KR20090046011A - The cosmetic composition - Google Patents

Abstract

The present invention relates to a cosmetic composition containing moringa seed extract and pombulin to protect the skin from contaminated environments and ultraviolet rays, the cosmetic composition is excellent in the skin protection effect against heavy metals and tobacco smoke, contaminants and With the efficacy of Moringa seed extract, which has the ability to cleanse the skin damaged from UV rays, and form a film when applying the skin, it prevents harmful substances from contacting the skin and restores the damaged skin due to irritation. Due to this, it not only protects the skin from external harmful factors such as yellow dust, smog, tobacco smoke, ultraviolet rays, etc., and may also help to restore damaged skin.

Moringa, Pomblin, Anti-Pollution, Skin Protection, Cosmetics, Composition

Description

The cosmetic composition

The present invention relates to a cosmetic composition containing Moringa seeds Extract and Pomblin to protect the skin from contaminated environments and ultraviolet rays. The cosmetic composition protects the skin against heavy metals and tobacco smoke. Excellent effect, Moringa seed extract with the ability to cleanse the skin damaged by contaminants and ultraviolet rays and forms a film when applying the skin to prevent harmful substances from contacting the skin, and to remove damaged skin due to irritation Due to the healing effect of Pomblein, it not only protects the skin from external harmful factors such as yellow dust, smog, tobacco smoke, ultraviolet rays, etc., and can also help to restore damaged skin.

The skin is a protective film that protects the human body from the external environment and plays a role of protecting the human body from external harmful substances and ultraviolet rays. However, due to the rapid industrialization, the ozone layer is destroyed, and the increase of ultraviolet rays due to the destruction of the ozone layer, inflow of yellow sand containing heavy metals, smog caused by air pollution, tobacco smoke, and the like have a detrimental effect on the skin.

In general, the ultraviolet rays included in the sun rays are divided into long wavelength ultraviolet rays (UVA, 320 to 400 nm), medium wavelength ultraviolet rays (UVB, 280 to 320 nm), and short wavelength ultraviolet rays (UVC, 200 to 280 nm) according to their wavelength ranges. Ultraviolet rays are known to cause various side effects on the skin. Ultraviolet rays not only cause skin aging, but also cause pigmentation such as blemishes and freckles, blotch, and skin cancer. Moreover, UV rays reach 80% of the earth's surface even in shade or cloudy days, and pass through almost all glass, including automotive and house glass. In addition, in the case of clothes, synthetic fibers have little blocking effect, and only 70% of natural fibers such as cotton products are blocked.

In the yellow sand, silicon, aluminum, potassium, calcium, etc., which are industrial wastes, are mixed a lot, and when nitrogen oxides and sulfur oxides are produced and stuck to the skin by chemical reactions in the air, itching and itching can be caused. Dermatitis, accompanied by fever and swelling. Particularly, in the spring, sebum secretion becomes vigorous. When sebum is mixed with contaminants in the yellow dust, fine dust, and bacteria, skin troubles such as acne are likely to occur or become serious.

Tobacco smoke harms skin health by irradiating various chemicals contained in it. Tobacco smoke causes skin to dry, rusts due to lack of oxygen and nutrients, and promotes skin aging. Therefore, it is important to prevent damage to the skin caused by harmful substances and ultraviolet rays of the external environment and to recover damaged skin.

Accordingly, it is an object of the present invention to provide a skin protection cosmetic composition that effectively protects skin damage caused by external harmful environment and helps to recover damaged skin.

The present inventors have found that the cosmetic composition containing the Moringa seed extract and Pombleline has an excellent effect on skin protection such as effectively protecting skin damage caused by external harmful environment and helping to recover damaged skin. The invention was completed.

The cosmetic composition according to the present invention has an excellent skin protection effect against heavy metals and tobacco smoke, harmful substances by forming a film when applying the skin and efficacy of Moringa seed extract having the ability to cleanse the skin damaged from contaminants and ultraviolet rays. Pombeline's ability to block contact with the skin and restore damaged skin due to irritation not only protects the skin from external harmful factors such as yellow dust, smog, tobacco smoke, ultraviolet rays, etc. There is an effect that can help.

The present invention provides a cosmetic composition containing Moringa seed extract and Pomblein. The Moringa seed extract is characterized in that the solvent is extracted with a polar solvent selected from water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, most preferably, ethanol is added.

In addition, the composition is characterized in that it has the effect of protecting skin cells from heavy metals.

In addition, the composition protects the skin from tobacco smoke, as well as having a skin purifying action, characterized in that to reduce damage due to ultraviolet rays.

In addition, the composition is characterized in that it has the effect of protecting the skin from external irritants.

In addition, the composition is characterized by an improvement in skin disease due to long-term external stimulation.

Moringa (Moringa oleifera = pterygosperma) used in the present invention is also called Naviday (from Neverbe: never die), the extract of the seed is used. Moringa grows in India and the rainforests, and also in Africa and Asia. Its height is 5 to 10 meters, white flowers bloom, and seeds are like bean pods and have 7 to 20 fruits in one pod. Moringa has been widely used in Africa and Asia, with fruit being edible and flowers and leaves as medicine. The finely crushed fruit is used to cleanse contaminated river water. Oil has been used in ancient civilizations for cosmetics, medicines and ritual ointments.

Pombulin used in the present invention is a fluorinated polymer used for the first time in cosmetics with a material also called polyperfluoromethylisopropyl ether or perfluoropolyethers. Pombulin is an unscented, colorless, matte, clear liquid polymer with the following structure:

Pomblin contains a large amount of fluorine with oxygen atoms as a bridge, and when applied to the skin, it forms a film, giving it a velvety feel. In addition, it has excellent chemical and thermal stability, is very stable in solvents and prevents the passage of foreign substances, but allows the passage of gases such as oxygen and carbon dioxide.

Moringa seed extract used in the present invention can be prepared as follows.

The Moringa seeds are washed thoroughly with water, dried in the shade, and then the dried Moringa seeds are placed in an extraction container and extracted for a period of time at an appropriate temperature in an appropriate amount of extraction solvent. The extract can be filtered and concentrated using a vacuum rotary evaporator or the like.

As the extraction solvent, a polar solvent selected from water (purified water), a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof may be used, and preferably ethanol is used.

The amount of the extraction solvent is 2 to 10 times the dry weight of Moringa seed. The extraction method may be an extraction method such as a bath extraction, reflux cooling extraction, ultrasonic extraction, etc., preferably may be extracted 1 to 5 times as an extraction method of the bath extraction.

The extraction temperature is 30 ~ 70 ℃, more preferably 40 ~ 60 ℃, most preferably maintained at about 50 ℃ is most effective in preventing rot, discoloration and odor.

The extraction time is 5 to 20 hours, preferably 10 hours.

After the moringa seed extract is obtained as described above, the solids may be removed using a filter paper, the suspension may be centrifuged, and the supernatant may be filtered under reduced pressure.

The filtered extract may be concentrated under reduced pressure at 20 ~ 100 ℃, preferably 50 ~ 70 ℃ with a vacuum rotary concentrator.

Moringa seed extract according to the present invention has the effect of protecting fibroblasts from heavy metals, protects the skin from tobacco smoke and has a skin cleansing action as well as reduces damage due to ultraviolet rays.

In the present invention, the Moringa seed extract and Pombulin are preferably used in an amount of 0.1 to 30.0% by weight, preferably 0.1 to 10.0% by weight, and when the amount of each used is less than 0.1% by weight, the effect of addition is not expressed. There is a weak or weak disadvantage, and when the content exceeds 30.0% by weight, the synergistic effect of addition is weak and not economical.

Cosmetics prepared from a cosmetic composition containing Moringa seed extract and Pombleline according to the present invention can be prepared in the form of general emulsion formulations and solubilized formulations. Cosmetics of the emulsified formulations include nutrient cosmetics, creams, essences, etc., and cosmetics of the solubilized formulations are flexible cosmetics.

In addition, the cosmetic composition containing the Moringa seed extract and pombulin of the present invention contains a dermatologically acceptable medium or base in addition to cosmetics in the form of adjuvants that can be applied topically or systemically, which is commonly used in the field of dermatology. Can be prepared.

Suitable cosmetic formulations include, for example, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionics (liposomes), nonionics obtained by dispersing an oil phase in a solution, gel, solid or pasty anhydrous product, aqueous phase. It may be provided in the form of a vesicle dispersant, in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. It may also be prepared in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

In addition to the Moringa seed extract, the cosmetic composition of the present invention contains fatty substances, organic solvents, solubilizers, thickening and gelling agents, softeners, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants. Commonly used in water, ionic or nonionic emulsifiers, fillers, metal ion sequestrants and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or cosmetics It may contain adjuvants conventionally used in the cosmetic or dermatological fields such as any other ingredients used. In addition, the above components may be introduced in an amount generally used in the field of dermatology.

Products to which the cosmetic composition of the present invention can be added include, for example, cosmetics such as astringent longevity, softening longevity, nourishing longevity, various creams, essences, packs, foundations, and the like, cleansing agents, soaps, treatments, Essence and the like.

Specific formulations of the cosmetic composition of the present invention include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, Formulations such as soaps, shampoos, cleansing foams, cleansing lotions, cleansing creams, body lotions, body cleansers, emulsions, press powders, loose powders, eye shadows and the like.

The following Examples and Experimental Examples illustrate the present invention more specifically, but the content of the present invention is not limited to the examples.

Production Example  One : Moringa  Preparation of Seed Extract

Moringa seeds 100g finely crushed in a crusher and immersed in 200ml of 100% ethanol and heated for 10 hours in a 50 ℃ water bath. The obtained extract was cooled to room temperature and filtered through a filter paper to give a filtrate. Ethanol was evaporated from the filtrate using nitrogen, concentrated, and then dissolved in 10% ethanol to prepare an extract.

Experimental Example  1: Cell protection from heavy metals

CCD986sk, a human fibroblast, was inoculated into a 12 well plate and incubated in a 37 ° C., 5% CO ₂ incubator for 24 hours. A fresh medium containing 75 uM of mercury and 100 uM of cadmium was added and the Moringa seed extract prepared in Preparation Example 1 was added to each well at a concentration of 0, 0.03, 0.1 and 0.3%, respectively, followed by 37 ° C., 5% CO After 72 hours of incubation in ₂ incubators, the protein was quantified according to the Bradford method, and the results are shown in Table 1.

density Protein amount Control 167 0% 7 0.03% 26 0.1% 34 0.3% 49

As can be seen from Table 1, it was found that there is an effect of inhibiting the death of fibroblasts on heavy metals (mercury, cadmium) depending on the concentration of Moringa fruit extract.

Experimental Example  2: Skin protection against cigarette smoke

Human skin was extracted at 2mg / cm ² , divided into two groups, group A was not applied, and group B was applied 3% Moringa seed extract. Each group was further divided into two groups, group I, clean air and group II, for 48 hours at 37 ° C. The degree of stress of the epidermal layer for each sample was confirmed through the immunostaining method, and the results are shown in Table 2.

Immunostaining amount of epidermis (degree of damage) A-Ⅰ 0 A-Ⅱ 22 B-Ⅰ 10 B-Ⅱ 2

Through Table 2 it was confirmed that the Moringa seed extract has the effect of preventing damage to the skin from tobacco smoke. In other words, the damage to tobacco smoke was 22 when no treatment was performed, whereas the damage was reduced to about 1/10 when Moringa seed extract was applied.

Experimental Example  3: inhibiting apoptosis due to ultraviolet rays

Moringa seed extract inhibited the generation of reactive oxygen species and the production of intracellular signaling molecules by ultraviolet light to determine whether the effect of inhibiting the death of skin cells by ultraviolet light. To this end, human keratinocytes were treated with Moringa seed extract, and then irradiated with ultraviolet B at 100 J / m 2 to confirm cell viability. That is, HaCaT cells, which are human keratinocyte lines, were divided into 6-well plates at a concentration of 3 × 10 5 cells / well. After 12 hours of serum starvation, the moringa seed extract was pretreated with 0.01, 0.03, and 0.1% for 30 minutes and UV B was irradiated at 100J / m2. The survival rate of the cells was measured 24 hours after ultraviolet irradiation, and the results are shown in Table 3.

density Cell survival rate (%) Control 100 UV irradiation + 0.01% extract 21 ± 2 UV irradiation + extract 0.03% 35 ± 2 UV irradiation + extract 0.1% 69 ± 1

Example  And Comparative example  1 to 2

A composition containing Moringa seed extract and Pombulin (Example), a composition containing only Moringa fruit extract (Comparative Example 1), and a composition containing nothing (Comparative Example 2) were prepared in the following compositions.

ingredient Example Comparative Example 1 Comparative Example 2 Content (% by weight) Content (% by weight) Content (% by weight) Moringa seed extract (Manufacturing Example 1) 2.0 2.0 - Pomblin 2.0 - - A Cetostearyl alcohol 2.0 2.0 2.0 Glyceryl Stearate 1.5 1.5 1.5 Mikey-Crystalline 0.7 0.7 0.7 Squalane 5.0 5.0 5.0 Liquid paraffin 3.0 3.0 3.0 Trioctanoine 5.0 5.0 5.0 Polysorbate 1.2 1.2 1.2 Sorbitan stearate 0.5 0.5 0.5 Tocopherol Acetate 0.2 0.2 0.2 Micromethicone 3.0 3.0 3.0 BHT 0.05 0.05 0.05 B glycerin 4.0 4.0 4.0 1,3-butylene glycol 2.0 2.0 2.0 EDTA-2Na 0.05 0.05 0.05 Purified water To 100 To 100 To 100 Incense, preservative Quantity Quantity Quantity

Experimental Example  4: skin cleansing effect

It was intended to confirm the contaminant purification effect in the human skin for the formulation of Example, Comparative Example 1 and Comparative Example 2 prepared in the composition of Table 4. The subjects were 10 subjects, and the test site was marked on the upper arm and 5% coal water (contaminant) was applied after each application of the formulation of Example, Comparative Example 1 and Comparative Example 2, respectively. water) was applied. Wipe the test site and measure the residual coal particles using skin video microscopy and the results are shown in Table 5.

sample coal particle reduction rate (%) Example 52 ± 2 Comparative Example 1 43 ± 1 Comparative Example 2 3 ± 1

As can be seen from Table 5, in Example and Comparative Example 1, the reduction rate of the contaminants was clearly seen, and in the case of Example, it was confirmed that the effect was superior to Comparative Example 1.

Experimental Example  5: skin irritation relief

Using the products of Examples, Comparative Example 1 and Comparative Example 2 prepared in Table 4, 80 subjects were tested for skin irritation for heavy metals. Each subject was divided into four groups, and the heavy metal powder was applied to the skin and applied twice a day without coating, Example, Comparative Example 1 and Comparative Example 2 for 4 weeks, and the results are shown in Table 6.

Number of people Control Example Comparative Example 1 Comparative Example 2 +++ 15 0 0 14 ++ 3 0 0 4 + 2 One 4 2 ± 0 One 5 0 - 0 18 11 0

※ Criteria

 +++: Strong trouble, ++: Weak trouble, +: Weak trouble, ±: Normal,-: Negative

As can be seen from Table 6, it can be seen that in Example and Comparative Example 1 to reduce the stimulation.

Experimental Example  6: Relieve skin diseases by stimulation

Using the products of Example, Comparative Example 1 and Comparative Example 2 prepared in Table 4, 80 patients with chronic non-allergic skin diseases were tested for skin disease relief. Each subject was divided into four groups, and applied to the skin disease site twice a day without coating, Example, Comparative Example 1, and Comparative Example 2 for 6 weeks, and visual evaluation was performed by a dermatologist. The results are shown in Table 7.

Number of people Control Example Comparative Example 1 Comparative Example 2 worse 5 0 0 3 No change 13 2 4 14 Slightly better 2 2 4 3 Improvement 0 6 5 0 Very good 0 10 7 0

As can be seen from Table 7, it was confirmed that the effect on skin diseases caused by stimulation in Example and Comparative Example 1.

Formulation example  1: flexible lotion

Formulation examples of the flexible lotion containing Moringa seed extract and Pombulin was prepared as shown in Table 8.

Raw material Content (% by weight) Moringa Seed Extract 1.00 Pomblin 1.00 1,3-butylene glycol 1.00 Disodium ID 0.05 Allantoin 0.10 Dipotassium glycylizate 0.05 Citrix Acid 0.01 Sodium citrate 0.02 Glyceres-26 1.00 Arbutin 2.00 Hydrogenated Castor Oil 1.00 ethanol 30.00 Preservative a very small amount coloring agent a very small amount Flavor a very small amount Purified water Remaining amount

Formulation example  2: nutrition cream

A formulation example of a nourishing cream containing Moringa seed extract and Pombleline was prepared as shown in Table 9 below.

Raw material Content (% by weight) Moringa Fruit Extract 1.0 Pomblin 1.0 1,3-butylene glycol 7.0 glycerin 1.0 D-panthenol 0.1 Plant extracts 3.2 Magnesium Aluminum Silicate 0.3 PEG-40 Stearate 1.2 Stearic acid 2.0 Polysorbate 60 1.5 Lipophilic glyceryl stearate 2.0 Sorbitan sesquioleate 1.5 Cetearyl Alcohol 3.0 Mineral oil 4.0 Squalane 3.8 Carlylic / Capric Triglycerides 2.8 vegetable oil 1.8 Dimethicone 0.4 Dipotassium glycylizate a very small amount Allantoin a very small amount Sodium hyaluronate a very small amount Tocopheryl Acetate Quantity Triethanolamine Quantity Preservative Quantity Flavor Quantity Purified water Remaining amount

Claims (5)

A cosmetic composition for skin protection containing Moringa seed extract and Pombulin. The cosmetic composition according to claim 1, wherein the Moringa seed extract and Pombleline are contained in an amount of 0.1 to 30.0 wt%, respectively. The cosmetic composition according to claim 1, wherein the composition containing Moringa seed extract and pombulin protects the skin from external harmful substances such as heavy metals, tobacco smoke, and ultraviolet rays. The cosmetic composition according to claim 1, wherein the Moringa seed extract is extracted by adding a polar solvent selected from water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof. The composition according to any one of claims 1 to 4, wherein the composition is a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nourishing lotion, a massage cream, a nourishing cream, a moisturizing cream, a hand cream, an essence , Nutrition essence, pack, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, latex, press powder, loose powder and eye shadow Cosmetic composition.