KR20110025827A - 신경섬유종증을 위한 치환된 벤즈이미다졸 - Google Patents

신경섬유종증을 위한 치환된 벤즈이미다졸 Download PDF

Info

Publication number
KR20110025827A
KR20110025827A KR1020117000776A KR20117000776A KR20110025827A KR 20110025827 A KR20110025827 A KR 20110025827A KR 1020117000776 A KR1020117000776 A KR 1020117000776A KR 20117000776 A KR20117000776 A KR 20117000776A KR 20110025827 A KR20110025827 A KR 20110025827A
Authority
KR
South Korea
Prior art keywords
alkyl
formula
neurofibromatosis
halo
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020117000776A
Other languages
English (en)
Korean (ko)
Inventor
다린 스튜어트
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20110025827A publication Critical patent/KR20110025827A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020117000776A 2008-06-13 2009-06-11 신경섬유종증을 위한 치환된 벤즈이미다졸 Withdrawn KR20110025827A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6115608P 2008-06-13 2008-06-13
US61/061,156 2008-06-13

Publications (1)

Publication Number Publication Date
KR20110025827A true KR20110025827A (ko) 2011-03-11

Family

ID=40956523

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117000776A Withdrawn KR20110025827A (ko) 2008-06-13 2009-06-11 신경섬유종증을 위한 치환된 벤즈이미다졸

Country Status (12)

Country Link
US (1) US20110092546A1 (https=)
EP (1) EP2288354A1 (https=)
JP (1) JP2011524362A (https=)
KR (1) KR20110025827A (https=)
CN (1) CN102065859B (https=)
AU (1) AU2009257487B2 (https=)
BR (1) BRPI0915106A2 (https=)
CA (1) CA2726376A1 (https=)
MX (1) MX2010013683A (https=)
RU (1) RU2011100106A (https=)
TW (1) TW201004621A (https=)
WO (1) WO2009152288A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101880015B1 (ko) 2017-12-08 2018-07-19 아주대학교산학협력단 인터페론 감마를 유효성분으로 함유하는 신경섬유육종 예방 또는 치료용 조성물

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9540443B2 (en) 2011-01-26 2017-01-10 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies
CN116574185A (zh) 2012-07-25 2023-08-11 塞尔德克斯医疗公司 抗kit抗体及其用途
CN113908269A (zh) 2014-05-23 2022-01-11 塞尔德克斯医疗公司 嗜酸性粒细胞或肥大细胞相关病症的治疗
EP3908278A4 (en) 2019-01-11 2022-09-28 Naegis Pharmaceuticals Inc. INHIBITORS OF LEUKOTRIEN SYNTHESIS
CN117460509B (zh) * 2021-06-23 2025-03-28 正大天晴药业集团股份有限公司 作为c-Met激酶抑制剂的化合物治疗I型神经纤维瘤病的用途
EP4412610A1 (en) * 2021-10-08 2024-08-14 Université Claude Bernard Lyon 1 Benzimidazole derivatives for use in the treatment or prevention of a histiocytosis or a craniopharyngioma

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ535985A (en) * 2002-03-29 2007-04-27 Chiron Corp Substituted benzazoles and use thereof as RAF kinase inhibitors
PE20070335A1 (es) * 2005-08-30 2007-04-21 Novartis Ag Benzimidazoles sustituidos y metodos para su preparacion
GB0609378D0 (en) * 2006-05-11 2006-06-21 Novartis Ag Organic compounds
PE20080766A1 (es) * 2006-08-30 2008-06-15 Novartis Ag Sales de benzimidazolil piridil eteres y formulaciones que las contienen
US20100074897A1 (en) * 2006-12-01 2010-03-25 University Of Utah Research Foundation Methods and Compositions related to HIF-1 alpha
UA99731C2 (ru) * 2007-07-30 2012-09-25 Ардеа Биосайенсис, Инк Кристаллические полиморфные формы n-(ариламино)сульфонамидов как ингибиторы мэк, композиция (варианты) и применение
WO2009114703A2 (en) * 2008-03-12 2009-09-17 Fox Chase Cancer Center Combination therapy for the treatment of cancer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101880015B1 (ko) 2017-12-08 2018-07-19 아주대학교산학협력단 인터페론 감마를 유효성분으로 함유하는 신경섬유육종 예방 또는 치료용 조성물

Also Published As

Publication number Publication date
CN102065859A (zh) 2011-05-18
BRPI0915106A2 (pt) 2016-02-10
CN102065859B (zh) 2012-10-03
EP2288354A1 (en) 2011-03-02
RU2011100106A (ru) 2012-10-27
US20110092546A1 (en) 2011-04-21
AU2009257487B2 (en) 2013-01-31
WO2009152288A1 (en) 2009-12-17
JP2011524362A (ja) 2011-09-01
TW201004621A (en) 2010-02-01
AU2009257487A1 (en) 2009-12-17
MX2010013683A (es) 2011-04-26
CA2726376A1 (en) 2009-12-17

Similar Documents

Publication Publication Date Title
EP2640467B1 (en) Crystalline form of an inhibitor of mdm2/4 and p53 interaction
US11096947B2 (en) Combination products with tyrosine kinase inhibitors and their use
US8859586B2 (en) Cyclohexyl isoquinolinone compounds
AU2009257487B2 (en) Substituted benzimidazoles for neurofibromatosis
US20110118309A1 (en) Use of hdac inhibitors for the treatment of hodgkin's disease
EP3174869A1 (en) Combination therapy
EP2391366B1 (en) Substituted benzimidazoles for the treatment of astrocytomas
WO2010009285A1 (en) Use of hdac inhibitors for the treatment of acute myeloid leukemia and/or myelodysplastic syndrome
HK40064964A (en) Combination products with tyrosine kinase inhibitors and their use
HK1184091B (en) Crystalline form of an inhibitor of mdm2/4 and p53 interaction

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20110112

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid