CA2650836C - Multilayer silk protein films - Google Patents

Multilayer silk protein films Download PDF

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Publication number
CA2650836C
CA2650836C CA 2650836 CA2650836A CA2650836C CA 2650836 C CA2650836 C CA 2650836C CA 2650836 CA2650836 CA 2650836 CA 2650836 A CA2650836 A CA 2650836A CA 2650836 C CA2650836 C CA 2650836C
Authority
CA
Canada
Prior art keywords
spider silk
multilayer film
films
multilayer
film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA 2650836
Other languages
English (en)
French (fr)
Other versions
CA2650836A1 (en
Inventor
Thomas Scheibel
Ute Slotta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMSilk GmbH
Original Assignee
AMSilk GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AMSilk GmbH filed Critical AMSilk GmbH
Publication of CA2650836A1 publication Critical patent/CA2650836A1/en
Application granted granted Critical
Publication of CA2650836C publication Critical patent/CA2650836C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2389/00—Characterised by the use of proteins; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31725—Of polyamide
    • Y10T428/3175—Next to addition polymer from unsaturated monomer[s]
    • Y10T428/31754—Natural source-type polyamide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31725—Of polyamide
    • Y10T428/31768—Natural source-type polyamide [e.g., casein, gelatin, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Insects & Arthropods (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Laminated Bodies (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CA 2650836 2006-05-03 2007-04-13 Multilayer silk protein films Active CA2650836C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06113438.3 2006-05-03
EP20060113438 EP1852470A1 (en) 2006-05-03 2006-05-03 Multilayer Silk Protein Films
PCT/EP2007/003304 WO2007128378A1 (en) 2006-05-03 2007-04-13 Multilayer silk protein films

Publications (2)

Publication Number Publication Date
CA2650836A1 CA2650836A1 (en) 2007-11-15
CA2650836C true CA2650836C (en) 2014-05-27

Family

ID=37025251

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2650836 Active CA2650836C (en) 2006-05-03 2007-04-13 Multilayer silk protein films

Country Status (9)

Country Link
US (1) US20090263430A1 (https=)
EP (2) EP1852470A1 (https=)
JP (1) JP2009535242A (https=)
KR (1) KR20090023365A (https=)
CN (1) CN101460570B (https=)
AU (1) AU2007247539C1 (https=)
CA (1) CA2650836C (https=)
RU (1) RU2008146255A (https=)
WO (1) WO2007128378A1 (https=)

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EP2899204B1 (en) 2005-12-30 2017-06-28 Spiber Technologies AB Support for cell culture comprising spider silk proteins and methods for producing the same
JP2010509645A (ja) 2006-11-03 2010-03-25 トラスティーズ オブ タフツ カレッジ ナノパターンが形成されたバイオポリマー光学デバイスおよびその製造方法
US8195021B2 (en) 2006-11-03 2012-06-05 Tufts University/Trustees Of Tufts College Biopolymer optical waveguide and method of manufacturing the same
US8529835B2 (en) * 2006-11-03 2013-09-10 Tufts University Biopolymer sensor and method of manufacturing the same
CN101855239B (zh) * 2007-06-20 2013-11-06 巴斯夫欧洲公司 合成的重复蛋白及其生产和用途
GB2461125A (en) * 2008-06-25 2009-12-30 Spintec Engineering Gmbh A silk membrane for bone graft material
EP2328567A2 (de) 2008-08-08 2011-06-08 Basf Se Wirkstoffhaltige fasernflächengebilde auf basis von biopolymeren, ihre anwendungen und verfahren zu ihrer herstellung
GB2464348A (en) * 2008-10-17 2010-04-21 Spintec Engineering Gmbh Applying a liquid protein onto a permeable surface, and silk mono-filament having specific properties
US9861725B2 (en) 2009-05-28 2018-01-09 Addbio Ab Multilayer protein films, methods of making, and drug delivery devices and biomedical implants employing the films
WO2011069643A2 (en) * 2009-12-08 2011-06-16 Amsilk Gmbh Silk protein coatings
RU2443805C1 (ru) * 2010-08-20 2012-02-27 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет технологии и дизайна" (СПГУТД) Способ получения пленки на основе фиброина шелка для изготовления контактных линз
US9115204B2 (en) 2010-10-27 2015-08-25 Spiber Technologies Ab Spider silk fusion protein structures for binding to an organic target
US20120236298A1 (en) * 2011-03-15 2012-09-20 Michael Josef Stuke Tunable apparatus for performing sers
CN103547255B (zh) * 2011-04-14 2018-07-06 加利福尼亚大学董事会 多层薄膜药物递送装置以及其制造和使用方法
WO2012145594A2 (en) * 2011-04-20 2012-10-26 Trustees Of Tufts College Molded regenerated silk geometries using temperature control and mechanical processing
US9956387B2 (en) * 2011-07-08 2018-05-01 Timothy Brown Article of clothing for applying a pharmaceutical, a pharmaceutical delivery kit and method
US9377409B2 (en) 2011-07-29 2016-06-28 Hewlett-Packard Development Company, L.P. Fabricating an apparatus for use in a sensing application
CA2867464A1 (en) * 2012-03-20 2013-09-26 Trustees Of Tufts College Silk reservoirs for drug delivery
JP6302895B2 (ja) 2012-05-02 2018-03-28 スパイバー テクノロジーズ アーベーＳｐｉｂｅｒ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ａｂ 親和性リガンドとして免疫グロブリン断片を組み込んだクモ糸融合タンパク質の構造
CA2872056A1 (en) 2012-05-02 2013-11-07 Spiber Technologies Ab Spider silk fusion protein structures without repetitive fragment for binding to an organic target
EP2940066B1 (en) * 2012-12-26 2020-02-05 Spiber Inc. Spider silk protein film, and method for producing same
CN103341214B (zh) * 2013-07-08 2014-12-31 苏州大学 一种丝素蛋白膜及其制备方法
WO2015117888A1 (en) * 2014-02-04 2015-08-13 Amsilk Gmbh Coated silk films, methods for the production thereof and uses thereof
CN104323927A (zh) * 2014-11-06 2015-02-04 济南星河康泰贸易有限公司 贻贝粘蛋白在制备皮肤美容化妆品上的应用
JP6693049B2 (ja) * 2015-05-21 2020-05-13 日立化成株式会社 ナノ薄膜転写シート及び転写方法
JP6544040B2 (ja) * 2015-05-21 2019-07-17 日立化成株式会社 フィブロインナノ薄膜、ナノ薄膜シート及び転写方法
CN105297440B (zh) * 2015-11-11 2018-01-12 浙江理工大学 一种对蚕丝接枝改性的方法
EP3207947A1 (en) * 2016-02-17 2017-08-23 Ruprecht-Karls-Universität Heidelberg Bioactive compound delivery assembly
WO2018006037A1 (en) * 2016-07-01 2018-01-04 Trustees Of Tufts College Innervated artificial skin
CN106188923A (zh) * 2016-08-04 2016-12-07 叶剑 一种聚苯乙烯基复合装饰板及其制造方法
US12059826B2 (en) 2017-09-26 2024-08-13 Spiber Technologies Ab Structuring of surface-active macromolecules
JP2021080304A (ja) * 2018-01-26 2021-05-27 Ｓｐｉｂｅｒ株式会社 タンパク質成形体用素材、タンパク質成形体、及びタンパク質成形体の製造方法
JP6743939B2 (ja) * 2019-05-09 2020-08-19 日立化成株式会社 ナノ薄膜転写シート及び転写方法
WO2021113054A2 (en) * 2019-11-13 2021-06-10 Rapp Robert James Spider silk proteins - small particle process and products
CN113652033B (zh) * 2021-08-22 2022-12-06 茂泰(福建)鞋材有限公司 一种贻贝足丝防滑橡胶鞋底的制备方法
US20240002682A1 (en) * 2022-07-01 2024-01-04 Ayro, Inc. Coating gradient property management for sustainable vehicles, systems, methods, and apparatus
CN116285719B (zh) * 2022-09-09 2026-03-24 之江实验室 一种丝素蛋白塑封膜及其制备方法和应用
CN119998363A (zh) 2022-10-03 2025-05-13 赞普拉有限公司 海藻酸盐-淀粉膜
CN116103933B (zh) * 2023-02-21 2024-08-13 现代纺织技术创新中心(鉴湖实验室) 一种高牢度双层组合丝素蛋白涂层织物的制备方法
CN117445491A (zh) * 2023-12-06 2024-01-26 江西丝科生物科技有限公司 一种蛋白膜的复合方法及复合蛋白膜
WO2025202391A1 (en) 2024-03-29 2025-10-02 XAMPLA Ltd. Triple layer film
WO2025202394A1 (en) 2024-03-29 2025-10-02 XAMPLA Ltd. Bilayer film

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CN1247837C (zh) * 2001-03-14 2006-03-29 东京农工大学长代表的日本国 丝和丝样材料的纤维和薄膜的制造方法
US7057023B2 (en) * 2002-01-11 2006-06-06 Nexia Biotechnologies Inc. Methods and apparatus for spinning spider silk protein
EP2662211A1 (en) * 2002-06-24 2013-11-13 Tufts University Silk biomaterials and methods of use thereof
US7160299B2 (en) * 2003-05-01 2007-01-09 Sherwood Services Ag Method of fusing biomaterials with radiofrequency energy
US7348399B2 (en) * 2003-08-29 2008-03-25 Louisiana Tech University Foundation, Inc. Nanofabricated polypeptide multilayer films, coatings, and microcapsules

Also Published As

Publication number Publication date
AU2007247539B2 (en) 2013-03-28
EP1852470A1 (en) 2007-11-07
EP2013290A1 (en) 2009-01-14
CA2650836A1 (en) 2007-11-15
RU2008146255A (ru) 2010-06-20
WO2007128378A1 (en) 2007-11-15
CN101460570A (zh) 2009-06-17
AU2007247539A1 (en) 2007-11-15
US20090263430A1 (en) 2009-10-22
CN101460570B (zh) 2012-09-05
JP2009535242A (ja) 2009-10-01
EP2013290B1 (en) 2013-06-12
AU2007247539C1 (en) 2013-08-15
KR20090023365A (ko) 2009-03-04

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