KR20090089135A - Composition having brain function and congnition enhancing activity comprising betula platy phylla sap - Google Patents

Abstract

A composition for improving brain function and cognitive function is provided to treat or prevent memory, dementia, amnesia or Alzheimer disease using Betula platy phylla liquid solution. A composition for improving brain function and cognition function comprises Betula platy phylla liquid solution only as an active ingredient and pharmaceutically or sitologically acceptable excipient. The composition is used for treating and preventing damage of memory, dementia, amnesia or Alzheimer disease. A health adjuvant food for improving brain function and cognitive function comprises the composition. The food is selected from the forms of tablet, capsule, powder, granule, liquid and beverage.

Description

Composition having brain function and congnition enhancing activity comprising Betula Platy Phylla sap}

The present invention relates to a composition having a brain function and cognitive function improving activity, and more particularly to a composition for improving brain function and cognitive function containing birch sap as an active ingredient.

As senile dementia has recently been recognized as a degenerative central nervous system disease and the number of patients has increased day by day, it has emerged as a big social problem, and the importance of its prevention, improvement and treatment is newly emerging. Alzheimer's disease is known to be the majority of dementia patients that have recently emerged as social problems. Alzheimer's disease patients suffer from abnormalities in almost all nerves, including cholinergic, adrenergic, GABA and glutamate nerves, and the loss of cholinergic nerves is known to be most serious. Therefore, researches for the development of Alzheimer's disease treatments have been actively conducted to restore or improve cholinergic disorders.

The development of a cure for Alzheimer's disease has been advanced as the method of artificially manipulating the condition similar to Alzheimer's disease by inducing abnormalities in the cholinergic nervous system by administering scopolamine to experimental animals (Flood, J.). and Cherkin, A. Scopolamine effects on memory retention in mice, Behav. Neural. Biol. 45: 169-184 (1986)).

The administration of scopolamine in rats is associated with symptoms similar to those in Alzheimer's disease, including degeneration of cholinergic neurons and loss of memory, as well as deficiencies in acquisition, immediate response, and working memory. Smith, 1988; Giacobini, E. and Cuadra, G. (1994)). These symptoms are Pizo, an acetylcholinesterase (AChE) inhibitor that maintains the concentration of acetylcholine in the cell by inhibiting the degradation of arecoline and oxotremorine or acetylcholine, which are agonists of cholinergic neurons. It was alleviated by the administration of physostigmine and the like. Indeed, tacrine, an AChE inhibitor, has been used in the clinic, but studies such as hepatotoxicity, short half-life, and low bioavailability have been raised.

The present inventors confirmed that birch sap has significant brain and cognitive function improving activity while searching for its activity in natural products to find a substance having new brain function and cognitive function improving activity.

The birch (Betula Platy Phylla) of the present invention is a deciduous tree belonging to the birch family and grows in high mountains north of Gangwon-do but is also distributed in the North Sea of Japan and China. The sap is white, peeled horizontally, and the branch is dark brown with a spot. Leaves regenerate in the intestines and two in the complex. Triangular ovate, 5-7cm long, 4-6cm wide, with acute tip. It is a wide tongue or heart bottom and has a marginal value at the edge. There is almost no hair, but there are some hairs on the leaf fluid on the back of the leaf.

The birch sap is composed mainly of glucose and fructose, and contains small amounts of minerals such as potassium, sodium, magnesium, and zinc, and amino acids (taurine, glycine, lysine, alanine, threonine, etc.), In addition to protein, it consists of organic acids such as malic acid and other unknown constituents. The sap has a sweet, delicious and refreshing taste. In China, birch sap has been collected and used for many years in China, and sap is used as a health drink in Northern Europe. The research on the activity of birch sap is insufficient, and so far, no research on the brain function and cognitive function of birch sap has been conducted. In the present invention, it was surprisingly confirmed that the sap of the birch sap to improve brain function and cognitive function to complete the present invention.

The present invention provides a composition for improving brain function and cognitive function comprising birch sap alone as an active ingredient, or in combination with a pharmaceutically or food-acceptable excipient.

The present invention also provides a food additive, dietary supplement, or a pharmaceutical composition exhibiting a brain and cognitive function improving effect containing a composition comprising birch sap. The dietary supplement or pharmaceutical composition is preferably selected from the group consisting of tablets, capsules, powders, granules, liquids and beverages.

The present invention provides a composition for improving brain function and cognitive function, including birch sap as an active ingredient.

The birch sap of the present invention can be collected from a birch through a conventional harvesting method, or a commercially available birch sap, for example, can be used by purchasing a birch sap (trade name: Happy Walk) of SK Construction. In addition, in order to reduce the change in the collected process of the collected sap, it is obvious that the filtrate processed by the processing means such as filtration, or the sap concentrated or lyophilized powder can also be used as the birch sap of the present invention. .

In the present invention, the birch sap showed excellent brain function and cognitive function improving activity as in the following experimental example.

The composition of the present invention exhibits an effect of improving brain function and / or cognitive function, prevents memory loss, memory impairment, in particular memory impairment associated with deficiency of acquisition and / or loss of activity memory, dementia, forgetfulness, Alzheimer's disease, and the like. It can be used as a therapeutic composition.

The compositions of the present invention may be formulated by methods known in the pharmaceutical or food arts, and may be used alone or in admixture with pharmaceutically acceptable carriers, excipients, etc. For example, it may be formulated as a liquid, syrup, capsule, and the like, which may be administered orally or parenterally.

Liquids, capsules, beverages, etc. comprising the composition of the present invention can be used as a dietary supplement, the term "health supplement" used in the present invention is used as a raw material or ingredient having a useful functionality to the human body Refers to functional foods such as health foods or beverages, yogurt, cheese, etc. manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, and the like.

The composition of the present invention is appropriately selected depending on the absorption of the active ingredient in the body, the rate of excretion, the age and weight of the patient, the sex and condition, the severity of the disease to be treated, etc. In general, a birch sap in a suitable amount, for example, 100 to 200ml It is preferable to drink several times a day at a dose, or to administer the dry powder thereof to an adult at 0.01 to 500 mg / kg, preferably 0.1 to 200 mg / kg per day. The unit dosage form so formulated may be administered several times at regular time intervals as needed.

Hereinafter, the present invention will be described in more detail with reference to the following examples. These examples are for illustrative purposes of the present invention and are not intended to limit the protection scope of the present invention.

Example  One : Test substance

Commercial birch sap (SK Construction Co., Ltd., trade name: Happy Walk) was purchased, concentrated under reduced pressure and lyophilized, and then powdered and used in the following experimental example.

Experimental Example  One

1. Experiment Method

1) Experimental Animal

Seoul National University experimental animal breeding room was supplied with 25-30g of ICR male (male) reared with sufficient water and feed was used for the experiment after being adapted to the laboratory environment for one week.

2) Passive avoidance test

Split the evacuation box (40 X 20 X 20 cm) with a 3 mm thick stainless steel bar at the bottom into a bright and dark room, and 0.2 mA / 10 g through the stainless bar when the mouse in the bright room enters the dark room. I trained to give an electrical stimulus of my weight. After 24 hours, the same test was performed to measure the time the mouse stays in a bright room (Step through latency), and compared with the administration group, the control group, and the control group of Example 1 as an index for remembering the training of the previous day. Scopolamine was dissolved in physiological saline to prepare a solution of 1.5 mg / kg and injected subcutaneously 30 minutes prior to training to cause memory and cognitive impairment, and the birch of Example 1 1 hour 30 minutes before scopolamine administration The sap was dissolved in physiological saline and orally administered at 30 mg / ml, 50 mg / ml, and 100 mg / ml, respectively, to observe the effects on the memory and cognitive impairment induced by scopolamine.

The results are shown in FIG. In Figure 1, "control" corresponds to the normal group not fed both scopolamine and birch sap, "scopolamine" as a control, without treating the birch sap prepared in Example 1 It is the group that treated with only polyamine and caused memory and cognitive impairment.

As shown in Fig. 1, step through when birch sap was ingested at 30 mg / ml, 50 mg / ml, and 100 mg / ml in a passive avoidance reaction test of mice induced memory and cognitive impairment induced by scopolamine. The recovery rate increased to 35.5%, 53.3%, and 76.4%, depending on the concentration. Thus, it can be seen that birch sap has a significant effect on memory and cognitive impairment.

Composition Example

Composition example  1. Preparation of Capsule

200 mg of birch sap of Example 1

Lactose 100mg

Starch 93mg

Talc 2mg

Magnesium stearate proper amount

The capsules are prepared by mixing the above components and filling gelatin capsules according to a conventional method for preparing capsules.

Composition example  2. Preparation of Capsule

100 mg of birch sap of Example 1

Lactose 100mg

Starch 93mg

Talc 2mg

Magnesium stearate proper amount

The capsules are prepared by mixing the above components and filling gelatin capsules according to a conventional method for preparing capsules.

1 is a view showing the memory recovery effect on the birch sap of the present invention.

Claims (5)

A composition for improving brain function and cognitive function comprising birch sap alone as an active ingredient or together with a pharmaceutically or food-acceptable excipient. The composition of claim 1, wherein the composition is for the treatment or prevention of memory impairment associated with loss of memory, deficiency of acquisition and loss of activity memory, dementia, forgetfulness or Alzheimer's disease. Health supplement foods for improving brain function and cognitive function containing the composition of claim 1. The dietary supplement of claim 3, wherein the dietary supplement is selected from the group consisting of tablets, capsules, powders, granules, liquids and beverages. A pharmaceutical composition for improving brain function and cognitive function containing the composition of claim 1.

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