KR20100038578A - Cosmetic formulations of granule type and preparation method of the same - Google Patents

Abstract

PURPOSE: A granular cosmetic formulation and a method for manufacturing the same are provided to stabilize unstable active ingredient and inform dissolution time of a soluble active ingredient to consumers. CONSTITUTION: A method for manufacturing a granular cosmetic formulation comprises: a step of mixing soluble active ingredient of powder type and thickener to obtain mixture powder; a step of dissolving the thickener in a solvent; and a step of forming granular particle by spraying the thickener solution to the mixture powder. The soluble active ingredient is arbutin, kojic acid, adenosine, coenzyme Q10, vitamin C, or glutathione. The thickener is xanthan gum and poly-gamma-glutamic acid. A granular cosmetic formulation contains soluble active 10.0-70.0 weight% of ingredient, 5.0-50.0 weight% of thickener, and 5.0-40.0 weight% of excipient.

Description

Granular cosmetic formulations and manufacturing method thereof {Cosmetic Formulations of Granule Type and Preparation Method of the Same}

It relates to a granular cosmetic formulation of anhydrous formulations and a method for producing the same.

In the case of a water-soluble active ingredient, for example, vitamin C, there is a problem that discoloration occurs in the environment in which water is present, and destabilizes to lower the titer. In order to compensate for this problem, a method of stabilizing the emulsion in the form of vitamin C on the polyol mainly by using a polyol in silicone (P / S) formulation, or by increasing the vitamin C in the oil.

However, when vitamin C is added to the polyol, although vitamin C is stabilized to some extent, discoloration occurs at a high temperature due to moisture contained in the polyol. In particular, there is a problem that discoloration may occur due to the hygroscopicity of the polyol. In addition, in the case of increasing the mixing of vitamin C in the oil, it is possible to stabilize the vitamin C by blocking the water supply from the outside, but there is a disadvantage that the feeling as a cosmetic becomes very bad.

Another stabilization method is a method of mixing various components in powder form and mixing them with the essence solution and shaking them to use them. However, this method may cause a problem that becomes undesirable for dissolution because of a cakeing phenomenon, that is, lumps and hardens during long-term storage in a simple mixed state of the raw materials.

An object of one embodiment of the present invention is to provide a method for producing a granular cosmetic formulation.

It is an object of another embodiment of the present invention to provide a granular cosmetic formulation of anhydrous formulation.

The present invention relates to a granular cosmetic formulation and a method for producing the same. In more detail, the production method comprises the steps of: (a) mixing a water-soluble active ingredient and a thickener to prepare a mixed powder; (b) dissolving the thickener in a solvent to prepare a thickener solution; And (c) forming a granular particle by rotating at 5 to 200 rpm while spraying the thickener solution of step (b) to the mixed powder of step (a).

In addition, the granular cosmetic formulation contains a water-soluble active ingredient and a thickener, the particle size of the granules is 300 to 1000 ㎛, characterized in that the density of the granules is 0.3 to 0.4 g / cm ³ .

The granular cosmetic formulation according to the present invention is capable of stabilizing an unstable water-soluble active ingredient in the form of water-free particles, and visually gives the consumer a point of dissolution of the water-soluble active ingredient contained in the granule particles by an incremental phenomenon. In addition to being informed, it can be used as a product that can visually differentiate.

Method for producing a granular cosmetic formulation according to an embodiment of the present invention,

(a) mixing a water-soluble active ingredient in a powder state and a thickener to prepare a mixed powder;

(b) dissolving the thickener in a solvent to prepare a thickener solution; And

(c) forming a granular particle by rotating at 5 to 200 rpm while spraying the thickener solution of step (b) to the mixed powder of step (a).

The granular cosmetic formulation of the anhydrous formulation according to the production method of the present invention can prevent the phenomenon of caking, that is, agglomeration and hardening, which may occur when the cosmetic raw material is stored for a long time in a simple mixed state. In addition, when using the granular cosmetic formulation, it is made to increase while dissolving in water, through which it is possible to implement a nutritious properties, there is an advantage that it is convenient to use because it does not flow.

Granular particles produced by the method according to the invention, the particle size of the granules in one embodiment may be 300 to 1000 ㎛, in another embodiment the density of the granules may be 0.3 to 0.4 g / cm ³ have. The size and density of the granular particles are indicative of a range for optimizing solubility and usability in water.

In one embodiment, the water soluble active ingredient comprises at least one selected from the group consisting of arbutin, kojic acid, adenosine, coenzyme Q10, vitamin C and glutathione. The water-soluble active ingredient, depending on the purpose to be implemented, various cosmetic raw materials can be applied without limitation.

Coenzyme Q10 used in the present invention has a structure in which isoprenoid side branches are repeatedly attached to benzoquinone. In nature there are repeating forms of 6 to 12 isoprenoid branchings, the most common of which is coenzyme Q10 with 10 isoprenoid branchings. The chemical name of Coinzyme Q10 is 2,3-dimethoxy-5-methyl-6decaprenyl-1,4-benzo-quinone.

In one embodiment, the thickener may be at least one selected from the group consisting of Xanthan Gum and Poly-γ-glutamic acid. The thickener to be mixed in the step (a) stabilizes the unstable water-soluble active ingredient, and when dissolved in water or an aqueous solution, the thickener is used to form a gel or similar properties. In addition, in the step (b), a thickener solution is prepared, and the granular formulation is formed by spraying and mixing the mixed solution in the step (a).

In another embodiment, the content of the water-soluble active ingredient, based on the total weight of the cosmetic formulation, the content of the water-soluble active ingredient is 10.0 to 70.0% by weight, more specifically may be 20.0 to 50.0% by weight. In addition, the content of the thickener, based on the total weight of the cosmetic formulation, may be 5.0 to 50.0% by weight, more specifically 10.0 to 40.0% by weight. The content of the water-soluble active ingredient and the thickener mentioned above is for forming a stabilized formulation of the cosmetic formulation and optimizing solubility in aqueous solution, etc., to increase convenience and usability.

In one embodiment of the present invention, prior to the step (a), may further comprise a pre-treatment process for processing the particle size of the water-soluble active ingredient and the thickener to 800 or more fine powder. This is a process of processing the raw material in the form of fine powder, which leads to uniform mixing between the raw materials.

Also, in the step (a), an excipient may be further added. In one embodiment, the content of the excipient may be 5.0 to 50.0% by weight, more specifically 10.0 to 40.0% by weight based on the total weight of the cosmetic formulation. The type of the excipient is not particularly limited and may be mannitol.

In the step (c), the prepared thickener solution is mixed while spraying the mixed powder of the step (a). The thickener solution acts as a binder to form granular particles. In one embodiment, the thickener solution may be prepared by dissolving xanthan gum or polygammaglutamic acid in water or an aqueous solution to a concentration of 0.5 to 2.0 wt% based on the weight of the thickener solution. In another embodiment, the amount of the thickener solution added may be 0.2 to 1.2 wt% based on the total weight of the cosmetic formulation.

In addition, the step (c) is to form granular particles while rotating at a low rotational speed. In one embodiment, the step (c) is to form granular particles while rotating at 5 to 200 rpm, more specifically at 50 to 80 rpm. The process is similar to the general pelletization process, but in order to allow the granulated active ingredient to dissolve well in water, it forms granular particles at a relatively low rotational speed. In the process of particle formation, the higher the rotation speed, the higher the density of the components, and the lower the solubility in water or aqueous solution.

The present invention also provides granular cosmetic formulations containing a water-soluble active ingredient and a thickener. Since the granular cosmetic formulation according to the present invention has a very fast dissolution rate in water, when dissolved in water at the time of use, an increase in viscosity is achieved and a nutritious property can be realized. Therefore, the granular cosmetic formulation according to the present invention can be implemented as a product in the form of dissolving in water when used and applied to the skin. In one embodiment, the granular cosmetic formulation may be a formulation showing a viscosity of 3000 to 5000 g / cm · s when dissolved in 20 ° C water at a concentration of 0.5 g / aqueous solution (water) 5 g.

In one embodiment, the granular particles according to the present invention may have a solubility in water of 20 ° C. from 1 to 70. The granular particles have a very good solubility in water and when the water is dissolved in water, a thickening occurs, and when the solubility exceeds 60, gelation occurs.

In one embodiment the particle size of the granules may be 300 to 1000 ㎛, in another embodiment the density of the granules may be 0.3 to 0.4 g / cm ³ . The size and density of the granular particles are indicative of a range for optimizing solubility and usability in water.

In one embodiment, the water soluble active ingredient comprises at least one selected from the group consisting of arbutin, kojic acid, adenosine, coenzyme Q10, vitamin C and glutathione. The water-soluble active ingredient, depending on the purpose to be implemented, various cosmetic raw materials can be applied without particular limitation.

In one embodiment, the thickener may be one or more selected from the group consisting of Xanthan Gum and Poly-γ-glutamic acid. The thickener stabilizes an unstable water-soluble active ingredient, and when dissolved in water or an aqueous solution, the thickener is used to form a gel or a similar feature.

In another embodiment, the content of the water-soluble active ingredient, based on the total weight of the cosmetic formulation, the content of the water-soluble active ingredient is 10.0 to 70.0% by weight, more specifically may be 20.0 to 50.0% by weight. In addition, the content of the thickener, based on the total weight of the cosmetic formulation, may be 5.0 to 50.0% by weight, more specifically 10.0 to 40.0% by weight. The content of the water-soluble active ingredient and the thickener mentioned above is for forming a stabilized formulation of the cosmetic formulation and optimizing solubility in aqueous solution, etc., to increase convenience and usability.

In addition, the granular cosmetic formulation may further include an excipient. In one embodiment, the content of the excipient may be 5.0 to 50.0% by weight, more specifically 10.0 to 40.0% by weight based on the total weight of the cosmetic formulation. The type of the excipient is not particularly limited and may be mannitol.

Hereinafter, the present invention will be described in more detail through preferred embodiments of the present invention, but the following examples and the like are intended to confirm the effects of the present invention by way of example, and the scope of the present invention is not limited thereto.

[Examples 1 and 2 and Comparative Examples 1 and 2] Preparation of Granular Particles

The formulations below are all anhydrous formulations.

Raw material name (content: weight%) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Arbutin 5.0 5.0 5.0 5.0 Kojic acid 2.0 5.0 2.0 5.0 Adenosine 1.0 5.0 1.0 5.0 Coenzyme Q10 2.0 2.0 2.0 2.0 Vitamin C (ascorbic acid) 30.0 20.0 30.0 20.0 Glutathione 5.0 3.0 5.0 3.0 Aminocoat 5.0 5.0 5.0 5.0 N-acetyl-D-Glucosamine 5.0 5.0 5.0 5.0 Trehalose 5.0 5.0 5.0 5.0 Polygamma glutamic acid 5.0 5.0 5.0 5.0 Xanthan Gum 5.0 20.0 5.0 20.0 D-Mannitol 30.0 20.0 30.0 20.0 Total 100.0 100.0 100.0 100.0

<Examples 1 and 2>

1) Raw materials according to Table 1 were identified and pretreated. Through the pretreatment process, the particle size of the raw material used a powder of fine powder of 80 mesh or more. Aminocoat and trehalose were used after checking the particle size after the grinding process.

2) Raw material (Arbutin / Kojic acid / Adenosine / Coenzyme Q10 / Ascorbic acid / Glutathion / Aminocoat / N-Acetyl-D-Glucosamine / Trehalose / Polygamma glutamic acid / Xanthan Gum / D-mannitol in the main rotor chamber) ) Was added uniformly according to the composition ratio of Table 1.

3) 0.5% by weight of xanthan gum was dissolved in purified water to prepare a 0.8% aqueous solution.

4) The rotor chamber was rotated while nozzle spraying the xanthan gum aqueous solution prepared in 3) into the rotor chamber. The rotation speed of the rotor chamber was maintained at 70 rpm.

5) It was confirmed that before the raw material was completely pelletized, it formed granular particles.

<Comparative Examples 1 and 2>

1) Check the raw material according to Table 1, and did not undergo a separate pretreatment or particle size verification process.

2) Powder raw materials (Aminocoat / N-Acetyl-D-Glucosamine / Trehalose / Polygamma glutamic acid / XanthanGum / D-mannitol) were uniformly mixed according to the composition ratio of Table 1.

3) The mixed powder was pulverized using a mixer to obtain fine particles.

Experimental Example 1 Solubility Comparison

The particles prepared in Examples 1 and 2 and Comparative Examples 1 and 2 were added to purified water to observe the presence of dissolution. In the case of Examples 1 and 2, 0.5 g of granular particles were used. The observation results are shown in Table 2 below.

Observation item Example 1 Example 2 Comparative Example 1 Comparative Example 2 Dissolution O O X X O: Yes, X: No

Referring to Table 2, it could be observed that in Examples 1 and 2, there was a dissolution phenomenon, but in Comparative Examples 1 and 2, dissolution phenomenon could not be observed.

Experimental Example 2 Residue After Dissolution

The particles prepared in Examples 1 and 2 and Comparative Examples 1 and 2 were dissolved in an aqueous solution by the same method as Experimental Example 1. 0.5 g of each of the samples of Examples 1 and 2 and Comparative Examples 1 and 2 were taken and added to 5 g of the aqueous solution. In each case, the dissolution time and the number of shakes during dissolution were different.

First, spontaneous dissolution occurred in each state of the samples in the aqueous phase solution without a separate stirring process. The time taken for the dissolution to complete was measured. Next, while each sample was put in the aqueous solution, the number of shaking was measured slowly by shaking up and down by hand until dissolution was completed. After the dissolution process was completed for each sample, the presence or absence of residues was observed. The observation results are shown in Table 3 below.

Observation item Example 1 Example 2 Comparative Example 1 Comparative Example 2 Dissolution time 1 minute 20 seconds 1 minute 40 seconds 40 minutes 20 seconds 40 minutes 40 seconds The number of times to shake to dissolve 5 times 9th 100 times 100 times Presence of residue after melting X X O O O: Yes, X: No

Referring to Table 3 above, when left unstirred, Examples 1 and 2 spontaneously dissolved within a relatively short time within 2 minutes. However, Comparative Examples 1 and 2 took a very long time, it can be confirmed that the residue remains even after 4 minutes or more. In addition, even when it was made to shake by hand, it turns out that compared with Examples 1 and 2, the number of shakings was comparatively large compared with Examples 1 and 2.

[Experimental Example 3] Experiment for the presence of incremental phenomenon

The particles prepared in Examples 1 and 2 and Comparative Examples 1 and 2 were dissolved in an aqueous solution in the same manner as in Experimental Example 1, and the presence or absence of a gradual phenomenon was observed.

0.5 g of each of the samples of Examples 1 and 2 and Comparative Examples 1 and 2 were taken and added to 5 g of an aqueous solution. After each sample was completely dissolved, the presence or absence of the phenomenon was observed, the results are shown in Table 4 below.

Observation item Example 1 Example 2 Comparative Example 1 Comparative Example 2 Incremental phenomenon O O X X O: Yes, X: No

Referring to Table 4, in Examples 1 and 2 it can be observed that there is an increase, but in Comparative Examples 1 and 2 it was not possible to observe the increase.

[Experimental Example 4]

The presence or absence of the residue after dissolution according to the weight of the sample prepared in Example 1 was observed. Each sample was added to 5 g of aqueous solution, varying the weight of the granular particles of Example 1 at 0.5, 1.0 and 1.5 g. The time taken for the added samples to dissolve and the presence of residues were observed. The observation results are shown in Table 5 below.

Observation item Granule Weight of Example 1 0.5 g 1.0 g 1.5 g Dissolution time 1 minute 40 seconds 2 minutes 10 seconds 2 minutes 30 seconds Presence of residue after melting X X X O: Yes, X: No

Referring to Table 5 above, when the weight of the granular particles of Example 1 was increased by 2 times and 3 times, there was a slight difference in time of dissolution, but it was confirmed that there was no residue after dissolution. Therefore, it is possible to increase the concentration of the active ingredient by increasing the weight of the granules, but it can be seen that the dissolution time becomes longer as the concentration increases, but there is no problem of remaining residue.

Experimental Example 5 Comparison of Visual Differentiation and Convenience in Using Cosmetic Compositions

A cosmetic composition was prepared using the particles prepared in Example 1 and Comparative Example 1. Example 1 was made of particles made of 0.5 g of granules, and the cosmetic composition was prepared by putting 0.5 g of the sample in 5.0 g of an aqueous solution in both Example 1 and Comparative Example 1.

For each cosmetic composition, 30 subjects underwent visual discrimination and ease of use. The results for visual discrimination are shown in Table 6, and the results for convenience in use are shown in Table 7. Each evaluation was performed by relative evaluation.

Observation item Responses Example 1 Comparative Example 1 There is visual differentiation 27 One No visual differentiation One 26 Don't know / no response 2 3

Observation item Responses Example 1 Comparative Example 1 It is convenient 19 2 Uncomfortable 4 23 Don't know / no response 7 5

Referring to Tables 6 and 7, in Example 1, compared with Comparative Example 1, 90% of respondents have visual differentiation, and 63% of respondents indicated that they were easy to use. Therefore, it was confirmed that the case of Example 1 of the particle type in the form of granules was visually different and convenient to use.

Claims (19)

(a) mixing a water-soluble active ingredient in a powder state and a thickener to prepare a mixed powder; (b) dissolving the thickener in a solvent to prepare a thickener solution; And (c) granular cosmetic formulation comprising the step of forming granular particles by rotating at 5 to 200 rpm while spraying the thickener solution of step (b) to the mixed powder of step (a) Manufacturing method. The method of claim 1, Method for producing a granular cosmetic formulation, characterized in that the density of the granular particles formed through the step (c) is 0.3 to 0.4 g / cm ³ . The method of claim 1, The water-soluble active ingredient is arbutin, kojic acid, adenosine, coenzyme Q10, vitamin C and glutathione manufacturing method of a granular cosmetic formulation, characterized in that at least one selected from the group consisting of. The method of claim 1, The thickener is a method for producing a granular cosmetic formulation, characterized in that any one or more selected from Xanthan Gum and poly-gamma glutamic acid (Poly-γ-glutamic acid). The method of claim 1, In the granular cosmetic formulation, the content of the water-soluble active ingredient is 10.0 to 70.0% by weight based on the total weight of the cosmetic, and the content of the thickener is 5.0 to 50.0% by weight of the granular cosmetic formulation Manufacturing method. The method of claim 1, Before the step (a), the method for producing a granular cosmetic formulation, characterized in that it further comprises a pre-treatment step of processing the water-soluble active ingredient and the thickener into fine powder of 800 mesh or more in particle size. The method of claim 1, In the step (a), the method of producing a granular cosmetic formulation, characterized in that further adding a powdered excipient. The method of claim 7, wherein The excipient content is, based on the total weight of the cosmetic formulation, a method for producing a granular cosmetic formulation, characterized in that 5.0 to 50.0% by weight. The method of claim 7, wherein The excipient is mannitol (mannitol) characterized in that the method for producing a granular cosmetic formulation. The method of claim 1, The concentration of the thickener solution of the step (b) is 0.5 to 2.0% by weight based on the weight of the thickener solution, the method for producing a granular cosmetic formulation. A granular formulation containing a water-soluble active ingredient and a thickening agent, characterized in that the solubility in water at 20 ℃ 1 to 70 characterized in that the granular cosmetic formulation. The method of claim 11, The particle size of the granules is 300 to 1000 ㎛, granule density of 0.3 to 0.4 g / cm ³ characterized in that the granular cosmetic formulation. The method of claim 11, The water-soluble active ingredient is arbutin, kojic acid, adenosine, coenzyme Q10, vitamin C and glutathione granular cosmetic formulation, characterized in that at least one selected from the group consisting of. The method of claim 11, The thickener is a granular cosmetic formulation, characterized in that any one or more selected from the group consisting of Xanthan Gum and poly-gamma glutamic acid (Poly-γ-glutamic acid). The method of claim 11, The content of the water-soluble active ingredient, based on the total weight of the cosmetic formulation, granular cosmetic formulation, characterized in that 10.0 to 70.0% by weight. The method of claim 11, The content of the thickener is a granular cosmetic formulation, characterized in that 5.0 to 50.0% by weight, based on the total weight of the composition. The method of claim 11, The cosmetic formulation is a granular cosmetic formulation, characterized in that it further comprises 5.0 to 40.0% by weight of the excipient based on the total weight of the composition. The method according to any one of claims 11 to 17, The granular cosmetic formulation is a granular cosmetic formulation, characterized in that the formulation is increased in viscosity when dissolved in water. The method of claim 18, The granular cosmetic formulation is a granular cosmetic formulation, characterized in that the viscosity of 3000 to 5000 g / cm · s when dissolved in 20 ° C water at a concentration of 0.5 g / 5g aqueous solution.