KR20100090737A - 고 함량의 활성형 플라보노이드 화합물의 제조방법 및 이로부터 퀘르세틴의 간편 신속 분리 방법 - Google Patents
고 함량의 활성형 플라보노이드 화합물의 제조방법 및 이로부터 퀘르세틴의 간편 신속 분리 방법 Download PDFInfo
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- KR20100090737A KR20100090737A KR1020090009988A KR20090009988A KR20100090737A KR 20100090737 A KR20100090737 A KR 20100090737A KR 1020090009988 A KR1020090009988 A KR 1020090009988A KR 20090009988 A KR20090009988 A KR 20090009988A KR 20100090737 A KR20100090737 A KR 20100090737A
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
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- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase
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- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01006—Endo-1,3(4)-beta-glucanase (3.2.1.6)
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- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01008—Endo-1,4-beta-xylanase (3.2.1.8)
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Abstract
Description
Claims (5)
- 삼백초에 당분해 효소를 첨가하여 글리아콘 형태의 비활성 플라보노이드 화합물을 아글라이콘 형태의 활성형 플라보노이드 화합물로 전환시킴으로서 활성형 플라보노이드 화합물의 함량이 증가된 삼백초 조성물을 제조하는 것을 특징으로 하는 고 함량의 활성형 플라보노이드 화합물의 제조방법.
- 제1항에 있어서,상기 당분해 효소는 셀룰라아제, 베타글루카네제 및 자일라제를 포함하는 비스코자임(viscozyme)을 이용하는 것을 특징으로 하는 고 함량의 활성형 플라보노이드 화합물의 제조방법.
- 제1항에 있어서,상기 첨가되는 당분해 효소는 농도 0.25ml/g, 효소처리 온도 35℃, 효소처리 시간 12시간을 일정하게 유지하는 것을 특징으로 하는 고 함량의 활성형 플라보노이드 화합물의 제조방법.
- 제1항에 있어서,상기 플라보노이드 화합물은 적어도 퀘르세틴을 함유하는 것을 특징으로 하는 고 함량의 활성형 플라보노이드 화합물의 제조방법.
- 상기 제1항에 의해 제조된 활성형 플라보노이드 화합물을 이용하여 실리카겔 칼럼 크로마토그래피 및 ODS 컬럼 크로마토그래피로 퀘르세틴을 신속하게 분리하는 것을 특징으로 하는 고 함량의 활성형 플라보노이드 화합물로부터 퀘르세틴의 간편 신속 분리 방법.
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WO2021256865A1 (ko) * | 2020-06-17 | 2021-12-23 | 다당앤바이오 주식회사 | 삼백초 분획물을 포함하는 약학 조성물 및 이의 제조 방법 |
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US5827682A (en) | 1995-06-07 | 1998-10-27 | Protein Technologies International, Inc. | Two-step conversion of vegetable protein isoflavone conjugates to aglucones |
AUPQ504300A0 (en) * | 2000-01-11 | 2000-02-03 | Biorex Health Limited | Extraction of flavonoids |
US20040071685A1 (en) | 2002-10-09 | 2004-04-15 | Devin Houston | Compositions and methods for increasing the bioavailability of plant polyphenols |
KR20050076225A (ko) * | 2004-01-20 | 2005-07-26 | 학교법인 인제학원 | 항산화 및 항염증 활성을 갖는 삼백초 추출물을 포함하는조성물 |
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WO2021256865A1 (ko) * | 2020-06-17 | 2021-12-23 | 다당앤바이오 주식회사 | 삼백초 분획물을 포함하는 약학 조성물 및 이의 제조 방법 |
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