KR100779819B1 - The stability technology of using the technology of the liposome including kinetin which is effective for anti-wrinkle and the components of cosmetics including the liposome and the method of manufacturing the components. - Google Patents

Abstract

According to the present invention, there is provided a cosmetic composition containing a kinetin-containing liposome effective for inhibiting skin aging, and a method for preparing the same, wherein the cosmetic composition of the present invention is 1.0-10.0% of the total composition weight, and 0.1-2.0% of the total weight of the composition. Ceramide, liposome consisting of 0.1-40.0% lactide of the total weight of the composition and 0.01-2.0% kinetin of the total weight of the composition, and propylene glycol as 0.1% -40.0% of the emulsifying stability aid of the total weight of the composition.

The cosmetic composition as described above can maintain the kinetin stably for a long time without loss of activity or alteration, and can exhibit sufficient skin cosmetic effects by kinetin because of its excellent penetration into the skin.

Lecithin, ceramide, kinetin, liposome, autoclave

Description

Stabilization technology using liposome technology of kinetin effective in inhibiting skin aging, and a cosmetic composition containing the same and a method for preparing the same {the stability technology of using the technology of the liposome including kinetin which is effective for anti-wrinkle and the components of cosmetics including the liposome and the method of manufacturing the components.}

Figure 1 shows antioxidants Idebenone, DL-α-tocopherol, Kinetin, Ubiquinone, L-ascorbic acid and Lipoic acid DL-α-lipoic- sunburn cell reduction due to ultraviolet rays of acid. (Reference: the Annual Meeting of the American Academy of Dermatology; February 6-11, 2004; Washington, DC (Acknowledgment: Pharma Cosmetix Research, Richmond, Va)).

Figure 2 shows antioxidants Idebenone, DL-α-tocopherol, Kinetin, Ubiquinone, L-ascorbic acid and Lipoic acid DL-α-lipoic- (Reference: the Annual Meeting of the American Academy of Dermatology; February 6-11, 2004; Washington, DC (Acknowledgment: Pharma Cosmetix Research, Richmond, Va)).

FIG. 3 shows antioxidants Idebenone, DL-α-tocopherol, Kinetin, Ubiquinone, L-ascorbic acid and Lipoic acid DL-α-lipoic- (Reference: the Annual Meeting of the American Academy of Dermatology; February 6-11, 2004; Washington, DC (Acknowledgment: Pharma) Cosmetix Research, Richmond, Va)).

The present invention relates to a stabilization technique using liposome technique of kinetin effective in inhibiting skin aging, and a cosmetic composition containing the same and a method for producing the same.

In recent years, interest in functional cosmetics containing specific bioactive substances for the purpose of delaying skin aging, etc. has been increasing and many studies have been conducted. The present invention also relates to such a functional cosmetic composition, which is a cosmetic composition containing kinetin having a function of protecting cells from free radicals in the skin and inhibiting skin aging. Kinetine blended in the cosmetic composition of the present invention suppresses the activity of free radicals caused by ultraviolet rays or various causes, thereby exhibiting a aging delay function of the skin.

In order to apply the antioxidant function of kinetin to cosmetics, cosmetics in which kinetin is added to cosmetics have been proposed. However, conventional cosmetics are simple emulsified type or gel type products prepared by simply adding kinetin to the cosmetic composition, and it is difficult to blend sufficient amounts of kinetin in the cosmetics, and also, kinetin contained in the cosmetics is precipitated during cosmetic preservation and applied. It has its limitations. For this reason, general substances are dissolved in purified water or oil, but kinetin is hardly dissolved in purified water or oil, and only a very small amount is dissolved in alcohol. Therefore, even when applied to cosmetics, separation or sedimentation may occur, and an appropriate amount may be applied. This is a difficult situation.

On the other hand, even in the case of liposome cosmetics, because the solubility of kinetin is low, precipitation occurs, so it is difficult to expect skin penetration, which is an advantage of liposomes.

Under these circumstances, the inventors of the present invention have studied intensively to provide a composition of a kinetin-containing cosmetic composition that does not have the above-mentioned problems and has excellent skin penetration and can be stably preserved without losing long-term activity. The present invention has been accomplished by discovering that the above object can be achieved by dissolving into liposomes and adding the same to cosmetics.

That is, an object of the present invention is 1.0-10.0% of the total composition weight of lecithin, 0.1-2.0% of the ceramide of the total weight of the composition, 0.1-40.0% of the total weight of the composition and 0.01-2.0% of the total weight of the composition It is to provide a kinepin-containing cosmetic composition characterized in that it contains a liposome consisting of kinetin.

Still another object of the present invention is to provide a method for preparing a cosmetic composition in which kinetin-containing liposomes are evenly dispersed by passing a mixture containing purified water, lecithin, ceramide, lactic acid and kinetin through a high pressure homogenizer. .

Hereinafter, the present invention will be described in more detail.

Since the cosmetic composition provided according to the present invention contains liposome-ized kinetin, it is very excellent in percutaneous absorption of kinetin and can be stably stored for a long time without losing the activity of kinetin.

In the present invention, as a substance for forming liposomes in contact with the kinetin to be liposomed, lecithin is used, and is used in an amount of 1.0% -10.0% based on the total weight of the composition.

The ceramides used in the present invention are used in amounts of 0.1-2.0% based on the total weight of the composition.

In the present invention, lactic acid or alpha hydroxy acid is used to increase the solubility of kinetin and is used in an amount of 0.1-40.0% based on the total weight of the composition.

The cosmetic composition of the present invention may contain an emulsification stabilizer to stabilize the kinetin, for example, a polymer such as propylene glycol, butylene glycol, glycerin, ziitol, natural polymer compound, 0.1-20.0% based on the total weight of the composition Can be used in amounts.

According to the method of the present invention, first, purified water, Tween 60 is stirred with a homomixer at 70-80 degrees, cooled, and maintained at about 40 degrees to make a homogeneous aqueous solution. Meanwhile, kinetin is dissolved in lactic acid at room temperature to make kinetin solution, and lecithin and ceramide are dissolved in propylene glycol at 40 ° C to make lecithin solution. It is slowly added to an aqueous solution to obtain an emulsion. The obtained emulsion is passed through a high pressure homogenizer to obtain an emulsion in which the kinetin-containing liposome is evenly dispersed.

Emulsion type capable of fully exhibiting the antioxidant function of kinetin by blending kinetin, which has been conventionally used in cosmetics, in cosmetics without loss of activity and improving permeability when applied to skin by the method of the present invention as described above. It was possible to provide cosmetics.

Hereinafter, the present invention will be described in more detail with reference to the following Examples, but the present invention is not limited to these Examples.

Table 1. Example 1 and Comparative Example 1

Manufacturing method

Example 1 Raw materials 1,2,3,12 and 13 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 4 is dissolved in the raw material 5 at 25 degrees and silicified to be referred to as a kinetin solution. The raw materials 9 and 10 are dissolved in the raw material 11 at 40 degrees and homogenized to be called a lecithin solution. The kinetin solution and the lecithin solution are mixed and homogenized at 30-40 degrees to be called a liposome solution. The aqueous phase and liposome solution are slowly mixed at 30-40 degrees, and then passed through a high pressure homogenizer to obtain a uniformly dispersed emulsion of kinetin-containing liposomes.

Comparative Example 1: The raw materials 1, 6, 12 and 13 are mixed at 70-80 degrees and homogenized to be called an aqueous phase. The raw material 4 is dissolved in the raw material 7 at 40 degrees and silicified to be referred to as a kinetin solution. The mixture is homogenized by mixing the kinetin solution at 40-45 ° C in the water phase, and aged for 2-7 days after adding the raw material 8.

Table 2. Example 2 and Comparative Example 2

Manufacturing method

Example 2 Raw materials 1,2,3,12 and 13 are mixed and homogenized at 70-80 degrees to be called water phase. The raw material 4 is dissolved in a raw material 5 at 25 degrees and silicified to be referred to as a kinetin solution. The raw materials 9 and 10 are dissolved in the raw material 11 at 40 degrees and homogenized to be called lecithin solution. The kinetin solution and the lecithin solution are mixed and homogenized at 30-40 degrees to be called a liposome solution. The aqueous phase and the liposome solution are slowly mixed at 30-40 degrees, and then passed through a high pressure homogenizer to obtain an emulsion in which the kinine-containing liposome is uniformly dispersed, and then aged for 2-7 days.

Comparative Example 2: Raw materials 1, 6, 12 and 13 were mixed at 70-80 degrees and homogenized to be called water phases. The raw material 4 is dissolved in the raw material 7 at 40 degrees and silicified to be referred to as a kinetin solution. The mixture is homogenized by mixing the kinetin solution at 40-45 ° C in the water phase, and aged for 2-7 days after adding the raw material 8.

Table 3. Example 3 and Comparative Example 3

Manufacturing method

Example 3 Raw materials 1,2,3,12 and 13 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 4 is dissolved in a raw material 5 at 25 degrees and silicified to be referred to as a kinetin solution. The raw materials 9 and 10 are dissolved in the raw material 11 at 40 degrees and homogenized to be called lecithin solution. The kinetin solution and the lecithin solution are mixed and homogenized at 30-40 degrees to be called a liposome solution. The aqueous phase and liposome solution are slowly mixed at 30-40 degrees, and then passed through a high pressure homogenizer to obtain a uniformly dispersed emulsion of kinetin-containing liposomes.

Comparative Example 3: The raw materials 1, 6, 12 and 13 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 4 is dissolved in the raw material 7 at 40 degrees and silicified to be referred to as a kinetin solution. The mixture is homogenized by mixing the kinetin solution at 40-45 ° C in the water phase, and aged for 2-7 days after adding the raw material 8.

Table 4. Example 4 and Comparative Example 4

Manufacturing method

Example 4 According to a conventional simple emulsification method, the raw materials 1, 6, 7 and 8 are mixed at 70-80 degrees, and the raw materials 5 are added and mixed well, and then the remaining raw materials 4 are mixed at 40-45 degrees. It is aged for 2-7 days.

Comparative Example 4: The raw material 2 is dissolved in the raw material 3 at 40-50 degrees to homogenize, and this is called a kinetin solution. The raw materials 1, 6, 7 and 8 are mixed at 70-80 degrees according to the conventional simple emulsification method, the raw materials 5 are mixed well, and the kinetin solution is mixed at 40-45 degrees and aged for 2-7 days. .

Table 5. Example 5 and Comparative Example 5

Manufacturing method

Example 5 Raw materials 1,2,3,10 and 11 are mixed and homogenized at 70-80 degrees to be called water phase. The raw material 4 is dissolved in the raw material 5 at 25 degrees and silicified to be referred to as a kinetin solution. Raw materials 7 and 8 are dissolved in raw material 9 at 40 degrees and homogenized to be called lecithin solution. The kinetin solution and the lecithin solution are mixed and homogenized at 30-40 degrees to be called a liposome solution. The aqueous phase and the liposome solution are slowly mixed at 30-40 degrees, and then passed through a high pressure homogenizer to obtain an emulsion in which kinetin-containing liposomes are uniformly dispersed, followed by aging for 2-7 days.

Comparative Example 5: The raw materials 1,2,3,10 and 11 are mixed and homogenized at 70-80 degrees to be called an aqueous phase. The raw material 4 is dissolved in the raw material 6 at 40 degrees and silicified to be referred to as a kinetin solution. Raw materials 7 and 8 are dissolved in raw material 9 at 40 degrees and homogenized to be called lecithin solution. The kinetin solution and the lecithin solution are mixed and homogenized at 30-40 degrees to be called a liposome solution. The aqueous phase and liposome solution are slowly mixed at 30-40 degrees, and then passed through a high pressure homogenizer to obtain a uniformly dispersed emulsion of kinetin-containing liposomes.

[Centrifuge Stability Test]

In order to determine the centrifugation stability of the products manufactured according to the above examples and comparative examples, 500g of each product was prepared and taken in an appropriate amount, followed by centrifugation at 10 minutes at 4000 RPM, 10 minutes at 8000 RPM, and 10 minutes at 12000 RPM. The results obtained are shown in the table.

Table 6. Centrifuge Stability Test Results

As can be seen from the results of the centrifugation stability test of the table, Examples 1, 2, 3 and 4 containing the cosmetic composition stabilized kinetin using liposome technique are Comparative Examples 1, containing kinetin by general emulsification technique. It was confirmed that there is no problem in the centrifugation stability as compared to 2, 3 and 4.

In addition, Example 5 using the lactic acid as the solvent of kinetin was confirmed that there is no problem in the centrifugation safety compared to Comparative Example 5 using ethyl alcohol as the solvent of kinetin.

[Cyancular Qualitative Test]

In order to examine the stability over time of the products manufactured according to the above examples and comparative examples, 500g of each product was prepared and placed in a transparent glass container and stored at room temperature (25 °), high temperature (40 °), and daylight. Shown in the table.

Table 7. Time-lapse test results

As can be seen from the results of chronological stability test of the table, Examples 1, 2, 3, and 4 containing the cosmetic composition stabilized kinetin using liposome technique are examples 1, 2 and 3 containing kinetin by general emulsification technique. It was confirmed that there is no problem in storage stability over time, compared to 3, and 4.

In addition, it was confirmed that Example 5 using lactac acid as the solvent of kinetin has no problems with the storage stability over time compared to Comparative Example 5 using ethyl alcohol as the solvent of kinetin.

Using the raw material prepared in the above Example was prepared in the same manner as in the formulation example below.

Prescription Example 1.

A prescription example of a lotion (skin lotion) in a cosmetic containing a kinine-containing liposome is as follows. Wherein the kinetin-containing liposomes are from Example 1.

Table 8. Prescription example of skin lotion (skin lotion) according to the present invention

Manufacturing method

Formulation Example 1: Raw material 2,3,4,8 was added to raw material 11 in order to dissolve it, and then the raw material 5 was heated to 60 ° C. to dissolve, followed by input and stirring raw material 10 to raw material 11. Input. Finally, the raw materials 1,6,7,9 are added and thoroughly stirred, and then aged through a high pressure homogenizer.

Comparative Example 1: Raw material 2,3,4,8 was added to raw material 11 in order, followed by stirring to dissolve it. Then, raw material 5 was heated to about 60 ° C. to dissolve, and then raw material 10 was added and stirred to prepare raw material 11 Put it in. Finally, the raw materials 6, 7, and 9 are added and sufficiently stirred, and then aged through a high pressure homogenizer.

Prescription Example 2.

Prescription examples of nutritional lotions in cosmetics containing kinetin-containing liposomes are as follows. Wherein the kinetin-containing liposomes are from Example 1.

Table 9. Prescription example of nutrition lotion according to the present invention

Manufacturing method

Formulation Example 2: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 2 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 3

Prescription example of nutrition cream among cosmetics containing kinetin-containing liposomes is as follows. Wherein the kinetin-containing liposomes are from Example 1.

Table 10. Prescription example of nutrition cream according to the present invention

Manufacturing method

Formulation Example 3: Raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Scream Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 3 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 4.

A prescription example of a massage cream among cosmetics containing kinetin-containing liposomes is as follows. Wherein the kinetin liposomes are from Example 1.

Table 11. Prescription examples of massage cream according to the present invention

Manufacturing method

Formulation Example 4: The raw materials 8,9,10,11,13,16 are heated to 80-85 degrees with mixed agitation and put into the manufacturing part, and then the emulsifier is activated and the raw materials 2,3,4,5,6, 7,12 is heated to between 80-85 degrees and then emulsified. After emulsification, cool down to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, and cool raw material 1 to 35 degrees. After cooling to 25 degrees, it is aged.

Comparative Formulation 4: The raw materials 8, 9, 10, 11, 13 and 16 were mixed and stirred to be heated to 80-85 degrees and introduced into the manufacturing unit, followed by the operation of an emulsifier, and the raw materials 2, 3, 4, 5, 6 Heat 7,7,12 to 80-85 ° C and add to emulsify. After emulsification, cool to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, cool to 25 degrees, and mature.

Prescription Example 5.

Prescription examples of nutritional essences in cosmetics containing kinetin-containing liposomes are as follows. Wherein the kinetin-containing liposomes are from Example 1.

Table 12. Prescription Examples of Nutritional Essences According to the Present Invention

Manufacturing method

Formulation Example 5: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation 5: The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature and passed again through a high pressure homogenizer. . Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Claims (4)

A cosmetic composition in which kinetin is stabilized using liposomes, The liposomes described above contain kinetin in an amount of 0.01-2.0% based on the total weight of the composition, Lecithin is contained in an amount of 1.0-10.0% based on the total weight of the composition, Ceramide is contained in an amount of 0.1-2.0% based on the total weight of the composition, Contains lactic acid in an amount of 0.1-40.0% based on the total weight of the composition, As the liposome eye aid, one or two or more mixtures selected from propylene glycol, butylene glycol, glycerin, xyitol, or a natural polymer compound are contained in an amount of 0.1-40.0% based on the total weight of the composition. A kinetin-containing cosmetic composition containing lecithin, ceramide, lactic acid, kinetin, and liposomes of an emulsifier The above kinetine is contained in an amount of 0.01-2.0% based on the total weight of the composition, Said lecithin is contained in an amount of 1.0-10.0% based on the total weight of the composition, Said ceramide is contained in an amount of 0.1-2.0% based on the total weight of the composition, The lactic acid is contained in an amount of 0.1-40.0% based on the total weight of the composition, The above emulsifying stability aids include kininetin, characterized in that it is contained in an amount of 0.1-40.0% based on the total weight of the composition as one or two or more mixtures selected from propylene glycol, butylene glycol, glycerin, gyritol or natural polymer compounds. Cosmetic composition. A method for producing a cosmetic composition containing kinetin-containing liposomes in which kinetin-containing liposomes are evenly dispersed by passing a mixture containing purified water, lecithin, ceramide, kinetin, lactic acid and ophthalmic aids through a High Pressure Homogenizer. The above mixture is Contains purified water in an amount of 50.0-95.0% based on the total weight of the composition, Lecithin is contained in an amount of 1.0-10.0% based on the total weight of the composition, Ceramide is contained in an amount of 0.1-2.0% based on the total weight of the composition, Contains kinetin in an amount of 0.01-2.0% based on the total weight of the composition, Contains lactic acid, a solvent of kinetin, in an amount of 0.1-40.0% based on the total weight of the composition, As the safety aid, one or two or more mixtures selected from propylene glycol, butylene glycol, glycerin, ziitol, or a natural polymer compound are contained in an amount of 0.1-40.0% based on the total weight of the composition. The cosmetic composition according to claim 1, wherein the cosmetic is formulated as a lotion (skin lotion), nutrition lotion, nutrition cream, massage cream or nutrition essence.

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