CN102441170A - 与5-fu和5-fu前药组合施用dpd抑制剂的方法 - Google Patents
与5-fu和5-fu前药组合施用dpd抑制剂的方法 Download PDFInfo
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- CN102441170A CN102441170A CN2011104284155A CN201110428415A CN102441170A CN 102441170 A CN102441170 A CN 102441170A CN 2011104284155 A CN2011104284155 A CN 2011104284155A CN 201110428415 A CN201110428415 A CN 201110428415A CN 102441170 A CN102441170 A CN 102441170A
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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| NZ555176A (en) * | 2004-12-03 | 2010-03-26 | Adherex Technologies Inc | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs |
| WO2009100367A2 (en) * | 2008-02-06 | 2009-08-13 | Adherex Technologies Inc. | Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome |
| WO2009118712A2 (en) * | 2008-03-27 | 2009-10-01 | Ecole Polytechnique Federale De Lausanne (Epfl) | Novel dihydroxypyrrolidine derivatives as anti-cancer agents |
| CN102648412A (zh) * | 2009-07-17 | 2012-08-22 | 美瑞德生物工程公司 | 5-fu的检测方法 |
| CA2777546C (en) * | 2009-10-14 | 2019-11-05 | Elion Oncology Llc | Treating neurotoxicity associated with combinations of 5-fu or its prodrugs and dpd inhibitors |
| WO2014089004A1 (en) * | 2012-12-04 | 2014-06-12 | Adherex Technologies, Inc. | Methods for treating 5-fluorouracil prodrug non-responsive cancer patients |
| CN106692173A (zh) * | 2015-11-18 | 2017-05-24 | 北京诺普德医药科技有限公司 | 一种抗肿瘤复方组合物及其应用 |
| CN106619689B (zh) | 2016-12-30 | 2018-05-01 | 陈晓华 | 一种用于治疗癌症的药物组合物、试剂盒及其应用 |
| WO2020125550A1 (zh) * | 2018-12-19 | 2020-06-25 | 广州君赫生物科技有限公司 | 化合物在治疗与saicar累积相关的疾病的用途 |
| CN109655606A (zh) * | 2019-01-11 | 2019-04-19 | 华东师范大学 | 一种利用3d类器官评价药物肠毒性的检测方法 |
| WO2023283921A1 (zh) * | 2021-07-16 | 2023-01-19 | 北京深蓝泰医药科技有限公司 | Dpd抑制剂及其药物组合物和用途 |
| IL321302A (en) * | 2022-12-06 | 2025-08-01 | Elion Oncology Inc | Combined use of anilouracil and capecitabine for cancer treatment |
| WO2025015267A1 (en) * | 2023-07-13 | 2025-01-16 | Processa Pharmaceuticals, Inc. | Methods of personalizing cancer treatment |
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| GB8629892D0 (en) | 1986-12-15 | 1987-01-28 | Wellcome Found | Antiviral compounds |
| US5157114A (en) | 1988-08-19 | 1992-10-20 | Burroughs Wellcome Co. | 2',3'-dideoxy-3'-fluoro-5-ethyngluridine |
| JP3094036B2 (ja) | 1990-07-19 | 2000-10-03 | ザ ウエルカム ファウンデーション リミテッド | 酵素不活性化剤 |
| IT1255522B (it) * | 1992-09-24 | 1995-11-09 | Ubaldo Conte | Compressa per impiego terapeutico atta a cedere una o piu' sostanze attive con differenti velocita' |
| US5476855A (en) | 1993-11-02 | 1995-12-19 | Mahmoud H. el Kouni | Enzyme inhibitors, their synthesis and methods for use |
| NZ330360A (en) | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US20040028687A1 (en) * | 2002-01-15 | 2004-02-12 | Waelti Ernst Rudolf | Methods and compositions for the targeted delivery of therapeutic substances to specific cells and tissues |
| NZ555176A (en) * | 2004-12-03 | 2010-03-26 | Adherex Technologies Inc | Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817664A (en) * | 1990-09-26 | 1998-10-06 | Glaxo Wellcome Inc. | Uracil reductase inactivators |
Non-Patent Citations (1)
| Title |
|---|
| SPECTORT等: "5-氟尿嘧啶治疗活性的调节剂5-乙炔尿嘧啶", 《国外医学.药学分册》 * |
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| US20060148753A1 (en) | 2006-07-06 |
| AU2005311730B2 (en) | 2011-11-17 |
| JP2012229273A (ja) | 2012-11-22 |
| NZ555176A (en) | 2010-03-26 |
| KR20070098798A (ko) | 2007-10-05 |
| AU2005311730A1 (en) | 2006-06-08 |
| EP1827443A1 (en) | 2007-09-05 |
| US20130184232A1 (en) | 2013-07-18 |
| JP2008521930A (ja) | 2008-06-26 |
| CN101068549A (zh) | 2007-11-07 |
| MX2007006646A (es) | 2007-11-16 |
| WO2006060697A1 (en) | 2006-06-08 |
| WO2006060697A9 (en) | 2006-09-21 |
| US8318756B2 (en) | 2012-11-27 |
| CA2587514A1 (en) | 2006-06-08 |
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