KR20090023365A - 다층 실크 단백질 필름 - Google Patents
다층 실크 단백질 필름 Download PDFInfo
- Publication number
- KR20090023365A KR20090023365A KR1020087029623A KR20087029623A KR20090023365A KR 20090023365 A KR20090023365 A KR 20090023365A KR 1020087029623 A KR1020087029623 A KR 1020087029623A KR 20087029623 A KR20087029623 A KR 20087029623A KR 20090023365 A KR20090023365 A KR 20090023365A
- Authority
- KR
- South Korea
- Prior art keywords
- silk
- film
- silk protein
- multilayer film
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 161
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 156
- 238000000034 method Methods 0.000 claims abstract description 33
- 239000000463 material Substances 0.000 claims abstract description 23
- 239000010410 layer Substances 0.000 claims description 56
- 229920001872 Spider silk Polymers 0.000 claims description 29
- 239000000126 substance Substances 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 18
- 238000005266 casting Methods 0.000 claims description 16
- 102000008186 Collagen Human genes 0.000 claims description 11
- 108010035532 Collagen Proteins 0.000 claims description 11
- 229920001436 collagen Polymers 0.000 claims description 11
- 239000002904 solvent Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000012460 protein solution Substances 0.000 claims description 10
- 108010014258 Elastin Proteins 0.000 claims description 9
- 241000238631 Hexapoda Species 0.000 claims description 9
- 102000016942 Elastin Human genes 0.000 claims description 8
- 102000011782 Keratins Human genes 0.000 claims description 8
- 108010076876 Keratins Proteins 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 8
- 229920002549 elastin Polymers 0.000 claims description 8
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 8
- 229920002518 Polyallylamine hydrochloride Polymers 0.000 claims description 7
- 239000004793 Polystyrene Substances 0.000 claims description 6
- 229920002223 polystyrene Polymers 0.000 claims description 6
- 239000002356 single layer Substances 0.000 claims description 5
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019253 formic acid Nutrition 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 150000002739 metals Chemical class 0.000 claims description 4
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 241000239223 Arachnida Species 0.000 claims description 3
- 241000500891 Insecta Species 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 2
- 238000004528 spin coating Methods 0.000 claims description 2
- 230000008016 vaporization Effects 0.000 claims description 2
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 abstract description 16
- 239000000047 product Substances 0.000 abstract description 3
- 239000010408 film Substances 0.000 description 171
- 235000018102 proteins Nutrition 0.000 description 128
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 26
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 24
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 15
- 229910000160 potassium phosphate Inorganic materials 0.000 description 12
- 235000011009 potassium phosphates Nutrition 0.000 description 12
- 239000003814 drug Substances 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 11
- 239000012528 membrane Substances 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- 210000003491 skin Anatomy 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- 101710191899 Actin-depolymerizing factor 3 Proteins 0.000 description 6
- 241000239290 Araneae Species 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- 150000001413 amino acids Chemical group 0.000 description 6
- 238000012377 drug delivery Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 238000001728 nano-filtration Methods 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 241000193935 Araneus diadematus Species 0.000 description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
- 241000255789 Bombyx mori Species 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 102000005936 beta-Galactosidase Human genes 0.000 description 4
- 108010005774 beta-Galactosidase Proteins 0.000 description 4
- 238000001142 circular dichroism spectrum Methods 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 229920000371 poly(diallyldimethylammonium chloride) polymer Polymers 0.000 description 4
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 4
- OPIFSICVWOWJMJ-AEOCFKNESA-N 5-bromo-4-chloro-3-indolyl beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=C(Br)C(Cl)=C12 OPIFSICVWOWJMJ-AEOCFKNESA-N 0.000 description 3
- 101150082901 ADF3 gene Proteins 0.000 description 3
- 101150003973 ADF4 gene Proteins 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 108010022355 Fibroins Proteins 0.000 description 3
- 241000237536 Mytilus edulis Species 0.000 description 3
- 241000238902 Nephila clavipes Species 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000002983 circular dichroism Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000001223 reverse osmosis Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 2
- 239000000592 Artificial Cell Substances 0.000 description 2
- 102100030981 Beta-alanine-activating enzyme Human genes 0.000 description 2
- 101150012469 CYS2 gene Proteins 0.000 description 2
- 102100025802 Cystin-1 Human genes 0.000 description 2
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 101000773364 Homo sapiens Beta-alanine-activating enzyme Proteins 0.000 description 2
- 101000855767 Homo sapiens Cystin-1 Proteins 0.000 description 2
- 101150044775 LYS1 gene Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 241000595629 Plodia interpunctella Species 0.000 description 2
- 101100222745 Schizosaccharomyces pombe (strain 972 / ATCC 24843) met17 gene Proteins 0.000 description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 239000001961 anticonvulsive agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- -1 for example Substances 0.000 description 2
- 238000007429 general method Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000020638 mussel Nutrition 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000004252 protein component Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910000077 silane Inorganic materials 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000009482 thermal adhesion granulation Methods 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 description 1
- 241001481380 Antheraea mylitta Species 0.000 description 1
- 241000238901 Araneidae Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241000167854 Bourreria succulenta Species 0.000 description 1
- 241001152449 Ceratopsyche slossonae Species 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 241001441916 Diadema Species 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 102100033167 Elastin Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000122098 Ephestia kuehniella Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 241000255896 Galleria mellonella Species 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 241000256023 Hyalophora cecropia Species 0.000 description 1
- 241000221931 Hypomyces rosellus Species 0.000 description 1
- 241001049902 Kuehniella Species 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 240000006240 Linum usitatissimum Species 0.000 description 1
- 235000004431 Linum usitatissimum Nutrition 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 206010027603 Migraine headaches Diseases 0.000 description 1
- 241000819714 Monema flavescens Species 0.000 description 1
- 241000237524 Mytilus Species 0.000 description 1
- 241001147138 Mytilus galloprovincialis Species 0.000 description 1
- 241000882864 Mytilus sp. Species 0.000 description 1
- 241000244206 Nematoda Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 241000321765 Quadrula aurea Species 0.000 description 1
- 241000219492 Quercus Species 0.000 description 1
- 101710137510 Saimiri transformation-associated protein Proteins 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- 241000789545 Trimeria grandifolia Species 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000004566 building material Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 239000000864 hyperglycemic agent Substances 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000002161 passivation Methods 0.000 description 1
- 238000005373 pervaporation Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 108010028203 spidroin 2 Proteins 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003585 thioureas Chemical class 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31725—Of polyamide
- Y10T428/3175—Next to addition polymer from unsaturated monomer[s]
- Y10T428/31754—Natural source-type polyamide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31725—Of polyamide
- Y10T428/31768—Natural source-type polyamide [e.g., casein, gelatin, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing & Machinery (AREA)
- Insects & Arthropods (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Laminated Bodies (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06113438.3 | 2006-05-03 | ||
| EP20060113438 EP1852470A1 (en) | 2006-05-03 | 2006-05-03 | Multilayer Silk Protein Films |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20090023365A true KR20090023365A (ko) | 2009-03-04 |
Family
ID=37025251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087029623A Withdrawn KR20090023365A (ko) | 2006-05-03 | 2007-04-13 | 다층 실크 단백질 필름 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090263430A1 (https=) |
| EP (2) | EP1852470A1 (https=) |
| JP (1) | JP2009535242A (https=) |
| KR (1) | KR20090023365A (https=) |
| CN (1) | CN101460570B (https=) |
| AU (1) | AU2007247539C1 (https=) |
| CA (1) | CA2650836C (https=) |
| RU (1) | RU2008146255A (https=) |
| WO (1) | WO2007128378A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200056400A (ko) * | 2017-09-26 | 2020-05-22 | 스파이버 테크놀러지스 에이비 | 표면 활성 거대분자의 구조화 |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1976868T3 (da) | 2005-12-30 | 2015-04-20 | Spiber Technologies Ab | Edderkoppesilke-proteiner og fremgangsmåde til fremstilling af edderkoppesilke-proteiner |
| CA2704768A1 (en) * | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer sensor and method of manufacturing the same |
| US9969134B2 (en) | 2006-11-03 | 2018-05-15 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| WO2008127403A2 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer optofluidic device and method of manufacturing the same |
| CA2690658C (en) * | 2007-06-20 | 2016-08-09 | Basf Se | Synthetic repetitive proteins, their production and use thereof |
| GB2461125A (en) * | 2008-06-25 | 2009-12-30 | Spintec Engineering Gmbh | A silk membrane for bone graft material |
| JP2011530491A (ja) | 2008-08-08 | 2011-12-22 | ビーエーエスエフ ソシエタス・ヨーロピア | バイオポリマーに基づいた活性物質含有連続繊維層、その使用、およびその生産のための方法 |
| GB2464348A (en) * | 2008-10-17 | 2010-04-21 | Spintec Engineering Gmbh | Applying a liquid protein onto a permeable surface, and silk mono-filament having specific properties |
| US9861725B2 (en) | 2009-05-28 | 2018-01-09 | Addbio Ab | Multilayer protein films, methods of making, and drug delivery devices and biomedical implants employing the films |
| US9217017B2 (en) | 2009-12-08 | 2015-12-22 | Amsilk Gmbh | Silk protein coatings |
| RU2443805C1 (ru) * | 2010-08-20 | 2012-02-27 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет технологии и дизайна" (СПГУТД) | Способ получения пленки на основе фиброина шелка для изготовления контактных линз |
| RU2624036C2 (ru) | 2010-10-27 | 2017-06-30 | Спибер Текнолоджиз Аб | Структуры слитого белка шелка пауков для связывания с органической мишенью |
| US20120236298A1 (en) * | 2011-03-15 | 2012-09-20 | Michael Josef Stuke | Tunable apparatus for performing sers |
| CA2833144C (en) * | 2011-04-14 | 2020-09-29 | The Regents Of The University Of California | Multilayer thin film drug delivery device and methods of making and using the same |
| US20140378661A1 (en) * | 2011-04-20 | 2014-12-25 | Trustees Of Tufts College | Molded regenerated silk geometries using temperature control and mechanical processing |
| US9956387B2 (en) * | 2011-07-08 | 2018-05-01 | Timothy Brown | Article of clothing for applying a pharmaceutical, a pharmaceutical delivery kit and method |
| US9377409B2 (en) | 2011-07-29 | 2016-06-28 | Hewlett-Packard Development Company, L.P. | Fabricating an apparatus for use in a sensing application |
| JP2015510818A (ja) | 2012-03-20 | 2015-04-13 | トラスティーズ オブ タフツ カレッジ | 薬物送達のための絹リザーバー |
| EP2844360B1 (en) | 2012-05-02 | 2018-12-19 | Spiber Technologies AB | Spider silk fusion protein structures without repetitive fragment for binding to an organic target |
| US9856308B2 (en) | 2012-05-02 | 2018-01-02 | Spiber Technologies Ab | Spider silk fusion protein structures incorporating immunoglobulin fragments as affinity ligands |
| JP5678283B2 (ja) | 2012-12-26 | 2015-02-25 | スパイバー株式会社 | クモ糸タンパク質フィルム及びその製造方法 |
| CN103341214B (zh) * | 2013-07-08 | 2014-12-31 | 苏州大学 | 一种丝素蛋白膜及其制备方法 |
| EP3102250B1 (en) * | 2014-02-04 | 2020-05-13 | AMSilk GmbH | Coated silk films, methods for the production thereof and uses thereof |
| CN104323927A (zh) * | 2014-11-06 | 2015-02-04 | 济南星河康泰贸易有限公司 | 贻贝粘蛋白在制备皮肤美容化妆品上的应用 |
| JP6693049B2 (ja) * | 2015-05-21 | 2020-05-13 | 日立化成株式会社 | ナノ薄膜転写シート及び転写方法 |
| JP6544040B2 (ja) * | 2015-05-21 | 2019-07-17 | 日立化成株式会社 | フィブロインナノ薄膜、ナノ薄膜シート及び転写方法 |
| CN105297440B (zh) * | 2015-11-11 | 2018-01-12 | 浙江理工大学 | 一种对蚕丝接枝改性的方法 |
| EP3207947A1 (en) * | 2016-02-17 | 2017-08-23 | Ruprecht-Karls-Universität Heidelberg | Bioactive compound delivery assembly |
| WO2018006037A1 (en) * | 2016-07-01 | 2018-01-04 | Trustees Of Tufts College | Innervated artificial skin |
| CN106188923A (zh) * | 2016-08-04 | 2016-12-07 | 叶剑 | 一种聚苯乙烯基复合装饰板及其制造方法 |
| JP2021080304A (ja) * | 2018-01-26 | 2021-05-27 | Ｓｐｉｂｅｒ株式会社 | タンパク質成形体用素材、タンパク質成形体、及びタンパク質成形体の製造方法 |
| JP6743939B2 (ja) * | 2019-05-09 | 2020-08-19 | 日立化成株式会社 | ナノ薄膜転写シート及び転写方法 |
| WO2021113054A2 (en) * | 2019-11-13 | 2021-06-10 | Rapp Robert James | Spider silk proteins - small particle process and products |
| CN113652033B (zh) * | 2021-08-22 | 2022-12-06 | 茂泰(福建)鞋材有限公司 | 一种贻贝足丝防滑橡胶鞋底的制备方法 |
| US20240002682A1 (en) * | 2022-07-01 | 2024-01-04 | Ayro, Inc. | Coating gradient property management for sustainable vehicles, systems, methods, and apparatus |
| CN116285719B (zh) * | 2022-09-09 | 2026-03-24 | 之江实验室 | 一种丝素蛋白塑封膜及其制备方法和应用 |
| AU2023355666A1 (en) | 2022-10-03 | 2025-04-03 | Xampla Limited | Alginate-starch films |
| CN116103933B (zh) * | 2023-02-21 | 2024-08-13 | 现代纺织技术创新中心(鉴湖实验室) | 一种高牢度双层组合丝素蛋白涂层织物的制备方法 |
| CN117445491A (zh) * | 2023-12-06 | 2024-01-26 | 江西丝科生物科技有限公司 | 一种蛋白膜的复合方法及复合蛋白膜 |
| WO2025202394A1 (en) | 2024-03-29 | 2025-10-02 | XAMPLA Ltd. | Bilayer film |
| WO2025202391A1 (en) | 2024-03-29 | 2025-10-02 | XAMPLA Ltd. | Triple layer film |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2002072931A1 (ja) * | 2001-03-14 | 2004-07-02 | 東京農工大学長 | 絹及び絹様材料の繊維及びフィルムの製造方法 |
| US7057023B2 (en) * | 2002-01-11 | 2006-06-06 | Nexia Biotechnologies Inc. | Methods and apparatus for spinning spider silk protein |
| AU2003249366A1 (en) * | 2002-06-24 | 2004-01-06 | Tufts University | Silk biomaterials and methods of use thereof |
| US7160299B2 (en) * | 2003-05-01 | 2007-01-09 | Sherwood Services Ag | Method of fusing biomaterials with radiofrequency energy |
| US7348399B2 (en) * | 2003-08-29 | 2008-03-25 | Louisiana Tech University Foundation, Inc. | Nanofabricated polypeptide multilayer films, coatings, and microcapsules |
-
2006
- 2006-05-03 EP EP20060113438 patent/EP1852470A1/en not_active Withdrawn
-
2007
- 2007-04-13 US US12/226,854 patent/US20090263430A1/en not_active Abandoned
- 2007-04-13 KR KR1020087029623A patent/KR20090023365A/ko not_active Withdrawn
- 2007-04-13 WO PCT/EP2007/003304 patent/WO2007128378A1/en not_active Ceased
- 2007-04-13 AU AU2007247539A patent/AU2007247539C1/en active Active
- 2007-04-13 JP JP2009508152A patent/JP2009535242A/ja not_active Withdrawn
- 2007-04-13 CA CA 2650836 patent/CA2650836C/en active Active
- 2007-04-13 CN CN2007800204740A patent/CN101460570B/zh active Active
- 2007-04-13 RU RU2008146255/04A patent/RU2008146255A/ru not_active Application Discontinuation
- 2007-04-13 EP EP20070724242 patent/EP2013290B1/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200056400A (ko) * | 2017-09-26 | 2020-05-22 | 스파이버 테크놀러지스 에이비 | 표면 활성 거대분자의 구조화 |
| US12059826B2 (en) | 2017-09-26 | 2024-08-13 | Spiber Technologies Ab | Structuring of surface-active macromolecules |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2013290A1 (en) | 2009-01-14 |
| CN101460570A (zh) | 2009-06-17 |
| CA2650836A1 (en) | 2007-11-15 |
| EP2013290B1 (en) | 2013-06-12 |
| AU2007247539A1 (en) | 2007-11-15 |
| CA2650836C (en) | 2014-05-27 |
| AU2007247539C1 (en) | 2013-08-15 |
| RU2008146255A (ru) | 2010-06-20 |
| CN101460570B (zh) | 2012-09-05 |
| AU2007247539B2 (en) | 2013-03-28 |
| US20090263430A1 (en) | 2009-10-22 |
| WO2007128378A1 (en) | 2007-11-15 |
| JP2009535242A (ja) | 2009-10-01 |
| EP1852470A1 (en) | 2007-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20090023365A (ko) | 다층 실크 단백질 필름 | |
| Borkner et al. | Coatings and films made of silk proteins | |
| Rising et al. | Biological materials processing: time-tested tricks for sustainable fiber fabrication | |
| Yang et al. | Artificially engineered protein polymers | |
| Abascal et al. | The past, present and future of protein-based materials | |
| Harrington et al. | Fluid protein condensates for bio-inspired applications | |
| Loo et al. | Self‐assembled proteins and peptides as scaffolds for tissue regeneration | |
| Werkmeister et al. | Recombinant protein scaffolds for tissue engineering | |
| Rammensee et al. | Rheological characterization of hydrogels formed by recombinantly produced spider silk | |
| Hardy et al. | Silk-inspired polymers and proteins | |
| Acharya et al. | Silk fibroin film from non-mulberry tropical tasar silkworms: A novel substrate for in vitro fibroblast culture | |
| Sponner et al. | Characterization of the protein components of Nephila clavipes dragline silk | |
| Hu et al. | Molecular mechanisms of spider silk | |
| Maude et al. | Biomimetic self-assembling peptides as scaffolds for soft tissue engineering | |
| Desai et al. | Protein‐based functional nanomaterial design for bioengineering applications | |
| Wang et al. | Fibrous proteins and tissue engineering | |
| Martens et al. | Triblock protein copolymers forming supramolecular nanotapes and pH-responsive gels | |
| Melrose | High performance marine and terrestrial bioadhesives and the biomedical applications they have inspired | |
| Hsia et al. | Spider silk composites and applications | |
| Herold et al. | Applicability of biotechnologically produced insect silks | |
| Strader et al. | Encoding structure in intrinsically disordered protein biomaterials | |
| Yazawa et al. | Wild silkworm cocoon waste conversion into tough regenerated silk fibers by solution spinning | |
| Wijerathna et al. | Structure, properties, and functional diversity of spider aciniform silk | |
| Lang et al. | Properties of engineered and fabricated silks | |
| Guo | Insect and animal-originated fibres: silk and wool |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20081203 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
Patent event date: 20111020 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
|
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |