CN101389308A - Emulsion composition - Google Patents
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- CN101389308A CN101389308A CNA200780006732XA CN200780006732A CN101389308A CN 101389308 A CN101389308 A CN 101389308A CN A200780006732X A CNA200780006732X A CN A200780006732XA CN 200780006732 A CN200780006732 A CN 200780006732A CN 101389308 A CN101389308 A CN 101389308A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
Disclosed is an emulsion composition comprising algecolloid or hyaluronic acid (preferably both of algecolloid and hyaluronic acid) and a silk powder. The emulsion composition shows a smooth feeling upon use when used as a preparation for external application to the skin.
Description
Technical field
(ア Le ゲ コ ロ イ De algecolloid) and/or hyaluronic acid and have the emulsification composition of smooth usability, particularly relates to the emulsification composition that is applicable to skin preparations for extenal use to the present invention relates to contain alginate jelly.
Background technology
Alginate jelly, hyaluronic acid all are known compositions with excellent moisture-keeping function and blood circulation promoting effect, are widely used compositions in cosmetics etc.Alginate jelly is by the natural component that extracts in the Brown algae, with as the β-1 by D-mannuronic acid (acid of D-マ Application ノ ウ ロ Application), and the alginic acid of the polysaccharide that the 4-key constitutes is main constituent.Known, alginate jelly also has the skin Caring effect except having excellent moisture-keeping function.Hyaluronic acid is that material, molecular weight with repetitive structure of the disaccharide that the beta-glucosidase key of glucuronic acid and N-acetyl group glucamine constitutes reach millions of macromolecular compounds.Therefore hyaluronic acid has very high hydration energy owing to have very long acidic sugar chain.
Is the cosmetics for skin (patent documentation 1) of feature as what contain simultaneously that alginate jelly and hyaluronic cosmetics for example can enumerate the plant extract of (A) Lythraceae (Lythraceae) Lagerstroemia (Lagerstroemia L.), (B) brown alga extract (alginate jelly) etc. more than a kind with the physiologically active ingredient that contains wetting agents such as being selected from whitening agent, antioxidant, antiinflammatory, ultraviolet screening agent, hyaluronic acid, cell vitalizing agent, blood circulation accelerant.But, in containing alginate jelly and hyaluronic emulsification composition, have the shortcoming that lacks smooth feeling, usability difference when using.
The silk powder is the water-insoluble protein powder from the formation thin,tough silk fiber of the cocoon acquisition of silkworm.The effect of silk powder is known ultra-violet absorption effect, antibacterial action and a fungi-proofing effect etc.
Patent documentation 1: TOHKEMY 2005-139070 communique
Summary of the invention
The technical problem that invention will solve
Technical problem of the present invention is to provide the emulsification composition that contains alginate jelly and/or hyaluronic acid, has smooth usability.
The method that is used for the technical solution problem
The inventor furthers investigate in order to solve the problems of the technologies described above, and found that by cooperate the silk powder of powder in containing alginate jelly and/or hyaluronic emulsification composition, can improve the smooth feeling when using, and then has finished following the present invention.
(1) contain alginate jelly and/or hyaluronic acid and the silk powder emulsification composition.
(2) above-mentioned (1) described emulsification composition, it contains alginate jelly, hyaluronic acid and silk powder.
(3) above-mentioned (1) or (2) described emulsification composition, it is an O/W emulsion composition.
(4) each described emulsification composition of above-mentioned (1)～(3), it is a skin preparations for extenal use.
The effect of invention
By in containing alginate jelly and/or hyaluronic emulsification composition, cooperating a silk powder, can improve the slickness when using as skin preparations for extenal use.In addition, by in being combined with alginate jelly and hyaluronic emulsification composition, cooperating the silk powder, the slickness in the time of can further improving the emulsification composition use.
The specific embodiment
Emulsification composition of the present invention contains one of alginate jelly and hyaluronic acid or both and silk powder.Emulsification composition of the present invention preferably contain alginate jelly and hyaluronic both.
Among the present invention, the smooth feeling during use is meant when emulsification composition is applied in skin not have the friction sense that finger of smearing or the skin of smearing the position are felt.This usability can also be by rheological behavior evaluations such as viscosity generally except judging panel's sensory evaluation.
Among the present invention, alginate jelly is the natural component that extracts from Brown algae, is main constituent with the alginic acid.Alginic acid is the β-1 of D-mannuronic acid, the polysaccharide that the 4-key constitutes.For example can enumerate alginate jelly (BOTTGER corporate system), alginate jelly-S (BOTTGER corporate system) as alginate jelly.
The alginate jelly use level is not particularly limited, with respect to the emulsification composition total amount be preferably 0.001～5 weight %, more preferably 0.005～2 weight %, be preferably 0.01～1 weight % especially.
Among the present invention, hyaluronic acid be meant the repetitive structure of the disaccharide that beta-glucosidase key with glucuronic acid and N-acetyl group glucamine constitutes material, be that molecular weight reaches millions of macromolecular compound and salt thereof.The hyaluronic molecular weight that uses among the present invention is not particularly limited, and is preferably 10,000～5,000,000, is preferably 100,000～2,000,000 especially.Hyaluronic acid can be a salt, can enumerate metallic salts such as sodium salt, potassium salt, lithium salts, magnesium salt, calcium salt as hyaluronic salt, alkaline amino acid salts such as lysinate, arginine salt, histidine salt, organic salts such as ammonium salt, triethanolamine salt, diisopropanol amine salt, special preferably clear matter acid sodium.As this hyaluronic acid, for example can enumerate biological hyaluronate sodium HA12 (Shiseido corporate system) etc.
The hyaluronic acid use level is not particularly limited, with respect to the emulsification composition total amount be preferably 0.001～5 weight %, more preferably 0.005～2 weight %, be preferably 0.01～1 weight % especially.
Among the present invention, the silk powder is meant from the water-insoluble proteinic powder of the formation thin,tough silk fiber of the cocoon acquisition of silkworm, is main constituent with the fibroin.The silk powder for example can be enumerated シ Le Network ゲ Application G パ ウ ダ-(-ball Off ア Le コ ス corporate system), シ Le Network ID パ ウ ダ-K-50 (bright dipping petrochemistry corporate system) etc. as commercially available product.In addition, the present invention mention the silk powder can also be that the material that Ornaments has various additional effect is repaiied on the surface.For example can enumerate シ Le Network ID パ ウ ダ-A-705 (bright dipping petrochemistry corporate system), シ Le Network ID パ ウ ダ-S-702 (bright dipping petrochemistry corporate system), シ Le Network ID パ ウ ダ-L-710 (bright dipping petrochemistry corporate system) etc. as commercially available product.
Silk powder use level is not particularly limited, with respect to the emulsification composition total amount be preferably 0.001～5 weight %, more preferably 0.01～2 weight %, be preferably 0.1～1 weight % especially.
In the emulsification composition of the present invention, alginate jelly is not particularly limited with the relative ratios of the use level of silk powder, from the viewpoint of usabilities such as smooth feeling, when the use level that makes a powder was 1, alginate jelly was preferably 0.005～100, more preferably 0.01～10, is preferably 0.02～1 especially.In addition, hyaluronic acid also is not particularly limited with the relative ratios of the use level of silk powder, but from the viewpoint of usabilities such as smooth feeling, when the use level that makes a powder was 1, hyaluronic acid was preferably 0.002～50, more preferably 0.005～5, is preferably 0.01～0.5 especially.Emulsification composition of the present invention is when containing alginate jelly and hyaluronic acid, and is also same as described above with the preferred relative ratios of the use level of silk powder separately.
Among the present invention, the emulsifying form of emulsification composition and O/W emulsion composition and water-in-oil emulsion composition are irrelevant, in addition, can also be applicable to multilamellar emulsification compositions such as W/O/W type emulsification composition, Water-In-Oil oil-in emulsification composition, but from the dry and comfortable viewpoint that waits usability, preferred especially O/W emulsion composition.In addition, comparing of moisture and oil content is not particularly limited in the emulsifier combination of the present invention, from the dry and comfortable preferred moisture of viewpoint that waits usability: oil content=2:1～100:1, preferred especially moisture: oil content=4:1～50:1.
Among the present invention, can enumerate American Avocado Tree oil as oil content, macadimia nut oil, Semen Maydis oil, olive oil, Oleum Brassicae campestris, Radix Oenotherae erythrosepalae oil, Oleum Ricini, Oleum Helianthi, Oleum Camelliae, the Flos Camelliae Japonicae caul-fat, Testa oryzae oil, Jojoba oil, cocoa butter, Oleum Cocois, stearic acid, spermol, 1, the 3-butanediol, Squalene, squalane, Adeps Bovis seu Bubali, haze tallow, Cera Flava, little tree candle wax, Brazil wax, spermaceti, lanoline, liquid paraffin, polyoxyethylene (8 moles) oleyl alcohol ether, glyceryl monooleate, myristic acid octyl group dodecyl ester, Cyclomethicone, dimethyl polysiloxane, diphenyl polysiloxanes etc., preferred especially Flos Camelliae Japonicae caul-fat, Jojoba oil, squalane, stearic acid, spermol, myristic acid octyl group dodecyl ester, 1,3 butylene glycol.In addition, the use level of oil content with respect to the emulsification composition total amount be preferably 0.5～40 weight %, more preferably 2～30 weight %, be preferably 3～20 weight % especially.By making the oil content use level in the emulsification composition is above-mentioned scope, the composite inhibiting sense of being clamminess in use.
The emulsifying agent that uses among the present invention is so long as can be used for skin preparations for extenal use; then be not particularly limited; for example can enumerate alkyl sulfate; the acyl amino hydrochlorate; anion surfactants such as soap; polyoxyalkylene alkyl; the polyoxyalkylene fatty acid ester; the polyoxyalkylene polyol fatty acid ester; polyol fatty acid ester; non-ionic surface active agents such as sucrose fatty acid ester; cationic surfactants such as tetraalkylammonium salt; betaine type; the thetine type; the sulfo-amino acid type; the imidazole salts type; lecithin; amphoteric surfactantes such as LYSOLECITHIN SUNLECITHIN A, preferred especially glyceryl monostearate; hydrogenated soya phosphatide.
In the emulsification composition of the present invention, can also further cooperate whitening composition, anti-inflammatory component, antioxidant content, viscosifier, preservative agent, stabilization agent, wetting agent, pH regulator agent, spice etc.
Whitening composition can be enumerated ascorbic acid and derivant and their salt, the vitamin A or derivatives thereof, the pantothenic acid or derivatives thereof, hydroquinone and derivants thereof such as arbutin, ellagic acid Mandatory acid, resorcinol and derivants thereof such as resveratrol, Flos Matricariae chamomillae extract (Chamomile ET), cysteine and derivant thereof with and salt, glabridin, glabrene., liquiritin, isoliquiritin, rice bran acid and derivant thereof and their salt, caffeic acid and derivant thereof and their salt etc.In the extract, can enumerate Periostracum Cicadae extract, intacellin, Radix Glycyrrhizae extract, Hemerocallis citrina Baroni chrysanthemum extract, the animals and plants extract that contains carotenoids, Germinatus Phragmitis extract, Semen Pisi sativi extract, Arctostaphylos ura-ursi extract, the Radix Scutellariae extract, the ononis spinosa extract, the Fructus Rubi corchorifolii Immaturus extract, Radix Sophorae Flavescentis extract, the Mucuna birdwoodiana extract, Cortex Acanthopancis extract, coffee-extract, the Testa oryzae extract, wheat malt germ extract, Herba Asari extract, Fructus Crataegi extract, senna extract, white Bulbus Lilii extract, Radix Paeoniae Alba extract, Flos Inulae extract, soybean extract, tea extract, the molasses extract, Fructus Lycopersici esculenti extract, the white lotus extract, beechy bud extract, Fructus Vitis viniferae extract, Off ロ-デ マ ニ- extract, Flos lupuli (Flos Humuli Lupuli) extract, the rose extract, Fructus Chaenomelis extract, the hydrangea extract, eucalyptus extracts, Semen Coicis extract and Fructus Momordicae extract etc.
Anti-inflammatory component can be enumerated allantoin, Calamina, glycyrrhizic acid or derivatives thereof, glycyrrhetinic acid or derivatives thereof, zinc oxide, guaiazulene, tocopheryl acetate, vitamin B6, Mentholum, Camphora, Oleum Terebinthinae, indomethacin, salicylic acid or derivatives thereof etc.
Antioxidant content can be enumerated tocopherol and derivant, Butylated hydroxyanisole, two butylated hydroxytoluene, sodium sulfite, arabo-ascorbic acid and salt thereof, flavonoid, glutathion, glutathion peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiolaurine, hypotaurine etc.
Viscosifier can be enumerated sodium carboxymethyl cellulose, carboxy vinyl polymer, hydroxyethyl-cellulose, carrageenan, xanthan gum, sodium polyacrylate, polyvinyl alcohol, locust bean gum, guar gum, gelatin, hydroxypropyl methylcellulose etc.
Preservative agent can be enumerated parabens, benzalkonium chloride etc.
Stabilization agent can be enumerated sodium sulfite, sodium sulfite, two butylated hydroxytoluene, Butylated hydroxyanisole, edetic acid or its esters etc.
Wetting agent can be enumerated polyhydric alcohol such as glycerol, ethylene glycol, propylene glycol, 1,3 butylene glycol, Isopropanediol, Polyethylene Glycol.
The pH regulator agent can be enumerated organic acid such as the mineral acid, citric acid of hydrochloric acid etc., alkali hydroxides such as potassium hydroxide, sodium hydroxide, amines such as triethanolamine, diethanolamine, diisopropanolamine (DIPA).
Spice can be enumerated Oleum Menthae Rotundifoliae, Oleum menthae, linalool, wintergreen oil, Sassafras oil, Oleum Caryophylli, Oleum menthae, thyme oil, Salvia Sclare L.oil, Eucalyptus oil, Herba Lysimachiae foenum-graeci quintessence oil, Majorana hortensis oil, Oleum Cinnamomi, lime oil, Fructus Citri Limoniae oil and Fructus Citri junoris wet goods natural perfume material and L-Mentholum, DL-Camphora etc.
The dosage form of emulsification composition of the present invention is not particularly limited, and can enumerate emulsifiable paste (cream) agent, emulsion agent, Emulsion, emulsified ointment etc., preferred especially ointment, emulsion agent and Emulsion.
Emulsification composition of the present invention can followingly be made: neccessary compositions such as emulsifying agent are blended in water or the oil phase, carry out heating for dissolving in case of necessity after, water, oil phase are mixed, carry out emulsifying, thereby make.Emulsification method used among the present invention can adopt general emulsification method, can use colloid mill, refiner, high pressure homogenizer, ultrasonic emulsification machine etc. to carry out emulsifying.
Emulsification composition of the present invention is because its smooth feeling when using, moistening effect etc., for example can be suitable as the external preparation for skin cosmetics or with respect to the skin preparations for extenal use such as therapeutic agent of drying property dermatosis to use, but the present invention is not limited thereto.Use amount, the frequency of utilization of emulsification composition of the present invention are not particularly limited, and can suitably select according to application target.
Embodiment
Specifically describe the present invention by the following examples, but the present invention is not limited to these.
[embodiment 1]
(ア Le ゲ コ ロ イ De: the BOTTGER corporate system) (biological hyaluronate sodium HA12: the Shiseido corporate system) 0.05g, concentrated glycerin 1g, carboxy vinyl polymer (カ-ボ Port-Le Ultrez10.Noveon corporate system) 0.3g and potassium hydroxide 0.25g are added among the Purified Water 85.7g for 0.1g, hyaluronate sodium with alginate jelly, be heated to 80 ℃, make water.On the other hand, add stearic acid 3g, Flos Camelliae Japonicae caul-fat 4g, Jojoba oil 0.4g, spermol 0.2g and glyceryl monostearate (two Star コ-Le MGS-BMV: after daylight ケ ミ カ Le ズ corporate system) 1g mixes its heating, be added in be dispersed with in the 3g squalane 1g silk powder (シ Le Network ゲ Application G パ ウ ダ-: material-ball Off ア Le コ ス corporate system), be heated to 80 ℃, make oil phase.Add oil phase at aqueous phase, under 80 ℃, mix, carry out emulsifying after, be cooled to below 30 ℃, make ointment.
[embodiment 2,3]
In embodiment 1, replacement alginate jelly hydrous water person as embodiment 3, makes ointment as embodiment 2, replacement hyaluronate sodium hydrous water person.
[comparative example 1]
In embodiment 1, replace silk powder hydrous water person as a comparative example 1, make ointment.
[comparative example 2～4]
In embodiment 1, with replace in alginate jelly, hyaluronic acid, the silk powder 2 components matching water persons as a comparative example 2, comparative example 3, comparative example 4, make ointment.
[test example]
Ointment for embodiment 1～3 and comparative example 1～4 manufacturing carries out the evaluation of usability.The evaluation of usability is carried out service test by 10 judging panels, estimates according to following standard for smooth feeling, judges with its average mark.In addition, as mentioned above, smooth feeling is because the friction sense that the skin of finger of smearing when smearing or spreader portion is felt is relevant, therefore thinks to make its dried viscosity relevant with emulsification composition of the present invention is extended thinly.Thereby the viscosity when measuring drying is estimated emulsification composition of the present invention smooth feeling in use.Specifically, for the ointment of embodiment 1～3 and comparative example 1～2 manufacturing, use flow graph (AR-1000N), sample 1g is extended equably on the circular dull and stereotyped and sample bench of diameter 4cm, utilize exsiccator after dry 5 minutes, thereby estimate in 25 ℃ of viscosity of measuring down under the shear stress 500Pa of mensuration temperature.
[criterion]
Smooth feeling: with this preparation composition for external use spread upon on the back of the hand portion skin fully extend after, the friction sense when estimating the finger friction spreader portion with the another hands.
[evaluation criterion]
5 minutes: very good (not friction sense, finger moved swimmingly.)
4 minutes: good (not friction sense substantially.)
3 minutes: common (had the friction sense slightly.)
2 minutes: bad (had the friction sense.)
1 minute: very bad (sense of feeling strongly to rub, finger were obstructed.)
[judgement]
◎: average mark is more than 4.5
Zero: average mark is more than 3.5, less than 4.5
△: average mark is more than 2.5, less than 3.5
*: average mark is less than 2.5
Result of the test is shown in table 1.
Table 1
Contain alginate jelly and hyaluronic comparative example 1, only contain the comparative example 2 of a powder, only contain hyaluronic comparative example 3, only to contain the ointment smooth feeling in use of comparative example 4 of alginate jelly common or bad, contain relatively therewith hyaluronic acid and silk powder embodiment 2, contain alginate jelly and silk powder the ointment smooth feeling in use of embodiment 3 good.In addition, it is good especially to contain the ointment smooth feeling in use of embodiment 1 of alginate jelly, hyaluronic acid and silk powder.
In addition, with respect to containing alginate jelly and hyaluronic comparative example 1, only containing the viscosity of ointment when the drying of comparative example 2 of a powder respectively up to 3.085,9.897, contain the embodiment 1 of alginate jelly, hyaluronic acid and silk powder, the embodiment 2 that contains hyaluronic acid and silk powder therewith relatively, the viscosity of ointment when drying that contains the embodiment 3 of alginate jelly and silk powder is low to moderate 1.263,2.008,1.472 respectively, the viscosity after smearing as can be known is low, be that smooth feeling is good.
From the above, emulsification composition of the present invention smooth feeling in use is good, and by containing an alginate jelly or hyaluronic emulsification composition cooperation silk powder, the smooth feeling during use significantly improves.Particularly, it is very good to contain the emulsification composition of the present invention smooth feeling in use of alginate jelly, hyaluronic acid and silk powder.
[embodiment 4]
With alginate jelly (alginate jelly: the BOTTGER corporate system) 0.1g, hyaluronate sodium (biological hyaluronate sodium HA12: the Shiseido corporate system) 0.05g, concentrated glycerin 1g, 1,3-butanediol 2g, carboxy vinyl polymer (カ-ボ Port-Le ETD2050:Noveon corporate system) 0.15g and potassium hydroxide 0.27g add in the Purified Water, be heated to 80 ℃, make water.On the other hand, add stearic acid 2g, Flos Camelliae Japonicae caul-fat 2g, Jojoba oil 0.4g, spermol 0.3g, myristic acid octyl group dodecyl ester 2g and glyceryl monostearate (ニ Star コ-Le MGS-BMV: daylight ケ ミ カ Le ズ corporate system) 0.3g, after heating mixes, be added in be dispersed with in the 2g squalane powder (シ Le Network ゲ Application G パ ウ ダ-:-ball Off ア Le コ ス corporate system) material of 1g, be heated to 80 ℃, make oil phase.Add oil phase at aqueous phase, under 80 ℃, mix, after the emulsifying, be cooled to below 30 ℃, make emulsion.Service test and above-mentioned test example by 10 judging panels are similarly carried out the usability evaluation of gained emulsion.The results are shown in table 2.
Table 2
| Composition | Embodiment 4 (g) |
| Algin Sodium Hyaluronate silk powder concentrated glycerin 1.3-butanediol carboxy vinyl polymer potassium hydroxide stearic acid behenic Camellia oil Jojoba Oil cetanol myristic acid octyl group dodecyl ester glycerin monostearate saualane Purified Water | 0.1 0.05 1.0 1.0 2.0 0.15 0.27 2.0 2.0 0.4 0.3 2.0 0.3 2.0 total amount 100g |
| (assessment item) smooth feeling | ◎ |
As can be known, the emulsion that contains the embodiment 4 of alginate jelly, hyaluronic acid and silk powder has slick usability.
[embodiment 5]
(PHOSPHOLIPON9OH: エ イ チ ホ Le ス イ Application ア Application De カ Application パ ニ-corporate system) 0.5g adds among the 1,3 butylene glycol 5g, at 65 ℃ of dissolving postcooling to 30 ℃ down, makes oil phase with hydrogenated soya phosphatide.On the other hand, with alginate jelly (ア Le ゲ コ ロ イ De: the BOTTGER corporate system) 0.1g, hyaluronate sodium (biological hyaluronate sodium HA12: the Shiseido corporate system) 0.05g, silk powder (シ Le Network ゲ Application G パ ウ ダ-:-ball Off ア Le コ ス corporate system) 0.5g, carboxy vinyl polymer (シ Application レ Application L: and light Pure
Corporate system) 0.1g, concentrated glycerin 3g and potassium hydroxide 0.044g add in the Purified Water, at room temperature stir, and make water.In oil phase, add water, under 30 ℃, mix, make emulsion.Service test and above-mentioned test example by 10 judging panels are similarly carried out the usability evaluation of gained emulsion.The results are shown in table 3.
Table 3
| Composition | Embodiment 5 (g) |
| Alginate jelly hyaluronate sodium silk powder hydrogenated soya phosphatide 1,3 butylene glycol carboxy vinyl polymer concentrated glycerin potassium hydroxide Purified Water | 0.1 0.05 0.5 0.5 5.0 0.10 3.0 0.044 total amount 100g |
| (assessment item) smooth feeling | ◎ |
The emulsion that contains the embodiment 5 of alginate jelly, hyaluronic acid and silk powder has slick usability.
Industrial applicability
The invention provides the emulsification composition that contains algin and/or hyaluronic acid and have smooth use sense. Emulsification composition of the present invention is except can be as utilizing in cosmetic industry such as external preparation for skin cosmetics etc., can also conduct utilizes in pharmaceutical industry for the therapeutic agent of dry skin disease, has utilizing on the industry.
Claims (4)
1. the emulsification composition that contains alginate jelly and/or hyaluronic acid and silk powder.
2. the described emulsification composition of claim 1, it contains alginate jelly, hyaluronic acid and silk powder.
3. claim 1 or 2 described emulsification compositions, it is an O/W emulsion composition.
4. each described emulsification composition of claim 1～3, it is a skin preparations for extenal use.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP052461/2006 | 2006-02-28 | ||
| JP2006052461 | 2006-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101389308A true CN101389308A (en) | 2009-03-18 |
Family
ID=38458872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200780006732XA Pending CN101389308A (en) | 2006-02-28 | 2007-02-09 | Emulsion composition |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPWO2007099757A1 (en) |
| KR (1) | KR20080104027A (en) |
| CN (1) | CN101389308A (en) |
| WO (1) | WO2007099757A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010229107A (en) * | 2009-03-27 | 2010-10-14 | Kose Corp | Cosmetic composition, and skin external preparation or cosmetic which contain the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61204109A (en) * | 1985-03-07 | 1986-09-10 | Eisai Co Ltd | Emulsion-type composition for external use |
| JP2696357B2 (en) * | 1988-09-27 | 1998-01-14 | 株式会社コーセー | Cloudy bath additive |
| JP2002212087A (en) * | 2001-01-22 | 2002-07-31 | Kose Corp | Skin care preparation |
| JP2006111576A (en) * | 2004-10-14 | 2006-04-27 | Medicaraise Corp | Skin care preparation for external use containing mucopolysaccharides and silk peptide |
-
2007
- 2007-02-09 CN CNA200780006732XA patent/CN101389308A/en active Pending
- 2007-02-09 JP JP2008502687A patent/JPWO2007099757A1/en active Pending
- 2007-02-09 WO PCT/JP2007/052370 patent/WO2007099757A1/en active Application Filing
- 2007-02-09 KR KR1020087023441A patent/KR20080104027A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20080104027A (en) | 2008-11-28 |
| JPWO2007099757A1 (en) | 2009-07-16 |
| WO2007099757A1 (en) | 2007-09-07 |
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Open date: 20090318 |