KR20070024479A - Insecticide composition - Google Patents

Abstract

An insecticide composition which contains one or more compounds selected among compounds represented by the formula [I]: and salts of the compounds and further contains a neonicotinoid compound represented by the formula [II]. The insecticide composition has a higher insecticidal effect than compositions separately containing these compounds. Namely, the composition produces a synergistic effect. It is hence possible to reduce the dose of agricultural chemicals or the number of applications. ® KIPO & WIPO 2007

Description

Insecticide Composition {INSECTICIDE COMPOSITION}

The present invention relates to a composition exhibiting excellent insecticidal action, comprising a compound represented by the formula [I] or a salt thereof and a neonicotinoid compound represented by the formula [II], and a method for controlling pests by using a mixture of the compounds. It is about.

Compounds represented by the formula [I] usable in the present invention are compounds known to exhibit insecticidal action (see Patent Documents 1, 2 and 3).

Further, the neonicotinoid compound represented by the formula [II] usable in the present invention is a compound known to have insecticidal action, for example, [Pesticide Manual, 12th edition (Non-Patent Document No. 1)] and the like. The compounds described, such as clothianidine (chemical name: (E) -1- (2-chloro-1,3-thiazol-5-ylmethyl) -3-methyl-2-nitroguanidine; non-patent document number 1, No. 165, page 197; Patent Document No. 4), nitenpyram (chemical name: (E) -N- (6-chloro-3-pyridylmethyl) -N-ethyl-N'-methyl-2-nitro Vinylidenediamine; non-patent document number 1, number 562, page 674; patent document number 5), imidacloprid (chemical name: 1- (6-chloro-3-pyridylmethyl) -N-nimididazolidine- 2-ylideneamine; non-patent document no. 1, no. 446, page 537; patent document no. 6), thiamethoxam (chemical name: 3- (2-chloro-1,3-thiazol-5-yl-methyl ) -5-methyl-1,3,5-oxadiazin-4-ylidene ( Tro) amines; non-patent document no. 1, no. 751, page 896; patent document no. 7), acetamiprid (chemical name: (E) -N-[(6-chloro-3-pyridyl) methyl] -N '-Cyano-N-methylacetamidine; non-patent document number 1, number 6, page 9; patent document number 8), dinotefuran (chemical name: (RS) -1-methyl-2-nitro-3 -(Tetrahydro-3-furylmethyl) guanidine; non-patent document number 1, number 265, page 319; patent document number 9), thiacloprid (chemical name: 3- (6-chloro-3-pyridylmethyl) -1,3-thiazolidine-2-ylidenecyanamide; CAS No. 111988-49-9; Patent Document No. 10) and the like.

As an example of a compound which may be incorporated into the compound represented by the formula [I], a neonicotinoid-based compound as described above together with a number of other pesticides (Patent Documents 1 to 3) is indicated, but the compound is referred to as neonico There is no description about the Example used practically as a mixture with a tinoid type compound.

Patent Document No. 1; Pamphlets of WO 01/070671;

Patent Document No. 2; Pamphlets of WO 03/015519;

Patent Document No. 3; Pamphlets of WO 03/016284;

Patent Document No. 4; Publication of JP-A-Hei 3-157308;

Patent Document No. 5; JP-A-Hei 2-000171;

Patent Document No. 6; JP-A-Sho 61-178981;

Patent Document No. 7; JP-A-Hei 6-183918;

Patent Document No. 8; JP-A-Hei 4-154741;

Patent Document No. 9; JP-A-Hei 7-179448;

Patent Document No. 10; JP-A-Sho 62-207266;

Non-patent document No. 1; Pesticide Manual, 12th Edition, 5 British Crop Protection Council.

Disclosure of the Invention

Problems to be Solved by the Invention

In recent years, environmental pollution due to various chemical components has been identified as a global problem, and the social demand to suppress the release of chemical components into the environment to a minimum level is increasing. It also explores how to control harmful and harmful individuals or pests in the agricultural sector without the use of chemical components, such as the creation or generation of genetically modified crops, the control of pests using their natural enemies, and the physical control of pests. Various studies are being conducted.

However, such methods of controlling pests without the use of chemical components encounter numerous problems, such as their uniquely limited use alone, instability of their effects, etc. in controlling certain diseases or pests, and therefore, pests using chemical components. The demand for control has not been reduced yet.

Means to solve the problem

The present inventors conducted repeated and repeated studies with the specific purpose of reducing the application rate of agricultural chemicals or pesticides from the viewpoint of prevention of environmental pollution and the like, and as a result, the compound represented by the formula [I] and the formula [II] It has been found that mixtures of neonicotinoid-based compounds may have a greater effect than would be expected if the two compounds were used alone, in fact reducing the amount or frequency of application of pesticides or pesticides. It was. In addition, even if the pest is applied to a location other than the site where the pest directly harms, such as the soil of the seed, seed potatoes or seedlings on which the crop is grown or the soil of the main follicles, the mixture may control the pest in an extremely effective manner. It was found that it can. This finding, followed by progressive inquiry, has led to the completion of the present invention.

That is, the present invention relates to the following:

[1] A pesticide composition comprising one or two or more compounds selected from a compound represented by the following formula [I] or a salt thereof and a neonicotinoid compound represented by the following formula [II]:

[Wherein, R ¹ , R ² , R ³ And R ⁴ It is the same or different, each represent a hydrogen atom, C _{1 -6} alkyl group, C _{1 ~ 6} haloalkyl group or a halogen atom; R ⁵ Is a hydrogen atom or a C _{1 -6} al kilgi gt; X is CH or N; n is 0 to 3;

[Wherein Y is CH ₂ , S or NR ⁶ (R ⁶ Is a hydrogen atom or a C _{1 -6} alkyl group) and; Z is N or CH; W is cyano or nitro group; A and B are the same or different, and each is taken represents a hydrogen atom or a C _{1 -6} alkyl group, or together with the adjacent Y, C and N to form a ring represented by the formula:

Wherein ring [A] is a group represented by the formula:

In which R ⁶ Is as defined above; R ⁷ Is a hydrogen atom or a C _{1 -6} alkyl group)}, the formula:

Represents a heterocyclic group selected from pyridyl, thiazolyl and tetrahydrofuryl groups, wherein the heterocyclic ring is optionally substituted by 1 to 3 halogen atoms;

[2] The insecticide composition according to the above-mentioned [1], wherein the compound represented by the formula [I] is a compound represented by the following formula [Ia]:

Wherein the symbols are as defined above;

[3] R ¹ in the compound represented by the formula [Ia] Is a halogen atom or a C _{1 -6} haloalkyl group, R ² Is a halogen atom, R ³ And R ⁵ Each is a C _{1 -6} alkyl group, R ⁴ The insecticide composition according to the above-mentioned [2], wherein is hydrogen or a halogen atom, and X is N;

[4] R ¹ in the compound represented by the formula [Ia] Is a chlorine atom or bromine atom or a trifluoromethyl group, R ² Is a chlorine atom, R ³ Is a methyl group, R ⁵ Is isopropyl group, R ⁴ Is a hydrogen atom or a chlorine atom, X is N, the insecticide composition according to the above-mentioned [2];

[5] The compound represented by formula [Ia] is 2- [1- (3-chloropyridin-2-yl) -3-trifluoromethylpyrazol-5-ylcarbonylamino] -N-isopropyl-3 -Methylbenzamide, 5-chloro-2- [1- (3-chloropyridin-2-yl) -3-trifluoromethylpyrazol-5-ylcarbonylamino] -N-isopropyl-3-methyl Benzamide, 2- [1- (3-chloropyridin-2-yl) -3-chloropyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 5-chloro-2- [1- (3-Chloropyridin-2-yl) -3-chloropyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 2- [3-bromo-1- ( 3-chloropyridin-2-yl) pyrazol-5-yl-carbonylamino] -N-isopropyl-3-methylbenzamide or 2- [3-bromo-1- (3-chloropyridine-2- (1) the pesticide composition according to the above-mentioned [2], which is pyrazole-5-ylcarbonylamino] -5-chloro-N-isopropyl-3-methylbenzamide;

[6] The above-mentioned [1]-, wherein the neonicotinoid compound represented by the formula [II] is clotianidine, nitenpyram, imidacloprid, thiacloprid, thiamethoxam, acetamiprid or dinotefuran. Insecticide composition in any one of [5];

[7] The insecticide composition according to any one of the above [1] to [5], wherein the neonicotinoid compound represented by the formula [II] is clothianidine;

[8] a pest control method comprising applying the pesticide composition according to any one of the above-mentioned [1] to [7] to a position other than a site where the pest directly causes harm;

[9] Two kinds of compounds, i.e., the formula [I] according to any one of the above-mentioned [1] to [7], during the period from the seeding to the seedling-planting of the crops grown by the seedling-planting method. ] A compound or a salt thereof and a neonicotinoid-based compound represented by the formula [II], followed by irrigation to the seedling soil in the form of a mixed solution or scattered on the seedling soil in the form of mixed granules. Pest control method characterized in that;

[10] During the period from the seeding to the seedling-growing of crops grown by the seedling-planting method, two kinds of compounds, namely, as described in any of the above-mentioned [1] to [7] A pest control method comprising growing seedlings using a seedling soil containing a compound represented by the formula [I] or a salt thereof and a neonicotinoid compound represented by the formula [II] in the seedling soil;

[11] Two kinds of compounds, the formulas as described in any one of the above-mentioned [1] to [7], for a period ranging from seedling-planting to growth for crops grown by the seedling-planting method. The compounds represented by [I] or salts thereof and the neonicotinoid compounds represented by the formula [II] are treated with irrigation, planting-hole treatment, planting-hole treated soil incorporation, and main source. A pest control method comprising spraying the soil of the main fabric through plant-root treatment or plant-root treated soil incorporation;

[12] In the case of crops grown by planting or seeding seeds, seed potatoes or bulbs directly on the main fabric, two kinds of compounds, namely, the formula [I] as described in any of the above-mentioned [1] to [7] A pest control method comprising immersing, seeding, or treating a seed, seed potato or bulb with a compound or a salt thereof and a neonicotinoid-based compound represented by the formula [II]. ; And

[13] During the growing period of a crop grown by planting or seeding seeds, seed potatoes or bulbs directly on the main fabric, two kinds of compounds, ie, a formula as described in any of the above-mentioned [1] to [7], A pest control method comprising dispersing a compound represented by I] or a salt thereof and a neonicotinoid-based compound represented by formula [II] in the soil of main fabric through irrigation treatment, main treatment or main mixing of soil. .

Effects of the Invention

The combination of the compound represented by the formula (I) and the neonicotinoid-based compound represented by the formula [II] may express or induce a higher pesticidal effect, ie synergistic effect, than would be expected if each of the compounds were applied alone. This can reduce the amount of application or the number of applications of the pesticide used.

Best mode for carrying out the invention

In some cases, compound [I] or a salt thereof and neonicotinoid-based compound [II] are in the form of geometric isomers and / or structural isomers, and the present invention includes the individual isomers and mixtures thereof.

Regarding the above formulas, represented by R ¹ to R ⁷ A C _{1 -6} alkyl group, for example, a methyl, ethyl, n- propyl, isopropyl, n- butyl, isobutyl, sec- butyl, or tert- butyl is used.

R ¹ To as C _{1 -6} haloalkyl group represented by R ^4, for example, a halogen atom (e.g., F, Cl, Br, I), 1 to 10 (preferably 1 to 5) open-circuit _1-6 substituted C Alkyl groups such as chloromethyl, fluoromethyl, bromomethyl, 2-chloroethyl, dichloromethyl, trichloromethyl, trifluoromethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, heptafluoro Propyl or nanofluorobutyl and the like are used.

R ¹ As the halogen atom represented by R to R ⁴ , a fluorine, chlorine, bromine or iodine atom is used.

As R ^1, a halogen atom and a C _{1 -6} haloalkyl group, and particularly preferred, more preferably a methyl, chlorine and trifluoromethyl.

As R ² , a halogen atom is preferred, and chlorine is particularly preferred. The position of substitution is preferably 2-position when each mother cyclic group is a phenyl group and 3-position when the mother cyclic group is a pyridyl group.

As R ^3, the 3-position and a halogen atom and a C _{1 -6} alkyl group substituted in the position for (the position of substitution is referring the position of the 2-amino benzoic acid is used as the base nucleus), preferably, 3-methyl Particularly preferred.

As R ^4, a hydrogen atom, and 4 or 5-position of the position for substitution at (the position of substitution is referring the position of the 2-amino benzoic acid is used as the base nucleus) a halogen atom and a C _{1 -6} alkyl group Preferred, hydrogen atoms and 5-chlorine.

As R ^5, C _{1 -6} alkyl group and preferably an isopropyl group is particularly preferred.

X represents CH or N, with N particularly preferred.

n is an integer of 0-3 and the integer 1 is especially preferable.

Y represents CH ₂ , S or NR ⁶ , and as R ⁶ , a hydrogen atom or a methyl group is preferable.

As R ^7, C _{1 -6} alkyl group and preferably a methyl group is particularly preferred.

Chemical formula:

As the group represented by, a 6-chloro-3-pyridyl, 2-chloro-5-thiazolyl or 3-tetra hydrofuryl group is preferable.

Y is CH ₂ In the case of, A is preferably a hydrogen atom, while B is preferably a methyl group.

When Y is S, A and B are preferably taken together with adjacent Y, C and N to form a ring.

Y is NR ⁶ When A is preferably a hydrogen atom or a methyl group, while B is preferably a hydrogen atom, a methyl group or an ethyl group, and A and B are preferably taken together with adjacent Y, C and N to form a ring.

As a compound represented by the formula [I], 2- [1- (3-chloropyridin-2-yl) -3-trifluoromethylpyrazol-5-ylcarbonylamino] -N-isopropyl-3-methyl Benzamide, 5-chloro-2- [1- (3-chloropyridin-2-yl) -3-trifluoromethylpyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide , 2- [1- (3-chloropyridin-2-yl) -3-chloropyrazol-5-ylcarbonylamino] -N-isopropyl--3-methylbenzamide, 5-chloro-2- [ 1- (3-chloropyridin-2-yl) -3-chloropyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 5-chloro-2- [1- (3- Chloropyridin-2-yl) -3-chloropyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 2-[(3-bromo-1- (3-chloropyridine- 2-yl) pyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide or 2- [3-bromo-1- (3-chloropyridin-2-yl) pyrazol-5 -Ylcarbonylamino] -5-chloro-N-isopropyl-3-methylbenzamide and the like desirable.

As the neonicotinoid compound represented by the formula [II], clothianidine, nitenpyram, imidacloprid, thiacloprid, thiamethoxam, acetamiprid, dinotefuran, and the like are preferred. Particularly preferred.

The salt of compound [I] may be any salt as long as they are agrochemically acceptable salts. Examples of such salts include inorganic bases (e.g., alkali metals such as sodium, potassium and lithium, etc., alkaline earth metals such as calcium and magnesium, ammonia, etc.), organic bases (e.g., pyridine, collidine, triethylamine, triethanol Amines, etc.), inorganic acids (e.g. hydrochloric acid, hydrobromic acid, hydroiodic acid, phosphoric acid, sulfuric acid, perchloric acid, etc.) or organic acids (e.g. formic acid, acetic acid, tartaric acid, malic acid, citric acid, oxalic acid, succinic acid, benzoic acid, picric acid , Methanesulfonic acid, p-toluenesulfonic acid and the like).

Compound [I] or a salt thereof can be prepared, for example, by the method described in WO01 / 070671, WO03 / 015519 and WO03 / 016284 or a method similar thereto.

Neonicotinoid-based compound [II] is a known compound, and clothianidine, nitenpyram, imidacloprid, thiamethoxam, acetaprid, dinotefuran and thiacloprid are, for example, JP-A- Hei 3-157308 (Patent Document No. 4), JP-A-Hei 2-000171 (Patent Document No. 5), JP-A-Sho 61-178981 (Patent Document No. 6),, JP-A-Hei 6-183918 (Patent Document No. 7), .JP-A-Hei 4-154741 (Patent Document No. 8), JP-A-Hei 7-179448 (Patent Document No. 9) and JP-A-Sho 62-207266 (Patent Document No. 10) or a method similar thereto.

When the composition of the present invention is used as an agrochemical agent such as an insecticide, an insecticide-mite insecticide combination, a fungicide-insecticide combination, and the like, depending on the purpose of use, one or two or more kinds of compounds [I] or salts thereof (preferably One kind) and one or two or more kinds of neonicotinoid-based compounds [II] (preferably one kind) are dissolved or suspended in a suitable liquid carrier, mixed with a suitable solid carrier, or adsorbed thereon. , Forms that can be taken by conventional pesticides, ie wet powders, aqueous suspensions, emulsions or emulsified concentrates, soluble liquids or solutions, ULV preparations, flours, granules, tablets, jumbo preparations, pastes, foamable preparations , Aerosols, microcapsules, coating formulations for seeds, fumigants, smokes, stick preparations for crop irrigation, or oils It is used in the form of formulations such as. If desired, the pesticide preparation may be an ointment base, emulsifier, suspending agent, electrodeposition agent, penetrant, wetting agent, dispersant, stabilizer, binder, flow aid, flocculant, antioxidant, suspending agent, antifoaming agent, anti-freezing agent, preservative, moisture It may be suitably incorporated together with an inhibitor, a UV absorber, a UV scattering agent, a colorant or a suspension stabilizer and the like and may be prepared by a procedure known in the art. That is, the preparation can be prepared by uniformly mixing the compound [I] or a salt thereof and the neonicotinoid compound [II] as well as the various additives described above as well as the liquid or solid carrier.

For example, an emulsifying or emulsifying concentrate can be prepared by mixing the emulsifier and the organic solvent, as well as the compound [I] or a salt thereof and the neonicotinoid compound [II] to be uniformly dissolved. For example, the granules may be prepared by uniformly mixing and dispersing a compound [I] or a salt thereof and a neonicotinoid compound [II] as well as a dispersant (surfactant), a binder and an extender (or a solid carrier). Granulated wet powder and the like can be prepared. For example, a powder (for example, DL powder, etc.) can be produced by mixing compound [I] or a salt thereof, neonicotinoid compound [II], an extender (or a solid carrier), and the like and uniformly pulverizing it. have. For example, compound [I] or a salt thereof and components such as neonicotinoid-based compound [II], a dispersant, etc. are mixed and dispersed using a stirring machine, and then wet milled using Dyno-Mill or the like to fluidize Flowable preparations can be prepared. For example, the compound [I] or a salt thereof, a neonicotinoid compound [II], and a dispersant (surfactant), a binder, a suspending agent and an extender (or a solid carrier) and the like are uniformly mixed, followed by granulation. A jumbo formulation can be manufactured by making it.

Suitable examples of liquid carriers (eg solvents, organic solvents) used are solvents such as water, alcohols (eg methyl alcohol, ethyl alcohol, n-propyl alcohol, isopropyl alcohol, ethylene glycol, etc.), ketones (E.g., acetone, methyl ethyl ketone, etc.), ethers (e.g. dioxane, tetrahydrofuran, ethylene glycol monomethyl ether, diethylene glycol monomethyl ether, propylene glycol monomethyl ether, etc.), aliphatic hydrocarbons ( For example, kerosine, paraffin oil, fuel oil, mechanical oil, etc., aromatic hydrocarbons (eg benzene, toluene, xylene, solvent naphtha, methylnaphthalene, etc.), halogenated hydrocarbons (eg, dichloromethane , Chloroform, carbon tetrachloride, etc., acid amides (e.g., N, N-dimethylformamide, N, N-dimethylacetamide, etc.), esters (e.g., ethyl acetate, butyl acetate, glycerol) Fatty acid esters of rolls), or nitriles (for example, acetonitrile, propionitrile, etc.), and the like, and these include one or two or more (preferably one or more and three or less) in an appropriate ratio. It can be suitably used by mixing.

As solid carriers (ie diluents and extenders), vegetable powders (e.g. soy flour, tobacco powder, flour, wood powder, etc.), mineral powders (e.g. kaolin, bentonite, sepiolith, acid clay, etc.); Water-soluble substances such as silica, talc, diatomaceous earth and powdered mica, such as clay, talc bennetum and powdered talc, silica, lactose, ammonium sulfate, urea, sodium hydrocarbons, sodium thiosulfate, sodium dihydrogen phosphate, sodium acetate and sodium carbonate, etc.), Calcium carbonate, alumina, powdered sulfur or activated carbon, and the like, and these can be suitably used by mixing one or two or more kinds (preferably one or more and three or less) in an appropriate ratio.

As an ointment base, for example, polyethylene glycol, pectin, polyhydric alcohol esters of higher fatty acids such as glycerol monostearate and the like, cellulose derivatives such as methyl cellulose and the like, sodium alginate, bentonite, higher alcohols, polyhydric alcohols such as glycerol One or two or more (preferably one or more, three or less) such as petroleum, white petroleum, liquid paraffin, lard, various vegetable oils, lanolin, dehydrated lanolin, cured oils, resins, etc. are suitable. Or the ointment base is further incorporated with one or two or more (preferably one or more, four or less) of various surfactants described below.

Particularly with regard to surfactants usable as emulsifiers, electrodeposition agents, penetrants, wetting agents or dispersants, the non-ionic surfactants used are, for example, soaps, polyrioxyethylene alkylene ethers (New Calgen D1504, Neugen ET65). , Neugen ET83, Neugen ET157, etc.), polyoxyethylene alkylaryl ethers (Neugen EA92, Neugen EA142, etc.), polyoxyethylene alkylphenyl ethers, polyoxyethylene nonylphenyl ethers (Nonipol 20, Nonipol 100, etc.), polyoxyethylene poly Oxypropylene ether, polyoxyethylene isomerized phenyl ether (Neugen EA87, Neugen EA177, etc.), polyoxyethylene alkyl esters (Ionnet M020, lonnet M0600, etc.), sorbitan fatty acid esters (Reodol SP-S10, Reodol TW-S20 ), Polyoxyethylene sorbitan fatty acid esters, block copolymers of ethylene oxide and propylene oxide (Newpole PE64), alkanol amides of higher fatty acids, al Maleate copolymers (Demol EP), polyhydric alcohol esters (Tween 20, Tween 80, etc.) and the like, and cationic surfactants used include, for example, alkylamine salts, quaternary ammonium salts, and the like; Anionic surfactants that can be used include, for example, metal salts of naphthalene sulfonate condensates, naphthalene sulfonate formalin condensates (NewCalgen FS4, etc.), alkylnaphthalene sulfonates (Sorpol 5115, etc.), metal ligninsulfonates, alkylallyl sulfonates and alkyls. High molecular compounds such as allyl sulfonate sulfate and the like, sodium polystyrenesulfonate, metal salt of polycarboxylic acid, ammonium polyoxyethylene histidylphenyl ether sulfate, higher alcohol sulfonate, higher alcohol ether sulfonate, dialkyl sulfosuccinate (Such as NewCalgen EP7OP) or alkali metal salts of higher fatty acids.

As a stabilizer, an epoxy group, an antioxidant (for example, dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA), tetrakis [3- (3,5-di-tert-butyl-4-hydride) Oxyphenyl) propionyloxymethyl] methane (Irganox 1010), DL-tocopherol, propyl gallate, erythorbic acid, sodium erythorbate, isopropyl citrate, etc.), phosphoric acid, PAP adjuvant (isopropyl acid phosphate), cyclo A compound having dextrin (Toyoderin P), or tall oil fatty acid (Hartall fatty acid) is used, and the above is suited to one or two or more kinds (preferably one or more and three or less). It can mix suitably and can use it suitably.

As the binder, dextrin, alpha-starch, polyvinyl alcohol, gum arabic, sodium alginate, polyvinylpyrrolidone, glucose, sucrose, mannitol or sorbitol and the like are used, which is one or two or more (preferably Preferably, one or more kinds and three or less kinds) can be mixed and used at an appropriate ratio.

As a flow aid, PAP adjuvant (for example, isopropyl acid phosphate), talc, etc. are used, and it is suitable by mixing one type or two types or more (preferably one type or more and three types or less) in an appropriate ratio. Can be used.

As the anticoagulant, white carbon, diatomaceous earth, magnesium stearate, aluminum oxide or titanium dioxide is used, and the above is mixed in one or two or more kinds (preferably one or more and three or less) at an appropriate ratio. Can be suitably used.

As the flocculant, a liquid paraffin, ethylene glycol, diethylene glycol, triethylene glycol or isobutylene polymer (e.g., IP Solvent) and the like are used, which is one or two or more (preferably one or more, 3 or less types) can be mixed suitably and used suitably.

As antioxidant, dibutylhydroxytoluene, 4,4-thiobis-6-tert-butyl-3-methylphenol, butylhydroxyanisole, para-octylphenol, mono (or di- or tri-) (α -Methylbenzyl) phenol, 2,6-di-tert-butyl-4-methylphenol or tetrakis [3- (3,5-di-tert-butyl-4-hydroxyphenyl) propionyl-oxymethyl] methane Etc. can be used suitably by mixing one or two or more (preferably one or more and three or less) in an appropriate ratio.

Floating agents particularly used in the preparation of jumbo preparations preferably include powder bases and the like having, for example, specific gravity of 1 or less (preferably 1 to 0.5). The powder bases are preferably exemplified those having a particle size of 600 μm or less, preferably 600 μm to 10 μm; The inorganic powder base is a naturally-occurring glassy or vitreous material in which one or a plurality of independent air bubbles are supplied through a combustion treatment, for example, with perlite and obsidian. Composed of perlite composed of Shirasu, Shirasu Balloons composed of Shirasu , vermiculite composed of vermiculite, and the like, as well as Phylite, or micro hollow materials based on aluminosilicates produced through combustion treatment, while the organic powder base Higher fatty acids such as stearic acid and palmitic acid, commonly referred to as "wax components", which are in a solid state at ambient temperature, can be exemplified, as well as higher alcohols such as stearyl alcohol, paraffin wax and the like. Because the waxy material is water repellent and resistant to water-penetration, the active ingredient of the pesticide tends to be in the wax ingredient over an extended period of time and is difficult to disperse into water, consequently the active The component is preferably used by mixing with the glass or vitreous hollow material described above.

As the antifoaming agent, a silicone-based antifoaming agent (for example, Antifoam E20, etc.) is used, and the above is suitably used by mixing one or two or more kinds (preferably one or more and three or less) in an appropriate ratio. Can be.

As the cryoprotectant, ethylene glycol, diethylene glycol, polyethylene glycol, or glycerol may be used, and the above may be suitably used by mixing one or two or more kinds (preferably one or more and three or less) in an appropriate ratio. have.

As a preservative, butyl paraben, potassium sorbate, etc. can be used, and it can use suitably the 1 type, or 2 or more types (preferably 1 or more types, 3 or less types) by mixing in an appropriate ratio.

As a moisture inhibitor, anhydrous gypsum, a silica gel powder, etc. are used, The above can mix suitably one type or two types (preferably 1 type or more, 3 types or less) in an appropriate ratio, and can use it suitably.

As a UV absorber, 2- (2'-hydroxy-5'-methylphenyl) benzotriazole, 2-ethoxy-2'-methyloxalic acid bisanilide or dimethyl succinate / 1- (2-hydroxyethyl) -4 -Hydroxy-2,2,6,6-tetramethylpiperidine polycondensate, etc., and the above-mentioned one or two or more kinds (preferably one or more and three or less) It can be used suitably.

Titanium dioxide or the like is used as the UV scattering agent, and one or two or more (preferably one or more and three or less) may be mixed and used at an appropriate ratio.

As a coloring agent, Cyaningreen G, Eriogreen B400, etc. are used, The above can mix suitably one type or two types (preferably 1 type or more, 3 types or less) in an appropriate ratio, and can use it suitably.

As the suspension stabilizer, polyvinyl alcohol (such as Gohsenol GH17), clay minerals (such as Kunipia F, VEEGUM R, etc.), or silicon dioxide (Aerosil C0K84, etc.), etc., are used. Preferably, one or more types and three or less types) can be mixed and used in an appropriate ratio suitably.

Jumbo formulations, powders, granules, granulated wet powders, wet powders and the like can be used after being separately packed in 20 to 200 g units in a bag made of a water-soluble film to simplify its dispersion. The water-soluble film may be polyvinyl alcohol, carboxymethylcellulose, starch, gelatin, polyvinylpyrrolidone, polyacrylic acid and salts thereof, Pullulan (trade name: starch-based polysaccharide) or Paogen (trade name: water-soluble thermoplastic polymer). Is illustrated.

In the preparation of the compositional preparations according to the invention, if so, it is possible to control the release of either or both of the active ingredients, thereby extending the pesticidal effect (s) of the preparations or of the preparations over an extended period of time. You can keep it.

The combined compound [I] or salts thereof and neonicotinoid-based compound [II] are usually contained in the composition of the present invention in an amount of about 0.1 to 80% by weight based on the total amount of the composition. When they are used in the form of, for example, emulsified concentrates, soluble liquids, wet powders (eg, granular wet powders), aqueous suspension formulations or microemulsions, they are usually suitably about 1 to 80. It is incorporated into the formulation in an amount ranging from about 10% to 50% by weight. When they are used in the form of preparations such as oil solutions, powders and the like, they are suitably formulated into the preparations in amounts ranging from about 0.1 to 50% by weight, preferably from about 0.1 to 20% by weight. When they are used in the form of formulations such as granules, tablets, jumbo preparations and the like, they are usually incorporated into the preparations in amounts ranging from about 0.5 to 50% by weight, preferably from about 0.5 to 10% by weight.

Compound [I] or a salt thereof and neonicotinoid-based compound [II] are preferably in the ratio of the weight ratio of 1: 0.1 to 1:20, more preferably in the ratio of the weight ratio of 1: 0.2 to 1:10. It is contained in the composition.

The content of additives other than the above-mentioned active ingredients is usually about 0.001 to 99.9% by weight, preferably about 1 to 99% by weight, although they vary depending on the type or content of the active ingredient of the pesticide, the formulation of the pesticide preparation, and the like. Range. More particularly, based on the total amount of the composition, the surfactant is usually in an amount in the range of about 1 to 30% by weight, preferably in the range of about 1 to 15% by weight, in an amount in the range of about 1 to 20% by weight, and Preference is given to adding the carriers in amounts ranging from about 1 to 90% by weight, preferably from about 1 to 70% by weight. Specifically, in the preparation of liquid formulations, water is usually added in amounts ranging from about 20 to 90% by weight of the surfactant, usually in amounts ranging from about 1 to 20% by weight, preferably from 1 to 10% by weight. It is desirable to. When emulsifying concentrates are produced, it is usually preferred to add surfactants and organic solvents in amounts ranging from about 1 to 30% by weight, preferably from about 2 to 15% by weight. For the preparation of granular wet powders, not only extenders such as lactose, ammonium sulfate or clays, etc., but also surfactants in amounts ranging from about 0.1 to 10% by weight, preferably from about 0.5 to 5% by weight, and from about 0.1 to 15 Preference is given to each addition of the binder in an amount in the range of% by weight, preferably about 0.5 to about 5% by weight. For the preparation of granules, not only extenders such as clays, but also surfactants in amounts ranging from about 0.1 to 10% by weight, preferably about 0.5 to 5% by weight, and about 0.1 to 10% by weight, preferably about 0.5 It is preferred to add each stabilizer in an amount in the range of from 5% by weight. For the preparation of jumbo preparations, not only extenders such as clays, but also surfactants, in amounts ranging from about 0.1 to 15% by weight, preferably from about 0.5 to 5% by weight, preferably from about 0.5 to 10% by weight, preferably about Preferably, the binder is added in an amount in the range of 0.5 to 5% by weight, and the suspending agent in an amount in the range of about 0.5 to 40% by weight, preferably about 1 to 20% by weight.

When wet powders (eg granular wet powders) and the like are used, they are preferably sprayed or sprayed after dilution (eg, about 100--5,00-fold dilution) suitably with water and the like.

Moreover, the compositions of the present invention suitably include other insecticide active ingredients, mite repellent active ingredients, fungicide active ingredients, nematicide active ingredients, herbicide active ingredients, plant hormones, plant growth regulators, synergists (e.g. pipepe Ronyl butoxide, sesamex sulfoxide, MGK 264, N-decylimidazole, WARF-resistant, TBPT, TPP, IBP, PSCP, CH ₃ I, t-phenylbutenone, diethyl maleate, DMC, FDMC, ETP, ETN), attractants, insect repellents or chemical fertilizers, etc., may be used after incorporation with active ingredients of pesticides other than compound [I] or salts thereof and neonicotinoid compounds [II].

Examples of pesticidal active ingredients, mite killing active ingredients and bactericidal active ingredients that can be incorporated into the compositions of the present invention are described below:

Pesticide Active Ingredients:

O-ethyl O-4-nitrophenyl phosphonothioate (EPN), acetate, isoxation, isopenfos, isoprocarb, erythrimphos, oxydepropos, quinalfoss, cardusafos, chlor Ethoxy Force, Chlorpyriphos, Chlorpyriphos-methyl, Chlorophenbinfoss, Salityone, Cyanophos, Disulfotone, Dimethoxate, Sulprophos, Diazinon, Thiomethone, Tetrachlorbinfos, Tebupyrim Force, trichlorphone, naled, bamidothione, pyraclophos, pyridapention, pyrimifos-methyl, phenythrothione, pention, pentoate, butathiophos, prothiophos, propaphos, Propenophos, Benclothiaz, Posalon, Phosthiazate, Marathione, Metidathione, Mettolcarb, Monochromophos, Phenobcarb (BPMC), 3,5-silyl N-methylcarba Mate (XMC), Alaniccarb, Ethiophencarb, Carbaryl, Carbosulfan, Carbofuran, Thread Carb, Cloetocarb, Thiodicarb, Triamate, Pyrimicarb, Phenoxycarb, Phenothiocarb, Furateocarb, Propoxur, Bendiocarb, Benfuracarb, Metomil, acrinatrin, imiprotrin, etofenprox, cycloprotrin, sigma-cypermethrin, sihalothrin, cyfluthrin, cypermethrin, silafluorophene, tefluthrin, deltamethrin, Tralomethrin, penvalerate, phenpropatrine, flucitrinate, fluvalinate, flufenprox, fluproxyfen, propfluthrin, beta-cifluthrin, benfluthrin, permethrin, cartop , Thiocylam, bensultope, avermectin, emamectin-benzoate, chlorfluazuron, cyromazine, diafenthiuron, dichlorbose, diflubenzuron, spinosine, spiromesifen, tflubenzuron, Tebufenozide, hydroprene, vaniliprole, pimetrozine, blood Proxifene, fipronil, flufenoxuron, buprofezin, hexaflumuron, milbomycin, lufenuron, chlorfenapyr, pyridalyl, flufendiamide, SI-0009, metofluthrin, nobiflumuron, Dimeflutrin, cyflumetofen, pyraflulol and pyriprolol.

Mite insect repellent active ingredients:

Clofentezin, dienochlor, tebufenpyrad, pyridabene, hexiax, phenazaquine, phenpyroximate, ethoxazole, amitraz, bromopropylate, fenbutatin oxide, pyrimidipene, BPPS (Propargite), tebufenpyrad and dicopol.

Bactericidal Active Ingredients:

Iprobenfos (IBP), Ampropyl Force, Edifene Force, Chlorthiophos, Toclofos-methyl, Pocetyl, Icconazole, Imazalyl, Imibenconazole, Etaconazole, Epoxyconazole, Ciprocose Nazol, Dinicoconazole, Diphenoconazole, Tetraconazole, Tebuconazole, Triadimenol, Triadimefon, Triticonazole, Triporin, Viteranol, Vinicosol, Phenarimol, Phenbuconazole, Fluorine Trimazole, furconazole-cis, flusilazole, flutriafol, bromuconazole, propiconazole, hexaconazole, pefurazoate, fenconazole, myclobutanyl, metconazole, carbenzazine, Devacarb, prothiocarb, benomil, maneb, TPN, isoprothiolane, iprodione, iminottadine-albesil, iminottadine-triacetate, etirimole, ethriazole, oxadixyl, oxycarboxycin , Oxolinic acid, opurase, kasugamycin, carboxycin, captan, clozilacon, chlor Ventiazone, Cyprodinyl, Ciprofuram, Dietofencarb, Diclofluanide, Diclomezin, Geneb, Dimethymolol, Dimethomorph, Dimefluazole, Thiabendazole, Thiopa Nate-Methyl, Tifluzamide, Teclophthalam, Triazide, Triclamid, Tricyclazole, Tridemorph, Triflumizol, Validamycin A, Hymexazole, Piracarbolide, Pyrazophos , Pyridenox, pyrimethanyl, pyroquilon, perimzone, fenpiclonil, phenpropidine, phenpropimolp, phthalide, furametpyr, furlaxyl, fluazinam, purcarbanyl, fluquinacona Sol, fludioxonil, flusulfamid, flutolanyl, butiobate, prochloraz, procmidone, probenazole, benalactyl, benodanil, pensicuron, myclozoline, metallaxyl, metsulfobox , Metfuroxam, mepanipyrim, mepronyl, cresoxime-methyl, azoxystrobin, metominost Robin (SSF-126), carpropamide, acibenzoa-S-methyl, orissastrobin, pyraclostrobin, ventiavaricarb, boscalid, methrafenone, fluoxastrobin, proquinazide , Flumorph, prothiooxazole, penthiopyrad, fluoropicolide, pistil, SYP-Z071 and MTF-753.

All of the above-mentioned "other active ingredients of pesticides" are known active ingredients of pesticides. The other active ingredient of the pesticide may be contained in the composition in one kind or two kinds or more (preferably one kind or more and three kinds or less).

The compositions of the present invention show improved stability in mammals and crops, while they have improved pesticidal action against numerous species of pests (including arthropods but not class Insecta ).

When two or more kinds of pesticide compounds are mixed for the purpose of enhancing the efficacy or broadening the range of target pests to be controlled, studies on new applications are generally carried out by simply adding an application amount determined for a single application of the pesticide compound, This increases the risk of causing chemical damage. In the combination treatment according to the invention, unlike treatment through a single application of compound [II], compound [I] itself is largely free of risk of causing chemical damage, and consequently the chemical damage caused by the treatment. The risk of causing is substantially negligible. Since the composition may produce synergistic effects, in addition, the application amount of either or both of compounds [I] and [II] may be reduced at the application amounts specified for a single application of the compound, thereby reducing chemical damage The risks that result can be greatly reduced.

The composition of the present invention is specifically applicable to the control of pests described below, for example:

In other words, the composition of the present invention is effective in control of particular pests, examples of such pests are: pests of the species hemi aerodactyl (Hemiptera), For example, glass derma Lugo Island (Eurydema rugosum), Scotty Bruno Farah Metalurgs is (Scotinophara lurida), granules Thor Tooth Carol tooth bar (Riptortus clavatus), Stephanie Tees Nasi ( Stephanitis nashi ), Lao del Pax Austria Tel Ruth (Laodelphax striatellus), Neela Parque Bata Lou Regensburg (Nilaparvata lugens), four ticks Forte Shin-stitcher sepseu (Nephotettix cincticeps), Unas piece Yano City's linen (Unaspis yanonensis ), Apis Glycines ( Aphis glycines ), lipapis Erie Simi (Lipaphis erysimi), Breda Vico Rhine To Brassica (Brevicoryne brassicae), Apichatpong's notice feeder (Aphis gossypii), North America's Peer to Chicago (Myzus persicae ), Aulaccortum Solani (Aulacorthum solani ), apis Coke to Spira (Aphis spiraecola), bemi Asia Another sacrifice (Bemisia tabaci), tree right Death Valley Bar Fora Rio Room (Trialeurodes vaporariorum), cattle telra City Jabalpur Blow (Sogatella furcifera ), Empoasca O nukiyi (Empoasca onukii), Pseudomonas nose kusu Combs Torquay (Pseudococus comstocki), Plastic sheet Noko kusu Li (Planococcus citri ), Iseria Darfur periods (Icerya Purchasi), Plow Tia Crystal rieyi sarcoidosis lease Parque booth (Plautia staliEysarcoris parvus ), etc. ; Les kinds of pests pidop Terra (Lepidoptera), For example Spofdorf Litura ( Spodoptera) to litura), flu telra xylene Stella (Plutella xylostella ), pierres Raphae Crewe City Bora (Pieris rapae crucivora ), chilo suleilessis ( Chilo supppressalis), Outlet Grappa Nigrisigna ( Autographa nigrisigna), Halley Kobe fail-fast Asulta ( Helicoverpa assulta), the shoe dalre thiazol Sepharose latte (Pseudaletia separate ), Mammstra To Brassica (Mamestra brassicae), toxins, blood Ah yes Come and Paz City Ata (Adoxophyes orana fasciata), rowing tar tea As having gate (Notarcha derogate), keuna Palo Croix Systems Medi-day lease (Cnaphalocrocis medinalis), Lima Oh neoplasm? Ofer cool Pasteurella (Phthorimaea operculella), fills Cri Versus Poly (Chilo polychrysus), typography manager Las royalty reutul (Typoryza incertulas), Spodoptera Exigua ( Spodoptera) exigua), Agrobacterium teeth firmly Tomb (Agrotis segetum), Agrobacterium-Tees Epsilon ( Agrotis ipsilon ), heliotis Oh reumi Gera (Heliothis armigera ), Heliotis Non-resense ( Heliothis virescens), Rio Tees Hell ZE (Heliothis zea), naranga ah four sense (Naranga aenescens ), Austria Nubilis ( Ostrinia nubilalis ), Austria Furnakalis ( Ostrinia furnacalis), Parque Country Beat the other (Parnara guttata ), Adoxopyes sp . (Adoxophyes sp.), Carlophtilia See table (Caloptilia theivora ), philonomic Posey Lin gone Ella (Phyllonorycter ringoneella), carboxylic or Nipponesis ( Carposina niponensis), poly gras Molecular other stars (Grapholita molesta), between the dia Pomonella ( Cydia pomonella ) and the like; Kolreoh kinds of pests aerodactyl (Coleoptera), for example, greater than or draw epilra Tea fertile punkeu Tata ( Epilachna vigintioctopunc tata), aulla Inc., Raleigh, Rafael's mother (Aulacophorafemoralis), Philo Tre other Get up registry (Phyllotreta striolata ), Oulema oryzae ), Exkinok Nemus American Surgical mouse (Echinocnemus squameus), lithography Loft Ruth Orizophilus ( Lissorhoptrus oryzophilus), St Anthony's labor Gran display (Anthonomus grandis ), Calosaurus Kinen sheath (Callosobruchus chinensis), Spanish catapult Ruth Vena tooth (Sphenophorus venatus), Four pilriah Field artillery NIKA (Popillia japonica), do cyano Cuprea ( Anomala cuprea), dia bromo urticae spp . (Diabrotica spp.), Rep Martino Tar Co. Dechemineta ( Leptinotarsa decemlineata), oh that Rio Tess spp. ( Agriotes spp .), Lacioderma Three Rene Rico (Lasioderma serricorne), no trail Taunus Verbier Ski Bar (Anthrenus verbasci), Solarium tree view Castaneum ( Tribolium castaneum), Rick Tooth Brewer Neuss (Lyctus brunneus), Arnaud flow Fora Do Sciacca (Anoplophora malasiaca), Tommy kusu Fini is Fernand (Tomicus piniperda ) and the like; Insect pests of the species deep TB (Diptera), for example museuka FIG scalpel urticae (Musca domestica), Culex Poppies Palence ( Culex popiens pallens), Taba Taunus Trigonus ( Tabanus) trigonus ), Delia Antique ( Delia antique ), Delia Plastic Natura (Delia platura), anopheles Synensis ( Anopheles sinensis), Agrobacterium mija duck material (Agromyza oryzae), hydroxypropyl Lely ah Draw up three (Hydrellia griseola), the rope's claw duck material (Chlorops oryzae ), dacus Cucurbita ( Dacus cucurbitae), Serra's identity Copying the Tata (Ceratitis capitata ), Liriomiza Tripolii ( Liriomyza trifolii ) etc .; Species of insects to climb Saratov TB (Orthoptera), for example a star Roku US Gras Astoria (Locusta migratoria), African or grilled talpa (Gryllotalpa Africana ), Oxy Preconditioning N-Sys (Oxya yezoensis), oxy-ah Jaffa NIKA (Oxya japonica ) and the like; Species of pest S.P.A. Smirnoff TB (Thysanoptera), e.g. TRIPS Tabaki ( Thrips tabaci), TRIPS Parque US (Thrips parmi), you Ella Frances Cleveland Okki Dental lease (Frankliniella occidentalis), Bali Upper Lips non Miss Forde (Baliothrips biformis), Le Ski Tote Lips D'buy leases (Scirtothrips dorsalis), etc .; Species of pest Hime Smirnoff TB (Hymenoptera), for example O Italia rojae (Athalia rosae), Acropolis Mir-Mex spp . ( Acromyrmex spp .), solenoid spp . ( Solenopsis spp .) and the like; Pests of soil and Blau Oradea (Blattodea), e.g. Blatella Germanica ( Blattella germanica ), Peripheretta Loosened labor (Periplaneta fuliginosa), Ferry Plastic Neta artillery NIKA (Periplaneta japonica), etc. Plastic Perry Neta americana (Periplaneta Americana); Nematodes, such as Apelencoides Chopping assay (Aphelenchoides besseyi), Noto ethylene kusu Arcless ( Nothotylenchus acris ) and the like; Thermites, such as Coptermermes Formosa Augustine (Coptotermes formosanus), Spanish Leti Cooley Thermes La Tooth (Reticulitermes speratus), five donto Termez Formosa Augustine (Odontotermes formosanus ), Cryptotermes Domestikus ( Cryptotermes domesticus) and the like.

In addition, the compositions of the present invention may be prepared by eradication of arthropods and parasites that live in and / or on the bodies of river vertebrates, such as humans, cattle, sheep, goats, pigs, poultry, dogs, cats, and fish. In addition to maintaining public health, it can be used for the treatment of livestock diseases and for livestock farming. remind An example of a parasite is Aedes spp . ( Aedes spp .), Anopheles spp . ( Anopheles spp .), coolex spp . ( Culex spp .), culicodes spp . ( Culicodes spp.), Musca spp . ( Musca spp .), hypoderma spp . (Hypoderma spp.), Gas Tero Phil Ruth spp . ( Gasterophilus spp .), Hamatovia spp . (Haematobia spp.), Taba Taunus spp . ( Tabanus spp .), Sirium spp . ( Simulium spp .), triatoma spp . (Triatoma spp.), Petit drawer TB (Phthiraptera) (e.g., Tamar Linea spp (Damalinia spp.), he or tooth Reno spp . ( Linognathus spp .), haematophytopus spp . (Haematopinus spp .)), Fleas (for example, Ktenosepalides spp . ( Ctenocephalides spp .), xenosila spp . ( Xenosylla spp .), etc.) or monomorium Pharaonis (monomorium pharaonis ) and the like.

The compositions of the present invention exhibit extremely low toxicity and can be used as good pesticide compositions.

For example, the compositions of the present invention can be sprayed over paddy fields, fields, orchards, non-cultivated wastelands, homes, etc. using known methods so that the pests can contact or ingest the compositions of the present invention. To eradicate the live pests (harmful insects) described above. In another embodiment of the present invention, for example, the compositions of the present invention are administered to vertebrates internally (in the body) or externally (on the body surface), thereby preventing pests on said vertebrates or parasites. Can eradicate it.

With regard to a particular method of dispersing a combination formulation comprising a composition of the present invention, the same method as that of a general pesticide dispersing method can be used. In addition, formulations each containing a single different active ingredient can be mixed and dispersed in use. The method of spreading the pesticide preparation may include foliage application, trunk or bark application, ULV dispersion, granule foliar-application, soil (land or soil application), soil drenching. , Water-surface application, soil incorporation, nursery bed incorporation, seeding-raising box treatment, nurse bed treatment, plant foot treatment , Planting furrow treatment, planting row treatment, side row treatment, trunk or bark drenching, trunk or bark spreading, seed coating or seed It may be exemplified by dressing, seed immersion or seed soaking, poison bait, water mixing or mixing for fertilizer incorporation or irrigation, but not limited thereto. . When dispersing a combination preparation comprising the composition of the present invention or a mixture of preparations each containing a single different active ingredient, at any time before planting in the case of treatment of seeds, seed potatoes or bulbs; For the treatment of soil, although it may be any time during the growing period after live planting, it may be when sowing, seedling or live planting for improved efficacy; Foliage spreading or dispensing may be any time during the seedling and growth periods on the farm.

In the case of seeding on a seedling soil in which a combination formulation comprising the composition of the invention or a mixture of formulations each comprising a single different active ingredient is incorporated, provisional planting may be performed using the seedling soil. When, or if the soil is treated through solution irrigation or granule dispersion during the growing period, all pests that appear during the growing period can also be eradicated.

In the case of seedlings, as a scattering method, treatment may be carried out by incorporation of soil on the entire surface of the field or furrow before planting, and may also be treated by spraying granules or irrigation of the solution into planting holes. Moreover, after planting, the granules can be treated immediately by dispersing the granules in plant roots or by irrigation of the solution.

Crops grown on farms may be treated with soil as well as seed treatment on the entire surface or furrows of the field before planting.

Compositions of the present invention may be used in combination with natural enemy preparations, in combination with natural enemies (e.g., natural pests such as parasite bees and carnivorous beetles, carnivorous mites, parasitic nematodes, pest-pathogenic microorganisms, etc.) Integrated Pest Management (IMP) can be promoted through the use of a combination of, combinations with genetically modified crops, combinations with attractants and insect repellents.

For example, in cabbage cultivation, in the control of cabbage moths using pheromones to disrupt signal transduction or by the use of natural enemies, such control methods are less effective or completely ineffective if the population density of the pests to be controlled is high. Known. Compound [I] or a salt thereof, or a neonicotinoid compound [II] in farmland in which the population density of Chinese cabbage moth is suppressed to an extremely low level through the soil treatment of the composition of the present invention carried out at the time of planting cabbage. ], When it begins to lose its residual effect, can interfere with signal transmission or use natural enemies thereby greatly guaranteeing the originally intended effect of such signal interference or natural use, and thus over extended periods of time I am sure that control can continue to work. Moreover, in pest control by interruption of signal transmission using pheromones or by the use of natural enemies, there arises a problem of propagating pests that are not targets to be controlled. Under these circumstances, the composition of the present invention can be applied to suppress the proliferation of pests other than targets, which is a problem that has become a major concern in controlling pests by obstruction of signal transmission or use of natural enemies, thus improving It can provide much more integrated pest control.

The application amount of the composition of the present invention may vary widely, for example, depending on the application time, location and method, but preferably the active ingredient per hectare (compound [I] or a salt thereof and a neonicotinoid-based compound [II] Total amount of is applied) in an amount of about 0.3 to 3,000 g, preferably about 50 to 1,000 g. When the composition of the present invention is formulated in the form of a wet powder, about 0.1 to 1,000 ppm of the active ingredient (total amount of the compound [I] or a salt thereof and a neonicotinoid-based compound [II]) at the time of foliage spread, preferably It is preferred to be dispersed after dilution to a final concentration of about 10 to 200 ppm, and to a final concentration of about 1 to 10,000 ppm, preferably about 100 to 2,000 ppm when irrigation into the soil.

Hereinafter, the present invention is illustrated in more detail with reference to the following examples and test examples.

In the examples described below, compounds (I-1), (I-2), (I-3), (I-4), (I-5) and (I-6) are each 2- [1- (3-chloropyridin-2-yl) -3-trifluoromethylpyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 5-chloro-2- [1- (3 -Chloropyridin-2-yl) -3-trifluoromethylpyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 2- [1- (3-chloropyridine-2- Yl) -3-chloropyrazole-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 5-chloro-2- [1- (3-chloropyridin-2-yl) -3- Chloropyrazole-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 2- [3-bromo-1- (3-chloropyridin-2-yl) pyrazole-5-ylcar Bonylamino] -N-isopropyl-3-methylbenzamide and 2- [3-bromo-1- (3-chloropyridin-2-yl) -pyrazol5-ylcarbonylamino] -5-chloro- It is understood to refer to N-isopropyl-3-methylbenzamide.

Example 1

5 parts of compound (I-1), 8 parts of clotianidine, nonionic surfactant (trade name: Noigen EA-177; manufactured by Dai-ichi Kogyo Seiyaku CO., Ltd.) 0.5 part, anionic surfactant (brand name: 2 parts of New Calgen FS-4; manufactured by Takemoto Oils & Fats Co., Ltd.), 2 parts of polyvinyl alcohol (trade name: Gohsenol GH-17; manufactured by Nippon Synthetic Chemical Co., Ltd.), 0.1 part of butylparaben and water 82.4 parts are mixed and sufficiently dispersed using a high speed agitation machine, followed by wet grinding using a grinder "Dyno-Mill" (manufactured by Sinmaru Enterprise Co., 1.0 mm glass beads, 80% filling, 15 m / sec ambient speed). (1 pass) to obtain a fluidizing formulation.

Example 2

5 parts of compound (I-2), 8 parts of cloantiidine, 0.5 parts of nonionic surfactant Noigen EA-177, 1.5 parts of anionic surfactant New Calgen FS-4, silicon dioxide (trade name: Aerosil C0K84; Nippon Aerosil Co 2 parts, polyvinyl alcohol (trade name: Gohsenol GH-17) 2 parts, ethylene glycol 7 parts, silicone-based antifoaming agent (brand name: Antifoam E-20; manufactured by Kao Corp.) 0.2 parts, butylparaben 0.1 parts and 73.7 parts of water were mixed and sufficiently dispersed using a high speed stirring machine, followed by a grinder "Dyno-Mill" (manufactured by Sinmaru Enterprise Co., 1.0 mm glass beads, 80% filling rate, ambient speed 15 m / sec) Wet grinding (one pass) using to obtain a fluidized formulation.

Example 3

1 part of compound (I-1), 1 part of clotianidine, 0.5 parts of nonionic surfactant (trade name: New Pole PE-64; manufactured by Sanyo Chemical Industries Ltd.), 4 parts of alpha-starch and 93.5 parts of clay are uniformly The mixture was mixed with 5-10 parts of water, kneaded and then granulated by extruding through a 0.8 mmφ-screen. The resulting granular material was dried at 60 ° C. for 1 hour to give a granule formulation.

Example 4

A solution of 20 parts of nitenpyram and 80 parts of cyclodextrin (trade name: Toyoderin P; manufactured by JT Foods Co., Ltd.) in 400 parts of water was spray-dried to obtain cyclodextrin clathrate A of nitenpyram.

1 part of compound (I-2), 5 parts of cyclodextrin clathrate A, 2 parts of anionic surfactant (trade name: New Calgen EP-70P; manufactured by Takemoto Oils & Fats Co., Ltd.), 10 parts of dextrin NDS, and 82 parts of clay were uniformly mixed and the mixture was mixed with 5 to 10 parts of water and the same procedure as described in Example 2 was carried out to obtain a granule formulation.

Example 5

0.2 parts of compound (I-1), 0.15 parts of clotianidine, 2 parts of anionic surfactant New Calgen EP-70P, 0.2 parts of flocculant IP Solvent, 1 part of white carbon and 96.45 parts of clay, followed by fine grinding Thus, DL powder formulation was obtained.

Example 6

0.2 parts of compound (I-1), 1.25 parts of cyclodextrin clathrate A prepared in Example 4, 2 parts of anionic surfactant New Calgen EP-70P, 0.2 parts of flocculant IP Solvent, 1.5 parts of white carbon and 94.85 parts of clay It was kneaded uniformly and then finely ground to obtain a DL powder formulation.

Example 7

0.2 parts of compound (I-2), 0.15 parts of imidacloprid, 1 part of tall oil fatty acid (trade name: Hartall FA-1; manufactured by Harima Chemicals, Inc.), 0.2 parts of flocculant IP Solvent, 1.5 parts of white carbon, and 95.1 parts of clay Dough was then finely ground to obtain a DL powder formulation.

Example 8

5 parts of compound (I-4), 8 parts of clothianidine, 7 parts of anionic surfactant (trade name: NewCalgen 98147TX; manufactured by Takemoto Oils & Fats Co., Ltd.) and N- (n-dodecyl) pyrroli 80 parts of money (trade name: AGSOLEX12; manufactured by ISP TECHNOLOGIES INC.) Were uniformly mixed and dissolved to obtain an emulsified concentrate.

Test Example 1: Spodoptera by Immersion Treatment of Bait Cultivated Plant Insecticidal effect on the re-Natura (Spodoptera litura)

The test compound was dissolved by addition of acetone containing 5% of Tween 20 (trade name) at a rate of 0.1 ml per 1 mg of test compound, and the solution was diluted to a predetermined concentration with a 5,000-fold diluted DAIN aqueous solution, followed by primary After the leaves were fully developed, the soybean leaves were treated by immersion in the insecticide solution for several seconds. After drying the pesticidal solution, was cut out of four primary leaves and put in the ice cream cup (with the space of 180 ml), it is in Spodoptera Litura ( Spodoptera) 10 larvae of litura ) were released. The ice cream cups were kept in a culture room kept at a constant temperature (25 ° C.) and the number of dead larvae was counted after 3 days. The mortality rate of the larvae was calculated by the following equation, and the results are shown in Table 1.

Equation 1

Larval mortality = (number of dead larvae) / (number of test larvae) x 100

Spodoptera by dipping of leaves Insecticidal effect on soybean leaves for Lee Ventura compound Compound concentration (ppm) Mortality rate after 3 days,% Compound (I-2) 0.03 30 Clotianidine 0.03 0 Compound (I-2) + Clotianidine 0.03 + 0.03 70 * 30 ** fist : * ; Activity (real effect) found by the combination of two kinds of compounds **; Activity calculated by the Colby equation (expected effect)

The effect obtained by the combination of two active compounds exceeds the expected value E as calculated by the below-described equation of Colby et al. And it appears that a synergistic effect exists.

[Equation 2]

E = X + Y-X

(In the meal,

E = mortality of larvae obtained when active compounds A and B are used at concentrations of m and n, respectively;

X = mortality of the larva when active compound A is used at a concentration of m;

Y = mortality of the larva when active compound B is used at a concentration of n).

As shown in Table 1, it was found that Compound (1-2), when used as a mixture with clotianidine, results in a greater pesticidal effect than would be expected when used alone.

Test Example 2: Spodoptera by Immersion of Roots of Bait Cultivated Plants Insecticidal effect on Lee Ventura

The pesticide solution prepared by dissolving the test compound by adding acetone containing 5% of Tween 20 (trade name) at a rate of 0.1 ml per 1 mg of the test compound and diluting the solution to a predetermined concentration with ion-exchanged water was used. Block Erlenmeyer flasks (100 ml) were filled and the roots of soybean plants in the development stage of the primary leaves were washed with running water to remove the soil and then immersed. After 5 days of root soaking, the two primary leaves were cut out and placed in an ice cream cup (with 180 ml of space), in which 10 three larvae were released. The ice cream cups were kept in a culture room controlled at constant temperature (25 ° C.) and counted the number of dead larvae after 5 days. The mortality rate of the larvae was calculated by the following equation, and the results are shown in Tables 2 and 3.

[Equation 3]

Larval mortality = (number of dead larvae) / (number of test larvae) x 100

Spodoptera by dipping of roots Insecticidal effect on soybean leaves for Lee Ventura compound Compound concentration (ppm) Mortality rate after 5 days,% Compound (I-1) 0.007 55 Thiamethoxam 0.007 0 Compound (I-1) + thiamethoxam 0.007 + 0.007 80 * 55 ** fist : * ; Activity (real effect) found by the combination of two kinds of compounds **; Activity calculated by the Colby equation (expected effect)

compound Compound concentration (ppm) Mortality rate after 5 days,% Compound (I-6) 0.00032 0 Clotianidine 0.00032 0 Compound (I-6) + Clotianidine 0.00032 + 0.00032 65 * 0**

As shown in Table 2, Compound (I-1), when used as a mixture with thiamethoxam, has been found to cause greater pesticidal effects than would be expected when used alone, due to mixing Synergistic effects were observed.

As shown in Table 3, it has been found that Compound (I-6), when used as a mixture with clotianidine, results in a larger pesticidal effect than would be expected when used alone, and mixed Synergistic effects were observed.

Test Example 3: Insecticidal effect on the fill and suppeu ressal less (Chilo suppressalis) through a soil drench treatment with the pesticide solution

The test compound was dissolved by adding acetone containing 5% of Tween 20 (trade name) at a rate of 0.1 ml per 1 mg of the test compound, and the solution of the pesticide prepared by diluting the solution to a predetermined concentration with ion-exchanged water was used per plant. It was irrigated onto the surface of the growing soil (5 to 6 live plants / plants in paper pot) in the 2.5- to 3-leaf stage at a rate of 1 ml. After 2 days, stems about 2 cm high on the soil surface were cut out and placed in a test tube, in which 10 Chiloblesiless 3-larvae were released. The test tubes were placed in a culture chamber controlled to constant temperature (25 ° C.) and the number of live larvae was counted after 4-5 days. The mortality rate of the larvae was calculated by the following equation, and the results are shown in Tables 4 and 5.

[Equation 4]

Larval mortality = (number of dead larvae) / (number of test larvae) x 100

Insecticidal Effects of Rice Plants on Chilo Suprelessis by Irrigating Soil with Pesticide Solution compound Application amount mg / plant Mortality rate after 4 days,% Compound (I-1) 0.01 30 Clotianidine 0.001 10 Compound (I-1) + Clotianidine 0.01+ 0.001 70 * 37 ** fist : * ; Activity (real effect) found by the combination of two kinds of compounds **; Activity calculated by the Colby equation (expected effect)

compound Application amount mg / plant Mortality rate after 5 days,% Compound (I-5) 0.15 5 Dinotefuran 0.44 0 Compound (I-5) + Dinotefuran 0.15 + 0.44 55 * 5 ** fist : * ; Activity (real effect) found by the combination of two kinds of compounds **; Activity calculated by the Colby equation (expected effect)

As shown in Table 4, it has been found that Compound (I-1), when used as a mixture with clotianidine, results in a greater pesticidal effect than would be expected when used alone, and mixed Synergistic effects were observed.

As shown in Table 5, it was found that Compound (I-5), when used as a mixture with dinotefuran, results in a greater pesticidal effect than would be expected when used alone. Synergistic effects were observed.

Test Example 4: flu through the soil drench treatment with the insecticide solution telra Insecticidal effect on Stella (Plutella xylostella) in xylene

The test compound was dissolved by adding acetone containing 5% Tween 20 (trade name) at a rate of 0.1 ml per 1 mg of test compound, and the solution was diluted with ion-exchanged water to a total volume of 3 ml. Each prepared pesticidal solution was irrigated onto the surface of plant root soil for cabbage plants grown in a cell tray (with 24 ml of soil space). After 4 days, cut out the ground-upper part of the plant and put it in a plastic cup, in it a flutella Ten xylostella two larvae were released. The cup was placed in a culture chamber controlled to constant temperature (25 ° C.) and the number of live larvae was counted after 4 days. The mortality rate of the larvae was calculated by the following equation, and the results are shown in Tables 6 and 7.

[Equation 5]

Larval mortality = (number of dead larvae) / (number of test larvae) x 100

Flu through Joowon irrigation treatment with pesticidal solution telra Insecticidal effect on the cabbage plants with about Stella Giles compound Application amount mg / plant Mortality rate after 4 days,% Compound (I-2) 0.0016 0 Dinotefuran 0.0016 0 Compound (I-2) + Dinotefuran 0.0016 + 0.0016 60 * 0** fist : * ; Activity (real effect) found by the combination of two kinds of compounds **; Activity calculated by the Colby equation (expected effect)

compound Application amount mg / plant Mortality rate after 4 days,% Compound (I-3) 0.04 50 Dinotefuran 0.04 10 Compound (I-3) + Dinotefuran 0.04 + 0.04 80 * 55 ** fist : * ; Activity (real effect) found by the combination of two kinds of compounds **; Activity calculated by the Colby equation (expected effect)

As shown in Table 6, it has been found that Compound (I-2), when used as a mixture with dinotefuran, results in a greater pesticidal effect than would be expected when used alone. Synergistic effects were observed.

As shown in Table 7, it has been found that Compound (I-3), when used as a mixture with dinotefuran, results in a greater pesticidal effect than would be expected when used alone. Synergistic effects were observed.

Test Example 5: Fluteella through immersion treatment of bait crop Insecticidal effect on Stella (Plutella xylostella) in xylene

A pesticide solution was prepared by dissolving the test compound by adding acetone containing 5% of Tween 20 (trade name) at a rate of 0.1 ml per mg of test compound, and diluting the solution to a predetermined concentration with a 5,000-fold diluted DAIN aqueous solution. It was. Cabbage leaves were cut off at the tip of the leaf and immersed in the pesticide solution for several seconds. After the solution was dried, the leaves were placed in an ice cream cup (with 180 ml of space) and 10 flutes la xylostella 2-larvae were released therein. The cup was placed in a culture chamber controlled to constant temperature (25 ° C.) and the number of live larvae was counted after 4 days. The mortality rate of the larvae was calculated by the following equation, and the results are shown in Table 8.

[Equation 6]

Larval mortality = (number of dead larvae) / (number of test larvae) x 100

compound Application amount mg / plant Mortality rate after 4 days,% Compound (I-4) 0.0064 15 Thiamethoxam 0.0064 10 Compound (I-4) + Tiamethoxam 0.0064 + 0.0064 50 * 23.5 ** fist : * ; Activity (real effect) found by the combination of two kinds of compounds **; Activity calculated by the Colby equation (expected effect)

As shown in Table 8, Compound (I-4), when used as a mixture with thiamethoxam, was found to cause greater insecticidal effects than when used alone, and synergistic effects from mixing were observed. It became.

The compositions of the present invention can be used as insecticides for agricultural and horticultural applications.

Claims (13)

Insecticide composition containing the 1 type (s) or 2 or more types of compound chosen from the compound represented by the following general formula [I] or its salt, and the neonicotinoid type compound represented by the following general formula [II]: [Formula I]

(Wherein, R ¹ , R ² , R ³ And R ⁴ It is the same or different, each represent a hydrogen atom, C _{1 -6} alkyl group, C _{1 ~ 6} haloalkyl group or a halogen atom; R ⁵ Is a hydrogen atom or a C _{1 -6} alkyl group; X is CH or N; n is 0 to 3), [Formula II]

[Wherein Y is CH ₂ , S or NR ⁶ (R ⁶ Is a hydrogen atom or a C _{1 -6} alkyl group) and; Z is N or CH; W is cyano or nitro group; A and B are the same or different, and each is taken represents a hydrogen atom or a C _{1 -6} alkyl group, or together with the adjacent Y, C and N to form a ring represented by the formula:

Wherein ring [A] is a group represented by the formula:

In which R ⁶ Is as defined above; R ⁷ Is a hydrogen atom or a C _{1 -6} alkyl group)}, the formula:

Represents a heterocyclic group selected from pyridyl, thiazolyl and tetrahydrofuryl groups, said heterocyclic ring optionally substituted by 1 to 3 halogen atoms. The insecticide composition according to claim 1, wherein the compound represented by the formula [I] is a compound represented by the following formula [Ia]: [Formula Ia]

In which the symbols are as defined above. A compound according to claim 2, wherein in the compound represented by the formula [Ia], R ¹ Is a halogen atom or a C _{1 -6} haloalkyl group, R ² Is a halogen atom, R ³ And R ⁵ Each is a C _{1 -6} alkyl group, R ⁴ Is a hydrogen or halogen atom, and X is N. A compound according to claim 2, wherein in the compound represented by the formula [Ia], R ¹ Is a chlorine atom or bromine atom or a trifluoromethyl group, R ² Is a chlorine atom, R ³ Is a methyl group, R ⁵ Is isopropyl group, R ⁴ Is a hydrogen or chlorine atom, and X is N. 3. A compound according to claim 2, wherein the compound represented by formula [la] is 2- [1- (3-chloropyridin-2-yl) -3-trifluoromethylpyrazol-5-ylcarbonylamino] -N-iso Propyl-3-methylbenzamide, 5-chloro-2- [1- (3-chloropyridin-2-yl) -3-trifluoromethylpyrazol-5-ylcarbonylamino] -N-isopropyl- 3-methylbenzamide, 2- [1- (3-chloropyridin-2-yl) -3-chloropyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 5-chloro -2- [1- (3-chloropyridin-2-yl) -3-chloropyrazol-5-ylcarbonylamino] -N-isopropyl-3-methylbenzamide, 2- [3-bromo- 1- (3-chloropyridin-2-yl) pyrazol-5-yl-carbonylamino] -N-isopropyl-3-methylbenzamide or 2- [3-bromo-1- (3-chloropyridine -2-yl) pyrazol-5-ylcarbonylamino] -5-chloro-N-isopropyl-3-methylbenzamide. The neonicotinoid compound represented by the formula [II] is selected from the group consisting of clothianidine, nitenpyram, imidacloprid, thiacloprid, thiamethoxam, acetamiprid, Insecticide composition which is dinotefuran. The insecticide composition according to any one of claims 1 to 5, wherein the neo nicotinoid compound represented by the formula [II] is clotianidine. A pest control method comprising applying the pesticide composition according to any one of claims 1 to 7 to a position other than a site where the pest directly harms. Two kinds of compounds, i.e., compounds represented by the formula [I] according to any one of claims 1 to 7, for a period ranging from sowing to seedling-growing for crops grown by the seedling-planting method. Or a salt thereof and the neonicotinoid compound represented by the formula [II], and then irrigation to the seedling soil in the form of a mixed solution or to the seedling soil in the form of mixed granules. Pest control method. Two kinds of compounds, i.e., compounds represented by the formula [I] according to any one of claims 1 to 7, for a period ranging from sowing to seedling-growing for crops grown by the seedling-planting method. Or cultivating seedlings using the seedling soil containing the salt thereof and the neonicotinoid compound represented by the formula [II] in the seedling soil. Two kinds of compounds, i.e., compounds represented by the formula [I] according to any one of claims 1 to 7, for a period ranging from seedling-planting to growth for crops grown by the seedling-planting method. Or a salt thereof and a neonicotinoid compound represented by the formula [II] for irrigation treatment, planting-hole treatment, planting-hole treated soil incorporation, or plant-root treatment. Or spraying in the soil of the main fabric through plant-root treated soil incorporation. In the case of crops grown by planting or seeding seeds, seed potatoes or bulbs directly on the main fabric, two kinds of compounds, namely the compounds represented by the formula [I] according to any one of claims 1 to 7, or salts thereof; A pest control method comprising a sonication of seeds, seed potatoes or bulbs, dusting or coating with a neonicotinoid compound represented by the formula [II]. During the growing period of a crop grown by planting or seeding seeds, seed potatoes or bulbs directly on the main fabric, two kinds of compounds, ie compounds represented by the formula [I] according to any one of claims 1 to 7, or their A pest and pest control method comprising treating the soil of the main fabric by irrigation, main source treatment or main source treatment soil incorporation with a salt and a neonicotinoid compound represented by the formula [II].