KR20090090083A - Biomarker for identification of exposure to naphthalene and the method of identification using thereof - Google Patents
Biomarker for identification of exposure to naphthalene and the method of identification using thereof Download PDFInfo
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Abstract
Description
본 발명은 나프탈렌(naphthalene)에 대한 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법에 관한 것으로, 더욱 상세하게는 나프탈렌에 의해 유전자 발현이 증가 또는 감소하는 바이오마커 및 이를 이용한 나프탈렌에 대한 노출 여부를 확인하는 방법에 관한 것이다. The present invention relates to a biomarker for confirming the exposure to naphthalene (naphthalene) and a method of identifying the same, and more particularly to confirm that the biomarker is increased or decreased by naphthalene and the exposure to naphthalene using the same It is about how to.
나프탈렌(Naphthalene)은 2개의 인접한 벤젠 고리로 구성된 다환 방향족 탄화수소류로서 물에는 거의 녹지 않으며, 휘발성이 강해서 대기압에서 기체 상태로 존재한다. 주로 프탈레이트 가소제, 수지 및 의약품 생산의 중간체로서 존재하며, 독특한 향을 가지고 있어 곤충기피제나 방취제로 사용된다. 또한, 가솔린과 디젤연료 중에 존재하며 자동차를 포함한 광범위한 발생원으로 인해 나프탈렌 농도는 공간에 따라 변동이 크고 일일 및 계절에 따른 변동 폭도 큰 것으로 알려져 있다. 나프탈렌의 환경 중 이동은 휘발성이 강해서 토양이나 지표수 중에서 대기로 쉽게 배출되어지며 대기 중 반감기는 1일 미만으로 보고되고 있다. 또한, 나프탈렌의 광산화물인 나프토퀴논(naphthoquinone) 및 니트로-나프탈렌(nitro-naphthalene)은 나프탈렌 자체보다 독성이 강한 것으로 알려져 있다. Naphthalene is a polycyclic aromatic hydrocarbon composed of two adjacent benzene rings, almost insoluble in water and highly volatile and present in a gaseous state at atmospheric pressure. It is mainly used as an intermediate for the production of phthalate plasticizers, resins and pharmaceuticals. It has a unique fragrance and is used as an insect repellent or deodorant. In addition, it is known to exist in gasoline and diesel fuel, and due to a wide range of sources including automobiles, the naphthalene concentration is known to fluctuate with space and fluctuate with daily and season. The transport of naphthalene in the environment is highly volatile and easily released into the atmosphere from soil or surface water, and the half-life of the atmosphere is reported to be less than one day. In addition, naphthoquinone and nitro-naphthalene, which are photooxides of naphthalene, are known to be more toxic than naphthalene itself.
국내의 상수원수에서 검출되는 미량유해물질조사에서 나프탈렌이 0 ~ 4.6 ㎍/ℓ의 농도범위로 검출되었으며(환경부 자료실, 1996), 도시산업지역의 지하수 오염특성조사연구에서도 약 0.2 ㎍/ℓ의 농도로 검출되었다(이평구 등, 도시산업지역 지하수 오염특성 및 예방 기법연구, 2003). 작업장 중에서도 아스팔트 흄에서의 다환방향족탄화수소류의 성분별 분석연구에서는 4.7 mg/m2의 농도로 나타났다(최재욱 등, 건설업 근로자의 유해 작업 환경 노출 실태에 관한 연구, 2000). 국외의 경우, 미국의 자동차 배기가스로 인한 나프탈렌의 대기농도 조사에서 샌프란시스코의 칼데콧(Caldecott) 터널과 로스엔젤로스 밴 나이스(Van Nuys) 터널에서 수집한 시료에서 각각 104.3 와 1,709 ㎍/m2의 농도로 검출되었다(Zielinska & Fung, Sci Total Environ 146/147:281-8, 1994; Fraser et al., Environ Sci Technol 32:2051-2060, 1998).Naphthalene was detected in the concentration range of 0 ~ 4.6 ㎍ / ℓ in trace pollutants detected in domestic source water (Ministry of Environment, 1996), and the concentration of about 0.2 ㎍ / ℓ in groundwater pollution investigation in urban industrial areas. (Research on Groundwater Contamination and Prevention Techniques in Urban Industrial Areas, Epyeong-gu et al., 2003). Among the workplaces, an analysis of the composition of polycyclic aromatic hydrocarbons in asphalt fume showed a concentration of 4.7 mg / m 2 (Cho Jae Wook et al., 2000). Outside of the United States, concentrations of 104.3 and 1,709 μg / m 2 in samples collected from the Caldecott and Los Angeles van Nuys tunnels in San Francisco during the investigation of atmospheric concentrations of naphthalene from automobile emissions in the United States. (Zielinska & Fung, Sci Total Environ 146/147: 281-8, 1994; Fraser et al., Environ Sci Technol 32: 2051-2060, 1998).
동물실험 결과, 나프탈렌의 반복, 및 단기 노출은 일차적으로 간독성 및 신경독성을 유발하는 것으로 보고되어지고 있으나, DNA 손상, 유전자 돌연변이, 염색체구조이상 및 염색체 수적 이상, 차세대 유전 독성 가능성을 유발하지 않는 것으로 보아 인체에서 유전 독성을 보일 가능성은 희박한 것으로 사료된다(국립독성과 학원, 독성물질국가관리사업, 2007).In animal studies, repeated and short-term exposures to naphthalene have been reported to primarily induce hepatotoxicity and neurotoxicity, but do not induce DNA damage, gene mutations, chromosomal abnormalities and chromosomal abnormalities, and the possibility of next-generation genetic toxicity. It is considered that the human body is unlikely to show genetic toxicity (National Toxicology Institute, Toxic Substances Management Program, 2007).
또한, 나프탈렌은 세계보건기구(WHO) 산하의 국제암연구기관(IARC)에서 '인체 발암 가능성 물질'인 2B등급으로 분류하고 있으며(IARC, IARC Monogr Eval Carcinog Risks Hum 82: 367-435, 2002), 미국 환경부의 발암성 분류 등급에서는 ‘잠재적인 인체 발암물질’로 발암성 C등급으로 구분하고 있다(IRIS, U.S. Environmental Protection Agency Washington, DC: Integrated Risk Information System. http://www.epa.gov/iris/. June 6, 2003).In addition, naphthalene is classified by the International Cancer Research Organization (IARC) under the World Health Organization (IARC) as a 2B class, a human carcinogen (IARC, IARC Monogr Eval Carcinog Risks Hum 82: 367-435, 2002). The U.S. Department of Environment's carcinogenicity classification class is classified as a potential carcinogen C class (IRIS, US Environmental Protection Agency Washington, DC: Integrated Risk Information System. Http://www.epa.gov / iris /. June 6, 2003).
다환방향족 탄화수소류의 발암성 정도와 유전자 발현 변화에 대한 연구는 일부 보고되고 있지만, 대표적인 다환방향족 탄화수로류로 알려진 벤조에이파이렌(Benzo[a]pyrene)에 대한 연구에 거의 국한되어 있다. 이처럼 나프탈렌의 인간에 대한 발암 가능성에도 불구하고 인체에서의 위해도 평가 데이터가 충분하지 않고, 노출에 대한 검색 방법 역시 GC-MS(Gas Chromatography-Mass Spectrometer) 또는 HPLC(High Performance Liquid Chromatography) 등의 고전적인 방법에 국한되어 있다. GC-MS 또는 HPLC 방법 등을 이용하면 정량은 가능하나 분석을 위한 적정 조건을 설정하여야 하며 고가의 장비 등이 필요하다. 그러므로 보다 빠르고 간편한 스크리닝(screening) 방법, 예를 들면 프라이머(primer)를 이용하는 실시간(real-time) PCR(Real-time reverse transcript polymerase chain reaction) 또는 DNA 마이크로어레이 칩 등으로 신속한 위해성 평가를 통해 인체에서의 독성작용을 탐색할 수 있는 분자적 지표를 발굴하고 활용하여 나프탈렌의 노출에 대한 적절한 대책 및 관리를 수행하는 것이 중요한 과제라 하겠다.Although some studies on the degree of carcinogenicity and gene expression of polyaromatic hydrocarbons have been reported, they are almost limited to studies on Benzo [a] pyrene, which is known as a representative polycyclic aromatic hydrocarbon. Despite the potential for carcinogenicity to humans, naphthalene does not have sufficient risk assessment data in humans, and the method of exposure detection also includes classic methods such as Gas Chromatography-Mass Spectrometer (GC-MS) or High Performance Liquid Chromatography (HPLC). It is limited to the traditional way. Quantification is possible using GC-MS or HPLC methods, but appropriate conditions for analysis are required and expensive equipment is required. Therefore, faster and easier screening methods, such as real-time reverse transcript polymerase chain reaction (PCR) or DNA microarray chips using primers, can be used in humans through rapid risk assessment. It is an important task to identify and utilize the molecular indicators that can explore the toxic effects of chlorine, and to take appropriate measures and control against naphthalene exposure.
포유류 6종, 미생물 292종 등 여러 종의 게놈(genome) 염기서열 프로젝트가 완성되어 NCBI(National Center for Biotechnology Information)에 보고되었다. 이렇게 얻어진 막대한 양의 데이터를 기본으로 유전자의 기능을 연구하기 위하여 게놈-와이드 익스프레션(genome-wide expression) 연구가 이루어지고 있다. 한번의 실험으로 수천 개의 유전자의 발현을 분석하기 위하여 DNA 마이크로어레이(microarray) 분석을 수행한다(Schena, M., et al., Proc . Natl . Acad . Sci . USA 93:10614-10619, 1996). Several genome sequencing projects, including six mammals and 292 microbes, have been completed and reported to the National Center for Biotechnology Information (NCBI). Genome-wide expression studies are being conducted to study the function of genes based on the vast amount of data obtained. DNA microarray analysis is performed to analyze the expression of thousands of genes in one experiment (Schena, M., et al. , Proc . Natl . Acad . Sci . USA) . 93: 10614-10619, 1996).
마이크로어레이는 cDNA(complementary DNA)나 20 ~ 25 염기쌍(base pair) 길이의 올리고뉴클레오티드(oligonucleotide)들의 세트를 유리에 집적화한 것이다. cDNA 마이크로어레이는 학교 내의 연구실 또는 애질런트(Agilent), 지노믹 솔루션(Genomic Solutions) 등의 회사에서 칩 위에 cDNA 수집물을 기계적으로 고정화 하거나 잉크젯(ink jetting) 방법을 이용하여 생산하고 있다(Sellheyer K. et. al., J. Am . Acad . Dermatol. 51:681-692, 2004). 올리고뉴클레오티드 마이크로어레이는 애피매트릭스(Affymetrix)사에서 사진 식각 공정(photolithography)을 이용하여 칩 위에서 직접 합성하는 방법에 의해 만들어지고 있으며, 애질런트(Agillent)사 등에는 합성된 올리고뉴클레오티드를 고정화하는 방법으로 생산하고 있다(Sellheyer, K. et. al., J. Am . Acad . Dermatol. 51:681-692, 2004).Microarrays integrate cDNA (complementary DNA) or sets of oligonucleotides 20 to 25 base pairs in length on glass. cDNA microarrays are produced by labs in schools or by companies such as Agilent and Genomic Solutions, either mechanically immobilizing cDNA collections on chips or using ink jetting (Sellheyer K.). et. al., J. Am . Acad . Dermatol . 51: 681-692, 2004). Oligonucleotide microarrays are made by Affymetrix's method of direct synthesis on a chip using photolithography. (Sellheyer, K. et. Al., J. Am . Acad . Dermatol . 51: 681-692, 2004).
유전자의 발현 분석을 위해서는 조직 등 시료에서 RNA를 얻어 DNA 마이크로어레이에 있는 올리고뉴클레오티드와 교잡반응을 수행한다. 얻어진 RNA는 형광이나 동위원소로 표지화하며 cDNA로 전환시킨다. 올리고 마이크로어레이는 주로 두개의 다른 형광(예: Cye3 및 Cye5)으로 대조군과 실험군을 각각 표지화하여 같은 칩 상에서 동시에 교잡 반응을 수행한 후 광학적으로 이미지를 스캔하여 형광의 세기를 얻고 그 결과를 분석한다. 두 개의 형광 세기의 비율에 따라 유전자의 발현 여부를 결정한다(Somasundaram, K. et al., Genomics Proteomics I:1-10, 2002).For gene expression analysis, RNA is obtained from samples such as tissues and hybridized with oligonucleotides in a DNA microarray. The resulting RNA is labeled with fluorescence or isotope and converted to cDNA. Oligo microarrays are mainly labeled with two different fluorescences (eg, Cye3 and Cye5) to perform hybridization reactions on the same chip at the same time. . Gene expression is determined by the ratio of the two fluorescence intensities (Somasundaram, K. et al. , Genomics Proteomics I: 1-10, 2002).
최근 DNA 마이크로어레이 기술을 이용한 첨단 기법인 독성 유전체학(Toxicogenomics) 연구 등과 접목하여 대량(high throughput)으로 의약품 및 신의약 후보물질은 물론 대표적인 환경오염물질을 비롯하여 모든 화학물질에 의한 특정 조직이나 세포주에서 발현되는 유전자들의 발현 패턴의 분석, 양적 분석이 가능해졌다. 이에 따라 특정 세포 내에서 특정 유전자의 발현 빈도를 분석함으로써 약물의 부작용 및 환경오염물질의 유해작용과 관련된 유전자의 발굴이 가능하며, 이를 통하여 환경오염물질의 유해작용과 약물의 작용 및 부작용에 따른 분자적 메커니즘을 이해하게 될 것이며 나아가 독성 및 부작용을 유발하는 물질의 검색 및 이 가능하게 될 것이다. In combination with recent research on toxic genomics (Toxicogenomics), an advanced technique using DNA microarray technology, high-throughput expression in specific tissues or cell lines by all chemicals including pharmaceuticals and new drug candidates, as well as representative environmental pollutants Analysis and quantitative analysis of the expression patterns of genes are now possible. Accordingly, by analyzing the frequency of expression of specific genes in specific cells, it is possible to discover genes related to adverse effects of drugs and harmful effects of environmental pollutants. It will be possible to understand the specific mechanisms and further to search for substances that cause toxicity and side effects.
이에 본 발명자들은 인간 유전자 4만 4천 개가 집적된 올리고마이크로어레이를 이용하여 나프탈렌의 유전자 발현 프로파일을 인간 간암 세포인 HepG2 세포주에서 관찰 및 분석함으로써 나프탈렌에 의해 과발현 또는 저발현 되는 유전자를 발굴 하고, 실시간(real-time) RT-PCR 방법에 의해 상기 유전자들의 발현 양상을 확인함으로써 나프탈렌을 검출할 수 있는 바이오마커 및 이를 이용한 노출 여부를 확인하는 방법을 확립하여 본 발명을 완성하였다.Therefore, the inventors have discovered and analyzed the gene expression profile of naphthalene in HepG2 cell line, which is human liver cancer cells, using oligomicroarray accumulated with 44,000 human genes, to discover genes overexpressed or underexpressed by naphthalene, and in real time. The present invention was completed by establishing a biomarker capable of detecting naphthalene and a method of detecting exposure using the same by confirming the expression pattern of the genes by real-time RT-PCR method.
본 발명의 목적은 나프탈렌(Naphthalene)의 노출에 의해 과발현 또는 저발현되는 바이오마커 및 상기 바이오마커를 이용한 나프탈렌에 대한 노출 여부를 확인하는 방법을 제공하는 것이다.It is an object of the present invention to provide a biomarker that is overexpressed or underexpressed by exposure of naphthalene and a method for identifying exposure to naphthalene using the biomarker.
상기 목적을 달성하기 위하여, 본 발명은 나프탈렌(naphthalene)의 노출에 의해 발현 변화를 일으키는 것을 특징으로 하는 나프탈렌에 대한 노출 여부 확인용 바이오마커를 제공한다.In order to achieve the above object, the present invention provides a biomarker for confirming the exposure to naphthalene, characterized in that the expression changes by the exposure of naphthalene (naphthalene).
또한, 본 발명은 상기 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 이의 상보가닥 분자가 집적된 나프탈렌에 대한 노출 여부 확인용 DNA 마이크로어레이 칩을 제공한다.In another aspect, the present invention provides a DNA microarray chip for confirming the exposure to naphthalene in which the oligonucleotide or its complementary strand molecules including all or part of the biomarker gene sequence are integrated.
또한, 본 발명은 상기 바이오마커를 이용한 나프탈렌에 대한 노출 여부를 확인하는 방법을 제공한다.In addition, the present invention provides a method for confirming the exposure to naphthalene using the biomarker.
아울러, 본 발명은 나프탈렌에 대한 노출 여부 확인용 검색 키트를 제공한다.In addition, the present invention provides a search kit for confirming the exposure to naphthalene.
본 발명의 나프탈렌(naphthalene)에 대한 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법은 DNA 마이크로어레이 칩을 통하여 선별된 반응 유전자들을 바이오마커로 이용하여 나프탈렌의 모니터링 및 위해성을 판정하는데 유용하며, 나프탈렌에 의해 야기되는 독성 작용 기작을 규명하는 도구로 이용할 수 있다.The biomarker for confirming the exposure to naphthalene and the identification method using the same of the present invention are useful for determining the risk and monitoring of naphthalene using the reaction genes selected through DNA microarray chips as biomarkers. It can be used as a tool to identify the mechanism of toxic effects caused by.
이하, 본 발명을 상세히 설명한다.Hereinafter, the present invention will be described in detail.
본 발명은 나프탈렌(naphthalene)의 노출에 의해 발현 변화를 일으키는 것을 특징으로 하는 나프탈렌에 대한 노출 여부 확인용 바이오마커를 제공한다.The present invention provides a biomarker for confirming exposure to naphthalene, characterized by causing a change in expression by exposure of naphthalene.
상기 바이오마커는 2배 이상 발현이 증가 또는 감소한 유전자로써, 세포 주기(cell cycle), 세포 성장(cell growth), 세포 이동(cell migration), 아팝토시스(apoptosis), 전사(transcription), 뉴클레오티드 결합(nucleotide binding), 금속원소 결합(metal binding), 자극에 대한 반응(Response to stimulus), 징크-핑거(Zinc-finger), 단백질 전달(protein transport), 면역반응(immune response), MAPKinase 신호 경로(MAPKinase signaling Pathway), WNT 신호 경로(WNT signaling pathway), 지방산 대사(fatty acid metabolism), 지질 대사(lipid metabolism), 사이토크롬에 의한 외부물질의 대사(metabolism of xenobiotics by cytochrome), 알코올 대사(Alcohol metabolism), DNA 손상 반응(response to DNA damage stimulus) 또는 갭 결합(Gap Junction) 등의 관련 유전자로 구성되어 있다.The biomarker is a gene whose expression is increased or decreased more than two times, and includes cell cycle, cell growth, cell migration, apoptosis, transcription, and nucleotide binding. (nucleotide binding), metal binding, response to stimulus, zinc-finger, protein transport, immune response, MAPKinase signaling pathways ( MAPKinase signaling Pathway, WNT signaling pathway, fatty acid metabolism, lipid metabolism, metabolism of xenobiotics by cytochrome, alcohol metabolism ), Related genes such as response to DNA damage stimulus or gap junction.
본 발명은 하기와 같이 구성된 군에서 선택되어지는 것을 특징으로 하는 바 이오마커를 제공한다: The present invention provides a biomarker characterized in that it is selected from the group consisting of:
유전자 등록번호(Genebank) BC063507(HSPA1B, Heat shock 70kDa protein 1B), 유전자 등록번호(Genebank) NM_016639(TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), 유전자 등록번호(Genebank) NM_033027(AXUD1, AXIN1 up-regulated 1), 유전자 등록번호(Genebank) AF332558(BBC3, BCL2 binding component 3), 유전자 등록번호(Genebank) NM_138639(BCL2L12, BCL2-like 12(proline rich)), 유전자 등록번호(Genebank) AK124526(BCAR1, Breast cancer anti-estrogen resistance 1), 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) AB209095(CDC2L2, Cell division cycle 2-like 2(PITSLRE proteins)), 유전자 등록번호(Genebank) AK128462(CRR9, Cisplatin resistance related protein CRR9p), 유전자 등록번호(Genebank) NM_016222(DDX41, DEAD(Asp-Glu-Ala-Asp) box polypeptide 41), 유전자 등록번호(Genebank) NM_022105(DATF1, Death inducer-obliterator 1), 유전자 등록번호(Genebank) AK127033(DNM2, Dynamin 2), 유전자 등록번호(Genebank) NM_152461(ERN1, Endoplasmic reticulum to nucleus signalling 1), 유전자 등록번호(Genebank) NM_003806(HRK, Harakiri, BCL2 interacting protein(contains only BH3 domain)), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) NM_003639(IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), 유전자 등록번호(Genebank) BX640923(MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein(mouse)), 유전자 등록번호(Genebank) NM_002648(PIM1, Pim-1 oncogene), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_004309(ARHGDIA, Rho GDP dissociation inhibitor(GDI) alpha), 유전자 등록번호(Genebank) BC041022(SCAND1, SCAN domain containing 1), 유전자 등록번호(Genebank) NM_006282(STK4, Serine/threonine kinase 4), 유전자 등록번호(Genebank) AB005666(SIPA1, Signal-induced proliferation-associated gene 1), 유전자 등록번호(Genebank) NM_207111(TRIAD3, TRIAD3 protein), 유전자 등록번호(Genebank) AY247738(TRIB3, Tribbles homolog 3(Drosophila)), 유전자 등록번호(Genebank) AF026071(TNFRSF25, Tumor necrosis factor receptor superfamily, member 25), 유전자 등록번호(Genebank) AB209485(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) CR606241(ACTG1, Actin, gamma 1), 유전자 등록번호(Genebank) NM_012127(CIZ1, CDKN1A interacting zinc finger protein 1), 유전자 등록번호(Genebank) AK057576(CHFR, Checkpoint with forkhead and ring finger domains), 유전자 등록번호(Genebank) NM_005255(GAK, Cyclin G associated kinase), 유전자 등록번호(Genebank) NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) AK094316(MAD2L2, MAD2 mitotic arrest deficient-like 2(yeast)), 유전자 등록번호(Genebank) NM_002595(PCTK2, PCTAIRE protein kinase 2), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform b, alpha subunit 45kDa), 유전자 등록번호(Genebank) X06374(PDGFA, Platelet-derived growth factor alpha polypeptide), 유전자 등록번호(Genebank) NM_001722(POLR3D, Polymerase(RNA) III(DNA directed) polypeptide D, 44kDa), 유전자 등록번호(Genebank) NM_002808(PSMD2, Proteasome(prosome, macropain) 26S subunit, non-ATPase, 2), 유전자 등록번호(Genebank) BC038504(SNF1LK, SNF1-like kinase), 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) NM_000548(TSC2, Tuberous sclerosis 2), 유전자 등록번호(Genebank) AK223618(ZBTB17, Zinc finger and BTB domain containing 17), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) AY258066(OKL38, Pregnancy-induced growth inhibitor), 유전자 등록번호(Genebank) NM_001012661(SLC3A2, Solute carrier family 3(activators of dibasic and neutral amino acid transport), member 2), 유전자 등록번호(Genebank) NM_014598(SOCS7, Suppressor of cytokine signaling 7), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) NM_015366(FLJ20185, Rho GTPase activating protein 8), 유전자 등록번호(Genebank) AB209322(SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted,(semaphorin) 3B), 유전자 등록번호(Genebank) AB209463(CSNK1D, Casein kinase 1, delta), 유전자 등록번호(Genebank) NM_005228(EGFR, Epidermal growth factor receptor(erythroblastic leukemia viral(v-erb-b) oncogene homolog, avian)), 유전자 등록번호(Genebank) BC089041(GNA11, Guanine nucleotide binding protein(G protein), alpha 11(Gq class)), 유전자 등록번호(Genebank) NM_002224(ITPR3, Inositol 1,4,5-triphosphate receptor, type 3), 유전자 등록번호(Genebank) NM_012463(ATP6V0A2, ATPase, H+transport -ing, lysosomal V0 subunit a isoform 2), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) NM_000574(DAF, Decay accelerating factor for complement(CD55, Cromer blood group system)), 유전자 등록번호(Genebank) NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), 유전자 등록번호(Genebank) BG171626(FTH1, Ferritin, heavy polypeptide 1), 유전자 등록번호(Genebank) BM905227(FTH1, Ferritin, heavy polypeptide 1), 유전자 등록번호(Genebank) NM_001015053(HDAC5, Histone deacetylase 5), 유전자 등록번호(Genebank) NM_003641(IFITM1, Interferon induced transmembrane protein 1(9-27)), 유전자 등록번호(Genebank) AF200496(IL1F7, Interleukin 1 family, member 7(zeta)), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) NM_000565(IL6R, Interleukin 6 receptor), 유전자 등록번호(Genebank) NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)), 유전자 등록번호(Genebank) NM_001300(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), 유전자 등록번호(Genebank) NM_017670(OTUB1, OTU domain, ubiquitin aldehyde binding 1), 유전자 등록번호(Genebank) NM_139276(STAT3, Signal transducer and activator of transcription 3(acute-phase response factor)), 유전자 등록번호(Genebank) NM_003037(SLAMF1, Signaling lymphocytic activation molecule family member 1), 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) NM_001353(AKR1C1, Aldo-keto reductase family 1, member C1(dihydrodiol dehydrogenase 1; 20-alpha(3-alpha)-hydroxysteroid dehydrogenase)), 유전자 등록번호(Genebank) NM_001769(CD9, CD9 antigen(p24)), 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK095781(CIRBP, Cold inducible RNA binding protein), 유전자 등록번호(Genebank) X14789(CRYAA, Crystallin, alpha A), 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_080927(DCBLD2, Discoidin, CUB and LCCL domain containing 2), 유전자 등록번호(Genebank) AY253982(GPR54, G protein-coupled receptor 54), 유전자 등록번호(Genebank) AF073799(GALR3, Galanin receptor 3), 유전자 등록번호(Genebank) BI767815(GP9, Glycoprotein IX(platelet)), 유전자 등록번호(Genebank) NM_007353(GNA12, Guanine nucleotide binding protein(G protein) alpha 12), 유전자 등록번호(Genebank) CR623806(HSPA6, Heat shock 70kDa protein 6(HSP70B')), 유전자 등 록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK000252(FLJ20245, Hypothetical protein FLJ20245), 유전자 등록번호(Genebank) AK057577(IRF3, Interferon regulatory factor 3), 유전자 등록번호(Genebank) L76191(IRAK1, Interleukin-1 receptor-associated kinase 1), 유전자 등록번호(Genebank) BC053882(MT1X, Metallothionein 1X), 유전자 등록번호(Genebank) AK124709(NDRG1, N-myc downstream regulated gene 1), 유전자 등록번호(Genebank) NM_002658(PLAU, Plasminogen activator, urokinase), 유전자 등록번호(Genebank) U02389(PRSS15, Protease, serine, 15), 유전자 등록번호(Genebank) NM_005053(RAD23A, RAD23 homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) CD357517(Unknown, Similar to Interferon-induced transmembrane protein 3(Interferon-inducible protein 1-8U)), 유전자 등록번호(Genebank) NM_032038(SPINL, Spinster), 유전자 등록번호(Genebank) H18681(C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BX648190(WDR1, WD repeat domain 1), 유전자 등록번호(Genebank) AK074035(XAB2, XPA binding protein 2), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_017572(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_030662(MAP2K2, Mitogen-activated protein kinase kinase 2), 유전자 등록번호(Genebank) AB208849(SHC1, SHC(Src homology 2 domain containing) transforming protein 1), 유전자 등록번호(Genebank) NM_138473(SP1, Sp1 transcription factor), 유전자 등록번호(Genebank) X02812(TGFB1, Transforming growth factor, beta 1(Camurati-Engelmann disease)), 유전자 등록번호(Genebank) NM_002880(RAF1, V-raf-1 murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_152221(CSNK1E, Casein kinase 1, epsilon), 유전자 등록번호(Genebank) AB209210(DVL1, Dishevelled, dsh homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) AF077820(LRP5, Low density lipoprotein receptor-related protein 5), 유전자 등록번호(Genebank) NM_033119(NKD1, Naked cuticle homolog 1(Drosophila)), 유전자 등록번호(Genebank) AK090488(PPP2R1A, Protein phosphatase 2(formerly 2A), regulatory subunit A(PR 65), alpha isoform), 유전자 등록번호(Genebank) AL834166(TCF7, Transcription factor 7(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) AY009401(WNT6, Wingless-type MMTV integration site family, member 6), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003255(TIMP2, TIMP metallopeptidase inhibitor 2), 유전자 등록번호(Genebank) NM_014595(NT5C, 5', 3'-nucleotidase, cytosolic), 유전자 등록번호(Genebank) AY461712(ATP13A2, ATPase type 13A2), 유전자 등록번호(Genebank) NM_018590(GALNACT-2, Chondroitin sulfate GalNAcT-2), 유전자 등록번호(Genebank) NM_080757(C20orf127, Chromosome 20 open reading frame 127), 유전자 등록번호(Genebank) X16866(CYP2D7P1, Cytochrome P450, family 2, subfamily D, polypeptide 6), 유전자 등록번호(Genebank) NM_000782(CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), 유전자 등록번호(Genebank) NM_000786(CYP51A1, Cytochrome P450, family 51, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_017556(FBLP-1, Filamin binding LIM protein 1), 유전자 등록번호(Genebank) AK093560(INPP1, Inositol polyphosphate-1-phosphatase), 유전자 등록번호(Genebank) NM_005578(LPP, LIM domain containing preferred translocation partner in lipoma), 유전자 등록번호(Genebank) AK222601(MMP10, Matrix metallopeptidase 10(stromelysin 2)), 유전자 등록번호(Genebank) NM_005947(MT1B, Metallothionein 1B(functional)), 유전자 등록번호(Genebank) BC048334(MT1G, Metallothionein 1G), 유전자 등록번호(Genebank) BI488702(MT1K, Metallothionein 1M), 유전자 등록번호(Genebank) NM_182924(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK127759(NDUFS7, NADH dehydrogenase(ubiquinone) Fe-S protein 7, 20kDa(NADH-coenzyme Q reductase)), 유전자 등록번호(Genebank) NM_203353(PDLIM7, PDZ and LIM domain 7(enigma)), 유전자 등록번호(Genebank) NM_002627(PFKP, Phosphofructokinase, platelet), 유전자 등록번호(Genebank) AA862994(S100A3, S100 calcium binding protein A3), 유전자 등록번호(Genebank) NM_003461(ZYX, Zyxin), 유전자 등록번호(Genebank) NM_019112(ABCA7, ATP-binding cassette, sub-family A(ABC1), member 7), 유전자 등록번호(Genebank) AB209054(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), 유전자 등록번호(Genebank) NM_020038(ABCC3, ATP-binding cassette, sub-family C(CFTR/MRP), member 3), 유전자 등록번호(Genebank) BC025358(ABCD1, ATP-binding cassette, sub-family D(ALD), member 1), 유전자 등록번호(Genebank) NM_003992(CLK3, CDC-like kinase 3), 유전자 등록번호(Genebank) AK128154(C9orf86, Chromosome 9 open reading frame 86), 유전자 등록번호(Genebank) BC006404(SKD3, ClpB caseinolytic peptidase B homolog(E. coli)), 유전자 등록번호(Genebank) BC067254(COASY, Coenzyme A synthase), 유전자 등록번호(Genebank) NM_004398(DDX10, DEAD(Asp-Glu-Ala-Asp) box polypeptide 10), 유전자 등록번호(Genebank) BC038417(DHX30, DEAH(Asp-Glu-Ala-His) box polypeptide 30), 유전자 등록번호(Genebank) NM_138614(DHX30, DEAH(Asp-Glu-Ala-His) box polypeptide 30), 유전자 등록번호(Genebank) NM_032656(DHX37, DEAH(Asp-Glu-Ala-His) box polypeptide 37), 유전자 등록번호(Genebank) NM_020812(DOCK6, Dedicator of cytokinesis 6), 유전자 등록번호(Genebank) NM_004431(EPHA2, EPH receptor A2), 유전자 등록번호(Genebank) NM_001961(EEF2, Eukaryotic translation elongation factor 2), 유전자 등록번호(Genebank) NM_003751(EIF3S9, Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa), 유전자 등록번호(Genebank) AF114818(SIAHBP1, Fuse-binding protein-interacting repressor), 유전자 등록번호(Genebank) NM_019096(GTPBP2, GTP binding protein 2), 유전자 등록번호(Genebank) NM_006572(GNA13, Guanine nucleotide binding protein(G protein), alpha 13), 유전자 등록번호(Genebank) AK128226(HK1, Hexokinase 1), 유전자 등록번호(Genebank) BC069201(FLJ22761, Hexokinase domain containing 1), 유전자 등록번호(Genebank) NM_006546(IMP-1, IGF-II mRNA-binding protein 1), 유전자 등록번호(Genebank) NM_015155(KIAA0217, La ribonucleoprotein domain family, member 5), 유전자 등록번호(Genebank) NM_018357(FLJ11196, La ribonucleoprotein domain family, member 6), 유전자 등록번호(Genebank) AK127089(MTHFD1L, Methylenetetrahydrofolate dehydrogenase(NADP+ dependent) 1-like), 유전자 등록번호(Genebank) XM_038150(MAST3, Microtubule associated serine/threonine kinase 3), 유전자 등록번호(Genebank) AB058686(MYO15B, Myosin XVB pseudogene), 유전자 등록번호(Genebank) BC027875(MYO15B, Myosin XVB pseudogene), 유전자 등록번호(Genebank) K122664(NRBP, Nuclear receptor binding protein), 유전자 등록번호(Genebank) NM_001001852(PIM3, Pim-3 oncogene), 유전자 등록번호(Genebank) BC094766(PKN1, Protein kinase N1), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_019034(RHOF, Ras homolog gene family, member F(in filopodia)), 유전자 등록번호(Genebank) NM_016084(RASD1, RAS, dexamethasone-induced 1), 유전자 등록번호(Genebank) AY369207(RBPMS2, RNA binding protein with multiple splicing 2), 유전자 등록번호(Genebank) BC069233(SCYL1, SCY1-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) AB209553(STK11, Serine/threonine kinase 11), 유전자 등록번호(Genebank) AK124047(C20orf119, Similar to embryonic poly(A) binding protein), 유전자 등록번호(Genebank) XM_496374(LOC440595, Similar to eukaryotic translation elongation factor 1 alpha 1), 유전자 등록번호(Genebank) NM_005094(SLC27A4, Solute carrier family 27(fatty acid transporter), member 4) 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) NM_025195(TRIB1, Tribbles homolog 1(Drosophila)), 유전자 등록번호(Genebank) BC009900(UBE1, Ubiquitin-activating enzyme E1(A1S9T and BN75 temperature sensitivity complementing)), 유전자 등록번호(Genebank) AF045458(ULK1, Unc-51-like kinase 1(C. elegans)), 유전자 등록번호(Genebank) X59303(VARS2, Valyl-tRNA synthetase), 유전자 등록번호(Genebank) AB209808(AP1M1, Adaptor-related protein complex 1, mu 1 subunit), 유전자 등록번호(Genebank) AB208804(AP3D1, Adaptor-related protein complex 3, delta 1 subunit), 유전자 등록번호(Genebank) BC000786(ARFGAP1, ADP- ribosylation factor GTPase activating protein 1), 유전자 등록번호(Genebank) AK125277(APG4B, ATG4 autophagy related 4 homolog B(S. cerevisiae)), 유전자 등록번호(Genebank) NM_007097(CLTB, Clathrin, light polypeptide(Lcb)), 유전자 등록번호(Genebank) AK091056(COBRA1, Cofactor of BRCA1), 유전자 등록번호(Genebank) AF349676(COG3, Component of oligomeric golgi complex 3), 유전자 등록번호(Genebank) AB002368(XPO6, Exportin 6), 유전자 등록번호(Genebank) BX648781(GABARAPL1, GABA(A) receptor-associated protein like 1), 유전자 등록번호(Genebank) AK123405(GDI1, GDP dissociation inhibitor 1), 유전자 등록번호(Genebank) NM_004712(HGS, Hepatocyte growth factor-regulated tyrosine kinase substrate), 유전자 등록번호(Genebank) AK094897(IPO4, Importin 4), 유전자 등록번호(Genebank) L38951(KPNB1, Karyopherin(importin) beta 1), 유전자 등록번호(Genebank) NM_002268(KPNA4, Karyopherin alpha 4(importin alpha 3)), 유전자 등록번호(Genebank) AY014403(KIF13A, Kinesin family member 13A), 유전자 등록번호(Genebank) NM_002867(RAB3B, RAB3B, member RAS oncogene family), 유전자 등록번호(Genebank) AK025300(RANBP3, RAN binding protein 3), 유전자 등록번호(Genebank) AB014551(ARHGEF2, Rho/rac guanine nucleotide exchange factor(GEF) 2), 유전자 등록번호(Genebank) CD049342(RPL23, Ribosomal protein L23), 유전자 등록번호(Genebank) NM_005843(STAM2, Signal transducing adaptor molecule(SH3 domain and ITAM motif) 2), 유전자 등록번호(Genebank) NM_006809(TOMM34, Translocase of outer mitochondrial membrane 34), 유전자 등 록번호(Genebank) BC047528(TOMM40, Translocase of outer mitochondrial membrane 40 homolog(yeast)), 유전자 등록번호(Genebank) AK056701(VPS11, Vacuolar protein sorting 11(yeast)), 유전자 등록번호(Genebank) BC042390(VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)), 유전자 등록번호(Genebank) AK095154(AES, Amino-terminal enhancer of split), 유전자 등록번호(Genebank) BC060828(ARID3A, AT rich interactive domain 3A(BRIGHT- like)), 유전자 등록번호(Genebank) NM_003670(BHLHB2, Basic helix-loop-helix domain containing, class B, 2), 유전자 등록번호(Genebank) NM_006442(DRAP1, DR1-associated protein 1(negative cofactor 2 alpha)), 유전자 등록번호(Genebank) NM_006532(ELL, Elongation factor RNA polymerase II), 유전자 등록번호(Genebank) NM_001991(EZH1, Enhancer of zeste homolog 1(Drosophila)), 유전자 등록번호(Genebank) U18018(ETV4, Ets variant gene 4(E1A enhancer binding protein, E1AF)), 유전자 등록번호(Genebank) NM_002018(FLII, Flightless I homolog(Drosophila)), 유전자 등록번호(Genebank) NM_181430(FOXK2, Forkhead box K2), 유전자 등록번호(Genebank) NM_001012426(FOXP4, Forkhead box P4), 유전자 등록번호(Genebank) BC053850(FOXQ1, Forkhead box Q1), 유전자 등록번호(Genebank) AF176422(HEY1, Hairy/enhancer-of-split related with YRPW motif 1), 유전자 등록번호(Genebank) BC078664(HMGA1, High mobility group AT-hook 1), 유전자 등록번호(Genebank) XM_379934(KIAA1718, KIAA1718 protein), 유전자 등록번호(Genebank) BC069156(LBX1, Ladybird homeobox homolog 1(Drosophila)), 유전 자 등록번호(Genebank) NM_014520(MYBBP1A, MYB binding protein(P160) 1a), 유전자 등록번호(Genebank) NM_002518(NPAS2, Neuronal PAS domain protein 2), 유전자 등록번호(Genebank) NM_001001716(NFKBIB, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta), 유전자 등록번호(Genebank) AF087856(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002653(PITX1, Paired-like homeodomain transcription factor 1), 유전자 등록번호(Genebank) NM_001003891(PCQAP, PC2(positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein), 유전자 등록번호(Genebank) NM_005035(POLRMT, Polymerase(RNA) mitochondrial(DNA directed)), 유전자 등록번호(Genebank) NM_012448(STAT5B, Signal transducer and activator of transcription 5B), 유전자 등록번호(Genebank) CR607342(RNPS1, Similar to splicing-related factor RNPS1), 유전자 등록번호(Genebank) NM_005986(SOX1, SRY(sex determining region Y)-box 1), 유전자 등록번호(Genebank) NM_003072(SMARCA4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4), 유전자 등록번호(Genebank) NM_006951(TAF5, TAF5 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 100kDa), 유전자 등록번호(Genebank) NM_152380(TBX15, T-box 15), 유전자 등록번호(Genebank) NM_016569(TBX3, T-box 3(ulnar mammary syndrome)), 유전자 등록번호(Genebank) BC006396(TLX2, T-cell leukemia, homeobox 2), 유전자 등록번호(Genebank) AF106934(THRAP5, Thyroid hormone receptor associated protein 5), 유전자 등록번호(Genebank) AF108461(UBN1, Ubinuclein 1), 유전자 등록번호(Genebank) NM_002359(MAFG, V-maf musculoaponeurotic fibrosarcoma oncogene homolog G(avian)), 유전자 등록번호(Genebank) AK092414(MAFK, V-maf musculoaponeurotic fibrosarcoma oncogene homolog K(avian)), 유전자 등록번호(Genebank) AK128553(ZZANK1, Mindbomb homolog 2(Drosophila)), 유전자 등록번호(Genebank) NM_001003694(BRPF1, Bromodomain and PHD finger containing, 1), 유전자 등록번호(Genebank) CR936799(FHL2, Four and a half LIM domains 2), 유전자 등록번호(Genebank) NM_139201(GIT2, G protein-coupled receptor kinase interactor 2), 유전자 등록번호(Genebank) AK125974(p66alpha, GATA zinc finger domain containing 2A), 유전자 등록번호(Genebank) CB050471(GLI4, GLI-Kruppel family member GLI4), 유전자 등록번호(Genebank) NM_006734(HIVEP2, Human immunodeficiency virus type I enhancer binding protein 2), 유전자 등록번호(Genebank) NM_031297(DKFZP761H1710, Hypothetical protein DKFZp761H1710), 유전자 등록번호(Genebank) NM_024671(FLJ23436, Hypothetical protein FLJ23436), 유전자 등록번호(Genebank) NM_173680(MGC33584, Hypothetical protein MGC33584), 유전자 등록번호(Genebank) NM_031918(KLF16, Kruppel-like factor 16), 유전자 등록번호(Genebank) BU163740(MKRN1, Makorin, ring finger protein, 1), 유전자 등록번호(Genebank) NM_005885(MARCH-V, Membrane-associated ring finger(C3HC4) 6), 유전자 등록번호(Genebank) AF242768(LOC51333, Mesenchymal stem cell protein DSC43), 유전자 등록번호(Genebank) NM_020774(MIB1, Mindbomb homolog 1(Drosophila)), 유전자 등록번호(Genebank) AJ007041(MLL4, Myeloid/lymphoid or mixed-lineage leukemia 4), 유전자 등록번호(Genebank) BF206103(ZNF286, Peroxisome proliferative activated receptor, alpha-like), 유전자 등록번호(Genebank) BC008834(PHF1, PHD finger protein 1), 유전자 등록번호(Genebank) D87076(PHF15, PHD finger protein 15), 유전자 등록번호(Genebank) NM_020122(KCMF1, Potassium channel modulatory factor 1), 유전자 등록번호(Genebank) NM_145214(TRIM11, Tripartite motif-containing 11), 유전자 등록번호(Genebank) NM_033452(TRIM47, Tripartite motif-containing 47), 유전자 등록번호(Genebank) AF281046(TRIM8, Tripartite motif-containing 8), 유전자 등록번호(Genebank) BC004256(ZNF259, Zinc finger protein 259), 유전자 등록번호(Genebank) CR597101(ZFP36, Zinc finger protein 36, C3H type, homolog(mouse)), 유전자 등록번호(Genebank) NM_198055(ZNF42, Zinc finger protein 42(myeloid-specific retinoic acid-responsive)), 유전자 등록번호(Genebank) BC071620(ZNF581, Zinc finger protein 581), 유전자 등록번호(Genebank) BM544755(ZNF593, Zinc finger protein 593), 유전자 등록번호(Genebank) AK024487(ZNF598, Zinc finger protein 598), 유전자 등록번호(Genebank) BC089449(ZEC, Zinc finger protein 628), 유전자 등록번호(Genebank) NM_153813(ZFPM1, Zinc finger protein, multitype 1), 유전자 등록번호(Genebank) BM451410(ZA20D2, Zinc finger, A20 domain containing 2), 유전자 등록번호(Genebank) BX648551(ZA20D2, Zinc finger, A20 domain containing 2), 유전자 등록번호(Genebank) BC006340(ZCCHC2, Zinc finger, CCHC domain containing 2), 유전자 등록번호(Genebank) BC053544(ZDHHC8, Zinc finger, DHHC-type containing 8), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BQ939577(AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)), 유전자 등록번호(Genebank) AB045292(TMEM8, Transmembrane protein 8(five membrane-spanning domains)), 유전자 등록번호(Genebank) NM_012088(PGLS, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) NM_184041(ALDOA, Aldolase A, fructose-bisphosphate), 유전자 등록번호(Genebank) NM_000402(G6PD, Glucose-6-phosphate dehydrogenase), 유전자 등록번호(Genebank) NM_006715(MAN2C1, Mannosidase, alpha, class 2C, member 1), 유전자 등록번호(Genebank) CR597860(C19orf27, Chromosome 19 open reading frame 27), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) BC042195(MT, Malonyl-CoA:acyl carrier protein transacylase, mitochondrial), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) AK057049(PTGES2, Prostaglandin E synthase 2), 유전자 등록번호(Genebank) AB046825(GBA2, Glucosidase, beta(bile acid) 2), 유전자 등록번호(Genebank) BC033110(HSD17B1, Hydroxysteroid(17-beta) dehydrogenase 1), 유전자 등록번호(Genebank) BC050553(NTE, Neuropathy target esterase), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) NM_005028(PIP5K2A, Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha), 유전자 등록번호(Genebank) BC007612(PSAP, Prosaposin(variant Gaucher disease and variant metachromatic leukodystrophy)), 유전자 등록번호(Genebank) BC087612(SBF1, SET binding factor 1), 유전자 등록번호(Genebank) BQ683841(S100A11, S100 calcium binding protein A11(calgizzarin)), 유전자 등록번호(Genebank) CK000930(HIST1H2AI, Histone 1, H2ai), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) BC069193(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK223291(MMP3, Matrix metallopeptidase 3(stromelysin 1, progelatinase)), 유전자 등록번호(Genebank) NM_178819(DKFZp586M1819, 1-acylglycerol-3-phosphate O-acyltransferase 6(lysophosphatidic acid acyltransferase, zeta)), 유전자 등록번호(Genebank) NM_018694(ARL6IP4, ADP-ribosylation-like factor 6 interacting protein 4), 유전자 등록번호(Genebank) BC014895(MGC10204, Aldehyde dehydrogenase 16 family, member A1), 유전자 등록번호(Genebank) NM_032468(ASPH, Aspartate beta-hydroxylase), 유전자 등록번 호(Genebank) BC008751(CAPN1, Calpain 1,(mu/I) large subunit), 유전자 등록번호(Genebank) AK128552(CAPN10, Calpain 10), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) NM_001903(CTNNA1, Catenin(cadherin-associated protein), alpha 1, 102kDa), 유전자 등록번호(Genebank) BC067289(CTSL2, Cathepsin L2), 유전자 등록번호(Genebank) NM_015151(C21orf106, Chromosome 21 open reading frame 106), 유전자 등록번호(Genebank) NM_031434(C7orf21, Chromosome 7 open reading frame 21), 유전자 등록번호(Genebank) NM_001303(COX10, COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase(yeast)), 유전자 등록번호(Genebank) BP317375(COX6A2, Cytochrome c oxidase subunit VIa polypeptide 2), 유전자 등록번호(Genebank) NM_001355(DDT, D-dopachrome tautomerase), 유전자 등록번호(Genebank) NM_032482(DOT1L, DOT1-like, histone H3 methyltransferase(S. cerevisiae)), 유전자 등록번호(Genebank) NM_004419(DUSP5, Dual specificity phosphatase 5), 유전자 등록번호(Genebank) AB210013(EIF4G1, Eukaryotic translation initiation factor 4 gamma, 1), 유전자 등록번호(Genebank) NM_020158(EXOSC5, Exosome component 5), 유전자 등록번호(Genebank) NM_178225(FBXW5, F-box and WD-40 domain protein 5), 유전자 등록번호(Genebank) NM_058229(FBXO32, F-box protein 32), 유전자 등록번호(Genebank) AB209592(GMPPA, GDP-mannose pyrophosphorylase A), 유전자 등록번호(Genebank) AJ002231(GNPDA1, Glucosamine-6-phosphate deaminase 1), 유전자 등록번 호(Genebank) AK094940(GCLC, Glutamate-cysteine ligase, catalytic subunit), 유전자 등록번호(Genebank) NM_005318(H1F0, H1 histone family, member 0), 유전자 등록번호(Genebank) NM_004639(BAT3, HLA-B associated transcript 3), 유전자 등록번호(Genebank) NM_032717(MGC11324, Hypothetical protein MGC11324), 유전자 등록번호(Genebank) BX647357(IDS, Iduronate 2-sulfatase(Hunter syndrome)), 유전자 등록번호(Genebank) AY923172(KLK13, Kallikrein 13), 유전자 등록번호(Genebank) AK023137(MGAT4B, Mannosyl(alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B), 유전자 등록번호(Genebank) NM_024864(FLJ22578, Mitochondrial rRNA methyltransferase 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) NM_153006(NAGS, N-acetylglutamate synthase), 유전자 등록번호(Genebank) NM_020230(PPAN, Peter pan homolog(Drosophila)), 유전자 등록번호(Genebank) BC017045(PYGB, Phosphorylase, glycogen; brain), 유전자 등록번호(Genebank) NM_005401(PTPN14, Protein tyrosine phosphatase, non-receptor type 14), 유전자 등록번호(Genebank) AF290614(PTPN23, Protein tyrosine phosphatase, non-receptor type 23), 유전자 등록번호(Genebank) BX648253(PTPN3, Protein tyrosine phosphatase, non-receptor type 3), 유전자 등록번호(Genebank) NM_002840(PTPRF, Protein tyrosine phosphatase, receptor type, F), 유전자 등록번호(Genebank) D15049(PTPRH, Protein tyrosine phosphatase, receptor type, H), 유전자 등록번호(Genebank) AF348492(RBAF600, Retinoblastoma-associated factor 600), 유전자 등록번 호(Genebank) BM926478(RBP1, Retinol binding protein 1, cellular), 유전자 등록번호(Genebank) AB209196(RNH, Ribonuclease/angiogenin inhibitor 1), 유전자 등록번호(Genebank) CR619918(RPL18A, Ribosomal protein L18a), 유전자 등록번호(Genebank) BM553074(RPS15A, Ribosomal protein S15a), 유전자 등록번호(Genebank) CD387408(RPS28, Ribosomal protein S28), 유전자 등록번호(Genebank) CR749837(RPS7, Ribosomal protein S7), 유전자 등록번호(Genebank) BM805682(EEF1D, Similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein), 유전자 등록번호(Genebank) XM_069734(LOC136143, Similar to ribosomal protein L18; 60S ribosomal protein L18), 유전자 등록번호(Genebank) BG186194(RPS24, Similar to ribosomal protein S24), 유전자 등록번호(Genebank) AB037719(SSH1, Slingshot homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_005415(SLC20A1, Solute carrier family 20(phosphate transporter), member 1), 유전자 등록번호(Genebank) BF680536(SAT, Spermidine/spermine N1-acetyltransferase), 유전자 등록번호(Genebank) AK127286(SMOX, Spermine oxidase), 유전자 등록번호(Genebank) NM_005877(SF3A1, Splicing factor 3a, subunit 1, 120kDa), 유전자 등록번호(Genebank) AF082557(TNKS, Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase), 유전자 등록번호(Genebank) BC002856(TXNDC11, Thioredoxin domain containing 11) 유전자 등록번호(Genebank) NM_017722(FLJ20244, TRM1 tRNA methyltransferase 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) AK023077(USP36, Ubiquitin specific peptidase 36), 유전자 등록번호(Genebank) NM_080605(B3GALT6, UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6), 유전자 등록번호(Genebank) AY358955(B3GNT3, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3), 유전자 등록번호(Genebank) AK074143(UAP1L1, UDP-N-acteylglucosamine pyrophosphorylase 1-like 1), 유전자 등록번호(Genebank) C007348(UPP1, Uridine phosphorylase 1), 유전자 등록번호(Genebank) BC047030(UPP1, Uridine phosphorylase 1), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) BU945318(MT2A, Hypothetical gene supported by X97260; BC070289), 유전자 등록번호(Genebank) BX537968(LOC51149, Hypothetical LOC51149), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) XM_371474(PLXNB2, Plexin B2), 유전자 등록번호(Genebank) BC050636(FLJ14249, HS1-binding protein 3), 유전자 등록번호(Genebank) NM_004699(FAM50A, Family with sequence similarity 50, member A), 유전자 등록번호(Genebank) AY368150 (CHR2SYT, Family with sequence similarity 62(C2 domain containing) member B), 유전자 등록번호(Genebank) AF130077(ALB, Albumin), 유전자 등록번호(Genebank) NM_021631(FKSG2, Apoptosis inhibitor), 유전자 등록번호(Genebank) AF143236(C17orf88, Apoptosis related protein), 유전자 등록번호(Genebank) NM_001621(AHR, Aryl hydrocarbon receptor), 유전자 등록번호(Genebank) AB209123(BIRC1, Baculoviral IAP repeat-containing 1), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) NM_001167(BIRC4, Baculoviral IAP repeat-containing 4), 유전자 등록번호(Genebank) AW872828(BIRC6, Baculoviral IAP repeat-containing 6(apollon)), 유전자 등록번호(Genebank) AU146963(BCL2, B-cell CLL/lymphoma 2), 유전자 등록번호(Genebank) NM_004331(BNIP3L, BCL2/adenovirus E1B 19kDa interacting protein 3-like), 유전자 등록번호(Genebank) NM_001015049(BAG5, BCL2-associated athanogene 5), 유전자 등록번호(Genebank) NM_014739(BCLAF1, BCL2-associated transcription factor 1), 유전자 등록번호(Genebank) L33477(HSPD1, Cadherin 12, type 2(N-cadherin 2)), 유전자 등록번호(Genebank) NM_001904(CTNNB1, Catenin(cadherin-associated protein), beta 1, 88kDa), 유전자 등록번호(Genebank) NM_005894(CD5L, CD5 antigen-like(scavenger receptor cysteine rich family)), 유전자 등록번호(Genebank) AK124173(FLJ42179, CDNA FLJ42179 fis, clone THYMU2030796), 유전자 등록번호(Genebank) AB209095(CDC2L2, Cell division cycle 2-like 2(PITSLRE proteins)), 유전자 등록번호(Genebank) AK128462(CRR9, Cisplatin resistance related protein CRR9p), 유전자 등록번호(Genebank) NM_016424(CROP, Cisplatin resistance-associated overexpressed protein), 유전자 등록번호(Genebank) NM_003478(CUL5, Cullin 5), 유전자 등록번호(Genebank) NM_018947(CYCS, Cytochrome c, somatic), 유전자 등록번호(Genebank) BC048797(DFFB, DNA fragmentation factor, 40kDa, beta polypeptide(caspase-activated DNase)), 유전자 등록번호(Genebank) AB209361(FAS, Fas(TNF receptor superfamily, member 6)), 유전자 등록번호(Genebank) NM_006144(GZMA, Granzyme A(granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)), 유전자 등록번호(Genebank) BC013326(GAS2, Growth arrest-specific 2), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_005338(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) AK026927(MGC5297, Hypothetical protein MGC5297), 유전자 등록번호(Genebank) AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX648731(JMY, Junction-mediating and regulatory protein), 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) NM_000314(PTEN, Phosphatase and tensin homolog(mutated in multiple advanced cancers 1)), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) BX537500(PDCD4, Programmed cell death 4(neoplastic transformation inhibitor)), 유전자 등록번호(Genebank) NM_013374(PDCD6IP, Programmed cell death 6 interacting protein), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) CR621593(PRG2, Proteoglycan 2, bone marrow(natural killer cell activator, eosinophil granule major basic protein)), 유전자 등록번호(Genebank) BC041849(ROCK1, Rho-associated, coiled-coil containing protein kinase 1), 유전자 등록번호(Genebank) NM_000582(SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)), 유전자 등록번호(Genebank) BC039110(SMNDC1, Survival motor neuron domain containing 1), 유전자 등록번호(Genebank) AB209211(TIA1, TIA1 cytotoxic granule-associated RNA binding protein), 유전자 등록번호(Genebank) AF520785(TNFSF15, Tumor necrosis factor(ligand) superfamily, member 15), 유전자 등록번호(Genebank) NM_002546(TNFRSF11B, Tumor necrosis factor receptor superfamily, member 11b(osteoprotegerin)), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) AB209534(TRA1, Tumor rejection antigen(gp96) 1), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) AB096256(UNC5B, Unc-5 homolog B(C. elegans)), 유전자 등록번호(Genebank) AF055634(UNC5C, Unc-5 homolog C(C. elegans)), 유전자 등록번호(Genebank) AK122953(VDAC1, Voltage-dependent anion channel 1), 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) BC016344(ACPP, Acid phosphatase, prostate), 유전자 등록번호(Genebank) BM921310(ANAPC10, Anaphase promoting complex subunit 10), 유전자 등록번호(Genebank) NM_153186(ANKRD15, Ankyrin repeat domain 15), 유전자 등록번호(Genebank) AY367065(ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)), 유전자 등록번호(Genebank) NM_004071(CLK1, CDC-like kinase 1), 유전자 등록번호(Genebank) CR933728(CDC2 Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_044472(CDC42, Cell division cycle 42(GTP binding protein, 25kDa)), 유전자 등록번호(Genebank) NM_004365(CETN3, Centrin, EF-hand protein, 3(CDC31 homolog, yeast)), 유전자 등록번호(Genebank) NM_016343(CENPF, Centromere protein F, 350/400ka(mitosin)), 유전자 등록번호(Genebank) BC050310(C10orf9, Chromosome 10 open reading frame 9), 유전자 등록번호(Genebank) NM_016446(C9orf127, Chromosome 9 open reading frame 127), 유전자 등록번호(Genebank) AY257469(CIT, Citron(rho-interacting, serine/threonine kinase 21)), 유전자 등록번호(Genebank) NM_001761(CCNF, Cyclin F), 유전자 등록번호(Genebank) NM_004354(CCNG2, Cyclin G2), 유전자 등록번호(Genebank) NM_004064(CDKN1B, Cyclin-dependent kinase inhibitor 1B(p27, Kip1)), 유전자 등록번호(Genebank) NM_007068(DMC1, DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination(yeast)), 유전자 등록번호(Genebank) AK025142(BPA, dystonin), 유전자 등록번호(Genebank) NM_001950(E2F4, E2F transcription factor 4, p107/p130-binding), 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) AJ245671(EGFL6, EGF-like-domain, multiple 6),전자 등록번호(Genebank) NM_004450(ERH, Enhancer of rudimentary homolog(Drosophila)), 유전자 등록번호(Genebank) AL832041(ESCO1, Establishment of cohesion 1 homolog 1(S. cerevisiae)), 유전자 등록번호(Genebank) AL832666(ESCO2, Establishment of cohesion 1 homolog 2(S. cerevisiae)), 유전자 등록번호(Genebank) AK126048(FLJ44060, FLJ44060 protein), 유전자 등록번호(Genebank) BI494022(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) NM_014707(HDAC9, Histone deacetylase 9), 유전자 등록번호(Genebank) BC067253(FLJ40432, Hypothetical protein FLJ40432), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) BC040410(MAPRE1, Microtubule-associated protein, RP/EB family, member 1), 유 전자 등록번호(Genebank) AB033337(MPHOSPH1, M-phase phosphoprotein 1), 유전자 등록번호(Genebank) L20321(NEK4, NIMA(never in mitosis gene a)-related kinase 4), 유전자 등록번호(Genebank) AJ627032(NIPBL, Nipped-B homolog(Drosophila)), 유전자 등록번호(Genebank) AL575067(NUDC, Nuclear distribution gene C homolog(A. nidulans)), 유전자 등록번호(Genebank) NM_003884(PCAF, P300/CBP-associated factor), 유전자 등록번호(Genebank) AL833922(PAPD5, PAP associated domain containing 5), 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_016205(PDGFC, Platelet derived growth factor C), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa), 유전자 등록번호(Genebank) NM_006259(PRKG2, Protein kinase, cGMP-dependent, type II), 유전자 등록번호(Genebank) NM_002709(PPP1CB, Protein phosphatase 1, catalytic subunit, beta isoform), 유전자 등록번호(Genebank) NM_003463(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BX647606(PTMA, Prothymosin, alpha(gene sequence 28)), 유전자 등록번호(Genebank) BC068483(RINT-1, Rad50-interacting protein 1), 유전자 등록번호(Genebank) NM_006325(RAN, RAN, member RAS oncogene family), 유전자 등록번호(Genebank) NM_213590(RFP2, Ret finger protein 2), 유전자 등록번호(Genebank) NM_006910(RBBP6, Retinoblastoma binding protein 6), 유전자 등록번호(Genebank) BC060806(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) BX648668(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) AB208875(SEPT10, Septin 10), 유전자 등록번호(Genebank) AB209677(SEPT7, Septin 7), 유전자 등록번호(Genebank) BX649128(SESN3, Sestrin 3), 유전자 등록번호(Genebank) XM_497098(LOC441488, Similar to Transcription factor Dp-1(E2F dimerization partner 1)(DRTF1-polypeptide-1)(DRTF1)), 유전자 등록번호(Genebank) AK131071(SLC31A2, Solute carrier family 31(copper transporters), member 2), 유전자 등록번호(Genebank) NM_006930(SKP1A, S-phase kinase-associated protein 1A(p19A)), 유전자 등록번호(Genebank) NM_006542(SPHAR, S-phase response(cyclin-related)), 유전자 등록번호(Genebank) BX647885(STMN1, Stathmin 1/oncoprotein 18), 유전자 등록번호(Genebank) NM_014574(STRN3, Striatin, calmodulin binding protein 3), 유전자 등록번호(Genebank) NM_003176(SYCP1, Synaptonemal complex protein 1), 유전자 등록번호(Genebank) BM674777(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_007375(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_006701(TXNL4A, Thioredoxin-like 4A), 유전자 등록번호(Genebank) NM_030756(TCF7L2, Transcription factor 7-like 2(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) NM_000368(TSC1, Tuberous sclerosis 1), 유전자 등록번호(Genebank) NM_006826(YWHAQ, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide), 유전자 등록번호(Genebank) NM_001032410(USP16, Ubiquitin specific peptidase 16), 유전자 등록번호(Genebank) AK095164(KRAS2, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_138271(ATRX, Alpha thalassemia/mental retardation syndrome X-linked(RAD54 homolog, S. cerevisiae)), 유전자 등록번호(Genebank) AK025738(ASF1A, ASF1 anti-silencing function 1 homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) AK125915(CRY1, Cryptochrome 1(photolyase-like)), 유전자 등록번호(Genebank) S62138(DDIT3, DNA-damage-inducible transcript 3), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) CR936783(FLJ40869, Hypothetical protein LOC284952), 유전자 등록번호(Genebank) NM_002431(MNAT1, Menage a trois 1(CAK assembly factor)), 유전자 등록번호(Genebank) BC032617(POLI, Polymerase(DNA directed) iota), 유전자 등록번호(Genebank) NM_002690(POLB, Polymerase(DNA directed), beta), 유전자 등록번호(Genebank) AK025631(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) BC038996(PMS2L1, Postmeiotic segregation increased 2-like 1), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) NM_020165(RAD18, RAD18 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) NM_152442(RAD9B, RAD9 homolog B(S. cerevisiae)), 유전 자 등록번호(Genebank) NM_018151(RIF1, RAP1 interacting factor homolog(yeast)), 유전자 등록번호(Genebank) AI281523(SFPQ, Splicing factor proline/glutamine-rich(polypyrimidine tract binding protein associated)), 유전자 등록번호(Genebank) AK057830(TOM1L2, Target of myb1-like 2(chicken)), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) NM_001071(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) AK094617(UBE2V2, Ubiquitin-conjugating enzyme E2 variant 2), 유전자 등록번호(Genebank) NM_003337(UBE2B, Ubiquitin-conjugating enzyme E2B(RAD6 homolog)), 유전자 등록번호(Genebank) CD013992(GSTT2, Glutathione S-transferase theta 2), 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) NM_000847(GSTA3, Glutathione S-transferase A3), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_017460(CYP3A4, Cytochrome P450, family 3, subfamily A, polypeptide 4), 유전자 등록번호(Genebank) BC039065(ADH6, Alcohol dehydrogenase 6(class V)), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) NM_000667(ADH1A, Alcohol dehydrogenase 1A(class I), alpha polypeptide), 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) NM_000690(ALDH2, Aldehyde dehydrogenase 2 family(mitochondrial)), 유전자 등록번호(Genebank) NM_000696(ALDH9A1, Aldehyde dehydrogenase 9 family, member A1), 유전자 등록번호(Genebank) AK093311(ACAA2, Acetyl-Coenzyme A acyltransferase 2(mitochondrial 3-oxoacyl-Coenzyme A thiolase)), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) NM_000016(ACADM, Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain), 유전자 등록번호(Genebank) BC033517(ACOX2, Acyl-Coenzyme A oxidase 2, branched chain), 유전자 등록번호(Genebank) Z28339(AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)), 유전자 등록번호(Genebank) NM_000384(APOB, Apolipoprotein B(including Ag(x) antigen)), 유전자 등록번호(Genebank) AF285167(ABCA1, ATP-binding cassette, sub-family A(ABC1), member 1), 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_003101(SOAT1, Sterol O-acyltransferase(acyl-Coenzyme A: cholesterol acyltransferase) 1), 유전자 등록번호(Genebank) T81314(MBTPS1, Transcribed locus), 유전자 등록번호(Genebank) NM_147156(TMEM23, Transmembrane protein 23), 유전자 등록번호(Genebank) NM_003916(AP1S2, Adaptor-related protein complex 1, sigma 2 subunit), 유전자 등록번호(Genebank) AA298150(AP3S1, Adaptor-related protein complex 3, sigma 1 subunit), 유전자 등록번호(Genebank) AL109702(AP3S2, Adaptor-related protein complex 3, sigma 2 subunit), 유전자 등록번호(Genebank) BU620136(AP4S1, Adaptor-related protein complex 4, sigma 1 subunit), 유전자 등록번호(Genebank) NM_001025595(ARFIP1, ADP-ribosylation factor interacting protein 1(arfaptin 1)), 유전자 등록번호(Genebank) NM_203437(AFTIPHILIN, Aftiphilin protein), 유전자 등록번호(Genebank) NM_006380(APPBP2, Amyloid beta precursor protein(cytoplasmic tail) binding protein 2), 유전자 등록번호(Genebank) BM683433(AP1GBP1, AP1 gamma subunit binding protein 1), 유전자 등록번호(Genebank) AK027773(APG4C, ATG4 autophagy related 4 homolog C(S. cerevisiae)), 유전자 등록번호(Genebank) AF130117(CRBN, Cereblon), 유전자 등록번호(Genebank) NM_001821(CHML, Choroideremia-like(Rab escort protein 2)), 유전자 등록번호(Genebank) AK002165(DKFZP564O123, Chromatin modifying protein 2B), 유전자 등록번호(Genebank) NM_152284(Shax3, Chromatin modifying protein 4C), 유전자 등록번호(Genebank) AW167080(SNF7DC2, Chromatin modifying protein 5), 유전자 등록번호(Genebank) BF790759(SNF7DC2, Chromatin modifying protein 5), 유전자 등록번호(Genebank) NM_018229(C14orf108, Chromosome 14 open reading frame 108), 유전자 등록번호(Genebank) AF130062(CLTC, Clathrin, heavy polypeptide(Hc)), 유전자 등록번호(Genebank) AF273058(CTAGE1, Cutaneous T-cell lymphoma-associated antigen 1), 유전자 등록번호(Genebank) AK023846(DER1, Der1-like domain family, member 1), 유전자 등록번호(Genebank) NM_145261(TIM14, DnaJ(Hsp40) homolog, subfamily C, member 19), 유전자 등록번호(Genebank) AF447177(GNG10, DnaJ-like protein), 유전자 등록번호(Genebank) NM_004125(GNG10, DnaJ-like protein), 유전자 등록번호(Genebank) NM_015171(XPO6, Exportin 6), 유전자 등록번호(Genebank) CA306634(GTF2H3, General transcription factor IIH, polypeptide 3, 34kDa), 유전자 등록번호(Genebank) M57609(GLI3, GLI-Kruppel family member GLI3(Greig cephalopolysyndactyly syndrome)), 유전자 등록번호(Genebank) BC047660(FLJ25422, Hypothetical protein FLJ25422), 유전자 등록번호(Genebank) BC035090(KPNA3, Karyopherin alpha 3(importin alpha 4)), 유전자 등록번호(Genebank) AK093917(KDELR2, KDEL(Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2), 유전자 등록번호(Genebank) NM_173827(FLJ38991, Mitochondrial COX18), 유전자 등록번호(Genebank) NM_018698(NXT2, Nuclear transport factor 2-like export factor 2), 유전자 등록번호(Genebank) BC039468(NUP50, Nucleoporin 50kDa), 유전자 등록번호(Genebank) BC032755(PEX13, Peroxisome biogenesis factor 13), 유전자 등록번호(Genebank) AK023223(RAB10, RAB10, member RAS oncogene family), 유전자 등록번호(Genebank) AL162081(RAB14, RAB14, member RAS oncogene family), 유전자 등록번호(Genebank) AB209698(RAB18, RAB18, member RAS oncogene family), 유전자 등록번호(Genebank) NM_031296(RAB33B, RAB33B, member RAS oncogene family), 유전자 등록번호(Genebank) BC014553(RAB3IP, RAB3A interacting protein(rabin3)), 유전자 등록 번호(Genebank) NM_198490(RAB43, RAB43, member RAS oncogene family), 유전자 등록번호(Genebank) NM_004162(RAB5A, RAB5A, member RAS oncogene family), 유전자 등록번호(Genebank) AL136727(RAB6C, RAB6C, member RAS oncogene family), 유전자 등록번호(Genebank) NM_016530(RAB8B, RAB8B, member RAS oncogene family), 유전자 등록번호(Genebank) NM_006267(RANBP2, RAN binding protein 2), 유전자 등록번호(Genebank) NM_020150(SARA1, SAR1 gene homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) AA418814(SEC22L1, SEC22 vesicle trafficking protein-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) AA484677(SEC22L1, SEC22 vesicle trafficking protein-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) NM_031216(SEH1L, SEH1-like(S. cerevisiae)), 유전자 등록번호(Genebank) BC064351(SRP9, Signal recognition particle 9kDa), 유전자 등록번호(Genebank) NM_005843(STAM2, Signal transducing adaptor molecule(SH3 domain and ITAM motif) 2), 유전자 등록번호(Genebank) BX648363(SNX10, Sorting nexin 10), 유전자 등록번호(Genebank) AB209439(SNX15, Sorting nexin 15), 유전자 등록번호(Genebank) NM_014758(SNX19, Sorting nexin 19), 유전자 등록번호(Genebank) NM_021249(SNX6, Sorting nexin 6), 유전자 등록번호(Genebank) NM_004782(SNAP29, Synaptosomal-associated protein, 29kDa), 유전자 등록번호(Genebank) AJ420529(STX7, Syntaxin 7), 유전자 등록번호(Genebank) BC028028(STXBP3, Syntaxin binding protein 3), 유전자 등록번호(Genebank) NM_007269(STXBP3, Syntaxin binding protein 3), 유전자 등록번호(Genebank) NM_003262(TLOC1, Translocation protein 1), 유전자 등록번호(Genebank) AK094603(FLJ37284, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590.), 유전자 등록번호(Genebank) AL832866(VPS29, Vacuolar protein sorting 29(yeast)), 유전자 등록번호(Genebank) AK092532(FLJ10979, Vacuolar protein sorting 53(yeast)), 유전자 등록번호(Genebank) NM_015336(ZDHHC17, Zinc finger, DHHC-type containing 17), 유전자 등록번호(Genebank) AB002303(ZFYVE16, Zinc finger, FYVE domain containing 16), 유전자 등록번호(Genebank) NM_007236(CHP, Calcium binding protein P22), 유전자 등록번호(Genebank) AL137653(BARS, C-terminal binding protein 1), 유전자 등록번호(Genebank) AB017363(FZD1, Frizzled homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_017412(FZD3, Frizzled homolog 3(Drosophila)), 유전자 등록번호(Genebank) AB032417(FZD4, Frizzled homolog 4(Drosophila)), 유전자 등록번호(Genebank) AK125150(MAPK8, Mitogen-activated protein kinase 8), 유전자 등록번호(Genebank) AK025758(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_000933(PLCB4, Phospholipase C, beta 4), 유전자 등록번호(Genebank) AK131561(PRKACA, Protein kinase, cAMP-dependent, catalytic, alpha), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) BC078170(WNT2, Wingless-type MMTV integration site family member 2), 유전자 등록번호(Genebank) NM_003392(WNT5A, Wingless-type MMTV integration site family, member 5A), 유전자 등록번호(Genebank) AY009401(WNT6, Wingless-type MMTV integration site family, member 6), 유전자 등록번호(Genebank) AL832664(ANP32E, Acidic(leucine-rich) nuclear phosphoprotein 32 family, member E), 유전자 등록번호(Genebank) NM_138448(ACYP2, Acylphosphatase 2, muscle type), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) NM_175873(LOC134548, Ankyrin repeat domain 43), 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) AB013380(ABCB10, ATP-binding cassette, sub-family B(MDR/TAP), member 10), 유전자 등록번호(Genebank) M75106(CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)), 유전자 등록번호(Genebank) AK131472(FLJ16640, CDNA FLJ16640 fis, clone TESTI4028938, moderately similar to Zinc finger protein 85), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) BC004543(C15orf23, Chromosome 15 open reading frame 23), 유전자 등록번호(Genebank) NM_001012507(C6orf173, Chromosome 6 open reading frame 173), 유전자 등록번호(Genebank) AK000972(C9orf40, Chromosome 9 open reading frame 40), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_018204(CKAP2, Cytoskeleton associated protein 2), 유전자 등록번호(Genebank) NM_006716(ASK, DBF4 homolog(S. cerevisiae)), 유 전자 등록번호(Genebank) BC045541(LOC200895, Dihydrofolate reductase-like 1), 유전자 등록번호(Genebank) NM_152721(DOK6, Docking protein 6), 유전자 등록번호(Genebank) NM_017645(FAM29A, Family with sequence similarity 29, member A), 유전자 등록번호(Genebank) NM_207418(MGC57827, Family with sequence similarity 72, member A), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) NM_005141(FGB, Fibrinogen beta chain), 유전자 등록번호(Genebank) AB208919(FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)), 유전자 등록번호(Genebank) NM_032117(GAJ, GAJ protein), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) AB007893(KIAA0433, Histidine acid phosphatase domain containing 1), 유전자 등록번호(Genebank) AF032862(HMMR, Hyaluronan-mediated motility receptor(RHAMM)), 유전자 등록번호(Genebank) AK123495(Q5XI42, Hypothetical gene supported by AL713796), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) AL832022(FLJ13910, Hypothetical protein FLJ13910), 유전자 등록번호(Genebank) AL832208(FLJ32312, Hypothetical protein FLJ32312), 유전자 등록번호(Genebank) AB037805(KLHL14, Kelch-like 14(Drosophila)), 유전자 등록번호(Genebank) NM_014736(KIAA0101, KIAA0101), 유전자 등록번호(Genebank) AB046861(KIAA1641, KIAA1641), 유전자 등록번호(Genebank) BC033021(LOC152831, Klotho beta), 유전자 등록번호(Genebank) NM_182551(LYCAT, Lysocardiolipin acyltransferase), 유전자 등록번호(Genebank) NM_002381(MATN3, Matrilin 3), 유전자 등록번호(Genebank) AB018342(MYO10, Myosin X), 유전자 등록번호(Genebank) BX537509(NET1, Neuroepithelial cell transforming gene 1), 유전자 등록번호(Genebank) BX537360(CPSF5, Nudix(nucleoside diphosphate linked moiety X)-type motif 21), 유전자 등록번호(Genebank) NM_033222(PSIP1, PC4 and SFRS1 interacting protein 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_176869(PPA2, Pyrophosphatase(inorganic) 2), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_004586(RPS6KA3, Ribosomal protein S6 kinase, 90kDa, polypeptide 3), 유전자 등록번호(Genebank) BC064610(SEPHS1, Selenophosphate synthetase 1), 유전자 등록번호(Genebank) AK075271(SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)), 유전자 등록번호(Genebank) XM_496355(LOC440577, Similar to nucleophosmin 1), 유전자 등록번호(Genebank) XM_371758(LOC389308, Similar to ribosomal protein L10a), 유전자 등록번호(Genebank) XM_371470(LOC388907, Similar to ribosomal protein L5; 60S ribosomal protein L5), 유전자 등록번호(Genebank) XM_495961(LOC440145, Similar to RIKEN cDNA 2410129H14), 유전자 등록번호(Genebank) XM_496301(LOC440517, Similar to zinc finger protein 91(HPF7, HTF10)), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) NM_180991(SLCO4C1, Solute carrier organic anion transporter family, member 4C1), 유전자 등록번호(Genebank) BC022255(Spc25, Spindle pole body component 25 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BM458612(THRAP6, Thyroid hormone receptor associated protein 6), 유전자 등록번호(Genebank) AI300182(PROS1, Transcribed locus, weakly similar to NP_000304.1 protein S(alpha)), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AY358727(FLJ21934, UDP glucuronosyltransferase 2 family, polypeptide A3), 유전자 등록번호(Genebank) BC035579(ZNF100, Zinc finger protein 100), 유전자 등록번호(Genebank) AB209664(ZNF195, Zinc finger protein 195), 유전자 등록번호(Genebank) AY269786(ZNF429, Zinc finger protein 429), 유전자 등록번호(Genebank) NM_003423(ZNF43, Zinc finger protein 43(HTF6)), 유전자 등록번호(Genebank) NM_016220(ZNF588, Zinc finger protein 588), 유전자 등록번호(Genebank) AK122869(LOC148213, Zinc finger protein 681), 유전자 등록번호(Genebank) AK131527(ZNF15L1, Zinc finger protein 708(KOX8)), 유전자 등록번호(Genebank) NM_003430(ZNF91, Zinc finger protein 91(HPF7, HTF10)), 유전자 등록번호(Genebank) NM_152626(ZNF92, Zinc finger protein 92(HTF12)).Genebank (Genebank) BC063507 (HSPA1B, Heat shock 70kDa protein 1B), Genebank (Genebank) NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), Genebank (Genebank) NM_033027 (AXUD1, AXIN1 up- regulated 1), Genebank AF332558 (BBC3, BCL2 binding component 3), Genebank NM_138639 (BCL2L12, BCL2-like 12 (proline rich)), Genebank AK124526 (BCAR1, Breast cancer anti-estrogen resistance 1), gene registration number (Genebank) NM_147780 (CTSB, Cathepsin B), gene registration number (Genebank) AB209095 (CDC2L2, Cell division cycle 2-like 2 (PITSLRE proteins)), gene registration number ( Genebank) AK128462 (CRR9, Cisplatin resistance related protein CRR9p), Gene Registration Number (Genebank) NM_016222 (DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41), Gene Registration Number (Genebank) NM_022105 (DATF1, Death inducer obliterator 1), Genebank AK127033 (DNM2, Dynamin 2), Genebank NM_152461 (ERN1, Endoplasmic reticulum to nucleus signaling 1), Genebank NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), Genebank NM_003897 (IER3 , Immediate early response 3), Genebank NM_003639 (IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), Genebank BX640923 (MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)), Genebank NM_002648 (PIM1, Pim-1 oncogene), Genebank NM_003311 (PHLDA2, Pleckstrin homology-like domain, family A, member 2), Gene Genebank NM_004309 (ARHGDIA, Rho GDP dissociation inhibitor (GDI) alpha), Genebank (Genebank) BC041022 (SCAND1, SCAN domain containing 1), Genebank NM_006282 (STK4, Serine / threonine kinase 4 ), Gene Registration Number (Genebank) AB005666 (S IPA1, Signal-induced proliferation-associated gene 1), Genebank NM_207111 (TRIAD3, TRIAD3 protein), Genebank AY247738 (TRIB3, Tribbles homolog 3 (Drosophila)), Genebank (Genebank) AF026071 (TNFRSF25, Tumor necrosis factor receptor superfamily, member 25), Genebank AB209485 (VGFcular Vascular Endothelial Growth Factor), Genebank (Genebank) CR606241 (ACTG1, Actin, gamma 1), Gene Registration Number ( Genebank) NM_012127 (CIZ1, CDKN1A interacting zinc finger protein 1), Genebank AK057576 (CHFR, Checkpoint with forkhead and ring finger domains), Genebank NM_005255 (GAK, Cyclin G associated kinase), gene Genebank NM_078487 (CDKN2B, Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)), Genebank NM_001007271 (DUSP13, Dual specificity phosphatase 13), Genebank AK094316 (MAD2L2, MAD2 mitotic arrest deficient-like 2 (yeast), Genebank NM_002595 (PCTK2, PCTAIRE protein kinase 2), Genebank NM_000430 (PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform b, alpha subunit 45kDa), Gene Genebank X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), Gene Registration Number (Genebank) NM_001722 (POLR3D, Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa), Gene Registration Number (Genebank) NM_002808 (PSMD2, Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2), Gene Registration Number (Genebank) BC038504 (SNF1LK, SNF1-like kinase), Gene Registration Number (Genebank) BC023552 (SFN, Stratifin), Gene Registration Genebank NM_000548 (TSC2, Tuberous sclerosis 2), Gene Registration Number (Genebank) AK223618 (ZBTB17, Zinc finger and BTB domain containing 17), Gene Registration Number (Genebank) BM556279 (EMP3, Epithelial membrane protein 3), Gene Registration Number (Genebank) AY258066 (OKL38, Pregnancy-induced growth inh ibitor), Genebank NM_001012661 (SLC3A2, Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), Genebank NM_014598 (SOCS7, Suppressor of cytokine signaling 7), Gene Genebank NM_003873 (NRP1, Neuropilin 1), Genebank (Genebank) NM_015366 (FLJ20185, Rho GTPase activating protein 8), Genebank (Genebank) AB209322 (SEMA3B, Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B), genebank (Genebank) AB209463 (CSNK1D, Casein kinase 1, delta), genebank (Genebank) NM_005228 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb) b) oncogene homolog, avian)), genebank (Genebank) BC089041 (GNA11, Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)), genebank (Genebank) NM_002224 (ITPR3, Inositol 1, 4,5-triphosphate receptor, type 3), gene accession number (Genebank) NM_012463 (ATP6V0A2, ATPase, H + transport -ing, lysosomal V0 subunit a isoform 2), Genebank BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), Genebank (Menebank) NM_000574 (DAF , Decay accelerating factor for complement (CD55, Cromer blood group system), Genebank NM_001421 (ELF4, E74-like factor 4 (ets domain transcription factor)), Genebank BG171626 (FTH1, Ferritin , heavy polypeptide 1), gene accession number (Genebank) BM905227 (FTH1, Ferritin, heavy polypeptide 1), gene accession number (Genebank) NM_001015053 (HDAC5, Histone deacetylase 5), gene accession number (Genebank) NM_003641 (IFITM1, Interferon induced transmembrane protein 1 (9-27)), Genebank AF200496 (IL1F7, Interleukin 1 family, member 7 (zeta)), Genebank NM_000641 (IL11, Interleukin 11), Gene Registry Number (Genebank) ) NM_000565 (IL6R, Interleukin 6 receptor), gene registration number ( Genebank) NM_031483 (ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse)), Gene Registration Number (Genebank) NM_001300 (KLF6, Kruppel-like factor 6), Gene Registration Number (Genebank) AB209647 (NCF2, Neutrophil cytosolic factor 2 (65kDa) , chronic granulomatous disease, autosomal 2)), Genebank NM_017670 (OTUB1, OTU domain, ubiquitin aldehyde binding 1), Genebank NM_139276 (STAT3, Signal transducer and activator of transcription 3 (acute-phase) response factor), Genebank NM_003037 (SLAMF1, Signaling lymphocytic activation molecule family member 1), Genebank AL832287 (ZAP70, Zeta-chain (TCR) associated protein kinase 70kDa), Gene accession number ( Genebank) NM_001353 (AKR1C1, Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha) -hydroxysteroid dehydrogenase)), Genebank NM_001769 (CD9, CD9 antigen (p24)), Genebank NM_005242 (F2RL1, Coagulation factor II (thrombin) receptor-like 1), Gene Registration Number (Genebank) AK095781 (CIRBP, Cold inducible RNA binding protein), Gene Registration Number (Genebank) X14789 (CRYAA, Crystallin, alpha A), Gene Registration Number (Genebank) Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), genebank NM_080927 (DCBLD2, Discoidin, CUB and LCCL domain containing 2), genebank AY253982 (GPR54, G protein-coupled receptor 54), genebank (Genebank) AF073799 (GALR3, Galanin receptor 3), gene registration number (Genebank) BI767815 (GP9, Glycoprotein IX (platelet)), gene registration number (Genebank) NM_007353 (GNA12, Guanine nucleotide binding protein (G protein) alpha 12), gene registration Genebank CR623806 (HSPA6, Heat shock 70kDa protein 6 (HSP70B ')), gene registration number ( Genebank) NM_006597 (HSPA8, Heat shock 70kDa protein 8), Genebank AK000252 (FLJ20245, Hypothetical protein FLJ20245), Genebank AK057577 (IRF3, Interferon regulatory factor 3), Genebank (Genebank) L76191 (IRAK1, Interleukin-1 receptor-associated kinase 1), Genebank BC053882 (MT1X, Metallothionein 1X), Genebank AK124709 (NDRG1, N-myc downstream regulated gene 1), Gene accession number (Genebank) NM_002658 (PLAU, Plasminogen activator, urokinase), Genebank (Genebank) U02389 (PRSS15, Protease, serine, 15), Gene accession number (Genebank) NM_005053 (RAD23A, RAD23 homolog A (S. cerevisiae)), Genebank CD357517 (Unknown, Similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U)), Genebank NM_032038 (SPINL, Spinster), Gene Registry Number ( Genebank) H18681 (C20orf139, Sulfiredoxin 1 homolog (S. cerevisiae)), Gene Registration Number (Genebank) BX648190 (WDR1, WD repeat domain 1), Gene Registration Number (Genebank) AK074035 (XAB2, XPA binding protein 2), Gene Registration Number (Genebank) NM_004364 (CEBPA, CCAAT / enhancer binding protein (C / EBP), alpha), Genebank NM_017572 (MKNK2, MAP kinase interacting serine / threonine kinase 2), Genebank Z25424 (MKNK2, MAP kinase interacting serine / threonine kinase 2), Gene Registration Number (Genebank) AB209586 (MAPK13, Mitogen-activated protein kinase 13), Gene Registration Number (Genebank) NM_030662 (MAP2K2, Mitogen-activated protein kinase kinase 2), Gene Registration Number (Genebank) AB208849 (SHC1, SHC (Src) homology 2 domain containing) transforming protein 1), genebank NM_138473 (SP1, Sp1 transcription factor), genebank X02812 (TGFB1, Transforming growth factor, beta 1 (Camurati-Engelmann disease)), gene Registration Number (Genebank) NM_002880 (RAF1, V-raf-1 murine leu kemia viral oncogene homolog 1), gene registration number (Genebank) NM_152221 (CSNK1E, Casein kinase 1, epsilon), gene registration number (Genebank) AB209210 (DVL1, Dishevelled, dsh homolog 1 (Drosophila)), gene registration number (Genebank) NM_005438 (FOSL1, FOS-like antigen 1), Genebank AF077820 (LRP5, Low density lipoprotein receptor-related protein 5), Genebank NM_033119 (NKD1, Naked cuticle homolog 1 (Drosophila)), Genebank AK090488 (PPP2R1A, Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform), Genebank AL834166 (TCF7, Transcription factor 7 (T-cell specific, HMG) -box)), Genebank AY009401 (WNT6, Wingless-type MMTV integration site family, member 6), Genebank BG649164 (PAI, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type) 1), member 1), Genebank BM913048 (TIMP1, TIMP metallopept idase inhibitor 1), gene registration number (Genebank) NM_003255 (TIMP2, TIMP metallopeptidase inhibitor 2), gene registration number (Genebank) NM_014595 (NT5C, 5 ', 3'-nucleotidase, cytosolic), gene registration number (Genebank) AY461712 ( ATP13A2, ATPase type 13A2), Gene Registration Number (Genebank) NM_018590 (GALNACT-2, Chondroitin sulfate GalNAcT-2), Gene Registration Number (Genebank) NM_080757 (C20orf127, Chromosome 20 open reading frame 127), Gene Registration Number (Genebank) X16866 (CYP2D7P1, Cytochrome P450, family 2, subfamily D, polypeptide 6), gene accession number (Genebank) NM_000782 (CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), gene accession number (Genebank) AB002454 (CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), gene accession number (Genebank) AK096809 (CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), gene accession number (Genebank) NM_000786 (CYP51A1, Cytochrome P450, family 51, subfamily A, polypeptide 1), gene registration number (Gen ebank) NM_017556 (FBLP-1, Filamin binding LIM protein 1), Genebank (Genebank) AK093560 (INPP1, Inositol polyphosphate-1-phosphatase), Genebank (Genebank) NM_005578 (LPP, LIM domain containing preferred translocation partner in lipoma), Gene Registration Number (Genebank) AK222601 (MMP10, Matrix metallopeptidase 10 (stromelysin 2)), Gene Registration Number (Genebank) NM_005947 (MT1B, Metallothionein 1B (functional)), Gene Registration Number (Genebank) BC048334 (MT1G, Metallothionein) 1G), Genebank BI488702 (MT1K, Metallothionein 1M), Genebank (Genebank) NM_182924 (MICAL-L2, MICAL-like 2), Genebank AK127759 (NDUFS7, NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20 kDa (NADH-coenzyme Q reductase)), gene registration number (Genebank) NM_203353 (PDLIM7, PDZ and LIM domain 7 (enigma)), gene registration number (Genebank) NM_002627 (PFKP, Phosphofructokinase, platelet) , Gene Registration Number (Genebank) AA862994 (S100A3, S100 calcium b inding protein A3), Genebank (Genebank) NM_003461 (ZYX, Zyxin), Genebank (Genebank) NM_019112 (ABCA7, ATP-binding cassette, sub-family A (ABC1), member 7), Genebank (Genebank) ) AB209054 (ABCB6, ATP-binding cassette, sub-family B (MDR / TAP), member 6), gene registration number (Genebank) U49248 (ABCC2, ATP-binding cassette, sub-family C (CFTR / MRP), member 2), Genebank NM_020038 (ABCC3, ATP-binding cassette, sub-family C (CFTR / MRP), member 3), Genebank BC025358 (ABCD1, ATP-binding cassette, sub-family D (ALD), member 1), Genebank NG_003992 (CLK3, CDC-like kinase 3), Genebank AK128154 (C9orf86, Chromosome 9 open reading frame 86), Genebank (Genebank) BC006404 (SKD3, ClpB caseinolytic peptidase B homolog (E. coli)), gene registration number (Genebank) BC067254 (COASY, Coenzyme A synthase), gene registration number (Genebank) NM_004398 (DDX10, DEAD (Asp-Glu-Ala-Asp) box polypeptide 10), gene registration number (Genebank) BC038417 (DHX30, DEAH (Asp-Glu-Ala-His) box polypeptide 30), gene accession number (Genebank) NM_138614 (DHX30, DEAH (Asp-Glu-Ala-His) box polypeptide 30), gene accession number (Genebank) NM_032656 (DHX37, DEAH (Asp-Glu-Ala-His) box polypeptide 37), gene accession number (Genebank) NM_020812 (DOCK6, Dedicator of cytokinesis 6), gene accession number (Genebank) NM_004431 (EPHA2, EPH receptor A2), Genebank NM_001961 (EEF2, Eukaryotic translation elongation factor 2), Genebank NM_003751 (EIF3S9, Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa), Genebank AF114818 (SIAHBP1, Fuse-binding protein-interacting repressor, Genebank NM_019096 (GTPBP2, GTP binding protein 2), Gene registration Genebank NM_006572 (GNA13, Guanine nucleotide binding protein (G protein), alpha 13), Gene Registration Number (Genebank) AK128226 (HK1, Hexokinase 1), Gene Registration Number (Genebank) BC069201 (FLJ22761, Hexokinase domain containing 1) , Gene Registration Number (Genebank) NM_006546 (IMP-1, IGF-II mRNA-binding protein 1), Gene Registration Number (Genebank) NM_015155 (KIAA0217, La ribonucleoprotein domain family, member 5), Gene Registration Number (Genebank) NM_018357 ( FLJ11196, La ribonucleoprotein domain family, member 6), Genebank AK127089 (MTHFD1L, Methylenetetrahydrofolate dehydrogenase (NADP + dependent) 1-like), Genebank (Genebank) XM_038150 (MAST3, Microtubule associated serine / threonine kinase 3) Gene Registration Number (Genebank) AB058686 (MYO15B, Myosin XVB pseudogene), Gene Registration Number (Genebank) BC027875 (MYO15B, Myosin XVB pseudogene), Gene Registration Number (Genebank) K122664 (NRBP, Nuclear receptor binding protein), Gene Registration Number (Genebank) NM_001001852 (PIM3, Pim-3 oncogene), Genebank BC094766 (PKN1, Protein kinase N1), Genebank AK094474 (RHOC, Ras homolog gene family, member C), Genebank (Genebank) NM_019034 (RHOF, Ras homolog gene family, member F (in filopodia)), gene accession number (Genebank) NM_016084 (RASD1, RAS, dexamethasone-induced 1), gene accession number (Genebank) AY369207 (RBPMS2, RNA binding protein with multiple splicing 2), Genebank BC069233 (SCYL1, SCY1-like 1 (S. cerevisiae)), Genebank Number AB209553 (STK11, Serine / threonine kinase 11), Genebank Number (Genebank) AK124047 (C20orf119, Similar to embryonic poly (A) binding protein), Genebank Number XM_496374 ( LOC440595, Similar to eukaryotic translation elongation factor 1 alpha 1), Genebank Number (Genebank) NM_005094 (SLC27A4, Solute carrier family 27 (fatty acid transporter), member 4) Genebank Number (Genebank) NM_003330 (TXNRD1, Thioredoxin reductase 1) , Gene Registration Number (Genebank) NM_025195 (TRIB1, Tribbles homolog 1 (Drosophila)), Gene Registration Number (Genebank) BC009900 (UBE1, Ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)), Gene Registration Number (Genebank) AF045458 (ULK1, Unc-51-like kinase 1 (C. elegans), Genebank X59303 (VARS2, Valyl-tRNA synthetase), Genebank (Genebank) AB209808 (AP1M1, Adaptor-related protein complex 1, mu 1 subunit), Genebank AB208804 ( AP3D1, Adaptor-related protein complex 3, delta 1 subunit, Genebank BC000786 (ARFGAP1, ADP-ribosylation factor GTPase activating protein 1), Genebank AK125277 (APG4B, ATG4 autophagy related 4 homolog B (S. cerevisiae)), Gene Registration Number (Genebank) NM_007097 (CLTB, Clathrin, light polypeptide (Lcb)), Gene Registration Number (Genebank) AK091056 (COBRA1, Cofactor of BRCA1), Gene Registration Number (Genebank) AF349676 (COG3, Component of oligomeric golgi complex 3), gene registration number (Genebank) AB002368 (XPO6, Exportin 6), gene registration number (Genebank) BX648781 (GABARAPL1, GABA (A) receptor-associated protein like 1), gene registration number (Genebank) AK123405 ( GDI1, GDP dissociation inhibitor 1), Genebank NM_004712 (HGS, Hepatocyte growth factor-regulated tyrosine kinase substrate), Genebank AK094897 (IPO4, Importin 4), Genebank L38951 ( KPNB1, Karyopherin (importin) beta 1), Gene Registration Number (Genebank) NM_002268 (KPNA4, Karyopherin alpha 4 (importin alpha 3)), Gene Registration Number (Genebank) AY014403 (KIF13A, Kinesin family member 13A), Gene Registration Number ( Genebank) NM_002867 (RAB3B, RAB3B, member RAS oncogene family), Genebank (Genebank) AK025300 (RANBP3, RAN binding protein 3), Genebank (Genebank) AB014551 (ARHGEF2, Rho / rac guanine nucleotide exchange factor (GEF) 2), Genebank (Genebank) CD049342 (RPL23, Ribosomal protein L23), Genebank NM_005843 (STAM2, Signal transducing adapter molecule (SH3 domain and ITAM motif) 2), Genebank NM_006809 (TOMM34, Translocase of outer mitochondrial membrane 34), Gene registry number (Genebank) BC047528 (TOMM40, Translocase of outer
1) 상기 바이오마커 중에서 나프탈렌의 노출에 의해 발현이 증가하는 바이오 마커 유전자는 하기와 같다: 1) Biomarker genes whose expression is increased by exposure of naphthalene in the biomarkers are as follows:
유전자 등록번호(Genebank) BC063507(HSPA1B, Heat shock 70kDa protein 1B), 유전자 등록번호(Genebank) NM_016639(TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), 유전자 등록번호(Genebank) NM_033027(AXUD1, AXIN1 up-regulated 1), 유전자 등록번호(Genebank) AF332558(BBC3, BCL2 binding component 3), 유전자 등록번호(Genebank) NM_138639(BCL2L12, BCL2-like 12(proline rich)), 유전자 등록번호(Genebank) AK124526(BCAR1, Breast cancer anti-estrogen resistance 1), 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) AB209095(CDC2L2, Cell division cycle 2-like 2(PITSLRE proteins)), 유전자 등록번호(Genebank) AK128462(CRR9, Cisplatin resistance related protein CRR9p), 유전자 등록번호(Genebank) NM_016222(DDX41, DEAD(Asp-Glu-Ala-Asp) box polypeptide 41), 유전자 등록번호(Genebank) NM_022105(DATF1, Death inducer-obliterator 1), 유전자 등록번호(Genebank) AK127033(DNM2, Dynamin 2), 유전자 등록번호(Genebank) NM_152461(ERN1, Endoplasmic reticulum to nucleus signalling 1), 유전자 등록번호(Genebank) NM_003806(HRK, Harakiri, BCL2 interacting protein(contains only BH3 domain)), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) NM_003639(IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), 유전자 등록번호(Genebank) BX640923(MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein(mouse)), 유전자 등록번호(Genebank) NM_002648(PIM1, Pim-1 oncogene), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_004309(ARHGDIA, Rho GDP dissociation inhibitor(GDI) alpha), 유전자 등록번호(Genebank) BC041022(SCAND1, SCAN domain containing 1), 유전자 등록번호(Genebank) NM_006282(STK4, Serine/threonine kinase 4), 유전자 등록번호(Genebank) AB005666(SIPA1, Signal-induced proliferation-associated gene 1), 유전자 등록번호(Genebank) NM_207111(TRIAD3, TRIAD3 protein), 유전자 등록번호(Genebank) AY247738(TRIB3, Tribbles homolog 3(Drosophila)), 유전자 등록번호(Genebank) AF026071(TNFRSF25, Tumor necrosis factor receptor superfamily, member 25), 유전자 등록번호(Genebank) AB209485(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) CR606241(ACTG1, Actin, gamma 1), 유전자 등록번호(Genebank) NM_012127(CIZ1, CDKN1A interacting zinc finger protein 1), 유전자 등록번호(Genebank) AK057576(CHFR, Checkpoint with forkhead and ring finger domains), 유전자 등록번호(Genebank) NM_005255(GAK, Cyclin G associated kinase), 유전자 등록번호(Genebank) NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) AK094316(MAD2L2, MAD2 mitotic arrest deficient-like 2(yeast)), 유전자 등록번호(Genebank) NM_002595(PCTK2, PCTAIRE protein kinase 2), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform b, alpha subunit 45kDa), 유전자 등록번호(Genebank) X06374(PDGFA, Platelet-derived growth factor alpha polypeptide), 유전자 등록번호(Genebank) NM_001722(POLR3D, Polymerase(RNA) III(DNA directed) polypeptide D, 44kDa), 유전자 등록번호(Genebank) NM_002808(PSMD2, Proteasome(prosome, macropain) 26S subunit, non-ATPase, 2), 유전자 등록번호(Genebank) BC038504(SNF1LK, SNF1-like kinase), 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) NM_000548(TSC2, Tuberous sclerosis 2), 유전자 등록번호(Genebank) AK223618(ZBTB17, Zinc finger and BTB domain containing 17), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) AY258066(OKL38, Pregnancy-induced growth inhibitor), 유전자 등록번호(Genebank) NM_001012661(SLC3A2, Solute carrier family 3(activators of dibasic and neutral amino acid transport), member 2), 유전자 등록번호(Genebank) NM_014598(SOCS7, Suppressor of cytokine signaling 7), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) NM_015366(FLJ20185, Rho GTPase activating protein 8), 유전자 등록번호(Genebank) AB209322(SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted,(semaphorin) 3B), 유전자 등록번호(Genebank) AB209463(CSNK1D, Casein kinase 1, delta), 유전자 등록번호(Genebank) NM_005228(EGFR, Epidermal growth factor receptor(erythroblastic leukemia viral(v-erb-b) oncogene homolog, avian)), 유전자 등록번호(Genebank) BC089041(GNA11, Guanine nucleotide binding protein(G protein), alpha 11(Gq class)), 유전자 등록번호(Genebank) NM_002224(ITPR3, Inositol 1,4,5-triphosphate receptor, type 3), 유전자 등록번호(Genebank) NM_012463(ATP6V0A2, ATPase, H+transport -ing, lysosomal V0 subunit a isoform 2), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) NM_000574(DAF, Decay accelerating factor for complement(CD55, Cromer blood group system)), 유전자 등록번호(Genebank) NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), 유전자 등록번호(Genebank) BG171626(FTH1, Ferritin, heavy polypeptide 1), 유전자 등록번호(Genebank) BM905227(FTH1, Ferritin, heavy polypeptide 1), 유전자 등록번호(Genebank) NM_001015053(HDAC5, Histone deacetylase 5), 유전자 등록번호(Genebank) NM_003641(IFITM1, Interferon induced transmembrane protein 1(9-27)), 유전자 등록번호(Genebank) AF200496(IL1F7, Interleukin 1 family, member 7(zeta)), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) NM_000565(IL6R, Interleukin 6 receptor), 유전자 등록번호(Genebank) NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)), 유전자 등록번호(Genebank) NM_001300(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), 유전자 등록번호(Genebank) NM_017670(OTUB1, OTU domain, ubiquitin aldehyde binding 1), 유전자 등록번호(Genebank) NM_139276(STAT3, Signal transducer and activator of transcription 3(acute-phase response factor)), 유전자 등록번호(Genebank) NM_003037(SLAMF1, Signaling lymphocytic activation molecule family member 1), 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) NM_001353(AKR1C1, Aldo-keto reductase family 1, member C1(dihydrodiol dehydrogenase 1; 20-alpha(3-alpha)-hydroxysteroid dehydrogenase)), 유전자 등록번호(Genebank) NM_001769(CD9, CD9 antigen(p24)), 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK095781(CIRBP, Cold inducible RNA binding protein), 유전자 등록번호(Genebank) X14789(CRYAA, Crystallin, alpha A), 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_080927(DCBLD2, Discoidin, CUB and LCCL domain containing 2), 유전자 등록번호(Genebank) AY253982(GPR54, G protein-coupled receptor 54), 유전자 등록번호(Genebank) AF073799(GALR3, Galanin receptor 3), 유전자 등록번호(Genebank) BI767815(GP9, Glycoprotein IX(platelet)), 유전자 등록번호(Genebank) NM_007353(GNA12, Guanine nucleotide binding protein(G protein) alpha 12), 유전자 등록번호(Genebank) CR623806(HSPA6, Heat shock 70kDa protein 6(HSP70B')), 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK000252(FLJ20245, Hypothetical protein FLJ20245), 유전자 등록번호(Genebank) AK057577(IRF3, Interferon regulatory factor 3), 유전자 등록번호(Genebank) L76191(IRAK1, Interleukin-1 receptor-associated kinase 1), 유전자 등록번호(Genebank) BC053882(MT1X, Metallothionein 1X), 유전자 등록번호(Genebank) AK124709(NDRG1, N-myc downstream regulated gene 1), 유전자 등록번호(Genebank) NM_002658(PLAU, Plasminogen activator, urokinase), 유전자 등록번호(Genebank) U02389(PRSS15, Protease, serine, 15), 유전자 등록번호(Genebank) NM_005053(RAD23A, RAD23 homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) CD357517(Unknown, Similar to Interferon-induced transmembrane protein 3(Interferon-inducible protein 1-8U)), 유전자 등록번호(Genebank) NM_032038(SPINL, Spinster), 유전자 등록번호(Genebank) H18681(C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BX648190(WDR1, WD repeat domain 1), 유전자 등록번호(Genebank) AK074035(XAB2, XPA binding protein 2), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_017572(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_030662(MAP2K2, Mitogen-activated protein kinase kinase 2), 유전자 등록번호(Genebank) AB208849(SHC1, SHC(Src homology 2 domain containing) transforming protein 1), 유전자 등록번호(Genebank) NM_138473(SP1, Sp1 transcription factor), 유전자 등록번호(Genebank) X02812(TGFB1, Transforming growth factor, beta 1(Camurati-Engelmann disease)), 유전자 등록번호(Genebank) NM_002880(RAF1, V-raf-1 murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_152221(CSNK1E, Casein kinase 1, epsilon), 유전자 등록번호(Genebank) AB209210(DVL1, Dishevelled, dsh homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) AF077820(LRP5, Low density lipoprotein receptor-related protein 5), 유전자 등록번호(Genebank) NM_033119(NKD1, Naked cuticle homolog 1(Drosophila)), 유전자 등록번호(Genebank) AK090488(PPP2R1A, Protein phosphatase 2(formerly 2A), regulatory subunit A(PR 65), alpha isoform), 유전자 등록번호(Genebank) AL834166(TCF7, Transcription factor 7(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) AY009401(WNT6, Wingless-type MMTV integration site family, member 6), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003255(TIMP2, TIMP metallopeptidase inhibitor 2), 유전자 등록번호(Genebank) NM_014595(NT5C, 5', 3'-nucleotidase, cytosolic), 유전자 등록번호(Genebank) AY461712(ATP13A2, ATPase type 13A2), 유전자 등록번호(Genebank) NM_018590(GALNACT-2, Chondroitin sulfate GalNAcT-2), 유전자 등록번호(Genebank) NM_080757(C20orf127, Chromosome 20 open reading frame 127), 유전자 등록번호(Genebank) X16866(CYP2D7P1, Cytochrome P450, family 2, subfamily D, polypeptide 6), 유전자 등록번호(Genebank) NM_000782(CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), 유전자 등록번호(Genebank) NM_000786(CYP51A1, Cytochrome P450, family 51, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_017556(FBLP-1, Filamin binding LIM protein 1), 유전자 등록번호(Genebank) AK093560(INPP1, Inositol polyphosphate-1-phosphatase), 유전자 등록번호(Genebank) NM_005578(LPP, LIM domain containing preferred translocation partner in lipoma), 유전자 등록번호(Genebank) AK222601(MMP10, Matrix metallopeptidase 10(stromelysin 2)), 유전자 등록번호(Genebank) NM_005947(MT1B, Metallothionein 1B(functional)), 유전자 등록번호(Genebank) BC048334(MT1G, Metallothionein 1G), 유전자 등록번호(Genebank) BI488702(MT1K, Metallothionein 1M), 유전자 등록번호(Genebank) NM_182924(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK127759(NDUFS7, NADH dehydrogenase(ubiquinone) Fe-S protein 7, 20kDa(NADH- coenzyme Q reductase)), 유전자 등록번호(Genebank) NM_203353(PDLIM7, PDZ and LIM domain 7(enigma)), 유전자 등록번호(Genebank) NM_002627(PFKP, Phosphofructokinase, platelet), 유전자 등록번호(Genebank) AA862994(S100A3, S100 calcium binding protein A3), 유전자 등록번호(Genebank) NM_003461(ZYX, Zyxin), 유전자 등록번호(Genebank) NM_019112(ABCA7, ATP-binding cassette, sub-family A(ABC1), member 7), 유전자 등록번호(Genebank) AB209054(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), 유전자 등록번호(Genebank) NM_020038(ABCC3, ATP-binding cassette, sub-family C(CFTR/MRP), member 3), 유전자 등록번호(Genebank) BC025358(ABCD1, ATP-binding cassette, sub-family D(ALD), member 1), 유전자 등록번호(Genebank) NM_003992(CLK3, CDC-like kinase 3), 유전자 등록번호(Genebank) AK128154(C9orf86, Chromosome 9 open reading frame 86), 유전자 등록번호(Genebank) BC006404(SKD3, ClpB caseinolytic peptidase B homolog(E. coli)), 유전자 등록번호(Genebank) BC067254(COASY, Coenzyme A synthase), 유전자 등록번호(Genebank) NM_004398(DDX10, DEAD(Asp-Glu-Ala-Asp) box polypeptide 10), 유전자 등록번호(Genebank) BC038417(DHX30, DEAH(Asp-Glu-Ala-His) box polypeptide 30), 유전자 등록번호(Genebank) NM_138614(DHX30, DEAH(Asp-Glu-Ala-His) box polypeptide 30), 유전자 등록번호(Genebank) NM_032656(DHX37, DEAH(Asp-Glu-Ala-His) box polypeptide 37), 유전자 등록번호(Genebank) NM_020812(DOCK6, Dedicator of cytokinesis 6), 유전자 등록번호(Genebank) NM_004431(EPHA2, EPH receptor A2), 유전자 등록번호(Genebank) NM_001961(EEF2, Eukaryotic translation elongation factor 2), 유전자 등록번호(Genebank) NM_003751(EIF3S9, Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa), 유전자 등록번호(Genebank) AF114818(SIAHBP1, Fuse-binding protein-interacting repressor), 유전자 등록번호(Genebank) NM_019096(GTPBP2, GTP binding protein 2), 유전자 등록번호(Genebank) NM_006572(GNA13, Guanine nucleotide binding protein(G protein), alpha 13), 유전자 등록번호(Genebank) AK128226(HK1, Hexokinase 1), 유전자 등록번호(Genebank) BC069201(FLJ22761, Hexokinase domain containing 1), 유전자 등록번호(Genebank) NM_006546(IMP-1, IGF-II mRNA-binding protein 1), 유전자 등록번호(Genebank) NM_015155(KIAA0217, La ribonucleoprotein domain family, member 5), 유전자 등록번호(Genebank) NM_018357(FLJ11196, La ribonucleoprotein domain family, member 6), 유전자 등록번호(Genebank) AK127089(MTHFD1L, Methylenetetrahydrofolate dehydrogenase(NADP+ dependent) 1-like), 유전자 등록번호(Genebank) XM_038150(MAST3, Microtubule associated serine/threonine kinase 3), 유전자 등록번호(Genebank) AB058686(MYO15B, Myosin XVB pseudogene), 유전자 등록번호(Genebank) BC027875(MYO15B, Myosin XVB pseudogene), 유전자 등록번호(Genebank) K122664(NRBP, Nuclear receptor binding protein), 유전자 등록번호(Genebank) NM_001001852(PIM3, Pim-3 oncogene), 유전자 등록번호(Genebank) BC094766(PKN1, Protein kinase N1), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_019034(RHOF, Ras homolog gene family, member F(in filopodia)), 유전자 등록번호(Genebank) NM_016084(RASD1, RAS, dexamethasone-induced 1), 유전자 등록번호(Genebank) AY369207(RBPMS2, RNA binding protein with multiple splicing 2), 유전자 등록번호(Genebank) BC069233(SCYL1, SCY1-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) AB209553(STK11, Serine/threonine kinase 11), 유전자 등록번호(Genebank) AK124047(C20orf119, Similar to embryonic poly(A) binding protein), 유전자 등록번호(Genebank) XM_496374(LOC440595, Similar to eukaryotic translation elongation factor 1 alpha 1), 유전자 등록번호(Genebank) NM_005094(SLC27A4, Solute carrier family 27(fatty acid transporter), member 4) 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) NM_025195(TRIB1, Tribbles homolog 1(Drosophila)), 유전자 등록번호(Genebank) BC009900(UBE1, Ubiquitin-activating enzyme E1(A1S9T and BN75 temperature sensitivity complementing)), 유전자 등록번호(Genebank) AF045458(ULK1, Unc-51-like kinase 1(C. elegans)), 유전자 등록번호(Genebank) X59303(VARS2, Valyl-tRNA synthetase), 유전자 등록번호(Genebank) AB209808(AP1M1, Adaptor-related protein complex 1, mu 1 subunit), 유전자 등록번호(Genebank) AB208804(AP3D1, Adaptor-related protein complex 3, delta 1 subunit), 유전자 등록번호(Genebank) BC000786(ARFGAP1, ADP- ribosylation factor GTPase activating protein 1), 유전자 등록번호(Genebank) AK125277(APG4B, ATG4 autophagy related 4 homolog B(S. cerevisiae)), 유전자 등록번호(Genebank) NM_007097(CLTB, Clathrin, light polypeptide(Lcb)), 유전자 등록번호(Genebank) AK091056(COBRA1, Cofactor of BRCA1), 유전자 등록번호(Genebank) AF349676(COG3, Component of oligomeric golgi complex 3), 유전자 등록번호(Genebank) AB002368(XPO6, Exportin 6), 유전자 등록번호(Genebank) BX648781(GABARAPL1, GABA(A) receptor-associated protein like 1), 유전자 등록번호(Genebank) AK123405(GDI1, GDP dissociation inhibitor 1), 유전자 등록번호(Genebank) NM_004712(HGS, Hepatocyte growth factor-regulated tyrosine kinase substrate), 유전자 등록번호(Genebank) AK094897(IPO4, Importin 4), 유전자 등록번호(Genebank) L38951(KPNB1, Karyopherin(importin) beta 1), 유전자 등록번호(Genebank) NM_002268(KPNA4, Karyopherin alpha 4(importin alpha 3)), 유전자 등록번호(Genebank) AY014403(KIF13A, Kinesin family member 13A), 유전자 등록번호(Genebank) NM_002867(RAB3B, RAB3B, member RAS oncogene family), 유전자 등록번호(Genebank) AK025300(RANBP3, RAN binding protein 3), 유전자 등록번호(Genebank) AB014551(ARHGEF2, Rho/rac guanine nucleotide exchange factor(GEF) 2), 유전자 등록번호(Genebank) CD049342(RPL23, Ribosomal protein L23), 유전자 등록번호(Genebank) NM_005843(STAM2, Signal transducing adaptor molecule(SH3 domain and ITAM motif) 2), 유전자 등록번호(Genebank) NM_006809(TOMM34, Translocase of outer mitochondrial membrane 34), 유전자 등 록번호(Genebank) BC047528(TOMM40, Translocase of outer mitochondrial membrane 40 homolog(yeast)), 유전자 등록번호(Genebank) AK056701(VPS11, Vacuolar protein sorting 11(yeast)), 유전자 등록번호(Genebank) BC042390(VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)), 유전자 등록번호(Genebank) AK095154(AES, Amino-terminal enhancer of split), 유전자 등록번호(Genebank) BC060828(ARID3A, AT rich interactive domain 3A(BRIGHT- like)), 유전자 등록번호(Genebank) NM_003670(BHLHB2, Basic helix-loop-helix domain containing, class B, 2), 유전자 등록번호(Genebank) NM_006442(DRAP1, DR1-associated protein 1(negative cofactor 2 alpha)), 유전자 등록번호(Genebank) NM_006532(ELL, Elongation factor RNA polymerase II), 유전자 등록번호(Genebank) NM_001991(EZH1, Enhancer of zeste homolog 1(Drosophila)), 유전자 등록번호(Genebank) U18018(ETV4, Ets variant gene 4(E1A enhancer binding protein, E1AF)), 유전자 등록번호(Genebank) NM_002018(FLII, Flightless I homolog(Drosophila)), 유전자 등록번호(Genebank) NM_181430(FOXK2, Forkhead box K2), 유전자 등록번호(Genebank) NM_001012426(FOXP4, Forkhead box P4), 유전자 등록번호(Genebank) BC053850(FOXQ1, Forkhead box Q1), 유전자 등록번호(Genebank) AF176422(HEY1, Hairy/enhancer-of-split related with YRPW motif 1), 유전자 등록번호(Genebank) BC078664(HMGA1, High mobility group AT-hook 1), 유전자 등록번호(Genebank) XM_379934(KIAA1718, KIAA1718 protein), 유전자 등록번호(Genebank) BC069156(LBX1, Ladybird homeobox homolog 1(Drosophila)), 유전 자 등록번호(Genebank) NM_014520(MYBBP1A, MYB binding protein(P160) 1a), 유전자 등록번호(Genebank) NM_002518(NPAS2, Neuronal PAS domain protein 2), 유전자 등록번호(Genebank) NM_001001716(NFKBIB, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta), 유전자 등록번호(Genebank) AF087856(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002653(PITX1, Paired-like homeodomain transcription factor 1), 유전자 등록번호(Genebank) NM_001003891(PCQAP, PC2(positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein), 유전자 등록번호(Genebank) NM_005035(POLRMT, Polymerase(RNA) mitochondrial(DNA directed)), 유전자 등록번호(Genebank) NM_012448(STAT5B, Signal transducer and activator of transcription 5B), 유전자 등록번호(Genebank) CR607342(RNPS1, Similar to splicing-related factor RNPS1), 유전자 등록번호(Genebank) NM_005986(SOX1, SRY(sex determining region Y)-box 1), 유전자 등록번호(Genebank) NM_003072(SMARCA4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4), 유전자 등록번호(Genebank) NM_006951(TAF5, TAF5 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 100kDa), 유전자 등록번호(Genebank) NM_152380(TBX15, T-box 15), 유전자 등록번호(Genebank) NM_016569(TBX3, T-box 3(ulnar mammary syndrome)), 유전자 등록번호(Genebank) BC006396(TLX2, T-cell leukemia, homeobox 2), 유전자 등록번호(Genebank) AF106934(THRAP5, Thyroid hormone receptor associated protein 5), 유전자 등록번호(Genebank) AF108461(UBN1, Ubinuclein 1), 유전자 등록번호(Genebank) NM_002359(MAFG, V-maf musculoaponeurotic fibrosarcoma oncogene homolog G(avian)), 유전자 등록번호(Genebank) AK092414(MAFK, V-maf musculoaponeurotic fibrosarcoma oncogene homolog K(avian)), 유전자 등록번호(Genebank) AK128553(ZZANK1, Mindbomb homolog 2(Drosophila)), 유전자 등록번호(Genebank) NM_001003694(BRPF1, Bromodomain and PHD finger containing, 1), 유전자 등록번호(Genebank) CR936799(FHL2, Four and a half LIM domains 2), 유전자 등록번호(Genebank) NM_139201(GIT2, G protein-coupled receptor kinase interactor 2), 유전자 등록번호(Genebank) AK125974(p66alpha, GATA zinc finger domain containing 2A), 유전자 등록번호(Genebank) CB050471(GLI4, GLI-Kruppel family member GLI4), 유전자 등록번호(Genebank) NM_006734(HIVEP2, Human immunodeficiency virus type I enhancer binding protein 2), 유전자 등록번호(Genebank) NM_031297(DKFZP761H1710, Hypothetical protein DKFZp761H1710), 유전자 등록번호(Genebank) NM_024671(FLJ23436, Hypothetical protein FLJ23436), 유전자 등록번호(Genebank) NM_173680(MGC33584, Hypothetical protein MGC33584), 유전자 등록번호(Genebank) NM_031918(KLF16, Kruppel-like factor 16), 유전자 등록번호(Genebank) BU163740(MKRN1, Makorin, ring finger protein, 1), 유전자 등록번호(Genebank) NM_005885(MARCH-V, Membrane-associated ring finger(C3HC4) 6), 유전자 등록번호(Genebank) AF242768(LOC51333, Mesenchymal stem cell protein DSC43), 유전자 등록번호(Genebank) NM_020774(MIB1, Mindbomb homolog 1(Drosophila)), 유전자 등록번호(Genebank) AJ007041(MLL4, Myeloid/lymphoid or mixed-lineage leukemia 4), 유전자 등록번호(Genebank) BF206103(ZNF286, Peroxisome proliferative activated receptor, alpha-like), 유전자 등록번호(Genebank) BC008834(PHF1, PHD finger protein 1), 유전자 등록번호(Genebank) D87076(PHF15, PHD finger protein 15), 유전자 등록번호(Genebank) NM_020122(KCMF1, Potassium channel modulatory factor 1), 유전자 등록번호(Genebank) NM_145214(TRIM11, Tripartite motif-containing 11), 유전자 등록번호(Genebank) NM_033452(TRIM47, Tripartite motif-containing 47), 유전자 등록번호(Genebank) AF281046(TRIM8, Tripartite motif-containing 8), 유전자 등록번호(Genebank) BC004256(ZNF259, Zinc finger protein 259), 유전자 등록번호(Genebank) CR597101(ZFP36, Zinc finger protein 36, C3H type, homolog(mouse)), 유전자 등록번호(Genebank) NM_198055(ZNF42, Zinc finger protein 42(myeloid-specific retinoic acid-responsive)), 유전자 등록번호(Genebank) BC071620(ZNF581, Zinc finger protein 581), 유전자 등록번호(Genebank) BM544755(ZNF593, Zinc finger protein 593), 유전자 등록번호(Genebank) AK024487(ZNF598, Zinc finger protein 598), 유전자 등록번호(Genebank) BC089449(ZEC, Zinc finger protein 628), 유전자 등록번호(Genebank) NM_153813(ZFPM1, Zinc finger protein, multitype 1), 유전자 등록번호(Genebank) BM451410(ZA20D2, Zinc finger, A20 domain containing 2), 유전자 등록번호(Genebank) BX648551(ZA20D2, Zinc finger, A20 domain containing 2), 유전자 등록번호(Genebank) BC006340(ZCCHC2, Zinc finger, CCHC domain containing 2), 유전자 등록번호(Genebank) BC053544(ZDHHC8, Zinc finger, DHHC-type containing 8), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BQ939577(AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)), 유전자 등록번호(Genebank) AB045292(TMEM8, Transmembrane protein 8(five membrane-spanning domains)), 유전자 등록번호(Genebank) NM_012088(PGLS, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) NM_184041(ALDOA, Aldolase A, fructose-bisphosphate), 유전자 등록번호(Genebank) NM_000402(G6PD, Glucose-6-phosphate dehydrogenase), 유전자 등록번호(Genebank) NM_006715(MAN2C1, Mannosidase, alpha, class 2C, member 1), 유전자 등록번호(Genebank) CR597860(C19orf27, Chromosome 19 open reading frame 27), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) BC042195(MT, Malonyl-CoA:acyl carrier protein transacylase, mitochondrial), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) AK057049(PTGES2, Prostaglandin E synthase 2), 유전자 등록번호(Genebank) AB046825(GBA2, Glucosidase, beta(bile acid) 2), 유전자 등록번호(Genebank) BC033110(HSD17B1, Hydroxysteroid(17-beta) dehydrogenase 1), 유전자 등록번호(Genebank) BC050553(NTE, Neuropathy target esterase), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) NM_005028(PIP5K2A, Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha), 유전자 등록번호(Genebank) BC007612(PSAP, Prosaposin(variant Gaucher disease and variant metachromatic leukodystrophy)), 유전자 등록번호(Genebank) BC087612(SBF1, SET binding factor 1), 유전자 등록번호(Genebank) BQ683841(S100A11, S100 calcium binding protein A11(calgizzarin)), 유전자 등록번호(Genebank) CK000930(HIST1H2AI, Histone 1, H2ai), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) BC069193(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK223291(MMP3, Matrix metallopeptidase 3(stromelysin 1, progelatinase)), 유전자 등록번호(Genebank) NM_178819(DKFZp586M1819, 1-acylglycerol-3-phosphate O-acyltransferase 6(lysophosphatidic acid acyltransferase, zeta)), 유전자 등록번호(Genebank) NM_018694(ARL6IP4, ADP-ribosylation-like factor 6 interacting protein 4), 유전자 등록번호(Genebank) BC014895(MGC10204, Aldehyde dehydrogenase 16 family, member A1), 유전자 등록번호(Genebank) NM_032468(ASPH, Aspartate beta-hydroxylase), 유전자 등록번 호(Genebank) BC008751(CAPN1, Calpain 1,(mu/I) large subunit), 유전자 등록번호(Genebank) AK128552(CAPN10, Calpain 10), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) NM_001903(CTNNA1, Catenin(cadherin-associated protein), alpha 1, 102kDa), 유전자 등록번호(Genebank) BC067289(CTSL2, Cathepsin L2), 유전자 등록번호(Genebank) NM_015151(C21orf106, Chromosome 21 open reading frame 106), 유전자 등록번호(Genebank) NM_031434(C7orf21, Chromosome 7 open reading frame 21), 유전자 등록번호(Genebank) NM_001303(COX10, COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase(yeast)), 유전자 등록번호(Genebank) BP317375(COX6A2, Cytochrome c oxidase subunit VIa polypeptide 2), 유전자 등록번호(Genebank) NM_001355(DDT, D-dopachrome tautomerase), 유전자 등록번호(Genebank) NM_032482(DOT1L, DOT1-like, histone H3 methyltransferase(S. cerevisiae)), 유전자 등록번호(Genebank) NM_004419(DUSP5, Dual specificity phosphatase 5), 유전자 등록번호(Genebank) AB210013(EIF4G1, Eukaryotic translation initiation factor 4 gamma, 1), 유전자 등록번호(Genebank) NM_020158(EXOSC5, Exosome component 5), 유전자 등록번호(Genebank) NM_178225(FBXW5, F-box and WD-40 domain protein 5), 유전자 등록번호(Genebank) NM_058229(FBXO32, F-box protein 32), 유전자 등록번호(Genebank) AB209592(GMPPA, GDP-mannose pyrophosphorylase A), 유전자 등록번호(Genebank) AJ002231(GNPDA1, Glucosamine-6-phosphate deaminase 1), 유전자 등록번 호(Genebank) AK094940(GCLC, Glutamate-cysteine ligase, catalytic subunit), 유전자 등록번호(Genebank) NM_005318(H1F0, H1 histone family, member 0), 유전자 등록번호(Genebank) NM_004639(BAT3, HLA-B associated transcript 3), 유전자 등록번호(Genebank) NM_032717(MGC11324, Hypothetical protein MGC11324), 유전자 등록번호(Genebank) BX647357(IDS, Iduronate 2-sulfatase(Hunter syndrome)), 유전자 등록번호(Genebank) AY923172(KLK13, Kallikrein 13), 유전자 등록번호(Genebank) AK023137(MGAT4B, Mannosyl(alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B), 유전자 등록번호(Genebank) NM_024864(FLJ22578, Mitochondrial rRNA methyltransferase 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) NM_153006(NAGS, N-acetylglutamate synthase), 유전자 등록번호(Genebank) NM_020230(PPAN, Peter pan homolog(Drosophila)), 유전자 등록번호(Genebank) BC017045(PYGB, Phosphorylase, glycogen; brain), 유전자 등록번호(Genebank) NM_005401(PTPN14, Protein tyrosine phosphatase, non-receptor type 14), 유전자 등록번호(Genebank) AF290614(PTPN23, Protein tyrosine phosphatase, non-receptor type 23), 유전자 등록번호(Genebank) BX648253(PTPN3, Protein tyrosine phosphatase, non-receptor type 3), 유전자 등록번호(Genebank) NM_002840(PTPRF, Protein tyrosine phosphatase, receptor type, F), 유전자 등록번호(Genebank) D15049(PTPRH, Protein tyrosine phosphatase, receptor type, H), 유전자 등록번호(Genebank) AF348492(RBAF600, Retinoblastoma-associated factor 600), 유전자 등록번 호(Genebank) BM926478(RBP1, Retinol binding protein 1, cellular), 유전자 등록번호(Genebank) AB209196(RNH, Ribonuclease/angiogenin inhibitor 1), 유전자 등록번호(Genebank) CR619918(RPL18A, Ribosomal protein L18a), 유전자 등록번호(Genebank) BM553074(RPS15A, Ribosomal protein S15a), 유전자 등록번호(Genebank) CD387408(RPS28, Ribosomal protein S28), 유전자 등록번호(Genebank) CR749837(RPS7, Ribosomal protein S7), 유전자 등록번호(Genebank) BM805682(EEF1D, Similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein), 유전자 등록번호(Genebank) XM_069734(LOC136143, Similar to ribosomal protein L18; 60S ribosomal protein L18), 유전자 등록번호(Genebank) BG186194(RPS24, Similar to ribosomal protein S24), 유전자 등록번호(Genebank) AB037719(SSH1, Slingshot homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_005415(SLC20A1, Solute carrier family 20(phosphate transporter), member 1), 유전자 등록번호(Genebank) BF680536(SAT, Spermidine/spermine N1-acetyltransferase), 유전자 등록번호(Genebank) AK127286(SMOX, Spermine oxidase), 유전자 등록번호(Genebank) NM_005877(SF3A1, Splicing factor 3a, subunit 1, 120kDa), 유전자 등록번호(Genebank) AF082557(TNKS, Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase), 유전자 등록번호(Genebank) BC002856(TXNDC11, Thioredoxin domain containing 11) 유전자 등록번호(Genebank) NM_017722(FLJ20244, TRM1 tRNA methyltransferase 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) AK023077(USP36, Ubiquitin specific peptidase 36), 유전자 등록번호(Genebank) NM_080605(B3GALT6, UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6), 유전자 등록번호(Genebank) AY358955(B3GNT3, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3), 유전자 등록번호(Genebank) AK074143(UAP1L1, UDP-N-acteylglucosamine pyrophosphorylase 1-like 1), 유전자 등록번호(Genebank) C007348(UPP1, Uridine phosphorylase 1), 유전자 등록번호(Genebank) BC047030(UPP1, Uridine phosphorylase 1), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) BU945318(MT2A, Hypothetical gene supported by X97260; BC070289), 유전자 등록번호(Genebank) BX537968(LOC51149, Hypothetical LOC51149), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) XM_371474(PLXNB2, Plexin B2), 유전자 등록번호(Genebank) BC050636(FLJ14249, HS1-binding protein 3), 유전자 등록번호(Genebank) NM_004699(FAM50A, Family with sequence similarity 50, member A), 유전자 등록번호(Genebank) AY368150(CHR2SYT, Family with sequence similarity 62(C2 domain containing) member B).Genebank (Genebank) BC063507 (HSPA1B, Heat shock 70kDa protein 1B), Genebank (Genebank) NM_016639 (TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), Genebank (Genebank) NM_033027 (AXUD1, AXIN1 up- regulated 1), Genebank AF332558 (BBC3, BCL2 binding component 3), Genebank NM_138639 (BCL2L12, BCL2-like 12 (proline rich)), Genebank AK124526 (BCAR1, Breast cancer anti-estrogen resistance 1), gene registration number (Genebank) NM_147780 (CTSB, Cathepsin B), gene registration number (Genebank) AB209095 (CDC2L2, Cell division cycle 2-like 2 (PITSLRE proteins)), gene registration number ( Genebank) AK128462 (CRR9, Cisplatin resistance related protein CRR9p), Gene Registration Number (Genebank) NM_016222 (DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41), Gene Registration Number (Genebank) NM_022105 (DATF1, Death inducer obliterator 1), Genebank AK127033 (DNM2, Dynamin 2), Genebank NM_152461 (ERN1, Endoplasmic reticulum to nucleus signaling 1), Genebank NM_003806 (HRK, Harakiri, BCL2 interacting protein (contains only BH3 domain)), Genebank NM_003897 (IER3 , Immediate early response 3), Genebank NM_003639 (IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), Genebank BX640923 (MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)), Genebank NM_002648 (PIM1, Pim-1 oncogene), Genebank NM_003311 (PHLDA2, Pleckstrin homology-like domain, family A, member 2), Gene Genebank NM_004309 (ARHGDIA, Rho GDP dissociation inhibitor (GDI) alpha), Genebank (Genebank) BC041022 (SCAND1, SCAN domain containing 1), Genebank NM_006282 (STK4, Serine / threonine kinase 4 ), Gene Registration Number (Genebank) AB005666 (S IPA1, Signal-induced proliferation-associated gene 1), Genebank NM_207111 (TRIAD3, TRIAD3 protein), Genebank AY247738 (TRIB3, Tribbles homolog 3 (Drosophila)), Genebank (Genebank) AF026071 (TNFRSF25, Tumor necrosis factor receptor superfamily, member 25), Genebank AB209485 (VGFcular Vascular Endothelial Growth Factor), Genebank (Genebank) CR606241 (ACTG1, Actin, gamma 1), Gene Registration Number ( Genebank) NM_012127 (CIZ1, CDKN1A interacting zinc finger protein 1), Genebank AK057576 (CHFR, Checkpoint with forkhead and ring finger domains), Genebank NM_005255 (GAK, Cyclin G associated kinase), gene Genebank NM_078487 (CDKN2B, Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)), Genebank NM_001007271 (DUSP13, Dual specificity phosphatase 13), Genebank AK094316 (MAD2L2, MAD2 mitotic arrest deficient-like 2 (yeast), Genebank NM_002595 (PCTK2, PCTAIRE protein kinase 2), Genebank NM_000430 (PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform b, alpha subunit 45kDa), Gene Genebank X06374 (PDGFA, Platelet-derived growth factor alpha polypeptide), Gene Registration Number (Genebank) NM_001722 (POLR3D, Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa), Gene Registration Number (Genebank) NM_002808 (PSMD2, Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2), Gene Registration Number (Genebank) BC038504 (SNF1LK, SNF1-like kinase), Gene Registration Number (Genebank) BC023552 (SFN, Stratifin), Gene Registration Genebank NM_000548 (TSC2, Tuberous sclerosis 2), Gene Registration Number (Genebank) AK223618 (ZBTB17, Zinc finger and BTB domain containing 17), Gene Registration Number (Genebank) BM556279 (EMP3, Epithelial membrane protein 3), Gene Registration Number (Genebank) AY258066 (OKL38, Pregnancy-induced growth inh ibitor), Genebank NM_001012661 (SLC3A2, Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2), Genebank NM_014598 (SOCS7, Suppressor of cytokine signaling 7), Gene Genebank NM_003873 (NRP1, Neuropilin 1), Genebank (Genebank) NM_015366 (FLJ20185, Rho GTPase activating protein 8), Genebank (Genebank) AB209322 (SEMA3B, Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B), genebank (Genebank) AB209463 (CSNK1D, Casein kinase 1, delta), genebank (Genebank) NM_005228 (EGFR, Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb) b) oncogene homolog, avian)), genebank (Genebank) BC089041 (GNA11, Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)), genebank (Genebank) NM_002224 (ITPR3, Inositol 1, 4,5-triphosphate receptor, type 3), gene accession number (Genebank) NM_012463 (ATP6V0A2, ATPase, H + transport -ing, lysosomal V0 subunit a isoform 2), Genebank BQ053419 (BATF, Basic leucine zipper transcription factor, ATF-like), Genebank (Menebank) NM_000574 (DAF , Decay accelerating factor for complement (CD55, Cromer blood group system), Genebank NM_001421 (ELF4, E74-like factor 4 (ets domain transcription factor)), Genebank BG171626 (FTH1, Ferritin , heavy polypeptide 1), gene accession number (Genebank) BM905227 (FTH1, Ferritin, heavy polypeptide 1), gene accession number (Genebank) NM_001015053 (HDAC5, Histone deacetylase 5), gene accession number (Genebank) NM_003641 (IFITM1, Interferon induced transmembrane protein 1 (9-27)), Genebank AF200496 (IL1F7, Interleukin 1 family, member 7 (zeta)), Genebank NM_000641 (IL11, Interleukin 11), Gene Registry Number (Genebank) ) NM_000565 (IL6R, Interleukin 6 receptor), gene registration number ( Genebank) NM_031483 (ITCH, Itchy homolog E3 ubiquitin protein ligase (mouse)), Gene Registration Number (Genebank) NM_001300 (KLF6, Kruppel-like factor 6), Gene Registration Number (Genebank) AB209647 (NCF2, Neutrophil cytosolic factor 2 (65kDa) , chronic granulomatous disease, autosomal 2)), Genebank NM_017670 (OTUB1, OTU domain, ubiquitin aldehyde binding 1), Genebank NM_139276 (STAT3, Signal transducer and activator of transcription 3 (acute-phase) response factor), Genebank NM_003037 (SLAMF1, Signaling lymphocytic activation molecule family member 1), Genebank AL832287 (ZAP70, Zeta-chain (TCR) associated protein kinase 70kDa), Gene accession number ( Genebank) NM_001353 (AKR1C1, Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha) -hydroxysteroid dehydrogenase)), Genebank NM_001769 (CD9, CD9 antigen (p24)), Genebank NM_005242 (F2RL1, Coagulation factor II (thrombin) receptor-like 1), Gene Registration Number (Genebank) AK095781 (CIRBP, Cold inducible RNA binding protein), Gene Registration Number (Genebank) X14789 (CRYAA, Crystallin, alpha A), Gene Registration Number (Genebank) Y11307 (CYR61, Cysteine-rich, angiogenic inducer, 61), genebank NM_080927 (DCBLD2, Discoidin, CUB and LCCL domain containing 2), genebank AY253982 (GPR54, G protein-coupled receptor 54), genebank (Genebank) AF073799 (GALR3, Galanin receptor 3), gene registration number (Genebank) BI767815 (GP9, Glycoprotein IX (platelet)), gene registration number (Genebank) NM_007353 (GNA12, Guanine nucleotide binding protein (G protein) alpha 12), gene registration Genebank CR623806 (HSPA6, Heat shock 70kDa protein 6 (HSP70B ')), gene registration number ( Genebank) NM_006597 (HSPA8, Heat shock 70kDa protein 8), Genebank AK000252 (FLJ20245, Hypothetical protein FLJ20245), Genebank AK057577 (IRF3, Interferon regulatory factor 3), Genebank (Genebank) L76191 (IRAK1, Interleukin-1 receptor-associated kinase 1), Genebank BC053882 (MT1X, Metallothionein 1X), Genebank AK124709 (NDRG1, N-myc downstream regulated gene 1), Gene accession number (Genebank) NM_002658 (PLAU, Plasminogen activator, urokinase), Genebank (Genebank) U02389 (PRSS15, Protease, serine, 15), Gene accession number (Genebank) NM_005053 (RAD23A, RAD23 homolog A (S. cerevisiae)), Genebank CD357517 (Unknown, Similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U)), Genebank NM_032038 (SPINL, Spinster), Gene Registry Number ( Genebank) H18681 (C20orf139, Sulfiredoxin 1 homolog (S. cerevisiae)), Gene Registration Number (Genebank) BX648190 (WDR1, WD repeat domain 1), Gene Registration Number (Genebank) AK074035 (XAB2, XPA binding protein 2), Gene Registration Number (Genebank) NM_004364 (CEBPA, CCAAT / enhancer binding protein (C / EBP), alpha), Gene Registration Number (Genebank) NM_017572 (MKNK2, MAP kinase interacting serine / threonine kinase 2), Gene Registration Number (Genebank) Z25424 ( MKNK2, MAP kinase interacting serine / threonine kinase 2), gene accession number (Genebank) AB209586 (MAPK13, Mitogen-activated protein kinase 13), gene accession number (Genebank) NM_030662 (MAP2K2, Mitogen-activated protein kinase kinase 2), gene Registration Number (Genebank) AB208849 (SHC1, SHC (Src homology 2 doma) in containing) transforming protein 1), Genebank NM_138473 (SP1, Sp1 transcription factor), Genebank (Genebank) X02812 (TGFB1, Transforming growth factor, beta 1 (Camurati-Engelmann disease)), Gene accession number (Genebank) NM_002880 (RAF1, V-raf-1 murine leukemia viral oncogene homolog 1), gene registration number (Genebank) NM_152221 (CSNK1E, Casein kinase 1, epsilon), gene registration number (Genebank) AB209210 (DVL1, Dishevelled, dsh homolog 1 (Drosophila)), Genebank NM_005438 (FOSL1, FOS-like antigen 1), Genebank AF077820 (LRP5, Low density lipoprotein receptor-related protein 5), Genebank (Genebank) NM_033119 (NKD1, Naked cuticle homolog 1 (Drosophila)), gene registration number (Genebank) AK090488 (PPP2R1A, protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform), gene registration number (Genebank) AL834166 (TCF7, Transcription factor 7 (T-cell specific, HMG-box)), gene registration (Genebank) AY009401 (WNT6, Wingless-type MMTV integration site family, member 6), Gene Registration Number (Genebank) BX649164 (PAI, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), Genebank BM913048 (TIMP1, TIMP metallopeptidase inhibitor 1), Genebank NM_003255 (TIMP2, TIMP metallopeptidase inhibitor 2), Genebank NM_014595 (NT5C, 5 ', 3'-nucleotidase, cytosolic), gene registration number (Genebank) AY461712 (ATP13A2, ATPase type 13A2), gene registration number (Genebank) NM_018590 (GALNACT-2, Chondroitin sulfate GalNAcT-2), gene registration number (Genebank) NM_080757 (C20orf127, Chromosome 20 open reading frame 127), Genebank X16866 (CYP2D7P1, Cytochrome P450, family 2, subfamily D, polypeptide 6), Genebank (Genebank) NM_000782 (CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1) , Gene Registration Number (Genebank) AB002454 (CYP4F3, Cyt ochrome P450, family 4, subfamily F, polypeptide 3), gene accession number (Genebank) AK096809 (CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), gene accession number (Genebank) NM_000786 (CYP51A1, Cytochrome P450, family 51, subfamily A, polypeptide 1), gene accession number (Genebank) NM_017556 (FBLP-1, Filamin binding LIM protein 1), gene accession number (Genebank) AK093560 (INPP1, Inositol polyphosphate-1-phosphatase), gene accession number ( Genebank) NM_005578 (LPP, LIM domain containing preferred translocation partner in lipoma), Gene Registration Number (Genebank) AK222601 (MMP10, Matrix metallopeptidase 10 (stromelysin 2)), Gene Registration Number (Genebank) NM_005947 (MT1B, Metallothionein 1B (functional)) ), Gene Registration Number (Genebank) BC048334 (MT1G, Metallothionein 1G), Gene Registration Number (Genebank) BI488702 (MT1K, Metallothionein 1M), Gene Registration Number (Genebank) NM_182924 (MICAL-L2, MICAL-like 2), Gene Registration Number (Genebank) AK127759 (NDUFS7, NADH dehydrogena se (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase), Genebank NM_203353 (PDLIM7, PDZ and LIM domain 7 (enigma)), Genebank NM_002627 (PFKP, Phosphofructokinase, platelet, Genebank AA862994 (S100A3, S100 calcium binding protein A3), Gene Registration Number (Genebank) NM_003461 (ZYX, Zyxin), Gene Registration Number (Genebank) NM_019112 (ABCA7, ATP-binding cassette, sub-family A (ABC1), member 7), gene bank number (Genebank) AB209054 (ABCB6, ATP-binding cassette, sub-family B (MDR / TAP), member 6), gene bank number (Genebank) U49248 (ABCC2 , ATP-binding cassette, sub-family C (CFTR / MRP), member 2), Genebank NM_020038 (ABCC3, ATP-binding cassette, sub-family C (CFTR / MRP), member 3), gene Genebank BC025358 (ABCD1, ATP-binding cassette, sub-family D (ALD), member 1), Genebank (Genebank) NM_003992 (CLK3, CDC-like kinase 3), Genebank (Kenebank) AK128154 (C9orf86, Chromosome 9 open reading frame 86), Genebank BC006404 (SKD3, ClpB caseinolytic peptidase B homolog (E. coli)), gene accession number (Genebank) BC067254 (COASY, Coenzyme A synthase), gene accession number (Genebank) NM_004398 (DDX10, DEAD (Asp-Glu-Ala-Asp) box polypeptide 10), gene accession number (Genebank) BC038417 (DHX30, DEAH (Asp-Glu-Ala-His) box polypeptide 30), gene accession number (Genebank) NM_138614 (DHX30, DEAH (Asp-Glu-Ala-His) box polypeptide 30), gene accession number (Genebank) NM_032656 (DHX37, DEAH (Asp-Glu-Ala-His) box polypeptide 37), gene accession number (Genebank) NM_020812 (DOCK6, Dedicator of cytokinesis 6), gene accession number (Genebank) NM_004431 (EPHA2, EPH receptor A2), Genebank NM_001961 (EEF2, Eukaryotic translation elongation factor 2), Genebank NM_003751 (EIF3S9, Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa), Genebank AF114818 (SIAHBP1, Fuse-binding protein-interacting repressor, Genebank NM_019096 (GTPBP2, GTP binding protein 2), Gene registration Genebank NM_006572 (GNA13, Guanine nucleotide binding protein (G protein), alpha 13), Gene Registration Number (Genebank) AK128226 (HK1, Hexokinase 1), Gene Registration Number (Genebank) BC069201 (FLJ22761, Hexokinase domain containing 1) , Gene Registration Number (Genebank) NM_006546 (IMP-1, IGF-II mRNA-binding protein 1), Gene Registration Number (Genebank) NM_015155 (KIAA0217, La ribonucleoprotein domain family, member 5), Gene Registration Number (Genebank) NM_018357 ( FLJ11196, La ribonucleoprotein domain family, member 6), Genebank AK127089 (MTHFD1L, Methylenetetrahydrofolate dehydrogenase (NADP + dependent) 1-like), Genebank (Genebank) XM_038150 (MAST3, Microtubule associated serine / threonine kinase 3) Gene Registration Number (Genebank) AB058686 (MYO15B, Myosin XVB pseudogene), Gene Registration Number (Genebank) BC027875 (MYO15B, Myosin XVB pseudogene), Gene Registration Number (Genebank) K122664 (NRBP, Nuclear receptor binding protein), Gene Registration Number (Genebank) NM_001001852 (PIM3, Pim-3 oncogene), Genebank BC094766 (PKN1, Protein kinase N1), Genebank AK094474 (RHOC, Ras homolog gene family, member C), Genebank (Genebank) NM_019034 (RHOF, Ras homolog gene family, member F (in filopodia)), gene accession number (Genebank) NM_016084 (RASD1, RAS, dexamethasone-induced 1), gene accession number (Genebank) AY369207 (RBPMS2, RNA binding protein with multiple splicing 2), Genebank BC069233 (SCYL1, SCY1-like 1 (S. cerevisiae)), Genebank Number AB209553 (STK11, Serine / threonine kinase 11), Genebank Number (Genebank) AK124047 (C20orf119, Similar to embryonic poly (A) binding protein), Genebank Number XM_496374 ( LOC440595, Similar to eukaryotic translation elongation factor 1 alpha 1), Genebank Number (Genebank) NM_005094 (SLC27A4, Solute carrier family 27 (fatty acid transporter), member 4) Genebank Number (Genebank) NM_003330 (TXNRD1, Thioredoxin reductase 1) , Gene Registration Number (Genebank) NM_025195 (TRIB1, Tribbles homolog 1 (Drosophila)), Gene Registration Number (Genebank) BC009900 (UBE1, Ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)), Gene Registration Number (Genebank) AF045458 (ULK1, Unc-51-like kinase 1 (C. elegans)), gene accession number (Genebank) X59303 (VARS2, Valyl-tRNA synthetase), gene accession number (Genebank) AB209808 (AP1M1, Adaptor-related protein complex 1 , mu 1 subunit), gene registration number (Geneban k) AB208804 (AP3D1, Adaptor-related protein complex 3, delta 1 subunit), Gene Registration Number (Genebank) BC000786 (ARFGAP1, ADP-ribosylation factor GTPase activating protein 1), Gene Registration Number (Genebank) AK125277 (APG4B, ATG4 autophagy related 4 homolog B (S. cerevisiae)), Gene Registration Number (Genebank) NM_007097 (CLTB, Clathrin, light polypeptide (Lcb)), Gene Registration Number (Genebank) AK091056 (COBRA1, Cofactor of BRCA1), Gene Registration Number (Genebank) AF349676 (COG3, Component of oligomeric golgi complex 3), gene registration number (Genebank) AB002368 (XPO6, Exportin 6), gene registration number (Genebank) BX648781 (GABARAPL1, GABA (A) receptor-associated protein like 1), gene registration number (Genebank) AK123405 ( GDI1, GDP dissociation inhibitor 1), Genebank NM_004712 (HGS, Hepatocyte growth factor-regulated tyrosine kinase substrate), Genebank AK094897 (IPO4, Importin 4), Genebank L38951 ( KPNB1, Karyopherin (importin) beta 1), Gene Registration Number (Genebank) NM_002268 (KPNA4, Karyopherin alpha 4 (importin alpha 3)), Gene Registration Number (Genebank) AY014403 (KIF13A, Kinesin family member 13A), Gene Registration Number ( Genebank) NM_002867 (RAB3B, RAB3B, member RAS oncogene family), Genebank (Genebank) AK025300 (RANBP3, RAN binding protein 3), Genebank (Genebank) AB014551 (ARHGEF2, Rho / rac guanine nucleotide exchange factor (GEF) 2), Genebank (Genebank) CD049342 (RPL23, Ribosomal protein L23), Genebank NM_005843 (STAM2, Signal transducing adapter molecule (SH3 domain and ITAM motif) 2), Genebank NM_006809 (TOMM34, Translocase of outer mitochondrial membrane 34), Gene registry number (Genebank) BC047528 (TOMM40, Translocase of outer
2) 상기 바이오마커 중에서, 나프탈렌의 노출에 의해 발현이 감소하는 바이오마커 유전자는 하기와 같다: 2) Among the biomarkers, biomarker genes whose expression is reduced by the exposure of naphthalene are as follows:
유전자 등록번호(Genebank) AF130077(ALB, Albumin), 유전자 등록번호(Genebank) NM_021631(FKSG2, Apoptosis inhibitor), 유전자 등록번호(Genebank) AF143236(C17orf88, Apoptosis related protein), 유전자 등록번호(Genebank) NM_001621(AHR, Aryl hydrocarbon receptor), 유전자 등록번호(Genebank) AB209123(BIRC1, Baculoviral IAP repeat-containing 1), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) NM_001167(BIRC4, Baculoviral IAP repeat-containing 4), 유전자 등록번호(Genebank) AW872828(BIRC6, Baculoviral IAP repeat-containing 6(apollon)), 유전자 등록번호(Genebank) AU146963(BCL2, B-cell CLL/lymphoma 2), 유전자 등록번호(Genebank) NM_004331(BNIP3L, BCL2/adenovirus E1B 19kDa interacting protein 3-like), 유전자 등록번호(Genebank) NM_001015049(BAG5, BCL2-associated athanogene 5), 유전자 등록번호(Genebank) NM_014739(BCLAF1, BCL2-associated transcription factor 1), 유전자 등록번호(Genebank) L33477(HSPD1, Cadherin 12, type 2(N-cadherin 2)), 유전자 등록번호(Genebank) NM_001904(CTNNB1, Catenin(cadherin-associated protein), beta 1, 88kDa), 유전자 등록번호(Genebank) NM_005894(CD5L, CD5 antigen-like(scavenger receptor cysteine rich family)), 유전자 등록번호(Genebank) AK124173(FLJ42179, CDNA FLJ42179 fis, clone THYMU2030796), 유전자 등록번호(Genebank) AB209095(CDC2L2, Cell division cycle 2-like 2(PITSLRE proteins)), 유전자 등록번호(Genebank) AK128462(CRR9, Cisplatin resistance related protein CRR9p), 유전자 등록번호(Genebank) NM_016424(CROP, Cisplatin resistance-associated overexpressed protein), 유전자 등록번호(Genebank) NM_003478(CUL5, Cullin 5), 유전자 등록번호(Genebank) NM_018947(CYCS, Cytochrome c, somatic), 유전자 등록번호(Genebank) BC048797(DFFB, DNA fragmentation factor, 40kDa, beta polypeptide(caspase-activated DNase)), 유전자 등록번호(Genebank) AB209361(FAS, Fas(TNF receptor superfamily, member 6)), 유전자 등록번호(Genebank) NM_006144(GZMA, Granzyme A(granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)), 유전자 등록번호(Genebank) BC013326(GAS2, Growth arrest-specific 2), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_005338(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) AK026927(MGC5297, Hypothetical protein MGC5297), 유전자 등록번호(Genebank) AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX648731(JMY, Junction-mediating and regulatory protein), 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) NM_000314(PTEN, Phosphatase and tensin homolog(mutated in multiple advanced cancers 1)), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) BX537500(PDCD4, Programmed cell death 4(neoplastic transformation inhibitor)), 유전자 등록번호(Genebank) NM_013374(PDCD6IP, Programmed cell death 6 interacting protein), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) CR621593(PRG2, Proteoglycan 2, bone marrow(natural killer cell activator, eosinophil granule major basic protein)), 유전자 등록번호(Genebank) BC041849(ROCK1, Rho-associated, coiled-coil containing protein kinase 1), 유전자 등록번호(Genebank) NM_000582(SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)), 유전자 등록번호(Genebank) BC039110(SMNDC1, Survival motor neuron domain containing 1), 유전자 등록번호(Genebank) AB209211(TIA1, TIA1 cytotoxic granule-associated RNA binding protein), 유전자 등록번호(Genebank) AF520785(TNFSF15, Tumor necrosis factor(ligand) superfamily, member 15), 유전자 등록번호(Genebank) NM_002546(TNFRSF11B, Tumor necrosis factor receptor superfamily, member 11b(osteoprotegerin)), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) AB209534(TRA1, Tumor rejection antigen(gp96) 1), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) AB096256(UNC5B, Unc-5 homolog B(C. elegans)), 유전자 등록번호(Genebank) AF055634(UNC5C, Unc-5 homolog C(C. elegans)), 유전자 등록번호(Genebank) AK122953(VDAC1, Voltage-dependent anion channel 1), 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) BC016344(ACPP, Acid phosphatase, prostate), 유전자 등록번호(Genebank) BM921310(ANAPC10, Anaphase promoting complex subunit 10), 유전자 등록번호(Genebank) NM_153186(ANKRD15, Ankyrin repeat domain 15), 유전자 등록번호(Genebank) AY367065(ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)), 유전자 등록번호(Genebank) NM_004071(CLK1, CDC-like kinase 1), 유전자 등록번호(Genebank) CR933728(CDC2 Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_044472(CDC42, Cell division cycle 42(GTP binding protein, 25kDa)), 유전자 등록번호(Genebank) NM_004365(CETN3, Centrin, EF-hand protein, 3(CDC31 homolog, yeast)), 유전자 등록번호(Genebank) NM_016343(CENPF, Centromere protein F, 350/400ka(mitosin)), 유전자 등록번호(Genebank) BC050310(C10orf9, Chromosome 10 open reading frame 9), 유전자 등록번호(Genebank) NM_016446(C9orf127, Chromosome 9 open reading frame 127), 유전자 등록번 호(Genebank) AY257469(CIT, Citron(rho-interacting, serine/threonine kinase 21)), 유전자 등록번호(Genebank) NM_001761(CCNF, Cyclin F), 유전자 등록번호(Genebank) NM_004354(CCNG2, Cyclin G2), 유전자 등록번호(Genebank) NM_004064(CDKN1B, Cyclin-dependent kinase inhibitor 1B(p27, Kip1)), 유전자 등록번호(Genebank) NM_007068(DMC1, DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination(yeast)), 유전자 등록번호(Genebank) AK025142(BPA, dystonin), 유전자 등록번호(Genebank) NM_001950(E2F4, E2F transcription factor 4, p107/p130-binding), 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) AJ245671(EGFL6, EGF-like-domain, multiple 6), 유전자 등록번호(Genebank) NM_004450(ERH, Enhancer of rudimentary homolog(Drosophila)), 유전자 등록번호(Genebank) AL832041(ESCO1, Establishment of cohesion 1 homolog 1(S. cerevisiae)), 유전자 등록번호(Genebank) AL832666(ESCO2, Establishment of cohesion 1 homolog 2(S. cerevisiae)), 유전자 등록번호(Genebank) AK126048(FLJ44060, FLJ44060 protein), 유전자 등록번호(Genebank) BI494022(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) NM_014707(HDAC9, Histone deacetylase 9), 유전자 등록번호(Genebank) BC067253(FLJ40432, Hypothetical protein FLJ40432), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) BC040410(MAPRE1, Microtubule-associated protein, RP/EB family, member 1), 유전자 등록번호(Genebank) AB033337(MPHOSPH1, M-phase phosphoprotein 1), 유전자 등록번호(Genebank) L20321(NEK4, NIMA(never in mitosis gene a)-related kinase 4), 유전자 등록번호(Genebank) AJ627032(NIPBL, Nipped-B homolog(Drosophila)), 유전자 등록번호(Genebank) AL575067(NUDC, Nuclear distribution gene C homolog(A. nidulans)), 유전자 등록번호(Genebank) NM_003884(PCAF, P300/CBP-associated factor), 유전자 등록번호(Genebank) AL833922(PAPD5, PAP associated domain containing 5), 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_016205(PDGFC, Platelet derived growth factor C), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa), 유전자 등록번호(Genebank) NM_006259(PRKG2, Protein kinase, cGMP-dependent, type II), 유전자 등록번호(Genebank) NM_002709(PPP1CB, Protein phosphatase 1, catalytic subunit, beta isoform), 유전자 등록번호(Genebank) NM_003463(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BX647606(PTMA, Prothymosin, alpha(gene sequence 28)), 유전자 등록번호(Genebank) BC068483(RINT-1, Rad50-interacting protein 1), 유전자 등록번호(Genebank) NM_006325(RAN, RAN, member RAS oncogene family), 유전자 등록번 호(Genebank) NM_213590(RFP2, Ret finger protein 2), 유전자 등록번호(Genebank) NM_006910(RBBP6, Retinoblastoma binding protein 6), 유전자 등록번호(Genebank) BC060806(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) BX648668(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) AB208875(SEPT10, Septin 10), 유전자 등록번호(Genebank) AB209677(SEPT7, Septin 7), 유전자 등록번호(Genebank) BX649128(SESN3, Sestrin 3), 유전자 등록번호(Genebank) XM_497098(LOC441488, Similar to Transcription factor Dp-1(E2F dimerization partner 1)(DRTF1-polypeptide-1)(DRTF1)), 유전자 등록번호(Genebank) AK131071(SLC31A2, Solute carrier family 31(copper transporters), member 2), 유전자 등록번호(Genebank) NM_006930(SKP1A, S-phase kinase-associated protein 1A(p19A)), 유전자 등록번호(Genebank) NM_006542(SPHAR, S-phase response(cyclin-related)), 유전자 등록번호(Genebank) BX647885(STMN1, Stathmin 1/oncoprotein 18), 유전자 등록번호(Genebank) NM_014574(STRN3, Striatin, calmodulin binding protein 3), 유전자 등록번호(Genebank) NM_003176(SYCP1, Synaptonemal complex protein 1), 유전자 등록번호(Genebank) BM674777(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_007375(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_006701(TXNL4A, Thioredoxin-like 4A), 유전자 등록번호(Genebank) NM_030756(TCF7L2, Transcription factor 7-like 2(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) NM_000368(TSC1, Tuberous sclerosis 1), 유전자 등록번호(Genebank) NM_006826(YWHAQ, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide), 유전자 등록번호(Genebank) NM_001032410(USP16, Ubiquitin specific peptidase 16), 유전자 등록번호(Genebank) AK095164(KRAS2, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_138271(ATRX, Alpha thalassemia/mental retardation syndrome X-linked(RAD54 homolog, S. cerevisiae)), 유전자 등록번호(Genebank) AK025738(ASF1A, ASF1 anti-silencing function 1 homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) AK125915(CRY1, Cryptochrome 1(photolyase-like)), 유전자 등록번호(Genebank) S62138(DDIT3, DNA-damage-inducible transcript 3), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) CR936783(FLJ40869, Hypothetical protein LOC284952), 유전자 등록번호(Genebank) NM_002431(MNAT1, Menage a trois 1(CAK assembly factor)), 유전자 등록번호(Genebank) BC032617(POLI, Polymerase(DNA directed) iota), 유전자 등록번호(Genebank) NM_002690(POLB, Polymerase(DNA directed), beta), 유전자 등록번호(Genebank) AK025631(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) BC038996(PMS2L1, Postmeiotic segregation increased 2-like 1), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) NM_020165(RAD18, RAD18 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) NM_152442(RAD9B, RAD9 homolog B(S. cerevisiae)), 유전자 등록번호(Genebank) NM_018151(RIF1, RAP1 interacting factor homolog(yeast)), 유전자 등록번호(Genebank) AI281523(SFPQ, Splicing factor proline/glutamine-rich(polypyrimidine tract binding protein associated)), 유전자 등록번호(Genebank) AK057830(TOM1L2, Target of myb1-like 2(chicken)), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) NM_001071(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) AK094617(UBE2V2, Ubiquitin-conjugating enzyme E2 variant 2), 유전자 등록번호(Genebank) NM_003337(UBE2B, Ubiquitin-conjugating enzyme E2B(RAD6 homolog)), 유전자 등록번호(Genebank) CD013992(GSTT2, Glutathione S-transferase theta 2), 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) NM_000847(GSTA3, Glutathione S-transferase A3), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_017460(CYP3A4, Cytochrome P450, family 3, subfamily A, polypeptide 4), 유전자 등록번호(Genebank) BC039065(ADH6, Alcohol dehydrogenase 6(class V)), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) NM_000667(ADH1A, Alcohol dehydrogenase 1A(class I), alpha polypeptide), 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) NM_000690(ALDH2, Aldehyde dehydrogenase 2 family(mitochondrial)), 유전자 등록번호(Genebank) NM_000696(ALDH9A1, Aldehyde dehydrogenase 9 family, member A1), 유전자 등록번호(Genebank) AK093311(ACAA2, Acetyl-Coenzyme A acyltransferase 2(mitochondrial 3-oxoacyl-Coenzyme A thiolase)), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) NM_000016(ACADM, Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain), 유전자 등록번호(Genebank) BC033517(ACOX2, Acyl-Coenzyme A oxidase 2, branched chain), 유전자 등록번호(Genebank) Z28339(AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)), 유전자 등록번호(Genebank) NM_000384(APOB, Apolipoprotein B(including Ag(x) antigen)), 유전자 등록번호(Genebank) AF285167(ABCA1, ATP-binding cassette, sub-family A(ABC1), member 1), 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_003101(SOAT1, Sterol O-acyltransferase(acyl-Coenzyme A: cholesterol acyltransferase) 1), 유전자 등록번호(Genebank) T81314(MBTPS1, Transcribed locus), 유전자 등록번호(Genebank) NM_147156(TMEM23, Transmembrane protein 23), 유전자 등록번호(Genebank) NM_003916(AP1S2, Adaptor-related protein complex 1, sigma 2 subunit), 유전자 등록번호(Genebank) AA298150(AP3S1, Adaptor-related protein complex 3, sigma 1 subunit), 유전자 등록번호(Genebank) AL109702(AP3S2, Adaptor-related protein complex 3, sigma 2 subunit), 유전자 등록번호(Genebank) BU620136(AP4S1, Adaptor-related protein complex 4, sigma 1 subunit), 유전자 등록번호(Genebank) NM_001025595(ARFIP1, ADP-ribosylation factor interacting protein 1(arfaptin 1)), 유전자 등록번호(Genebank) NM_203437(AFTIPHILIN, Aftiphilin protein), 유전자 등록번호(Genebank) NM_006380(APPBP2, Amyloid beta precursor protein(cytoplasmic tail) binding protein 2), 유전자 등록번호(Genebank) BM683433(AP1GBP1, AP1 gamma subunit binding protein 1), 유전자 등록번호(Genebank) AK027773(APG4C, ATG4 autophagy related 4 homolog C(S. cerevisiae)), 유전자 등록번호(Genebank) AF130117(CRBN, Cereblon), 유전자 등록번호(Genebank) NM_001821(CHML, Choroideremia-like(Rab escort protein 2)), 유전자 등록번호(Genebank) AK002165(DKFZP564O123, Chromatin modifying protein 2B), 유전자 등록번호(Genebank) NM_152284(Shax3, Chromatin modifying protein 4C), 유전자 등록번호(Genebank) AW167080(SNF7DC2, Chromatin modifying protein 5), 유전자 등록번호(Genebank) BF790759(SNF7DC2, Chromatin modifying protein 5), 유전자 등록번호(Genebank) NM_018229(C14orf108, Chromosome 14 open reading frame 108), 유전자 등록번호(Genebank) AF130062(CLTC, Clathrin, heavy polypeptide(Hc)), 유전자 등록번호(Genebank) AF273058(CTAGE1, Cutaneous T-cell lymphoma-associated antigen 1), 유전자 등록번호(Genebank) AK023846(DER1, Der1-like domain family, member 1), 유전자 등록번호(Genebank) NM_145261(TIM14, DnaJ(Hsp40) homolog, subfamily C, member 19), 유전자 등록번호(Genebank) AF447177(GNG10, DnaJ-like protein), 유전자 등록번호(Genebank) NM_004125(GNG10, DnaJ-like protein), 유전자 등록번호(Genebank) NM_015171(XPO6, Exportin 6), 유전자 등록번호(Genebank) CA306634(GTF2H3, General transcription factor IIH, polypeptide 3, 34kDa), 유전자 등록번호(Genebank) M57609(GLI3, GLI-Kruppel family member GLI3(Greig cephalopolysyndactyly syndrome)), 유전자 등록번호(Genebank) BC047660(FLJ25422, Hypothetical protein FLJ25422), 유전자 등록번호(Genebank) BC035090(KPNA3, Karyopherin alpha 3(importin alpha 4)), 유전자 등록번호(Genebank) AK093917(KDELR2, KDEL(Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2), 유전자 등록번호(Genebank) NM_173827(FLJ38991, Mitochondrial COX18), 유전자 등록번호(Genebank) NM_018698(NXT2, Nuclear transport factor 2-like export factor 2), 유전자 등록번호(Genebank) BC039468(NUP50, Nucleoporin 50kDa), 유전자 등록번호(Genebank) BC032755(PEX13, Peroxisome biogenesis factor 13), 유전자 등록번호(Genebank) AK023223(RAB10, RAB10, member RAS oncogene family), 유전자 등록번호(Genebank) AL162081(RAB14, RAB14, member RAS oncogene family), 유전자 등록번호(Genebank) AB209698(RAB18, RAB18, member RAS oncogene family), 유전자 등록번호(Genebank) NM_031296(RAB33B, RAB33B, member RAS oncogene family), 유전자 등록번호(Genebank) BC014553(RAB3IP, RAB3A interacting protein(rabin3)), 유전자 등록번호(Genebank) NM_198490(RAB43, RAB43, member RAS oncogene family), 유전자 등록번호(Genebank) NM_004162(RAB5A, RAB5A, member RAS oncogene family), 유전자 등록번호(Genebank) AL136727(RAB6C, RAB6C, member RAS oncogene family), 유전자 등록번호(Genebank) NM_016530(RAB8B, RAB8B, member RAS oncogene family), 유전자 등록번호(Genebank) NM_006267(RANBP2, RAN binding protein 2), 유전자 등록번호(Genebank) NM_020150(SARA1, SAR1 gene homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) AA418814(SEC22L1, SEC22 vesicle trafficking protein-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) AA484677(SEC22L1, SEC22 vesicle trafficking protein-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) NM_031216(SEH1L, SEH1-like(S. cerevisiae)), 유전자 등록번호(Genebank) BC064351(SRP9, Signal recognition particle 9kDa), 유전자 등록번호(Genebank) NM_005843(STAM2, Signal transducing adaptor molecule(SH3 domain and ITAM motif) 2), 유전자 등록번호(Genebank) BX648363(SNX10, Sorting nexin 10), 유전자 등록번호(Genebank) AB209439(SNX15, Sorting nexin 15), 유전자 등록번호(Genebank) NM_014758(SNX19, Sorting nexin 19), 유전자 등록번호(Genebank) NM_021249(SNX6, Sorting nexin 6), 유전자 등록번호(Genebank) NM_004782(SNAP29, Synaptosomal-associated protein, 29kDa), 유전자 등록번호(Genebank) AJ420529(STX7, Syntaxin 7), 유전자 등록번호(Genebank) BC028028(STXBP3, Syntaxin binding protein 3), 유전자 등록번호(Genebank) NM_007269(STXBP3, Syntaxin binding protein 3), 유전자 등록번호(Genebank) NM_003262(TLOC1, Translocation protein 1), 유전자 등록번호(Genebank) AK094603(FLJ37284, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590.), 유전자 등록번호(Genebank) AL832866(VPS29, Vacuolar protein sorting 29(yeast)), 유전자 등록번호(Genebank) AK092532(FLJ10979, Vacuolar protein sorting 53(yeast)), 유전자 등록번호(Genebank) NM_015336(ZDHHC17, Zinc finger, DHHC-type containing 17), 유전자 등록번호(Genebank) AB002303(ZFYVE16, Zinc finger, FYVE domain containing 16), 유전자 등록번호(Genebank) NM_007236(CHP, Calcium binding protein P22), 유전자 등록번호(Genebank) AL137653(BARS, C-terminal binding protein 1), 유전자 등록번호(Genebank) AB017363(FZD1, Frizzled homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_017412(FZD3, Frizzled homolog 3(Drosophila)), 유전자 등록번호(Genebank) AB032417(FZD4, Frizzled homolog 4(Drosophila)), 유전자 등록번호(Genebank) AK125150(MAPK8, Mitogen-activated protein kinase 8), 유전자 등록번호(Genebank) AK025758(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_000933(PLCB4, Phospholipase C, beta 4), 유전자 등록번호(Genebank) AK131561(PRKACA, Protein kinase, cAMP-dependent, catalytic, alpha), 유전자 등 록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) BC078170(WNT2, Wingless-type MMTV integration site family member 2), 유전자 등록번호(Genebank) NM_003392(WNT5A, Wingless-type MMTV integration site family, member 5A), 유전자 등록번호(Genebank) AY009401(WNT6, Wingless-type MMTV integration site family, member 6), 유전자 등록번호(Genebank) AL832664(ANP32E, Acidic(leucine-rich) nuclear phosphoprotein 32 family, member E), 유전자 등록번호(Genebank) NM_138448(ACYP2, Acylphosphatase 2, muscle type), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) NM_175873(LOC134548, Ankyrin repeat domain 43), 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) AB013380(ABCB10, ATP-binding cassette, sub-family B(MDR/TAP), member 10), 유전자 등록번호(Genebank) M75106(CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)), 유전자 등록번호(Genebank) AK131472(FLJ16640, CDNA FLJ16640 fis, clone TESTI4028938, moderately similar to Zinc finger protein 85), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) BC004543(C15orf23, Chromosome 15 open reading frame 23), 유전자 등록번호(Genebank) NM_001012507(C6orf173, Chromosome 6 open reading frame 173), 유전자 등록번호(Genebank) AK000972(C9orf40, Chromosome 9 open reading frame 40), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_018204(CKAP2, Cytoskeleton associated protein 2), 유전자 등록번호(Genebank) NM_006716(ASK, DBF4 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BC045541(LOC200895, Dihydrofolate reductase-like 1), 유전자 등록번호(Genebank) NM_152721(DOK6, Docking protein 6), 유전자 등록번호(Genebank) NM_017645(FAM29A, Family with sequence similarity 29, member A), 유전자 등록번호(Genebank) NM_207418(MGC57827, Family with sequence similarity 72, member A), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) NM_005141(FGB, Fibrinogen beta chain), 유전자 등록번호(Genebank) AB208919(FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)), 유전자 등록번호(Genebank) NM_032117(GAJ, GAJ protein), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) AB007893(KIAA0433, Histidine acid phosphatase domain containing 1), 유전자 등록번호(Genebank) AF032862(HMMR, Hyaluronan-mediated motility receptor(RHAMM)), 유전자 등록번호(Genebank) AK123495(Q5XI42, Hypothetical gene supported by AL713796), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) AL832022(FLJ13910, Hypothetical protein FLJ13910), 유전자 등록번호(Genebank) AL832208(FLJ32312, Hypothetical protein FLJ32312), 유전자 등록번호(Genebank) AB037805(KLHL14, Kelch-like 14(Drosophila)), 유전자 등록번호(Genebank) NM_014736(KIAA0101, KIAA0101), 유전자 등록번호(Genebank) AB046861(KIAA1641, KIAA1641), 유전자 등록번호(Genebank) BC033021(LOC152831, Klotho beta), 유전자 등록번호(Genebank) NM_182551(LYCAT, Lysocardiolipin acyltransferase), 유전자 등록번호(Genebank) NM_002381(MATN3, Matrilin 3), 유전자 등록번호(Genebank) AB018342(MYO10, Myosin X), 유전자 등록번호(Genebank) BX537509(NET1, Neuroepithelial cell transforming gene 1), 유전자 등록번호(Genebank) BX537360(CPSF5, Nudix(nucleoside diphosphate linked moiety X)-type motif 21), 유전자 등록번호(Genebank) NM_033222(PSIP1, PC4 and SFRS1 interacting protein 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_176869(PPA2, Pyrophosphatase(inorganic) 2), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_004586(RPS6KA3, Ribosomal protein S6 kinase, 90kDa, polypeptide 3), 유전자 등록번호(Genebank) BC064610(SEPHS1, Selenophosphate synthetase 1), 유전자 등록번호(Genebank) AK075271(SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)), 유전자 등록번호(Genebank) XM_496355(LOC440577, Similar to nucleophosmin 1), 유전자 등록번호(Genebank) XM_371758(LOC389308, Similar to ribosomal protein L10a), 유전자 등록번호(Genebank) XM_371470(LOC388907, Similar to ribosomal protein L5; 60S ribosomal protein L5), 유전자 등록번호(Genebank) XM_495961(LOC440145, Similar to RIKEN cDNA 2410129H14), 유전자 등록번호(Genebank) XM_496301(LOC440517, Similar to zinc finger protein 91(HPF7, HTF10)), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) NM_180991(SLCO4C1, Solute carrier organic anion transporter family, member 4C1), 유전자 등록번호(Genebank) BC022255(Spc25, Spindle pole body component 25 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BM458612(THRAP6, Thyroid hormone receptor associated protein 6), 유전자 등록번호(Genebank) AI300182(PROS1, Transcribed locus, weakly similar to NP_000304.1 protein S(alpha)), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AY358727(FLJ21934, UDP glucuronosyltransferase 2 family, polypeptide A3), 유전자 등록번호(Genebank) BC035579(ZNF100, Zinc finger protein 100), 유전자 등록번호(Genebank) AB209664(ZNF195, Zinc finger protein 195), 유전자 등록번호(Genebank) AY269786(ZNF429, Zinc finger protein 429), 유전자 등록번호(Genebank) NM_003423(ZNF43, Zinc finger protein 43(HTF6)), 유전자 등록번호(Genebank) NM_016220(ZNF588, Zinc finger protein 588), 유전자 등록번호(Genebank) AK122869(LOC148213, Zinc finger protein 681), 유전자 등록번호(Genebank) AK131527(ZNF15L1, Zinc finger protein 708(KOX8)), 유전자 등록번호(Genebank) NM_003430(ZNF91, Zinc finger protein 91(HPF7, HTF10)), 유전자 등록번 호(Genebank) NM_152626(ZNF92, Zinc finger protein 92(HTF12)).Genebank Number (Genebank) AF130077 (ALB, Albumin), Genebank Number (Genebank) NM_021631 (FKSG2, Apoptosis inhibitor), Genebank Number AF143236 (C17orf88, Apoptosis related protein), Genebank Number NM_001621 ( AHR, Aryl hydrocarbon receptor, Genebank AB209123 (BIRC1, Baculoviral IAP repeat-containing 1), Gene Registration Number (Genebank) NM_001165 (BIRC3, Baculoviral IAP repeat-containing 3), Gene Registration Number (Genebank) NM_001167 (BIRC4, Baculoviral IAP repeat-containing 4), Gene Registration Number (Genebank) AW872828 (BIRC6, Baculoviral IAP repeat-containing 6 (apollon)), Gene Registration Number (Genebank) AU146963 (BCL2, B-cell CLL / lymphoma 2) , Genebank NM_004331 (BNIP3L, BCL2 / adenovirus E1B 19kDa interacting protein 3-like), Genebank NM_001015049 (BAG5, BCL2-associated athanogene 5), Genebank NM_014739 (BCLAF1, BCL2-associated transcription factor 1), present Genebank L33477 (HSPD1, Cadherin 12, type 2 (N-cadherin 2)), Gene Registration Number (Genebank) NM_001904 (CTNNB1, Catenin (cadherin-associated protein), beta 1, 88kDa), Gene Registration Number (Genebank) NM_005894 (CD5L, CD5 antigen-like (scavenger receptor cysteine rich family)), gene accession number (Genebank) AK124173 (FLJ42179, CDNA FLJ42179 fis, clone THYMU2030796), gene accession number (Genebank) AB209095 (CDC2L2, Cell division cycle 2-like 2 (PITSLRE proteins)), Genebank AK128462 (CRR9, Cisplatin resistance related protein CRR9p), Genebank NM_016424 (CROP, Cisplatin resistance-associated overexpressed protein), Gene registry number ( Genebank) NM_003478 (CUL5, Cullin 5), Genebank NM_018947 (CYCS, Cytochrome c, somatic), Genebank (Genebank) BC048797 (DFFB, DNA fragmentation factor, 40 kDa, Beta polypeptide (caspase-activated DNase) Gene accession number (Genebank) AB209361 (FAS, Fas (TNF rec) eptor superfamily, member 6)), Genebank NM_006144 (GZMA, Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)), Genebank BC013326 (GAS2, Growth arrest-specific 2), Gene Registration Number (Genebank) AK122825 (HMGB1, High-mobility group box 1), Gene Registration Number (Genebank) NM_005338 (HIP1, Huntingtin interacting protein 1), Gene Registration Number (Genebank) AK026927 (MGC5297, Hypothetical protein MGC5297) ), Genebank AB208909 (ITGB2, Integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1); macrophage antigen 1 (mac-1) beta subunit)), Genebank AF208043 (IFI16, Interferon, gamma-inducible protein 16), Genebank BX648731 (JMY, Junction-mediating and regulatory protein), Genebank AK122614 (PPARD, Peroxisome proliferative activated receptor, delta), Genebank NM_000314 (PTEN, Phosphatase and tensin homolog (mutated in multiple advanced cancers 1)), Genebank BC047362 ( PHLDA1, Pleckstrin homology-like domain, family A, member 1), Genebank BX537500 (PDCD4, Programmed cell death 4 (neoplastic transformation inhibitor)), Gene Registry (Genebank) NM_013374 (PDCD6IP, Programmed cell death 6 interacting protein), Genebank NM_005400 (PRKCE, Protein Kinase C, epsilon), Genebank (Genebank) CR621593 (PRG2, Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)), gene Genebank BC041849 (ROCK1, Rho-associated, coiled-coil containing protein kinase 1), Gene accession number (Genebank) NM_000582 (SPP1, Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)) , Gene Registration Number (Genebank) BC039110 (SMNDC1, Survival motor neuron domain containing 1), Gene Registration Number (Genebank) AB209211 (TIA1, TIA1 cytotoxic granule-associated RNA binding protein), Gene Registration Number (Genebank) AF520785 (TNFSF15, Tumor necrosis factor (ligand) superfamily, member 15), Genebank NM_002546 (TNFRSF11B, Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin), Genebank NM_148957 (TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), Genebank NM_006290 (TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), Genebank AK125880 (TP53INP1, Tumor protein p53 inducible nuclear protein 1), genes, etc. Number (Genebank) AB209534 (TRA1, Tumor rejection antigen (gp96) 1), Gene Registration Number (Genebank) NM_012479 (YWHAG, Tyrosine 3-monooxygenase / tryptophan 5-monooxygenase activation protein, gamma polypeptide), Gene Registration Number (Genebank) AB096256 (UNC5B, Unc-5 homolog B (C. elegans)), Genebank AF055634 (UNC5C, Unc-5 homolog C (C. elegans)), Genebank AK122953 (VDAC1, Voltage-dependent anion channel 1), Genebank (Genebank) NM_019001 (XRN1, 5'-3 'exoribonuclease 1), Gene Accession Number (Genebank) BC016344 (ACPP, Acid phosphatase, prostate), Gene Accession Number (Genebank) BM921310 (ANAPC10, Anaphase promoting complex subunit 10), Gene Registration Number ( Genebank) NM_153186 (ANKRD15, Ankyrin repeat domain 15), Genebank AY367065 (ASPM, Asp (abnormal spindle) -like, microcephaly associated (Drosophila)), Genebank NM_004071 (CLK1, CDC-like kinase 1), Genebank CR933728 (CDC2 Cell division cycle 2, G1 to S and G2 to M), Genebank NM_044472 (CDC42, Cell division cycle 42 (GTP binding protein, 25kDa)), Genebank (Genebank) NM_004365 (CETN3, Centrin, EF-hand protein, 3 (CDC31 homolog, yeast)), Gene Registration Number ( Genebank) NM_016343 (CENPF, Centromere protein F, 350 / 400ka (mitosin)), Gene Registration Number (Genebank) BC050310 (C10orf9, Chromosome 10 open reading frame 9), Gene Registration Number (Genebank) NM_016446 (C9orf127, Chromosome 9 open reading) frame 127), Genebank AY257469 (CIT, Citron (rho-interacting, serine / threonine kinase 21)), Genebank NM_001761 (CCNF, Cyclin F), Genebank NM_004354 (CCNG2, Cyclin G2), Gene Registration Number (Genebank) NM_004064 (CDKN1B, Cyclin-dependent kinase inhibitor 1B (p27, Kip1)), Gene Registration Number (Genebank) NM_007068 (DMC1, DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast), gene registration number (Genebank) AK025142 (BPA, dystonin), gene registration number (Genebank) NM_001950 (E2F4, E2F transcription factor 4, p107 / p130-binding), gene registration number (Genebank) NM_019063 ( EML4, Echinoderm microtubule associated protein like 4), gene accession number (Genebank ) AJ245671 (EGFL6, EGF-like-domain, multiple 6), Genebank NG_004450 (ERH, Enhancer of rudimentary homolog (Drosophila)), Genebank AL832041 (ESCO1, Establishment of cohesion 1 homolog 1 (S. cerevisiae)), Genebank AL832666 (ESCO2, Establishment of cohesion 1 homolog 2 (S. cerevisiae)), Genebank AK126048 (FLJ44060, FLJ44060 protein), Genebank BI494022 (GRLF1 , Glucocorticoid receptor DNA binding factor 1), gene registration number (Genebank) NM_000189 (HK2, Hexokinase 2), gene registration number (Genebank) NM_014707 (HDAC9, Histone deacetylase 9), gene registration number (Genebank) BC067253 (FLJ40432, Hypothetical protein FLJ40432), Gene Registration Number (Genebank) AL834276 (MGC3207, Hypothetical protein MGC3207), Gene Registration Number (Genebank) NM_006101 (KNTC2, Kinetochore associated 2), Gene Registration Number (Genebank) NM_014751 (MTSS1, Metastasis suppressor 1), Gene Registration Genebank BC040410 (MAPRE1, Microtubule-associated protein, RP / EB family, member 1), Genebank AB033337 (MPHOSPH1, M-phase phosphoprotein 1), Genebank L20321 (NEK4, NIMA (never in mitosis gene a) -related kinase 4), Genebank AJ627032 (NIPBL, Nipped-B homolog (Drosophila)), Genebank AL575067 (NUDC, Nuclear distribution gene C homolog (A. nidulans)), gene Genebank NM_003884 (PCAF, P300 / CBP-associated factor), Genebank AL833922 (PAPD5, PAP associated domain containing 5), Genebank NM_018492 (PBK, PDZ binding kinase), Gene Genebank NM_016205 (PDGFC, Platelet derived growth factor C), Genebank (Genebank) NM_000430 (PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa), Genebank (Menebank) NM_006259 (PRKG2, Protein kinase, cGMP-dependent, type II), Gene Registration Number (Genebank) NM_002709 (PPP1CB, Protein phosphatase 1, catalytic subunit, beta isoform), Gene Registration Number (Genebank) NM_003463 (PTP4A1, Protein tyrosine phosphatase type IVA, member 1 ), Genebank BG647606 (PTMA, Prothymosin, alpha (gene sequence 28)), Genebank BC068483 (RINT-1, Rad50-interacting protein 1), Genebank NM_006325 (RAN, RAN, member RAS oncogene family), Gene Registration Number Genebank NM_213590 (RFP2, Ret finger protein 2), Genebank NM_006910 (RBBP6, Retinoblastoma binding protein 6), Genebank BC060806 (RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), Genebank BX648668 (RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), Genebank AB208875 (SEPT10, Septin 10), Genebank AB209677 (SEPT7, Septin 7), Genebank BX649128 (SESN3, Sestrin 3), Genebank XM_497098 (LOC441488, Similar to Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1-polypeptide-1) (DRTF1 Genetic Accession Number (Genebank) AK131071 (SLC31A2, Solute carrier family 31 (copper transpor) ters), member 2), Genebank NM_006930 (SKP1A, S-phase kinase-associated protein 1A (p19A)), Genebank NM_006542 (SPHAR, S-phase response (cyclin-related)) , Gene Registration Number (Genebank) BX647885 (STMN1, Stathmin 1 / oncoprotein 18), Gene Registration Number (Genebank) NM_014574 (STRN3, Striatin, calmodulin binding protein 3), Gene Registration Number (Genebank) NM_003176 (SYCP1, Synaptonemal complex protein 1 ), Gene Registration Number (Genebank) BM674777 (TARDBP, TAR DNA binding protein), Gene Registration Number (Genebank) NM_007375 (TARDBP, TAR DNA binding protein), Gene Registration Number (Genebank) NM_006701 (TXNL4A, Thioredoxin-like 4A), Genebank NM_030756 (TCF7L2, Transcription factor 7-like 2 (T-cell specific, HMG-box)), Genebank NM_003318 (TTK, TTK protein kinase), Genebank NM_000368 (TSC1, Tuberous sclerosis 1), Gene Registration Number (Genebank) NM_006826 (YWHAQ, Tyrosine 3-monooxygenase / tryptophan 5-monooxygenase activation protein, theta polypeptide), Genebank NM_001032410 (USP16, Ubiquitin specific peptidase 16), Genebank AK095164 (KRAS2, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) Genebank NM_138271 (ATRX, Alpha thalassemia / mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)), Genebank AK025738 (ASF1A, ASF1 anti-silencing function 1 homolog A (S . cerevisiae)), Genebank AK074377 (UHRF1, Chromosome 19 open reading frame 31), Genebank (Genebank) AK125915 (CRY1, Cryptochrome 1 (photolyase-like)), Genebank S62138 (DDIT3 , DNA-damage-inducible transcript 3), gene registration number (Genebank) DQ140356 (KIAA1596, Fanconi anemia, complementation group M), gene registration number (Genebank) CR600021 (HMGB2, High-mobility group box 2), gene registration number ( Genebank) CR936783 (FLJ40869, Hypothetical protein LOC284952), Genebank NM_002431 (MNAT1, Menage a trois 1 (CAK assembly factor)), Genebank BC032617 (POLI, Polymerase (DNA directed) iota), Genebank (Genebank) NM_002690 (POLB, Polymerase (DNA directed), beta), Gene Registration Number (Genebank) AK025631 (POLH, Polymerase (DNA directed), eta), Gene Registration Number (Genebank) BC038996 (PMS2L1, Postmeiotic segregation increased 2-like 1), Genebank BM462208 (PCNA, Pr oliferating cell nuclear antigen, Genebank NM_020165 (RAD18, RAD18 homolog (S. cerevisiae)), Gene Registry Number (Genebank) NM_152442 (RAD9B, RAD9 homolog B (S. cerevisiae)), Gene Registry Number (Genebank) ) NM_018151 (RIF1, RAP1 interacting factor homolog (yeast)), Genebank AI281523 (SFPQ, Splicing factor proline / glutamine-rich (polypyrimidine tract binding protein associated)), Gene accession number (Genebank) AK057830 (TOM1L2, Target of myb1-like 2 (chicken)), Genebank NM_001012716 (TYMS, Thymidylate synthetase), Genebank NM_001071 (TYMS, Thymidylate synthetase), Genebank NM_003368 (USP1, Ubiquitin) specific peptidase 1), gene registration number (Genebank) AK094617 (UBE2V2, Ubiquitin-conjugating enzyme E2 variant 2), gene registration number (Genebank) NM_003337 (UBE2B, Ubiquitin-conjugating enzyme E2B (RAD6 homolog)), gene registration number (Genebank) ) CD013992 (GSTT2, Glutathione S-tr ansferase theta 2), Gene Registration Number (Genebank) J05428 (UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), Gene Registration Number (Genebank) NM_000847 (GSTA3, Glutathione S-transferase A3), Gene Registration Number (Genebank) M15943 (ADH4) , Alcohol dehydrogenase 4 (class II), pi polypeptide), Gene Registration Number (Genebank) NM_017460 (CYP3A4, Cytochrome P450, family 3, subfamily A, polypeptide 4), Gene Registration Number (Genebank) BC039065 (ADH6, Alcohol dehydrogenase 6 ( class V)), gene registration number (Genebank) NM_000671 (ADH5, Alcohol dehydrogenase 5 (class III), chi polypeptide), gene registration number (Genebank) NM_000667 (ADH1A, Alcohol dehydrogenase 1A (class I), alpha polypeptide), gene Genebank BI762502 (GSTA2, Glutathione S-transferase A2), Gene Registration Number (Genebank) NM_000690 (ALDH2, Aldehyde dehydrogenase 2 family (mitochondrial)), Gene Registration Number (Genebank) NM_000696 (ALDH9A1, Aldehyde dehydrogenase 9 member A1), gene registration number ( Genebank) AK093311 (ACAA2, Acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)), Gene Registration Number (Genebank) NM_004457 (ACSL3, Acyl-CoA synthetase long-chain family member 3), Gene Registration Number ( Genebank) NM_000016 (ACADM, Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain), Gene Registration Number (Genebank) BC033517 (ACOX2, Acyl-Coenzyme A oxidase 2, branched chain), Gene Registration Number (Genebank) Z28339 (AKR1D1, Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)), Genebank NM_000384 (APOB, Apolipoprotein B (including Ag (x) antigen)) , Genebank AF285167 (ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1), Genebank NG_000236 (LIPC, Lipase, hepatic), Genebank AK124635 (PCSK9, Proprotein convertase subtilisin / kexin type 9), Gene Registration Number (Genebank) NM_003101 (SOAT1, Sterol O-acyltransferase (acyl-Coenzyme A: choleste rol acyltransferase) 1), Genebank T81314 (MBTPS1, Transcribed locus), Genebank NM_147156 (TMEM23, Transmembrane protein 23), Genebank NM_003916 (AP1S2, Adaptor-related protein complex 1, sigma 2 subunit), gene registration number (Genebank) AA298150 (AP3S1, Adaptor-related protein complex 3, sigma 1 subunit), gene registration number (Genebank) AL109702 (AP3S2, Adaptor-related protein complex 3, sigma 2 subunit) , Gene Registration Number (Genebank) BU620136 (AP4S1, Adaptor-related protein complex 4, sigma 1 subunit), Gene Registration Number (Genebank) NM_001025595 (ARFIP1, ADP-ribosylation factor interacting protein 1 (arfaptin 1)), Gene Registration Number ( Genebank) NM_203437 (AFTIPHILIN, Aftiphilin protein), Gene Registration Number (Genebank) NM_006380 (APPBP2, Amyloid beta precursor protein (cytoplasmic tail) binding protein 2), Gene Registration Number (Genebank) BM683433 (AP1GBP1, AP1 gamma subunit binding protein 1) , Gene registration number (Genebank) AK027773 (APG4C, ATG4 autophagy related 4 homolog C (S. cerevisiae)), Gene Registration Number (Genebank) AF130117 (CRBN, Cereblon), Gene Registration Number (Genebank) NM_001821 (CHML, Choroideremia-like (Rab escort protein 2)), Gene Registration Number (Genebank) AK002165 (DKFZP564O123, Chromatin modifying protein 2B), gene accession number (Genebank) NM_152284 (Shax3, Chromatin modifying protein 4C), gene accession number (Genebank) AW167080 (SNF7DC2, Chromatin modifying protein 5), gene accession number (Genebank) BF790759 (SNF7DC2, Chromatin modifying protein 5 ), Gene Registration Number (Genebank) NM_018229 (C14orf108, Chromosome 14 open reading frame 108), Gene Registration Number (Genebank) AF130062 (CLTC, Clathrin, heavy polypeptide (Hc)), Gene Registration Number (Genebank) AF273058 (CTAGE1, Cutaneous) T-cell lymphoma-associated antigen 1), Genebank AK023846 (DER1, Der1-like domain family, member 1), Genebank (Genebank) NM_145261 (TIM14, DnaJ (Hsp40) homolog, subfamily C, member 19), Genebank AF447177 ( GNG10, DnaJ-like protein, Genebank NM_004125 (GNG10, DnaJ-like protein), Gene Registration Number (Genebank) NM_015171 (XPO6, Exportin 6), Genebank Number CA306634 (GTF2H3, General transcription factor IIH, polypeptide 3, 34 kDa), Genebank M57609 (GLI3, GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)), Genebank BC047660 (FLJ25422, Hypothetical protein FLJ25422), gene registry number (Genebank) BC035090 (KPNA3, Karyopherin alpha 3 (importin alpha 4)), gene registration number (Genebank) AK093917 (KDELR2, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2), gene registration number (Genebank) ) NM_173827 (FLJ38991, Mitochondrial COX18), Genebank Number (Genebank) NM_018698 (NXT2, Nuclear Transport Factor 2-like export factor 2), Genebank Number BC039468 (NUP50, Nucleoporin 50kDa), Gene Registration Number (Genebank) BC032755 (PEX13, Peroxisome biogenesis facto r 13), Genebank number AK023223 (RAB10, RAB10, member RAS oncogene family), Genebank number AL162081 (RAB14, RAB14, member RAS oncogene family), Genebank number AB209698 (RAB18, RAB18, member RAS oncogene family, Genebank NM_031296 (RAB33B, RAB33B, member RAS oncogene family), Gene Registration Number (Genebank) BC014553 (RAB3IP, RAB3A interacting protein (rabin3)), Gene Registration Number (Genebank) NM_198490 (RAB43, RAB43, member RAS oncogene family), Gene Registration Number (Genebank) NM_004162 (RAB5A, RAB5A, member RAS oncogene family), Gene Registration Number (Genebank) AL136727 (RAB6C, RAB6C, member RAS oncogene family), Gene Registration Genebank NM_016530 (RAB8B, RAB8B, member RAS oncogene family), Genebank NM_006267 (RANBP2, RAN binding protein 2), Genebank NM_020150 (SARA1, SAR1 gene homolog A (S. cerevisiae)), Genebank No. AA418814 (SEC22L1, SEC22 vesicle trafficking protein-like 1 (S. cerevisiae)), Genebank No. AA484677 (SEC22L1, SEC22 vesicle trafficking protein-like 1 (S. cerevisiae) ), Gene Registration Number (Genebank) NM_031216 (SEH1L, SEH1-like (S. cerevisiae)), Gene Registration Number (Genebank) BC064351 (SRP9, Signal recognition particle 9kDa), Gene Registration Number (Genebank) NM_005843 (STAM2, Signal transducing adapter molecule (SH3 domain and ITAM motif) 2), Genebank BX648363 (SNX10, Sorting nexin 10), Genebank AB209439 (SNX15, Sorting nexin 15), Genebank NM_014758 ( SNX19, Sorting nexin 19), Genebank NM_021249 (SNX6, Sorting nexin 6), Genebank NG_004782 (SNAP29, Synaptosomal-associated protein, 29kDa), Genebank AJ420529 (STX7, Syntaxin 7), Genebank BC028028 (STXBP3, Syntaxin bindin g protein 3), Genebank NM_007269 (STXBP3, Syntaxin binding protein 3), Genebank NM_003262 (TLOC1, Translocation protein 1), Genebank AK094603 (FLJ37284, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590.), Gene Registration Number (Genebank) AL832866 (VPS29, Vacuolar protein sorting 29 (yeast)), Gene Registration Number (Genebank) AK092532 (FLJ10979, Vacuolar protein sorting 53 (yeast)), Gene Genebank NM_015336 (ZDHHC17, Zinc finger, DHHC-type containing 17), Gene Registration Number (Genebank) AB002303 (ZFYVE16, Zinc finger, FYVE domain containing 16), Genebank (Menebank) NM_007236 (CHP, Calcium binding protein P22), Genebank AL137653 (BARS, C-terminal binding protein 1), Genebank Number (Genebank) AB017363 (FZD1, Frizzled homolog 1 (Drosophila)), Genebank Number NM_017412 (FZD3, Frizzled homolog 3 (Drosophila)), Gene Registration Number (Genebank) AB032417 (FZD4, Frizzled homolog 4 (Drosophila)), Gene Registration Number (Genebank) AK125150 (MAPK8, Mitogen-activated protein kinase 8), Gene Registration Number (Genebank) AK025758 (NFATC2, Nuclear factor of activated T-cells, cytoplasmic, c alcineurin-dependent 2), gene registration number (Genebank) NM_000933 (PLCB4, Phospholipase C, beta 4), gene registration number (Genebank) AK131561 (PRKACA, Protein kinase, cAMP-dependent, catalytic, alpha), gene registration number ( Genebank) AF026692 (SFRP4, Secreted frizzled-related protein 4), Genebank BC078170 (WNT2, Wingless-type MMTV integration site family member 2), Genebank NM_003392 (WNT5A, Wingless-type MMTV integration site family, member 5A), Genebank AY009401 (WNT6, Wingless-type MMTV integration site family, member 6), Genebank AL832664 (ANP32E, Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E), gene registration number (Genebank) NM_138448 (ACYP2, Acylphosphatase 2, muscle type), gene registration number (Genebank) AK000643 (ASB9, Ankyrin repeat and SOCS box-containing 9), gene registration number (Genebank) NM_175873 (LOC134548 , Ankyrin repeat domain 43), gene registration number (Geneb ank) AF279145 (ANTXR1, Anthrax toxin receptor 1), Gene Banking Number AB013380 (ABCB10, ATP-binding cassette, sub-family B (MDR / TAP), member 10), Gene Banking Number M75106 (CPB2 , Carboxypeptidase B2 (plasma, carboxypeptidase U)), Genebank AK131472 (FLJ16640, CDNA FLJ16640 fis, clone TESTI4028938, moderately similar to Zinc finger protein 85), Genebank (Genebank) NM_001809 (CENPA, Centromere protein A , 17kDa), Genebank AB091343 (C10orf3, Centrosomal protein 55kDa), Genebank (Genebank) BC004543 (C15orf23, Chromosome 15 open reading frame 23), Genebank (Menebank) NM_001012507 (C6orf173, Chromosome 6 open reading frame 173), Genebank AK000972 (C9orf40, Chromosome 9 open reading frame 40), Genebank (Genebank) NM_001801 (CDO1, Cysteine dioxygenase, type I), Genebank (Genebank) NM_018204 (CKAP2, Cytoskeleton associated protein 2), gene Registration number (Genebank) NM_006716 (ASK, DBF4 homolog (S. cerevisiae)), Genebank BC045541 (LOC200895, Dihydrofolate reductase-like 1), Genebank NM_152721 (DOK6, Docking protein 6), Genebank NM_017645 (FAM29A, Family with sequence similarity 29, member A), Genebank NM_207418 (MGC57827, Family with sequence similarity 72, member A), Genebank AK055221 (FBXO5, F-box protein 5), Genebank NM_005141 (FGB, Fibrinogen beta chain), Genebank AB208919 (FGFR1, Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)), Genebank NM_032117 (GAJ, GAJ protein), Genebank (Genebank) NM_020918 (GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), Genebank (Genebank) AB007893 (KIAA0433, Histidine acid phosphatase domain containing 1), Genebank (Genebank) AF032862 (HMMR, Hyaluronan- mediated motility receptor (RHAMM) ), Gene Registration Number (Genebank) AK123495 (Q5XI42, Hypothetical gene supported by AL713796), Gene Registration Number (Genebank) NM_018291 (FLJ10986, Hypothetical protein FLJ10986), Gene Registration Number (Genebank) AL832022 (FLJ13910, Hypothetical protein FLJ13910), Gene Registration Number (Genebank) AL832208 (FLJ32312, Hypothetical protein FLJ32312), Gene Registration Number (Genebank) AB037805 (KLHL14, Kelch-like 14 (Drosophila)), Gene Registration Number (Genebank) NM_014736 (KIAA0101, KIAA0101), Gene Registration Number (Genebank) AB046861 (KIAA1641, KIAA1641), Gene Registration Number (Genebank) BC033021 (LOC152831, Klotho beta), Gene Registration Number (Genebank) NM_182551 (LYCAT, Lysocardiolipin acyltransferase), Gene Registration Number (Genebank) NM_002381 (MATN3, Malin3) ), Gene Registration Number (Genebank) AB018342 (MYO10, Myosin X), Gene Registration Number (Genebank) BX537509 (NET1, Neuroepithelial cell transforming gene 1), Gene Registration Number (Genebank) BX537360 (CPSF5, Nudix (nucleoside diphosphate li) nked moiety X) -type motif 21), Genebank NM_033222 (PSIP1, PC4 and SFRS1 interacting protein 1), Genebank NM_000277 (PAH, Phenylalanine hydroxylase), Genebank NM_176869 ( PPA2, Pyrophosphatase (inorganic) 2), Gene Registration Number (Genebank) NM_013277 (RACGAP1, Rac GTPase activating protein 1), Gene Registration Number (Genebank) NM_004586 (RPS6KA3, Ribosomal protein S6 kinase, 90 kDa, polypeptide 3), Gene Registration Number (Genebank) BC064610 (SEPHS1, Selenophosphate synthetase 1), Gene Registration Number (Genebank) AK075271 (SPTLC2L, Serine palmitoyltransferase, Long chain base subunit 2-like (aminotransferase 2)), Gene Registration Number (Genebank) XM_496355 (LOC440577, Similar to nucleophosmin 1), Genebank XM_371758 (LOC389308, Similar to ribosomal protein L10a), Genebank XM_371470 (LOC388907, Similar to ribosomal protein L5; 60S ribosomal protein L5), gene registration number (Genebank) XM_495961 (LOC440145, Similar to RIKEN cDNA 2410129H14), gene registration number (Genebank) XM_496301 (LOC440517, Similar to zinc finger protein 91 (HPF7, HTF10)), gene registration number ( Genebank) BX640965 (SLC22A3, Solute carrier family 22 (extraneuronal monoamine transporter), member 3), gene accession number (Genebank) NM_180991 (SLCO4C1, Solute carrier organic anion transporter family, member 4C1), gene accession number (Genebank) BC022255 (Spc25) , Spindle pole body component 25 homolog (S. cerevisiae)), Genebank BM458612 (THRAP6, Thyroid hormone receptor associated protein 6), Genebank AI300182 (PROS1, Transcribed locus, weakly similar to NP_000304. 1 protein S (alpha), Genebank AL133031 (MLR1, Transcription factor MLR1), Genebank AY358727 (FLJ21934, UDP glucuronosyltransferase 2 family, polypeptide A3), Genebank BC035 579 (ZNF100, Zinc finger protein 100), Genebank AB209664 (ZNF195, Zinc finger protein 195), Genebank AY269786 (ZNF429, Zinc finger protein 429), Gene Registration Number (Genebank) NM_003423 ( ZNF43, Zinc finger protein 43 (HTF6), Genebank NM_016220 (ZNF588, Zinc finger protein 588), Genebank AK122869 (LOC148213, Zinc finger protein 681), Genebank AK131527 (ZNF15L1, Zinc finger protein 708 (KOX8)), Genebank NM_003430 (ZNF91, Zinc finger protein 91 (HPF7, HTF10)), Genebank NM_152626 (ZNF92, Zinc finger protein 92 (HTF12) )).
본 발명자들은 나프탈렌에 대한 노출 여부 확인용 바이오마커를 발굴하기 위하여, 나프탈렌을 인간 간암 세포주(HepG2)에 처리하여 세포 독성을 확인하였다. 그 결과, 상기 나프탈렌은 인간 간암 세포주에 독성을 가짐이 확인되었고(도 1 참조), 상기 실험을 바탕으로 나프탈렌의 농도를 결정하였다. 이후 상기 결정된 농도로 나프탈렌을 인간 간암 세포주에 처리하고, 상기 물질을 처리한 세포주에서 mRNA를 분리하여 cDNA를 합성하면서 형광물질(Cy5)로 표지하였으며, 약물을 처리하지 않은 대조군의 경우 Cy3로 표지하였다. 상기 형광표지된 cDNA를 44 k 올리고마이크로어레이 칩 Human whole genome microarray(Agilent, USA)와 혼성화하였고, 형광 이미지를 스캔하여 유전자 발현 양상의 차이를 분석하였다(도 2 참조). 분석시 Cy5/Cy3 비율이 2.0배 이상인 경우 발현 증가된 유전자로 분류하였고, 0.5배 이하인 경우 발현 감소된 유전자로 분류하였다. 분석 결과, 발현 증가된 유전자는 0.86%(44,000개의 유전자 중 377개) 발현이 감소된 유전자는 0.71%(44,000개의 유전자 중 313개)임을 확인하였다. 이때, 나프탈렌에 의해 2배 이상 과발현 혹은 저발현 되는 유전자들을 분류한 기능별로 분류하면, 세포 주기(cell cycle), 세포 성장(cell growth), 세포 이동(cell migration), 아팝토시스(apoptosis), 전사(transcription), 뉴클레오티드 결합(nucleotide binding), 금속원소 결합(metal binding), 자극에 대한 반응(Response to stimulus), 징크-핑거(Zinc-finger), 단백질 전달(protein transport), 면역반응(immune response), MAPKinase 신호 경 로(MAPKinase signaling Pathway), WNT 신호 경로(WNT signaling pathway), 지방산 대사(fatty acid metabolism), 지질 대사(lipid metabolism), 사이토크롬에 의한 외부물질의 대사(metabolism of xenobiotics by cytochrome), 알코올 대사(Alcohol metabolism), DNA 손상 반응(response to DNA damage stimulus) 또는 갭 결합(Gap Junction) 등의 관련 유전자들이었다(표 2 및 표 3 참조). 상기 유전자들은 본 발명에서 사용한 나프탈렌을 처리했을 때, 인간 간암 세포에서 독성과 관련이 있다는 보고는 없다.The present inventors treated the naphthalene to human liver cancer cell line (HepG2) to confirm the cytotoxicity in order to find a biomarker for confirming the exposure to naphthalene. As a result, the naphthalene was confirmed to be toxic to human liver cancer cell line (see FIG. 1), and the concentration of naphthalene was determined based on the experiment. Thereafter, naphthalene was treated to the human liver cancer cell line at the determined concentration, mRNA was isolated from the cell line treated with the substance, and cDNA was synthesized and labeled with fluorescent material (Cy5). . The fluorescently labeled cDNA was hybridized with a 44 k oligomicroarray chip, Human whole genome microarray (Agilent, USA), and analyzed for differences in gene expression patterns by scanning fluorescent images (see FIG. 2). In the analysis, when the Cy5 / Cy3 ratio was 2.0 times or more, the expression was increased. As a result, it was confirmed that the gene with increased expression was 0.86% (377 of 44,000 genes) and 0.71% (313 of 44,000 genes) with reduced expression. In this case, when the genes that are overexpressed or low-expressed by naphthalene more than two times are classified by the function classified, cell cycle, cell growth, cell migration, apoptosis, and apoptosis, Transcription, nucleotide binding, metal binding, response to stimulus, zinc-finger, protein transport, immune response response, MAPKinase signaling Pathway, WNT signaling pathway, fatty acid metabolism, lipid metabolism, and cytochrome metabolism of foreign substances (metabolism of xenobiotics by Related genes were cytochrome, alcohol metabolism, response to DNA damage stimulus or gap junction (see Table 2 and Table 3). The genes have not been reported to be associated with toxicity in human liver cancer cells when treated with naphthalene used in the present invention.
본 발명자들은 상기 유전자 중 과발현된 유전자 24종과 저발현된 유전자 21종을 분리하여 실시간 RT-PCR(real-time reverse transcript polymerase chain reaction) 방법으로 발현 양상을 조사하였다. 그 결과, 24종의 과발현 유전자들과 21종의 저발현 유전자의 발현 양상이 올리고마이크로어레이 칩 결과와 유사하게 나타남을 확인하였다(표 5 참조). 이들 유전자들은 유전자 등록번호(Genebank) BM913048(TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) BU945318(metallothionein 2A), 유전자 등록번호(Genebank) BM926478(Retinol binding protein 1, cellular), 유전자 등록번호(Genebank) X02812(Transforming growth factor, beta 1(Camurati-Engelmann disease)), 유전자 등록번호(Genebank) NM_004864(Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_003897(Immediate early response 3), 유전자 등록번호(Genebank) BC042390(Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)), 유전자 등록번호(Genebank) NM_017572(MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) NM_173481(Chromosome 19 open reading frame 21), 유전자 등록번호(Genebank) NM_032468(Aspartate beta-hydroxylase), 유전자 등록번호(Genebank) AY247738(Tribbles homolog 3(Drosophila)), 유전자 등록번호(Genebank) AK095363(Aquaporin 3), 유전자 등록번호(Genebank) AA669162(Adenosine monophosphate deaminase(isoform E)), 유전자 등록번호(Genebank) NM_003516(Histone 2, H2aa), 유전자 등록번호(Genebank) NM_003255(TIMP metallopeptidase inhibitor 2), 유전자 등록번호(Genebank) NM_080388(S100 calcium binding protein A16), 유전자 등록번호(Genebank) BX649164(serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_001013632(polo-like kinase 3(Drosophila)), 유전자 등록번호(Genebank) BQ683841(S100 calcium binding protein A11(calgizzarin)), 유전자 등록번호(Genebank) Y11307(Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) AK094474(Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_001769(CD9 antigen(p24)), 유전자 등록번호(Genebank) BC035124(MSFL2541), 유전자 등록번호(Genebank) NM_000499(Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) AF167706(Cysteine rich transmembrane BMP regulator 1(chordin-like)), 유전자 등록번호(Genebank) AB046861(KIAA1641), 유전자 등록번호(Genebank) BC068588(Similar to CG32820-PA, isoform A), 유전자 등록번호(Genebank) AY358727(UDP glucuronosyltransferase 2 family, polypeptide A3), 유전자 등록번호(Genebank) NM_017768(Leucine rich repeat containing 40), 유전자 등록번호(Genebank) AA074156(Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [Mus musculus]), 유전자 등록번호(Genebank) XM_291202(Zinc finger protein 479), 유전자 등록번호(Genebank) AB013380(ATP-binding cassette, sub-family B(MDR/TAP), member 10), 유전자 등록번호(Genebank) NM_180991(Solute carrier organic anion transporter family, member 4C1), 유전자 등록번호(Genebank) BC022255(Spindle pole body component 25 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) AK074377(Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) BX640965(Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) CR600021(High-mobility group box 2), 유전자 등록번호(Genebank) NM_006101(Kinetochore associated 2), 유전자 등록번호(Genebank) NM_145697(Cell division cycle associated 1), 유전자 등록번호(Genebank) AB091343(Centrosomal protein 55kDa), 유전자 등록번호(Genebank) BX640888(Glypican 6), 유전자 등록번호(Genebank) NM_018492(PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK protein kinase), 유전자 등록번호(Genebank) U65410(MAD2 mitotic arrest deficient-like 1(yeast)), 유전자 등록번호(Genebank) NM_001067(Topoisomerase(DNA) II alpha 170kDa)이다.The present inventors separated 24 overexpressed genes and 21 underexpressed genes and examined expression patterns by real-time reverse transcript polymerase chain reaction (RT-PCR) method. As a result, it was confirmed that the expression patterns of 24 overexpression genes and 21 low expression genes were similar to those of the oligomicroarray chip (see Table 5). These genes are genebank BM913048 (TIMP metallopeptidase inhibitor 1), genebank (Genebank) BU945318 (metallothionein 2A), genebank BM926478 (Retinol binding protein 1, cellular), genebank (Genebank) X02812 (Transforming growth factor, beta 1 (Camurati-Engelmann disease)), Genebank (Genebank) NM_004864 (Growth differentiation factor 15), Genebank (Genebank) NM_003897 (Immediate early response 3), Genebank (Genebank) ) BC042390 (Vesicle transport through interaction with t-SNAREs homolog 1B (yeast), Genebank NM_017572 (MAP kinase interacting serine / threonine kinase 2), Genebank NM_173481 (Chromosome 19 open reading frame 21 ), Gene Registration Number (Genebank) NM_032468 (Aspartate beta-hydroxylase), Gene Registration Number (Genebank) AY247738 (Tribbles homolog 3 (Drosophila)), Gene Registration Number (Genebank) AK095363 (Aquaporin 3), Genetic Genebank AA669162 (Adenosine monophosphate deaminase (isoform E)), Gene Registration Number (Genebank) NM_003516 (Histone 2, H2aa), Gene Registration Number (Genebank) NM_003255 (TIMP metallopeptidase inhibitor 2), Gene Registration Number (Genebank) NM_080388 (S100 calcium binding protein A16), gene registration number (Genebank) BX649164 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), gene registration number (Genebank) NM_001013632 (polo-like kinase 3 (Drosophila), Genebank BQ683841 (S100 calcium binding protein A11 (calgizzarin)), Genebank Number (Genebank) Y11307 (Cysteine-rich, angiogenic inducer, 61), Genebank AK094474 (Ras) homolog gene family, member C), gene registration number (Genebank) NM_001769 (CD9 antigen (p24)), gene registration number (Genebank) BC035124 (MSFL2541), gene registration number (Genebank) NM_000499 (Cytochrome P450, family 1, subfamily A , polypeptide 1), gene registration number ( Genebank) AF167706 (Cysteine rich transmembrane BMP regulator 1 (chordin-like)), Gene Registration Number (Genebank) AB046861 (KIAA1641), Gene Registration Number (Genebank) BC068588 (Similar to CG32820-PA, isoform A), Gene Registration Number ( Genebank) AY358727 (UDP glucuronosyltransferase 2 family, polypeptide A3), gene accession number (Genebank) NM_017768 (Leucine rich repeat containing 40), gene accession number (Genebank) AA074156 (Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [ Mus musculus]), Genebank XM_291202 (Zinc finger protein 479), Genebank AB013380 (ATP-binding cassette, sub-family B (MDR / TAP), member 10), Gene registry number ( Genebank) NM_180991 (Solute carrier organic anion transporter family, member 4C1), Gene accession number (Genebank) BC022255 (Spindle pole body component 25 homolog (S. cerevisiae)), Genebank AK074377 (Chromosome 19 open reading frame 31), Gene Registration Number (Genebank) BX640965 (Solute carrier family 22 (extraneuronal monoamine transporter), member 3), Gene Registration Number (Genebank) CR600021 ( High-mobility group box 2), Genebank NM_006101 (Kinetochore associated 2), Genebank NM_145697 (Cell division cycle associated 1), Genebank AB091343 (Centrosomal protein 55kDa), Gene Registration Number (Genebank) BX640888 (Glypican 6), Gene Registration Number (Genebank) NM_018492 (PDZ binding kinase), Gene Registration Number (Genebank) NM_003318 (TTK protein kinase), Gene Registration Number (Genebank) U65410 (MAD2 mitotic arrest deficient- like 1 (yeast), Genebank NM_001067 (Topoisomerase (DNA) II alpha 170kDa).
또한, 본 발명은 상기 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 그의 상보 가닥 분자가 집적된 나프탈렌에 대한 노출 여부 확인용 DNA 마이크로어레이 칩을 제공한다.In addition, the present invention provides a DNA microarray chip for confirming exposure to naphthalene in which an oligonucleotide or a complementary strand molecule thereof including all or part of the biomarker gene sequence is integrated.
상기 올리고 뉴클레오티드 또는 이의 상보가닥 분자는 상기 바이오마커 유전자의 18 내지 30개의 핵산을 포함하고, 바람직하게는 20 내지 25개의 핵산을 포함한다. The oligonucleotide or complementary strand molecule thereof comprises 18 to 30 nucleic acids of the biomarker gene, preferably 20 to 25 nucleic acids.
본 발명의 나프탈렌 검색용 DNA 마이크로어레이 칩은 당업자에게 알려진 방법으로 제작할 수 있다. 상기 마이크로어레이 칩을 제작하는 방법은 하기와 같다. 상기 탐색된 바이오마커를 탐침 DNA 분자로 이용하여 DNA 칩의 기판 상에 고정화시키기 위해 파이조일렉트릭(piezoelectric) 방식을 이용한 마이크로피펫팅(micropipetting)법 또는 핀(pin) 형태의 스폿터(spotter)를 이용한 방법 등을 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 본 발명의 바람직한 실시예에서는 핀 형태의 스폿터인 마이크로어레이를 이용하였다. 상기 DNA 마이크로어레이 칩의 기판은 아미노-실란(amino-silane), 폴리-L-라이신(poly-L-lysine) 및 알데히드(aldehyde)로 이루어진 군에서 선택되는 하나의 활성기가 코팅된 것이 바람직하나 이에 한정되는 것은 아니다. 또한, 상기 기판은 슬라이드 글래스, 플라스틱, 금속, 실리콘, 나일론 막, 및 니트로셀룰로스 막(nitrocellulose membrane)으로 이루어진 군에서 선택될 수 있으나 이에 제한되는 것은 아니며, 본 발명의 바람직한 실시예에서는 아미노-실란이 코팅된 슬라이드 글래스를 이용하였다. The naphthalene retrieval DNA microarray chip of the present invention can be produced by a method known to those skilled in the art. The method of manufacturing the microarray chip is as follows. In order to immobilize the searched biomarker as a probe DNA molecule on a substrate of a DNA chip, a micropipetting method or a pin-shaped spotter using a piezoelectric method is used. It is preferable to use the method, but the present invention is not limited thereto. In a preferred embodiment of the present invention, a microarray, which is a pin-shaped spotter, is used. The substrate of the DNA microarray chip is preferably coated with one active group selected from the group consisting of amino-silane, poly-L-lysine, and aldehyde. It is not limited. In addition, the substrate may be selected from the group consisting of slide glass, plastic, metal, silicon, nylon membrane, and nitrocellulose membrane, but is not limited thereto, and in the preferred embodiment of the present invention, amino-silane may be used. Coated slide glass was used.
또한, 본 발명은 상기 바이오마커를 이용한 나프탈렌에 대한 노출 여부를 확 인하는 방법을 제공한다.In addition, the present invention provides a method for confirming exposure to naphthalene using the biomarker.
본 발명은 하기와 같은 과정을 포함하는 나프탈렌에 대한 노출 여부를 확인하는 방법을 제공한다: The present invention provides a method for confirming exposure to naphthalene comprising the following steps:
1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;1) separating RNA from test subject-derived human somatic cells and control somatic cells;
2) 단계 1)의 실험군과 대조군의 RNA를 cDNA로 합성하면서 실험군과 대조군을 각기 다른 형광물질을 표지하는 단계;2) synthesizing RNA of the experimental group and the control group of step 1) with cDNA and labeling the fluorescent substance of each of the experimental group and the control group;
3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 DNA 마이크로어레이칩과 혼성화시키는 단계;3) hybridizing cDNA labeled with different fluorescent materials of step 2) with DNA microarray chips;
4) 단계 3)의 반응한 DNA 마이크로어레이 칩을 분석하는 단계; 및 4) analyzing the reacted DNA microarray chip of step 3); And
5) 단계 4)의 분석한 데이터에서 본 발명의 바이오마커의 발현 정도를 대조군과 비교하여 확인하는 단계,5) confirming the expression level of the biomarker of the present invention in the analyzed data of step 4) compared to the control group,
상기 노출 여부를 확인하는 방법에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포를 사용하는 것이 바람직하며, 인간 간암 세포주(HepG2)를 사용하는 것이 더욱 바람직하나 이에 한정되는 것은 아니다.In the method for confirming the exposure, the somatic cells of step 1) is preferably using cells derived from human liver or liver cancer cells and tissues, more preferably using a human liver cancer cell line (HepG2) It is not limited.
상기 노출 여부를 확인하는 방법에 있어서, 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택되어지는 것이 바람직하나 이에 한정되는 것은 아니며, 당업자에게 알려진 형광물질은 모두 사용 가능하다.In the method for confirming the exposure, the fluorescent material of step 2) is Cy3, Cy5, poly L-lysine-fluorescein isothiocyanate (FITC), RITC (rhodamine-B-isothiocyanate) and rhodamine (rhodamine) It is preferable to be selected, but not limited thereto, and any fluorescent material known to those skilled in the art may be used.
상기 노출 여부를 확인하는 방법에 있어서, 단계 4)의 DNA 마이크로어레이 칩은 Whole Human Genome Oligo Microarray(Agilent, USA)등을 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 인간 게놈 중 본 발명에서 상기 공통적으로 과발현 또는 저발현 유전자(표 2 및 포 3 참조)가 탑재된 마이크로어레이 칩이라면 사용 가능하고, 상기 본 발명자가 제작한 DNA 마이크로어레이 칩을 사용하는 것이 가장 바람직하다. 또한, 단계 4)의 분석 방법은 GenePix 4.1 소프트웨어(Axon Instruments, USA)를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 당업자에게 알려진 분석 소프트웨어를 사용하여도 무방하다.In the method for confirming the exposure, the DNA microarray chip of step 4) is preferably using Whole Human Genome Oligo Microarray (Agilent, USA) and the like, but is not limited thereto. As long as it is a microarray chip loaded with over- or low-expression genes (see Tables 2 and 3), it is most preferable to use a DNA microarray chip produced by the present inventors. In addition, the analysis method of step 4) preferably uses GenePix 4.1 software (Axon Instruments, USA), but is not limited thereto, and analysis software known to those skilled in the art may be used.
또한, 본 발명은 하기와 같은 과정을 포함하는 나프탈렌에 대한 노출 여부를 확인하는 방법을 제공한다: In addition, the present invention provides a method for confirming exposure to naphthalene comprising the following steps:
1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;1) separating RNA from test subject-derived human somatic cells and control somatic cells;
2) 단계 1)의 RNA를, 본 발명의 바이오마커 유전자에 상보적이고 바이오마커 유전자를 증폭할 수 있는 프라이머를 사용하여 실시간 RT-PCR(Real-time reverse transcript polymerase chain reaction)을 수행하는 단계; 및2) performing a real-time reverse transcript polymerase chain reaction (RT-PCR) using the RNA of step 1) using a primer complementary to the biomarker gene of the present invention and capable of amplifying the biomarker gene; And
3) 단계 2)의 유전자 산물을 대조군과 비교하여 발현 정도를 확인하는 단계,3) confirming the expression level by comparing the gene product of step 2) with the control,
상기 노출 여부를 확인하는 방법에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포를 사용하는 것이 바람직하며, 인간 간암 세포주(HepG2)를 사용하는 것이 더욱 바람직하나 이에 한정되는 것은 아니다.In the method for confirming the exposure, the somatic cells of step 1) is preferably using cells derived from human liver or liver cancer cells and tissues, more preferably using a human liver cancer cell line (HepG2) It is not limited.
상기 노출 여부를 확인하는 방법에 있어서, 단계 2)의 프라이머는 본 발명에서 탐색된 바이오마커 유전자와 상보적이고, 바이오마커를 증폭할 수 있는 프라이머라면 모두 사용가능하다. 본 발명에서는 서열번호 1 내지 90으로 기재되는 정방향 및 역방향의 프라이머 45쌍을 제시하였으나 이에 한정되는 것은 아니다.In the method of confirming the exposure, the primer of step 2) is complementary to the biomarker gene found in the present invention, and any primer that can amplify the biomarker can be used. In the present invention, 45 pairs of the forward and reverse primers set forth in SEQ ID NOs: 1 to 90 are provided, but the present invention is not limited thereto.
아울러, 본 발명은 나프탈렌에 대한 노출 여부 확인용 키트를 제공한다.In addition, the present invention provides a kit for confirming the exposure to naphthalene.
본 발명은 상기 본 발명에서 제작한 DNA 마이크로어레이 칩을 포함하는 나프탈렌에 대한 노출 여부 확인용 키트를 제공한다. The present invention provides a kit for confirming exposure to naphthalene including the DNA microarray chip prepared in the present invention.
상기 확인용 키트에 추가적으로 인간 간세포를 포함하는 나프탈렌에 대한 노출 여부 확인용 키트를 제공한다. 상기 인간 간세포는 HepG2를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포라면 모두 사용 가능하다. In addition to the identification kit provides a kit for confirming the exposure to naphthalene containing human hepatocytes. The human hepatocyte is preferably HepG2, but is not limited thereto. Any human hepatocyte may be used as long as it is derived from cells and tissues of human liver or liver cancer.
상기 키트에 추가적으로 형광물질을 포함할 수 있으며, 상기 형광물질은 스트렙아비딘-알칼리 탈인화효소 접합물질(strepavidin-like phosphatease conjugate), 화학형광물질(chemiflurorensce) 및 화학발광물질(chemiluminescent)로 이루어진 군으로부터 선택되는 것이 바람직하나 이에 한정되는 것은 아니며, 본 발명의 바람직한 실시예에서는 Cy3와 Cy5를 사용하였다. The kit may further include a fluorescent material, wherein the fluorescent material is selected from the group consisting of a strepavidin-like phosphatease conjugate, a chemiflurorensce and a chemiluminescent material. Preferably, but not limited thereto, Cy3 and Cy5 were used in the preferred embodiment of the present invention.
상기 키트에 추가적으로 반응 시약을 포함시킬 수 있으며, 상기 반응 시약은 혼성화에 사용되는 완충용액, RNA로부터 cDNA를 합성하기 위한 역전사효소, cNTPs 및 rNTP(사전 혼합형 또는 분리 공급형), 형광 염색제의 화학적 유도제와 같은 표 식시약, 세척 완충용액 등으로 구성될 수 있으나 이에 한정된 것은 아니며, 당업자에게 알려진 DNA 마이크로어레이 칩의 혼성화 반응에 필요한 반응 시약은 모두 포함시킬 수 있다.The kit may additionally include a reaction reagent, which is a buffer used for hybridization, reverse transcriptase for synthesizing cDNA from RNA, cNTPs and rNTP (premixed or separated feed), chemical inducer of fluorescent dyes It may be composed of a labeling reagent, such as a washing buffer, but is not limited thereto, and may include all reaction reagents required for hybridization of DNA microarray chips known to those skilled in the art.
상기 키트에 추가적으로 바이오마커 유전자에 상보적이고, 바이오마커 유전자를 증폭할 수 있는 프라이머를 포함시킬 수 있다. 상기 프라이머는 서열번호 1 내지 90으로 기재되는 서열로 구성된 군으로부터 선택되는 2개 이상의 정방향 및 역방향의 프라이머를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 상기 바이오마커 유전자에 상보적이며, 바이오마커 유전자를 증폭할 수 있으며 증폭산물이 100 내지 300bp가 되도록 설계된 정방향 및 역방향 프라이머쌍은 모두 사용 가능하다. The kit may further include a primer complementary to the biomarker gene and capable of amplifying the biomarker gene. The primers are preferably one of two or more forward and reverse primers selected from the group consisting of sequences represented by SEQ ID NOs: 1 to 90, but are not limited thereto. Complementary to the biomarker gene, and biomarker gene It is possible to amplify and both the forward and reverse primer pairs designed so that the amplification product is 100 to 300bp can be used.
이하, 본 발명을 실시예에 의해 상세히 설명한다.Hereinafter, the present invention will be described in detail by way of examples.
단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.
<실시예 1> 세포 배양 및 화학물질 처리Example 1 Cell Culture and Chemical Treatment
<1-1> 세포배양<1-1> Cell Culture
인간 간암 세포주인 HepG2 세포(한국 세포주 은행)를 10% FBS가 첨가된 DMEM 배지(Gibro-BRL, USA)를 이용하여 100 ㎜ 디쉬(dish)에서 80% 정도 자랄 때까지 배 양하였다. 본 발명자들은 기존의 연구와 보고를 통해 다환방향족 탄화수소류의 하나로서 발암성을 가지고 있는 물질인 나프탈렌을 선정하였으며, DMSO에 용해시켰다. 매질(vehicle) 농도는 모든 실험에서 0.1% 이하였다.HepG2 cells (Korea Cell Line Bank), a human liver cancer cell line, were cultured using DMEM medium (Gibro-BRL, USA) to which 10% FBS was added until 80% growth in 100 mm dish. The present inventors selected naphthalene, a substance having carcinogenicity, as one of the polycyclic aromatic hydrocarbons, and dissolved it in DMSO through existing studies and reports. Vehicle concentration was less than 0.1% in all experiments.
<1-2> 세포 독성 실험(<1-2> cytotoxicity test ( MTTMTT assayassay ) 및 화학 물질 처리) And chemical processing
Mossman 등(J. Immunol. Methods, 65, 55-63, 1983)의 방법으로 HepG2 세포주를 이용한 MTT 실험을 수행하였다. 세포는 24-웰 플레이트에 4× 105/웰 세포수로 DMEM 배지(Gibro-BRL, USA)에서 DMSO에 용해된 나프탈렌을 처리하고 48시간 후에 MTT(3-4,5-dimethylthiazol-2,5-diphenyltetra zolium bromide) 5 ㎎/㎖을 혼합하여 튜브에 가하여 37℃에서 3 시간 동안 배양하였다. 이 후 배지를 제거하고 형성된 포르마잔 크리스탈(formazan crystal)을 DMSO 500 ㎕에 용해하였다. 96-웰 플레이트로 옮겨 분주(aliquot)하고 흡광도 540 nm에서 O.D.값을 측정하였다. HepG2 세포주에서 나프탈렌의 세포독성을 살펴본 결과, 20% 생존율을 보이는 농도(IC20)는 1772.23 uM 이었으며(도 1), 상기 농도들로 결정하여 마이크로어레이 실험을 수행하였다. MTT experiment using HepG2 cell line was performed by the method of Mossman et al. ( J. Immunol. Methods , 65, 55-63, 1983). Cells were treated with naphthalene dissolved in DMSO in DMEM medium (Gibro-BRL, USA) with 4 × 10 5 / well cell counts in 24-well plates and 48 hours after MTT (3-4,5-dimethylthiazol-2,5 5 mg / ml of -diphenyltetra zolium bromide) was added to the tube and incubated at 37 ° C. for 3 hours. Thereafter, the medium was removed and the formed formazan crystal was dissolved in 500 µl of DMSO. Transfer to a 96-well plate was aliquoted and the OD value was measured at absorbance 540 nm. As a result of examining the cytotoxicity of naphthalene in the HepG2 cell line, the concentration showing 20% survival (IC 20 ) was 1772.23 uM (FIG. 1), and the microarray experiments were performed by determining the concentrations.
<< 실시예Example 2> 2> 마이크로어레이Microarray 실험 Experiment
<2-1> 표적 <2-1> target RNARNA 의 분리 및 형광 물질 표지Isolation and Labeling of Fluorescent Materials
6 × 106 cell/㎖ 농도로 100 mm 디쉬에 HepG2 세포를 분주한 후, 상기 실시 예 <1-2>에서 결정된 나프탈렌의 농도를 48 시간 동안 처리하였다. 이후, 상기 처리한 세포에서 트리졸(trizol) 시약(Invitrogen life technologies, USA)을 사용하여 제조사의 방법대로 전체 RNA를 분리하고, RNeasy mini kit(Qiagen, USA)를 사용하여 정제하였다. 게놈 DNA는 RNA 정제 동안 RNase-free DNase set(Qiagen, USA)를 사용하여 제거하였다. 각 전체 RNA 시료의 양은 분광광도계로 측정하였고, 농도는 Agilent 2100 Bioanalyzer(Agilent Technologies, USA)와 아가로스 젤 전기영동으로 확인하였다. After dispensing HepG2 cells in a 100 mm dish at a concentration of 6 × 10 6 cells / ml, the concentration of naphthalene determined in Example <1-2> was treated for 48 hours. Thereafter, the whole cells were separated from the treated cells using a trizol reagent (Invitrogen life technologies, USA) according to the manufacturer's method, and purified using the RNeasy mini kit (Qiagen, USA). Genomic DNA was removed using RNase-free DNase set (Qiagen, USA) during RNA purification. The amount of each total RNA sample was measured by spectrophotometer and the concentration was confirmed by Agilent 2100 Bioanalyzer (Agilent Technologies, USA) and agarose gel electrophoresis.
<2-2> 표지된 cDNA 제조 <2-2> Labeled cDNA Preparation
올리고 마이크로어레이 분석을 위하여 상기 실시예 <2-1>에서 수득한 나프탈렌 처리군의 전체 RNA를 사용하여 cDNA를 제조하였다. 상기 수득한 전체 RNA 30 ㎍과 올리고(dT) 프라이머 2 ㎍(1 ㎍/㎕)과 혼합하고 65℃에서 10분간 반응시킨 후 바로 얼음에 넣어 어닐링(annealing)시켰다. 상기 어닐링된 RNA의 역전사(Reverse Transcript) 반응을 위해 표 1과 같이 시약을 혼합하였다. For oligo microarray analysis, cDNA was prepared using the total RNA of the naphthalene treatment group obtained in Example <2-1>. The total RNA obtained above was mixed with 30 μg of oligo (dT) primer and 2 μg (1 μg / μl), reacted at 65 ° C. for 10 minutes, and then annealed in ice. Reagents were mixed as shown in Table 1 for Reverse Transcript reaction of the annealed RNA.
대조군인 HepG2 세포주에서 분리한 전체 RNA는 Cy3-dUTP(녹색)로 표지화하였고, 나프탈렌을 처리한 HepG2 세포주로부터 분리한 RNA는 Cy5-dUTP(적색)로 표지화하였다. 이때 두 시료는 Microcon YM-30 컬럼(Millipore, USA)을 사용하여 혼합, 정제되었다. Total RNA isolated from control HepG2 cell line was labeled with Cy3-dUTP (green), and RNA isolated from naphthalene treated HepG2 cell line was labeled with Cy5-dUTP (red). At this time, the two samples were mixed and purified using a Microcon YM-30 column (Millipore, USA).
<2-3> <2-3> 혼성화Hybridization 반응 reaction
혼성화 및 세척 과정은 지노첵(주)의 지시방법에 따라 수행되었다. 혼성화는 12시간 동안 62℃ 오븐에서 수행되었다. DNA 마이크로어레이 칩으로는 44 k Whole Human Genome Oligo Microarray(Agilent, USA)를 이용하였다. 세척(2분간 2× SSC/0.1% SDS에 세척, 3분간 1× SSC, 2분간 0.2× SSC에 세척) 후 슬라이드는 3분간 800 rpm으로 원심분리하여 건조하였다. Hybridization and washing procedures were carried out according to the instructions of Genome Co., Ltd .. Hybridization was performed in a 62 ° C. oven for 12 hours. 44 k Whole Human Genome Oligo Microarray (Agilent, USA) was used as the DNA microarray chip. After washing (washing in 2 × SSC / 0.1% SDS for 2 minutes, washing in 1 × SSC for 3 minutes, 0.2 × SSC for 2 minutes), the slides were dried by centrifugation at 800 rpm for 3 minutes.
<2-4> 형광 이미지 획득<2-4> Fluorescence Image Acquisition
슬라이드 상의 혼성화 이미지는 Genepix 4000B(Axon Instruments, USA)로 스캔하였다. 결합하지 않은 유전자를 세척한 칩은 레이저 광 스캐너(laser fluorescence scanner)를 사용하여 형광 이미지를 획득하였다. 이때 녹색 형광 이미지는 대조군에서, 적색 형광 이미지는 실험군에서만 특이하게 발현되는 유전자의 활성정도를 나타내게 되며, 노란색 형광 이미지는 녹색과 적색의 보색으로 두 군의 발현이 큰 차이가 없음을 의미한다. 스캔한 이미지들은 유전자 발현 비율을 얻기 위하여 GenePix 4.1 소프트웨어(Axon Instruments, USA)로 분석하였다. 이렇게 하여 얻어진 데이터로부터 나프탈렌에 대한 마커 유전자를 선별하였다(도 2). Hybridization images on the slides were scanned with the Genepix 4000B (Axon Instruments, USA). Chips washed with unbound genes were obtained with a fluorescence image using a laser fluorescence scanner. In this case, the green fluorescence image in the control group, the red fluorescence image represents the activity level of the gene specifically expressed only in the experimental group, and the yellow fluorescence image is the complementary color of green and red, which means that there is no significant difference between the two groups. Scanned images were analyzed with GenePix 4.1 software (Axon Instruments, USA) to obtain gene expression rates. The marker gene for naphthalene was selected from the data thus obtained (FIG. 2).
그 결과, 올리고 칩 상에 존재하는 대략 4만 4천 개의 유전자 중에서 나프탈렌에 의해 Cy5/Cy3의 비율이 2.0배 이상으로 유전자 발현 증가를 보이는 유전자는 0.86%(44,000개의 유전자 중 377개) 발현이 감소된 유전자는 0.71%(44,000개의 유전자 중 313개)임을 확인하였다. As a result, among the approximately 44,000 genes present on the oligo chip, naphthalene decreased the expression of Cy5 / Cy3 by 2.0 times or more, decreasing the expression of 0.86% (377 of 44,000 genes). The gene was identified as 0.71% (313 out of 44,000 genes).
이때, 나프탈렌에 의해 2배 이상 과발현 혹은 저발현 되는 유전자들을 기능별로 분류한 결과, 세포 주기(cell cycle), 세포 성장(cell growth), 세포 이동(cell migration), 아팝토시스(apoptosis), 전사(transcription), 뉴클레오티드 결합(nucleotide binding), 금속원소 결합(metal binding), 자극에 대한 반응(Response to stimulus), 징크-핑거(Zinc-finger), 단백질 전달(protein transport), 면역반응(immune response), MAPKinase 신호 경로(MAPKinase signaling Pathway), WNT 신호 경로(WNT signaling pathway), 지방산 대사(fatty acid metabolism), 지질 대사(lipid metabolism), 사이토크롬에 의한 외부물질의 대사(metabolism of xenobiotics by cytochrome), 알코올 대사(Alcohol metabolism), DNA 손상 반응(response to DNA damage stimulus) 또는 갭 결합(Gap Junction)등의 관련 유전자로 선별되었다(표 2 및 3). 상기 유전자들은 본 발명에서 사용한 나프탈렌을 처리 했을 때, 인간 간암 세포에서 독성과 관련이 있다는 보고는 없다. At this time, the genes overexpressed or underexpressed by naphthalene were classified by function, and thus, cell cycle, cell growth, cell migration, apoptosis, and transcription. transcription, nucleotide binding, metal binding, response to stimulus, zinc-finger, protein transport, immune response ), MAPKinase signaling pathway, WNT signaling pathway, fatty acid metabolism, lipid metabolism, and metabolism of cytochrome by cytochrome And related genes such as alcohol metabolism, response to DNA damage stimulus, or gap junction (Table 2 and 3). The genes are not reported to be associated with toxicity in human liver cancer cells when treated with naphthalene used in the present invention.
<< 실시예Example 3> 실시간 3> Real time RTRT -PCR(-PCR ( RealReal -- timetime reversereverse transcriptasetranscriptase polymerasepolymerase chain chain reactionreaction ) 정량Quantification
나프탈렌에 의해 발현 유도된 상기 <실시예 2>의 2배 이상 과발현 및 저발현된 유전자 중 나프탈렌에 의해 과발현되는 유전자 24종과 저발현 되는 유전자 21종을 선별하였다. 이들 유전자들은 유전자 등록번호(Genebank) BM913048(TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) BU945318(metallothionein 2A), 유전자 등록번호(Genebank) BM926478(Retinol binding protein 1, cellular), 유전자 등록번호(Genebank) X02812(Transforming growth factor, beta 1(Camurati-Engelmann disease)), 유전자 등록번호(Genebank) NM_004864(Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_003897(Immediate early response 3), 유전자 등록번호(Genebank) BC042390(Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)), 유전자 등록번호(Genebank) NM_017572(MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) NM_173481(Chromosome 19 open reading frame 21), 유전자 등록번호(Genebank) NM_032468(Aspartate beta-hydroxylase), 유전자 등록번호(Genebank) AY247738(Tribbles homolog 3(Drosophila)), 유전자 등록번호(Genebank) AK095363(Aquaporin 3), 유전자 등록번호(Genebank) AA669162(Adenosine monophosphate deaminase(isoform E)), 유전자 등록번호(Genebank) NM_003516(Histone 2, H2aa), 유전자 등록번호(Genebank) NM_003255(TIMP metallopeptidase inhibitor 2), 유전자 등록번호(Genebank) NM_080388(S100 calcium binding protein A16), 유전자 등록번호(Genebank) BX649164(serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_001013632(polo-like kinase 3(Drosophila)), 유전자 등록번호(Genebank) BQ683841(S100 calcium binding protein A11(calgizzarin)), 유전자 등록번호(Genebank) Y11307(Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) AK094474(Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_001769(CD9 antigen(p24)), 유전자 등록번호(Genebank) BC035124(MSFL2541), 유전자 등록번호(Genebank) NM_000499(Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) AF167706(Cysteine rich transmembrane BMP regulator 1(chordin-like)), 유전자 등록번호(Genebank) AB046861(KIAA1641), 유전자 등록번호(Genebank) BC068588(Similar to CG32820-PA, isoform A), 유전자 등록번호(Genebank) AY358727(UDP glucuronosyltransferase 2 family, polypeptide A3), 유전자 등록번호(Genebank) NM_017768(Leucine rich repeat containing 40), 유전자 등록번호(Genebank) AA074156(Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [Mus musculus]), 유전자 등록번호(Genebank) XM_291202(Zinc finger protein 479), 유전자 등록번호(Genebank) AB013380(ATP-binding cassette, sub-family B(MDR/TAP), member 10), 유전자 등록번호(Genebank) NM_180991(Solute carrier organic anion transporter family, member 4C1), 유전자 등록번호(Genebank) BC022255(Spindle pole body component 25 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) AK074377(Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) BX640965(Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) CR600021(High-mobility group box 2), 유전자 등록번호(Genebank) NM_006101(Kinetochore associated 2), 유전자 등록번호(Genebank) NM_145697(Cell division cycle associated 1), 유전자 등록번호(Genebank) AB091343(Centrosomal protein 55kDa), 유전자 등록번호(Genebank) BX640888(Glypican 6), 유전자 등록번호(Genebank) NM_018492(PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK protein kinase), 유전자 등록번호(Genebank) U65410(MAD2 mitotic arrest deficient-like 1(yeast)), 유전자 등록번호(Genebank) NM_001067(Topoisomerase(DNA) II alpha 170kDa)이다.Of the genes overexpressed and underexpressed more than two times as in <Example 2>, which were induced by naphthalene, 24 genes overexpressed by naphthalene and 21 genes underexpressed were selected. These genes are genebank BM913048 (TIMP metallopeptidase inhibitor 1), genebank (Genebank) BU945318 (metallothionein 2A), genebank BM926478 (Retinol binding protein 1, cellular), genebank (Genebank) X02812 (Transforming growth factor, beta 1 (Camurati-Engelmann disease)), Genebank (Genebank) NM_004864 (Growth differentiation factor 15), Genebank (Genebank) NM_003897 (Immediate early response 3), Genebank (Genebank) ) BC042390 (Vesicle transport through interaction with t-SNAREs homolog 1B (yeast), Genebank NM_017572 (MAP kinase interacting serine / threonine kinase 2), Genebank NM_173481 (Chromosome 19 open reading frame 21 ), Gene Registration Number (Genebank) NM_032468 (Aspartate beta-hydroxylase), Gene Registration Number (Genebank) AY247738 (Tribbles homolog 3 (Drosophila)), Gene Registration Number (Genebank) AK095363 (Aquaporin 3), Gene Genebank AA669162 (Adenosine monophosphate deaminase (isoform E)), Gene Registration Number (Genebank) NM_003516 (Histone 2, H2aa), Gene Registration Number (Genebank) NM_003255 (TIMP metallopeptidase inhibitor 2), Gene Registration Number (Genebank) NM_080388 (S100 calcium binding protein A16), gene registration number (Genebank) BX649164 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1), gene registration number (Genebank) NM_001013632 (polo-like kinase 3 (Drosophila), Genebank BQ683841 (S100 calcium binding protein A11 (calgizzarin)), Genebank Number (Genebank) Y11307 (Cysteine-rich, angiogenic inducer, 61), Genebank AK094474 (Ras) homolog gene family, member C), gene registration number (Genebank) NM_001769 (CD9 antigen (p24)), gene registration number (Genebank) BC035124 (MSFL2541), gene registration number (Genebank) NM_000499 (Cytochrome P450, family 1, subfamily A , polypeptide 1), gene registration number (G enebank) AF167706 (Cysteine rich transmembrane BMP regulator 1 (chordin-like)), gene registration number (Genebank) AB046861 (KIAA1641), gene registration number (Genebank) BC068588 (Similar to CG32820-PA, isoform A), gene registration number ( Genebank) AY358727 (UDP glucuronosyltransferase 2 family, polypeptide A3), gene accession number (Genebank) NM_017768 (Leucine rich repeat containing 40), gene accession number (Genebank) AA074156 (Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [ Mus musculus]), Genebank XM_291202 (Zinc finger protein 479), Genebank AB013380 (ATP-binding cassette, sub-family B (MDR / TAP), member 10), Gene registry number ( Genebank) NM_180991 (Solute carrier organic anion transporter family, member 4C1), Gene accession number (Genebank) BC022255 (Spindle pole body component 25 homolog (S. cerevisiae)), Genebank AK074377 (Chromosome 19 open reading frame 31), Gene Registration Number (Genebank) BX640965 (Solute carrier family 22 (extraneuronal monoamine transporter), member 3), Gene Registration Number (Genebank) CR600021 ( High-mobility group box 2), Genebank NM_006101 (Kinetochore associated 2), Genebank NM_145697 (Cell division cycle associated 1), Genebank AB091343 (Centrosomal protein 55kDa), Gene Registration Number (Genebank) BX640888 (Glypican 6), Gene Registration Number (Genebank) NM_018492 (PDZ binding kinase), Gene Registration Number (Genebank) NM_003318 (TTK protein kinase), Gene Registration Number (Genebank) U65410 (MAD2 mitotic arrest deficient- like 1 (yeast), Genebank NM_001067 (Topoisomerase (DNA) II alpha 170kDa).
상기 유전자들의 발현변화 정도를 조사 및 정량하기 위해 My IQ 실시간 PCR(My IQ Real-time PCR)(Bio-rad, USA)을 이용하여 정량적인 실시간 RT-PCR을 실시하였다.Quantitative real-time RT-PCR was performed using My IQ Real-time PCR (Bio-rad, USA) to investigate and quantify the expression changes of the genes.
구체적으로, 올리고 dT 프라이머와 Superscript kit(Omniscipt™ kit, Qiagen, Co., USA)를 이용하여 역전사반응을 수행하여 cDNA를 합성하였다. PCR 산물을 정량하기 위하여 사이버그린(SYBR Green) I 염색(Bio-rad, USA)으로 염색하였다. 사이버그린 I 염색은 이중나선 DNA에 결합하는 염색법으로서, PCR 과정 동안 이중나선 DNA가 생성될수록 형광강도(fluroscense intensity)가 증가하게 된다. Specifically, cDNA was synthesized by performing reverse transcription using an oligo dT primer and a Superscript kit (Omniscipt ™ kit, Qiagen, Co., USA). To quantify the PCR products were stained with SYBR Green I stain (Bio-rad, USA). Cyberrin I staining is a staining method that binds to double-stranded DNA. As the double-stranded DNA is generated during PCR, the fluorescence intensity increases.
먼저, PCR에 이용한 표적 유전자와 내재성(endogenous) 대조군(GAPDH)에 대한 프라이머를 사이버그린 마스터 믹스(Master mix)에 첨가하여 PCR을 실시한 후, 적절한 농도를 선택하는 프라이머 적합화(primer optimization) 과정을 수행하였다. 합성된 cDNA 시료와 각각의 프라이머(표 4)를 혼합하고, 사이버그린 마스터 믹스를 첨가한 후 PCR를 수행하였고, 정량 소프트웨어(software)를 사용하여 분석하였다(표 5).First, a primer optimization process is performed by adding primers for a target gene and an endogenous control (GAPDH) used for PCR to the cybervirin master mix, and then selecting an appropriate concentration. Was performed. Synthesized cDNA samples and each primer (Table 4) were mixed, PCR was performed after the addition of the Cyberrin master mix and analyzed using quantification software (Table 5).
그 결과, 24종의 과발현 유전자들 및 21종의 저발현 유전자의 유전자 발현 양상은 나프탈렌에 의한 유전자 발현을 조사한 올리고 마이크로어레이 결과와 매우 유사하게 나타남을 확인하였다.As a result, it was confirmed that the gene expression patterns of 24 overexpression genes and 21 low expression genes were very similar to those of oligo microarrays which examined gene expression by naphthalene.
도 1은 나프탈렌(Naphthalene)의 인간 간암 세포주에서의 세포 독성을 나타내는 그래프이다.1 is a graph showing cytotoxicity of Naphthalene in human liver cancer cell line.
도 2는 마이크로어레이 칩을 이용한 나프탈렌을 처리한 인간 간암 세포주의 유전자 발현 양상을 분석한 결과를 나타내는 그림이다.Figure 2 is a diagram showing the results of analyzing the gene expression pattern of human liver cancer cell line treated with naphthalene using a microarray chip.
<110> Korea Institute of Science and Technology <120> Biomarker for identification of exposure to naphthalene and the method of identification using thereof <130> 8p-02-06 <160> 90 <170> KopatentIn 1.71 <210> 1 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 1 sense primer <400> 1 gatacttcca caggtcccac aac 23 <210> 2 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 1 antisense primer <400> 2 gcaagagtcc atcctgcagt t 21 <210> 3 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> metallothionein 2A sense primer <400> 3 ctctagccgc ctcttcagc 19 <210> 4 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> metallothionein 2A antisense primer <400> 4 actctttgca tttgcaggaa c 21 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Retinol binding protein 1, cellular sense primer <400> 5 aggcatagat gaccgcaagt 20 <210> 6 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Retinol binding protein 1, cellular antisense primer <400> 6 acccttctgc acacactgg 19 <210> 7 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Transforming growth factor, beta 1 sense primer <400> 7 gcagcacgtg gagctgta 18 <210> 8 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Transforming growth factor, beta 1 antisense primer <400> 8 cagccggttg ctgaggta 18 <210> 9 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Growth differentiation factor 15 sense primer <400> 9 cctgagacac ccgattcct 19 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Growth differentiation factor 15 antisense primer <400> 10 acagttccat cagaccagcc 20 <210> 11 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Immediate early response 3 sense primer <400> 11 agccctttaa tctgacttcg gagc 24 <210> 12 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Immediate early response 3 antisense primer <400> 12 caggtacgcc tggtgtttct ttgt 24 <210> 13 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Vesicle transport through interaction with t-SNAREs homolog 1B sense primer <400> 13 gggggactaa cctatcgaga a 21 <210> 14 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Vesicle transport through interaction with t-SNAREs homolog 1B antisense primer <400> 14 gatccagtgc tgatagcaac c 21 <210> 15 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> MAP kinase interacting serine/threonine kinase 2 sense primer <400> 15 ccatggtcct gcagaggt 18 <210> 16 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> MAP kinase interacting serine/threonine kinase 2 antisense primer <400> 16 ttctgaccag tcctccaggt 20 <210> 17 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 21 sense primer <400> 17 tcggacggta tcaactcaga 20 <210> 18 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 21 antisense primer <400> 18 tcctcctcac tggcgtagat 20 <210> 19 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aspartate beta-hydroxylase sense primer <400> 19 tgctgatgca gacctatcca ggaa 24 <210> 20 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aspartate beta-hydroxylase antisense primer <400> 20 tgtcatcttt gtctcgggat gcca 24 <210> 21 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Tribbles homolog 3 sense primer <400> 21 gtcttcgctg accgtgaga 19 <210> 22 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Tribbles homolog 3 antisense primer <400> 22 cagtcagcac gcaggagtc 19 <210> 23 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aquaporin 3 sense primer <400> 23 ttcacgatcc accctttcag gcta 24 <210> 24 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aquaporin 3 antisense primer <400> 24 acacatacct gctgcccatt ctct 24 <210> 25 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Adenosine monophosphate deaminase sense primer <400> 25 aggtcaaaga agctgctgcc aaac 24 <210> 26 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Adenosine monophosphate deaminase antisense primer <400> 26 tggactcatc atccacgctg tcaa 24 <210> 27 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Histone 2, H2aa sense primer <400> 27 gaactgaaca agctgctggg caaa 24 <210> 28 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Histone 2, H2aa antisense primer <400> 28 tctccgtctt cttagggagc agta 24 <210> 29 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 2 sense primer <400> 29 cgacatttat ggcaacccta tca 23 <210> 30 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 2 antisense primer <400> 30 caggcccttt gaacatcttt atct 24 <210> 31 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A16 sense primer <400> 31 ccagaaagag ctgaaccaca tgct 24 <210> 32 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A16 antisense primer <400> 32 aggtccagta ctcatcgaag ctga 24 <210> 33 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 snese primer <400> 33 cagaccaaga gcctctccac 20 <210> 34 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1 antisense primer <400> 34 atcacttggc ccatgaaaag 20 <210> 35 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> polo-like kinase 3 (Drosophila) snese primer <400> 35 gactactcca ataagttcgg ctttg 25 <210> 36 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> polo-like kinase 3 (Drosophila) antisense primer <400> 36 catatgtgtg ccatcgttga aga 23 <210> 37 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A11 (calgizzarin) sense primer <400> 37 agtccctgat tgctgtcttc caga 24 <210> 38 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A11 (calgizzarin) antisense primer <400> 38 accagggtcc ttctggttct ttgt 24 <210> 39 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Cysteine-rich, angiogenic inducer, 61 snese primer <400> 39 attgtagaaa ggaagccttg ctcat 25 <210> 40 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Cysteine-rich, angiogenic inducer, 61 antisense primer <400> 40 tccaatcgtg gctgcattag 20 <210> 41 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Ras homolog gene family, member C sense primer <400> 41 acctgcctcc tcatcgtctt c 21 <210> 42 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Ras homolog gene family, member C antisense primer <400> 42 cacctgcttg ccgtccac 18 <210> 43 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> CD9 antigen (p24) sense primer <400> 43 gcaccaagtg catcaaatac ctgc 24 <210> 44 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> CD9 antigen (p24) antisense primer <400> 44 agccatagtc caatggcaag gaca 24 <210> 45 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> MSFL2541 sense primer <400> 45 ttcgccgtcc tttacatcta c 21 <210> 46 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> MSFL2541 antisense primer <400> 46 agagcctggg gactcacat 19 <210> 47 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Cytochrome P450, family 1, subfamily A, polypeptide 1 sense primer <400> 47 caccatcccc cacagcac 18 <210> 48 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Cytochrome P450, family 1, subfamily A, polypeptide 1 antisense primer <400> 48 acaaagacac aacgcccctt 20 <210> 49 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cysteine rich transmembrane BMP regulator 1(chordin-like) sense primer <400> 49 tgcccacagt gtacagatca acct 24 <210> 50 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cysteine rich transmembrane BMP regulator 1(chordin-like) antisense primer <400> 50 atgcagatgc agctggtaca aacg 24 <210> 51 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> KIAA1641 sense primer <400> 51 aaggagggac aacaatctgg gaca 24 <210> 52 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> KIAA1641 antisense primer <400> 52 tcacttgtag cctttgaggg tggt 24 <210> 53 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Similar to CG32820-PA, isoform A sense primer <400> 53 atagcatcgg gcaggactaa tgga 24 <210> 54 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Similar to CG32820-PA, isoform A antisense primer <400> 54 gaaagagggt gtgatgtgga ccat 24 <210> 55 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> UDP glucuronosyltransferase 2 family, polypeptide A3 snese primer <400> 55 gaaaaggcta atatcattgc ttcag 25 <210> 56 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> UDP glucuronosyltransferase 2 family, polypeptide A3 antisense primer <400> 56 ttcctttgta cctccataac acc 23 <210> 57 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Leucine rich repeat containing 40 sense primer <400> 57 tgccgcagtg tgtctggaga ataa 24 <210> 58 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Leucine rich repeat containing 40 antisense primer <400> 58 tgctcccacc atctttcagt agca 24 <210> 59 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B[Mus musculus] sense primer <400> 59 aggctggaac ctatttgcct cagt 24 <210> 60 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B[Mus musculus] antisense primer <400> 60 tgcgaaacaa ttgctggctt cacg 24 <210> 61 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Zinc finger protein 479 sense primer <400> 61 atggtagcca aacacccagt 20 <210> 62 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Zinc finger protein 479 antisense primer <400> 62 tgaatctttg atgccctgct 20 <210> 63 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> ATP-binding cassette, sub-family B (MDR/TAP), member 10 sense primer <400> 63 tcagcctttc cattccgtca ggat 24 <210> 64 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> ATP-binding cassette, sub-family B (MDR/TAP), member 10 antisense primer <400> 64 tttggatctc agccacactg ggtt 24 <210> 65 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier organic anion transporter family, member 4C1 sense primer <400> 65 ccagcttcgc agctactctt 20 <210> 66 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier organic anion transporter family, member 4C1 antisense primer <400> 66 ccacctaaaa tttgaccgag ag 22 <210> 67 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Spindle pole body component 25 homolog (S. cerevisiae) sense primer <400> 67 gaatggttga gatgtttctg ga 22 <210> 68 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> Spindle pole body component 25 homolog (S. cerevisiae) antisense primer <400> 68 gcaatcaatt ttaacaagtt atccttt 27 <210> 69 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 31 sense primer <400> 69 ctggtacgac gcggagat 18 <210> 70 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 31 antisense primer <400> 70 cgacagtcgt tcagagaatc a 21 <210> 71 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier family 22(extraneuronal monoamine transporter), member 3 sense primer <400> 71 gccctgttcc agcaataaga 20 <210> 72 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier family 22(extraneuronal monoamine transporter), member 3 antisense primer <400> 72 gagagccaaa aatgtcccaa 20 <210> 73 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> High-mobility group box 2 sense primer <400> 73 cttggcacga tatgcagcaa 20 <210> 74 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> High-mobility group box 2 antisense primer <400> 74 cagccaaaga taaacaacca tatga 25 <210> 75 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Kinetochore associated 2 sense primer <400> 75 tgctacacat gttgggtctg ta 22 <210> 76 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Kinetochore associated 2 antisense primer <400> 76 ccgagagatc ttctgacatg c 21 <210> 77 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cell division cycle associated 1 sense primer <400> 77 tgccttcatg tcagttggaa gtgc 24 <210> 78 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cell division cycle associated 1 antisense primer <400> 78 tttggtcctc caagttcagg ctct 24 <210> 79 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Centrosomal protein 55 kDa sense primer <400> 79 gctgtgcatt tctcttggca gtga 24 <210> 80 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Centrosomal protein 55 kDa antisense primer <400> 80 tagacgctgc tcaccacatt ctgt 24 <210> 81 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Glypican 6 sense primer <400> 81 acactgacca gctcaagcca tttg 24 <210> 82 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Glypican 6 antisense primer <400> 82 gacaaaggtc ctggcagcaa tgaa 24 <210> 83 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> PDZ binding kinase antisense primer <400> 83 tctggactga gagtggcttt caca 24 <210> 84 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> PDZ binding kinase antisense primer <400> 84 agccaagctt ctgcataaac ggag 24 <210> 85 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TTK protein kinase sense primer <400> 85 tcatgcccat ttggaagagt ccca 24 <210> 86 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TTK protein kinase antisense primer <400> 86 aggcacaacc aaatctcggc attc 24 <210> 87 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> MAD2 mitotic arrest deficient-like 1(yeast) sense primer <400> 87 acttaaatat ctccctacct atactgagtc aa 32 <210> 88 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> MAD2 mitotic arrest deficient-like 1(yeast) antisense primer <400> 88 tagtaactgt agatggaaaa acttgtgcta 30 <210> 89 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Topoisomerase(DNA) II alpha 170 kDa sense primer <400> 89 ctagttaatg ctgcggacaa ca 22 <210> 90 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Topoisomerase(DNA) II alpha 170 kDa antisense primer <400> 90 catttcgacc acctgtcact t 21 <110> Korea Institute of Science and Technology <120> Biomarker for identification of exposure to naphthalene and the method of identification using <130> 8p-02-06 <160> 90 <170> KopatentIn 1.71 <210> 1 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 1 sense primer <400> 1 gatacttcca caggtcccac aac 23 <210> 2 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 1 antisense primer <400> 2 gcaagagtcc atcctgcagt t 21 <210> 3 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> metallothionein 2A sense primer <400> 3 ctctagccgc ctcttcagc 19 <210> 4 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> metallothionein 2A antisense primer <400> 4 actctttgca tttgcaggaa c 21 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Retinol binding protein 1, cellular sense primer <400> 5 aggcatagat gaccgcaagt 20 <210> 6 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Retinol binding protein 1, cellular antisense primer <400> 6 acccttctgc acacactgg 19 <210> 7 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Transforming growth factor, beta 1 sense primer <400> 7 gcagcacgtg gagctgta 18 <210> 8 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Transforming growth factor, beta 1 antisense primer <400> 8 cagccggttg ctgaggta 18 <210> 9 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Growth differentiation factor 15 sense primer <400> 9 cctgagacac ccgattcct 19 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Growth differentiation factor 15 antisense primer <400> 10 acagttccat cagaccagcc 20 <210> 11 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Immediate early response 3 sense primer <400> 11 agccctttaa tctgacttcg gagc 24 <210> 12 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Immediate early response 3 antisense primer <400> 12 caggtacgcc tggtgtttct ttgt 24 <210> 13 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Vesicle transport through interaction with t-SNAREs homolog 1B sense primer <400> 13 gggggactaa cctatcgaga a 21 <210> 14 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Vesicle transport through interaction with t-SNAREs homolog 1B antisense primer <400> 14 gatccagtgc tgatagcaac c 21 <210> 15 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> MAP kinase interacting serine / threonine kinase 2 sense primer <400> 15 ccatggtcct gcagaggt 18 <210> 16 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> MAP kinase interacting serine / threonine kinase 2 antisense primer <400> 16 ttctgaccag tcctccaggt 20 <210> 17 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 21 sense primer <400> 17 tcggacggta tcaactcaga 20 <210> 18 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 21 antisense primer <400> 18 tcctcctcac tggcgtagat 20 <210> 19 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aspartate beta-hydroxylase sense primer <400> 19 tgctgatgca gacctatcca ggaa 24 <210> 20 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aspartate beta-hydroxylase antisense primer <400> 20 tgtcatcttt gtctcgggat gcca 24 <210> 21 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Tribbles homolog 3 sense primer <400> 21 gtcttcgctg accgtgaga 19 <210> 22 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Tribbles homolog 3 antisense primer <400> 22 cagtcagcac gcaggagtc 19 <210> 23 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aquaporin 3 sense primer <400> 23 ttcacgatcc accctttcag gcta 24 <210> 24 <211> 24 <212> DNA <213> Artificial Sequence <220> Aquaporin 3 antisense primer <400> 24 acacatacct gctgcccatt ctct 24 <210> 25 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Adenosine monophosphate deaminase sense primer <400> 25 aggtcaaaga agctgctgcc aaac 24 <210> 26 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Adenosine monophosphate deaminase antisense primer <400> 26 tggactcatc atccacgctg tcaa 24 <210> 27 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Histone 2, H2aa sense primer <400> 27 gaactgaaca agctgctggg caaa 24 <210> 28 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Histone 2, H2aa antisense primer <400> 28 tctccgtctt cttagggagc agta 24 <210> 29 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 2 sense primer <400> 29 cgacatttat ggcaacccta tca 23 <210> 30 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 2 antisense primer <400> 30 caggcccttt gaacatcttt atct 24 <210> 31 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A16 sense primer <400> 31 ccagaaagag ctgaaccaca tgct 24 <210> 32 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A16 antisense primer <400> 32 aggtccagta ctcatcgaag ctga 24 <210> 33 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 snese primer <400> 33 cagaccaaga gcctctccac 20 <210> 34 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 antisense primer <400> 34 atcacttggc ccatgaaaag 20 <210> 35 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> polo-like kinase 3 (Drosophila) snese primer <400> 35 gactactcca ataagttcgg ctttg 25 <210> 36 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> polo-like kinase 3 (Drosophila) antisense primer <400> 36 catatgtgtg ccatcgttga aga 23 <210> 37 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A11 (calgizzarin) sense primer <400> 37 agtccctgat tgctgtcttc caga 24 <210> 38 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A11 (calgizzarin) antisense primer <400> 38 accagggtcc ttctggttct ttgt 24 <210> 39 <211> 25 <212> DNA <213> Artificial Sequence <220> Cysteine-rich, angiogenic inducer, 61 snese primer <400> 39 attgtagaaa ggaagccttg ctcat 25 <210> 40 <211> 20 <212> DNA <213> Artificial Sequence <220> Cysteine-rich, angiogenic inducer, 61 antisense primer <400> 40 tccaatcgtg gctgcattag 20 <210> 41 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Ras homolog gene family, member C sense primer <400> 41 acctgcctcc tcatcgtctt c 21 <210> 42 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Ras homolog gene family, member C antisense primer <400> 42 cacctgcttg ccgtccac 18 <210> 43 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> CD9 antigen (p24) sense primer <400> 43 gcaccaagtg catcaaatac ctgc 24 <210> 44 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> CD9 antigen (p24) antisense primer <400> 44 agccatagtc caatggcaag gaca 24 <210> 45 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> MSFL2541 sense primer <400> 45 ttcgccgtcc tttacatcta c 21 <210> 46 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> MSFL2541 antisense primer <400> 46 agagcctggg gactcacat 19 <210> 47 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Cytochrome P450, family 1, subfamily A, polypeptide 1 sense primer <400> 47 caccatcccc cacagcac 18 <210> 48 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Cytochrome P450, family 1, subfamily A, polypeptide 1 antisense primer <400> 48 acaaagacac aacgcccctt 20 <210> 49 <211> 24 <212> DNA <213> Artificial Sequence <220> Cysteine rich transmembrane BMP regulator 1 (chordin-like) sense primer <400> 49 tgcccacagt gtacagatca acct 24 <210> 50 <211> 24 <212> DNA <213> Artificial Sequence <220> Cysteine rich transmembrane BMP regulator 1 (chordin-like) antisense primer <400> 50 atgcagatgc agctggtaca aacg 24 <210> 51 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> KIAA1641 sense primer <400> 51 aaggagggac aacaatctgg gaca 24 <210> 52 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> KIAA1641 antisense primer <400> 52 tcacttgtag cctttgaggg tggt 24 <210> 53 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Similar to CG32820-PA, isoform A sense primer <400> 53 atagcatcgg gcaggactaa tgga 24 <210> 54 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Similar to CG32820-PA, isoform A antisense primer <400> 54 gaaagagggt gtgatgtgga ccat 24 <210> 55 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> UDP glucuronosyltransferase 2 family, polypeptide A3 snese primer <400> 55 gaaaaggcta atatcattgc ttcag 25 <210> 56 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> UDP glucuronosyltransferase 2 family, polypeptide A3 antisense primer <400> 56 ttcctttgta cctccataac acc 23 <210> 57 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Leucine rich repeat containing 40 sense primer <400> 57 tgccgcagtg tgtctggaga ataa 24 <210> 58 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Leucine rich repeat containing 40 antisense primer <400> 58 tgctcccacc atctttcagt agca 24 <210> 59 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [Mus musculus] sense primer <400> 59 aggctggaac ctatttgcct cagt 24 <210> 60 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [Mus musculus] antisense primer <400> 60 tgcgaaacaa ttgctggctt cacg 24 <210> 61 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Zinc finger protein 479 sense primer <400> 61 atggtagcca aacacccagt 20 <210> 62 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Zinc finger protein 479 antisense primer <400> 62 tgaatctttg atgccctgct 20 <210> 63 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> ATP-binding cassette, sub-family B (MDR / TAP), member 10 sense primer <400> 63 tcagcctttc cattccgtca ggat 24 <210> 64 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> ATP-binding cassette, sub-family B (MDR / TAP), member 10 antisense primer <400> 64 tttggatctc agccacactg ggtt 24 <210> 65 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier organic anion transporter family, member 4C1 sense primer <400> 65 ccagcttcgc agctactctt 20 <210> 66 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier organic anion transporter family, member 4C1 antisense primer <400> 66 ccacctaaaa tttgaccgag ag 22 <210> 67 <211> 22 <212> DNA <213> Artificial Sequence <220> Spindle pole body component 25 homolog (S. cerevisiae) sense primer <400> 67 gaatggttga gatgtttctg ga 22 <210> 68 <211> 27 <212> DNA <213> Artificial Sequence <220> Spindle pole body component 25 homolog (S. cerevisiae) antisense primer <400> 68 gcaatcaatt ttaacaagtt atccttt 27 <210> 69 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 31 sense primer <400> 69 ctggtacgac gcggagat 18 <210> 70 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 31 antisense primer <400> 70 cgacagtcgt tcagagaatc a 21 <210> 71 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier family 22 (extraneuronal monoamine transporter), member 3 sense primer <400> 71 gccctgttcc agcaataaga 20 <210> 72 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier family 22 (extraneuronal monoamine transporter), member 3 antisense primer <400> 72 gagagccaaa aatgtcccaa 20 <210> 73 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> High-mobility group box 2 sense primer <400> 73 cttggcacga tatgcagcaa 20 <210> 74 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> High-mobility group box 2 antisense primer <400> 74 cagccaaaga taaacaacca tatga 25 <210> 75 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Kinetochore associated 2 sense primer <400> 75 tgctacacat gttgggtctg ta 22 <210> 76 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Kinetochore associated 2 antisense primer <400> 76 ccgagagatc ttctgacatg c 21 <210> 77 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cell division cycle associated 1 sense primer <400> 77 tgccttcatg tcagttggaa gtgc 24 <210> 78 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cell division cycle associated 1 antisense primer <400> 78 tttggtcctc caagttcagg ctct 24 <210> 79 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Centrosomal protein 55 kDa sense primer <400> 79 gctgtgcatt tctcttggca gtga 24 <210> 80 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Centrosomal protein 55 kDa antisense primer <400> 80 tagacgctgc tcaccacatt ctgt 24 <210> 81 <211> 24 <212> DNA <213> Artificial Sequence <220> Glypican 6 sense primer <400> 81 acactgacca gctcaagcca tttg 24 <210> 82 <211> 24 <212> DNA <213> Artificial Sequence <220> Glypican 6 antisense primer <400> 82 gacaaaggtc ctggcagcaa tgaa 24 <210> 83 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> PDZ binding kinase antisense primer <400> 83 tctggactga gagtggcttt caca 24 <210> 84 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> PDZ binding kinase antisense primer <400> 84 agccaagctt ctgcataaac ggag 24 <210> 85 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TTK protein kinase sense primer <400> 85 tcatgcccat ttggaagagt ccca 24 <210> 86 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TTK protein kinase antisense primer <400> 86 aggcacaacc aaatctcggc attc 24 <210> 87 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> MAD2 mitotic arrest deficient-like 1 (yeast) sense primer <400> 87 acttaaatat ctccctacct atactgagtc aa 32 <210> 88 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> MAD2 mitotic arrest deficient-like 1 (yeast) antisense primer <400> 88 tagtaactgt agatggaaaa acttgtgcta 30 <210> 89 <211> 22 <212> DNA <213> Artificial Sequence <220> Topoisomerase (DNA) II alpha 170 kDa sense primer <400> 89 ctagttaatg ctgcggacaa ca 22 <210> 90 <211> 21 <212> DNA <213> Artificial Sequence <220> Topoisomerase II alpha 170 kDa antisense primer <400> 90 catttcgacc acctgtcact t 21
Claims (15)
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Cited By (3)
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KR101432171B1 (en) * | 2013-01-22 | 2014-08-22 | 한국원자력의학원 | Composition for diagnosis of radio-resistance or radio-sensitive CDK11A marker and use thereof |
KR20200048741A (en) | 2018-10-30 | 2020-05-08 | (주)아모레퍼시픽 | A composition for skin barrier function comprising ELL promoting materials and a method for screening ELL promoting materials |
CN116586048A (en) * | 2023-07-17 | 2023-08-15 | 江苏恰瑞生物科技有限公司 | Modified polystyrene adsorption resin for blood perfusion device and preparation method thereof |
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KR101735415B1 (en) | 2015-07-31 | 2017-05-16 | 한국과학기술연구원 | Methylation marker for identification of exposure to hexanal and the method of identification using thereof |
KR102610577B1 (en) | 2021-11-01 | 2023-12-07 | 동국대학교 산학협력단 | Biomarker for evaluating exposure to Phenol and the evaluation method using the same |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101432171B1 (en) * | 2013-01-22 | 2014-08-22 | 한국원자력의학원 | Composition for diagnosis of radio-resistance or radio-sensitive CDK11A marker and use thereof |
KR20200048741A (en) | 2018-10-30 | 2020-05-08 | (주)아모레퍼시픽 | A composition for skin barrier function comprising ELL promoting materials and a method for screening ELL promoting materials |
CN116586048A (en) * | 2023-07-17 | 2023-08-15 | 江苏恰瑞生物科技有限公司 | Modified polystyrene adsorption resin for blood perfusion device and preparation method thereof |
CN116586048B (en) * | 2023-07-17 | 2023-09-08 | 江苏恰瑞生物科技有限公司 | Modified polystyrene adsorption resin for blood perfusion device and preparation method thereof |
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