KR20060136466A - Aqueous dispersions of silicone polyether block copolymers - Google Patents

Abstract

(AB) Described are water dispersions of _n silicone polyether block copolymers, methods of making dispersion compositions, and formulations for personal care, home care and health care containing the composition. The aqueous dispersion may be a vesicle or emulsion composition, depending on the (AB) _n silicone polyether block copolymer structure and the method of making the dispersion.

Aqueous dispersion, (AB) n silicone polyether block copolymer, vesicle, latex composition

Description

Aqueous dispersions of silicone polyether block copolymers

Reference to related application

This application is incorporated by reference in U.S. Patent Application No. 60 / 563,663, filed April 20, 2004, U.S. Patent Application No. 60 / 611,258, filed September 17, 2004, and U.S. Patent Application, filed September 17, 2004. Claims priority to US 60 / 611,151 and US Patent Application No. 60 / 611,229, filed September 17, 2004.

The present application relates to a water dispersion of the (AB) _n silicone polyether block copolymer, a method for preparing the water dispersion, and a formulation for personal care, home care and health care containing the water dispersion. The aqueous dispersion may be a vesicle or an emulsion composition depending on the structure of the (AB) _n silicone polyether block copolymer and the method for producing the dispersion.

Silicone surfactants have been designed for various applications by combining hydrophobic organopolysiloxanes with various hydrophilic moieties. For example, silicone surfactants known as silicone polyethers (SPEs) are based on the copolymer structure of polyorganosiloxanes having pendant polyoxyalkylene groups. Most commonly, the copolymer structure of the silicone polyether is of the "rake" type, in which case the linear polyorganosiloxane is mainly composed of copolymer compositions in which the pendant polyoxyalkylene groups form a "rake". To provide a "backbone". "ABA" structures are also common, in which case pendant polyoxyalkylene groups are located at each molecular terminus of the linear polyorganosiloxane. Also known are (AB) _n silicone polyethers, in which blocks of siloxane units and polyether units are repeated to form a copolymer. (AB) _n SPE is not as prominent in the art as Lake type or ABA type silicone polyethers. For example, there are a number of teachings describing various rake and ABA type silicone polyether structures for use as emulsifiers, wetting agents, and multipurpose aqueous surfactants in many personal care, home care, and health care compositions. . Recently, the coagulation behavior of rake type and ABA type silicone polyethers has been reported.

There is a long-standing need in the cosmetics and drug formulation / delivery fields to identify vesicle compositions that can readily form and capture active ingredients and are stable under a variety of chemical and mechanical stresses and can deliver the active materials under controlled conditions in a controlled manner. The vesicles derived from silicone surfactants, more particularly silicone polyether surfactants, are noted because of the additional inherent advantages of this class of surfactants over other types of surfactants. For example, silicone polyether surfactants often have improved aesthetic properties in personal care formulations.

US Pat. Nos. 5,364,633 and 5,411,744 to Hill teach self-assembly of silicone vesicles in water dispersions of some silicone polyethers. Lin International Application No. PCT / US03 / 38455 teaches the capture of various oils in silicone vesicles and their use in various personal care formulations.

We have found that certain (AB) _n silicone polyethers form a unique dispersion in an aqueous medium. In one embodiment, several (AB) _n SPE structures defined form a vesicle composition in an aqueous medium. As a second aspect, some (AB) _n SPE structures form a stable dispersion that can be used to prepare the emulsion. These stable dispersions and vesicles can be used to formulate compositions for delivering pharmaceutically active ingredients and personal care active ingredients.

(AB) Although _n silicone polyether block copolymers are known, the choice of specific structures or some molecular modifications that allow the copolymer to form a stable dispersion in an aqueous medium is not known until now.

Summary of the Invention

The present invention relates to an aqueous composition having dispersed particles, wherein the dispersed particles are (AB) _n block silicon of the formula-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z- Polyether copolymers wherein x and y are greater than 4, m is 2 to 4, z is greater than 2, R is independently a monovalent organic group, and R ¹ is a divalent hydrocarbon of 2 to 30 carbon atoms It relates to an aqueous composition comprising a).

The invention also relates to (AB) _n block silicone polyether copolymers (A) of the formula-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z- x and y are greater than 4, m is 2 to 4, z is greater than 2, R is independently a monovalent organic group, R ¹ is a divalent hydrocarbon having 2 to 30 carbon atoms) and any water miscibility Combining the volatile solvent (B) with water to form an aqueous dispersion (I), and mixing the aqueous dispersion to form dispersed particles of (AB) _n silicone polyether copolymer having an average particle size of 10 μm (II) And optionally (III) removing the water miscible volatile solvent from the water dispersion.

The invention also relates to (AB) _n block silicone polyether copolymers (A) of the formula-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z- x and y are greater than 4, m is 2 to 4, z is greater than 2, R is independently a monovalent organic group, and R ¹ is a divalent hydrocarbon of 2 to 30 carbon atoms). Preparation of an aqueous continuous phase emulsion with an average particle size of less than 10 μm, comprising mixing with (B) to form a hydrophobic phase (I) and adding water to the hydrophobic phase to form a water continuous phase emulsion (II). It is about a method.

The present invention also relates to personal care, home care and health care formulations containing the aqueous composition.

The present invention provides an aqueous composition having dispersed particles, wherein the dispersed particles comprise an (AB) _n block silicone polyether copolymer of formula (I).

-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z-

In Formula I above,

x and y are greater than 4

m is 2 to 4,

z is greater than 2,

R is independently a monovalent organic group,

R ¹ is a divalent hydrocarbon having 2 to 30 carbon atoms.

The siloxane blocks in the above formula (I) are mainly linear siloxane polymers of the formula (R ₂ SiO) _x where R is independently selected from monovalent organic groups and x is an integer greater than 4. In a first embodiment, the x value (ie degree of polymerization, DP) of the polysiloxane chain is in the range of 20 to 100, or 30 to 75. These structures form vesicles in an aqueous medium, as discussed below. In a second embodiment, the range of x values is 5 to 19, or 5 to 15. These structures also form a stable emulsion in an aqueous medium having a particle size of 10 μm, as discussed below.

The organic group represented by R in the siloxane polymer is free of aliphatic unsaturation. These organic groups can be independently selected from monovalent hydrocarbons and monovalent halogenated hydrocarbon groups without aliphatic unsaturation. The monovalent group has 1 to 20, or 1 to 10 carbon atoms, examples of which include alkyl groups such as methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, undecyl and octadecyl; Cycloalkyl, such as cyclohexyl; Cycloalkyl such as phenyl, tolyl, xylyl, benzyl and 2-phenylethyl; And halogenated hydrocarbon groups such as 3,3,3-trifluoropropyl, 3-chloropropyl and dichlorophenyl. At least 50%, or at least 80% of the organic groups without aliphatic unsaturation in the organopolysiloxane may be methyl (denoted Me). Typically, the siloxane blocks are mainly linear polydimethylsiloxanes of the formula (Me ₂ SiO) _x where x is as defined above.

The polyoxyalkylene block of the silicone polyether is a block of the formula (C _m H _2m O) _y where m is 2 to 4 and y can be greater than 4 or 5 to 45, or 5 to 25. . Polyoxyalkylene blocks typically comprise oxyethylene units (C ₂ H ₄ O) _y , oxypropylene units (C ₃ H ₆ O) _y , oxybutylene units (C ₄ H ₈ O) _y or mixtures thereof. can do. Typically, the polyoxyalkylene block comprises oxyethylene units (C ₂ H ₄ O) _y .

At least one terminal of each polyoxyalkylene block in formula (I) is bonded to the siloxane block by a divalent organic group represented by R ¹ . This bond is determined by the reaction used to prepare the (AB) _n block silicone polyether copolymer. The divalent organic group of R ¹ may be independently selected from a divalent hydrocarbon having 2 to 30 carbon atoms and a divalent organic functional hydrocarbon having 2 to 30 carbon atoms. Typical and non-limiting examples of divalent hydrocarbon groups include ethylene, propylene, butylene, pentylene, hexylene, heptylene, octylene and the like. Typical and non-limiting examples of divalent organofunctional hydrocarbon groups include acrylates and methacrylates. Typically, R ¹ is propylene (-CH ₂ CH ₂ CH _2- ).

(AB) The _n block silicone polyether is terminated. The terminal blocking unit is also determined by the reaction used to prepare the (AB) _n block silicone polyether copolymer, which is generally the residual reactive group of the reactants used. For example, (AB) _n block silicone polyether copolymers are prepared by metal catalyzed hydrosilylation reactions of diallyl polyethers (ie, allyl groups are present in each molecular group) with SiH terminated polyorganosiloxanes. Can be. The resulting (AB) _n- block silicone polyether copolymer has a polyoxyalkylene block bonded to the silicon block via a propyleneoxy group (-CH ₂ CH ₂ CH ₂ O-), and slightly molar excess of allyl polyether By use, allyl endblocking units (-CH ₂ CHCH ₂ ) are produced. Another endblocking unit can be produced by adding another molecule to the reaction used to prepare the (AB) _n block silicone polyether copolymer, which can react with the siloxane or polyether block intermediate. For example, the (AB) _n- block silicone polyether copolymer can be end capped with an organic compound by the addition of an organic compound having monoterminated aliphatic unsaturation, such as monoallyl terminated polyether. Typically, the terminal blocking units of (AB) _n block silicone polyethers are allyl ether (CH ₂ = CHCH ₂ O—) or allyl polyether.

(AB) The molecular weight of the _n block silicone polyether copolymer is determined by the number of repeating siloxane and polyoxyalkylene blocks, represented by the subscript z in formula (I). Typically, the z value is such that the weight average molecular weight (M _w ) is in the range of 1,500 to 150,000, or 10,000 to 100,000.

(AB) The ratio of silicon blocks to polyoxyalkylene blocks in _n SPE can also be used to identify structures that form vesicles or stable aqueous emulsions. This molecular parameter is represented by the value of x / (x + y) in formula (I). The value of x / (x + y) may vary from 0.2 to 0.9, or 0.4 to 0.9.

The (AB) _n SPEs of the invention can be prepared by any method known in the art for preparing such block copolymers. In addition, (AB) _n SPE of the present invention is prepared according to the method described below.

The invention also relates to SiH terminated organopolysiloxanes (a), polyoxyalkylenes (b) having unsaturated hydrocarbon groups at their respective molecular ends, hydrosilylation catalysts (c), optionally solvents (d) and optionally mono terminal unsaturated A process for preparing an (AB) _n- block silicone polyether copolymer comprising reacting an organic endblocker compound (e) having a hydrocarbon group, characterized in that the molar ratio of unsaturated organic group to SiH in the reaction is at least 1: 1. Provide a way to.

"Compound (where, M 'method SiH terminated organopolysiloxane useful in the present invention has the formula M'DM of the formula R ₂ HSiO _1/2 and a siloxane unit, D is a siloxane unit of formula R ₂ SiO _2/2 R is independently a monovalent organic group as defined above). Typically, the SiH terminated organopolysiloxane is a dimethylhydrogensiloxy terminated polydimethylsiloxane of formula Me ₂ HSiO (Me ₂ SiO) _× SiHMe ₂ , where x is as defined above. SiH terminated organopolysiloxanes and methods for their preparation are well known in the art.

Polyoxyalkylenes useful in the process of the present invention may be polyoxyethylene comprising units of the _formula- (C ₂ H ₄ O) _y- , where y is as defined above, each molecular chain end ( Ie, at the α and ω positions). Unsaturated organic groups can be unsaturated hydrocarbon groups such as alkenyl or alkynyl groups. Examples of typical, non-limiting alkenyl groups are shown in the following structures: H ₂ C═CH—, H ₂ C═CHCH ₂ —, H ₂ C═C (CH ₃ ) CH ₂ —, H ₂ C═ CHCH ₂ CH ₂ —, H ₂ C═CHCH ₂ CH ₂ CH ₂ — and H ₂ C═CHCH ₂ CH ₂ CH ₂ CH ₂ —. Examples of typical and non-limiting alkynyl groups are shown in the following structures: HC≡C-, HC≡CCH _2- , HC≡CC (CH ₃ )-, HC≡CC (CH ₃ ) _2- , HC≡ CC (CH ₃ ) ₂ CH _2- . Polyoxyethylenes having unsaturated hydrocarbon groups at the end of each molecule are known in the art and many are commercially available. The unsaturated organic group may also be an organofunctional hydrocarbon such as acrylate, methacrylate and the like. Typically, polyoxyethylene is a compound of the formula H ₂ C═CHCH ₂ O (CH ₂ CH ₂ O) _y CH ₂ CH═CH ₂ , wherein y is greater than 4, 5 to 30, or 5 to 22 )to be.

SiH terminated organopolysiloxanes having unsaturated organic groups at each molecular end and polyoxyalkylene are reacted in the presence of hydrosilylation catalysts known in the art. Examples of such hydrosilylation catalysts are all metal containing catalysts which promote the reaction of silicon-bonded hydrogen atoms of SiH terminated organopolysiloxanes with unsaturated hydrocarbon groups on polyoxyethylene. Examples of metals are ruthenium, rhodium, palladium, osmium, iridium or platinum.

Hydrosilylation catalysts include: chloroplatinic acid, alcohol-modified platinum chloride, olefin complexes of chloroplatinic acid, complexes of chloroplatinic acid and divinyltetramethyldisiloxane, fine platinum particles adsorbed on carbon carriers, supported on metal oxide carriers Platinum halides exemplified by platinum (e.g. Pt (Al ₂ O ₃ )), platinum black, platinum acetylacetonate, platinum (divinyltetramethyldisiloxane), PtCl ₂ and PtCl ₄ , Pt (CN) ₂ , platinum halides And complexes with unsaturated compounds such as ethylene, propylene and organovinylsiloxane, styrene hexamethyldiplatinum and RhCl ₃ (Bu ₂ S) ₃ .

The amount of hydrosilylation catalyst used is not narrowly limited as long as it is present in an amount that catalyzes the reaction of SiH terminated organopolysiloxane with polyoxyethylene having an unsaturated hydrocarbon group at each molecular end at room temperature or higher than room temperature. The exact required amount of such catalyst will depend on the specific catalyst used and is not easily estimated. However, in the case of platinum containing catalysts, the amount may be as low as 1 part by weight of platinum per million parts by weight of the components, i.e., polyoxyethylene having unsaturated hydrocarbon groups at each molecular end and SiH terminated organopolysiloxane. The catalyst can be added at 10 to 120 parts by weight per component, i.e., polyoxyethylene having unsaturated organic groups at each molecular terminus and SiH terminated organopolysiloxane, but typically poly having unsaturated organic groups at each molecular terminus. Oxyethylene and SiH terminated organopolysiloxane are added in an amount of 10 to 60 parts by weight per million parts.

The hydrosilylation reaction can be carried out in the pure state or in the presence of solvent (d). The solvent may be an alcohol such as methanol, ethanol, isopropanol, butanol or n-propanol; Ketones such as acetone, methyl ethyl ketone or methyl isobutyl ketone; Aromatic hydrocarbons such as benzene, toluene or xylene; Aliphatic hydrocarbons such as heptane, hexane or octane; Glycols such as propylene glycol methyl ether, dipropylene glycol methyl ether, propylene glycol n-butyl ether, propylene glycol n-propyl ether or ethylene glycol n-butyl ether; Halogenated hydrocarbons such as dichloromethane, 1,1,1-trichloroethane or methylene chloride; Chloroform, dimethyl sulfoxide, dimethyl formamide, acetonitrile, tetrahydrofuran, white oil, mineral or naphtha.

The amount of solvent may be up to 50% by weight, based on the total weight of the components in the hydrosilylation reaction, but is typically 20 to 50% by weight. The solvent used during the hydrosilylation reaction can subsequently be removed from the silicone polyethers produced by various known methods.

Additional components known to promote this reaction can be added to the hydrosilylation reaction. These components include salts such as sodium acetate which have a buffering effect with the platinum catalyst.

In a first aspect of the invention, the (AB) n SPE of formula (I) has an x value (ie, the degree of polymerization of the polysiloxane chains in the siloxane units, DP) of from 20 to 100, or from 30 to 75. These structures form vesicles in an aqueous medium. Such vesicle compositions can be prepared by mixing (AB) _n SPE with water using all methods known in the art to prepare vesicle compositions. The type and extent of the mixing method depends on the specific structure of the selected (AB) _n SPE. For example, some (AB) _n SPEs spontaneously form vesicle compositions when mixed with water, while some (AB) _n SPEs may be any water soluble solvent (described below) to facilitate the formation of vesicles. Requires the presence of component (B)).

Optional component (B) is a water miscible volatile solvent. As used herein, "water miscible" means that the solvent forms a dispersion with water at room temperature for at least several hours. "Volatile" means that the solvent has a higher vapor pressure than water at various temperatures. As such, when the aqueous dispersion of organopolysiloxane and solvent is subjected to conditions that remove the solvent (eg, the dispersion is heated under reduced pressure), the solvent is primarily removed so that all or most of the water remains in the composition.

Suitable water miscible volatile solvents as component (B) include organic solvents such as alcohols, ether glycols, esters, acids, halogenated hydrocarbons, diols. The organic solvent must be miscible with water in order to effectively disperse the silicone and to maintain a stable and homogeneous dispersion outside the defined time. Examples of water miscible alcohols include methanol, ethanol, propanol, isopropanol, butanol and higher hydrocarbon alcohols, and glycols include glycol ether, methyl-ethyl ether, methyl isobutyl ether (MIBK), and esters of triglycerol Esters, and esterification products of acids and alcohols, and halogenated hydrocarbons include chloroform. Typically, water miscible organic solvents are solvents having a relatively low boiling point (<100 ° C.) or high evaporation rates so that they can be easily removed under vacuum. Most preferred water miscible solvents in the present invention are volatile alcohols including methanol, ethanol, isopropanol and propanol. These alcohols may be removed from the aqueous mixture containing the silicone dispersion via vacuum stripping at ambient temperature.

The aqueous composition may also optionally comprise silicone or organic oils as component (C). The silicone may be an organopolysiloxane of the formula R _i SiO _{(4-i) / 2} , where i has an average value of 0 to 3 and R is a monovalent organic group. Organopolysiloxanes can be cyclic, linear, branched, and mixtures thereof.

Component (C) may be a volatile methyl siloxane (VMS) comprising low molecular weight linear and cyclic volatile methyl siloxanes. Volatile methyl siloxanes that meet the CTFA definition of cyclomethicone are considered to be within the definition of low molecular weight siloxanes.

If component (C) is an organic oil, it may be selected from organic oils known in the art suitable for use in personal care, home care or health care formulations. Suitable organic oils include natural oils such as coconut oil; Hydrocarbons such as mineral oil and hydrogenated polyisobutenes; Fatty alcohols such as octyldodecanol; Esters such as C12-C15 alkyl benzoate; Diesters such as propylene dipellaganate; There are triesters such as glyceryl trioctanoate, but are not limited to these. The organic oil component may also be a mixture of low and high viscosity oils. Suitable low viscosity oils have a viscosity of 5 to 100 mPa · s at 25 ° C. and are generally esters of the formula RCO—OR ′ wherein RCO is a carboxylic acid radical and OR ′ is an alcohol moiety. Examples of low viscosity oils include isotridecyl isononanoate, PEG-4 diheptanoate, isostearyl neopentanoate, tridecyl neopentanoate, cetyl octanoate, cetyl palmitate, cetyl ricinolate, Cetyl stearate, cetyl myristate, coco-dicaprylate / caprate, decyl isostearate, isodecyl oleate, isodecyl neopentanoate, isohexyl neopentanoate, octyl palmitate, dioctyl maleate, Tridecyl octanoate, myristyl myristate, a mixture of octodocanol or octyldodecanol, acetylated lanolin alcohols, cetyl acetate, isododecanol, polyglyceryl-3-diisostearate or mixtures thereof There is this. High viscosity surface oils generally have a boiling point of 200 to 1,000,000, preferably 100,000 to 150,000 mPa · s at 25 ° C. Surface oils include castor oil, lanolin and lanolin derivatives, triisocetyl citrate, sorbitan sesquinolate, C10-C18 triglycerides, caprylic / capric acid / triglycerides, coconut oil, corn oil, cottonseed oil, Glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, glyceryl trioctanoate, hydrogenated castor oil, linseed oil, mink oil, olive oil, palm oil, illipe butter, rapeseed oil, soybean oil Sunflower seed oil, tallow, tricaphrine, trihydroxystearin, triisostealine, trilaurin, trilinolein, trimyristin, triolein, tripalmitin, tristealine, walnut oil, malt oil, cholesterol or Mixtures thereof. Mineral oils such as liquid paraffin or liquid petroleum, among any other non-silicone fatty substances; Animal oils such as perhydrosqualene or arara oil; Or vegetable oils such as sweet almonds, carlofilum, palm, castor, avocado, jojoba, olive or whole grain germ oil. Esters of ranolic acid, oleic acid, lauric acid, stearic acid or myristic acid with alcohols such as, for example, oleyl alcohol, linoleyl or linoleyl alcohol, isostearyl alcohol or octyldodecanol; Or acetylglycerides, octanoate, decanoate or ricinoleate of alcohols or polyalcohols may also be used. Hydrogenated oils which are solid at 25 ° C., for example hydrogenated castor oil, palm oil or coconut oil or hydrogenated tallow at 25 ° C .; Mono-, di-, tri- or sucroglycerides; Lanolin or fatty esters can be used.

Formation of vesicles in the compositions of the present invention can be identified by conventional techniques at the state of the art. Typically, the vesicles have a lamellar structure that exhibits birefringence when irradiated with a cross polarization microscope. Formation of vesicles can also be demonstrated by Cyro-transmission electron microscopy (Cryo-TEM) technology. Particle size measurements can also be used to indicate that the organopolysiloxane is sufficiently dispersed in a conventional aqueous medium of vesicle size. For example, an average particle size of 0.500 μm is typical for dispersed vesicles. A vesicle with an average particle size of less than 0.200 μm, or 0.100 μm is possible in the present invention.

(AB) The amount of _n- block silicone polyether copolymer (component (A)), any water miscible volatile solvent (component (B)) and water may vary in the compositions of the present invention but typically the amount of component (A) is 2 To 50 weight percent, or 2 to 25 weight percent, or 2 to 15 weight percent, and the amount of component (B) is 0 to 50 weight percent, or 2 to 30 weight percent, or 2 to 20 weight percent, and component (C ) Is 0 to 50% by weight, or 1 to 20% by weight, or 2 to 10% by weight, and the amount of water is such that the total of component (A), component (B) and water is 100% by weight.

In addition, vesicle compositions can be prepared according to the methods of the present invention discussed below.

The invention also relates to (AB) _n block silicone polyether copolymers (A) of the formula-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z- x and y are greater than 4, m is 2 to 4, z is greater than 2, R is independently a monovalent organic group, R ¹ is a divalent hydrocarbon having 2 to 30 carbon atoms) and any water miscibility Combining volatile solvent (B) with water to form a water dispersion (I), mixing the water dispersion to form dispersed particles of (AB) _n silicone polyether copolymer having an average particle size of less than 10 μm (II) and optionally (III) removing the water miscible volatile solvent from the water dispersion.

Step (I) comprises combining (AB) n SPE as component (A) and a water miscible volatile solvent as optional component (B). Component (A) and component (B) in step (I) are the same as described above. The amount of component (A), component (B) and water combined in step (I) may vary in the process, but typically the amount of component (A) is from 2 to 50% by weight, or from 2 to 25% by weight, or from 2 to 15 % By weight, component (B) is from 0 to 50% by weight, or from 2 to 30% by weight, or from 2 to 20% by weight, and the amount of water is 100% by weight in total of component (A), component (B) and water. The amount to make it possible.

Step (II) in the above process is to mix the water dispersion formed in step (I) to form dispersed particles of (AB) _n silicone polyether copolymer having an average particle size of less than 10 μm. No special requirements or conditions are necessary to carry out the mixing of step (II). Mixing techniques can be simple stirring, homogenization, sonalating and other mixing techniques known in the art. Mixing can be carried out in a batch, semicontinuous or continuous process.

Step (III) in the above process involves the removal of an optional and water miscible volatile solvent (component (B)). Typically, the water miscible volatile solvent is removed by techniques known in the art, for example by applying the vesicle composition to reduced pressure with optional heating of the composition. Exemplary devices of this technology include rotary evaporators and thin film strippers.

In a second aspect of the invention, the (AB) n SPE of formula (I) has an x value (ie, the degree of polymerization of the polysiloxane chains in the siloxane units, DP) of from 5 to 19, or from 5 to 10. These structures form a stable emulsion in an aqueous medium with a particle size of less than 10 μm. Stable emulsions may be prepared by mixing (AB) n SPE of the second aspect with water according to known techniques for producing several continuous phase emulsions. In addition, the emulsion compositions may be prepared according to the methods of the present invention discussed below.

Accordingly, the present invention relates to (AB) _n block silicone polyether copolymers (A) of the formula-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z- , x and y are greater than 4, m is 2 to 4, z is greater than 2, R is independently a monovalent organic group, and R ¹ is a divalent hydrocarbon having 2 to 30 carbon atoms) A water continuous phase having an average particle size of less than 10 μm, comprising the step of mixing the chemical conversion volatile solvent (B) to form a hydrophobic phase (I) and adding water to the hydrophobic phase to form a water continuous phase emulsion (II) Provided is a method for preparing an emulsion.

In step (II) of the above process, (AB) n SPE as component (A) and water miscible volatile solvent as component (B) are the same as described above.

After forming a hydrophobic phase of component (A) and component (B), water is added to the mixture in step (II) of the process to prepare a water continuous phase emulsion. After mixing component (A) and component (B) in step (I), no special requirements or conditions are required for mixing with water in step (II). The mixing and water addition steps can be carried out in a batch, semicontinuous or continuous process.

The hydrophobic phase of step (I) may also comprise silicone or organic oil as component (C), as described above.

The hydrophobic phase of step (I) may optionally also comprise an active ingredient for personal care, home care or health care. Possible personal care, home care or health care ingredients are taught in WO 03/101412, incorporated herein by reference. Personal care or health care ingredients may also be selected from personal care or health care "active ingredients", ie compounds known to have cosmetic and / or pharmaceutical activity. Typical personal care or health care active ingredients are described in US Pat. No. 6,168,782, which is incorporated herein by reference. U.S. Patent No. 5,948,855 (September 7, 1999) by General Assignee also includes an extensive list of some suitable oil soluble active ingredients such as vitamins and drugs that can be used as oil phase in oil-in-water emulsions, among which vitamins Examples include, but are not limited to, vitamin A ₁ , retinol, C ₂ -C ₁₈ esters of retinol, vitamin E, tocopherol, esters of vitamin E, and mixtures thereof. Retinols include trans-retinol, 13-cis-retinol, 11-cis-retinol, 9-cis-retinol and 3,4-didehydro-retinol. Other suitable vitamins include retinyl acetate, retinyl palmitate, retinyl propionate, α-tocopherol, tocophersolan, tocopheryl acetate, tocopheryl linolate, tocopheryl nicotinate and tocopheryl succinate.

The amount of component (A), component (B), component (C) and component (D) may vary in the process of preparing the emulsion of the invention, but typically the amount of component (A) is from 2 to 60% by weight, or 2 To 50% by weight, or 2 to 40% by weight, the amount of component (B) is 0 to 50% by weight, or 2 to 30% by weight, or 2 to 20% by weight, and the amount of component (C) is 0 to 30% by weight. %, Or 0 to 25% by weight, or 0 to 20% by weight, the amount of component (D) is 0 to 30% by weight, or 0 to 25% by weight, or 0 to 20% by weight, and the amount of water is component (A) The amount is such that the total of components (B), (C), (D) and water is 100% by weight.

The invention also relates to a vesicle composition further comprising a personal care, home care or health care ingredient. Thus, the vesicle composition can be used to capture and deliver post-application applications for personal care, home care or health care ingredients. Possible personal care, home care or health care ingredients are taught in WO 03/101412, incorporated herein by reference. Personal care or health care ingredients may also be selected from personal care or health care "active substances", ie compounds known to have cosmetic and / or pharmaceutical activity. Typical personal care or health care actives are described in US Pat. No. 6,168,782, which is incorporated herein by reference.

Compositions prepared according to the present invention can be used in a variety of general marketable (OTC) personal care compositions, health care compositions, and home care compositions. Therefore, they may be used as limiting agents, deodorants, skin creams, skin care creams, humectants, facial treatments (such as acne or wrinkle removers), body and facial cleansers, bath oils, perfumes, lotions, sachets, sunscreen, before and after shave lotions, liquids Soap, Shaving Soap, Shaving Soap, Hair Shampoo, Hair Conditioner, Hair Spray, Mousse, Perfume, Depilatory, Hair Cuticle, Makeup, Tone Makeup, Foundation, Blush, Lipstick, Lip Balm, Eyeliner, Mascara, Oil Remover , Color makeup remover, nail polish and powder.

The following examples are intended to further illustrate the compositions and methods of the present invention and should not be considered as limiting the present invention. Unless otherwise indicated, all parts and percentages in the examples are by weight and all measurements are taken at 25 ° C.

matter

The typical (AB) _n silicone polyethers represented herein as (AB) _n SPE, used in the emulsion composition of the present invention, are M'D _x M 'siloxanes (dimethyl-hydrogen terminated (Me ₂ ) with varying degrees of polymerization (x). HSiO) α, ω-diallyl of linear polysiloxanes (prepared using well-known siloxane polymerization techniques) and allyl terminated polyethers (CH ₂ = CHCH ₂ O (CH ₂ CH ₂ O) _m CH ₂ CH = CH ₂ Oxy polyether) polyglycol AA600, AA1200 and AA2000 containing on average 12, 25 and 44 ethylene oxide units (EO) (wherein m is 12, 25 and 44) [Source: Clariant, Mount Holly, North Carolina].

Test Methods

Particle size

Through-Transmission Electron Microscopy (TEM)

The vesicle composition is analyzed via Cyro-TEM technique according to the following method. Approximately 2.3 μl of sample aqueous solution is placed using a micropipette on a Cu TEM grid coated with a washed and cleaned lacy carbon film with acetone and chloroform. Samples are diluted with 5% solution using deionized water. Excess fluid on the grid surface is removed by absorbing the surface with filter paper for 1.5 seconds to form an aqueous thin film for TEM. The grid is then plunged with liquid ethane in a small vessel located in a larger nitrogen vessel under a -175 ° C atmosphere in a cryo-plunge system to solubilize the water film on the grid and prevent water crystallization. The quenched sample grid is transferred to the cryo-grid box of the cryo-plunge system. The grid box containing the sample is transferred to a Gatan cryo-migration system filled with liquid nitrogen, placed in a cryo-migration system and filled into a cryo-TEM stage cooled to -160 ° C. Samples are charged to TEM (JEOL 2000FX) and the image observed at -160 ° C. A much colder finger, cooled to -180 ° C, is present in the TEM using liquid nitrogen to reduce possible contamination on cold specimen surfaces under high vacuum during TEM analysis. The digital images shown herein are obtained using a peat CCD camera and digital microscopy software attached to the bottom of the TEM column.

Examples 1 to 6 (reference)

The various (AB) n SPEs summarized in Table 1 are prepared via platinum catalyzed hydrosylation of SiH siloxanes with allyl polyethers using the following general method.

SPE manufacturing method

In a 1000 ml three-necked round bottom flask equipped with a temperature probe, electric stirrer and cooler, polyethylene glycol diallyl ether (source: Clariant Corporation, Mount Holly, North Carolina, USA), xylene 61 g and sodium acetate 0.28 in the amounts shown in Table 1. Charge g. The contents of the flask are then heated to 100 ° C. Dimethylhydrogen terminated polydimethyl siloxane is added dropwise via dropping funnels (amounts and structures shown in Table 2). After adding 5 g of siloxane, 0.60 g of platinum catalyst (1,3-diethenyl-1,1,3,3-tetramethyldisiloxane platinum complex in dimethyl siloxane) is added to the mixture. When half of the siloxane is added, an additional 0.69 g of Pt catalyst is added followed by 0.71 g of Pt when all of the siloxane is added. The reaction mixture is mixed for 1 hour to grow the polymer. The xylene solvent is then removed by vacuum stripping at 150 ° C.

In some cases, multiple batches of (AB) n SPE block copolymers are prepared so that the molecular weight of the same (AB) n SPE block copolymer changes from the provided siloxane and polyether formulations. It also demonstrates the suitability of (AB) _n copolymers with different chain lengths (ie n values) in preparing vesicle compositions.

Examples 12-16

(AB) vesicle composition from _n SEP 2

The following methods were used to prepare vesicle compositions summarized as Examples 12 and 13 in Table 3.

Isopropanol (IPA) was added to (AB) _n SPE 2 ((AB) _n block copolymer of M'D ₅₀ M 'siloxane and polyglycol AA1200 polyether with a molecular weight (M _w ) of 50,108 g / mol) and homogeneous To provide a mixture. Water is added slowly with continuous mixing to form a homogeneous dispersion with an average particle size of 0.208 μm. The IPA in the dispersion is then removed using a rotary evaporator under vacuum at ambient temperature to obtain an alcohol-free homogeneous dispersion having an average particle size of 0.223 μm, described as Example 13.

Three additional vesicle compositions are prepared according to the same method as in Example 12 using (AB) n SPE 2 block copolymer, except that any homogenization step is introduced before the vacuum stripping after the mixture has been prepared. Ethanol (EtOH) is used as alcohol instead of IPA. The composition is summarized in Table 3. As the data shows, the homogenization step reduces the average particle size and maintains the homogeneity of the dispersion. Removal of volatile alcohols (EtOH) does not deteriorate the quality of the dispersion.

Particle size distribution diagrams of the compositions of Examples 14-16 are shown in FIG. 1. TEM images between the compositions of Examples 13-16 shown in FIGS. 2-5 demonstrate the presence of vesicle structures.

Examples 17-19

(AB) vesicle composition from _n SPE 1

(AB) _n SPE 1 ((AB) _n block copolymer of M′D ₃₀ M ′ siloxane and polyglycol AA1200 polyether having a molecular weight (M _w ) of 19,486 g / mol) was prepared in Examples 12 and 13 It manufactures according to the method. These vesicle compositions are summarized in Table 4 as Examples 17-19. All three compositions have an average particle size distribution of less than 40 nm (0.040 μm). These examples demonstrate that the removal of alcohol does not affect the quality of the dispersion and the homogenization step is optional.

Examples 20-23

(AB) vesicle composition from _n SPE 3A and B

The vesicle composition was composed of (AB) _n SPE 3A and B (molecular weight (M _w ) of 40,158 g / mol and 44,885 g / mol, respectively) of (AB) _n silicone poly of M'D ₇₅ M 'siloxane and polyglycol AA1200 polyether Ether block copolymers). These dispersions are prepared according to the methods described in Examples 12 and 13 and summarized in Table 5.

Examples 24 and 25

(AB) Alcohol-free vesicle composition from _n SPE 3B

The alcohol-free vesicle composition was prepared by (AB) _n SPE 3B ((AB) _n silicone polyether block copolymer of M'D ₇₅ M 'siloxane and polyglycol AA1200 polyether having a molecular weight (M _w ) of 44,885 g / mol) From alcohol under reduced pressure according to the method described in Examples 12 and 13. The composition is summarized in Table 6.

Examples 26 and 27

(AB) Vitamin A palmitate filled in vesicles from _n SPE 1

Vitamin A palmitate is first mixed with isopropanol in a ratio of 50/50. The vitamin / IPA mixture was then mixed with (AB) _n SPE 1 ((AB) _n block copolymer of M'D ₃₀ M 'siloxane and polyglycol AA1200 polyether, having a molecular weight (M _w ) of 19,486 g / mol). Mix homogeneously. Ethanol is then mixed to form a homogeneous mixture. Deionized water is slowly and gradually incorporated into the SPE / vitamin / alcohol mixture until homogeneous with continuous mixing. The mixture is homogenized using an APV-2000 Gaulin homogenizer to produce a homogeneous dispersion of sub-micron particle size (which is identified as Example 26 in Table 8). The composition of Example 26 is further homogenized. The alcohol is removed under reduced pressure at ambient temperature to yield a composition having an average particle size of 0.54 μm, which is described as Example 27 in Table 8. Removal of alcohol processing aids does not affect dispersion quality and particle size.

Example 28

Vitamin A palmitate filled (AB) n SPE vesicles in the following aqueous dispersions are then prepared according to the methods set forth in the preceding examples of the present invention. (AB) n SPE is a copolymer of 50dp siloxane and polyglycol AA1200 polyether. The final composition of the vesicle dispersion is shown in Table 9.

Vitamin filled SPE vesicles can be easily formulated into skin care formulations. Oil-based vitamins can be easily incorporated into aqueous formulations. The following example provides such an example.

Example 29

Oil in water body lotion

ingredient

Part A

Cetearyl Alcohol: Part 3

Diisopropyl adipate (Crodamol DA): 5 parts

Dimethicone (Dow Corning Silicon 200 / 100cstks): 0.5 part

Potassium Cetyl Phosphate: 1.5 parts

Butylated hydroxytoluene: 0.05 parts

Chelating agent (EDTA): 0.1part

Phenoxyethanol: 0.6 parts

Part B

Water: 100 parts total

Carbomer 980 Thickener: 30 parts

Potassium hydroxide: 1.5 parts

Part C

Vitamin A Palmitate-filled SPE vesicles: 19.88 parts

To prepare a body lotion, the following method is followed. The components of Part A are mixed and homogenized by heating to 85 ° C. After cooling the Part A mixture to 40 ° C., the Part B components are incorporated. The mixture is cooled to ambient temperature. Vitamin A palmitate filled SPE vesicles are incorporated into the mixture and mixed homogeneously. The final mixture is a soft, slightly yellow creamy lotion.

Example 30

Simple Skin Wet Gel

(AB) _n- type SPE vesicles can be easily formulated into aqueous gel formulations. SPE vesicles provide a convenient means of incorporating oil soluble vitamins into a water-rich gel formulation.

ingredient

Part A

Water: volume to be 100% total

Preservative: 0.30%

Polyacrylamide, C13-14 isoparaffin: 1%

Lauret-7 (Sepigel 305): 1%

Part B

Vitamin A Palmitate-filled SPE vesicles: 19.88 parts

In order to prepare a gel, the following method is followed. Mix the components of Part A homogeneously. The vitamin A palmitate filled SPE antifoam dispersion is then incorporated and mixed homogeneously. The final product is a beige soft gel.

To further demonstrate the integrity of the vesicles in the formulation, a cryo-TEM image of the "formulated" product is obtained. A photograph of the gel obtained from the above example is shown in FIG. 6. As shown, vesicles and aggregates of vesicles are well preserved.

(AB) A cryo-TEM image of the “prepared” body lotion illustrated in Example A, prepared from _n SPE vesicles, is shown in FIG. 7. Unique vesicle and aggregate structures are specifically associated with the (AB) n SPE vesicles shown in FIG. 7.

Examples 31 to 32 (reference)

A series of (AB) _n SPEs listed below are prepared according to the methods described in Examples 1-6.

(AB) _n SPE 31A-reaction product prepared from M'D ₁₅ M 'and AA2000, M _w = 16,022

(AB) _n SPE 31B-reaction product prepared from M'D ₁₅ M 'and AA2000, M _w = 24,426

(AB) _n SPE 32A-reaction product prepared from M'D ₁₅ M 'and AA1200, M _w = 33,552

(AB) _n SPE 32B-reaction product prepared from M'D ₁₅ M 'and AA1200, M _w = 35,352

Example 33

(AB) _n SPE 31A water dispersion

(AB) _n SPE 31A (reaction product made from M'D ₁₅ M 'siloxane and polyglycol AA2000 polyether) is a solid waxy material having a melting point of 45-47 ° C. A dispersion of the polymer is prepared by dispersing the solid polymer in water using a low shear mechanical mixing device. The dispersion has an average particle size of 1.867 μm.

Examples 34-36

(AB) _n SPE 31A dispersion in alcohol containing water

(AB) A dispersion of _n SPE 31A copolymer is prepared in an alcohol-water mixture. Solid (AB) _n SPE copolymers are dispersed via a mechanical shearing apparatus into the isopropanol / water mixture at ratios of 5/85 and 20/70, as summarized in Table 10, respectively. In addition, dispersions of sub-micron size in water are also obtained by IPA vacuum stripping of the mixture.

Example 37

Vitamin A Palmitate Filled (AB) _n SPE Particle Dispersion

Vitamin A palmitate is insoluble in water and cannot be dispersed directly in water. This example shows that particle dispersion formation (AB) n SPE block copolymers can be used to incorporate water insoluble vitamins and form stable dispersions in water. The dispersion is prepared as follows: A premix (50/50 weight ratio) of vitamin A palmitate and Dow Corning® DC 1-2287 vinyl silicone fluid is prepared. The premix is incorporated to form a homogeneous mixture with the (AB) _n SPE 31A copolymer. Introduce the mixture slowly into the above mixture while continuing to mix deionized water. As shown in Table 11, dispersions having an average particle size of 1.68 μm are obtained in water. Vitamin A palmitate filled in the dispersion particles is 17%.

Examples 38 to 40

(AB) Si / W emulsion from _n SPE

Three Si / W emulsions of different compositions are prepared via a high shear emulsification process. The process comprises the following steps: Incorporating a silicone fluid into the (AB) _n SPE 32A copolymer to form a homogeneous mixture. A small amount of water is incorporated into the Phase A mixture, followed by high shear mixing using a speed mixer to disperse the water. A small amount of water is added continuously until the mixture is inverted (converted to aqueous continuous emulsion concentrate) or forms a smooth continuous cream. The remaining water is added to dilute the emulsion further to the desired concentration and density. The final emulsion has an average particle size of 1.3 to 2.1 μm.

These Si / W emulsion examples demonstrate that emulsion particles of the desired composition can be prepared comprising (AB) _n SPE polymers and silicone oils. The composition is summarized in Table 12.

Examples 41 and 42

Submerged in water of sub-micron (AB) _n SPE 31B copolymer particles

Another (AB) _n SPE block copolymer is used to prepare Si / W emulsion. (AB) _n SPE 31B is a block copolymer reaction product of M'D ₁₅ M 'siloxane and polyglycol AA2000 polyether (fragment length 44EO units) and has a melting point of 45 to 47 ° C. These Si / W emulsions are prepared by mechanical emulsification using a high shear mixer (speed mixer) similar to that described above. Stepped procedures can be found in the preceding examples. The final Si / W emulsion had average particle sizes of 0.394 μm and 0.725 μm, respectively, as summarized in Table 13.

Examples 43-45

Si / W Latex and Vitamin Filled (Si + O) / W Latex

(AB) _n SPE block copolymers in Si / W emulsion form can be used to transport and protect water-insoluble oils and materials. These emulsions can then be incorporated into the aqueous final product and formulation.

Vitamin A palmitate is water insoluble and cannot be incorporated directly into aqueous formulations. These examples show that stable Si / W emulsions containing varying amounts of vitamin A palmitate have been successfully prepared from (AB) _n SPE block copolymers.

Si / W emulsions are prepared using an SPE 32A copolymer, which is the (AB) _n block copolymer product of M'D ₁₅ M 'siloxane and polyglycol AA1200 polyether with a melting point of 27 to 32 ° C. The following Si / W and (Si + O) / W emulsions are prepared using a DC 245 silicon cyclic material and a DC 1-2287 vinyl silicone fluid.

These emulsions are prepared according to the following method: Vitamin A palmitate is first mixed with DC 1-2287 vinyl silicone fluid to form a homogeneous mixture, and then mixed into (AB) _n SPE 32A copolymer with mixing to premix the premix. Get Deionized water is gradually gradually incorporated into the Phase A mixture using a high shear mixer (speed mixer) until the mixture is converted to a water continuous phase mixture. The remaining water is added under shear to dilute to the desired composition. The final latex is a soft milky latex as summarized in Table 14.

Two vitamin A palmitate filled (AB) _n SPE block copolymer emulsions have particle sizes of 1.62 μm and 1.02 μm, respectively. Vitamin loads are 13.4% and 20.3%, respectively.

Examples 46 and 47

Vitamin-Filled Latex Formulated as Skin Care Products

Aqueous dispersions of vitamin A palmitate filled (AB) _n SPE particles are prepared according to the methods set forth in the preceding examples. Example 46 was prepared from 15dp siloxane and polyglycol AA2000 polyether of (AB) _n SPE air dispersion of the copolymer prepared from Example 47 and 15dp are siloxane and polyglycol AA1200 polyether (AB) _n SPE copolymer. The final compositions of these dispersions are listed in Table 15.

Vitamin filled SPE particle dispersions are formulated into skin care formulations.

Oil in water body lotion

ingredient

Part A

Cetearyl Alcohol: Part 3

Diisopropyl adipate (Crodamol DA): 5 parts

Dimethicone (Dow Corning Silicon 200 / 100cs): 0.5 part

Potassium Cetyl Phosphate: 1.5 parts

Butylated hydroxytoluene: 0.05 parts

Chelating agent (EDTA): 0.1part

Phenoxyethanol: 0.6 parts

Part B

Water: 100 parts total

Carbomer 980 Thickener: 30 parts

Potassium hydroxide: 1.5 parts

Part C

Vitamin A Palmitate Filled SPE Particle Dispersion: 19.88 parts

To prepare the body lotion, the following method is followed: The components of Part A are mixed and homogenized by heating to 85 ° C. After cooling the Part A mixture to 40 ° C., the Part B components are incorporated. The mixture is cooled to ambient temperature. Vitamin A palmitate filled SPE particle dispersions are incorporated into the mixture and mixed homogeneously. The final mixture is a slightly yellow soft creamy lotion.

The cryo-TEM image of the "manufactured" body lotion described in this example confirms that the dispersed particles are viscous and stable after preparation of the formulation.

Moisture Gel for Skin

(AB) _n- type SPE particle dispersions may be formulated into aqueous gel formulations. SPE vesicles provide a convenient means of incorporating oil soluble vitamins into water rich gel formulations.

ingredient

Part A

Water: volume to be 100% total

Preservative: 0.30%

Polyacrylamide, C13-14 Isoparaffin, Lauret-7 (Sepigel 305): 1%

Part B

Vitamin A Palmitate Filled SPE Particle Dispersion: 19.88 parts

To prepare the gel, follow the procedure below: Mix the components of Part A homogeneously. The vitamin A palmitate filled SPE particle dispersion is then incorporated and mixed homogeneously. The final product is a beige soft gel.

To further demonstrate the integrity of the dispersion particles in the formulation, a cryo-TEM image of the "formulated" product is obtained. The image of the gel prepared from this example confirms that the dispersion particles are well preserved.

Examples 48-49

A water dispersion of the following vitamin A palmitate filled (AB) _n SPE particles is prepared according to the method set forth in the preceding examples of the invention. The emulsion shown in Example 48 is prepared from a copolymer of (AB) _n SPE 32A, i.e. 15dp siloxane and polyglycol AA2000 polyether, and the emulsion shown in Example 49 is (AB) _n SPE 31B, i.e. 15dp siloxane and polyglycol Prepared from a copolymer of AA2000 polyether. The final compositions of these dispersions are shown in the following table. In this case, no water miscible solvent is necessary. DC 1-2287, ie methylvinylsilicone cyclic compound (Source: Dow Corning Corporation), is used. The composition of these two emulsions is shown in Table 16 below.

(AB) The stability of the emulsions prepared from _n SPE copolymers is also described. After five weeks of aging at 40 ° C., the particle sizes of these emulsions were found to be nearly identical to the initial values as shown in Table 16.

Claims (21)

An aqueous composition with dispersed particles, wherein the dispersed particles are (AB) _n block silicon polyether aerials of the formula-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z-. Including coalesce wherein x and y are greater than 4, m is 2 to 4, z is greater than 2, R is independently a monovalent organic group, and R ¹ is a divalent hydrocarbon having 2 to 30 carbon atoms Aqueous composition. The aqueous composition of claim 1, wherein the (AB) _n- block silicone polyether copolymer has an average value of m of 2, R is methyl, R ¹ is propylene, and a weight average molecular weight is 1,500 to 150,000. The aqueous composition of claim 1 or 2, wherein the dispersed particles have an average particle size of less than 10 μm. The aqueous composition of claim 3 wherein the value of x / (x + y) is 0.2 to 0.9. The aqueous composition of claim 3 wherein the dispersed particles are vesicles. The aqueous composition of claim 3 wherein x is from 20 to 100. The aqueous composition of claim 3 wherein the composition is an emulsion. The aqueous composition of claim 3 wherein x is from 5 to 19. 5. The aqueous composition of claim 3 further comprising a water miscible volatile solvent. The aqueous composition of claim 3 further comprising volatile methyl siloxane. (AB) _n block silicone polyether copolymer (A) of formula-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z- , wherein x and y are Greater than 4, m is 2 to 4, z is greater than 2, R is independently a monovalent organic group, R ¹ is a divalent hydrocarbon of 2 to 30 carbon atoms and any water miscible volatile solvent (B ) Is combined with water to form an aqueous dispersion (I), Mixing the aqueous dispersion to form dispersed particles of the (AB) _n silicone polyether copolymer having an average particle size of 10 μm (II) and Optionally removing the water miscible volatile solvent from the water dispersion (III). The method of claim 11, wherein the dispersed particles are vesicles. A vesicle composition prepared by the method of claim 11. 14. The vesicle composition of claim 13, further comprising an active ingredient for personal care, home care or health care. (AB) _n block silicone polyether copolymer (A) of formula-[R ¹ (R ₂ SiO) _x (R ₂ SiR ¹ O) (C _m H _2m O) _y ] _z- , wherein x and y are Greater than 4, m is 2 to 4, z is greater than 2, R is independently a monovalent organic group, R ¹ is a divalent hydrocarbon having 2 to 30 carbon atoms) and a water miscible volatile solvent (B) Mixing to form a hydrophobic phase (I) and A process for producing a water continuous phase emulsion having an average particle size of less than 10 μm, comprising the step (II) of adding water to the hydrophobic phase to form a water continuous phase emulsion. The process of claim 15 wherein the average particle size is less than 10 μm, comprising silicone or organic oils upon mixing of step (I). The process of claim 15, wherein the silicone is a volatile methyl siloxane with an average particle size of less than 10 μm. The process for producing a water continuous phase emulsion according to claim 15, wherein the silicone is a vinyl functional organopolysiloxane with an average particle size of less than 10 μm. 19. The aqueous continuous phase emulsion according to any one of claims 15 to 18, further comprising an active ingredient for personal care, home care or health care in step (I). Manufacturing method. The product prepared by any one of claims 15-19. A personal care, home care and health care composition comprising the composition of claim 20.

Images