KR20090040517A - The components of cosmetics with the liposome including botanical extract which is effective for anti-acne and the method of manufacturing the components - Google Patents

Abstract

A cosmetic composition containing liposome of plant extract effective for acne prevention is provided to stably maintain extract without the loss of activity and to improve an skin care effect due to excellent skin penetration. A cosmetic composition comprises Terminaliae fructus extract or Alpiniae officinari Rhizoma extract stabilized by using liposome. The cosmetic composition comprises lecithin of 1.0-10.0%, ceramide of 0.1-2.0%, co-emulsifier of 0.1-0.8%, plant extract of 1.0-20.0% including Terminaliae fructus extract or Alpiniae officinari Rhizoma extract, antioxidant of 0.1-5.0%, solvent of 1.0-40.0% and liposome of emulsification stabilizer aid of 1.0-20.0%. The co-emulsifier is Tween 20, Tween 40, Tween 60 or Tween 80.

Description

The composition of cosmetics with the liposome including botanical extract which is effective for anti-acne and the method of manufacturing the components.

The present invention relates to a stabilization technology using liposomes of plant extracts effective in inhibiting acne, and a cosmetic composition containing the same and a method for producing the same.

In recent years, interest in functional cosmetics containing a specific bioactive substance for the purpose of acne suppression, etc. has been increasing and many studies have been conducted. The present invention also relates to such functional cosmetics, the plant extracts blended in the cosmetic composition of the present invention suppresses the activity of acne bacteria caused by various causes to exhibit the acne suppression function of the skin.

In order to apply the acne suppression function of the plant extracts to cosmetics has been proposed cosmetics added to the plant extracts cosmetics. However, conventional cosmetics have a problem in that the simple emulsification type products prepared by simply adding a plant extract to the cosmetic composition have a low penetrating power in the body to obtain the efficacy of the extract.

In order to solve this problem, liposomes that can be delivered stably without destroying the bioactive components are used.

However, in the past, liposomes with ceramides and cholesterol, which are cellular interstitial substances of the stratum corneum, or liposomes with lecithin, have limited stability.

Under these circumstances, the present inventors have studied to provide a composition of a plant extract-containing cosmetic composition which does not have the above-mentioned problems and has excellent skin penetration ability and can be stably preserved without loss of activity. As a result, the plant extract is converted into propylene glycol or butylene glycol. The present invention has been accomplished by discovering that the above object can be achieved by dissolving and liposomes to add it to the cosmetic.

That is, an object of the present invention is 1.0-10.0% lecithin of the total composition weight, 0.1-2.0% ceramide of the total composition weight, 0.1-0.8% coemulsifier of the total composition weight, 0.1-5.0% of the total weight of the composition Tocopheryl acetate, consisting of 1.0-40.0% propylene glycol of the total weight of the composition and 1.0-20.0% of the plant extract of the total weight of the composition, more specifically one or two extracts selected from Gaza extract, high-volume extract It is to provide a plant extract-containing cosmetic composition characterized in that it contains liposomes.

Still another object of the present invention is to prepare a cosmetic composition in which plant extract-containing liposomes are evenly dispersed by passing a mixture containing purified water, lecithin, ceramide, co-emulsifier, propylene glycol, and plant extract through a High Pressure Homogenizer. To provide.

Hereinafter, the present invention will be described in more detail.

Since the cosmetic composition provided according to the present invention contains liposome-ized plant extracts, it is very excellent in the transdermal absorption of plant extracts and can be stably preserved without losing the activity of the plant extracts.

In the present invention, a substance for forming a liposome containing a plant extract by contacting the plant extract to be liposomed is used with lecithin, and is used in an amount of 1.0% -10.0% based on the total weight of the composition.

In the present invention, the ceramide used to stabilize the liposomes and increase the liposome content of the water-soluble component is used in an amount of 0.1-2.0% based on the total weight of the composition.

Co-emulsifier for stabilizing liposomes in the present invention is one or a mixture of two or more selected from Tween 20, Tween 40, Tween 60 and Tween 80, and is used in an amount of 0.1-0.8% based on the total weight of the composition.

In the present invention, the antioxidant is used as one or two or more mixtures selected from tocopherol derivatives including tocopheryl acetate, and is used in an amount of 0.1-5.0% based on the total weight of the composition.

In the present invention, propylene glycol or butylene glycol is used to increase the solubility of the plant extract and is used in an amount of 1.0-40.0% based on the total weight of the composition.

The cosmetic composition of the present invention may contain an emulsification stabilizer to stabilize the plant extract, for example, glycerin may be used in an amount of 1.0-20.0% based on the total weight.

According to the method of the present invention, first, the lecithin and ceramide are dissolved in propylene glycol at 40-80 degrees, and then homogenized by adding tocopheryl acetate to make a lecithin solution, and then dissolving the plant extract with propylene glycol to make a plant extract solution. The plant extract solution is slowly added to the lecithin solution, homogenized with a homomixer, and then slowly added to the aqueous solution containing the co-emulsifier to obtain an emulsion. The obtained emulsion is passed through a high pressure homogenizer to obtain an emulsion in which the plant extract-containing liposome is evenly dispersed.

By the method of the present invention as described above, the plant extract that has been used in the conventional cosmetics is more stable and can be sufficiently exhibited the acne suppression function of the plant extract by blending the cosmetics without loss of activity and improving the permeability when applied to the skin. It has become possible to provide cosmetics of the liposome type.

[Centrifuge Stability Test]

In order to determine the centrifugation stability of the products prepared according to the following examples and comparative examples, each product was prepared by 500g, and each dose was appropriately taken and centrifuged at 4000 RPM for 10 minutes, at 8000 RPM for 10 minutes, and at 12000 RPM for 10 minutes. The results obtained are shown in the table.

Table 1. Centrifuge Stability Test Results

As can be seen from the results of the centrifugation stability test of the table, Examples 1 and 2 containing the cosmetic composition stabilized plant extracts using liposome technique in Comparative Examples 1 and 2 containing the plant extracts by a general emulsification technique. It was confirmed that there is no problem in the centrifugation stability in comparison.

Hereinafter, the present invention will be described in more detail with reference to the following Examples, but the present invention is not limited to these Examples.

Table 2. Example 1 and Comparative Example 1

Manufacturing method

Example 1 Raw materials 1,2,11,12 and 13 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 3 is dissolved in the raw material 4 to be referred to as a Gaza extract solution. The raw materials 7 and 8 are dissolved in the raw material 9 at 40-80 degrees, cooled to 25-30 degrees, and then the raw material 10 is added and homogenized to be called a lecithin solution. The Gaza extract solution and the lecithin solution is mixed and homogenized at 25-30 degrees to be called a liposome solution. The aqueous phase and the liposome solution are slowly mixed at 25-30 ° C., and then passed through a high pressure homogenizer to obtain an emulsion in which Gaza extract-containing liposomes are uniformly dispersed, and then aged for 2-7 days.

Comparative Example 1: The raw materials 1,11 and 12 were mixed and homogenized at 70-80 degrees to be called an aqueous phase. Mix and homogenize raw material 3 in the water phase at 70-80 ° C. Add 5 and 6 raw materials, and allow it to mature for 2-7 days.

Table 3. Example 2 and Comparative Example 2

Manufacturing method

Example 2 Raw materials 1,2,11,12 and 13 were mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 3 is dissolved in the raw material 4 to be referred to as a high quantity river extract solution. The raw materials 7 and 8 are dissolved in the raw material 9 at 40-80 degrees, cooled to 25-30 degrees, and then the raw material 10 is added and homogenized to be called a lecithin solution. The high amount river extract solution and the lecithin solution is mixed at 25-30 degrees and homogenized to be called liposome solution. The aqueous phase and the liposome solution are slowly mixed at 25-30 degrees, and then passed through a high pressure homogenizer to obtain an emulsion in which a high amount of river extract-containing liposome is uniformly dispersed, and then aged for 2-7 days.

Comparative Example 2: The raw materials 1,11 and 12 were mixed and homogenized at 70-80 degrees to be called an aqueous phase. Mix and homogenize raw material 3 in the water phase at 70-80 ° C. Add 5 and 6 raw materials, and allow it to mature for 2-7 days.

Using the raw material prepared in the above Example was prepared in the same manner as in the formulation example below.

Prescription Example 1.

Prescription examples of skin lotions in cosmetics containing plant extract-containing liposomes are as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 4. Prescription Examples of Skin Lotion According to the Present Invention

Manufacturing method

Formulation Example 1: Raw material 2,3,4,8 was added to raw material 11 in order, and then dissolved by stirring. Then, raw material 5 was heated to 60 ° C. to dissolve, and then raw material 10 was added and stirred to raw material 11. Input. Finally, the raw materials 1,6,7,9 are added and sufficiently stirred, and then aged through a high pressure homogenizer.

Comparative Example 1: Raw material 2,3,4,8 was added to raw material 11 in order, followed by stirring to dissolve it. Then, raw material 5 was heated and dissolved at about 60 ° C., and then raw material 10 was added and stirred to prepare raw material 11 Put it in. Finally, the raw materials 6, 7, and 9 are added and sufficiently stirred, and then aged through a high pressure homogenizer.

Prescription Example 2.

Prescription examples of nutritional lotion in cosmetics containing plant extract-containing liposomes are as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 5. Examples of prescription of nutrition lotion according to the present invention

Manufacturing method

Formulation Example 2: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added at a constant temperature to homogenize and then again returned to the high pressure homogenizer. Pass it through. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature. Comparative Formulation Example 2 The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. . Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 3

Prescription examples of nutritional cream in cosmetics containing plant extract-containing liposomes are as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 6. Example of prescription of nutrition cream according to the present invention

Manufacturing method

Formulation Example 3: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added at a constant temperature to homogenize and then again returned to the high pressure homogenizer. Pass it through. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 3 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. . Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 4.

A prescription example of a massage cream in cosmetics containing plant extract-containing liposomes is as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 7. Prescription examples of massage cream according to the present invention

Manufacturing method

Formulation Example 4: The raw materials 8,9,10,11,13,16 are heated to 80-85 ° C with mixing and stirring, and then put into the manufacturing part, and then the emulsifier is activated and raw materials 2,3,4,5,6, 7,12 is heated to between 80-85 degrees and then emulsified. After emulsification, cool down to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, and cool raw material 1 to 35 degrees. After cooling to 25 degrees, it is aged.

Comparative Formulation Example 4: The raw materials 8,9,10,11,13,16 were mixed and stirred to be heated to 80-85 ° C and introduced into the manufacturing unit, followed by the operation of an emulsifier. Heat 7,7,12 to 80-85 ° C and add to emulsify. After emulsification, cool to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, cool to 25 degrees, and mature.

Prescription Example 5.

Prescription examples of nutritional essences in cosmetics containing plant extract-containing liposomes are as follows. Here, the plant extract-containing liposomes are those of Example 1.

Table 8. Prescription Examples of Nutritional Essences According to the Present Invention

Manufacturing method

Formulation Example 5: Raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added at a constant temperature to homogenize and then again returned to the high pressure homogenizer. Pass it through. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 5: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. . Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Figure 1 shows the bactericidal effect of Gaza extract against acne bacteria.

2 shows the bactericidal effect on acne bacteria of high-volume river extracts.

Claims (4)

A cosmetic composition in which one or two kinds of mixtures selected from Gaza extracts and high amount river extracts are stabilized using liposomes. A cosmetic composition containing liposomes of lecithin, ceramides, co-emulsifiers, plant extracts, antioxidants, solvents, and emulsion stabilizers, The plant extract is a mixture of one or two species selected from Gaza extract and high-volume extract, contained in an amount of 1.0-20.0% based on the total weight of the composition, Said lecithin is contained in an amount of 1.0-10.0% based on the total weight of the composition, Said ceramide is contained in an amount of 0.1-2.0% based on the total weight of the composition, The co-emulsifier is one or a mixture of two or more selected from Tween 20, Tween 40, Tween 60 and Tween 80, contained in an amount of 0.1-0.8% based on the total weight of the composition, The antioxidant is one or a mixture of two or more selected from tocopherol derivatives including tocopheryl acetate, contained in an amount of 0.1-5.0% based on the total weight of the composition, The solvent is one or a mixture of propylene glycol and butylene glycol, contained in an amount of 1.0-40.0% based on the total weight of the composition, The emulsifying stability adjuvant as glycerin is a plant extract-containing cosmetic composition, characterized in that it is contained in an amount of 1.0 to 20.0% based on the total weight of the composition. A method for preparing a cosmetic composition containing a plant extract-containing liposome in which plant extract-containing liposomes are evenly dispersed by passing a mixture containing purified water, lecithin, ceramide and plant extract through a high pressure homogenizer. The purified water is contained in an amount of 30.0-95.0% based on the total weight of the composition, Said lecithin is contained in an amount of 1.0-10.0% based on the total weight of the composition, Said ceramide is contained in an amount of 0.1-2.0% based on the total weight of the composition, The plant extract is a mixture of one or two species selected from Gaza extract and high-volume extract, contained in an amount of 1.0-20.0% based on the total weight of the composition. The cosmetic composition according to claim 1, wherein the cosmetic is formulated into a skin, a nutrient lotion, a nourishing cream, a massage cream or a nutrient essence.

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