KR20080091832A - 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 - Google Patents

중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 Download PDF

Info

Publication number
KR20080091832A
KR20080091832A KR1020087021183A KR20087021183A KR20080091832A KR 20080091832 A KR20080091832 A KR 20080091832A KR 1020087021183 A KR1020087021183 A KR 1020087021183A KR 20087021183 A KR20087021183 A KR 20087021183A KR 20080091832 A KR20080091832 A KR 20080091832A
Authority
KR
South Korea
Prior art keywords
self
cells
asc
cell
organizing mesenchymal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020087021183A
Other languages
English (en)
Korean (ko)
Inventor
모쉐 크후르겔
아담 제이. 카츠
Original Assignee
유니버시티 오브 버지니아 페이턴트 파운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 유니버시티 오브 버지니아 페이턴트 파운데이션 filed Critical 유니버시티 오브 버지니아 페이턴트 파운데이션
Publication of KR20080091832A publication Critical patent/KR20080091832A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
KR1020087021183A 2006-01-30 2007-01-30 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도 Withdrawn KR20080091832A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76333306P 2006-01-30 2006-01-30
US60/763,333 2006-01-30

Publications (1)

Publication Number Publication Date
KR20080091832A true KR20080091832A (ko) 2008-10-14

Family

ID=38328013

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087021183A Withdrawn KR20080091832A (ko) 2006-01-30 2007-01-30 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도

Country Status (7)

Country Link
US (1) US8592209B2 (cg-RX-API-DMAC7.html)
EP (1) EP1984488B1 (cg-RX-API-DMAC7.html)
JP (1) JP2009525044A (cg-RX-API-DMAC7.html)
KR (1) KR20080091832A (cg-RX-API-DMAC7.html)
AU (1) AU2007209870A1 (cg-RX-API-DMAC7.html)
CA (1) CA2641022A1 (cg-RX-API-DMAC7.html)
WO (1) WO2007089798A2 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101490235B1 (ko) * 2011-05-31 2015-02-05 서울대학교산학협력단 조직 재생용 구조체 및 이의 제조 방법
WO2015199416A1 (ko) * 2014-06-23 2015-12-30 단국대학교 천안캠퍼스 산학협력단 피부 또는 혈관 조직 손상 치료용 약학 조성물 및 이의 이용

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100322906A1 (en) 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
KR20080091832A (ko) 2006-01-30 2008-10-14 유니버시티 오브 버지니아 페이턴트 파운데이션 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도
AU2007320031B2 (en) 2006-10-06 2013-05-02 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
US20120100607A1 (en) * 2007-07-12 2012-04-26 Christopher Duntsch Compositions of adult disc stem cells and methods for the treatment of degenerative disc disease
US10633632B2 (en) * 2007-07-12 2020-04-28 Discgenics, Inc. Human disc tissue
US8227246B2 (en) 2007-07-12 2012-07-24 Discgenics Compositions of adult disc stem cells for the treatment of degenerative disc disease
CN101755046B (zh) 2007-07-20 2012-08-08 东国大学校产学协力团 采用间充质干细胞制备真皮乳头组织的方法
SG187493A1 (en) * 2008-01-18 2013-02-28 Univ Minnesota Stem cell aggregates and methods for making and using
US20110059182A1 (en) * 2008-02-05 2011-03-10 University Of Virginia Patent Foundation Spraying device and related method for cell aggregates and cell aggregate suspension thereof
US20110165128A1 (en) * 2008-03-07 2011-07-07 Columbia University In The City Of New York Homing in mesenchymal stem cells
GB0805670D0 (en) * 2008-03-28 2008-04-30 Smith & Nephew Increasing the plasticity of stem cells
MX2011001730A (es) 2008-08-14 2011-03-24 Osiris Therapeutics Inc Composiciones purificadas de celulas madre mesenquimales y metodos para purificar composiciones de celulas madre mesenquimales.
ES2401640T3 (es) * 2008-09-22 2013-04-23 University Of Zurich Prorektorat Forschung Placa para gotas en suspensión
US20100112031A1 (en) * 2008-10-17 2010-05-06 University Of Virginia Patent Foundation Compositions And Methods For Regulating Extracellular Matrix Production In Adipose Derived Cells
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
WO2010129775A1 (en) 2009-05-06 2010-11-11 University Of Virginia Patent Foundation Self-illuminated handheld lens for retinal examination and photography and related method thereof
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
WO2012027474A1 (en) 2010-08-24 2012-03-01 Regents Of The University Of Minnesota Non-static suspension culture of cell aggregates
WO2012048093A2 (en) 2010-10-08 2012-04-12 Osiris Therapeutics, Inc. Enhanced msc preparations
TWI523947B (zh) * 2010-10-18 2016-03-01 尚翔股份有限公司 人類多能性類胚胎幹細胞先驅細胞
EP2655602B1 (en) * 2010-12-22 2019-01-23 The Administrators of the Tulane Educational Fund Method for identifcation and culture of multipotent mesenchymal stem cells with high proliferation potential
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
EP2726603B1 (en) * 2011-06-29 2020-04-01 Biorestorative Therapies, Inc. Brown fat cell compositions and methods
WO2014033209A1 (en) * 2012-08-29 2014-03-06 Euromi S.A. Apparatus for extracting and re-injecting adipose tissue
ES2859548T3 (es) 2013-04-19 2021-10-04 Biorestorative Therapies Inc Células madre derivadas de tejido adiposo marrón humano y sus usos
WO2015017500A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
SG10201914005TA (en) 2013-09-19 2020-03-30 Univ Leland Stanford Junior Methods and compositions for producing hepatocyte-like cells
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
EP3359553B1 (en) 2015-10-06 2025-03-26 University Of Virginia Patent Foundation Compositions for treating diabetic retinopathy
US20210355199A1 (en) 2018-06-28 2021-11-18 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interaction and signaling
US11541101B1 (en) 2018-10-09 2023-01-03 University Of Virginia Patent Foundation LEMD3 antagonizes TGF-beta-driven Smad2/3 transcription in a stiffness-dependent fashion in both the nucleus and cytosol
US12702683B2 (en) 2019-01-03 2026-08-11 Mesoblast International Sárl Method for improving visual acuity
CN111518751A (zh) * 2019-11-20 2020-08-11 广东先康达生物科技有限公司 一种体外激活脂肪干细胞转化成原软骨细胞的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
AU4543193A (en) 1992-06-22 1994-01-24 Henry E. Young Scar inhibitory factor and use thereof
US5591625A (en) 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
CA2237890C (en) 1995-11-16 2011-03-29 Case Western Reserve University In vitro chondrogenic induction of human mesenchymal stem cells
US6200606B1 (en) 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
RU2306335C2 (ru) 1999-03-10 2007-09-20 Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн Стволовые клетки и решетки, полученные из жировой ткани
US6429013B1 (en) * 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
EP1261694B1 (en) * 2000-02-26 2008-01-16 Artecel, Inc. Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof
DE10013223C2 (de) 2000-03-13 2002-07-18 Co Don Ag Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial
KR20040094910A (ko) 2002-04-03 2004-11-10 아르테셀 사이언스, 인크. 개선된 지방세포 분화된 지방 유래 성체 줄기세포 및 이의용도
JP2004150624A (ja) 2002-09-03 2004-05-27 Seiko Epson Corp 磁気軸受装置
KR100534215B1 (ko) 2003-11-11 2005-12-08 (주)히스토스템 냉동 보관된 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법
WO2005056072A1 (ja) * 2003-12-11 2005-06-23 Japan Science And Technology Agency 擬微小重力環境下での骨髄細胞を用いた3次元軟骨組織構築方法
US20080064034A1 (en) 2004-05-21 2008-03-13 Fraunhofer-Gesellschaft Zur Förderung Der Angewand Multi-Cellular Test Systems
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
WO2006032054A2 (en) 2004-09-14 2006-03-23 The Trustees Of Columbia University In The City Of New York Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair
KR100833612B1 (ko) 2004-12-29 2008-05-30 에프씨비파미셀 주식회사 간엽 간세포로부터 분화된 신경세포를 유효성분으로함유하는 신경계 질환 치료용 약학 조성물
AU2005322873B2 (en) 2004-12-30 2011-09-01 Primegen Biotech, Llc Adipose-derived stem cells for tissue regeneration and wound healing
US20080213235A1 (en) 2005-07-29 2008-09-04 University Of Virginia Patent Foundation Adipose Tissue Stem Cells, Perivascular Cells and Pericytes
WO2007030652A2 (en) 2005-09-08 2007-03-15 University Of Virginia Patent Foundation Methods and compositions for growing adipose stem cells
KR100679642B1 (ko) 2005-11-16 2007-02-06 주식회사 알앤엘바이오 인간 지방조직 유래 다분화능 줄기세포 및 이를 함유하는세포치료제
KR20080091832A (ko) 2006-01-30 2008-10-14 유니버시티 오브 버지니아 페이턴트 파운데이션 중간엽 줄기 세포 응집물의 제조 및 특성화 방법, 및 이의 용도
AU2007320031B2 (en) 2006-10-06 2013-05-02 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
US7787327B2 (en) 2006-11-15 2010-08-31 Baker Hughes Incorporated Cement bond analysis
US20100098739A1 (en) 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101490235B1 (ko) * 2011-05-31 2015-02-05 서울대학교산학협력단 조직 재생용 구조체 및 이의 제조 방법
WO2015199416A1 (ko) * 2014-06-23 2015-12-30 단국대학교 천안캠퍼스 산학협력단 피부 또는 혈관 조직 손상 치료용 약학 조성물 및 이의 이용

Also Published As

Publication number Publication date
JP2009525044A (ja) 2009-07-09
US20090304643A1 (en) 2009-12-10
WO2007089798A3 (en) 2008-03-06
EP1984488A2 (en) 2008-10-29
CA2641022A1 (en) 2007-08-09
WO2007089798A2 (en) 2007-08-09
US8592209B2 (en) 2013-11-26
EP1984488B1 (en) 2017-12-27
AU2007209870A1 (en) 2007-08-09
EP1984488A4 (en) 2009-05-13

Similar Documents

Publication Publication Date Title
EP1984488B1 (en) Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
EP2076275B1 (en) Compositions useful for diabetic wound healing
US7932084B2 (en) Methods and compositions for growing adipose stem cells
ES2535042T3 (es) Identificación y aislamiento de células multipotentes de tejido mesenquimal no osteocondral
Young et al. Human pluripotent and progenitor cells display cell surface cluster differentiation markers CD10, CD13, CD56, and MHC class-I
Caterson et al. Human marrow-derived mesenchymal progenitor cells: isolation, culture expansion, and analysis of differentiation
CN104204193B (zh) 间充质干细胞的培养
KR102124837B1 (ko) 기질 줄기 세포
US20100098739A1 (en) Compositions and methods for modular soft tissue repair
US20080213235A1 (en) Adipose Tissue Stem Cells, Perivascular Cells and Pericytes
PT2626417E (pt) Métodos para expansão celular e usos de células e de meios condicionados produzidos através deles para terapia
CN102803472B (zh) 去除了外来表型的由多能干细胞分化的子代细胞
US20110171726A1 (en) Multipotent stem cells derived from human adipose tissue and cellular therapeutic agents comprising the same
US20220218758A1 (en) Quadri-positive stromal cell (qpsc) population for superior cell protection and immunomodulation
US20160120910A1 (en) Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
Yang et al. Evaluation of human MSCs cell cycle, viability and differentiation in micromass culture
Dimitrov et al. First-trimester human decidua contains a population of mesenchymal stem cells
CN104995295A (zh) 多分化潜能细胞的制造方法
US20220313741A1 (en) Pluripotent stem cells inducing osteochondral repair
Hwang et al. Differentiation of stem cells isolated from rat smooth muscle
WO2025076394A1 (en) Generation of stem cells with high plasticity
Manabe et al. for this novel population, CD34" c-kit" CD140a" Sca

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20080829

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid