KR20070098798A - Ｄｐｄ 억제제를 5-ｆｕ 및 5-ｆｕ 전구약물과 조합한투여방법 - Google Patents

Ｄｐｄ 억제제를 5-ｆｕ 및 5-ｆｕ 전구약물과 조합한투여방법 Download PDF

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Publication number
KR20070098798A
KR20070098798A KR1020077013028A KR20077013028A KR20070098798A KR 20070098798 A KR20070098798 A KR 20070098798A KR 1020077013028 A KR1020077013028 A KR 1020077013028A KR 20077013028 A KR20077013028 A KR 20077013028A KR 20070098798 A KR20070098798 A KR 20070098798A
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KR
South Korea
Prior art keywords
administered
eniluracil
prodrug
dpd inhibitor
dpd
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Ceased
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KR1020077013028A
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English (en)
Korean (ko)
Inventor
톰 스펙터
윌리암 폴 피터스
도날드 윌리암 커프
브라이언 후버
Original Assignee
애드헤렉스 테크놀로지스 인크.
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Publication of KR20070098798A publication Critical patent/KR20070098798A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020077013028A 2004-12-03 2005-12-05 Ｄｐｄ 억제제를 5-ｆｕ 및 5-ｆｕ 전구약물과 조합한투여방법 Ceased KR20070098798A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63303404P 2004-12-03 2004-12-03
US60/633,034 2004-12-03

Publications (1)

Publication Number Publication Date
KR20070098798A true KR20070098798A (ko) 2007-10-05

Family

ID=36087538

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077013028A Ceased KR20070098798A (ko) 2004-12-03 2005-12-05 Ｄｐｄ 억제제를 5-ｆｕ 및 5-ｆｕ 전구약물과 조합한투여방법

Country Status (10)

Country Link
US (2) US8318756B2 (https=)
EP (1) EP1827443A1 (https=)
JP (2) JP2008521930A (https=)
KR (1) KR20070098798A (https=)
CN (2) CN102441170A (https=)
AU (1) AU2005311730B2 (https=)
CA (1) CA2587514A1 (https=)
MX (1) MX2007006646A (https=)
NZ (1) NZ555176A (https=)
WO (1) WO2006060697A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ555176A (en) * 2004-12-03 2010-03-26 Adherex Technologies Inc Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs
WO2009100367A2 (en) * 2008-02-06 2009-08-13 Adherex Technologies Inc. Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome
WO2009118712A2 (en) * 2008-03-27 2009-10-01 Ecole Polytechnique Federale De Lausanne (Epfl) Novel dihydroxypyrrolidine derivatives as anti-cancer agents
CN102648412A (zh) * 2009-07-17 2012-08-22 美瑞德生物工程公司 5-fu的检测方法
CA2777546C (en) * 2009-10-14 2019-11-05 Elion Oncology Llc Treating neurotoxicity associated with combinations of 5-fu or its prodrugs and dpd inhibitors
WO2014089004A1 (en) * 2012-12-04 2014-06-12 Adherex Technologies, Inc. Methods for treating 5-fluorouracil prodrug non-responsive cancer patients
CN106692173A (zh) * 2015-11-18 2017-05-24 北京诺普德医药科技有限公司 一种抗肿瘤复方组合物及其应用
CN106619689B (zh) 2016-12-30 2018-05-01 陈晓华 一种用于治疗癌症的药物组合物、试剂盒及其应用
WO2020125550A1 (zh) * 2018-12-19 2020-06-25 广州君赫生物科技有限公司 化合物在治疗与saicar累积相关的疾病的用途
CN109655606A (zh) * 2019-01-11 2019-04-19 华东师范大学 一种利用3d类器官评价药物肠毒性的检测方法
WO2023283921A1 (zh) * 2021-07-16 2023-01-19 北京深蓝泰医药科技有限公司 Dpd抑制剂及其药物组合物和用途
IL321302A (en) * 2022-12-06 2025-08-01 Elion Oncology Inc Combined use of anilouracil and capecitabine for cancer treatment
WO2025015267A1 (en) * 2023-07-13 2025-01-16 Processa Pharmaceuticals, Inc. Methods of personalizing cancer treatment

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8629892D0 (en) 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US5157114A (en) 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
JP3094036B2 (ja) 1990-07-19 2000-10-03 ザ ウエルカム ファウンデーション リミテッド 酵素不活性化剤
GB9020930D0 (en) 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
IT1255522B (it) * 1992-09-24 1995-11-09 Ubaldo Conte Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita'
US5476855A (en) 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
NZ330360A (en) 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US20040028687A1 (en) * 2002-01-15 2004-02-12 Waelti Ernst Rudolf Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues
NZ555176A (en) * 2004-12-03 2010-03-26 Adherex Technologies Inc Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs

Also Published As

Publication number Publication date
US20060148753A1 (en) 2006-07-06
AU2005311730B2 (en) 2011-11-17
JP2012229273A (ja) 2012-11-22
NZ555176A (en) 2010-03-26
AU2005311730A1 (en) 2006-06-08
EP1827443A1 (en) 2007-09-05
US20130184232A1 (en) 2013-07-18
JP2008521930A (ja) 2008-06-26
CN101068549A (zh) 2007-11-07
MX2007006646A (es) 2007-11-16
WO2006060697A1 (en) 2006-06-08
WO2006060697A9 (en) 2006-09-21
US8318756B2 (en) 2012-11-27
CA2587514A1 (en) 2006-06-08
CN102441170A (zh) 2012-05-09

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