KR20110116017A - Powdery fat-containing soft capsules to be masticated - Google Patents

Abstract

The present invention relates to soft capsules widely used in "medicines", "specific health foods", "so-called health foods" and foods, and soft in gelatinous coatings while being soft in the mouth and having good chewability and solubility. The object is to provide a rich taste, to suppress the adhesion of the capsule film, the adhesion between the capsules and the container, and further to suppress the increase of the gelatin film moisture even under high humidity conditions. The low-action soft capsule of the present invention is characterized by being formed by blending powdered fats and oils with gelatin, plasticizer and water as a low-action soft capsule coating.

Description

Powder-fat blending low action soft capsule {POWDERY FAT-CONTAINING SOFT CAPSULES TO BE MASTICATED}

The present invention relates to soft capsules widely used in "medicines", "specific health foods", "so-called health foods" and foods, and is a low-action soft capsule formed by blending powdered fats and oils as a capsule coating. Related to.

The film moisture in the soft capsule containing the contents, such as a functional material, changes depending on the environment in which it is subjected, and under constant temperature conditions, it is governed by the relative humidity of the external air at that time (hereinafter simply referred to as "humidity"). The capsule moisture-proofs the coating moisture to the outside air or the moisture is absorbed from the outside air, and the amount of water reached by the outer air phase and the coating water in the capsule in equilibrium is reached (equilibrium moisture content).

Due to such changes in the film moisture of the capsule, changes in physical properties and physical and chemical properties occur, such as hardening, shrinkage, cracking, crystallization, and precipitation, leading to the flavor, aroma, color, and texture of the capsule. It is known to cause deterioration and the like. In addition, depending on the degree of increase in water content of the film, free water available to the microorganisms increases, and there is also a risk that a microbial problem occurs.

Therefore, suppressing the film moisture fluctuation of these capsules is a very important problem in quality maintenance.

As a means for solving this problem, the method of maintaining the equilibrium moisture content of a capsule by using the low moisture permeability, the sealing agent of a desiccant, the airtight container, etc. to suppress the influence of the humidity of a trauma to the minimum is used. (Non Patent Literature 1).

However, these methods have a problem that the water fluctuations are started when the capsule is placed in the open system or the cost thereof is not solved until now.

On the other hand, in the soft capsule containing a functional material etc., in the capsule coating which covers the content, it is common that plasticizers, such as glycerin and sorbitol, are mix | blended with gelatin coating in order to raise the strength, elasticity, etc.

However, if the blending ratio of the plasticizer is increased, the adhesiveness is inevitably imparted to the capsule, and particularly at high temperatures and high humidity, the adhesiveness is remarkable. Therefore, depending on the environmental conditions, the process of putting a soft capsule into a bottle, etc. The slipperiness of the capsules in the packaging process (slitteriness) is deteriorated, and these operations cannot be performed well, and the capsules adhere to each other or adhere to the capsule container even after the container is filled, so that the container can be easily removed from the container. I could not take it out.

On the other hand, when the compounding quantity of a plasticizer is made low, such adhesiveness can be suppressed, but mainly at low temperature and low humidity, since the elasticity of a capsule film part is insufficient and capsule strength falls, a film hardens | cures and it is called a crack and the leak of the content. There was a problem.

Therefore, although the compounding quantity of a plasticizer is moderately high, as various methods of suppressing adhesiveness, (1) addition of cellulose to a gelatin film (patent document 1), (2) hydrophobic substances, such as vegetable wax with respect to gelatin film, Addition (patent document 2), (3) Addition of crystalline water-soluble substances, such as xylitol, to a gelatin film (patent document 3), etc. are proposed.

However, although the method of the prior art has a certain effect on the prevention of adhesion, the formation of the capsule (adhesiveness of the capsule coating) is lowered, and a fresh taste peculiar to the gelatinous coating is left, chewability, solubility, taste It did not come to have sufficient commodity value from such a point.

In addition, depending on the degree of increase in the moisture of the soft capsule film, not only the anti-adhesion property is lowered, but also the number of free water available for use of microorganisms increases, which may cause microbial problems. As a solution for this, low-moisture-permeable materials, encapsulation of desiccants, airtight containers, and the like are used. However, in order to increase raw material costs and lower productivity, it is costly or, once the soft capsule is placed under high temperature and high humidity, the film moisture rises immediately. This starting problem is not resolved.

Moreover, in the drying process using the tumble dryer after the capsule shaping | molding using a rotary die type automatic soft capsule manufacturing machine, the method of making powder adhere to the capsule surface and improving adhesion prevention (patent document 4), etc. is also proposed, It was inferior and was not particularly suitable for producing small quantities of various varieties.

Japanese Unexamined Patent Publication No. 10-273436 Japanese Unexamined Patent Publication No. 2000-336028 Japanese Unexamined Patent Publication No. 2001-89362 Japanese Laid-Open Patent Publication 2001-178376

`` Basic and actual basis of Western confectionery manufacturing '' Gwangrim Pyeongsu, 3-year issue 303 ~ 372 pages

The present invention has been made in recognition of such a background. That is, the object of the present invention is to soften the gelatinous coating while having soft and good chewability and solubility in the oral cavity, and to give the gelatinous coating a soft taste, and excellent in adhesiveness of the capsule coating, prevention of adhesion between capsules and containers, Furthermore, it is providing the low action soft capsule which suppressed the raise of gelatin film water | moisture content even under high humidity conditions.

First, the low-action soft capsule of claim 1 is a soft capsule for drying the capsule film forming the capsule body after filling the film with the contents, wherein the film portion contains gelatin, plasticizer, powdered fat, water, It is characterized by being formed.

In addition, the low-action soft capsule of claim 2 has a compounding amount of 80 to 250 parts by weight based on 100 parts by weight of the gelatin, in addition to the requirements described in claim 1, wherein the oil or fat is powdered or powdered. The O / W emulsion containing the base material and the emulsifier is dried and powdered.

Moreover, the low action soft capsule of Claim 3 is 1-30 weight part with respect to 100 weight part of gelatin in addition to the requirement of the said Claim 1 or 2 in addition to the compounding quantity in the film of the said powder fats and oils.

In addition, the low-action soft capsule of claim 4 is a process of drying the low-action soft capsule film using a tumble dryer after filling the coating with the contents in addition to the requirements described in claim 1, 2 or 3 above. WHEREIN: The fats and oils derived from the powder fats and oils uniformly disperse | distributed to the capsule film are soaked in the capsule film surface, and the capsule surface is oil-coated with the fats and oils.

In the low-action soft capsule of claim 5, in addition to the requirements described in claim 1, 2, 3 or 4, the powdered base material which is a component of the powdered fat or oil is dextrin, maltodextrin, oligosaccharide, sucrose in the group consisting of It is characterized by being one type or a combination of two or more types selected.

Moreover, the low-action soft capsule of Claim 6 is an average particle diameter of 0.3-3 micrometers in addition to the requirement of Claim 1, 2, 3, 4 or 5 characterized by the above-mentioned.

The low-action soft capsule of claim 7, wherein the plasticizer is glycerin, sugar alcohol, propylene glycol, polyethylene glycol, monosaccharide, disaccharide, in addition to the requirements of claim 1, 2, 3, 4, 5 or 6. The oligosaccharide, isomaltooligosaccharide and polydextrose are selected from the group consisting of one or two or more kinds thereof.

In addition, the low-action soft capsule of claim 8, in addition to the requirements described in claim 1, 2, 3, 4, 5, 6 or 7, in the adjustment of the coating portion, gelatin, plasticizer, powder fat, water By containing it, it is characterized by improving adhesion prevention, chewability in mouth, solubility, and soft umami.

In addition, the low-action soft capsule of claim 9, in addition to the requirements described in claim 1, 2, 3, 4, 5, 6, 7 or 8, in adjusting the coating portion, gelatin, plasticizer, powder fat and oil And water, thereby suppressing the increase of the gelatinous film moisture.

In addition, the low-action soft capsule of claim 10, in addition to the requirements described in claim 1, 2, 3, 4, 5, 6, 7, 8 or 9, in adjusting the coating portion, gelatin, plasticizer, By containing powder oils and water, the rise of gelatinous film moisture is suppressed, and it is packed in a bottle without using a desiccant which is one type or a combination of two or more types selected from the group consisting of silica gel, calcium oxide, calcium chloride and silica alumina gel. Or packed into an envelope.

By blending powdered fats and oils as a low-action soft capsule film, the present inventors have a soft and pleasant chewability and solubility in the oral cavity, and give the gelatinous film a soft umami. It was found that the anti-adhesion property was excellent, and furthermore, the gelatinous film moisture was suppressed even under high humidity conditions.

By using the constitution of the invention described in each of these claims as a means, a low-acting soft capsule which does not require a desiccant such as silica gel when packed in a bottle or packed in a bag, and which maintains simpler and more stable quality. Can be obtained.

<Effect of adding powdered fat or oil as a low-action soft capsule film>

Although the effect of the powder fats and oils addition of this invention is not necessarily clear, it is inferred that the effect | action is performed by the physical property of powder fats and oils.

The powdered fats and oils used for this invention are dry food powders of O / W emulsion containing fats and oils, a powdered base material, and an emulsifier, and are the food materials which wrapped fats and oils with protein, sugar, etc. Therefore, the present inventors have found that there is a big difference between adding a powdered fat or oil as a capsule film and adding a conventional fat or oil as a capsule film.

That is, as a low-action soft capsule film, powder oils and fats are added to and disperse | distributed to the coating liquid which consists of gelatin, a plasticizer, and water, and it can be set as the oil droplet with an average particle diameter of about 1 micrometer. However, even if it adds fats and oils to gelatin coating liquid and stirs, it becomes fine only about 30-50 micrometers, and since fats and oils are hydrophobic substances, it is also very difficult to disperse | distribute uniformly to the coating liquid which consists of gelatin, a plasticizer, and water.

Although it differs also with fats and oils, it is assumed that an average particle diameter became fine about 30 micrometers by adding and stirring and disperse | distributing fats and oils to a gelatin film liquid. However, by adding powdered fats and oils to the gelatin coating liquid instead of fats and oils, if one oil droplet having a particle diameter of 30 mu m is decomposed into 27000 powder fats (303) having a particle diameter of 1 mu m, the surface area is 900 times ( 30 times ² ). When the surface area is increased, the function of emulsification stability is effectively exerted, so that the uniformity and dispersibility of the gelatine coating liquid is increased, and when dried to form a low-action soft capsule, it is soft and good chewability and solubility in the oral cavity. It is thought to give the gelatinous coating a soft rich taste.

Moreover, in general, when a substance other than gelatin, such as fat or oil, or a plasticizer is mixed with a coating liquid made of gelatin, a plasticizer, and water, the uniformity and dispersibility in the coating liquid are inferior, and adhesion between capsule coatings is also inhibited. It cannot be blended more than a certain amount (for example, 5 parts by weight based on 100 parts by weight of gelatin). However, in the present invention, a powdered fat or oil is used, which is characterized by dry powdering an O / W emulsion containing an oil or fat, a powdered base material, and an emulsifier. 5 parts by weight) or more, it is excellent in uniformity and dispersibility in the coating liquid, and it is possible to obtain a capsule having excellent adhesiveness without inhibiting the adhesion between the capsule films.

In addition, the capsule coating water immediately after capsule molding using a rotary die-type automatic soft capsule manufacturing machine is about 25 to 40%, and the process of drying the capsule coating water to about 7 to 15% using a tumble dryer after that. WHEREIN: The fats and oils derived from the powder fats and oils disperse | distributed uniformly to a capsule film are soaked in the capsule film surface, and the capsule surface is oil-coated with this fats and oils. By oil-coating the surface of capsules with the oil-derived oil or oil derived from powdered fats and oils, it is excellent in the prevention of adhesion to capsules and containers, and furthermore, the effect which suppresses the water rise of a gelatinous film is obtained even under high humidity conditions.

In addition, the tumble dryer which can be used in the capsule drying process of this invention promotes contact of a soft capsule and an atmosphere, rotating the drum which formed the gold mesh in the cylindrical shape, and aims at dissipation of the water contained in a soft capsule film. It is provided with an appropriate air supply mechanism and the like. Examples of such tumble dryers include Sankyo Co., Ltd. type: KTB type, OTB type, Kamata Co., Ltd. type: TDM-P5 type, TDM-SL5 type, and the like.

The present invention is not limited to the present example, and even if other components such as colorants such as caramel pigments and sweeteners are contained as a low-action soft capsule coating component together with powdered fats and oils, the soft and good While it is easy to prepare and dissolve, it does not impair the effect of inhibiting the increase of gelatinous film moisture even under high humidity conditions by giving the gelatinous film a soft umami and excellent adhesion between capsules and containers. Needless to say,

The powder fats and oils used for this invention are dry powdered O / W emulsion containing fats and oils, a powdered base material, and an emulsifier, However, any powder fats and oils which are marketed can be used. For example, the Miyoshi Yuji Co., Ltd. brand name magic pet 215, magic pet 110, magic pet 202, magic pet 250, magic pet 100, magic pet 200, magic pet 700, magic pet 1000, etc. can be used.

The fats and oils which can be used for the powder fats and oils of this invention can be used if it is suitable for edible, such as a liquid, solid animal fats and oils, hardened animal fats and oils, transesterified oils of animal and vegetable fats, fractionated liquid oils, or solid fats. Specifically, animal fats and oils such as vegetable oils such as rapeseed oil, corn oil, soybean oil, cottonseed oil, soybean oil, palm oil, palm oil, rice bran oil, sesame oil, cacao oil, olive oil, palm kernel oil, fish oil, pork, tallow, chicken oil, and fats and oils, And hardened oils or transesterified oils of these fats and oils, liquid oils obtained by fractionating these fats and oils, solid papers, and the like.

Powdered base materials which can be used for the powder maintenance of the present invention include milk protein, soy protein, wheat protein, whole milk powder, skim milk powder, wheat flour, starch, gelatin, whey, gum, monosaccharide, disaccharide, oligosaccharide, dextrin, maltodextrin and the like. These are mentioned, and they are one type or the combination of two or more types chosen from the group which consists of these. Especially, sucrose of dextrin, maltodextrin, oligosaccharide, and disaccharide is used preferably. When a reducing sugar is used as the powdered base of powdered fats and oils, there is a possibility that the decay delay and the brown color change may occur due to the mayrad reaction between the reducing sugar and the gelatin molecules derived from the soft capsule coating. However, when using a sucrose of dextrin, maltodextrin, oligosaccharide, and disaccharide as a powdered base of powdered fat, it is possible to prevent or inhibit browning change and decay delay caused by a maylad reaction with gelatin molecules such as when reducing sugar is used. It has a very good effect.

That is, in the present invention, a powdered fat or oil using dextrin, maltodextrin, oligosaccharide, and sucrose as a powdered base material is blended as a low-action soft capsule coating, so that the gelatine coating is soft in the oral cavity and has good chewability and solubility. It gives a soft and rich taste to the capsule film, and it is excellent in adhesion between capsules and adhesion between capsules and containers. Furthermore, even in high humidity conditions, it is possible to suppress the increase in moisture of the gelatine film, and to make powder oils and gelatin molecules It has a very good effect of preventing or suppressing the delay of disintegration and browning change by the lard reaction. As such powder fats and oils, the brand name Magicpet 215 (made of maltodextrin as a powdered base material), MagicPet 200 (made of dextrin as a powdered base material) etc. by Miyoshi Yuji Co., Ltd. are mentioned, for example.

Examples of the milk protein include acid casein, rennet casein, sodium caseinate, and the like, and starch may include octenylsuccinic acid starch, potato starch, corn starch, wheat starch, and tacapio starch. Examples of the gum include xanthan gum, gum arabic, tragacanth gum, gellan gum, locust bean gum, tamarind seed gum, carrageenan, agar, LM pectin, HM pectin and the like.

The emulsifier that can be used for the powder fat and oil of the present invention may be any one that increases the emulsifying power of O / W, but is not particularly limited. For example, glycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, propylene glycol fatty acid ester, lecithin, Emulsified processed starch (octenylsuccinic acid starch) and the like.

The powder fats and oils used for this invention are dry powdered O / W emulsion containing fats and oils, a powdered base material, and an emulsifier, As a method of dry-powdering an O / W emulsion, it is spray drying method and vacuum freezing. Drying method, vacuum drying method, etc. can be used.

Although the compounding quantity in the low action soft capsule film of the powder fats and oils used for this invention may be suitably determined in consideration of the expected effect, etc., it is preferably used in 1-30 weight part with respect to 100 weight part of gelatin. More preferably 5 to 20 parts by weight, particularly preferably 7.5 to 15 parts by weight, still more particularly preferably 10 to 12.5 parts by weight. When the compounding quantity in the capsule coating of powdered fats and oils is 1 weight part or less with respect to 100 weight part of gelatin, an effect is hard to express, and when it is 30 weight part or more, the taste of a powder fats and oil component becomes too strong and there exists a tendency for the balance of the taste of a capsule film to be inferior. .

The average particle diameter of the powder fats and oils used for this invention is 0.3-3 micrometers, More preferably, it is 0.5-2 micrometers, Especially preferably, it is 0.7-1.5 micrometers, More preferably, it is 0.9-1.1 micrometers. If the average particle diameter of the powder fats and oils used for this invention is 0.3 micrometer or less, it will be hard to give a soft taste to gelatin film, and if it is 3 micrometers or more, there exists a tendency for the uniformity and dispersibility in a capsule film solution to be inferior.

Gelatin that can be used in the present invention is a protein of tens of thousands to hundreds of thousands of proteins obtained by breaking down and purifying a protein called collagen mainly contained in bones, skins, or tendons, such as cattle, pigs, chickens, and fish. As long as it is gelatin, any can be used.

The plasticizer which can be used in the present invention includes glycerin, sugar alcohols, propylene glycol, polyethylene glycol, monosaccharides, disaccharides, oligosaccharides, isomaltooligosaccharides, polydextroses, and the like. It is a combination of two or more kinds.

Examples of the sugar alcohols include erythritol, lactitol, maltitol, mannitol, sorbitol, and xylitol. Examples of the monosaccharides include glucose, fructose, mannose, galactose, ribose, xylose, and arabinose. Examples of the disaccharides include sucrose, maltose, lactose and trehalose.

Moreover, what is necessary is just to determine the compounding ratio of a plasticizer suitably in consideration of the effect etc. expected, and it is used suitably at 30-300 weight part with respect to 100 weight part of gelatin. More preferably, it is 80-250 weight part, Especially preferably, it is 90-200 weight part, More preferably, it is 100-150 weight part. If the blending ratio of the plasticizer is 30 weight or less, the strength and elasticity of the capsule film are not sufficient. If the content is 30 parts by weight or more and 80 parts by weight or less, the capsule strength is high, but the capsule film is hard and not chewed, and thus tends to be inferior in chewability. When the blending ratio of the plasticizer is increased from 80 parts by weight, the chewability is good, but when it is 250 parts by weight or more, the adhesiveness of the capsule film is increased, resulting in inferior manufacturing stability, and inferior adhesion between capsules after production. .

In the low-action soft capsule coating of the present invention, in addition to the gelatin, plasticizer, powder fats and oils, water sweetener can be further blended in consideration of the expected effect. As a sweetener which can be used for this invention, aspartame, disodium glycyrrhizinate, sodium saccharin, stevia, somartin, etc. are mentioned, It is one type or two or more types selected from the group which consists of these. For the sake of convenience, sugar alcohols, propylene glycol, polyethylene glycol, monosaccharides, disaccharides, oligosaccharides, and the like, which have been mentioned as plasticizers, are excluded from the definition of sweeteners, and these may be used as sweeteners.

Moreover, what is necessary is just to determine the compounding ratio of a sweetener suitably in consideration of the effect etc. expected, and it is used preferably at 5-100 weight part with respect to 100 weight part of gelatin. More preferably, it is 10-80 weight part, Especially preferably, it is 15-30 weight part.

In the low-action soft capsule film of the present invention, in addition to the gelatin, plasticizer, powder fats and oils, in addition to sweeteners, colorants, preservatives, disintegrating agents, fragrances, copulation agents, odorants, anti-adhesive agents, etc. It can mix.

For example, starch can be combined with gelatin, plasticizer, powder fats and oils in a low-acting soft capsule film to give irregularities on the surface of the capsule film, thereby improving the anti-adhesion between the capsules by synergistic effects with the powder fat and oil formulation. have.

Moreover, since starch can contain 5-50 weight% of water normally and has a water retention effect, it gives viscosity to the capsule coating sheet at the time of manufacture using a rotary die-type automatic soft capsule manufacturing machine, and a mold, a casting drum, etc. The peelability of can be raised and the manufacturing stability of a capsule can be improved. Moreover, the chewability of a capsule film can also be improved by the repair action of starch.

In addition, starch is a hydrophobic substance inherently, and is partially hydrophobized by a pressure (for example, 150 to 200 kg / cm 2) received from a mold at the time of capsule manufacture using a rotary die-type automatic soft capsule maker, It also acts as a. Therefore, even if it mix | blends relatively large (for example, 30 weight part with respect to 100 weight part of gelatin), the capsule which has the outstanding adhesiveness can be obtained, without inhibiting the adhesion of capsule films.

Therefore, the blending ratio of starch may be appropriately determined in consideration of expected effects and the like, but is preferably used at 10 to 60 parts by weight with respect to 100 parts by weight of gelatin. More preferably, it is 15-50 weight part, Especially preferably, it is 20-40 weight part.

In addition, as the contents of the low-action soft capsule of the present invention, the encapsulation is a mixture of all kinds of fats and oils such as vegetable oil, animal oil, a combination of vegetable oil and animal oil, and also suspension oil containing animal and vegetable extracts and extract powder in each fat and oil. All functional materials can be used.

Specific examples of capsule contents that can be used in the present invention include royal jelly, propolis, mushroom extract, lacey, pine needle extract, ginkgo biloba extract, blotch extract, chlorella, spirulina, octacosanol, aloe, ezokocogi, Korea Ginseng, Ukon, Cordyceps sinensis, Doojung extract, Garlic, Candle, Black vinegar, Herb, Rutin, Kimnema, Soybean peptide, Heart extract, Herb, Yeast, Enzyme, Seal extract, Deep sea shark extract, Zara extract, Pracenta extract, Salsa, Maro extract, persimmon extract, bifidus bacteria, lactic acid bacteria, chitin, chitosan, taurine, nucleic acid, oligosaccharides, senzone Worth, valerian, echinacea, soybean isoflavone, evening primrose oil, green tea catechin, polyphenol , Blueberry, lycopene, agaricus, edible, molohey, glucosamine, chondroitin, hyaluronic acid, collagen, DHA, EPA, germinated brown rice, silymarin, cysteine peptide, leci Tin, β-carotene, vitamin E, ceramide, squalene, pomegranate extract, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, vitamin A, vitamin K1, vitamin K2, vitamin D, nicotinic acid, nicotinamide, pantothenic acid Biotin, Carotene, Sarasia, Garcinia, Chilli Capsaicin, Carnitine, Plant Fiber, Mulberry Leaf, Indigestible Dextrin, Peptides, Folic Acid, Calcium, Magnesium, Lithium, Zinc, Chromium, Manganese, Phosphorus, Sodium, Potassium, Chloride, Sodium Chloride , Iron, copper, germanium, silicon, selenium, maca, squalene, honey, pollen, glycine, alanine, valine, leucine, isoleucine, phenylalanine, proline, serine, threonine, cysteine, cystine, methionine, tripofane, tyrosine, Hydroxyproline, asparagine, glutamine, asparagine, glutamic acid, lysine, arginine, histidine, ashwaganda, β1,3 glucan, birberry, boswellia (canran), bovine organs Bone, Broccoli Extract, Bromelain, Cat's Claw, Cetyl-Mistrite, Chlorella, Picolinate Chromium, Chihuahua, Coenzyme Q10, Conjugated Linoleic Acid, Kawaratake Extract (Kurestin), Creatine, Cryptoxanthin, Cinna Lean, licorice, tal glycyrrhizin licorice, elder extract (seiyouniwatko), emu oil, flaxseed oil, forskolin (choles), glycerol, google lipid, 5-hydroxytryptophan, hemp oil, hydroxycitric acid, Hydroxyapatite, lactoferrin, L-carnitine, lipoic acid, lutein, mitake extract, malic acid, heavy chain fatty acid, melatonin, crude citrus pectin (MCP), monolaurin, methylsulfonylmethane, progesterone, nim, olive lip extract , Organo oil, piperine, phosphatidylcholine, pregnenolone, proanthocyanidins, phidium, quercetin, resveratrol, rosemary, nokogiriyashi, sirimarin, soma, trimethylglycine Vanadium sulfate, whey, yohinbin, zeaxanthin, androstenedione, glycine, caffeine, and the like, and can be used as capsule contents in one or two or more kinds thereof. However, needless to say, it is not limited to these.

In addition, in the present invention, as a sweetener in the capsule contents, aspartame, sodium glycyrrhinate, sodium saccharin, stevia, somatin, glycerin, sugar alcohol, propylene glycol, polyethylene glycol, monosaccharides, disaccharides, oligosaccharides, isomaltole oligosaccharides, polydex Troose etc. can be used suitably.

Examples of the sugar alcohols include erythritol, lactitol, maltitol, mannitol, sorbitol, and xylitol. Examples of the monosaccharides include glucose, fructose, mannose, galactose, ribose, xylose, and arabinose. Examples of the disaccharides include sucrose, maltose, lactose and trehalose, but needless to say, these are not limited thereto.

As a package of low-action soft capsules, there are bottled packaging, bagged packaging, and the like. In the conventional bottled packaging and the bag packaging, silica gel is used to prevent deterioration such as adhesion resistance. It was necessary to package a low-action soft capsule with a desiccant made of calcium oxide, calcium chloride, silica alumina gel and the like.

However, in the low-action soft capsule containing the powdered fat or oil of the present invention, since it has the effect of suppressing the increase of the gelatinous film moisture even under high humidity conditions, there is no need to package a drying agent such as silica gel as in the prior art. It also has an excellent effect on productivity and cost.

According to the present invention, soft and good chewability and solubility in the oral cavity, the gelatine coating gives a soft umami, excellent adhesion of the capsule coating, anti-adhesion between capsules and containers, furthermore, high humidity conditions Even in the following cases, the gelatinous film is suppressed to increase the moisture, and when it is packed in a bottle or packed in a bag, it does not require a desiccant such as silica gel, and has no conventional low-action software which is excellent in productivity, cost, and quality. You can get a capsule.

Although an Example is shown to the following and this invention is demonstrated in more detail, this invention is not limited to this.

<Test Example 1>

(1) Comparative Examples 1-2

In the low-action soft capsule coating formulation of Comparative Example 1 of Table 1, after mixing 50 kg (100 parts by weight) of gelatin, 50 kg (100 parts by weight) of glycerin, and 35 kg (70 parts by weight) of RO water after mixing It heated and dissolved at about 70 degreeC, and vacuum-defoamed, and obtained the gelatin sheet composition. The composition was made to flow uniformly on a stainless steel metal plate (about 50 cm x 50 cm), and the gelatin sheet moisture was dried at 9 to 10% by weight at about 25 ° C to obtain a gelatin sheet having a thickness of about 0.5 mm. About 1 cm x 1 cm chip | tip was cut out from the gelatin sheet, and the gelatin sheet chip | tip comparative example 1 was obtained. In addition, RO of RO number is an abbreviation of (Reverse Osmosis).

A gelatin sheet chip comparative example 2 was obtained in the same manner as in Comparative Example 1 except that 5 kg (10 parts by weight) of fats and oils (trade name of Nisshin Oilio Group Co., Ltd .: Nisshin Sapflower Oil) was formulated in Table 1.

(2) Invention 1 to 5

Next, the low-action soft capsule coating formulation of the present invention 1 shown in Table 1, according to a conventional method, gelatin 50 kg (100 parts by weight), glycerin 50 kg (100 parts by weight), powder oils and fats After mixing 1.25 kg (2.5 weight part) of PET 215 and 35 kg (70 weight part) of RO water, it heated-dissolved at about 70 degreeC, and vacuum-defoamed, and obtained the gelatin sheet composition. The composition was made to flow uniformly on a stainless steel metal plate (about 50 cm x 50 cm), and the gelatin sheet moisture was dried at 9 to 10% by weight at about 25 ° C to obtain a gelatin sheet having a thickness of about 0.5 mm. About 1 cm x 1 cm chip | tip was cut out from the gelatin sheet, and the gelatin sheet chip this invention 1 was obtained.

In the same manner as in the present invention 1, a gelatine sheet chip the present inventions 2 to 5 were obtained by the capsule coating formulation of Table 1.

In addition, gelatin and glycerin are common in Comparative Examples 1-2 and this invention 1-5, gelatin uses the brand name Weishardt GXAS-7 by a Buishalt company, and glycerin is sold by Kenko Co., Ltd. VVF LTD. The brand name REFINED GLYCERINE USP was used.

<Evaluation item>

(1) sensory evaluation

By seven panelists, the sensory evaluation was performed about the 1) chewability, 2) solubility, and 3) taste in the oral cavity of the gelatin sheet chip of Comparative Examples 1-2 and this invention 1-5.

(2) Evaluation of adhesion prevention

Moreover, the gelatin sheet chip of Comparative Examples 1-2 and this invention 1-5 was put into the glass sample bottle No. 6, and it preserve | saved for 48 hours in the constant temperature and humidifier of 40 degreeC of temperature and 75% RH of humidity with a cap closed. In this case, the anti-adhesion properties of the gelatin sheet chips were evaluated.

The results of the sensory evaluation and the anti-sticking evaluation are shown in Table 2 below.

When comparing the evaluation results of the anti-adhesion evaluation results of Comparative Examples 1-2 and the present inventions 1-5, in Comparative Example 1, chewing properties and solubility in the oral cavity were poor, and a fresh taste peculiar to the gelatinous coating remained. Moreover, adhesion of the sheet after storage was also remarkable. In Comparative Example 2 in which fats and oils were further added to the coating formulation of Comparative Example 1, the chewing property, the fresh taste peculiar to the gelatinous coating, and the adhesiveness of the sheet after storage were improved from Comparative Example 1, but the solubility in the oral cavity was inferior. It was.

On the other hand, in the present inventions 1-5 which mix | blended powdered fats and oils, chewability and solubility in oral cavity were favorable, the fresh taste peculiar to a gelatinous membrane was improved, and the gelatinous membrane had a soft flavor. Moreover, there was no sticking of the sheet after storage, and it was soft.

What is necessary is just to manufacture a soft capsule according to the regular method in order to implement this invention, For example, methods, such as a rotary type, a seamless type, or a flat type, can be used. As a soft capsule manufacturing method by the rotary die type automatic soft capsule manufacturing machine which is an example of a rotary type | system | group, the method disclosed by Paragraph No. 0024-0031 of Unexamined-Japanese-Patent No. 2004-351007 which the applicant has already patented can be used.

Although an Example is shown to the following and this invention is demonstrated to it in detail, this invention is not limited to this, As a capsule content, vegetable oil, animal oil, a combination of vegetable oil and animal oil, Furthermore, the flora and fauna extract and extract for each fats and oils are mentioned. It can be applied to all that can be encapsulated in a mixture with all kinds of fats and oils, such as suspension oil containing powders.

<Test Example 2>

(1) Comparative Examples 1´ to 2´

50 kg (100 parts by weight) gelatin, 50 kg (100 parts by weight), glycerin 50 kg (100 parts by weight), RO water 35 kg (70 parts by weight) were mixed according to a conventional method in the low-action soft capsule coating formulation of Comparative Example 1´ of Table 3. Thereafter, the resulting mixture was warmed and dissolved at about 70 ° C., and subjected to vacuum defoaming to be used for molding gelatin capsules.

The shaping | molding of the capsule was performed using the rotary die type automatic soft capsule manufacturing machine, and selected No. 5 oval to a metal mold | die. As the contents of the capsule, 300 mg of `` MCT (medium chain fatty acid triglyceride): soybean lecithin = 50: 50 (% by weight) '' was filled and molded, followed by a capsule using a tumble dryer type manufactured by Sankyo Co., Ltd .: KTB type. It dried so that water of a film might be 8.2 to 8.7 weight%, and obtained the soft capsule of the comparative example 1 '. As MCT of capsule content, the brand name of Co., Ltd. | Coconad MT was used. Soybean lecithin was used by J-OILMILLS Co., Ltd. brand name: J lecithin CL.

A soft capsule comparative example 2 'was obtained in the same manner as in Comparative Example 1' except that 5 kg (10 parts by weight) of fats and oils (trade name of Nisshin Oilio Group Co., Ltd .: Nisshin Sapflower Oil) was formulated in Table 3. .

(2) Invention 1 'to 5'

Next, according to the conventional method, 50 kg (100 weight part) of gelatin, 50 kg (100 weight part) of glycerin, and powdered fats and oils (Miyoshi Oils Corporation make) After mixing 1.25 kg (2.5 parts by weight) of MagicPet 215 and 35 kg (70 parts by weight) of RO water, the solution was warmed and dissolved at about 70 ° C., and subjected to vacuum defoaming to be used for molding gelatin capsules.

The shaping | molding of the capsule was performed using the rotary die type automatic soft capsule manufacturing machine, and selected No. 5 oval to a metal mold | die. As the contents of the capsule, 300 mg of `` MCT (medium chain fatty acid triglyceride): soybean lecithin = 50: 50 (% by weight) '' was filled and molded, followed by a capsule using a tumble dryer type manufactured by Sankyo Co., Ltd .: KTB type. It dried so that the moisture of film might be 8.2-8.7 weight%, and the soft capsule of this invention 1 'was obtained. MCT and soybean lecithin of the capsule contents used the same thing as the comparative example 1 '-2'.

In the same manner as in the invention 1 ′, the soft capsules of the inventions 2 ′ to 5 ′ were obtained by the coating formulations shown in Table 3.

In addition, gelatin and glycerin are common in Comparative Examples 1 '-2' and this invention 1 '-5', and gelatin uses the brand name Weishardt GXAS-7 by a Buishalt company, and glycerin is Kenko Co., Ltd. The brand name REFINED GLYCERINE USP by the VVF LTD company was used for sale.

<Evaluation item>

(1) sensory evaluation

By seven panelists, sensory evaluation was performed about 1) chewability, 2) solubility, and 3) taste in the oral cavity of the capsule coating of Comparative Examples 1 '-2' and this invention products 1 '-5'.

(2) Evaluation of adhesion prevention

The soft capsules of Comparative Examples 1 'to 2' and the inventive products 1 'to 5' were placed in a No. 6 glass sample bottle, and stored for 48 hours in a constant temperature / humidifier at a temperature of 40 ° C and a humidity of 75% RH with the cap closed. The adhesion prevention property of the soft capsule of one case was evaluated.

(3) adhesive evaluation

The capsules were cut | disconnected in half after the soft capsule shaping | molding of Comparative Examples 1'-2 'and this invention 1'-5', and the adhesiveness was evaluated through the microscope observation.

(4) Evaluation of film moisture value increase suppression

1) Measurement of film moisture value

The soft capsules of Comparative Examples 1 ′ to 2 ′ and the inventive products 1 ′ to 5 ′ were placed in a No. 6 glass sample bottle, and the caps were closed at 0 ° C. for 2 days in a constant temperature and humidity chamber at 40 ° C. and 75% RH. , The moisture value of the soft capsule film in the case of storing for 4 days was measured, and 10 average values were computed. In addition, the measurement of the moisture value was measured using the heat-drying moisture meter (made by A & D Co., Ltd., model name: MX-50).

2) Film moisture value increase rate

The rate of increase of the film moisture value was calculated by the following equation.

Film moisture value increase rate (%)

= (Moisture value after 2 days or 4 days-water value on day 0) ÷ water value on day 0 × 100

In addition, in this invention, moisture absorption of a capsule film is suppressed so that there is little film moisture value increase rate, and it can be said that it is suitable as a low action soft capsule of this invention.

3) Inhibition effect of film moisture value increase

Based on each numerical value determined by said 1) measurement of film moisture value, and 2) film moisture value increase rate, the soft capsule film moisture value increase suppression effect of the comparative examples 1 '-2' and this invention 1 '-5' was evaluated. .

Table 4 shows the results of (1) sensory evaluation, (2) anti-adhesion evaluation, (3) adhesion evaluation, and (4) film moisture rise inhibition evaluation.

When the results of sensory evaluation of the low-action soft capsules of the present inventions 1 'to 5' of Comparative Examples 1 'to 2' of Table 4 compare the results of the anti-sticking evaluation results, the comparative examples 1 to 2 of Table 2 and the inventions 1 to 2 are compared. The same trend as the evaluation result of 5 was shown.

That is, in Comparative Example 1 ', chewability and solubility in the oral cavity were poor, and a fresh taste peculiar to the gelatinous coating remained. Moreover, the adhesion of the soft capsule after storage was also remarkable. In Comparative Example 2 ', in which fats and oils were further added to the coating formulation of Comparative Example 1', the chewability, the fresh taste peculiar to the gelatinous coating, and the adhesion of soft capsules after storage were improved compared to Comparative Example 1 '. Solubility in was inferior.

On the other hand, in the present inventions 1 'to 5' formulated with powdered fats and oils, chewability and solubility in the oral cavity were good, and the fresh taste peculiar to the gelatinous coating was improved, and the gelatinous coating had a soft flavor. Moreover, there was no adhesion of the soft capsules after storage, and it was soft.

When comparing the film moisture value increase suppression effect in Table 4, compared with the comparative example 1 'which did not add powdered fats and oils, in this invention 1'-5' which added powdered fats and oils, the tendency which the increase of a film moisture value is suppressed is suppressed. This was confirmed. Moreover, in Comparative Example 1 ', the adhesiveness of the inventions 1'-5' was favorable at the same level.

On the other hand, in Comparative Example 2 ', the same effect as the present invention 1' to 5 'was observed, but the film moisture value suppressing effect was confirmed. The phenomenon was confirmed. In addition, this "liquid leakage" was not confirmed in Comparative Examples 1 'and 1'-5' of this invention with favorable adhesiveness.

<Test Example 3>

Comparative Example 1 'of Table 3, Table 4, a coating formulation, a capsule content, and a manufacturing method were made the same, and the low-action soft capsule Comparative Example 3 and Comparative Example 4 of Table 5 were obtained. Moreover, the invention formulation 3 'of Table 3, Table 4, the coating formulation, the capsule contents, and the manufacturing method were made the same, and the low-action soft capsule this invention 6 of Table 5 was obtained.

The film moisture value of each capsule was adjusted to 10.0-10.4 weight% using the tumble dryer type | mold: KTB type by Sankyo Corporation. In Comparative Example 3 and Comparative Example 4, 150 capsules were put together in the No. 12 glass bottle, and the cap was closed. In Comparative Example 3, the silica gel desiccant was not added, and the Comparative Example 4 was 1 g of silica gel desiccant ( Oe Chemical Industry Co., Ltd. brand name silica gel QP1) was put.

In the present invention 6, 150 capsules were placed in a No. 12 glass bottle, and the cap was closed without the silica gel desiccant.

(1) sensory evaluation

By seven panelists, the capsule of 0 months storage immediately after manufacture of the comparative example 3, the comparative example 4, and this invention 6, and the capsule of 6 months storage at 20 degreeC, 25% RH are 1 in the oral cavity of a capsule film. A sensory evaluation was performed on a) chewability, 2) solubility, and 3) taste. The evaluation results are shown in Table 5.

(2) Evaluation of adhesion prevention

Immediately after the manufacture of Comparative Example 3, Comparative Example 4, and the invention 6, the anti-adhesion properties of the capsules stored for 0 months and the soft capsules of the capsules stored for 6 months at 20 ° C and 25% RH were evaluated. The evaluation results are shown in Table 5.

Comparing the evaluation results of Table 5, in Comparative Example 3 without the desiccant, the anti-sticking property was lowered by preservation for 6 months. there was.

On the other hand, in the present invention 6, although no desiccant was added, even if it was stored for 6 months, there was almost no change in the target over time for the chewability, the solubility, the taste, and the antifouling property, and the quality was maintained satisfactorily.

Industrial availability

INDUSTRIAL APPLICABILITY The present invention can be used in the field of industry, such as those containing industrial preparations, for example, by the selection of the contents in addition to the fields of `` pharmaceuticals '', `` specific health foods '', `` so-called health foods '' and foods. .

Claims (10)

In the soft capsule which carries out the drying of the capsule film which forms a capsule main body after filling a film with the content,
The film portion is a low-action soft capsule, characterized in that formed by containing gelatin, plasticizer, powdered fat, water. The method of claim 1,
The compounding quantity in the film of the said plasticizer is 80-250 weight part with respect to 100 weight part of gelatin,
A low-action soft capsule characterized in that the powder oil is dried powdered O / W emulsion containing a fat or oil, a powdered base material, and an emulsifier. The method according to claim 1 or 2,
The compounding quantity in the film of the said powder fats and oils is 1-30 weight part with respect to 100 weight part of gelatin, The low action soft capsule characterized by the above-mentioned. The method according to claim 1, 2, or 3,
After filling the film with the contents, in the process of drying the low-action soft capsule film using a tumble dryer, oil-derived oils derived from powdered oil uniformly dispersed in the capsule film are soaked on the capsule film surface. The low action soft capsule characterized in that the surface of the capsule is coated with oil. The method according to claim 1, 2, 3 or 4,
A low-action soft capsule, wherein the powdered base material as a component of the powdered fat or oil is one or a combination of two or more selected from the group consisting of dextrin, maltodextrin, oligosaccharide, and sucrose. The method according to claim 1, 2, 3, 4 or 5,
The low-action soft capsule of the said powder fats and oils whose average particle diameter is 0.3-3 micrometers. The method according to claim 1, 2, 3, 4, 5 or 6,
A low-action soft capsule wherein the plasticizer is one or a combination of two or more selected from the group consisting of glycerin, sugar alcohols, propylene glycol, polyethylene glycol, monosaccharides, disaccharides, oligosaccharides, isomaltooligosaccharides and polydextrose. The method according to claim 1, 2, 3, 4, 5, 6, or 7,
A low-acting soft capsule comprising adjusting gelatin, plasticizer, powdered fat, and water in adjusting the coating part to improve adhesion prevention, chewability in the oral cavity, solubility, and soft taste. The method according to claim 1, 2, 3, 4, 5, 6, 7, or 8,
In adjusting the said coating part, the low action soft capsule which suppressed the raise of gelatin film moisture by containing gelatin, a plasticizer, powder fats, and water. The method according to claim 1, 2, 3, 4, 5, 6, 7, 8, or 9,
In adjusting the said coating part, by containing gelatin, a plasticizer, powder fats, and water, the rise of gelatin film moisture is suppressed,
A low-acting soft capsule, which is packaged in a bottle or packaged without using a desiccant which is one or a combination of two or more selected from the group consisting of silica gel, calcium oxide, calcium chloride and silica alumina gel.