KR20050023118A - Composition for relieving hangover and improving liver function - Google Patents

Abstract

PURPOSE: A composition for relieving hangover and improving liver function and a preparation method thereof are provided, which composition reduces alcohol concentration and acetaldehyde concentration in blood after 30 minutes have passed since men drank, and relieves hangover including headache, heart beating, emotion anxiety, fatigue, nausea feeling, sleepiness, discomfort of the abdomen, thirst and enervation. CONSTITUTION: The composition for relieving hangover and improving liver function comprises Artemisia capillaris Thunb., Pueraria thunbergiana, Hovenia dulcis thunb, Silybum maxianum, Atractylodis Rhizoma alba, Polyporus umbellatus FRIES., Poria cocas WOLF, Citrus unshiu MARKOVICH., Panax schinseng and Lycium chinense MILL. The method for preparing the composition for relieving hangover and improving liver function comprises the steps of: mixing Artemisia capillaris Thunb., Pueraria thunbergiana, Hovenia dulcis thunb, Atractylodis Rhizoma alba, Polyporus umbellatus FRIES., Poria cocas WOLF, Citrus unshiu MARKOVICH., and Lycium chinense MILL. and heating the mixture in water at 80 to 100 deg. C for 16 hours; concentrating the heated mixture at 50 to 70 deg. C under vacuum condition; adding Silybum maxianum and Panax schinseng concentrate into the concentrated mixture and mixing them.

Description

Composition for relieving hangover and improving liver function {Composition for relieving hangover and improving liver function}

The present invention relates to a composition for relieving hangovers and improving liver function, and more particularly, to a composition for relieving hangovers and improving liver function, mainly comprising herbal herbal medicines.

Alcohol consumed by drinking is easily absorbed by the gastrointestinal tract, of which only 2-10% is excreted through the lungs and kidneys, and the remaining 90-98% is mainly oxidized in the liver. Alcohol from the liver is mainly oxidized through the alcohol dehydrogenase system in the cytoplasm, but also through the ethanol oxidation system in the microsomes. Alcohol affects carbohydrates and fat metabolism, causing metabolic disorders such as hyperacidemia and hyperlipidemia, inhibiting the oxidation of fatty acids in hepatocytes, increasing the synthesis of triglycerides, forming fatty liver, and progressing to cirrhosis. Alcohol also penetrates the cerebrovascular walls, leading to mental discomfort and cranial nerve disorders.

Acute alcoholism, called hangovers, clinically primarily affects the digestive and nervous systems. Symptoms of the digestive system are nausea and vomiting in the morning, which are characterized by calming after drinking one or two drinks, which are considered mild symptoms of withdrawal symptoms. Other symptoms of the gastrointestinal system include bloating, lower abdominal pain, burping, and ulcers. The most common pathological finding of this symptom is superficial gastritis, which is a sequelae that almost anyone gets from drinking alcohol. Gastritis is mostly benign and symptoms subside within a few days, but in severe cases mucosal erosions, ulcers, and severe bleeding can occur.

Chronic alcoholism, on the other hand, can lead to liver disease such as fatty liver or withdrawal symptoms. So-called alcoholism (alcoholism) is a representative chronic alcoholism.

In oriental medicine, the symptoms caused by alcohol are called alcohol. Alcohol is said to be 大 熱 大 毒. In other words, alcohol is so enthusiastic that it does not freeze below freezing, and when people drink it is toxic enough to disturb the mind and change the character.

The description of the oriental medical stage for the columnar is as follows.

The first is when disturbances occur and major symptoms occur. Judo poisoning generally means reading, which comes from the great character of alcohol. Alcohol poisoning (熱 毒) is usually excreted through the skin or sweat, and if the poison is not discharged well due to excessive drinking or continuous drinking, the poison is accumulated in the body meridians or books, causing various diseases. In addition, heat poisoning consumes body fluids, which causes secondary diseases.

The second is when symptoms occur due to disorders in water metabolism. Drinking too much water due to excessive drinking, continuous drinking, or thirst caused by drinking damages the stomach and causes various diseases.

Third, the main symptoms are caused by ulceration and abnormal sap.

Chongqing, which began to treat alcohol disorders in earnest, used a method of reducing the heat and dissolving poisoning by causing alcohol-related disorders mainly in the liver. Since then, the treatment of alcoholism has been defined as the primary treatment for sweating and diuresis, and the origins go back to the price of Geumwon. Heo-Jun's consent, which was influenced by Kumwon Corp., began to describe the temporary and chronic alcoholic disorders and suggested the corrective measures. The late Chosun Dynasty articles, which focus on first aid, mainly describe how to treat acute alcohol disorders. Most of them originate in consent and the rationale and treatment do not escape consent.

Accordingly, an object of the present invention is to provide a herbal composition that is effective in releasing alcohol, urinate well, and gastrointestinal supplements, which are effective for liver disorders caused by hangover and alcohol. It is.

The object of the present invention is Injin ( Artemisia capillaris ), Pueraria thunbergiana , Hovenia dulcis , Silybum maxianum , Artractylodes macrocephala , Polyporus umbellatus , Poria cocos , and dermis It is achieved by the composition for relieving hangover and improving liver function, including Citrus unshiu ), red ginseng ( Panax schinseng ) and Goji ( Lycium chinense ).

The efficacy of each of the constituent herbs will be described.

(1) Efficacy of Injin

◎ The heat of alcohol (술) to send along the urine to release the liquor accumulated in the liver, and jaundice excellent treatment effect. (Herbology)

◎ lowers the heat and makes the urine come out well, and it is effective for skin diseases and cures jaundice. (Chinese medicine dictionary)

◎ Heals fever and eliminates jaundice. Promotes bile secretion, hepatocyte regeneration, antipyretic and microbial growth, blood pressure lowering, diuretic.

(2) the effect of browning

◎ due to hangover fever, chest tightness, thirst, anorexia, vomiting and blood vomiting, rectal ulcer bleeding is treated. (Chinese medicine dictionary)

◎ relieve poison (酒 毒), fever after drinking, food does not come out, nausea, vomiting blood, seeing blood stools to treat the symptoms.

(3) Efficacy of the earth

◎ relieve hangover, chest heat, thirst, faeces are not treated well. (Chinese medicine dictionary)

◎ Remove the hangover, chest heat, thirst, vomiting, faeces are used for the symptoms are not good.

(4) efficacy of lightening

◎ to promote gastrointestinal function, to give energy, and to help sap metabolism, various gastrointestinal diseases are treated. Appetite, such as loss of appetite, indigestion, diarrhea, swelling can be effective. (Herbology)

◎ gastrointestinal function, the body fluids dry excessively and harmonizes the stomach (脾胃). A weak stomach, lack of appetite, boredom, powerless, flatulence is effective for the symptoms. Treat diarrhea, edema, jaundice, limb numbness, urination problems, dizziness, and sweating. (Chinese medicine dictionary)

◎ to keep the stomach and harmonize the function of the stomach. Feels tired, boredom, used for symptoms such as flatulence, diarrhea, edema, jaundice, sweating.

(5) the efficacy of the ghost

◎ It is an important medicine commonly used to treat urination disorders and edema by smoothing the discharge of water. It can be used for all symptoms of stagnant fluid, and is also best for people with a high fever. (Herbology)

◎ diuretic effect. Treat urinary symptoms, swelling, keratosis, diarrhea, gonorrhea, and bloating. (Chinese medicine dictionary)

◎ diuretic. Used for edema and urinary disorders.

(6) Efficacy of the ghost

◎ It is soft and weakens the stomach, stabilizes the mind, and has the effect of diuresis, so it can be applied to all symptoms of stagnation caused by gastrointestinal disorders. Such characteristics are soft and rewarding, and diuretic, but not vicious, the symptoms of the ghost is almost no side effects. (Herbology)

◎ It releases moisture, benefits the spleen, harmonizes the stomach, and stabilizes the mind. Urinary symptoms, swelling, cough, sputum, vomiting, diarrhea, oil well (遺精), gonorrhea, forgetting to treat. (Chinese medicine dictionary)

◎ has a diuretic effect, to see the stomach, to stabilize the mind. Used for urinary disorders, edema, diarrhea, vomiting, forgetfulness, etc. According to pharmacological analysis, diuretic, antibacterial action. Lower blood sugar

(7) Efficacy of the dermis

◎ Communicating a stagnant body makes the stomach become healthy by itself, and if you remove the water warmly, the phlegm is extinguished. Therefore, it is important for the communication of the body, harmony of the gastrointestinal function, water discharge, and removal of the phlegm. Is about. (Herbology)

◎ It communicates energy, harmonizes gastrointestinal function, releases moisture and removes phlegm. Treats anorexia, digestive problems, hiccups caused by vomiting, coughing and sputum. Also detoxify fish and crabs. (Chinese medicine dictionary)

(8) Benefits of Red Ginseng

◎ spleen and lungs to enter the spleen and lungs is an important medicine. The spleen is the source of nutrition and the lungs are in charge of the body's qi, and when the ulcer is satisfied, the whole body's qi becomes vigorous, and it relieves thirst, and when the vigor is satisfied, it can bring about the effect of relief. Applicable to all of the lack of energy caused by long illness. (Herbology)

◎ It greatly relieves the qi and creates moisture and relieves (安心). Overwork, weakness, loss of appetite, boredom, vomiting, diarrhea, coughing and shortness of breath, excessive sweating, palpitations, forgetfulness, dizziness, headache, erectile dysfunction, urinary disorders, exhaustion, uterine bleeding in children, cramps in children, Treats weakness that does not recover for a long time, lacks all the blood donation. (Chinese medicine dictionary)

◎ Daebowongi (大補 元氣) Efficacy, and is used for exhaustion, thirst, anxiety, various intestinal ischemia.

(9) Efficacy of the defense system

◎ Lower the fever, detox, and liver and phlegm.

◎ If you take a defense system, alcohol, chemicals, environmental poisoning caused by toxic liver damage can be treated, chronic hepatitis, liver cirrhosis can be treated. It also treats liver damage caused by arachnoid amoeba protozoa.

(10) Efficacy of wolfberry

◎ god, and also raise liver blood (肝血) to brighten the eyes, so the liver and kidneys are important medicine to replenish. It is a medicine that can in general relieve various kinds of kidney ischemia. (Herbology)

◎ make the kidneys and lungs moist, liver and brighten the eyes. It treats the tingling and weakness of the lower back and knees, dizziness, dizziness, dizziness of the eyes, sore eyes and tears, frequent cough due to pulmonary tuberculosis, and small thirst. (Chinese medicine dictionary)

◎ make the kidneys and lungs moist, liver and brighten the eyes. Heals various diseases of the liver, kidneys and lungs. Goji has a pharmacological action to prevent and treat fatty liver.

In the above regimen, the crater, the earthjaja acts to detoxify the damage of the liver caused by alcohol, and to treat the burning of the chest caused by excessive drinking, dry mouth, vomiting, stool discomfort, vomiting symptoms.

Human and defense systems improve liver function and increase bile secretion. In addition, it preserves liver function and has a hepatocyte regeneration effect, and is effective in hepatic diseases such as hepatitis, cirrhosis, addictive liver damage and jaundice.

Baekchul, Bokryeong, dermis to remove unnecessary water and to protect the stomach, alcohol, gastrointestinal disorders including nausea, urinary edema, edema, jaundice, anorexia, etc. are effective.

Goji to the lungs, spleen, liver, kidneys and moisturizes, red ginseng acts as a great aid, thirst removal, so this drug can be used to improve the therapeutic effect of alcohol-damaged blood donation (補) evenly.

In general, the prescription of the present invention is to relieve the poison, alcohol is effective in hangovers, lowers the heat, the stomach and liver to act and boosts the energy, so drinking, chronic alcoholism caused by drinking It can cure and effectively prevent and treat alcohol-induced liver damage and gastrointestinal disorders.

The composition of the present invention is a mixture of phosphorus, gallium, earth, Baekchul, Haeyeong, Bokryeong, dermis, goji berry hot water extraction at 80-100 ℃ over 16 hours in the extraction tank and then vacuum applied at a temperature of 50-70 ℃ After concentration, red ginseng extract and a hydrophobic system are added and mixed. The composition of the present invention, jinjin, hwahwa, earth, baekchul, ghost, bokyeong, dermis, gojija to prepare a 30ml concentrate using dry weight of 1-10g, respectively, the defense system and red ginseng are hot water export of the seven kinds of medicinal herbs, Based on 30 ml of concentrate, water-based system (milk thistle) 100-300 mg: 70-210 mg based on silymarin, red ginseng concentrate 0.25-1% (v / v): 5.25-20.1 mg based on red ginseng saponin .

The present invention will be described in more detail with reference to the following Examples.

Example 1 Preparation of Concentrate

Mix 7.5g of phosphorus, 4.5g of browning, 4.5g of earth, white ginseng, 2g, seongi 2g, Bokryeong 2g, dermis 2g, wolfberry 2g, add 200ml of water and heat to 100 ℃ Concentrate to 30 ml in vacuo at ℃ and concentrate the extract concentrate (milk thistle) 195 mg: silymarin based 140 mg, red ginseng concentrate 0.5% (v / v): red ginseng saponin based 10.5 mg mixed final product Packed. The composition of Example 1 of the present invention is hereinafter referred to as JBU.

Experimental Example 1 Alcohol Concentration

Six-week-old male Sprague-Dawley (SD) rats were purchased from Biolink for 1 week of pre-solid breeding with Samyang blended feed and water, and then experimented with two models. The environment of animal breeding was adjusted to a temperature of 23 ± 1 ° C. and a humidity of 50 ± 5%, and maintained a 12-hour contrast cycle. In order to determine the effect of the composition of the present invention on hangover, blood alcohol concentration was measured over time after alcohol intake. The experimental design of animals was divided into a control group administered with distilled water, a group administered with the composition of the present invention, and a PC (positive control) group administered with a hangover-relaxed beverage that is commercially available. g / kg) was collected from the rat vein 1, 3, 5, 7 hours after oral administration and treated with EDTA, and then alcohol content in whole blood using Sigma Alcohol Diagnostic Kit (# 332-UV). Was measured. To 0.2 ml of whole blood, 1.8 ml of trichloroacetic acid solution was added and mixed slowly. After standing at room temperature for 5 minutes, centrifuging at 2,000 rpm for 5 minutes, separating supernatant, mixing 0.1 ml of supernatant and 2.9 ml of NAD-ADH solution for 10 minutes at room temperature, and absorbing at 340 nm. Was measured. The mean values for the five horses are reported in Table 1 below and in FIG. 1. All results are expressed as mean ± standard error (SE).

Table 1

Aid Blood alcohol level (%) 0 hours 1 hours 3 hours 5 hours 7 hours Control 0.000 ± 0.000 0.120 ± 0.022 0.123 ± 0.021 0.115 ± 0.029 0.123 ± 0.033 JBU (1 ml / kg) 0.000 ± 0.000 0.056 ± 0.007 0.053 ± 0.027 0.047 ± 0.026 0.039 ± 0.019 JBU (2 ml / kg) 0.000 ± 0.000 0.060 ± 0.013 0.037 ± 0.016 0.021 ± 0.015 0.012 ± 0.009 PC (6.25ml / kg) 0.000 ± 0.000 0.082 ± 0.007 0.033 ± 0.009 0.011 ± 0.004 0.002 ± 0.002

The blood alcohol concentration increased to 0.12% in 1 hour in the control group after alcohol consumption. In the case of taking 1 ml / kg of the composition (JBU) of Example 1 before alcohol intake, the blood alcohol concentration was decreased by 53% at 1 hour, 57% at 3 hours, 59% at 5 hours, and 68% at 7 hours. When 2 ml / kg of the composition (JBU) of Example 1 was taken, it was rapidly reduced by 50% at 1 hour, 70% at 3 hours, 82% at 5 hours, and 90% at 7 hours, compared to the control group. As a positive control (PC: positive control), a commercially available hangover improvement product was used. When the composition of Example 1 was taken at 2 ml / kg, the positive control group showed better efficacy than the 6.25 ml / kg dose.

Experimental Example 2 Acetaldehyde Concentration

Under the same conditions as in Experimental Example 1, the concentration of acetaldehyde, which is an alcohol metabolite, after 180 minutes of alcohol treatment was measured, and the average value of the five was shown in Table 2. All results are expressed as mean ± standard error (SE).

TABLE 2

Minutes after alcohol treatment Acetaldehyde concentration in blood (mg / l) Control JBU (1 ml / kg) JBU (2 ml / kg) PC (6.25ml / kg) 180 1,022 ± 267 255 ± 30 141 ± 17 296 ± 25

Significant concentrations of acetaldehyde in blood were 75% (p <0.05) and 86% (p <0.01) of the composition of Example 1, and the composition of Example 1 and 2 ml / kg of the composition of Example 1, respectively, compared to the control group. The reduction effect of was observed. It was also more effective than the 6.25 ml / kg PC treated group, which showed 71% less acetaldehyde in blood than the control group.

Experimental Example 3 Measurement of Lipid Peroxide Content in Erythrocytes

Lipid peroxidation in plasma was quantitatively analyzed using TBARS (thiobarbuturic acid) using modified Yagi method. The plasma was washed with 0.083 NH ₂ SO ₄ and 1% phosphotungustric acid, then TBA reaction mixture (1% TBA: acetic acid: DW = 1: 1: 3) and 8.1% SDS were added, followed by vigorous stirring. After 1 hour of reaction in boiling water at 100 ℃ centrifuged. The supernatant was measured at a wavelength of 540 nm and compared and quantified by preparing a standard curve using 1,1,3,3, -tetraepoxy propane (TEP) as a standard. The results are published in Table 3 and FIG. 2 below. All results are expressed as mean ± standard error (SE).

TABLE 3

Control JBU (1 ml / kg) JBU (5 ml / kg) Liver TBARS (mmol / mg Protein) 5.20 ± 1.00 3.00 ± 0.35 1.20 ± 0.20

The blood oxidative damage was measured by the amount of lipid peroxide in erythrocytes at 3 hours after the blood alcohol concentration sufficiently increased after alcohol intake. Example 1 When using 1ml / kg compared to the control group, 42% was decreased and 2ml / kg was taken. In case of the use, it was decreased by 77%.

Experimental Example 4 GPT and GOT Measurement

In order to examine the protective effect of liver damage of the composition of the present invention divided into four groups, distilled water in the negative control group and the normal control group, the composition of Example 1 in the composition administration group of Example 1, the existing product in the positive control (PC) for 7 days Oral administration. After 3 hours of final administration of the drug, CCl ₄ diluted with olive oil was intraperitoneally administered at a dose of 0.45 ml / kg, and micro-vein blood was collected over time to measure serum GOT and GPT. GOT, GPT activity was measured using the kit for measuring GPT and GOT activity of Yeongdong Pharmaceutical Co., Ltd. using the Retiman-Franket method. The results are posted in Table 4 and FIG. 3 (GPT) and FIG. 4 (GOT). It was. All test results are expressed as mean ± standard error (SE). In addition, the liver tissue of rats to which CCl ₄ was administered was visually observed and fixed in 10% formalin solution. The fixed tissues were paraffin-embedded according to a conventional method, and tissue fragments were made by H & E staining and observed with an optical microscope. The photo is shown in FIG.

Table 4

Aid Dose (ml / kg, p.o.) GPT (KA unit / l) GOT (KA unit / l) Untreated - 10.9 ± 1.8 74.6 ± 4.2 CCl ₄ - 493.4 ± 56.6 412.7 ± 33.8 CCl ₄ + JBU 5.0 286.3 ± 63.1 296.9 ± 32.4 PC 6.25 374.9 ± 99.9 372.4 ± 37.6

Administration of carbon tetrachloride increased GPT levels by 45-fold and GOT levels by 5.5-fold. In the blood GPT level, the composition of the present invention showed a 42% reduction effect, which was superior to the positive control group (previous product) showing a 24% reduction effect. In addition, the composition of the present invention showed a 28% reduction in blood GOT levels, showing an excellent efficacy compared to the positive control group showed a 10% reduction.

Experimental Example 5 Clinical Trial Results for Acute Alcohol Hangover Improvement Efficacy

`20 healthy males over 20 years old were tested in two rounds.

Their characteristics are summarized in Table 5 below.

Table 5

  Age (years) 22.76 ± 6.07 Height (cm) 173.57 ± 8.91 Weight (Kg) 60.43 ± 8.22 BMI (Body Mass Index) (Kg / m2) 23.30 ± 3.22

Each of ten subjects randomly selected to take the composition and placebo of Example 1 of the present invention, but the order of taking was randomly determined. In addition, a 14-day washout period was applied to eliminate the carry over or residual effect of the first product taken. All subjects were allowed to fast after dinner the day before and the experiment was performed on an empty stomach around 9 am the next day. First of all, all subjects received intravenous blood samples, and 10 randomly selected subjects of 20 subjects received one dose (60 mL) of JBU and the other 10 subjects received the same volume of bottled water. After 15 minutes, 250 ml of soju and a small amount of snacks were given for 30 minutes. After ingestion, intravenous blood collection was performed 30 minutes and 2 hours, respectively, to measure blood alcohol concentration and acetaldehyde concentration. All test results are expressed as mean ± standard error (SE). For comparison of the test values between the control group and the composition treatment group of Example 1, a nonparametric test Wilcoxon signed rank test was used. Statistical significance was set when the p value was less than 0.05. The results are published in Tables 6 and 7, and FIGS. 6 and 7.

Table 6 Effect on Blood Alcohol Concentration

Alcohol (ppm) Control Example 1 P value 30 min 525.33 ± 22.16 410.96 ± 36.97 0.049 120 min 371.18 ± 30.82 309.72 ± 26.46 0.148

Blood alcohol concentration after 30 minutes of alcohol intake was 21.8% lower than the control group in the composition-treated group of the present invention, and 16.6% lower after 120 minutes. After 30 minutes of alcohol intake, the results were found to be statistically significant by Wilcoxon signed rank test.

Table 7 Effects on Acetaldehyde Concentrations in Blood

Acetaldehyde (ppm) Control JBU P value 30 min 3.72 ± 0.19 3.01 ± 0.31 0.098 120 min 2.51 ± 0.28 2.19 ± 0.31 0.501

Blood acetaldehyde concentration after 30 minutes of alcohol intake was 19.1% lower in the JBU group than in the control group and 12.7% after 120 minutes.

To assess subjective symptoms, a survey was conducted at 30 minutes, 2 hours, 5 hours, and 8 hours after alcohol consumption. The questionnaire has 18 questions, blurred judgment, fatigue, decreased memory, headache, heart palpitations, emotional anxiety, staggering, drowsiness, vomiting (disgust), lower abdominal discomfort, facial and skin flushing, visual impairment, hearing impairment, thirst, A total of 18 questions, including lethargy, nervousness, tremors, and pale face, were written in five scales of 0, 1, 2, 3, and 4.

After 14 days, the above procedure was repeated with different dosage formulations.

All test results are expressed as mean ± standard error (SE). For comparison of the test values between the control group and the composition treatment group of Example 1, a nonparametric test Wilcoxon signed rank test was used. Statistical significance was set when the p value was less than 0.05. The results are reported in Tables 8-12 below.

Table 8 Fatigue

Control JBU P value 30 min 1.00 ± 0.25 1.05 ± 0.23 0.725 2 h 0.94 ± 0.20 0.66 ± 0.19 0.096 5 h 1.27 ± 0.21 0.94 ± 0.22 0.058 8 h 0.77 ± 0.24 0.61 ± 0.20 0.558

After 30 minutes, 2 hours, 5 hours, and 8 hours of alcohol consumption, the questionnaire for “fatigue feeling” showed that the symptoms were reduced in the JBU-treated group compared to the control group for 2 hours, 5 hours, and 8 hours. In case of symptoms, the JBU group was found to have reduced symptoms.

Table 9 Headaches

Control JBU P value 30 min 0.33 ± 0.18 0.33 ± 0.16 1.000 2 h 0.38 ± 0.23 0.22 ± 0.10 0.705 5 h 0.77 ± 0.27 0.27 ± 0.10 0.053 8 h 0.44 ± 0.23 0.05 ± 0.05 0.059

After 30 minutes, 2 hours, 5 hours, and 8 hours of alcohol intake, the questionnaire for “headache” was found to be significantly decreased in the JBU group compared to the control group at 5 and 8 hours.

Table 10 Heart Beats

Control JBU P value 30 min 0.55 ± 0.20 0.22 ± 0.12 0.034 2 h 0.22 ± 0.12 0.05 ± 0.05 0.180 5 h 0.27 ± 0.10 0.05 ± 0.05 0.046 8 h 0.00 ± 0.00 0.00 ± 0.00 1.000

After 30 minutes, 2 hours, 5 hours, and 8 hours of alcohol consumption, the questionnaire for “heart palpitation” showed that the JBU group had smaller heartbeat symptoms than the control group. The symptoms were significantly weaker in the taking group and significantly lower even after 5 hours.

Table 11 Drowsiness

Control JBU P value 30 min 0.83 ± 0.23 0.88 ± 0.21 0.739 2 h 1.11 ± 0.22 0.66 ± 0.19 0.075 5 h 1.38 ± 0.231.0 (0.0,3.0) 1.05 ± 0.22 0.157 8 h 0.77 ± 0.23 0.55 ± 0.21 0.047

After 30 minutes, 2 hours, 5 hours, and 8 hours of alcohol consumption, the questionnaire about “drowsiness” showed that over time, the JBU group had less drowsiness than the control group. It was determined that there was a significant decrease in the group.

Table 12 Face, Skin Flush

Control JBU P value 30 min 1.22 ± 0.34a 0.83 ± 0.23 0.023b 2 h 0.5 ± 0.2 0.16 ± 0.09 0.096 5 h 0.33 ± 0.11 0.22 ± 0.1 0.317 8 h 0.00 ± 0.00 0.11 ± 0.07 0.157

After 30 minutes, 2 hours, 5 hours, and 8 hours of alcohol intake, the questionnaire for “face and skin flushing” showed a significant decrease in the JBU group compared to the control group at 30 minutes of alcohol consumption.

Table 12 Helplessness

Control JBU P value 30 min 0.88 ± 0.24 0.66 ± 0.18 0.206 2 h 0.72 ± 0.17 0.44 ± 0.18 0.132 5 h 0.66 ± 0.19 0.38 ± 0.14 0.059 8 h 0.38 ± 0.14 0.22 ± 0.10 0.366

After 30 minutes, 2 hours, 5 hours, and 8 hours of alcohol consumption, the questionnaire for “nervous feeling” showed that symptoms were alleviated in the JBU group compared to the control group, and significantly increased in the JBU group compared to the control group at 5 hours. It was found to decrease.

Experimental Example 6 Clinical Trial Results for Acute Alcohol Hangover Improvement Efficacy

Subjects were selected from volunteers among patients with chronic alcoholism. Patients with subjective symptoms and biochemical findings related to liver injury were included.

-Person whose GPT, GOT, GGT is over the normal range

Normal range (IU / L): GOT 0 to 37 GPT 0 to 40 GGT 7 to 50

     -25-50 years old among those who have general force, liver pain, anxiety, memory loss, dislike of food, nausea or vomiting, and dependence on alcohol (over 5 years) Males and females were excluded, but other impaired organs such as lungs and kidneys were excluded. For the administration, the same prescription was administered at the same dose without adding or subtracting symptoms for 40 days, and the administration method was to take 1 pack (30 ml) twice a day, morning and evening, prepared by the Korean Institute of Oriental Medicine. Fasted alcoholic foods. The number of subjects was 60, male and female (43), female (7), height (Mean ± SE) of 168.57 ± 7.67 and body weight (Mean ± SE) of 66.86 ± 7.43. 20 control subjects were given 4 tablets of 4 tablets twice a day in the morning and evening for 40 days. Hepatitis tablets were approved by the Jilin Provincial Office of Sanitary Medicine and provided by Yanbian Chosun Hospital. .

* Items to be evaluated before and during medication:

  ① GOT, GPT, GGT measurement: 2 times after dosing before dosing

  ② General Survey Findings: 2 times before the symptom survey and after the end of the administration

       Indication of symptom level 4 stages 無 (-) 0 point, 輕 (+) 1 point, 中 (++) 2 point, 重 (+++) 3 point

* Determination of treatment effect (Effectiveness Criteria): GOT, GPT value decrease

  ① If the value returns to normal: normal

  ② If the number decreases but does not return to normal: improvement

  ③ If there is no change or increased value: invalid

  ④ Cure Rate (%): (normal + improvement) / total × 100

The experimental results are shown below.

1) JBU administration group

Table 13 Paperweight Results

Before taking After taking P value Telegraph 2.60 ± 0.09a 0.04 ± 0.02 <0.001c Liver pain 0.76 ± 0.13 0.04 ± 0.02 <0.001 Fuchang 1.74 ± 0.11 0.08 ± 0.03 <0.001 Loss of appetite 1.56 ± 0.09 0.04 ± 0.02 <0.001 miscarriage of justice 0.74 ± 0.14 0.00 ± 0.00 <0.001 Alcohol dependence 0.86 ± 0.10 0.04 ± 0.02 <0.001 Memory loss 1.44 ± 0.10 0.58 ± 0.09 <0.001 Anxiety 0.14 ± 0.04 0.02 ± 0.02 0.014

Table 14 GOT, GPT, GGT Changes

After taking normal Improving invalidity Treatment rate GOT (0 ~ 37) 25 22 3 94% GPT (0 ~ 40) 25 20 5 90% GGT (7-50) 23 24 3 94%

Normal: If you show normal range after taking

Improvement: The level decreased after taking but not in the normal range.

Invalid: No change in the level or increase after taking

Treatment rate (%): normal + improvement / total × 100

Table 15

n = 50 Before taking After taking (40 days) Change P value b GOT (0 ~ 37) 83.96 ± 6.85a 49.74 ± 5.49 -34.64 ± 4.07 <0.001 GPT (0 ~ 40) 87.08 ± 4.46 52.44 ± 3.95 -34.22 ± 4.67 <0.001 GGT (7-50) 140.20 ± 16.38 74.72 ± 8.26 -65.48 ± 12.15 <0.001

2) control group (liver)

Table 15 GOT, GPT, GGT Changes

After taking normal Improving invalidity Treatment rate GOT (0 ~ 37) 11 7 2 90% GPT (0 ~ 40) 12 6 2 90% GGT (7-50) 16 2 2 90%

Normal: If you show normal range after taking

Improvement: The level decreased after taking but not in the normal range.

Invalid: No change in the level or increase after taking

Treatment rate (%): normal + improvement / total × 100

Table 16

n = 20 Before taking After taking (40 days) Change P value b GOT (0 ~ 37) 54.8 ± 2.90a 42.05 ± 3.07 -12.75 ± 2.66 0.005 GPT (0 ~ 40) 70.65 ± 5.46 48.85 ± 5.74 -21.80 ± 3.93 0.006 GGT (7-50) 89.65 ± 7.82 44.40 ± 5.32 -45.25 ± 9.01 0.000

3) Comparison of changes in GOT, GPT, GTG between JBU and liver bio-administration groups

Table 17

JBU Liver liver P value 3) GOT variation 1) -34.22 ± 4.672) -12.75 ± 2.66 <0.001 ** GPT variation -34.64 ± 4.07 -21.80 ± 3.93 0.027 * GGT variation -65.48 ± 12.15 -45.25 ± 9.01 0.186

As a result of comparing the changes of GOT, GPT, GGT in the composition of the present invention and the liver bio-administration group, the composition (JBU) of the present invention was found to have a greater decrease in the number of GOT, GPT, GGT, compared to the liver biopsy, GOT, GPT Was statistically significant at, and GGT was not statistically significant. JBU is shown to have better liver function than liver liver.

Hangover composition of the present invention significantly reduced blood alcohol concentration 30 minutes after alcohol intake and showed a tendency to decrease the blood acetaldehyde concentration. In addition, the symptoms of headache, heart palpitations, emotional anxiety, fatigue, nausea, drowsiness, lower abdominal discomfort, thirst, and lethargy were alleviated compared to the control group.

As a result of subjective symptoms and biochemical findings related to liver damage among volunteers with chronic alcoholism, 50 patients with abnormal GPT, GOT, and GGT were selected. At the same dose, GOT, GPT and GGT were measured before and after dosing and symptom questionnaire was administered twice before and after dosing. Systemic force, liver pain, abdominal pain, anorexia, nausea, alcohol dependence, Symptoms of memory loss and anxiety were all statistically significant and GOT, GPT and GGT levels were also statistically significant. When hepatitis treatment was approved by the China Sanitary Authority as a control group, it showed statistically superior efficacy.

1 is a graph showing the effect of the composition of the present invention on blood alcohol concentration in rats after alcohol treatment

Figure 2 is a graph showing the effect of the composition of the present invention on lipid peroxides in red blood cells of rats after alcohol treatment.

Figure 3 is a graph showing the effect of the composition of the present invention on GTP activity in rats treated with carbon tetrachloride.

Figure 4 is a graph showing the effect of the composition of the present invention on GOP activity in carbon tetrachloride treated rats.

Fig. 5 shows micrographs of livers of rats after 24 hours of carbon tetrachloride injection (A) CCl4 untreated group, (B) CCl4 group (C) Composition + CCl4 group of Example 1, (D) PC + CCl4 group.

6 is a graph showing the effect of the composition of the present invention on the blood alcohol concentration after drinking in the human body

7 is a graph showing the effect of the composition of the present invention on the concentration of acetaldehyde in blood after drinking in the human body

Claims (5)

Artemisia capillaris , Pueraria thunbergiana , Hovenia dulcis , Silybum maxianum , Artractylodes macrocephala , Polyporus umbellatus , Poria cocos , and dermis Hangover composition comprising Citrus unshiu ), red ginseng ( Panax schinseng ) and Gojija ( Lycium chinense ). The method according to claim 1, wherein Jinjin, browning, earth, baekchul, yeongryok, bokyeong, dermis, goji berries are used in dry weight ratio of 1-10 parts by weight, respectively, the vesicle system is Jinjin, browning, earth, baekchul, ghost, ghost, 100-300 mg per 30 ml of extracted extract of hot water by mixing dermis and goji berry, red ginseng concentrate 0.25-1% (v / v) composition for hangover relief. Injin, Galhwa, Earthling, Baekchul, Seolyeong, Bokryeong, Dermis, and Goji are mixed and extracted by hot water at 80-100 ℃ for over 16 hours in the extraction tank, then concentrated by vacuum at 50-70 ℃. A method for producing a composition for relieving hangover or improving liver function, characterized in that the mixture is added with a concentrate and a defense system. Artemisia capillaris , Pueraria thunbergiana , Hovenia dulcis , Silybum maxianum , Artractylodes macrocephala , Polyporus umbellatus , Poria cocos , and dermis Citrus unshiu ), red ginseng ( Panax schinseng ) and gojija ( Lycium chinense ) composition for improving liver function. The method according to claim 4, wherein the phosphorus, browning, earth, baekchul, ghost, bokyeong, dermis, goji berries are used in dry weight ratio of 1 to 10 parts by weight, respectively, the vesicle system is jinjin, browning, earth, baekchul, ghost, ghost, 100-300 mg, 30 g of red ginseng extract per 30 ml of the extract extracted by hot water by mixing the dermis and goji berry, the composition for improving liver function, comprising 0.25-1% (v / v).