KR20080092412A - 단백질 키나제 억제제로서의 화합물 및 조성물 - Google Patents
단백질 키나제 억제제로서의 화합물 및 조성물 Download PDFInfo
- Publication number
- KR20080092412A KR20080092412A KR1020087019186A KR20087019186A KR20080092412A KR 20080092412 A KR20080092412 A KR 20080092412A KR 1020087019186 A KR1020087019186 A KR 1020087019186A KR 20087019186 A KR20087019186 A KR 20087019186A KR 20080092412 A KR20080092412 A KR 20080092412A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- ylamino
- phenyl
- pyrimidin
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CC(C)(C)OC(*)Nc1cc(Nc(ncnc2)c2-c2cc(*=O)ncn2)c(C)cc1 Chemical compound CC(C)(C)OC(*)Nc1cc(Nc(ncnc2)c2-c2cc(*=O)ncn2)c(C)cc1 0.000 description 4
- AWLFLCICLMRDLQ-UHFFFAOYSA-N CC(C)(C)OC(Nc1ccc(C)c(Nc2ncccc2C2=CC(NCc(c(OC)c3)ccc3OC)NC=N2)c1)=O Chemical compound CC(C)(C)OC(Nc1ccc(C)c(Nc2ncccc2C2=CC(NCc(c(OC)c3)ccc3OC)NC=N2)c1)=O AWLFLCICLMRDLQ-UHFFFAOYSA-N 0.000 description 1
- VFLBKGLOVRRTCW-UHFFFAOYSA-N Clc1ncccc1-c1ncnc(NC2CC2)c1 Chemical compound Clc1ncccc1-c1ncnc(NC2CC2)c1 VFLBKGLOVRRTCW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77104506P | 2006-02-06 | 2006-02-06 | |
| US60/771,045 | 2006-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080092412A true KR20080092412A (ko) | 2008-10-15 |
Family
ID=38255301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087019186A Ceased KR20080092412A (ko) | 2006-02-06 | 2007-02-06 | 단백질 키나제 억제제로서의 화합물 및 조성물 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090069327A1 (https=) |
| EP (1) | EP1981870A2 (https=) |
| JP (1) | JP2009525978A (https=) |
| KR (1) | KR20080092412A (https=) |
| CN (1) | CN101421262A (https=) |
| AU (1) | AU2007212345A1 (https=) |
| BR (1) | BRPI0707666A2 (https=) |
| CA (1) | CA2637225A1 (https=) |
| RU (1) | RU2008135690A (https=) |
| WO (1) | WO2007092531A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200811134A (en) | 2006-07-12 | 2008-03-01 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| EP2307456B1 (en) | 2008-06-27 | 2014-10-15 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| UY32582A (es) * | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| AU2011289661C1 (en) * | 2010-08-07 | 2014-12-04 | The Research Foundation For The State University Of New York | Oral compositions comprising a zinc compound and an anti-microbial agent |
| PL2647637T3 (pl) * | 2010-12-02 | 2016-06-30 | Medpacto Inc | Pochodna purynylopirydynyloamino-2,4-dlfluorofenylo-sulfonamidu, jej farmaceutycznie dopuszczalna sól, sposób jej wytwarzania oraz zawierająca ją jako składnik aktywny kompozycja farmaceutyczna o aktywności hamującej kinazę Raf |
| US9834518B2 (en) | 2011-05-04 | 2017-12-05 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| KR20180084153A (ko) * | 2011-06-10 | 2018-07-24 | 메르크 파텐트 게엠베하 | Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물의 조성물 및 제조방법 |
| US9061028B2 (en) * | 2012-02-15 | 2015-06-23 | Natco Pharma Limited | Process for the preparation of Nilotinib |
| US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| CA3015417A1 (en) | 2016-03-01 | 2017-09-08 | Propellon Therapeutics Inc. | Inhibitors of wdr5 protein-protein binding |
| JP7624690B2 (ja) | 2016-03-01 | 2025-01-31 | プロペロン セラピューティクス インコーポレイテッド | Ｗｄｒ５タンパク質－タンパク質結合の阻害剤 |
| EP3848370B1 (en) * | 2016-10-14 | 2025-05-07 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors and uses thereof |
| WO2020056132A1 (en) * | 2018-09-13 | 2020-03-19 | University Of Southern California | Novel fgfr inhibitors and uses thereof |
| KR102878873B1 (ko) * | 2019-02-14 | 2025-10-31 | 브리진 바이오사이언시스, 인코포레이티드 | 암 치료를 위한 fgfr 억제제 |
| AU2021358123A1 (en) | 2020-10-05 | 2023-06-08 | Enliven Inc. | 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases |
| CN117222640A (zh) * | 2021-04-03 | 2023-12-12 | 先声再明医药有限公司 | 作为fgfr抑制剂的杂环化合物及其应用 |
| WO2024159094A1 (en) * | 2023-01-27 | 2024-08-02 | Enliven Inc. | Pyrimidinyl (hetero)aromatic aminopyridine compounds for inhibition of raf kinases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004278413B2 (en) * | 2003-09-30 | 2008-07-31 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| EP1751136B1 (en) * | 2004-05-07 | 2014-07-02 | Amgen Inc. | Nitrogenated heterocyclic derivatives as protein kinase modulators and use for the treatment of angiogenesis and cancer |
-
2007
- 2007-02-06 JP JP2008553429A patent/JP2009525978A/ja active Pending
- 2007-02-06 EP EP07717222A patent/EP1981870A2/en not_active Withdrawn
- 2007-02-06 KR KR1020087019186A patent/KR20080092412A/ko not_active Ceased
- 2007-02-06 AU AU2007212345A patent/AU2007212345A1/en not_active Abandoned
- 2007-02-06 CN CNA2007800046499A patent/CN101421262A/zh active Pending
- 2007-02-06 RU RU2008135690/04A patent/RU2008135690A/ru not_active Application Discontinuation
- 2007-02-06 BR BRPI0707666-5A patent/BRPI0707666A2/pt not_active IP Right Cessation
- 2007-02-06 CA CA002637225A patent/CA2637225A1/en not_active Abandoned
- 2007-02-06 WO PCT/US2007/003319 patent/WO2007092531A2/en not_active Ceased
- 2007-02-06 US US12/162,313 patent/US20090069327A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007092531A3 (en) | 2007-10-18 |
| JP2009525978A (ja) | 2009-07-16 |
| US20090069327A1 (en) | 2009-03-12 |
| WO2007092531A2 (en) | 2007-08-16 |
| CA2637225A1 (en) | 2007-08-16 |
| EP1981870A2 (en) | 2008-10-22 |
| AU2007212345A1 (en) | 2007-08-16 |
| BRPI0707666A2 (pt) | 2011-05-10 |
| RU2008135690A (ru) | 2010-03-20 |
| CN101421262A (zh) | 2009-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| PA0105 | International application |
Patent event date: 20080805 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20080805 Comment text: Request for Examination of Application |
|
| PG1501 | Laying open of application | ||
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20100716 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20101005 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20100716 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |