KR20090010671A

KR20090010671A - The stability technology of using the technology of nano spherical particles including perfluorodecalin & perfluorobutyl ether which are oxygen carriers and the components of cosmetics including the nano spherical particles and the method of manufacturing the components

Info

Publication number: KR20090010671A
Application number: KR1020070073979A
Authority: KR
Inventors: 김재용
Original assignee: 김재용
Priority date: 2007-07-24
Filing date: 2007-07-24
Publication date: 2009-01-30

Abstract

According to the present invention, there is provided a stabilization technique using a microsphere method of perfluorodecarine and perfluorobutyl ether, which are oxygen transfer materials, and a cosmetic composition containing the same, and a method for preparing the same , wherein the cosmetic composition of the present invention is a total composition. Microspheres consisting of 0.1-10.0% by weight of poloxamer 188, 0.1-60.0% of perfluorodecarin by weight of the total composition and 0.1-60.0% of perfluorobutyl ether by weight of the composition, of the total weight of the composition Glycerin as an emulsion stability aid of 0.1% -20.0% is contained.

The cosmetic composition as described above can maintain purple orodercane and purple orobutyl ether stably for a long period of time without loss of activity or alteration, and has excellent affinity with the skin, so purple ordecaline and purple orobutyl ether It can fully exhibit the skin beauty effect by.

Description

Stabilization technology using microspheres method of perfluorodecarine and perfluorobutyl ether of oxygen transfer material, and a cosmetic composition containing the same and a method for producing the same. {The stability technology of using the technology of nano spherical particles including perfluorodecalin & perfluorobutyl ether which are oxygen carriers and the components of cosmetics including the nano spherical particles and the method of manufacturing the components.}

Figure 1 shows the increase in the partial pressure of oxygen in the skin with increasing purple ordecaline (3.2, 4.8, 6, 8, 10%) (International Journal of Cosmetic Science, 18 137-150 (1996)).

Figure 2 compares the change in wrinkle depth of unapplied and applied products of purple orodecarin.

3 shows the solubility of perfluorobutyl ether in oxygen (ml / 100ml) at room temperature and 1 atmosphere.

4 shows the main part of the High Pressure Homogenizer.

The present invention relates to a stabilization technique using a microsphere method of perfluorodecarine and perfluorobutyl ether, which is an oxygen transfer material, and a cosmetic composition containing the same and a manufacturing method thereof .

In recent years, interest in functional cosmetics containing specific bioactive substances for the purpose of delaying skin aging, etc. has been increasing and many studies have been conducted. The present invention also relates to such a functional cosmetics is a cosmetic composition containing perfluorodecarin and perfluorobutyl ether having a function to increase the oxygen partial pressure of the skin . Purple aurodekarin and purple aobutyl ether blended in the cosmetic composition of the present invention is an oxygen carrier to increase the oxygen partial pressure of the skin lowered due to environmental factors such as ageing or smoking, thereby supplying oxygen to the skin. Aging delay function.

In order to apply the oxygen transport function of the purple orode carin and purple orobutyl ether to the cosmetics, cosmetics in which purple ordecarin or purple orobutyl ether is added to the cosmetics have been limited. However, conventional cosmetics are simple emulsified or gel type products prepared by simply adding purple orodecarine or purple orobutyl ether to the cosmetic composition. It is difficult to formulate, and has a drawback that there is a limit in application and separation in the preservation of perfluorodecarin or perfluorobutyl ether cosmetics contained in the cosmetic. The reason is generally the proportion of the cosmetic is 1.00 and out, but the proportion of decalin Oro perfluoroalkyl is 1.917, and the segregation or the precipitation occurs also haebomyeon observe the long-term stability to the proportion of purple Le oro-butyl ether is applied to more than 1.40 then the cosmetic It is difficult to apply the proper amount.

On the other hand, cosmetics of the drug delivery system (DD S method) recently used in pharmaceuticals have been proposed. In the case of liposome cosmetics, liposomes are required to be hydrophilic or lipophilic, so that appropriate liposomes are required for liposomes. There was a problem that must be selected.

Under such circumstances, the present inventors earnestly studied to provide a composition of perfluorodecarine and perfluorobutyl ether- containing cosmetics which do not have the above-mentioned problems and have excellent skin penetration and can be stably preserved without losing long-term activity. Results It has been found that the above object can be achieved by making microspheres of purple orodecarine and purple orobutyl ether added to cosmetics, and have completed the present invention.

That is, an object of the present invention is 0.1-10.0% of poloxamer 188 of the total composition weight, 0.1-60.0% of perfluorodecarinine of the total composition weight and 0.1-60.0% of perfluorobutyl ether of the total weight of the composition ( It is to provide a perfluorodecarine and perfluorobutyl ether- containing cosmetic composition, characterized in that it contains microspheres consisting of Perfluorobutyl ether) .

Still another object of the present invention is to pass a mixture containing purified water, poloxamer 188, perfluorodecarine and perfluorobutyl ether through a high pressure homogenizer to perfluorodecarine and perfluorobutyl. It is to provide a method for producing a cosmetic composition in which the ether- containing microspheres are evenly dispersed.

Hereinafter, the present invention will be described in more detail.

Since the cosmetic composition provided according to the present invention contains microencapsulated perfluorodecarine and perfluorobutyl ether, the percutaneous absorption of perfluorodecarine and perfluorobutyl ether is very excellent, and perfluorodecarin and It can be stably stored for a long time without losing the activity of perfluorobutyl ether .

Poloxamer 188 is used as a material for forming micelles containing perfluorodecarine and perfluorobutyl ether in contact with perfluorodecarine and perfluorobutyl ether to be encapsulated in the present invention. Used in amounts of 0.1% -10.0% by weight of the total.

The perfluorodecarin used in the present invention is used in an amount of 0.1-60.0% based on the total weight of the composition, and the perfluoropolybutyl ether is used in an amount of 0.1-60.0% based on the total weight of the composition.

The cosmetic composition of the present invention may contain an emulsification stabilizer to stabilize the perfluorodecarin and perfluorobutyl ether , and for example, polymers such as glycerin, and natural polymer compounds may be added in an amount of 0.1-to the total weight of the composition. It can be used in an amount of 20.0%.

According to the method of the present invention, first, purified water, poloxamer 188 is stirred with a homomixer, and the temperature is maintained at about 80 degrees to form a homogeneous aqueous solution. Meanwhile, a mixture of perfluorodecarin and perfluorobutyl ether is prepared and slowly added to the previously prepared aqueous solution to obtain an emulsion. The obtained emulsion is passed through a high pressure homogenizer to obtain an emulsion in which microspheres containing perfluorodecarin and perfluorobutyl ether are evenly dispersed.

According to the method of the present invention as described above, purple ordeoderine and purple orobutyl ether, which have been used in conventional medicines, are stabilized and blended into cosmetics without loss of activity, and improve permeability when applied to skin. It has become possible to provide an emulsion type cosmetic that can sufficiently exhibit the oxygen transport function possessed by decalin and perfluoroether .

Hereinafter, the present invention will be described in more detail with reference to the following Examples, but the present invention is not limited to these Examples.

Table 1. Example 1 and Comparative Example 1

Manufacturing method

Example 1: The raw materials 1,2,3,11 and 12 were homogenized at 80-90 degrees to be called an aqueous phase. After slowly mixing the aqueous phase and the raw materials 4,5,6 and 7 at 25-35 degrees, the mixture passes through a high pressure homogenizer to obtain purple aurodecarine and purple aurobutyl ether-containing microspheres. After obtaining a uniformly dispersed emulsion to stabilize it is aged for 2-7 days.

Comparative Example 1 The raw materials 1, 8, 9, 11 and 12 were mixed at 80-90 degrees according to the conventional simple emulsification method, and the raw materials 4, 5 and 10 were mixed at 25-35 degrees and mixed well. -Maturate for 7 days.

Table 2. Example 2 and Comparative Example 2

Manufacturing method

Example 2 Raw materials 1,2,3,11 and 12 are homogenized at 80-90 degrees to be called water phase. After slowly mixing the aqueous phase and the raw materials 4,5,6 and 7 at 25-35 degrees, the mixture passes through a high pressure homogenizer to obtain purple aurodecarine and purple aurobutyl ether-containing microspheres. After obtaining a uniformly dispersed emulsion to stabilize it is aged for 2-7 days.

Comparative Example 2 The raw materials 1, 8, 9, 11 and 12 were mixed at 80-90 degrees according to a conventional simple emulsification method, and the raw materials 4, 5 and 10 were added at 25-35 degrees and mixed well. -Maturate for 7 days.

Table 3. Example 3 and Comparative Example 3

Manufacturing method

Example 3: The raw materials 1,2,3,10 and 11 are homogenized at 80-90 degrees to be called an aqueous phase. After slowly mixing the aqueous phase and the raw materials 4, 5, and 6 at 25-35 degrees, passing through a High Pressure Homogenizer to obtain an emulsion in which perfluorobutyl ether-containing microspheres are uniformly dispersed. After stabilization, ripen for 2-7 days.

Comparative Example 3 The raw materials 1,7,8,10 and 11 were mixed at 80-90 degrees according to the conventional simple emulsification method, and the raw materials 4 and 9 were added at 25-35 degrees and mixed well. Aged daily.

Table 4. Example 4 and Comparative Example 4

Manufacturing method

Example 4 The raw materials 1, 6, 7 and 8 were mixed at 80-90 degrees according to a conventional simple emulsification method, and the raw materials 5 were added and mixed well, and then the remaining raw materials 4 were mixed at 25-35 degrees. It is aged for 2-7 days.

Comparative Example 4 The raw materials 1, 6, 7 and 8 were mixed at 80-90 degrees according to the conventional simple emulsification method and mixed well by adding the raw material 5, and then the remaining raw materials 2 and 3 at 25-35 degrees. Mix and mature for 2-7 days.

[Centrifuge Stability Test]

In order to determine the centrifugation stability of the products manufactured according to the above examples and comparative examples, 500g of each product was prepared and taken in an appropriate amount, followed by centrifugation at 10 minutes at 4000 RPM, 10 minutes at 8000 RPM, and 10 minutes at 12000 RPM. The results obtained are shown in the table.

Table 5. Centrifuge Stability Test Results

As can be seen from the results of the centrifugation stability test of the table, Examples 1, 2, 3, and 4 containing a cosmetic composition stabilized with fluorine compounds using microspheres are comparative examples containing fluorine compounds by general emulsification. It was confirmed that there is no problem in the centrifugation stability compared to 1,2,3 and 4.

Using the raw material prepared in the above Example was prepared in the same manner as in the formulation example below.

Prescription Example 1.

Prescription examples of skin lotions in cosmetics containing purple aurodecalin and purple aurobutyl ether microspheres are as follows. Here, purple ordecaline and purple orobutyl ether microspheres are those of Example 1.

Table 6. Prescription example of skin lotion according to the present invention

Manufacturing method

Formulation Example 1: Raw material 2,3,4,8 was added to raw material 11 in order to dissolve it, and then the raw material 5 was heated to 60 ° C. to dissolve, followed by input and stirring raw material 10 to raw material 11. Input. After inputting the raw material 1 and stirring it sufficiently, the raw material 6,7,9 is finally added and stirred sufficiently, and then passed through a high pressure homogenizer and aged.

Comparative Example 1: Raw material 2,3,4,8 was added to raw material 11 in order, followed by stirring to dissolve it. Then, raw material 5 was heated to about 60 ° C. to dissolve, and then raw material 10 was added and stirred to prepare raw material 11 Put it in. Finally, the raw materials 6, 7, and 9 are added and sufficiently stirred, and then aged through a high pressure homogenizer.

Prescription Example 2.

Prescription examples of nutritional lotions in cosmetics containing purple orode carin and purple orobutyl ether microspheres are as follows. Here, the perfluorodecarine and the perfluorobutyl ether microspheres are those of Example 1.

Table 7. Prescription example of nutrition lotion according to the present invention

Manufacturing method

Formulation Example 2: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 2: The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 3

Prescription examples of nutritional creams in cosmetics containing purple orodecarin and purple orobutyl ether microspheres are as follows. Here, purple ordecaline and purple orobutyl ether microspheres are those of Example 1.

Table 8. Prescription example of nutrition cream according to the present invention

Manufacturing method

Formulation Example 3: Raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 3 The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Prescription Example 4.

The prescription of the massage cream in cosmetics containing purple orodecarine and purple orobutyl ether microspheres is as follows. Here, purple ordecaline and purple orobutyl ether microspheres are those of Example 1.

Table 9. Prescription example of massage cream according to the present invention

Manufacturing method

Formulation Example 4: The raw materials 8,9,10,11,13,16 are heated to 80-85 ° C with mixing and stirring, and then put into the manufacturing part, and then the emulsifier is activated and raw materials 2,3,4,5,6, 7,12 is heated to between 80-85 degrees and then emulsified. After emulsification, cool to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, and feed raw material 1 when cooled to 25-35 degrees. After cooling to 25 degrees, it is aged.

Comparative Formulation Example 4: The raw materials 8,9,10,11,13,16 were mixed and stirred to be heated to 80-85 degrees and introduced into the manufacturing unit, followed by the operation of an emulsifier, and the raw materials 2,3,4,5, 6,7,12 is heated to between 80-85 degrees and emulsified. After emulsification, cool to 50 degrees while stirring using a stirrer, add raw material 14, cool to 45 degrees, add raw material 15, cool to 25 degrees, and mature.

Prescription Example 5.

Prescription examples of nutritional essences in cosmetics containing purple aurodecalin and purple aurobutyl ether microspheres are as follows. Here, the perfluorodecarine and the perfluorobutyl ether microspheres are those of Example 1.

Table 10. Prescription Examples of Nutritional Essences According to the Present Invention

Manufacturing method

Formulation Example 5: The raw materials 2,3,4,5 and 6 are homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 1,7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Let's do it. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Comparative Formulation Example 5: The raw materials 2,3,4,5 and 6 were homogenized at a constant temperature to be referred to as nonionic amphiphilic lipids. The nonionic amphiphilic lipid and the raw materials 7,8 and 14 are mixed and homogenized at a constant temperature and passed through a high pressure homogenizer, and then the raw material 9 is gradually added and homogenized at a constant temperature, and then passed through the high pressure homogenizer again. Then, the raw materials 10, 11, 12, 13 are added and dispersed to stabilize and mature.

Claims

Cosmetic composition which stabilized perfluorobutyl ether using microspheres.

A fluorine compound-containing cosmetic composition containing poloxamer 188, a fluorine compound, and microspheres of an emulsifying stability aid,

The above-mentioned fluorine compound is one or two mixtures selected from ethyl perfluorobutyl ether and methyl perfluorobutyl ether contained in an amount of 0.1-60.0% of the total weight of the composition, and 0.1-60.0% of the total weight of the composition. It is contained as a mixture of purple ordecarin in the amount of

The poloxamer 188 is contained in an amount of 0.1-10.0% with respect to the total weight of the composition, and the emulsifying stability aid is one or two or more mixtures selected from glycerin or a natural polymer compound, and is 0.1-% with respect to the total weight of the composition. A fluorine compound-containing cosmetic composition, characterized in that contained in an amount of 20.0%.

A mixture containing one or two selected from purified water, poloxamer 188, ethyl perfluorobutyl ether and methyl perfluorobutyl ether, and perfluorodecarine is passed through a high pressure homogenizer to obtain ethyl purple. A method for producing a cosmetic composition in which one or two selected from orobutyl ether and methyl perfluorobutyl ether and the perfluorodecarine-containing microspheres are evenly dispersed.

The cosmetic composition according to claim 1, wherein the cosmetic is formulated into a skin lotion, a nutrition lotion, a nutrition cream, a massage cream or a nutrition essence.