KR20060013428A - 항-염증 치료제로서 안티센스 올리고뉴클레오타이드 및에스아이알엔에이로의 아폽토시스-특이적이아이에프-5에이(＂이아이에프-5에이1＂)의 저해 - Google Patents

항-염증 치료제로서 안티센스 올리고뉴클레오타이드 및에스아이알엔에이로의 아폽토시스-특이적이아이에프-5에이(＂이아이에프-5에이1＂)의 저해 Download PDF

Info

Publication number
KR20060013428A
KR20060013428A KR1020057023388A KR20057023388A KR20060013428A KR 20060013428 A KR20060013428 A KR 20060013428A KR 1020057023388 A KR1020057023388 A KR 1020057023388A KR 20057023388 A KR20057023388 A KR 20057023388A KR 20060013428 A KR20060013428 A KR 20060013428A
Authority
KR
South Korea
Prior art keywords
apoptosis
cells
cell
specific eif
expression
Prior art date
Application number
KR1020057023388A
Other languages
English (en)
Korean (ko)
Inventor
죤 이 톰슨
캐서린 테일러
Original Assignee
세네스코 테크놀로지스 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 세네스코 테크놀로지스 인코포레이티드 filed Critical 세네스코 테크놀로지스 인코포레이티드
Publication of KR20060013428A publication Critical patent/KR20060013428A/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020057023388A 2003-06-06 2004-06-07 항-염증 치료제로서 안티센스 올리고뉴클레오타이드 및에스아이알엔에이로의 아폽토시스-특이적이아이에프-5에이(＂이아이에프-5에이1＂)의 저해 KR20060013428A (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US47619403P 2003-06-06 2003-06-06
US60/476,194 2003-06-06
US50473103P 2003-09-22 2003-09-22
US60/504,731 2003-09-22
US52824903P 2003-12-10 2003-12-10
US60/528,249 2003-12-10
US55767104P 2004-03-31 2004-03-31
US60/557,671 2004-03-31
US57581404P 2004-06-02 2004-06-02
US60/575,814 2004-06-02

Publications (1)

Publication Number Publication Date
KR20060013428A true KR20060013428A (ko) 2006-02-09

Family

ID=34084831

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057023388A KR20060013428A (ko) 2003-06-06 2004-06-07 항-염증 치료제로서 안티센스 올리고뉴클레오타이드 및에스아이알엔에이로의 아폽토시스-특이적이아이에프-5에이(＂이아이에프-5에이1＂)의 저해

Country Status (9)

Country Link
EP (1) EP1636364A2 (fr)
JP (1) JP5666074B2 (fr)
KR (1) KR20060013428A (fr)
AU (1) AU2004258070B2 (fr)
CA (1) CA2528372A1 (fr)
IL (1) IL172365A0 (fr)
NZ (2) NZ574973A (fr)
TW (1) TW200512293A (fr)
WO (1) WO2005007853A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381708B2 (en) 2001-07-23 2008-06-03 Sensco Technologies, Inc. Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
NZ542665A (en) 2003-03-05 2008-05-30 Senesco Technologies Inc Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
GB0312148D0 (en) 2003-05-28 2003-07-02 Aventis Pharma Ltd Stabilized pharmaceutical products
US20140371299A1 (en) * 2004-06-07 2014-12-18 Senesco Technologies, Inc. Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis
EP1769075A2 (fr) * 2004-07-20 2007-04-04 Senesco Technologies, Inc. Utilisation d'arnsi eif-5a specifiques de l'apoptose et de polynucleotides antisens pour inhiber/supprimer une reponse inflammatoire
AR051786A1 (es) * 2004-12-03 2007-02-07 Senesco Technologies Inc Eif-5a especifico de la apoptosis y polinucleotidos que codifican el mismo
WO2007070824A2 (fr) * 2005-12-13 2007-06-21 Senesco Technologies, Inc. Utilisation d'eif-5a pour detruire les cellules d'un myelome multiple
AU2007226878A1 (en) * 2006-03-20 2007-09-27 Senesco Technologies, Inc. A novel method of protecting islet cells from apoptosis during the donor harvesting process
WO2007109674A2 (fr) * 2006-03-20 2007-09-27 Senesco Technologies, Inc. Utilisation d'arnsi eif-5a spécifique de l'apoptose pour la régulation négative de l'expression de cytokines pro-inflammatoires afin de traiter la septicémie
NZ596310A (en) * 2006-03-20 2013-05-31 Senesco Technologies Inc A novel method of protecting islet cells from apoptosis during the donor harvesting process
WO2007115047A2 (fr) * 2006-03-29 2007-10-11 Senesco Technologies, Inc. INHIBITION DE LA RÉPLICATION DU VIH ET DE L'EXPRESSION DE p24 PAR LE BIAIS D'elF-5
EP2195429A2 (fr) * 2007-08-20 2010-06-16 Senesco Technologies, Inc. Utilisation de l'arnsi eif-5a1 pour protéger des îlots de langerhans de l'apoptose et pour conserver leur fonctionnalité
CN102282259A (zh) 2008-03-07 2011-12-14 森尼斯科技术公司 与有义构建体实现期望多核苷酸的表达的用途相组合的、sirna实现内源基因的减量调节的用途
JP5578522B2 (ja) 2008-05-27 2014-08-27 義規 世古 アポトーシス誘導薬
US8445638B2 (en) 2008-09-03 2013-05-21 Senesco Technologies, Inc. Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK109997A3 (en) * 1995-02-13 1998-04-08 Ciba Geigy Ag Eukaryotic initiation factor 5a (eif-5a) mutants
WO2002096927A2 (fr) * 2001-05-29 2002-12-05 Ribozyme Pharmaceuticals, Incorporated Modulation a base de l'acide nucleique des maladies et troubles de l'appareil reproducteur chez la femme
US7381708B2 (en) * 2001-07-23 2008-06-03 Sensco Technologies, Inc. Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
US7968523B2 (en) * 2001-07-23 2011-06-28 Senesco Technologies, Inc. Method for inducing apoptosis using apoptosis-specific EIF5-A
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
ATE556720T1 (de) * 2001-07-23 2012-05-15 Univ Leland Stanford Junior Verfahren und zusammensetzungen zur rnai vermittelten inhibierung der genexpression in säugetieren
NZ542665A (en) * 2003-03-05 2008-05-30 Senesco Technologies Inc Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1

Also Published As

Publication number Publication date
IL172365A0 (en) 2006-04-10
AU2004258070A1 (en) 2005-01-27
NZ574973A (en) 2010-10-29
NZ544159A (en) 2009-04-30
TW200512293A (en) 2005-04-01
JP2006526989A (ja) 2006-11-30
JP5666074B2 (ja) 2015-02-12
EP1636364A2 (fr) 2006-03-22
WO2005007853A3 (fr) 2005-10-27
AU2004258070B2 (en) 2008-12-11
WO2005007853A2 (fr) 2005-01-27
CA2528372A1 (fr) 2005-01-27

Similar Documents

Publication Publication Date Title
US8754057B2 (en) Inhibition of apoptosis-specific eIF-5A(eIF-5A1″) with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics
KR20060013428A (ko) 항-염증 치료제로서 안티센스 올리고뉴클레오타이드 및에스아이알엔에이로의 아폽토시스-특이적이아이에프-5에이(＂이아이에프-5에이1＂)의 저해
KR20070077225A (ko) 아폽토시스-특이적 ｅＩＦ-5Ａ 및 이를 암호화하는폴리뉴클레오타이드
US20060287265A1 (en) Apoptosis-specific eIF-5A and polynucleotides encoding same
AU2005269647B2 (en) Use of apoptosis-specific eIF-5A siRNAs and antisense polynucleotides to inhibit/suppress an inflammatory response
US7381708B2 (en) Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
JP5566250B2 (ja) ｅＩＦ−５Ａ１の発現を抑制するための、アンチセンス・オリゴヌクレオチド又はｓｉＲＮＡの使用
KR20070018146A (ko) 염증 반응을 저해/억제하기 위한 아폽토시스-특이적ｅＩＦ-5Ａ ｓｉＲＮＡ 및 안티센스 폴리뉴클레오타이드의이용

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application