KR20060094876A - Functional health foods comprising coenzyme q10 for alleviating alcohol intoxication after drinking - Google Patents

Abstract

The present invention relates to a dietary supplement for eliminating and alleviating alcoholic disorders containing coenzyme Q10 as an active ingredient, and more particularly, to coenzyme Q10 for removing active oxygen, which is thought to be the cause of hangover, as an active ingredient. Health functional foods to remove and alleviate alcoholic disorders, including hangover or flushing, and to take the same before, during and after drinking, after drinking or the day after drinking, to cure the alcoholic disorder, and to remove and alleviate the alcoholic disorder. The present invention relates to a health functional food that can be used as a snack to which the pharmaceutical composition is added, and when used, it can effectively reduce social side effects such as drinking.

Hangover, drinking, coenzyme Q10, free radicals, antioxidants

Description

Functional health foods comprising coenzyme Q10 for alleviating alcohol intoxication after drinking}

Figures 1a and 1b shows the degree of inhibition of the production of lipid peroxide by coenzyme Q10 administration of the present invention.

2 Shows the change in the production of prostaglandin E ₂ in the blood upon alcohol administration.

Figure 3 shows the change in the production of prostaglandin E ₂ in the blood upon coenzyme Q10 and alcohol administration of the present invention.

4A and 4B Is a picture showing the flushing inhibitory effect by taking coenzyme Q10 of the present invention when drinking.

5a and 5b is another picture showing the effect of suppressing flushing by taking coenzyme Q10 of the present invention when drinking.

The present invention relates to a dietary supplement for eliminating and alleviating alcoholic disorders containing coenzyme Q10 as an active ingredient.

Until now, the development of substances for eliminating or alleviating alcoholic disorders has been mainly used to find substances that reduce the concentration of alcohol and acetaldehyde in the blood. But the reason is that the mechanism of hangover is not yet known.

Acetaldehyde, a major metabolite of alcohol, is a highly reactive toxic substance and is known to be the most potent agent of hangover because it directly affects the nervous system and causes various side effects (Sherif, S., Wahlstrom, G., Oreland, L. Alcohol.Clin.Exp.Res. 17 (6): 1313-1318, 1993). However, a hangover can occur up to 20 hours after drinking alcohol with almost no concentration of alcohol or acetaldehyde in the blood. In addition, when drinking alcohol, disulfiram (an aldehyde dehydrogenase inhibitor used in the treatment of alcoholic patients, which concentrates acetaldehyde in the body to induce a strong discomfort) does not significantly increase symptoms such as flushing and vomiting caused by drinking alcohol. However, these are not all symptoms of a hangover. In other words, hangovers are not simply caused by acetaldehyde. Nevertheless, acetaldehyde has been recognized as a major cause of hangovers, and so far the focus has been on finding substances that induce rapid breakdown of alcohol and acetaldehyde in the body in relation to drinking alcohol.

In alcohol metabolism, other toxic substances are produced besides acetaldehyde, which are highly reactive oxygen compounds, also called "active oxygen." The free radicals appear after drinking, whereby arachidonic acid is released from the cells, and cyclooxygenase-2 (hereinafter referred to as "COX-2"), an enzyme that synthesizes prostaglandin (hereinafter abbreviated as "PG"). Is also induced, resulting in a strong hangover even when acetaldehyde is absent in the body because prostaglandin E ₂ (PGE ₂ ) is synthesized which causes pain.

"Hangover" can collectively cause a number of symptoms, the most common of which are dizziness, headache, stomachache (heartache), and other tiredness, irritability, nausea, diarrhea, thirst, sleep disorders, and chills. (Cephalagia, 3 (1), 31-36 (1983)). Also, flushing or vomiting can occur when you drink or shortly after drinking alcohol. In particular, flushing was confirmed to be caused by free radicals according to the present invention.

Coenzyme Q10 is called ubiquinone and is a powerful antioxidant enzyme called coenzyme Q that helps the enzyme work. In addition, it is a benzoquinone derivative having a CH ₃ O group at the 2,3-position, which is commonly distributed in the biological system, and is contained in a large amount in the intracellular mitochondria. Its action is to receive and transfer electrons to cytochrome b in the flavinase and bihemite.

The present inventors confirmed that cyclooxygenase (COX-2) is induced by active oxygen generated by decomposition of alcohol and acetaldehyde, which causes metabolic hangover with PGE ₂ . In addition, a lot of heat is generated when alcohol is decomposed, and at this time, mitochondria and cellulosic tissues produce a lot of free radicals. Indicative coenzyme Q10 was determined to be excellent in removing the hangover.

Accordingly, the present inventors have continued to develop a method for treating alcoholic disorders caused by drinking, and as a result, coenzyme Q10 which removes free radicals to induce the production of PGE ₂ known as the cause of hangover, Pharmaceutical compositions further containing other antioxidants, acetaldehyde-lowering agents, COX-2 inhibitors, etc. eliminate or alleviate alcoholic disorders, including hangovers and flushing, particularly effective amounts of coenzyme Q10 in the range of 10 mg to 20 g The present invention was successfully completed by confirming that the method of pre-drinking, mid-drinking, post-drinking or the next day of drinking is more effective in treating the alcoholic disorder.

An object of the present invention is to provide a dietary supplement for eliminating and alleviating alcoholic disorders containing coenzyme Q10 as an active ingredient.

In order to achieve the above object, the present invention provides a pharmaceutical composition for the removal and alleviation of alcoholic disorders containing coenzyme Q10 (coenzyme Q10) as an active ingredient.

In addition, the present invention is a pharmaceutical for the removal and alleviation of alcoholic disorders in addition to the coenzyme Q10 to add one or more selected from the group consisting of squalene, vitamin E, peptides, gourmet, hawthorn extract, alder extract, brown root extract To provide a composition.

The present invention also includes coenzyme Q10 in an effective amount in the range of 10 mg to 20 g, preferably in an effective amount in the range of 50 mg to 1 g, to eliminate alcoholic disorders taken before drinking, during drinking, after drinking or the day after drinking. And health functional foods for emollients.

In addition, the present invention provides a health functional food containing coenzyme Q10 in an effective amount in the range of 10 mg to 20 g and may be used as a preferred snack before taking, before drinking, during drinking, or after drinking.

In addition, the present invention provides a health functional food that can be used as a snack to add the pharmaceutical composition for eliminating and alleviating the alcoholic disorder.

Hereinafter, the present invention will be described in detail.

Although acetaldehyde is considered to be a representative cause of alcoholic disorders including hangover, the exact mechanism is not yet known. Thus, in the search for a hangover removing substance, a method of lowering the alcohol concentration and acetaldehyde concentration in blood has been sought.

However, hangovers occur mainly after the decomposition of acetaldehyde, which produces a large amount of prostaglandin E ₂ , known as pain material. From these physiological phenomena, free radicals in alcohol metabolism can induce prostaglandin E ₂ , so these free radicals are considered to be the main cause of hangover.

In addition, the addition of alcohol or acetaldehyde to the cell produces lipid peroxide, because free radicals are generated as the alcohol and acetaldehyde are broken down (Olin, KL, Cherr, GN, Rifkin, E., Keen, CL). Toxicology, 17: 110 (1-3); 1-8, 1996). In this way, free radicals induce lipid peroxidation, as well as cyclooxygenase (COX-2), which converts arikidonic acid to prostaglandin E ₂ (PGE ₂ ), and this increase in PGE ₂ causes hangover pain. .

The present invention provides the use of coenzyme Q10 (coenzyme Q10) as a hangover removal material according to the hangover mechanism described above.

Specifically, the present invention provides a dietary supplement for eliminating and alleviating alcoholic disorders comprising coenzyme Q10 as an active ingredient.

The present invention provides a dietary supplement for the elimination and alleviation of alcoholic disorders further comprising other antioxidants in addition to the coemzyme Q10. As the other antioxidants, it is preferable to use squalene, vitamin E and peptides alone or in combination. In addition to the above antioxidants, it is more preferable to add substances known to be effective in hangover as a lowering agent of acetaldehyde concentration in the body, namely, gourmet, hollyhock extract, alder extract, and root extract, alone or in combination.

The functional food for elimination and alleviation of alcoholic disorders of the present invention comprises coenzyme Q10 in an effective amount in the range of 10 mg to 20 g, preferably in an effective amount in the range of 50 mg to 1 g, before drinking, during drinking, after drinking or It is desirable to take the next day after drinking.

The present invention also provides the use of coenzyme Q10 for the removal of free radicals before and after drinking.

The present invention also provides a method of eliminating or alleviating alcoholic disorders by taking the coenzyme Q10.

In this case, in addition to the coenzyme Q10, it is preferable to take another antioxidant, and more preferably, to take squalene, vitamin E, and peptides alone or in combination as an antioxidant. In addition to the coenzyme Q10 and the antioxidant, it is also preferable to take a substance known to have an effect on hangover as a lowering agent of acetaldehyde in the body, namely, gourmet, hollyhock extract, alder extract, and root extract. Do.

Further, in addition to the coenzyme Q10, antioxidants, inhibitors of acetaldehyde concentration in the body, and inhibitors of COX-2 induced by free radicals, taking additional complexes such as chitosan, vitamin B1, vitamin B2 and vitamin C desirable.

In addition, the method of eliminating or alleviating the alcoholic disorder of the present invention is a form of health functional food containing coenzyme Q10 in an effective amount in the range of 10 mg to 20 g, which is to be taken before drinking, during drinking, after drinking or the day after drinking. desirable.

In addition, the present invention provides a use of the pharmaceutical composition for eliminating and alleviating the alcoholic disorder to add to the health functional food that can be used as a snack.

Health functional foods for eliminating and alleviating alcoholic disorders of the present invention may include health foods for health, health drinks, food additives and animal feed additives, and all forms such as powders, granules, tablets, capsules or beverages. It is possible.

Coenzyme Q10 of the present invention may be added to food or beverage for the purpose of eliminating and alleviating alcoholic disorders, wherein coenzyme Q10 added in food or beverage is typically 0.1 to 15% by weight of the total food weight, preferably It may be added at 1 to 10% by weight.

Hereinafter, the present invention will be described in more detail with reference to Examples.

However, the following examples are merely to illustrate the invention, but the content of the present invention is not limited to the following examples.

Example  1. Coenzyme Q10  Measurement of Lipid Peroxide in the Body After Administration

In order to investigate the effect of coenzyme Q10 on the inhibition of free radicals, rats (450 g body weight) were divided into two groups of 10 animals each, only 3 ml of 50% ethanol in one group and 3 ml of 50% ethanol in the other group. And 0.08 g of coenzyme Q10 was dissolved and administered together. Thereafter, blood was collected at time intervals, and lipid peroxides were quantified by a thiobarbuturic acid method (Yagi, K. Biochem. Med. 15: 212-216, 1976). Blood alcohol concentrations were measured by headspace gas chromatography analysis ( J. Anal. Toxicol., 4 (1): 43-45. 1980).

The measurement results are shown in FIGS. 1A and 1B. In Figure 1a □ when ethanol only administration, ○ is a measure of the concentration of lipid peroxide (LPO) in the blood when coenzyme Q10 is administered together, □ in Figure 1b □ is coenzyme Q10 when only ethanol is administered In the case of administration together, blood alcohol concentration was measured. As shown in Figures 1a and 1b when coenzyme Q10 was administered together, the rate of alcohol degradation was faster than the administration of alcohol alone, the generation of lipid peroxide was also much lower. Therefore, coenzyme Q10 with alcohol was found to be very effective for the removal of free radicals in the body.

Example 2. Prostaglandin E at Coenzyme Q10 Administration ₂ Investigation of changes

In the present invention, in order to observe changes in prostaglandin (PGE ₂ ) in the blood after alcohol intake, 300 g rats were fasted for 12 hours and 3 g / kg of alcohol was orally administered. Thereafter, blood was collected from the tail vein over time, and the amount of PGE ₂ in the blood was quantified using a commercially available PGE ₂ measurement kit. Alcohol and acetaldehyde concentration in the blood was measured according to the procedure of Example 1, the measurement results are shown in FIG.

2 is the concentration of prostaglandin E ₂ (PGE), △ is the alcohol concentration in the blood, □ is the acetaldehyde concentration (blood acetaldehyde concentration) in the blood. As shown in FIG. 2, PGE ₂ started to increase immediately after ingesting alcohol and maintained high production even after 8 hours when no alcohol was detected in the blood. Therefore, people could find out why hangover symptoms remain until 20 hours after alcohol consumption.

Coenzyme Q10 was also administered in an amount of 1 g / kg, one third of which was administered 1 hour before alcohol administration, and the other was dissolved in alcohol. 3 shows the result of the measurement. According to FIG. 3, since PGE ₂ has a very low value, the production of PGE ₂ is significantly suppressed by coenzyme Q10. In addition, it can be seen that the alcohol and acetaldehyde concentration slightly lower than that shown in Figure 2, these concentrations were found to drop quickly when taking coenzyme Q10.

Example  3. Coenzyme Q10 Inhibition effect of hangover symptom by

In order to observe the change in the hangover symptoms caused by coenzyme Q10, the subjects of 16 university students who had a hangover every time when they consumed Korean soju, soju, 5 times or more (alcohol content 80-120 ml) for 2 months An experiment on hangover symptoms was conducted. Suffering from hangover, approximately 1 bottle ± 0.5 bottles were taken and 1 g of coenzyme Q10 was divided into 30 minutes of alcohol intake for 2 hours. The following day, the survey was conducted with a severe hangover of 10 and a hangover of 0. At this time, placebo non-administered group was to take the flour mixed with beta-carotene 1%.

Table 1 shows the measurement results. Headache, stomach pain, nausea, and dizziness were rarely seen in the coenzyme Q10 group, which was statistically significant. In addition, facial flushing and burning were observed immediately after drinking. As shown in Table 1, it was significantly suppressed, and all of them were statistically significant. In addition, tiredness, irritability, diarrhea, thirsty, sleep disorders, chills, etc. showed an excellent effect. In these experiments, coenzyme Q10 was rarely seen in all alcoholic disorders, which was attributed to its superior free radical scavenging ability.

Hangover removal effect by coenzyme Q10 administration   division   Control  Coenzyme Q10 Headache 8.5 0.5 ^* Stomach pain 7.7 0.5 ^* Flushing 7.9 2.0 ^* Heat in face 8.5 2.0 ^* Nausea 7.5 0.5 ^* Malaise 8.3 0.6 ^* Dizziness 9.0 0.6 ^*

* P <0.05 compared to baseline

Example  4. Coemzyme Q10 Of Hangover Elimination Effect with Different Dose Times

In order to investigate the hangover elimination effect according to the administration time of coenzyme Q10, even if you drink 1/2 bottle (180 ml) of soju (alcohol concentration), the two persons who feel hangover are divided into groups 1 and 2, Two people who felt drowsiness (drinks) after drinking one bottle (360 ml) were divided into Group 1 and Group 2, respectively. Next, coenzyme Q10 (500 mg) was administered before, during, after drinking, and the day after drinking. These experiments were carried out at intervals of two weeks, the placebo and the questionnaire method was performed as described in Example 3, but in the case of a hangover, the questionnaire was obtained by answering the overall degree, rather than making each of them as detailed in Table 1. The results are shown in Table 2.

As shown in Table 2, coenzyme Q10 was rarely hanged the next day when taken before, during, or after drinking.However, when taking the hangover the next day, nausea, fatigue, etc., were taken about 30 minutes after taking it. More than 40% disappeared, but only about 40% were effective in removing headaches. Therefore, coenzyme Q10 is effective to take when drinking, and it is confirmed that taking a hangover can significantly alleviate the hangover.

Hangover removal effect of coenzyme Q10 Dosing time Hangover degree Not coenzyme Q10 8 Administration before drinking One Dosing while drinking One Immediately after drinking One Hangover 3

Example  5. Coenzyme Q10 Of Hangover Elimination Effect with Different Dose Concentrations

In order to investigate the hangover removal effect according to the concentration of coenzyme Q10, two people of four persons who can hardly drink alcohol such as flushing on the face even after drinking 1 glass (45 ml) of alcohol with 22% alcohol Divided by. Coenzyme Q10 was administered to them in an amount of 5 mg, 10 mg, 20 mg, 50 mg, 100 mg, 1 g and 20 g, and the degree of appearance of hangover was observed. Specifically, in one experiment, coenzyme Q10 was added without addition of 5 mg, two weeks later with 10 mg, 20 mg of coenzyme Q10, 50 mg, 100 mg of coenzyme Q10 after two weeks, and then two weeks later. Then, the experiment was conducted by administering 1 g, 20 g of coenzyme Q10. Placebo and questionnaire methods were carried out as described in Examples 3 and 4, but the total dose was kept constant by adjusting the amount of flour added.

As shown in Table 3, coenzyme Q10 was found to relieve the symptoms of hangover at 10 mg or more administration, especially face flushing and vomiting was confirmed that much. It can be said that there is no upper limit of the concentration, 20 g to remove most of the hangover, preferably in the range of 50 mg to 1 g was suitable.

Hangover removal effect according to the concentration of coenzyme Q10 Addition amount Hangover degree Coenzyme Q10 no addition 8 5 mg 8 10 mg 6 20 mg 6 100 mg 4 1 g 0.5 2 g 0 20 g 0

Example  6. Coemzyme Q10 Investigation of the Hangover Removal Effect by the Mixed Addition of Sodium and Other Additives

In order to investigate the effect of the mixed addition of the other additives on the hangover removal, 10 people who are weak in alcohol to drink 1/2 bottle of soju and each additive for 2 hours, experiment in the same process as in Example 4 Was carried out. The coenzyme Q10 is 200 mg, 1 g squalene, 1000 IU vitamin E, 2 g silk peptide, 2 g of gourmet low molecular weight enrichment, 3 g Gurume, 500 mg aspirin, 500 mg Tylenol, holly, Alder and brown root were taken 5 g each. The placebo group had a mixture of jasmine tea and caramel to make it darker.

Table 4 shows the results. As shown in Table 4, the mixed addition showed little dizziness, headache, stomach pain (heartburn), and tiredness corresponding to a hangover, and there was almost no flushing or nausea appearing after or after drinking. Antioxidants and acetaldehyde-lowering agents were also effective for flushing and nausea. Aspirin and tylenol were weak at suppressing these symptoms, but they were very good at removing the hangover the next day. Of course, these were also effective in combination administration, chitosan, vitamin B, C complex (vitamin B1 16 mg, vitamin B2 10 mg, vitamin C 300 mg) administration was also good.

Hangover removal effect by co-zyme Q10 and other additives division Hangover degree Coenzyme Q10 3 Squalene 0 Vitamin E 1.0 Soybean Peptides 0.5 Gourmet 0 aspirin 0 Tylenol 0 Hut 0.5 Alder 0.5 Rooting 0.5

Example  7. In the form of snacks Coemzyme Q10 Investigation of hangover removal

In the present invention, to investigate the effect of coenzyme Q10 contained in the food in the form of snacks to hangover removal, coenzyme Q10 is made into capsules (capsule) while mixing with a light snack while experimenting in the same process as in Example 4 Hangover experiment was done. The placebo non-administered group was administered in the same manner by encapsulating wheat flour mixed with 1% beta-carotene. As a result, the same results as shown in Table 2 were obtained. Therefore, the alcoholic disorders were removed or alleviated even if they were made with snacks.

Example  8. Investigate the effects of alcohol flushing when taken before drinking

In order to investigate the flushing effect of coenzyme Q10, two people whose face is always flushed with a glass of soju (alcohol concentration 22 degrees) (50 ml) were selected. They were asked to drink soda at 108 mL, 72 mL after 30 minutes, 90 mL after 45 minutes, and 90 mL after 1 hour. During this time, about 15 minutes after the initial drinking, redness began to appear on the face. The results are shown in Figures 4a and 5a. Each photograph was taken two hours before and after drinking, both of which showed severe redness on the face.

In addition, coenzyme Q10 (Co-Q _10, which is commercially available when drinking in the same manner after a week) Total intake: 600 mg). How to eat 200 mg 1 hour before drinking, 30 minutes before drinking 200 mg intake, 100 mg initial drink, 30 minutes after drinking 100 mg was taken. In the same way as the first experiment, soju was allowed to drink 108 ml, 72 ml after 30 minutes, 90 ml after 45 minutes, and 90 ml after 1 hour. And face change was observed for 3 hours. Coenzyme Q10 did not cause redness on the face for 3 hours. However, alcohol is said to heat the face. The photographs of FIGS. 4B and 5B were taken 1 hour after drinking, indicating that flushing did not occur before and after drinking coenzyme Q10.

The suppression of flushing by coenzyme Q10 was observed when flushing appeared after drinking, but even after taking 30 minutes or more after flushing, flushing disappeared or was less than half (1/2) compared with not taking. This, of course, was greatly influenced by the amount of alcohol consumed and the dose of coenzyme Q10.

Example 9 Investigation of Flush Mitigation Effects During and After Drinking

In the present invention, in order to investigate the flushing effect of coenzyme Q10, 180 ml of soju (alcohol concentration 22 degrees) was given to 4 people with flushing on the face when drinking all over the face. Both men were given 500 mg of coenzyme Q10. After about 30 minutes, the flushing weakened and most of the flushing disappeared an hour later. But those who did not take coenzyme Q10 remained flushed.

As described above, the present invention can significantly remove the hangover by taking coenzyme Q10 before drinking, during drinking, after drinking or the next day to remove or alleviate hangovers. You can greatly reduce the social side effects of this year.

Claims (5)

Health functional food for eliminating and alleviating alcoholic disorders containing coenzyme Q10 as an active ingredient. The method of claim 1, Health functional food for the removal and alleviation of alcoholic disorders, characterized in that the addition of one or more selected from the group consisting of squalene, vitamin E, peptides, gourmet, hut extract, alder extract, root extract. The method according to claim 1 or 2, A dietary supplement for the removal and alleviation of alcoholic disorders, characterized by taking coenzyme Q10 in an effective amount ranging from 10 mg to 20 g before, during, or after drinking. A dietary supplement that can be used as a snack in which a pharmaceutical composition for eliminating and alleviating alcoholic disorders containing coenzyme Q10 as an active ingredient is added. The method of claim 4, wherein A dietary supplement comprising coenzyme Q10 in an effective amount ranging from 10 mg to 20 g before, during, or after drinking.

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