KR20090108848A - The composition for the treatement of atopy - Google Patents

Abstract

PURPOSE: A composition for treating atopy is provided to effectively treat and prevent atopy without side effects. CONSTITUTION: A composition for treating atopy comprises 0.01-20 ppm of epidermal growth factor or fibroblast growth factor, 1.0-5.0 weight% of vegetable amino acid peptide, 0.1-3.0 weight% of polyglutamic acid, 0.01-1.0 weight% of ceramide, 0.1-3.0 weight% of ubiquinone, 0.1-3.0 weight% of DNA-gel, and 1.0-5.0 weight% of cocoa butter.

Description

The composition for the treatement of atopy

The present invention relates to a composition for treating atopic dermatitis, and more specifically, epidermal growth factor and fibroblast growth factor are added in an amount of 0.01 to 20 ppm with respect to the whole composition, and the vegetable amino acid peptide 1.0 -5.0 wt%, polyglutamic acid 0.1-3.0 wt%, ceramide 0.01-1.0 wt%, ubiquinone (coenzyme Q10) 0.1-3.0 wt%, DNA-gel 0.1-3.0 It is related with the composition which can obtain the outstanding effect to atopy treatment by containing by weight and 1.0-5.0 weight% of cocoa butter.

In general, a constitution that is easy to cause an allergic reaction is called atopic constitution, and a skin disease occurring in such a person is called atopic dermatitis, and these patients are prone to allergic infections and asthma, and thus cause allergies in indoor environments such as pets and flower arrangements. Possible factors should be avoided.

In addition, in children, the symptoms may worsen due to food allergies, so pay attention to food choices, and it takes a lot of infancy, and about 20% of infants are reported to have atopic dermatitis, most of which are 16 ~ If it disappears before 18 months but does not heal, it continues to occur and continues to cause severe dermatitis.

The root cause is allergic constitution, you should pay attention to the acquired conditions that cause it, and if you eat foods that have a lot of dust or scattered animal hair or antigenic foods, it is easy to cause allergies. Even clothes and cosmetics contain allergens.

In infants, a rash appears on the chest or abdomen starting from the face and passes through the stones. Among them, red and thick rashes appear on the knees and the inside, and itching does not go away. .

The characteristic symptoms of atopic dermatitis are itching and severe scratching, and infants often take care of them for no particular reason, frequently relapse with chronic diseases that last for more than 6 weeks, and atopic diseases (asthma, allergic rhinitis) , Atopic dermatitis), characterized by eczema on the folding of the face, arms, and legs, dry skin and skin disease since childhood, well-opened lips, skin on hands, soles or fingers Peeling and cracking As if the neck is black, the nipples are dark or bleeding, as well as the skin around the eyes or under the eyes, and conjunctivitis is more likely to occur.

As a rule, the area in which the rash appears decreases with age, but the stiffness of the skin tends to be worse.

The best way to treat allergies is to stay away from the cause of allergies, and long-term symptomatic treatment is needed, mainly with corticosteroid ointments.

In addition, it is effective to avoid skin irritation, the room temperature should be maintained at 18 ~ 23 ℃, the bath is also recommended to shorten in water of 26 ~ 27 ℃, sunbathing or swimming temporarily worsen symptoms In some cases, it is basically a way to lighten the symptoms of living outside air.

Atopic dermatitis, a representative disease of sensitive and dry skin, is a chronic inflammatory skin lesion characterized by chronic recurrence, characteristic lesion distribution with pruritus (itch) and dryness, and family history of allergy. Disease. General dermatitis can be cured by proper treatment such as steroids in the hospital, but atopic dermatitis is difficult to cure, so proper skin care is often required as a sideline. To date, there is no doubt that atopic dermatitis is one of the causes of the disease in immunological aspects, but the immunological aspects are not enough to explain the various clinical features and symptoms of atopic dermatitis.

It is worth noting that recent studies have described the abnormality of the skin barrier function, which is an inherent function of atopic dermatitis, as one of the important factors, and to understand the characteristics of atopic dermatitis in terms of abnormality of the skin barrier function. In addition, it is necessary to consider the concept of atopic skin care which focuses on the recovery of skin barrier function. Moisturizing and protecting the skin through skin care is very important because atopic skin is susceptible to stimulus from the outside due to abnormal barrier function of the stratum corneum.

As a technique useful for conventional atopy, Korean Laid-Open Patent Publication No. 2005-0072378 discloses atopy containing a plant extract containing 0.1 to 10.0% by weight of a plant extract extracted from baeknyeoncho, Jibuja, Chajeoncho, Yonggyu, Myeongju and Jisil in a general cosmetic composition. A cosmetic composition for skin is disclosed, and Korean Patent No. 0511494 discloses a composition for treating atopic dermatitis containing sewage extract as an active ingredient, and various studies for atopic treatment have been attempted. However, conventional atopy treatments have problems such as unsatisfactory treatment effect and causing many side effects on the human body.

Accordingly, it is an object of the present invention to provide a composition for treating atopic dermatitis, which exhibits an excellent effect on the treatment of atopy without causing side effects on the human body.

In order to achieve the above objects as well as other easily attainable objects, in the present invention, the epidermal growth factor and fibroblast growth factor are added in an amount of 0.01-20 ppm with respect to the whole composition. 1.0 to 5.0% by weight of vegetable amino acid peptide, 0.1 to 3.0% by weight of polyglutamic acid, 0.01 to 1.0% by weight of ceramide, 0.1 to 3.0% by weight of ubiquinone (coenzyme Q10), DNA-gel (gel ) By containing 0.1 to 3.0% by weight and cocoa butter 1.0 to 5.0% by weight, it was possible to obtain excellent effects in the treatment and prevention of atopy.

Atopic dermatitis treatment composition of the present invention is added to the epidermal growth factor (fiidermal growth factor) and fibroblast growth factor (fibroblast growth factor) 0.01 to 20ppm with respect to the total composition, 1.0 to 5.0% by weight of vegetable amino acid peptide, polygle 0.1 to 3.0% by weight of polyglutamic acid, 0.01 to 1.0% by weight of ceramide, 0.1 to 3.0% by weight of ubiquinone (coenzyme Q10), 0.1 to 3.0% by weight of DNA-gel (gel) and 1.0 to 3.0% of cocoa butter The composition containing 5.0% by weight was prepared in various formulations and applied to the site or site where the atopic was likely to occur, thereby obtaining an excellent effect on the treatment and prevention of atopy without causing side effects.

The composition for treating atopic dermatitis according to the present invention is added so that the epidermal growth factor and fibroblast growth factor are 0.01 to 20 ppm relative to the total composition, and 1.0 to 5.0% by weight of the vegetable amino acid peptide. , 0.1 to 3.0% by weight of polyglutamic acid, 0.01 to 1.0% by weight of ceramide, 0.1 to 3.0% by weight of ubiquinone (coenzyme Q10), 0.1 to 3.0% by weight of DNA-gel (gel) and cocoa It is characterized by containing 1.0-5.0 weight% of butter.

Epithelial cell growth factor used in the present invention is a polypeptide having a molecular weight of 6045 having 53 amino acids and 3 disulfide bonds known as eurogastrone, to various cells including epithelial and mesenchymal cells. It promotes mitosis, promotes cell growth, and inhibits gastric acid secretion, which is effective in treating skin or corneal wounds or gastric ulcers, and plays a key role in skin cell angiogenesis and regeneration. Promotes division and growth of keratinocytes to shorten the turnover (Turn over) to strengthen the skin barrier function.

The epithelial growth factor is preferably added so as to be 0.01 to 20ppm with respect to the total composition, when the addition amount is less than 0.01ppm, the effect of addition effect is weak, and when it exceeds 20ppm, the addition synergistic effect is weak and it is not economical. .

On the other hand, the fibroblast growth factor used in the present invention is a group of strong mitosis stimulating factor of heparin binding to both normal gastric fibroblasts and established cell lines, acidic FGF (FGF-1) in the FGF group , Basic FGF (FGF-2), INT-2 (FGF-3), K-FGF / HST (FGF-4), FGF-5, FGF-6, KGF (FGF-7), AIGF (FGF-8) And FGF-9 to FGF-18. All FGFs have two cysteine residues as conservative residues, and their amino acid sequence is 30-50% homologous, and these factors are normal ventral mesoderm-derived and neural toxin-derived cells, induced granulosa cells, and adrenal cortex. Cells, Crondocites, Myoblasts, Corneal and Vascular Endothelial Cells (Bovine or Human), Vascular Smooth Muscle Cells, Lenses, Retina and Prostate Epithelial Cells, Diligent Glial Cells, (Nerve Glia) Astrocytes, Crondocites, Myoblasts and Osteoblasts Mitotic promoters for cells and the like.

Fibroblast growth factor can also be promoted in a dissimilar fashion for many different cell types. These growth factors may promote cell migration to the wound (chemotactic chemotaxis), initiate new blood vessel formation (vasculature), revive and sustain nerves (neurotrophic), regulate endocrine function, express specific cellular proteins, and extracellular matrix Functions to promote or inhibit production and cell survival.

In the present invention, fibroblast growth factor promotes biosynthesis of collagen and elastin in the dermal layer, prevents the occurrence of atopy, and improves the atopy that is in progress, and at the same time promotes angiogenesis of skin cells to promote skin nutrition and elasticity. It serves to strengthen.

The fibroblast growth factor is preferably added so as to be 0.01 to 20ppm with respect to the whole composition, when the addition amount is less than 0.01ppm, the addition effect is weakly expressed, and when it exceeds 20ppm, the addition synergistic effect is weak and it is not economical. .

When the fibroblast growth factor stimulates the fibroblasts in the skin, fibroblasts actively divide and produce collagen, elastin, and hyaluronic acid. Collagen or elastin is a fibrous protein that accounts for most of the dermis. It is responsible for skin elasticity and has a perfect net structure. Between the two fibers, fibers are supplied with sufficient moisture by hyaluronic acid. In addition to restoring the skin to an elastic state and antioxidative action, the active oxygen that causes aging can be prevented, and skin aging can be prevented. It brings moisture and elasticity, and suppresses the production of excess melanin pigment to make the skin white and moist.

Polyglutamic acid (PGA) used in the present invention is an ingredient extracted from soybeans, which plays an excellent role in expressing skin moisturizing effect, and has a moisturizing power of 50 compared to hyaluronic acid used as a conventional moisturizing ingredient. It is preferable to use 0.1-3.0 weight% with respect to the whole composition as having twice or more and 100 times or more moisturizing power compared with collagen.

When the amount of the polyglutamic acid used is less than 0.1% by weight, the addition effect is insignificant, and when it exceeds 3.0% by weight, the addition synergistic effect is insignificant and it is not economical.

In addition, the ceramide used in the present invention belongs to a lipid (lipid), does not dissolve in water, and has a feature that is dissolved in alcohol because spingosine (Sphingosine) and fatty acids are OH-linked, one amide bond and two alcohols Has no carboxylic acid, only alcohol.

To protect the skin means to prevent moisture evaporation of the skin and to prevent secondary infection of the skin, and various products are used as skin protection ingredients, but in the present invention, ceramide is used in consideration of stability, and moisturizing by hyaluronic acid In addition to the effect of maintaining and protecting moisture as well as strengthening the skin barrier function primarily to form a skin barrier to prevent allergic support or penetration of foreign substances, 0.01 ~ 1.0 for the whole composition It is preferable to use weight%.

If the amount of ceramide used is less than 0.01% by weight, the effect of addition is weak, and if it exceeds 1.0% by weight, the synergistic effect of addition is weak and it is not economical.

In the present invention, the coenzyme ubiquinone (coenzyme Q 10) is a physiological essential element widely distributed in biological organisms from bacteria to mammals, and is a component of the mitochondrial electron transport system in cells of biological organisms. It is a natural substance that is involved in repetitive oxidation and reduction reactions in, has strong antioxidant and whitening action and acts as a carrier component in electron transfer.

The content of the ubiquinone is preferably 0.1 to 3.0% by weight based on the total composition, when the content of the ubiquinone is less than 0.1% by weight, there is a problem that the effect of adding ubiquinone is weak. It may occur.

On the other hand, the DNA gel used in the present invention has a skin moisturizing and tissue repair function, the amount of the use is preferably 0.1 to 3.0% by weight based on the total composition, when the amount is less than 0.1% by weight, the addition effect is weak, 2.0 When it exceeds weight%, the synergistic effect of addition is weak and it is not economical.

In addition, the cocoa butter used in the present invention exhibits an excellent effect on the abdominal massage of pregnant women and plays a role of skin softening and moisture supply, it is preferable to use 1.0 to 5.0% by weight of the total composition, 0.1% by weight If less than, the effect of addition is insignificant, and if it exceeds 5.0% by weight, the addition synergistic effect is insignificant, which may not be economical, and may cause problems in the stability of the formulation.

The composition of the present invention is in addition to epidermal growth factor, fibroblast growth factor, vegetable amino acid peptide, polyglutamic acid, ceramide, ubiquinone, DNA gel and cocoa butter, in addition to fatty substances, organic solvents, solubilizers, thickening agents and gelling agents. , Emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, metal ion sequestrants and chelating agents, preservatives, vitamins, blockers, wetting It may contain adjuvants commonly used in the field of cosmetics or dermatology such as topical agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or any other ingredients conventionally used in cosmetics. In addition, the above components may be introduced in an amount generally used in the dermatology field.

In addition, formulations that can be applied when the ingredients according to the present invention are blended into the composition include lotion, cream, ointment, latex, foundation, oil, pack, soap (including medicated soap), body soap, lip balm, nail cosmetics , Eye cosmetics, perfume, face wash, mouthwash (toothpaste, mouse wash, etc.), deodorant (liquid, foot odor, etc.), bath solvent, shampoo, rinse, hair tonic, hair spray, hair dye, etc. And it mix | blends by a conventional component and method arbitrarily.

In addition, the form of the various compositions which mix | blended the component which concerns on this invention can be used as a solution form, a cream form, a paste form, a gel form, a gel form, foam form, solid form, or powder form.

The following Examples and Experimental Examples illustrate the present invention in more detail, but do not limit the scope of the invention.

Example  One

To prepare a cream according to the composition of the following Table 1.

Compounding ingredients Example 1 (% by weight) Epidermal growth factor 5 ppm Fibroblast growth factor 5 ppm Vegetable Amino Acid Peptides 3.0 Ceramide 0.5 Ubiquinone 1.5 DNA gel 1.0 Polyglutamic acid 1.5 Cocoa butter 3.0 Propylene glycol 9.0 glycerin 6.0 Triethanolamine 3.5 Beeswax 5.0 Tocopheryl Acetate 3.0 Polysorbate 60 5.0 Sorbitan sesquioleate 5.0 Cetearyl Alcohol 4.0 Liquid paraffin 47.5 Carboxy Vinyl Polymer 1.5 incense a very small amount

Experimental Example  One

The cream of Example 1 was used for 4 weeks of severity or higher inpatients with atopic dermatitis to improve dry skin, improve erythema, itch, duration of moisturizing, side effects, patient satisfaction, etc. A survey was conducted, the improvement effect was evaluated, and the results are shown in FIGS. 1 to 6.

Clinical subjects were divided into males and females under 5 years old, 5-15 years old and 15 years old or older, and males were 3 persons under 5 years old, 18 under 5-15 years old, and 14 people over 15 years old. The subjects were 25 females, 3 females under 5 years old, 8 females under 5-15 years old and 14 females over 15 years old.

The symptoms of atopic patients were sore and very severe (10%), severe (28%) patients, moderate (38%), mild (15%) patients and occasional (7%) patients.

As can be seen from Figures 1 to 6, the satisfaction of the improvement of dry skin was 75%, the improvement of erythema symptoms was about 55%, the itch improvement was about 52%, the duration of the moisturizing effect was The moisturizing duration was over 2 to 6 hours at 90% or more, and it was found that the moisturizing effect was equal to or higher than that of the conventional moisturizer, and more than 90% confirmed that the side effects were negligible and safe.

1 is a view showing a survey result for improving dry skin according to the composition of the present invention,

2 is a view showing the results of the survey for the improvement of erythema symptoms according to the composition of the present invention,

3 is a view showing the results of the survey for improving the itch according to the composition of the present invention,

4 is a view showing the results of the questionnaire survey for the moisturizing duration according to the composition of the present invention,

5 is a view showing the results of the survey for the moisturizing effect according to the composition of the present invention,

Figure 6 is a view showing the results of the survey on the degree of side effects according to the composition of the present invention.

Claims (1)

Epidermal growth factor and fibroblast growth factor were added in an amount of 0.01-20 ppm with respect to the total composition, 1.0-5.0 wt% of vegetable amino acid peptide, and 0.1-polyglutamic acid. 3.0 wt%, ceramide 0.01-1.0 wt%, ubiquinone (coenzyme Q10) 0.1-3.0 wt%, DNA-gel (gel) 0.1-3.0 wt% and cocoa butter 1.0-5.0 wt% Atopic composition for treatment.

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