KR20050089045A - Increasing skin cell renewal with water-soluble vitamin e - Google Patents

Abstract

The present invention relates to a method of enhancing the rate of skin exfoliation by incorporating a water-soluble Vitamin E derivative into a cosmetic composition that contains water and is suitable for application to mammalian skin. The composition has a pH from about 4.5 to 9 and can increase the rate of natural skin exfoliation by at least 10%.

Description

Increase of skin cell regeneration by water-soluble vitamin E {INCREASING SKIN CELL RENEWAL WITH WATER-SOLUBLE VITAMIN E}

This application is incorporated by reference in U.S. Pat.No. 6,645,514, filed Dec. 19, 2002, and US Attorney Docket No., filed Oct. 10, 2003. Claim priority of 3086/1421. The title of each document described above was "Increase of skin cell regeneration by water soluble vitamin E".

Human skin is continuously attacked by environmental conditions such as the sun, wind, and pollutants. These environmental attacks age the visible layer of skin and reduce the skin's ability to act as an effective barrier layer against the environment. This weathering causes undesirable conditions including wrinkles, age spots, roughness, scaling, flaking, uneven appearance, and uneven pigmentation. Moreover, the effects of natural aging also cause wrinkles on the skin.

This negative effect can be prevented or at least ameliorated by applying to the skin a cosmetic product containing an agent which is beneficial to the skin for increasing exfoliation according to the invention.

Human skin will be divided into two main parts. : Outer layer or epidermis and lower layer or dermis. The dermis includes, among other things, blood vessels, nerves, collagen, elastin and fibroblasts responsible for the biosynthesis of collagen and elastin.

The epidermis is thought to consist of two main zones. Inner or epidermal layer, and outer or stratum corneum. The inner maldermal layer will be further subdivided into living, basal, spinal, and granular layers. The outer stratum corneum is a dead tissue, also called the stratum corneum.

In the process of natural skin regeneration, the basal layer cells move outward from the basal layer and pass through the visible and granular layers to dead cells called keratinocytes in the stratum corneum. This process of producing keratinocytes is called keratinization. The stratum corneum consists of approximately 14 dead cells and is a skin tissue that feels when it comes into contact with the surface of the skin.

In normal skin, when naturally detached and exfoliated, it takes about 14 days for the basal layer cells to migrate from the basal layer to the ends of the granular layer and become keratinocytes, which again takes 14 days to reach the outermost of the stratum corneum. It takes Thus, it takes about 28 days for cells to migrate from the basal layer to the outer surface during skin regeneration.

Based on the understanding of this skin aspect, two conventional methods are used to improve the appearance of the skin through the application of topical compositions. First, the composition is applied to protect the living part of the skin from damage. Second, a composition is applied that increases the rate of natural exfoliation of the skin (the rate of cellular renewal), and thus increases the rate at which the outer dead cells' layers (stratum corneum) are replaced.

One traditional method of protecting live skin cells from oxidative damage is to apply a composition containing α-tocopherol (naturally occurring vitamin E) to the skin surface. Naturally occurring vitamin E can improve the appearance of the skin by penetrating the outer layers of the skin to protect living cells from oxidative attacks such as radicals and peroxides through fat soluble and continuous use. Additional fat-soluble vitamin E derivatives, including ester derived vitamin E, tocopheryl acetate, tocopheryl linoleate, tocopheryl linoleate / oleate, tocopheryl nicotinate, and tocopherol (vitamin E alcohol), are also oxidative It can act to protect living skin cells from Naturally occurring vitamin E and its fat soluble derivatives are believed to improve the appearance of the skin by reducing oxidative damage to living cells. These fat-soluble agents are not known to increase the rate of exfoliation (skin cell regeneration).

Unlike fat-soluble vitamin E derivatives, water-soluble vitamin E derivatives are known to prevent organ damage when administered to the body. US Pat. No. 6,022,867 discloses a water soluble vitamin E derivative, DL-α-tocopheryl phosphate (VEP). This derivative is prepared by reacting vitamin E with sodium phosphate. This' 867 patent discloses how to improve animal health when VEP is administered internally. Similarly, WO 93/15731 discloses how to prevent liver damage when phosphate induced vitamin E is administered internally to rats. Unlike the fat soluble vitamin E formulations of the prior art, VEP is water soluble.

Another traditional way to improve the appearance of the skin is to increase the natural exfoliation rate (cell regeneration rate) of the outermost part of the stratum corneum through application of exfoliation acid, thus exposing the lower layer of the stratum corneum. Unlike the previously discussed methods of protecting live skin cells with fat soluble vitamin E and its fat soluble derivatives, the exfoliating acid here hastened the natural exfoliation process by acting on dead skin cell layers. Many exfoliation acids are known to increase the rate of natural exfoliation. Exfoliating acids include glycolic acid, lactic acid, citric acid, malic acid, tartaric acid, salicylic acid, acetic acid, pyruvic acid, poly hydroxy acid (including gluconolactone and derivatives) and recent attention. Alpha and beta hydroxycarboxylic acids being received. Low molecular weight, short chain acids such as lactic and glycolic acids are the most widely used keratinizing acids in the cosmetic field.

A significant disadvantage of using an acid comprising hydroxycarboxylic acid as an exfoliant is that they are most effective at low pH of about 4.0 or less. Yu, RJ, et al., "Bioavailability of alpha-hydroxy Acids in Topical Formulations," Cosmetic Dermatology, Vol. 9, No. As disclosed in 6 (June 1996), acidic exfoliants are thought to deprotonate at a pH of about 3.8, thus losing their beneficial activity at higher pH due to lack of bioavailability. The inability of exfoliating acids to maintain their effect at high pH is described in Smith, WP, "Hydroxy Acids and Skin Aging," Soap / Cosmetics / Chemical Specialties, pp. 54-58, 76 (September 1993).

Another disadvantage of using exfoliating acids lies in the strong association that exists between their exfoliating capacity (increasing the rate of cell renewal) and the degree of skin irritation it causes. This increased stimulation will contribute to the acidity of the active ingredient. Therefore, for compositions that rely on exfoliating acid for increasing cell regeneration rate, the extent of exfoliation increases with increasing acidity and irritation. Thus, when used in practice, the amount of beneficial skin exfoliation that an exfoliating acid can deliver is not limited by the acid's exfoliating ability, often by how the composition can be applied to the skin without undue irritation.

As mentioned above, at pH of about 4.0 or less, exfoliating acid comprising hydroxycarboxylic acid demonstrates significant acceleration of cell regeneration associated with undesirable levels of skin irritation. However, when the pH of the acidic composition is increased by approaching neutral (7.0), cell regeneration rapidly decreases in addition to skin irritation. Accordingly, it is desirable to provide an exfoliating composition that increases the natural skin exfoliation rate without skin irritation associated with exfoliating acid. It would be most desirable to provide enhanced exfoliation of skin at a pH approaching more neutral to reduce skin irritation. The present compositions provide enhanced skin exfoliation with higher pH and lower irritation than traditional exfoliating acids, providing a significant disadvantage of acid exfoliants.

Summary of the Invention

In one aspect, the present invention provides a topical cosmetic or dermatological composition comprising a carrier comprising a water soluble vitamin E derivative and water. This water soluble vitamin E derivative is preferably a water soluble salt of vitamin E and is in the water phase.

In another aspect, a water soluble vitamin E derivative is present in the composition at an effective dose that increases the rate of natural skin exfoliation at a pH that significantly reduces skin irritation compared to prior exfoliation acids. This water-soluble vitamin E derivative speeds up the exfoliation of skin without undue irritation.

According to one aspect of the invention, there is provided a composition comprising a water soluble vitamin E derivative in a therapeutically effective dose in a topically usable carrier for application to human skin to increase the natural rate of skin exfoliation. Preferably, the composition contains about 0.05% to about 30% of water soluble vitamin E derivatives and has a pH in the range of about 4.5-9.

Another aspect of the invention is a skin exfoliation comprising topically applying a cosmetic composition containing an effective amount of a water soluble vitamin E derivative to enhance the exfoliation rate of skin cells above the naturally occurring exfoliation rate of skin cells. Methods of increasing the rate of removal. In this aspect, the method includes topically applying to the skin a composition comprising a water soluble vitamin E derivative at a dose and time sufficient to increase the rate of natural skin exfoliation.

<Detailed Description of the Invention>

The present invention relates to compositions that enhance the rate of skin cell regeneration or exfoliation and methods of increasing the rate of skin cell regeneration. This composition is believed to act by exfoliating or "release" of dead cells, rather than repairing or protecting live skin cells from damage, including oxidative damage from radicals and peroxides. Thus, the present compositions increase the release rate of dead keratinized cells; They are thought to contain living cells from damage.

By increasing the rate of exfoliation of mammalian skin, many advantages are obtained. In one aspect, the visible layer of the skin is refinished with an uneven appearance and reduced pigmentation. When hitting the skin with improved light, the skin looks "brighter" and healthier. In another aspect, increasing the exfoliation rate improves the skin feel, for example by reducing wrinkles, roughness, scales and dropping. By softening the skin feel, the appearance of the skin will be enhanced.

In particular, the present invention relates to a composition comprising a beneficial agent for the skin comprising a water soluble vitamin E derivative which promotes cell regeneration but does not excessively stimulate at a desired pH. If particularly preferred, the present invention includes compositions comprising sodium phosphate derived vitamin E (VEP). The present invention also relates to a method of increasing the rate of skin-cell exfoliation by applying a composition to the skin, wherein the composition comprises an effective dose of a water soluble vitamin E derivative and a carrier. According to one aspect of the present invention, a composition usable for topical application of the skin comprises a water soluble vitamin E salt and a carrier.

Water soluble vitamin E salts useful in the present invention include all enantiomers, single or in combination. With regard to salts, preferred salts include phosphates and sulfates, with phosphate salts being presently preferred. The cationic portion of the salt includes, but is not limited to, alkali and alkaline earth metals such as sodium, potassium, calcium and magnesium. The cations may be used alone or in mixture of two or more. Sodium is the preferred cation for salts.

Suitable water soluble vitamin E derivatives are, for example, sodium vitamin E phosphate (VEP), lauryl imino dipropionic acid tocopheryl phosphate, tocopheryl glucoside, tocopheryl succinate, tocophersolane (tocopheryl polyethylene glycol 1000 succinate ), Disodium lauliminodipropionate tocopheryl phosphate, tocopheret-5,10, 12,18, and 50 (polyethylene glycol (PEG) tocopheryl ether). Disodium lauliminodipropionate tocopheryl phosphate will be considered as the phosphate salt of its derivatives with vitamin E and beta-alanine functionality. For PEG vitamin E derivatives, the increased number indicates the increased number of PEG molecules attached to vitamin E. Thus, as the number increases, solubility also increases. Tocopheret-5 has the lowest water solubility and tocopheret-50 has the highest water solubility. Preferred water soluble vitamin E derivatives include sodium vitamin E phosphate (VEP), lauryl imino dipropionic acid tocopheryl phosphate, and disodium lauliminodipropionate tocopheryl phosphate.

To prepare a composition according to the invention, at least one or more of the aforementioned water soluble vitamin E salts are mixed with a carrier which can be used pharmaceutically or in cosmetics comprising water. Preferably, about 0.05% to about 30% of the composition is a water soluble vitamin E derivative, more preferably about 0.1% to about 15%. Currently, compositions comprising about 0.4% to about 5% of water soluble vitamin E derivatives are particularly preferred. Unless stated otherwise, all percentages are provided on a weight / weight basis.

Preferably, the carrier can assist in maintaining the required pH of the composition. The pH value of the composition of the present invention is about 4.5 to about 9, preferably 4.8 to 8.2, more preferably 5.6 to 7.9.

Although the difference in values in these pH ranges is small, the difference in acidity is significant due to the logarithmic (log) relationship between the numerical pH value and acidity. Thus, pH 5 is lower in pH in order of grade than pH 4.

Preferably, the water soluble vitamin E derivatives are not combined to form a composition comprising exfoliating acid, squalene, or squalane. "Squalane" is a saturated hydrocarbon formed by reduction of squalene, and squalene, an unsaturated hydrocarbon, is present in fish and vegetable oils. In another aspect, the composition does not include a sufficient exfoliation acid to provide an increase in exfoliation rate. In another aspect, the composition does not contain at least 2% exfoliation acid. In another aspect, the composition does not contain an exfoliating acid having a bioavailability of 4% or more, more preferably 1% or more.

The compositions of the present invention may be formulated in water-based solutions, gels, lotions, creams, ointments, oil-in-water emulsions, water-in-oil emulsions, or other pharmaceutically acceptable formulations. However, if the water-based composition contains an oil, the water soluble vitamin E salt is substantially in the water phase.

The cosmetically acceptable carrier comprises water and preferably acts as a carrier for diluents, dispersants, or other cosmetic raw materials present in the composition to promote their dispersion when the composition is applied to the skin. Preferably, the composition comprises 5 to 98% water, more preferably 80 to 98% water.

The compositions of the present invention may also contain various traditional cosmetic ingredients as long as they do not adversely affect the skin exfoliation enhancement or composition pH required. Suitable cosmetic raw materials include liquid or solid emollients, organic or inorganic sunscreens, preservatives, buffers, solvents, wetting agents, viscosity modifiers, alcohols, fats, oils, surfactants, fatty acids, silicone oils, humectants, emulsifiers, stabilizers, Colorants, perfumes. The claimed compositions may also include propellants such as propane, isobutane, dimethyl ether, carbon dioxide and nitric oxide.

As used herein, the term "emoliients" refers to materials used for the protection of the skin as well as for the reduction and prevention of drying. Sagarin, Cosmetics, Science and Technology, 2nd Edition, Vol. 1, pp. A variety of suitable softeners such as those disclosed in 32-43 (1972) are known and can be used herein.

The compositions may optionally contain inorganic and organic sunscreens as cosmetic raw materials that provide protection from the deleterious effects of excessive exposure to sunlight during use. In one aspect, the preferred composition comprises 0.1-10%, more preferably 1-5% of organic sunscreen.

Examples of suitable organic sunscreens include those provided in Table 1 below, and mixtures thereof.

CTFA Process Name product name producer Benzophenone-3 UVINUL ^® M-40 BASF Chemical Co. Benzophenone-4 SPECRA-SORB ^® UV-24 American cyanamide DEA methoxycinnamate BERNELHYDROO Bernel Chemical Ethyl dihydroxypropyl-PABA AMERSCREEN ^® P Amerchol Corp. Glyceryl PABA NIPA ^® GMPA Nipa Labs. Homosalate KEMESTER ^® HMS Hunko chemical Methyl anthranilate SUNAROME ^® UVA Felton worldwide Octocrylene UVINUL ^® N-539 BASF Chemical Co. Octyl dimethyl PABA AMERSCOL ^® Amerchol Corp. Octyl methoxycinnamate PARSOL ^® MCX Bernel Chemical Octyl salicylate SUNAROME ^® WMO Felton worldwide PABA PABA ^® National starch 2-phenylbenzimidazole-5-sulphonic acid EUSOLEX ^® 232 EM lndustries TEA Salicylate SUNAROME ^® Felton worldwide 3- (4-Methylbenzylidene) -campo EUSOLEX ^® 6300 EM Industries Benzophenone-1 UVINUL ^® 400 BASF Chemical Co. Benzophenone-2 UVINUL ^® D-50 BASF Chemical Co. Benzophenone-6 UVINULX D-49 BASF Chemical Co. Benzophenone-12 UVINUL ^® 408 BASF Chemical Co. 4-isopropyl dibenzoyl methane EUSOLEX ^® 8020 EM Industries Etocrylene UVINUL ^® BASF Chemical Co.

The claimed compositions may also contain inorganic sunscreens, which include, but are not limited to, titanium dioxide; Zinc oxide, average particle size 1-300 nm; Iron oxide, average particle size 1-300 nm; And silica, such as fumed silica, and an average particle size of 1 to 100 nm. The total dose of titanium dioxide that can be incorporated into the composition is 1-25%, preferably 2-10%, and ideally 3-7%.

It is also desirable to incorporate anti-inflammatory and / or anti-irritants in the claimed compositions. Natural anti-inflammatory and / or anti-irritants are preferred. For example, licorice and its extracts, dipotassium glycyrrhizinate, oat and oat extracts, candelilla wax, alpha bisabolol, aloe vera, Manjistha (manjistha) Rubia), in particular the puppet, is extracted from the plant of Cordidiorial), and Guggal (extracted from the plant of the genus Comipora, in particular of the genus Comnifora mukul).

It also has additional skin utility such as sphingolipids such as ceramides, glycoseramides, pseudoceramides, sphingomyelins, cerebromides, sulfamides, and gangliosides, sphingosine, dihydrosphingosine, phytosphingosine, and phospholipids. Benefit formulations may be incorporated separately or as a mixture into the claimed compositions. Fatty acids may also be combined with such dermal useful agents. For example, ceramides and glycoseramides include those described in US Pat. Nos. 5,589,178, 5,661,118, and 5,688,752. For example, water ceramide may be found in US Pat. No. 5,198,210; 5,206,020; And those described in 5,415,855.

According to one aspect of the present invention, the rate of natural skin exfoliation can be increased by topical application of the claimed compositions to the skin. In this regard, the present invention provides a natural skin exfoliation rate comprising topically applying a composition comprising a water-soluble vitamin E derivative (salt) to the skin in an amount sufficient to increase the natural exfoliation rate of the skin and for a sufficient time. Includes ways to promote. In another embodiment, the vitamin E salt is provided in a carrier comprising water that can help maintain the desired composition pH.

In general, topical compositions are applied on a daily basis at least daily and may be applied for any suitable period of time. Compared to traditional acidic (pH ≦ 4.0) compositions, the compositions of the present invention can be applied on a more regular basis with substantially reduced irritation to the skin. While not wishing to be bound by any theory, the reduction in skin irritation achieved during the enhanced exfoliation that a claimed composition can provide is such that the composition has a closer pH and higher pH to human skin's pH (pH-5). I think I can contribute to that. By routinely applying the present composition to the skin, within a few days the user can feel improved skin feel and smoothness with reduced irritation.

Table 3 describes a comparative study between cell-regeneration rate between water soluble vitamin E derivatives (VEP, sodium-phosphate salt) and traditional exfoliating acid (lactic acid). Skin irritation, expressed as a percentage of "sting", was also determined. The increase in skin cell regeneration rate and stimulation levels was described in September 1993, in "Soap / Cosmetics / Chemical Specialties" pp. Substantially measured according to the procedure described on pages 54-58 and 76.

Active additives Volume (% by weight) Composition (pH) Cell-Regeneration Rate (%) Stimulation level (% stimulation) Lactic Acid 5 3 31.7 194.7 VEP 0.5 5.65 15.2 17.3 VEP 1.0 7.21 16.6 10.7 VEP 2.0 7.78 22.8 24.0 VEP 2.0 7.78 21.4 37.3

As shown in the table, when comparing VEP with lactic acid control, beneficial cell-regeneration rate is achieved at surprisingly low stimulation percentages. This result clearly demonstrates that skin exfoliation (% cell-renewal rate) increases with higher concentrations of VEP and increasing pH. Therefore, the ability of water-soluble vitamin E to exfoliate at pH levels above 4.0, where traditional acidic exfoliants lose their activity. The previously described exfoliating acids such as lactic acid, salicylic acid, and alpha and beta hydroxycarboxylic acids are commonly thought to be effective exfoliants, and the water soluble vitamin E derivatives will function as effective exfoliants at high pH above 4.5. The discovery that it could be very surprising.

It is clear from this document that the compositions of the present invention can provide a beneficial exfoliation rate above pH 4.5. Indeed, preferred cell regeneration rates are observed at about pH 5.6 and above, and at about pH 7.2 and above. This is quite surprising because traditional exfoliants not only lose their effect above pH 4.0, but also provide increased exfoliation rates as the pH decreases. In contrast to traditional exfoliants, the compositions of the present invention provide beneficial exfoliation above pH 4.5, and their exfoliation performance continues to increase as the pH is raised—the result is in accordance with the results achieved with traditional acidic compositions. It is completely opposite and unexpected.

The stimulus results are somewhat subjective, as evidenced by the variables between the results with a VEP of 2.0 (% by weight) in Table 3, but the results show that VEP is somewhat slower than lactic acid in cell-regeneration, but for skin It is clearly shown that at least 4.5 times is less irritating. Indeed, at pH 7.21, for example, the composition is about 1/20 in stimulation to the skin. Preferably the claimed compositions can reduce consumer-aware skin irritation (% stimulus) by 25% or more and more preferably at least 50% or more, with respect to the results achieved with exfoliating acids having a pKa of 4.0 or less. .

Because of the significantly reduced skin irritation provided by water soluble vitamin E derivatives in connection with exfoliating acids, the present compositions can be used more frequently and more regularly than traditional acid-based exfoliating compositions to improve skin. Therefore, when compared to a composition containing an exfoliating acid, the present composition can be used in practice to increase the skin cell-regeneration rate as a whole. This is because the claimed compositions can be applied more often with reduced stimulation.

The following describes examples of formulations according to the present invention. Although the examples use only selected compounds and formulations, it should be understood that the following examples are illustrative only and are not intended to limit the invention.

Table 4 shows some examples of suggested solution and / or gel formulations that fall within the scope of the present invention and provide amounts expressed in weight percent.

additive A B C D water 80.25 75.00 79.00 81.65 VEP 0.5 1.0 2.0 2.0 Butylene Glycol 2.0 1.0 3.0 3.0 PEG-8 2.0 glycerin 1.0 2.0 2.0 4.0 Glyceres-26 1.0 2.0 2.0 Sodium Hyaluronate (0.5% Solution) 0.2 0.4 0.2 Dipotassium Glycisinate 0.01 Panthenol 0.25 0.25 0.5 Oat extract 2.0 1.0 Cucumber extract 2.0 1.0 Alcohol 2.0 8.0 4.0 Thickeners, Extracts, Preservatives, Emulsifiers, Skin Conditioners, Neutralizers 8.79 8.35 6.0 8.65 gun 100.00 100.00 100.00 100.00

Table 5 shows some examples of emulsion, cream, and / or lotion formulations that fall within the scope of the present invention and are presented in amounts given in weight percent.

additive A B C D water 59.6 58.36 70.42 67.25 VEP 0.5 1.0 2.0 2.0 Silicone rubber 25.0 4.0 Butylene Glycol 4.0 1.5 5.0 glycerin 1.0 0.5 1.0 0.5 Glyceres-26 1.0 2.0 Sodium Hyaluronate (0.5% Solution) 0.50 0.50 0.50 Dipotassium Glycisinate 0.02 0.01 Panthenol 0.1 0.05 0.1 C 12-15 Alkyl Benzoate 5.0 2.0 Tocopherol 0.1 0.05 0.1 Caprylic / Capric Triglycerides 5.0 Octyl methoxycinnamate 2.0 GMS & PEG-100 Stearate 5.0 4.25 5.0 Cetyl alcohol 1.0 2.5 Titanium dioxide 3.5 Tetrasodium EDTA 0.2 0.1 0.2 Oat extract 5.0 0.5 1.0 Phospholipids, sphingolipids, cholesterol 1.0 0.5 0.35 0.1 Thickeners, extracts, preservatives, emulsifiers, skin conditioners, neutralizers 6.9 17.72 7.77 14.75 gun 100.00 100.00 100.00 100.00

It should be understood that a wide range of changes and modifications can be made to the compositions and methods of the present invention. Therefore, the foregoing description is intended to explain rather than limit the invention, and only the following claims, including all equivalents, will limit the invention.

Claims (20)

Mammalian skin exfoliation rate enhancement composition comprising the following. : 0.05% to 30% sodium vitamin E phosphate, lauryl imino dipropionic acid tocopheryl phosphate, tocopheryl glucoside, tocopheryl succinate, tocophersolan (tocopheryl polyethylene glycol 1000 succinate), beta-alanine functional groups Water-soluble vitamin E derivatives selected from the group consisting of vitamin E derivatives having, tocopheret-5, 10, 12, 18, and 50, and mixtures thereof; And A carrier comprising water; Wherein the composition has a pH of about 4.5-9 and the water soluble vitamin E derivative is substantially in water. The method of claim 1, wherein the water-soluble vitamin E derivative is selected from the group consisting of sodium vitamin E phosphate, lauryl imino dipropionic acid tocopheryl phosphate, vitamin E derivatives having beta-alanine functional groups, and mixtures thereof. Mammalian skin exfoliation rate enhancement composition, characterized in that it is. According to claim 1, wherein the composition is mammalian skin exfoliation speed enhancing composition, characterized in that it does not contain squalene or squals. The composition of claim 1, wherein the water soluble vitamin E derivative comprises sodium vitamin E phosphate. The composition of claim 1, wherein the water soluble vitamin E derivative comprises disodium lauliminodipropionate tocopheryl phosphate. The composition of claim 1, wherein the composition comprises 0.1% to about 15% of a water-soluble vitamin E derivative. The composition of claim 1, wherein the composition comprises 0.4% to about 5% of a water soluble vitamin E derivative. The method of claim 1, wherein the carrier further comprises a cosmetic ingredient (cosmetic ingredient), the composition for improving the speed of exfoliation of mammalian skin. The composition of claim 1, wherein the composition has a pH of 4.8 to 8.2. According to claim 1, wherein the composition is a mammalian skin exfoliation speed enhancing composition, characterized in that having a pH of 5.6 ~ 7.9. The composition according to any one of claims 1 to 10, which is used for the manufacture of pharmaceutical, dermatological, topical, or cosmetic compositions for enhancing the speed of natural mammalian skin exfoliation. 12. The composition of claim 11, wherein said natural mammalian skin exfoliation rate is accelerated by at least 10%. 12. The composition of claim 11, wherein said natural mammalian skin exfoliation rate is accelerated by at least 15%. The composition of claim 11, wherein the% sting is reduced by at least 25% compared to exfoliating acids having a pKa of 4.0 or less. 12. The composition of claim 11, wherein the% sting is reduced by at least 50% compared to exfoliating acids having a pKa of 4.0 or less. 12. The composition of claim 11, wherein the natural exfoliation rate is accelerated by at least 10% and the sting is reduced by at least 25% compared to exfoliating acids having a pKa of 4.0 or less. 12. The composition of claim 11, wherein the natural skin exfoliation rate is accelerated by at least 20%, and the percent sting is reduced by at least 50% compared to exfoliating acids having a pKa of 4.0 or less. The composition of claim 11, wherein the pharmaceutical, dermatological, topical, or cosmetic composition is prepared as a solution, gel, lotion, cream, or ointment. 12. The composition of claim 11, wherein said enhanced exfoliation rate enhances the feel of mammalian skin. 12. The composition of claim 11, wherein said enhanced exfoliation rate refinish mammalian skin.