KR20110015172A - A composition of plants extract for dysmenorrhea in women - Google Patents

Abstract

PURPOSE: A composition containing plant extract for treating menstrual irregularity without side effects is provided. CONSTITUTION: A composition for treating menstrual irregularity contains extract of Cnidium officinale Makino, Angelica gigas Nakai, Trigonella foenum-graecum, Pyrola japonica, and Corydalis turtschaninovii. The composition is used in the form of solution, suspension, emulsion, gel, tablet, and pill.

Description

A composition of plants extract for Dysmenorrhea in women}

The present invention relates to a plant extract composition for improving female menstrual irregularities.

Menstrual irregularity generally refers to irregular menstruation and is a symptom that may be caused by ovulation or rare ovulation. Diseases that can cause rare or no ovulation include polycystic ovary syndrome, ovulation disorders due to stress or eating disorders (anorexia or bulimia), pituitary tumors, adrenal tumors, benign pelvic tumors, malignant genital tumors, hyperthyroidism, thyroid gland Endocrine diseases such as hypofunction, hyperprolactinemia and the like. Polycystic ovary syndrome is a relatively common disease in young women of childbearing age, and even normal women show 5-10% polycystic ovary on ultrasound, but 30-60% of patients with infertility have polycystic ovary syndrome. . In addition to infertility, the polycystic ovary syndrome is reported to be a cause of repeated miscarriage, and interest is increasing. Polycystic ovary syndrome has not yet been fully etiological or pathophysiological, and is diagnosed with abnormal menstruation such as menstrual dysmenorrhea or amenorrhea, clinical symptoms such as hirsutism, obesity, infertility and acne and imbalance of female hormones. can do. In women with normal pelvis, primary dysmenorrhea usually involves pain during puberty. There is pelvic pain caused by menstruation before and after menstruation and it lasts 3 or 4 days. It has been reported that 20-90% of menstrual disorders occur in puberty, of which about 15% have severe menstrual disorders (1-4). In addition, 10% of 24-year-olds suffer from menstrual cramps, and most of them resolve their own painkillers, and only a few consult with their doctors (1-3).

Menstrual pain is a common symptom in gynecology. The absence of an organic pelvic lesion is classified as a primary or an accompanying organic lesion. 52% of women who are older than puberty complain of menstrual cramps, 10% of whom are incapable of doing anything for one to three days each month, the most common cause for young women to leave work or school. Pain is often convulsive or vibrating and is limited to the lower abdomen and upper pubis but sometimes extends to the lower back and legs. The cause of dysmenorrhea is believed to be the result of excessive contraction of the uterine muscle by prostaglandins secreted by the endometrium in primary cases, which is increased by the alpha-adrenergic receptor, which is a hormone and mental It is encountered by factors and is more frequent in people with mental anxiety and neurotic predisposition. Secondary cases include endometriosis, uterine fibroids, uterus or contraceptive device, chronic pelvic inflammatory disease, congenital malformations of the uterus, and the like. Treatment should be based on treatment of these organic lesions, and in primary cases, the symptoms improve spontaneously with age and are alleviated at 80-90% after the first delivery.

Menstruation is a physiological form in which the endometrium is eliminated after proliferation according to the ovulation cycle. Menstrual abnormality refers to abnormal cycles of menstrual cycle and bleeding abnormalities.

Hypermenorrhea is when the amount is too small compared to the average menstruation. The ovulation menstruation, uterine dysplasia, uterine atrophy, endometrial adhesion (after endometrial inflammation or abortion), and pregnancy may be the cause. Transient menstruation refers to a case where the amount is too large compared to the average menstruation, and the cause is divided into ovarian type and uterine type. Ovarian type is accompanied by ovulation disorders such as polycystic follicle, and uterine type is often due to uterine fibroids, natural miscarriage, endometrial proliferation, cervical disease, and the like.

Amenorrhea refers to the suspension of menstruation for more than three months in women who have been menstruating.

Causes include pregnancy, oral contraceptives, menopause, stress, ovaries, hysterectomy, pituitary gland, hypothalamic thyroid gland, parathyroid gland, adrenal gland, ovary, endocrine system problems, diabetes, tuberculosis, obesity, anorexia nervosa, anorexia nervosa Risk factors include stress, psychosis, and hormones. Prevention and treatment should not be stressed, and amenorrhea caused by the disease is often improved by treating the cause. However, if the cause is unknown and women in menopause does not have a special treatment.

As described above, there is an urgent need to develop a therapeutic agent for treating menopausal dysmenorrhea or ovulation or unexplained dysmenorrhea and polycystic follicles.

Baekjak is a perennial herb of the dicotyledonous plant of the genus Minari celestial parsley, also known as Gangjak. It grows in deep mountains. It is 40-50cm in height. Roots are thick, fleshy, and the base is covered with scale-like leaves. Leaves are alternately 3-4 in number and split 2 times in 3 pieces. Small leaves are long oval or upside down, with flat edges and no hairs.

Flower is white in June, 4 ~ 5cm in diameter, hang one by one at the end of main stem. Calyxes are egg-shaped, 3 pieces, petals are upside down, 5-7 pieces. There are several surgeries with three to four ovaries. Fruits are oligopods that, when opened, show reddish, less-grown red seeds and mature black seeds. Hair peony (var.pilosa) on the back of the leaf, hair on the back of the leaf (P.obovata) which has hair on the back of the leaf, long pistil grows dry and red flowers, hairless on the back of the leaf It is called folk acid peony (povar.glabra). Roots are used for analgesia, myalgia and women's diseases. It is distributed in Korea, Japan, China and Sakhalin Island. It's a bit dry, slightly bitter, bitter and slightly poisonous. It removes blood, smoothes blood vessels, relieves the inside, scatters bad blood, cuts off carbuncles, and abdominal pain. It is a medicine that stops and can eliminate blood and pus. It is mainly used for all illnesses of women, postpartum symptoms and menstruation, and it is used for bleeding with long winds, larvae, insoles, back wounds, redness of eyes, and fleshy eyes, and brightening eyes. (Herb). In the roots, active ingredients such as paeoniflorin, peonol, peonin, benzoic acid, 1.07%, essential oils, fatty oils, resins, tannins, and organic beta-sitosterol (β-sitosterol) And triterpenoids (herbology, book publishing company, P246-246, 2008).

Cnidium officinale Makino (Cnidium officinale Makino) is a dicotyledonous plant and is a perennial plant of the genus Apanaceae. It is native to China and grown as a medicinal plant. It is 30 ~ 60cm high, hollow, and its branches diverge somewhat. The leaves are alternated, 2 times, 3 fluttering leaves, and the forked pieces are egg-shaped lanceolate with somewhat deep serrations. Root leaves and lower leaves have long petioles and the lower part is inverted to cover the stem. Flowers blossom in August, white, multi-colored inflorescences. Petals 5, dried inwards, 5 stamens, 1 pistil. Guns and rifle guns are 5-6 pieces each. Fruits are open but not mature. Between nodes in the ground, it looks like a lump 5-10 cm long and 3-5 cm in diameter and has a strong fragrance. The main components include essential oils such as nydilide, ligustilide, neodinilide, butylphthalide and sedanoic acid. In oriental medicine, root stem is effective for soothing, analgesic, and tonic, and is used for headache and anemia (encyclopedia). It is also used as a treatment for poor blood circulation and postmenopausal abdominal pain in women (primary gangmok, book publishing Younglimsa, p44-448, 2008).

Angelica gigas Nakai is a Korean donkey native to Korea. The effect of Angelica is the blood production (보 作用) to produce blood when there is insufficient blood. Chinese donkeys and why donkeys made from the roots of the donkey is excellent in blood work. But donkey, made from the root of the true donkey is better than the blood-forming action of blood circulation (活血 作用) is more effective, and the anti-cancer effect and blood pressure lowering effect (encyclopedia). Major components include the petroleum butylidene phthalide (herbaceous wood, Younglim Publishing Co., p44-448, 2008).

Fenugreek (Trigonella foenum-graecum) is a perennial herb that grows up to about 50cm in height. Leaves are bilobal (leaves), consisting of 3 small leaves. Yellowish navy blue flowers bloom from June to August. By cultivating, insects help pollination. A pod-shaped fruit opens in August-September and contains 10-20 seeds in the pod.

Fenugreek seeds are usually dried in the sun and medicated. Seeds contain a very small amount of essential oils, which contain about 40 components: different types of alkaloids, proteins and fats. Because of its warm nature and no poison, it has been used to treat bladder and kidney disease in Africa, the Middle East, and India, and has been used to treat people with cold sweat or stomach. Today, it is effective in maintaining the balance between blood sugar and insulin in the body, and is known to be effective in controlling weight (encyclopedia). Major ingredients include alkaloids such as gentianine, carpaine, choline and trigonelline.

Presser foot grass (Pyrola japonica) is an evergreen perennial herb that grows in the forest. It is about 26cm high. Root stems spread sideways. The stalk is straight and the leaves are 1-8 in the base, round or wide oval, 4-7cm long, 2.5-4.5cm long. Petiole purple with petioles but leaf veins are light green with shallow teeth on edges. Petiole 3-8cm long. Flowers bloom in June-July, yellowish white or white, with 5-12 dogs facing down. Corolla is wide oval, divided into 5 branches. There are 10 surgeries and 1 style. The ovary is flat and the calyx is divided into 5 branches, but the base is attached. Fruits are capsules, flat and ripe in brown in September. It is 7-8 mm in diameter. In one shot, the stem and leaves are prescribed for proteinuria and the juice is applied when poisoned. It is distributed in Korea (Jeonbuk, Gyeongnam, Gyeongbuk, Gangwon, Gyeonggi, Pyeongbuk, Hamnam), Japan, Taiwan, China, and Heilong River.

Chundalis turtschaninovii is a tuber of perennial herbaceous and perennial herbaceous plants belonging to the poppy family. It grows in the humid places of the foothills. Tubers are about 1 cm in diameter, and stems grow about 20 cm. At the bottom, one leaf, like a paw, hangs there. The leaves are alternate, the petiole is long, and is divided one by two three times. Branches are obovate, the upper part is deeply or angularly divided, serrated at the edge, and the back is white. Flowers blossom in April, pale reddish purple, 5-10 in total. Corolla is about 2.5cm long, the back is honey bag, and the front is wide spread. The main ingredients are about 10 alkaloids, corydaline, tetrahydropalmatiine, and protopine.

The present inventors have studied to develop an effective, no side effect and safe oral physiological impurity improvers that the plant extract composition containing the earl, cheonggung, true donkey, fenugreek, presser foot grass, Hyunho color is excellent in improving the physiological impurity The present invention has been completed.

The technical problem to be solved by the present invention is to provide a plant extract composition for improving menstrual impurities.

The present invention provides a physiological impurity-improving plant extract composition comprising the earl, cheonggung, true donkey, fenugreek, presser foot grass, Hyunho color.

Paeonia (paeonia lactiflora pall) refers to the root of the peony, the peony extract using a known method, that is, using a solvent, such as a mixture of water and ethanol, it can be used by extracting the hot water to extract useful components from plants.

The uterus (Cnidium officinale Makino) uses the root of the uterus, and can use the Angelica polymorpha Maximowicz and the Chinese native tiger (Ligusticum chuanxiong Hort). As the extract of the uterus, a well-known method, that is, a solvent mixed with water and ethanol, etc. may be used, and one extracted with hot water or the like extracting a useful component from a plant may be used.

Angelica gigas Nakai is a perennial herb belonging to the Araaceae family, and it refers to the donkey that grows in Korea and means the root of the true donkey. Angelica gigas extract using a known method, that is, a solvent mixed with water and ethanol, and the like extracted from the plant with useful water may be used.

Fenugreek (Trigonella foenum-graecum) means the seed of the herb belonging to the fenugreek, and the extract uses a known method, that is, a solvent mixed with water and ethanol.

Presser foot pool (Pyrola japonica) means a herb belonging to the presser foot pool, and the extract is a known method, that is, using a solvent, such as a mixture of water and ethanol, and extracted with hot water to extract useful components from plants.

Corydalis turtschaninovii The tuber belonging to Corydalis, which is removed from the shell, washed, and put in a water bath. Stir until the white core is gone and becomes yellow, then use dry one. The extract may be a known method, that is, a solvent in which water and ethanol are mixed, and the like, which may be extracted with hot water or the like to extract useful components from plants.

The plant extract composition for physiological irregularity improving agent of the present invention may be Baekjak, Cheongung, Sesame Angelica, 50-70% by weight, fenugreek, presser foot paste, and calendula color of 30-50% by weight. Baekjak, Cheonggung, Charm Angelica, Presser Foot Paste and Corydalis Extract Composition are the most excellent in the weight improvement effect.

Extraction composition for improving physiological impurity of the present invention is not limited to the formulation can be prepared by selecting from solutions, suspensions, gels, tablets, rings.

The dosage form of the plant extract composition for improving menstrual impurities is limited to oral use. That is, external preparations or injectable injectable drugs are excluded.

The plant extract composition of the present invention has an advantage of improving physiological impurity and having a great satisfaction of users.

Hereinafter, the present invention will be described in more detail through Examples, Examples. However, this is intended to explain the invention and the present invention is not limited by these implementations.

1) Earl of Peony, Cheongung, Charm Angelica, Fenugreek, Presser Foot Paste, Corydalis

Dried Peony, Cheongung, Chardonnay, Fenugreek and Hyunho-color were purchased commercially, and the presser foot grass was taken from the mountainside near Namyangju, washed well and dried.

2) Preparation of extraction solvent: The mixing ratio of water and alcohol alcohol was mixed 1: 4 and used as an extraction solvent.

3) Extraction Preparation

Count, Chekung, Dongguk, Fenugreek, Fenugreek, Presser foot grass, Hyunho-colored herbs and solvents were added to the extractor in a 1: 5 ratio, and extracted at 65 ° C for 24 hours and then heated to 120 ° C for 10 hours using steam extraction. An extract was prepared.

4) Mixed Extract Manufacturer

As shown in <Table 1> a) Equivalent mixture of Baekjak, Cheongung, and Angelica extract (T1) b) Equal mixture of fenugreek, presser foot paste, corydalis color, and c) T1: T2 = 4: 1 (T3) , D) T1: T2 = 3: 2 (T4), E) T1: T2 = 2: 1 (T5), T1: T2 = 1: 1 (T6) Vacuum packed in polyethylene film.

Table 1 Mixing Ratio by Drug

Note: numbers; Mixing ratio. (%); Composition weight percentage

<Example 1>

In order to test the formulation for improving the physiological impurity of female life, it was prepared as shown in <Table 2>.

<Table 2> Symptom Improvement Effects by Test Preparation

Note: (/): Improved number /% tested

The study group was divided into three groups: women with periods of at least three months of interruption, periods with very low periods or irregular periods, irregular periods, and severe periods. 226 were selected and tested. Subject age ranged from 20s to early 50s. The test agent was used by dividing into T1, T2, T3, T4, T5, T6 as shown in <Table 1>.

The test results shown in the above <Table 2> indicate the following facts. Firstly, the same amount mixture (T1) of Count, Cheongung, and Angelica extract showed that the effect was not large, 16-50% by weight in all groups. Second, fenugreek, presser foot paste, and sinusoidal equivalent mixture (T2) showed 60% by weight in improving menstrual cramps, while the other group showed 20-26% by weight. As a result, fenugreek, presser foot paste, and sinusoidal equivalent mixture (T2) are shown to be effective in improving pain. Third, T3, a mixture of T1 and T2 extract mixtures in a 4: 1 ratio, showed a low effect of 40-60% by weight in improving dysmenorrhea. Fourth, T4, a mixture of T1 and T2 extract mixtures in a 3: 2 ratio, showed a very good effect (60-90%) in all items before the test and showed some effects on pain relief as well as improving physiological control. Fifth, T5, which is a mixture of T1 and T2 extract mixtures in a 2: 1 ratio, showed a relatively low effect of 40% by weight on menstrual pain relief, while a 70-80% by weight improvement in physiological control. Sixth, T1, a mixture of T1 and T2 extract mixtures in a 1: 1 ratio, showed a relatively high effect of improving physiological control at 50-60% by weight, while having a low effect of 30% by weight of menstrual pain. Seemed. Comprehensive analysis of the results from the trial showed that Baekjak, Cheongung, and Angelica extracts were effective in regulating women's physiology, while fenugreek, presser foot paste, and hyacinth extracts were effective in relieving menstrual pain. As shown in the results, the composition ratio of the complex extract mixture of the two groups was 50-70 wt% for Baekjak, Cheongung, and Angelica extract mixture, and 30-50 wt% for Fenugreek, presser foot paste, and corydalis extract mixture. Among them, the ratio of T4 preparation (T1: T2 = 3: 2) showed the highest effect. Therefore, it was confirmed that Baekjak, Cheonggung, Angelica, Fenugreek, presser foot paste, Hyunho-colored composition is excellent composition for improving female physiological control.

Claims (3)

Extract composition for improving women's menstrual impurities from Count, Cheongung, Angelica, Fenugreek, Presser foot grass and Hyunho color. The composition according to claim 1, wherein 50 to 70% by weight of Paekak, Cheongung, and Angelica extract are mixed with 30 to 50% by weight of fenugreek, presser foot paste, and corydalis extract. The composition is a plant extract composition having a formulation selected from solution, suspension, emulsion, gel, tablet, ring