KR20050041745A - A nonperishable agent and cosmetic composition containing the same - Google Patents

Abstract

The present invention relates to a preservative capable of preventing damage due to corruption to microorganisms, the preservative according to the present invention consists of 1,2-hexanediol (1,2-hexanediol) represented by the following formula (1). 1,2-hexanediol has excellent antibacterial and antiseptic properties, and thus shows excellent effects as a preservative, and has little side effects on the skin, and thus can be usefully added as a preservative to cosmetics and the like.

Description

Preservatives and cosmetics containing the same {A nonperishable agent and Cosmetic composition containing the same}

The present invention relates to a preservative used to prevent damage due to decay of microorganisms in products such as cosmetics and cosmetics containing the same.

Most cosmetics are composed of various raw materials such as cosmetic oils, surfactants, inorganic powders, organic water-soluble polymers, and fragrances, so they are suitable for growth of microorganisms. Therefore, it is recommended to add chemical preservatives to prevent corruption by microorganisms. It is common.

As preservatives currently used in cosmetics, imidazolidinyl urea, phenoxyethanol, paraoxybenzoic acid esters, DM diem hydantoin, benzalkonium chloride and the like are generally used. Recently, as new additives such as proteins, gums, vitamins, and medicinal plants are added, changes caused by the action of microorganisms are also diversified, and thus the amount of preservatives added due to the weakening of preservative function is increasing.

As such, as the amount of the preservative increases, the skin irritation and allergic symptoms are caused to adversely affect the skin of the user. Therefore, there is an urgent need for the development of a preservative having sufficient preservative power without any side effects on the skin.

Therefore, the technical problem to be achieved by the present invention is to provide a preservative and a cosmetic containing the same to solve the above problems, excellent antibacterial and antiseptic properties, excellent effect as a preservative, as well as almost no side effects on the skin.

In order to achieve the above technical problem, the present invention provides a preservative consisting of 1,2-hexanediol (1,2-hexanediol) represented by the following formula (1).

<Formula 1>

       The present invention also provides a cosmetic comprising the preservative consisting of the 1,2-hexanediol (1,2-hexanediol) as an active ingredient.

In the cosmetic according to the present invention, the content of 1,2-hexanediol (1,2-hexanediol) is preferably 0.01 to 40% by weight based on the total weight of the cosmetic.

Hereinafter, the preservative of the present invention and the cosmetic containing the same will be described in detail.

The inventors of the present invention, while researching a substance that does not irritate the skin and have sufficient preservative power when added to a product such as cosmetics, 1,2-hexanediol, one of the polyol compounds having a moisturizing function is excellent antibacterial and antiseptic In addition, it has been found to be very useful as a preservative because it has no side effects on the skin. Thus, 1,2-hexanediol according to the present invention skin, lotion, cream, foundation, essence, gel, pack, foam cleanser, softening lotion, astringent makeup, mascara, eyeliner, shampoo, rinse, soap, body cleanser, When added to cosmetics such as hair dressing and woolen, it is conserved for a long time and has no side effects when used on the skin.

1,2-hexanediol as a preservative according to the present invention is a colorless transparent liquid, so that it is easily dissolved in water and ethanol, it can be applied to a wide range of formulations, such as emulsions, emulsions, gels, pastes as well as aqueous solutions.

 The amount of 1,2-hexanediol added is preferably 0.01 to 40% by weight, more preferably 0.5 to 5.0% by weight based on the total weight of the cosmetic, and is used as phenoxy ethanol and paraben organic acid preservative. And other preservatives.

Hereinafter, the present invention will be described in detail with reference to Examples. However, embodiments according to the present invention can be modified in many different forms, the scope of the present invention should not be construed as limited to the embodiments described below. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Antimicrobial Effect Experiment

The strains of Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 10536, and Pseudomonas aeruginosa ATCC 15522 are used for brain heat infusion liquid medium. Pre-culture at 35 ° C for 24 hours. The prepared and sterilized brain heart infusion liquid medium was put in 100 ul into each well of a 96-well, U-form micro plate (Falcon, USA). 1,2-hexanediol (1,2-hexanediol) step by step dilution by concentration, inoculated to 10 ⁵ ~ 10 ⁶ CFU / ml. The treated 96-well, U-form micro plates were then incubated for 24 hours in a 37 ° C. incubator.

Propionibacterium acnes ATCC 6919 strains were pre-incubated for 48 hours in a 35 ° C anaerobic incubator using a brain heart infusion liquid medium. Sterile brain heart infusion liquid medium was added to each 100-well of 96-well, U-form micro plate (Falcon, USA). Dilute 1,2-hexanediol by concentration, 10 ⁵ ~ 10 ⁶ CFU inoculated to / ml. The treated 96-well, U-form micro plates were then incubated for 48 hours in a 37 ° C. anaerobic incubator.

Candida albicans ATCC 10231 was precultured at 30 ° C. for 48 hours using sabouraud dextrose liquid medium. Pre-prepared and sterilized sabouraud dextrose liquid medium was added to each 100-well of 96-well, U-form micro plate (Falcon, USA). Pre-prepared 1,2-hexanediol by step dilution by concentration, 10 ⁵ CFU inoculated to / ml. Subsequently, the treated 96-well, U-form micro plates were incubated for 48 hours in a 30 ° C. incubator.

Aspergillus niger ATCC 9642 ) Was incubated at 30 ° C. for 5 days using a sabouraud dextrose solid medium. Pre-prepared and sterilized sabouraud dextrose liquid medium was added to each 100-well of 96-well, U-form micro plate (Falcon, USA). 1,2-hexanediol was diluted by concentration and inoculated to 10 ⁵ CFU / ml. Subsequently, the treated 96-well, U-form micro plates were incubated in a 30 ° C. incubator for 5 days. By visually checking each well, the lowest concentration of the sample without bacterial growth was determined by MIC.

In the case of Aspergillus niger , the lowest concentration at which no mycelium was formed on the surface of the medium after 5 days of incubation was determined by MIC.

Table 1 shows the minimum inhibitory concentration of 1,2-hexanediol for each strain.

Referring to Table 1, it can be seen that 1,2-hexanediol shows considerable antibacterial activity against a wide range of strains.

Antiseptic test

As a preservative, cosmetics of the examples in which 1,2-hexanediol was added to lotions, sunscreens, foundations, and foam cleansers and comparative cosmetics in which no 1,2-hexanediol was added were prepared. ~ 12 and 40g each of the cosmetics, and then mixed bacteria such as Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15522, Escherichia coli ATCC 10536 Was added to the sample so that 10 ⁶ grains per gram of the sample was mixed and stored for 4 weeks. Then, each time 1 day, 7 days, 14 days, 21 days, 28 days elapsed from the day of inoculation of the change of the number of inoculated bacteria, the result of the measured antiseptic force was shown in Tables 6-13.

Aspergillus niger ATCC 9642 for fungus and Candida albicans ATCC 10231 for yeast were mixed and added to the sample to 10 ⁵ per gram. Checks were made each day after 1 day, 7 days, 14 days, 21 days, and 28 days.

The described embodiments are merely the most preferred and do not represent all of the technical parts of the present invention, and it should be understood that there may be various equivalents and modifications that may replace them at the time of the present application.

Referring to Tables 6 to 13, the cosmetics containing 1,2-hexanediol according to the present invention as a preservative showed antiseptic force comparable to the cosmetics of the comparative example containing a conventional chemical synthetic preservative.

Primary irritation test on human body (closed patch)

In order to evaluate the safety and stimulation of the human body using the lotion cosmetics of Comparative Example and Example 3 of Table 2, the first stimulation test was performed on the human body through a human patch test as follows. CTFA guidelines for 50 healthy men and women [Ref. The Cosmetic, Toility and Fragrance Association. Inc. Washington, D.C., 20036, 1991]. 15 μl of the sample and the solution were added dropwise to the Finn Chamber, which was placed on the back of the human body, which was the test site, and fixed with tape. Subsequently, after patching for 24 hours, after removing the patch and passing 4 hours again, the skin reaction of the test site was judged according to the following criteria, and the results are shown in Table 14.

<Judge criteria>

-; No erythema or unusual symptoms

±; Slightly redder than the surroundings

+; Significantly redder than the surroundings

+ +; Severe redness and swelling than around

Stimulation degree = [{(±) number × 1} + {(+) number × 2} + {(++) number × 3}] / number of subjects

As shown in Table 14, it can be seen that the cosmetic containing 1,2-hexanediol according to the present invention as a preservative has a much lower skin irritation than the cosmetic of the comparative example containing a conventional chemical synthetic preservative.

As described above, the 1,2-hexanediol according to the present invention has excellent antibacterial and antiseptic properties, and thus has an excellent effect as a preservative, and has almost no side effects on the skin, and thus can be usefully added as a preservative to cosmetics and the like.

Claims (4)

Preservative consisting of 1,2-hexanediol (1,2-hexanediol) represented by the formula (1). <Formula 1> Cosmetics characterized in that it contains a preservative consisting of 1,2-hexanediol (1,2-hexanediol) represented by the formula (1) as an active ingredient. <Formula 1> The cosmetic according to claim 2, wherein the content of 1,2-hexanediol is 0.01 to 40% by weight based on the total weight of the cosmetic. The method of claim 2, wherein the cosmetic is a skin, lotion, cream, foundation, essence, gel, pack, foam cleanser, softening lotion, astringent makeup, mascara, eyeliner, shampoo, rinse, soap, body cleanser, hair dressing and wool Cosmetics, characterized in that consisting of any one formulation selected from the group consisting of.