KR20080104027A - Emulsion composition - Google Patents

Abstract

Disclosed is an emulsion composition comprising algecolloid or hyaluronic acid (preferably both of algecolloid and hyaluronic acid) and a silk powder. The emulsion composition shows a smooth feeling upon use when used as a preparation for external application to the skin.

Description

Emulsion composition {EMULSION COMPOSITION}

The present invention relates to an emulsified composition containing algocolloid and / or hyaluronic acid and having a smooth feeling, in particular, an emulsified composition suitable for use for external preparations for skin.

Algal colloids and hyaluronic acid are all known components for excellent moisturizing action and blood circulation promoting action, and are widely used in cosmetics and the like. Alga colloid is a natural component extracted from brown algae, and is composed mainly of alginic acid, a polysaccharide consisting of β-1,4-linkages of D-mannuronic acid. Alga colloids are known to have an excellent moisturizing effect, as well as a beautiful skin texture. Hyaluronic acid is a substance having a repeating structure of a disaccharide composed of β-glycosidic bonds of glucuronic acid and N-acetylglucosamine, and is a high molecular compound having a molecular weight of several million. Since hyaluronic acid has a very long acidic sugar chain, it has a high catchment capacity.

Examples of cosmetics containing both algocolloids and hyaluronic acid include (A) extracts of plants of the Lythraceae family of Lagerstroemia L. and (B) whitening agents such as brown seaweed extracts (algecolloids) and antioxidants. Skin cosmetics (the following patent document 1) which contain 1 or more types of physiologically active ingredients selected from the group which consists of moisturizing agents, such as an anti-inflammatory agent, a ultraviolet protective agent, and hyaluronic acid, a cell activator, and a blood flow promoter, Can be. However, the emulsion composition containing alga colloid and hyaluronic acid had the drawback that the smoothness at the time of use is lacking, and the usability is bad.

By the way, silk powder is a water-insoluble protein powder which comprises the silk fiber obtained from the cocoon of Gajam. As the efficacy of the silk powder, ultraviolet absorbing action, antibacterial action and antibacterial action are known.

Patent Document 1: Japanese Patent Application Laid-Open No. 2005-139070

<Start of invention>

Problems to be Solved by the Invention

An object of this invention is to provide the emulsion composition which has a smooth usability containing an algal colloid and / or hyaluronic acid.

Means for solving the problem

MEANS TO SOLVE THE PROBLEM As a result of earnestly researching in order to solve the said subject, the present inventors discovered that the smoothness at the time of use improves by mix | blending the silk powder which is powder to the emulsion composition containing an algal colloid and / or hyaluronic acid, The present invention has been completed.

(1) An emulsified composition containing algocolloid and / or hyaluronic acid, and silk powder.

(2) The emulsion composition of (1), which contains an algocolloid, hyaluronic acid, and silk powder.

(3) The emulsion composition according to (1) or (2), wherein the emulsion composition is an oil-in-water emulsion composition.

(4) The emulsion composition according to any one of (1) to (3), which is a skin external preparation.

Effect of the Invention

By mix | blending a silk powder with the emulsion composition containing an algal colloid and / or hyaluronic acid, the smoothness at the time of using it as a skin external preparation can be improved. Moreover, the smoothness at the time of use of an emulsion composition can further be improved by mix | blending a silk powder with the emulsion composition which mix | blended alga colloid and hyaluronic acid.

Best Mode for Carrying Out the Invention

The emulsion composition of the present invention contains one or both of algocolloid and hyaluronic acid and silk powder. It is preferable that the emulsion composition of this invention contains both an algocolloid and a hyaluronic acid.

In this invention, the smoothness at the time of use shows the absence of the friction feeling which the finger to apply or the skin of an application part feel at the time of application | coating of an emulsion composition to the skin. Such usability can generally be evaluated from rheological characteristics, such as a viscosity, in addition to the sensory evaluation by panelists.

In the present invention, algocolloid is a natural component extracted from brown algae and contains alginic acid as a main component. Alginic acid is a polysaccharide consisting of β-1,4-linkages of D-mannuronic acid. Examples of the alga colloid include alga colloids (manufactured by BOTTGER Corporation) and alga colloid-S (manufactured by BOTTGER Corporation).

Although the amount of the algal colloid is not particularly limited, it is preferably 0.001 to 5% by weight, more preferably 0.005 to 2% by weight, particularly preferably 0.01 to 1% by weight based on the total amount of the emulsion composition.

In the present invention, hyaluronic acid is a substance having a repeating structure of a disaccharide composed of β-glycosidic bonds of glucuronic acid and N-acetylglucosamine, and is a high molecular weight compound having a molecular weight of several million and its salt. Although the molecular weight of hyaluronic acid used for this invention is not specifically limited, 10,000-5 million are preferable, and 100,000-2 million are especially preferable. The hyaluronic acid may be a salt, and the salt of the hyaluronic acid may be a metal salt such as sodium salt, potassium salt, lithium salt, magnesium salt or calcium salt, basic amino acid salt such as lysine salt, arginine salt or histidine salt, ammonium salt or triethanolamine salt. And organic salts such as diisopropanolamine salt, and sodium hyaluronate is particularly preferable. Examples of such hyaluronic acid include sodium hyaluronate HA12 (manufactured by Shiseido).

Although the hyaluronic acid compounding quantity is not specifically limited, 0.001-5 weight% is preferable with respect to the emulsion composition whole quantity, More preferably, it is 0.005-2 weight%, Especially preferably, it is 0.01-1 weight%.

In the present invention, the silk powder is a water-insoluble protein powder constituting silk fibers obtained from the cocoon cocoon, and contains fibroin as a main component. Examples of the silk powder include silkgen G powder (manufactured by Ichimaru Rucos Co., Ltd.), silk ID powder K-50 (manufactured by Idemitsu Petrochemical Co., Ltd.), and the like. In addition, the silk powder referred to in the present invention may be one having a variety of additional effects by modifying the surface. For example, as a commercial item, silk ID powder A-705 (made by Idemitsu Petrochemical Co., Ltd.), silk ID powder S-702 (made by Idemitsu Petrochemical Co., Ltd.), silk ID powder L-710 (made by Idemitsu Petrochemical Co., Ltd.), etc. are mentioned.

Although the silk powder compounding quantity is not specifically limited, 0.001-5 weight% is preferable with respect to emulsion composition whole quantity, More preferably, it is 0.01-2 weight%, Especially 0.1-1 weight% is preferable.

In the emulsion composition of the present invention, the relative ratio of the compounding amount of the alga colloid and the silk powder is not particularly limited, but from the viewpoint of the usability such as smoothness, when the compounding amount of the silk powder is 1, the algocolloid is 0.005 to 100. It is preferable, it is more preferable that it is 0.01-10, and it is especially preferable that it is 0.02-1. In addition, the relative ratio of the blending amount of hyaluronic acid and the silk powder is not particularly limited, but from the viewpoint of the usability such as smoothness, when the blending amount of the silk powder is 1, the hyaluronic acid is preferably 0.002-50, and 0.005 It is more preferable that it is -5, and it is especially preferable that it is 0.01-0.5. Even when the emulsion composition of this invention contains both alga colloid and hyaluronic acid, the preferable relative ratio of the compounding quantity of each and silk powder is the same as the above.

In the present invention, the emulsified form of the emulsified composition is applied to a multi-layer emulsified composition such as an oil-in-water emulsified composition and a water-in-oil emulsified composition, and an oil-in-water emulsified composition and a water-in-oil emulsified composition. From the viewpoint of the usability, an oil-in-water emulsified composition is particularly preferable. The relative ratio of water and oil in the emulsifier composition of the present invention is not particularly limited, but is preferably water: oil = 2: 1 to 100: 1, particularly preferably from the viewpoint of the usability such as a fresh feeling. Is moisture: oil = 4: 1-50: 1.

In the present invention, as an oil component, avocado oil, macadamia nut oil, corn oil, olive oil, rapeseed oil, evening primrose oil, castor oil, sunflower oil, tea seed oil, wild chafing oil, rice bran oil, jojoba oil, cacao oil, palm oil, Stearic Acid, Cetanol, 1,3-Butylene Glycol, Swlene, Squalene, Tallow, Beeswax, Beeswax, Candelilab, Carnabanab, Horned Bees, Lanolin, Liquid Paraffin, Polyoxyethylene (8 mol) Oleyl Alcohol ether, glyceryl monooleate, octylate dodecyl, cyclomethicone, dimethylpolysiloxane, diphenylpolysiloxane, and the like. Dodecyl and 1,3-butylene glycol are preferable. Moreover, 0.5-40 weight% is preferable with respect to emulsion composition whole quantity, More preferably, it is 2-30 weight%, and 3-20 weight% is especially preferable. By making the compounding quantity of the oil component in an emulsion composition into the above-mentioned range, a sticky feeling at the time of use of a composition is suppressed.

The emulsifier used in the present invention is not particularly limited as long as it is used in an external preparation for skin, and for example, anionic surfactants such as alkyl sulfates, acylamine salts, and fatty acid salts, polyoxyalkylene alkyl ethers, and polyoxyalkylene resins. Nonionic surfactants such as anti-acid esters, polyoxyalkylenedahydric alcohol fatty acid esters, polyhydric alcohol fatty acid esters, sucrose fatty acid esters, cationic surfactants such as tetraalkylammonium salts, betaine type, sulfobetaine type, sulfoamino acid type, and imida. Amphoteric surfactants, such as a zolinium type, a lecithin, and a leso lecithin, are mentioned, Especially glycerol monostearate and hydrogenated soybean phospholipid are preferable.

In the emulsion composition of the present invention, a whitening component, an anti-inflammatory component, an antioxidant component, a thickener, a preservative, a stabilizer, a humectant, a pH adjuster, a fragrance, and the like can be blended.

As a whitening component, ascorbic acid and its derivatives and salts thereof, vitamin A or its derivatives, pantothenic acid or its derivatives, hydroquinone and its derivatives such as arbutin, resorcin and its derivatives such as ellagic acid, kojic acid and rucinol, chamomile ET, Cysteine and its derivatives and salts thereof, glabridine, glabrene, liquiritin, isoriquiritin, ferulic acid and its derivatives and salts thereof, caffeic acid and its derivatives and salts thereof, and the like. In the extract, extracts, placenta extracts, licorice extracts, chamomile extracts, animal and plant extracts containing carotenoids, asparagus extracts, pea extracts, Youngsil extracts, golden extracts, ononis extracts, raspberry extracts, red ginseng extracts, cinnamon extracts, Ogapi extract, coffee extract, rice bran extract, wheat germ extract, sessin extract, hawthorn extract, mountain migraine extract, white lily extract, peony extract, capillary extract, soybean extract, tea extract, molasses extract, tomato extract, white lotus extract, Beech bud extract, grape extract, flode manita extract, hop extract, anchovy extract, Chinese quince extract, pancreas extract, eucalyptus extract, uiyiin extract, and hanja extract.

As an anti-inflammatory component, allantoin, calamine, glycylic acid or derivatives thereof, glycylic acid or derivatives thereof, zinc oxide, guaiazulene, tocopherol acetate, pyridoxine hydrochloride, menthol, camphor, terebin oil, indomethacin, salicylic acid Or derivatives thereof.

As antioxidant components, tocopherol and its derivatives, butylhydroxyanisole, dibutylhydroxytoluene, sodium bisulfite, erythorbic acid and its salts, flavonoids, glutathione, glutathione peroxidase, glutathione-S-transferase, catalase, super Oxide dismutase, thiolidoxin, taurine, thiotaurine, hypotaurine and the like.

Examples of the thickener include sodium carboxymethyl cellulose, carboxyvinyl polymer, hydroxyethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate, polyvinyl alcohol, locust bean gum, guar gum, gelatin, hydroxypropylmethylcellulose, and the like.

Paraoxybenzoic acid ester, benzalkonium chloride, etc. are mentioned as a preservative.

Examples of the stabilizer include sodium sulfite, sodium bisulfite, dibutylhydroxytoluene, butylhydroxyanisole, edetic acid or salts thereof.

Examples of the humectant include polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, isopropylene glycol, and polyethylene glycol.

As a pH adjuster, amines, such as inorganic acids, such as hydrochloric acid, organic acids, such as a citric acid, alkali hydroxides, such as potassium hydroxide and sodium hydroxide, triethanolamine, diethanolamine, and diisopropanolamine, are mentioned.

As the fragrance, spearmint oil, peppermint oil, linalool, winder green oil, sasapras oil, cloves oil, peppermint oil, thyme oil, sage oil, eucalyptus oil, lavender oil, marjoram oil, broiler oil, lime oil, lemon oil and orange oil And natural flavors such as l-menthol and dl-camphor.

Although the formulation of the emulsion composition of this invention is not restrict | limited, A cream, a lotion, an emulsion, emulsion ointment, etc. are mentioned, Especially a cream, a lotion, and an emulsion are preferable.

The emulsion composition of the present invention may be prepared by mixing necessary components such as an emulsifier with an aqueous phase or an oil phase, and if necessary, after heating and dissolving, mixing and emulsifying the aqueous phase and the oil phase. As the emulsification method used in the present invention, a general emulsification method can be employed, and emulsification can be performed using a colloid mill, a homomixer, a high pressure homogenizer, an ultrasonic emulsifier, or the like.

The emulsion composition of the present invention can be suitably used as an external preparation for skin, such as a cosmetic for external skin or a therapeutic agent for dry skin diseases, for example, by the smoothness, moisturizing effect, etc. at the time of use thereof, but the present invention is limited thereto. It is not. The usage-amount and frequency of use of the emulsion composition of this invention are not specifically limited, It can select suitably according to a use purpose.

Although an Example demonstrates this invention concretely in detail below, this invention is not limited to these.

Example 1

Alg colloid (alge colloid: BOTTGER Co.) 0.1 g, sodium hyaluronate (sodium hyaluronate HA12: Shiseido Co., Ltd.) 0.05 g, concentrated glycerin 1 g, carboxyvinyl polymer (Cabopol Ultrez 10: manufactured by Noveon) and hydroxide 0.25 g of potassium was added to 85.7 g of purified water, and the resultant was heated to 80 ° C as an aqueous phase. Meanwhile, 3 g of stearic acid, 4 g of acidified oil, 0.4 g of jojoba oil, 0.2 g of cetanol, and 1 g of monostearate glycerin (Nikol MGS-BMV: manufactured by Nikko Chemicals Co., Ltd.) were added thereto, followed by heating and mixing to form a silk powder (Silkgen G). Powder: 1 g of Ichimaru Pacos Co., Ltd.) dispersed in 3 g of squalane was added, and heated to 80 ° C. as an oil phase. An oil phase was added to the aqueous phase, stirred and mixed at 80 ° C, emulsified, and cooled to 30 ° C or less to prepare a cream.

[Examples 2 and 3]

In Example 1, what mix | blended water instead of the alga colloid was made into Example 2 and Example 3 which mix | blended water instead of sodium hyaluronate, and the cream was prepared.

Comparative Example 1

A cream was prepared in Comparative Example 1, in which water was added instead of the silk powder in Example 1.

Comparative Example 2-4

In Example 1, a cream agent was prepared according to Comparative Example 2, Comparative Example 3, or Comparative Example 4, in which water was mixed instead of two components of alga colloid, hyaluronic acid, and silk powder.

[Test Example]

Usability was evaluated about the cream agent manufactured in Examples 1-3 and Comparative Examples 1-4. Evaluation of the usability was carried out by ten panelists, the use test was carried out, evaluation was carried out based on the following criteria for smoothness, and the average score was determined. In addition, as mentioned above, smoothness is considered to be correlated with the viscosity after thinning and drying the emulsion composition of this invention from the point which concerns on the friction feeling which the finger to apply or the skin of an application part feels at the time of application | coating. Therefore, the smoothness at the time of use of the emulsion composition of this invention was evaluated by measuring the viscosity at the time of drying. Specifically, with respect to the creams prepared in Examples 1 to 3 and Comparative Examples 1 and 2, using a rheometer (AR-1000N), 1 g of the sample was uniformly placed on a circular flat plate and a sample bed having a diameter of 4 cm. After spreading and drying for 5 minutes with a dryer, it evaluated by measuring the viscosity in measurement temperature 25 degreeC and a shear stress of 500 kPa.

Judgment criteria

Smoothness: After apply | coating this external preparation composition to skin of a back of a hand, and fully flattening, the friction feeling at the time of rubbing an application part with the other finger was evaluated.

[Evaluation standard]

5 points | pieces: Very good (I do not recognize a sense of friction, and a finger moves smoothly.)

4 points: Good (almost no sense of friction)

3 points: normal (a slight friction is recognized).

2 points | piece: Poor (recognizes a sense of friction.)

1 point | piece: Very bad (a strong sense of friction and a finger are caught)

[Judgment]

◎: average score 4.5 or more

○: average score 3.5 or more and less than 4.5

△: average score 2.5 or more and less than 3.5

×: average score less than 2.5

The test results are shown in Table 1 below.

Smoothness in the use of the cream of Comparative Example 1 containing algacolloid and hyaluronic acid, Comparative Example 2 containing only silk powder, Comparative Example 3 containing only hyaluronic acid, and Comparative Example 4 containing only algocolloid are moderate to poor The smoothness at the time of using the cream agent of Example 2 containing hyaluronic acid and a silk powder, and Example 3 containing an algal colloid and a silk powder was favorable. Moreover, the smoothness at the time of using the cream agent of Example 1 containing an algal colloid, hyaluronic acid, and silk powder was especially favorable.

In addition, the viscosity at the time of drying in the cream agent of the comparative example 1 containing only alga colloid and hyaluronic acid, and the comparative example 2 containing only silk powder is 3.085 and 9.897, respectively, and the alga colloid, hyaluronic acid, and silk powder are The viscosity at the time of drying in the cream of Example 1 containing Example 1, Example 2 containing hyaluronic acid and silk powder, and Example 3 containing alga colloid and silk powder was low as 1.263, 2.008, and 1.472, respectively, It was clear that the viscosity afterward was low, that is, smoothness was good.

From these points, it became clear that the smoothness at the time of use of the emulsion composition of this invention is favorable, and the smoothness at the time of use is remarkably improved by mix | blending a silk powder with the emulsion composition containing an alga colloid or hyaluronic acid. In particular, it became clear that the emulsion composition of this invention containing an algal colloid, hyaluronic acid, and silk powder has very favorable smoothness at the time of use.

Example 4

Alg colloid (alge colloid: BOTTGER Co., Ltd.) 0.1 g, sodium hyaluronate (sodium hyaluronate HA12: Shiseido Co., Ltd.) 0.05 g, concentrated glycerin 1 g, 1,3-butylene glycol 2 g, carboxyvinyl polymer (Carbopol ETD2050 : 0.15g of Noveon) and 0.27g of potassium hydroxide were added to purified water, and what heated at 80 degreeC was made into the water phase. On the other hand, 2 g of stearic acid, 2 g of acidified oil, 0.4 g of jojoba oil, 0.3 g of cetanol, 2 g of octylate acid octylate and 2 g of glycerol monostearate (Nichol MGS-BMV: manufactured by Nikko Chemicals Co., Ltd.) were added and heated and mixed. After disperse | distributing, the thing which disperse | distributed 1 g of silk powders (Silkgen G powder: Ichimaru Pacos Co., Ltd.) to 2 g of squalene was added, and what heated at 80 degreeC was made into the oil phase. The oil phase was added to the water phase, stirred and mixed at 80 ° C, emulsified, and cooled to 30 ° C or lower to prepare an emulsion. Evaluation of the usability of the obtained emulsion was performed similarly to the above-mentioned test example by the use test by ten panelists. The results are shown in Table 2 below.

It was evident that the emulsion of Example 4 containing algocolloid, hyaluronic acid and silk powder had a smooth feeling of use.

Example 5

0.5 g of hydrogenated soybean phospholipid (PHOSPHOLIPON 90H manufactured by H. Holstein & Co.) was added to 5 g of 1,3-butylene glycol, dissolved at 65 ° C., cooled to 30 ° C., and made into an oil phase. On the other hand, 0.1 g of alga colloids (alge colloid: BOTTGER company), sodium hyaluronate (sodium hyaluronate HA12: Shiseido) 0.05 g, silk powder (Silkgen G powder: Ichimaru Pacos) 0.5 g, carboxy 0.1 g of vinyl polymer (Syntaren L: manufactured by Wako Pure Chemical Industries, Ltd.), 3 g of concentrated glycerin, and 0.044 g of potassium hydroxide were added to purified water, and the mixture was stirred at room temperature to obtain an aqueous phase. The aqueous phase was added to the oil phase, and stirred and mixed at 30 ° C to prepare a lotion. Evaluation of the usability of the obtained lotion was performed similarly to the above-mentioned test example by the use test by ten panelists. The results are shown in Table 3 below.

It was evident that the lotion of Example 5 containing algocolloid, hyaluronic acid and silk powder had a smooth feeling of use.

The present invention provides an emulsified composition containing algocolloid and / or hyaluronic acid and having a smooth feeling. The emulsified composition of the present invention can be used in the cosmetics industry, for example, as an external cosmetic for skin, and can be used in the pharmaceutical industry as a therapeutic agent for dry skin diseases, and has industrial applicability.

Claims (4)

Emulsifying composition containing algocolloid and / or hyaluronic acid, and silk powder. The emulsion composition according to claim 1, which contains algocolloid, hyaluronic acid and silk powder. The emulsion composition according to claim 1 or 2, which is an oil-in-water emulsion composition. The emulsion composition according to any one of claims 1 to 3, which is an external preparation for skin.