KR20080112557A - A composition for the treatment or prevention of diarrhea - Google Patents

Abstract

A composition for treating or preventing diarrhea is provided to prevent side effects such as exhaustion or weight loss for the medication period and to have no reduction of the weight increment particularly in case of using in domestic animals. A composition for treating or preventing diarrhea comprises taro extracts, broadleaf plantain extracts, Lonicera japonica Thunb extracts, chestnut extracts and Diospyros kaki extracts. The taro is the taro stem. The broadleaf plantain is 1 or greater selected from a group consisting of leaf of broadleaf plantain, and stem and root. The Lonicera japonica Thunb is the leaf and stem of Lonicera japonica Thunb or their mixture. The chestnut is the inside skin.

Description

Composition for preventing or treating diarrhea {A COMPOSITION FOR THE TREATMENT OR PREVENTION OF DIARRHEA}

1 is a photograph of the skin of the dried chestnut for preparing the extract according to an embodiment of the present invention.

Figure 2 is a photograph taken an extractor for producing an extract according to an embodiment of the present invention.

Figure 3 is a photograph of administering a composition for preventing or treating diarrhea to a calf (bar code number; 203818525) having diarrhea symptoms according to an embodiment of the present invention.

Figure 4 is a photograph of administering a composition for preventing or treating diarrhea in a calf (bar code number; 203818594) having diarrhea symptoms according to an embodiment of the present invention.

Figure 5 is a picture of administering a composition for preventing or treating diarrhea in a calf (bar code number; 203817948) having diarrhea symptoms according to an embodiment of the present invention.

Figure 6 is a photograph of administering a composition for preventing or treating diarrhea in a calf (bar code number; 203817641) having diarrhea symptoms according to an embodiment of the present invention.

[Industrial use]

The present invention relates to a composition for the prevention or treatment of diarrhea comprising taro, monarch, Indongcho and balm, which are natural plants effective for the prevention or treatment of diarrhea, and more particularly, the composition comprising the taro, monarch, ingot and balm. It relates to a composition for preventing or treating diarrhea, further comprising persimmon.

[Private Technology]

Diarrhea is a common problem in clinical practice (Farthing, M.J. (2000) Diarrhea: a significant worldwide problem.International Journal of Antimicrobial Agents 14: 65-69.). Diarrhea is the leading cause of diarrhea, with 34 million people worldwide dying every year. In particular, preschool children make up the majority of deaths due to diarrhea. Acute diarrhea among children, especially in underdeveloped countries, is a major obstacle to growth and physical development by repeating the vicious cycle of infection and malnutrition.

In addition, diarrhea is a common problem in livestock, and in relation to the cause of diarrhea, indigestion and dietary diarrhea associated with breast milk or feed, viral diarrhea due to infection and bacterial diarrhea are particularly problematic. In particular, childhood livestock are known to cause diarrhea by infection of harmful bacteria such as E. coli or Salmonella. When diarrhea occurs in livestock, growth may be stagnant, such as a loss of weight gain due to insufficient absorption of nutrients, and the invention of other diseases due to infection or the like may be a problem due to a decrease in physical strength or resistance.

In particular, in recent years, the livestock industry, which places great importance on economic efficiency, is carrying out overcrowding to raise a large number of livestock in a small area in order to improve production efficiency. In order to promote growth, a large amount of drugs such as antibiotics and antibacterial agents are used.

The use of such drugs as antibiotics or antimicrobial agents not only causes the appearance of resistant bacteria or the stability of livestock products, but also causes a problem of a decrease in weight gain when antibiotics are administered for the prevention or treatment of diarrhea.

Therefore, it is possible to develop a new substance having a prevention or treatment effect of diarrhea that does not reduce the weight gain of livestock among natural products that do not cause relatively stability problems and do not cause problems such as the emergence of resistant bacteria such as antibiotics or antibacterial agents. The demand to do so is increasing.

The present invention has been made to solve the same problems as the prior art, the present invention is excellent in the anti-diarrhea and excellent ability to reduce bowel deficiency and excellent antidiarrheal effect, there are side effects such as dehydration phenomenon or decrease in the weight gain of livestock during the administration period It is not intended to provide a composition for treating or preventing diarrhea that is harmless to humans or livestock.

Another object of the present invention is to provide a method for preparing a composition for treating or preventing diarrhea that is free of side effects and is safe using natural plants.

In order to achieve the above object, the present invention provides a composition for the prevention or treatment of diarrhea, including taro, quenosa, Indongcho and balm. The present invention also provides a composition for preventing or treating diarrhea further comprising persimmon tree in the composition.

The present invention also provides a method for preparing the composition for preventing or treating diarrhea.

Hereinafter, the present invention will be described in detail.

The present invention relates to a composition for preventing or treating diarrhea, including a taro extract, a quince extract, Indongcho extract and a chestnut extract.

In addition, the present invention may be to include persimmon extract in addition to the composition for the prevention or treatment of diarrhea, including the taro extract, the quince extract, Indongcho extract and chestnut extract.

In the present invention, taro ( Colocasia antiquorum var. Esculenta ) refers to a vegetable that is also called a sparse. The taro is a perennial herb of the monocotyledonous plant Cheonnamseong Mok Cheonnamseong, native to tropical Asia, mainly distributed in Korea, India, Indonesia, etc., breeds with egg trunks, and grows well in slightly humid places. Mainly use egg in the ground for food. In the present invention, the taro may preferably be a taro stem.

In the present invention, the plantago major var. Japonica is also called a chachocho or scallop, and refers to a perennial herb that grows mainly on sunny beaches. The pterygium is a perennial herb of the dicotyledonous plant plywood group psyllium apaceae, distributed mainly in Korea and Japan, mainly used for edible leaves, mainly used for medicinal seeds. In the present invention, the plantain may be at least one selected from the group consisting of leaves, stems, and roots of the plantain.

In the present invention, Indongcho refers to Lonicera japonica Thunberg or other related plants of the same genus, and is also called Indong, Geumeundong, Geumeunhwa or Tongyeongcho. Phosphorus in the present invention may be preferably the stem and leaves of the phosphorus.

In the present invention, chestnut refers to the fruit of chestnut and is also called a ruler. The chestnut is native to Asia, Europe, North America, Northern Africa, and the like, and preferably may be Korean chestnut. In the present invention, the chestnut may be preferably the inner skin (shell) of the chestnut.

In the present invention, persimmon ( Diospyros kaki ) is called shisu and refers to a special species of temperate East Asia. The persimmon tree is a deciduous broad-leaved arborescent tree of the dicotyledon persimmon tree persimmon tree, fruit trees widely cultivated in central China, north Korea, Japan and south central Korea, preferably may be cultivated in Korea. Persimmon tree in the present invention may be preferably the leaves of persimmon tree.

In the present invention, the extract refers to an active ingredient separated from natural products, that is, a material showing a desired activity, and is usually prepared by an extraction process using water, an organic solvent or a mixed solvent thereof, and water, an organic solvent or a mixture thereof. Extracts of solvents, dry powders thereof or any form formulated therewith. In addition, the extract also includes a fraction obtained by the extraction through the extraction process.

The solvent of the extract of the present invention may be water, an organic solvent or a mixed solvent thereof, and specifically, a polar solvent such as lower alcohol having 1 to 4 carbon atoms such as water, methanol, ethanol, ethyl acetate, etc., and hexane or dichloromethane. It may be an organic solvent such as a non-polar solvent or a mixed solvent thereof, preferably water, a low alcohol having 1 to 5 carbon atoms or a mixed solvent thereof, more preferably water or 50% to 100% ethanol And most preferably water.

The solvent of the extract of the present invention may be added in an appropriate amount depending on the type of plant, or may be added in the same amount with respect to taro, cactus, indongcho, chestnut or persimmon leaves. The content of the plant and the extraction solvent to be extracted of the extract is 1: 2 (kg / L) to 1: 500 (kg / L), preferably 1: 10 (kg / L) to 1: 100 (kg / L) It may be, but is not limited thereto. Can be added. Specifically, the extract of the present invention is 1 g of water, 1 g to 50 g of perilla leaf, 10 g to 200 g, Indongcho 10 g to 200 g, chestnut 5 to 100 g, taro 1 g to 50 g, persimmon leaf per 1 L of water , Preferably, may be extracted by adding a mixture of 75 g to 150 g of royal diameter, 75 g to 150 g of Indongcho, 30 g to 70 g chestnut skin, 5 g to 25 g taro, 5 g to 25 g persimmon leaf have.

The extract may be prepared according to the conventional method for producing a plant extract. Specifically, the method comprises the steps of pulverizing the dried taro, royal porridge, indongcho, chestnut or persimmon leaf, respectively, and extracting with a solvent, the step of filtering the extract obtained by the extraction step or the filtration step It may further include the step of concentrating the filtrate obtained by. The plant extract may be prepared by performing a separate extraction process for each plant or by mixing the ground milled plant powder to prepare a mixture, and then performing the extraction process on the mixture. In addition, the manufacturing method may further include a step of drying the concentrated filtrate.

The preparation temperature of the extract may be 50 ° C to 150 ° C, preferably 70 ° C to 120 ° C, more preferably 80 ° C to 110 ° C, but is not limited thereto. Extraction time of the extract is not particularly limited, but may be 1 hour to 24 hours, preferably 2 hours to 5 hours, it may be used a conventional extraction device, ultrasonic grinding extractor or fractionator. The filtration process may be carried out by vacuum filtration, and the drying process may be performed by freeze drying.

Specifically, the extract of the present invention is prepared by immersing the plant in water of 10 ℃ to 20 ℃ 6 hours to 36 hours, preferably 12 hours to 24 hours, more preferably 15 hours to 20 hours After the extraction of the mixed solution in which the plant is immersed at 100 ℃ for 2 hours, preferably at 100 ℃ for 1 hour, the extraction process by extracting the temperature of the mixed solution for 1 hour while lowering the temperature from 100 ℃ to 80 ℃ After performing, it may be prepared by performing a filtration process by vacuum filtration.

In addition, the extract may be further subjected to the fractionation process. The fractionation process may be performed with a solvent selected from the group consisting of hexane, methylene chloride, acetone, ethyl acetate, chloroform, water, and mixtures thereof, and the fractionation solvent may be used two or more. The fraction may be used sequentially according to the polarity of the solvent to prepare each solvent extract. The fraction may be performed by adding a fractional solvent in a volume ratio of 1: 0.1 to 1:10 with respect to the extract to be fractionated.

In addition to the above components, the plant extract of the present invention is a nutrient, vitamin, electrolyte, flavoring agent, coloring agent, neutralizing agent, pectic acid and salts thereof, alginic acid and salts thereof, organic acid, protective colloid thickener, pH adjusting agent, stabilizer, preservative, glycerin , Alcohols, carbonation agents used in carbonated drinks, and the like may be further contained. The components may be added to the plant extract independently or in combination. The content of the additional component may be preferably added in the range of 0.1 to 20 parts by weight per 100 parts by weight of the plant extract.

The content of the plant to be extracted in the composition of the present invention is based on 100 parts by weight of the taro, the royal diameter is 100 to 2000 parts by weight, preferably 500 to 1500 parts by weight, more preferably 800 It may be used in parts by weight to 1200 parts by weight, the copper candle may be used in 100 parts by weight to 2000 parts by weight, preferably 500 parts by weight to 1500 parts by weight, more preferably 800 parts by weight to 1200 parts by weight, 50 parts by weight to 1000 parts by weight, preferably 200 parts by weight to 750 parts by weight, and more preferably 350 parts by weight to 450 parts by weight, and the persimmon leaf is 10 parts by weight to 500 parts by weight, preferably 50 parts by weight. To 250 parts by weight, more preferably 75 to 150 parts by weight. The inventors of the present invention produced the composition in various mixing ratios of the plants, when the composition is prepared in a weight ratio within the above range, the composition for preventing or treating diarrhea shows an excellent diarrhea inhibitory effect, there are no side effects such as weight gain reduction Confirmed.

An embodiment of the present invention provides a composition for the prevention or treatment of diarrhea comprising a taro extract, a quince extract, Indongcho extract, chestnut extract and persimmon extract.

Diarrhea in the present invention is the discharge of feces in liquid or near liquid at random, diarrhea caused by infection, such as dysentery, bacterial food poisoning, cholera, viral diarrhea, bacterial diarrhea or parasitic diarrhea, indigestion diarrhea, axial diarrhea , Allergic diarrhea, neurological diarrhea, addictive diarrhea, and the like, and all, preferably may be dysentery, dyspeptic diarrhea, viral diarrhea or bacterial diarrhea. The indigestion diarrhea may be indigestion or dietary diarrhea associated with breast milk or feed in the case of livestock. The dysentery, also known as erythema or hari, refers to a disease that causes diarrhea with blood as an infectious disease of the digestive system that develops epidemic or acutely. There are mainly bacterial and amoeba traits.

The subject of the composition for preventing or treating diarrhea of the present invention may be an animal including a cow and a human. The present invention may preferably be a composition for preventing or treating diarrhea in a livestock, more preferably, a composition for preventing or treating diarrhea in a cow, and most preferably, may be a composition for preventing or treating diarrhea in a calf. In the case of a calf, diarrhea due to diarrhea may severely lead to a coma, and therefore, diarrhea of the calf requires rapid treatment. In view of the above, without further administration of antibiotics, it is possible to quickly treat diarrhea of a calf with diarrhea, ie, a calf, so that the most preferred application of the present invention may be prevention or treatment of diarrhea of the calf.

In the present invention, the animal includes mammals, fish, and poultry, and mainly means organisms in which organic matter is consumed as nutrients, and digestion, excretion, and respiratory organs are differentiated. The mammal may be a pig, a cow, a sheep, a goat, a dog, a cat, and may further include experimental rodents belonging to the mammalian river and fur-owned or ornamental animals. The experimental rodent may include a rat, mouse, hangster or gerbilus rat, the fur-owned animal may be a mink or a fox, and the ornamental animal may be a zoo animal including a monkey or a tailless monkey. Can be. The fish refers to vertebrates that live in water belonging to the taxonomy of fish rivers (魚 上 綱), including carp or goldfish. The algae may include poultry such as pheasants, chickens, ducks or turkeys.

The livestock refers to animals that are useful for human life, such as providing human products or using them for ministry as humans are pure and improved wild animals, preferably pigs, cattle, horses, sheep, goats, dogs, and cats belonging to mammals. , Rabbit, and the like, more preferably cow.

The composition for preventing or treating diarrhea of the present invention includes a taro extract, a royal myrtle extract, an indocho extract and a chestnut extract as an active ingredient or includes a taro extract, a royal mycelium extract, an indocho extract, a chestnut extract and a persimmon extract as an active ingredient, The active ingredient may be included in an amount of 0.001 to 99.99% by weight, preferably 0.1 to 99% by weight, based on the total weight of the composition.

In addition, the composition for preventing or treating diarrhea or a medicament for preventing or treating diarrhea containing the composition may further include appropriate carriers, excipients and diluents commonly used in the preparation thereof.

In addition, the composition for preventing or treating diarrhea or a drug for preventing or treating diarrhea of a cow including the composition may be used in an oral dosage form of powder, granules, tablets, suspensions, emulsions, syrups, etc. according to conventional methods, respectively. .

Carriers, excipients and diluents which may be included in the composition for preventing or treating diarrhea or a medicament for preventing or treating diarrhea of a cow comprising the composition include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, Maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate Rate and mineral oil. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and the solid preparations may include at least one excipient such as starch, calcium carbonate, sucrose in the extract. ) Or lactose, gelatin and the like are mixed. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid preparations for oral use include suspensions, solvents, emulsions, and serums.In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have.

The preferred dosage of the composition for preventing or treating diarrhea or the agent for preventing or treating diarrhea of a cow including the composition is dependent on the condition and weight, the degree of disease, the form of the drug, the route of administration and the duration of the present invention. May be appropriately selected. Preferably from 0.001 cc / kg (composition / body weight) to 1000 cc / kg (composition / cow body weight) per day based on the composition for preventing or treating diarrhea of the present invention, 0.01 cc / kg (composition) Per cow body weight) to 500 cc / kg (composition / body weight). The number of administration may be administered once a day, or divided into several times, preferably administered once a day, but is not limited thereto because it can be easily adjusted according to the weight of the patient, the degree of the disease, sex and history. The dosage does not limit the scope of the invention in any aspect.

In addition, the present invention relates to a method for producing a composition for preventing or treating diarrhea, including taro, apocalypse, Indongcho, balm and persimmon.

The manufacturing method

a) chopping the taro, the royal family, Indongcho, chestnut and persimmon, and mixing to prepare a mixture;

b) immersing the mixture in an extraction solvent to prepare a mixed solution; And

c) extracting the mixed solution prepared by dipping

It relates to a method for producing a composition for preventing or treating diarrhea comprising a.

The a) step may be carried out by washing the taro, royal family, Indongcho, chestnuts and persimmon with water, air-dried and finely chopped to 0.1 cm to 30 cm, preferably 1 cm to 10 cm. The taro may be a taro stem, the pterygium may be at least one selected from the group consisting of leaves, stems and roots, the indocho may be leaves, stems or mixtures of them, the chestnut is the inner skin of the chestnut The persimmon tree may be a leaf of the persimmon tree.

The mixture may be used based on 100 parts by weight of the taro, the royal diameter of 100 parts by weight to 2000 parts by weight, preferably 500 parts by weight to 1500 parts by weight, more preferably 800 parts by weight to 1200 parts by weight, The copper foil may be used in an amount of 100 parts by weight to 2000 parts by weight, preferably 500 parts by weight to 1500 parts by weight, more preferably 800 parts by weight to 1200 parts by weight, and the chestnut is 50 parts by weight to 1000 parts by weight, preferably Is 200 parts by weight to 750 parts by weight, more preferably 350 parts by weight to 450 parts by weight, the persimmon leaf is 10 parts by weight to 500 parts by weight, preferably 50 parts by weight to 250 parts by weight, more preferably It can be prepared by mixing 75 parts by weight to 150 parts by weight.

The extraction solvent may be water, an organic solvent or a mixed solvent thereof, and specifically, a polar solvent such as lower alcohol having 1 to 4 carbon atoms such as water, methanol, ethanol, ethyl acetate, and the like, and a nonpolar solvent of hexane or dichloromethane. The same organic solvent or a mixed solvent thereof, preferably water, a low alcohol having 1 to 5 carbon atoms or a mixed solvent thereof, more preferably water or 50% to 100% ethanol, Most preferably water.

The extraction solvent of step b) may be added in an amount of 0.1: 1 to 0.5: 1 (kg / L) to the total weight of the toran, the royal family, Indongcho, chestnut and persimmon radish which are the extraction targets, specifically 1 L of the extraction solvent. 5 g to 25 g of taro, 75 g to 150 g of bovine diameter, 75 g to 150 g of Indongcho, 30 g to 70 g of chestnut skin, and 5 g to 25 g of persimmon leaf may be added.

The step b) is 6 hours to 36 hours, preferably 12 hours to 24 hours, more preferably 15 hours to 20 hours, the mixture in an extraction solvent of 5 ℃ to 30 ℃, preferably 10 ℃ to 20 ℃ It can be carried out by a method of dipping.

Step c) may be performed by a conventional method for preparing a plant extract, and may use a conventional extractor, an ultrasonic mill extractor or a fractionator. The preparation method of the extract may be preferably a hot water extraction method.

The extraction temperature of the extraction step may be 50 ° C to 150 ° C, preferably 70 ° C to 120 ° C, more preferably 80 ° C to 110 ° C. Extraction time of the extract is not particularly limited, but may be 1 hour to 24 hours, preferably 2 hours to 5 hours.

The step c) may be preferably performed by adding heat to the immersed mixed solution for 2 hours at 80 ℃ to 110 ℃.

In addition, after performing the extraction step, the step of filtering the extract obtained by the extraction step or the step of concentrating the filtrate obtained by the filtration step may be further included. In addition, the manufacturing method may further include a step of drying the concentrated filtrate. The filtration process may be carried out by vacuum filtration, and the drying process may be performed by freeze drying.

 In addition, after performing the extraction step, the filtration step or the drying step, the fractionation process may be further performed. The fractionation process may be performed with a solvent selected from the group consisting of hexane, methylene chloride, acetone, ethyl acetate, chloroform, water, and mixtures thereof, and the fractionation solvent may be used two or more. The fraction may be used sequentially according to the polarity of the solvent to prepare each solvent extract. The fraction may be performed by adding a fractional solvent in a volume ratio of 1: 0.1 to 1:10 with respect to the extract to be fractionated.

Specifically, the preparation of the composition for preventing or treating diarrhea may be carried out by immersing the taro, royal myrtle, Indongcho, chestnut and persimmon leaves in water of 10 ° C. to 20 ° C. for 18 hours, and then heating to 100 ° C. using a boiling water method. After extraction for 2 hours at 100 ° C., preferably for 1 hour at 100 ° C., the extraction was carried out by extracting the temperature of the mixed solution for 1 hour while lowering the temperature from 100 ° C. to 80 ° C., followed by reduced pressure filtration. It can be prepared by performing a filtration process.

Hereinafter, a preferred embodiment of the present invention. However, the following examples are only presented to aid the understanding of the present invention, and the present invention is not limited to the following examples.

EXAMPLE

Example 1 Preparation of a Composition for Preventing or Treating Diarrhea

After washing taro stems, leaves and stems of Indongcho, royal leaves, stems and roots, chestnut skin and persimmon leaves collected from Goheung-gun, Jeollanam-do, Korea three times in running water and drying them in a well-ventilated place, Using small beans to chop into 1 cm to 10 cm in size to prepare the plant to be extracted.

500 g of the taro stems, 5000 g of Indongcho, 5000 g of chestnut, 2000 g of chestnut skin and 500 g of persimmon leaves (persimmon leaves) were added to 45 L of water at 10 ° C., and the mixture was immersed for 18 hours to prepare a mixed solution.

After the mixture was boiled to 100 ° C. while slowly raising the temperature using a water bath, the temperature was maintained for 1 hour, and after 1 hour, after performing hot water extraction for 1 hour while lowering the temperature to 80 ° C., Decompression filtration was performed to prepare a composition for preventing or treating diarrhea.

Example 2 Measurement of Diarrhea Treatment Effect

45 of 791 Korean cattle with diarrhea among Jukam Farm (Jukam Farming Co., Ltd.) located at 989, Jangdeok-ri, Donggang-myeon, Goheung-gun, Jeollanam-do, Korea. Mix was administered.

Administration of the composition was administered by oral feeding using a sterile bottle, the dosage was administered 10 cc per kg of condensed body weight, the number of salaries were once a day, 1 in the case of severe constriction One to three more days were administered, and the change in body weight after administration was confirmed to confirm the treatment of diarrhea symptoms and the reduction of weight gain following administration of the composition. Table 1 and Table 2 below shows the information on the calf and the dose, weight change, and diarrhea symptoms of the cyclized calf administered with the composition prepared in Example 1.

TABLE 1

TABLE 2

As shown in Table 1 and Table 2, only one to two doses of the composition of the present invention treated or improved diarrhea in 36 out of 45 total administration group, the calf of the most administered calf In this case, it was confirmed that there was a very good branch effect four times. In particular, in the case of calves, if the symptoms of diarrhea last longer, dehydration and coma due to malnutrition may occur, which requires rapid treatment and improvement of diarrhea symptoms. Improved is an industrially effective effect in the livestock industry.

In addition, a large number of calves gained weight after administration of a composition for preventing or treating diarrhea, and there was no case in which the body weight was reduced, and there were no side effects such as a decrease in weight gain. This effect was interpreted to be because the composition for preventing or treating diarrhea of the present invention is all made of a natural plant because there is no side effect and excellent stability. In addition, it was not directly confirmed by this experiment, but the above results did not use antibiotics or antibacterial substances, and thus the excellent effect of treating diarrhea symptoms without any problems of resistant bacteria or livestock stability was recognized. Was interpreted.

The composition for preventing or treating diarrhea of the present invention is excellent in inhibiting indigestion or dietary diarrhea and viral or bacterial diarrhea and excellent in reducing bowel deficiency, and thus has excellent antidiarrheal effect. Since there are no side effects such as weight loss, especially when used in livestock such as cattle, it can be very useful industrially because it can exhibit the branch effect without reducing the weight gain.

Claims (8)

A composition for preventing or treating diarrhea comprising a taro extract, a royal mystery extract, Indongcho extract and chestnut extract. The composition for preventing or treating diarrhea according to claim 1, wherein the composition further comprises persimmon extract. The method according to claim 1 or 2, The taro is a taro stem, the pterygium is at least one selected from the group consisting of the leaves, stems and roots of the pterygium, the dongdongcho is a leaf, stalk or a mixture of them, the chestnut is the skin of the chestnut diarrhea Prophylactic or therapeutic composition. The method of claim 2, The persimmon is a persimmon leaf diarrhea prevention or treatment composition. The method according to claim 1 or 2, The content of the plant to be extracted is 100 parts by weight of the taro, 100 parts by weight to 2000 parts by weight, the ingot is 100 parts by weight to 2000 parts by weight, 50 parts by weight to 1000 parts by weight of the chestnut Diarrhea preventing or treating composition comprising a part. The method of claim 2, Based on 100 parts by weight of the taro, the persimmon is a diarrhea prevention or treatment composition comprising 10 parts by weight to 500 parts by weight. The method according to claim 1 or 2, The composition for preventing or treating diarrhea is a composition for preventing or treating diarrhea that is for preventing or treating diarrhea of a calf. a) chopping the taro, the royal family, Indongcho, chestnut and persimmon, and mixing to prepare a mixture; b) preparing the mixture by immersing the mixture in water for 12 to 24 hours; And c) extracting the mixed solution prepared by dipping by hot water extraction method Method for producing a composition for preventing or treating diarrhea comprising a.

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