose 100 mg Magnesium Stearate 2 mg Vitamin c 50 mg Serine 50 mg

Formulation Example 3 Preparation of Liquid

According to the conventional liquid preparation method, the ingredients shown in Table 7 are added to the purified water to dissolve it, and then, lemon flavor is added, and then the above ingredients are mixed. Prepared.

ingredient content Composite of Example 1 100 mg Iseong Hwadang 10 g Mannitol 5 g Vitamin c 50 mg Serine 50 mg maintain Quantity Purified water Balance

Formulation Example 4 Preparation of Healthy Food

Although the composition ratio of the following vitamin and mineral mixtures is mixed with a component suitable for a health food in a preferred embodiment, the compounding ratio may be arbitrarily modified, and according to the conventional health food manufacturing method, After mixing, the granules are prepared and can be used for preparing the health food composition according to conventional methods.

ingredient content Composite of Example 1 1,000 mg Vitamin mixtures Vitamin A Acetate 70 μg Vitamin E 1.0 mg Vitamin B1 0.13 mg Vitamin B2 0.15 mg Vitamin B6 0.5 mg Vitamin B12 0.2 μg Vitamin c 10 mg Biotin 10 μg Nicotinic acid amide 1.7 mg Folic acid 50 μg Calcium Pantothenate 0.5 mg Mineral mixture Ferrous sulfate 1.75 mg Zinc oxide 0.82 mg Magnesium carbonate 25.3 mg Potassium phosphate monobasic 15 mg Dicalcium Phosphate 55 mg Potassium citrate 90 mg Calcium carbonate 100 mg Magnesium chloride 24.8 mg

Formulation Example 5 Preparation of Beverage

Following the conventional beverage preparation method, the ingredients shown in Table 9 were mixed and then stirred and heated at 85 ° C. for about 1 hour. The resulting solution was collected by filtration into a sterilized 2 l container, sealed sterilized, and then refrigerated and used for preparing the beverage composition of the present invention.

ingredient content Composite of Example 1 1 g Citric acid 1 g oligosaccharide 100 g Plum concentrate 2 g Taurine 1 g Purified water Balance

Formulation Example 6 Cream

Cream, as shown in Table 10, may be prepared according to a conventional method (unit: wt%).

ingredient content Composite of Example 1 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 0.5 PEG60 Cured Castor Oil 2.0 Liquid paraffin 10 Squalane 5.0 Caprylic / capric triglyceride 5.0 glycerin 5.0 Butylene glycol 3.0 Propylene glycol 3.0 Triethanolamine 0.2 antiseptic Quantity Pigment Quantity Spices Quantity Purified water Balance

Claims (8)

A composition for preventing or improving obesity, comprising an essential extract, isoflavone and L-carnitine as an active ingredient. The method of claim 1,
The essential extract is a composition for preventing or improving obesity that is contained in 0.0001 to 10% by weight relative to the total weight of the composition. The method of claim 1,
The isoflavone is contained in a 0.0001 to 10% by weight relative to the total weight of the composition for preventing or improving obesity. The method of claim 1,
The L-carnitine is a composition for preventing or improving obesity will be contained in 0.001 to 40% by weight relative to the total weight of the composition. The method according to any one of claims 1 to 4,
The composition is a composition for preventing or improving obesity which is a composition for promoting heat generation in the body. The method according to any one of claims 1 to 4,
The composition is an oral composition for preventing or improving obesity. The method according to any one of claims 1 to 4,
The composition is a composition for preventing or improving obesity is a composition for inhibiting triglycerides. A composition for the treatment or prevention of hyperlipidemia comprising an essential extract, isoflavone and L-carnitine as an active ingredient.

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