KR20040108553A - 녹색 형광 단백질과 Bfl-1의 융합단백질 또는 이를코딩하는 유전자를 포함하는 세포사멸을 유도하기 위한약학 조성물 - Google Patents
녹색 형광 단백질과 Bfl-1의 융합단백질 또는 이를코딩하는 유전자를 포함하는 세포사멸을 유도하기 위한약학 조성물 Download PDFInfo
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- KR20040108553A KR20040108553A KR1020040034598A KR20040034598A KR20040108553A KR 20040108553 A KR20040108553 A KR 20040108553A KR 1020040034598 A KR1020040034598 A KR 1020040034598A KR 20040034598 A KR20040034598 A KR 20040034598A KR 20040108553 A KR20040108553 A KR 20040108553A
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- South Korea
- Prior art keywords
- bfl
- gfp
- leu
- gly
- lys
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
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- 230000007017 scission Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
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Classifications
-
- E—FIXED CONSTRUCTIONS
- E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
- E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
- E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
- E06B9/56—Operating, guiding or securing devices or arrangements for roll-type closures; Spring drums; Tape drums; Counterweighting arrangements therefor
- E06B9/58—Guiding devices
- E06B9/581—Means to prevent or induce disengagement of shutter from side rails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- E—FIXED CONSTRUCTIONS
- E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
- E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
- E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
- E06B9/02—Shutters, movable grilles, or other safety closing devices, e.g. against burglary
- E06B9/08—Roll-type closures
- E06B9/11—Roller shutters
- E06B9/17—Parts or details of roller shutters, e.g. suspension devices, shutter boxes, wicket doors, ventilation openings
- E06B9/17076—Sealing or antirattling arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
-
- E—FIXED CONSTRUCTIONS
- E05—LOCKS; KEYS; WINDOW OR DOOR FITTINGS; SAFES
- E05Y—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES E05D AND E05F, RELATING TO CONSTRUCTION ELEMENTS, ELECTRIC CONTROL, POWER SUPPLY, POWER SIGNAL OR TRANSMISSION, USER INTERFACES, MOUNTING OR COUPLING, DETAILS, ACCESSORIES, AUXILIARY OPERATIONS NOT OTHERWISE PROVIDED FOR, APPLICATION THEREOF
- E05Y2800/00—Details, accessories and auxiliary operations not otherwise provided for
- E05Y2800/40—Physical or chemical protection
- E05Y2800/422—Physical or chemical protection against vibration or noise
-
- E—FIXED CONSTRUCTIONS
- E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
- E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
- E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
- E06B9/02—Shutters, movable grilles, or other safety closing devices, e.g. against burglary
- E06B9/08—Roll-type closures
- E06B9/11—Roller shutters
- E06B9/17—Parts or details of roller shutters, e.g. suspension devices, shutter boxes, wicket doors, ventilation openings
- E06B2009/17038—Shutter cleaning arrangements
-
- E—FIXED CONSTRUCTIONS
- E06—DOORS, WINDOWS, SHUTTERS, OR ROLLER BLINDS IN GENERAL; LADDERS
- E06B—FIXED OR MOVABLE CLOSURES FOR OPENINGS IN BUILDINGS, VEHICLES, FENCES OR LIKE ENCLOSURES IN GENERAL, e.g. DOORS, WINDOWS, BLINDS, GATES
- E06B9/00—Screening or protective devices for wall or similar openings, with or without operating or securing mechanisms; Closures of similar construction
- E06B9/56—Operating, guiding or securing devices or arrangements for roll-type closures; Spring drums; Tape drums; Counterweighting arrangements therefor
- E06B9/58—Guiding devices
- E06B2009/588—Sealings for guides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Structural Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Architecture (AREA)
- Marine Sciences & Fisheries (AREA)
- Civil Engineering (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (6)
- 서열번호: 2의 Bfl-1 단백질 또는 서열번호: 2의 147 내지 175번 아미노산을 포함하는 Bfl-1 단백질의 단편에 녹색 형광 단백질 (green fluorescent protein, GFP)이 융합된 융합단백질 또는 이를 코딩하는 유전자 및 약학적으로 허용가능한 담체를 포함하는, 세포사멸을 유도하기 위한 약학 조성물.
- 제 1항에 있어서,녹색 형광 단백질이 Bfl-1 단백질 또는 그의 단편의 N-말단에 융합되는 것을 특징으로 하는 조성물.
- 제 1항에 있어서,Bfl-1 단백질의 단편이서열번호: 2의 62번 내지 175번 아미노산;서열번호: 2의 98번 내지 175번 아미노산; 및서열번호: 2의 147번 내지 175번 아미노산으로 이루어진 폴리펩티드들로 구성된 군으로부터 선택되는 것을 특징으로 하는 조성물.
- 제 1항에 있어서,융합단백질이서열번호: 27내지30으로 기재되는 아미노산 서열을 갖는 폴리펩티드들로 구성된 군으로부터 선택되는 것을 특징으로 하는 조성물.
- 제 1항에 있어서,유전자가서열번호: 23내지26으로 기재되는 염기서열을 갖는 것을 폴리뉴클레오티드들로부터 선택되는 것을 특징으로 하는 조성물.
- 제 1항에 있어서,암 또는 세포 증식증을 치료하기 위해 사용되는 것을 특징으로 하는 조성물.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020030038670 | 2003-06-16 | ||
KR20030038670 | 2003-06-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040108553A true KR20040108553A (ko) | 2004-12-24 |
KR100577512B1 KR100577512B1 (ko) | 2006-05-10 |
Family
ID=33550168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020040034598A KR100577512B1 (ko) | 2003-06-16 | 2004-05-17 | 녹색 형광 단백질과 Bfl-1의 융합단백질 또는 이를코딩하는 유전자를 포함하는 세포사멸을 유도하기 위한약학 조성물 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20070066518A1 (ko) |
EP (1) | EP1633386A1 (ko) |
KR (1) | KR100577512B1 (ko) |
WO (1) | WO2004110474A1 (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105061580B (zh) * | 2006-10-03 | 2020-06-05 | 罗格斯新泽西州立大学 | 多肽和药物组合物及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR960034413A (ko) * | 1995-03-24 | 1996-10-22 | 권계홍 | 아폽토시스 조절 유전자 |
US5874304A (en) * | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
-
2004
- 2004-05-17 KR KR1020040034598A patent/KR100577512B1/ko active IP Right Grant
- 2004-06-03 WO PCT/KR2004/001324 patent/WO2004110474A1/en active Application Filing
- 2004-06-03 US US10/558,296 patent/US20070066518A1/en not_active Abandoned
- 2004-06-03 EP EP04736014A patent/EP1633386A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1633386A1 (en) | 2006-03-15 |
WO2004110474A1 (en) | 2004-12-23 |
US20070066518A1 (en) | 2007-03-22 |
KR100577512B1 (ko) | 2006-05-10 |
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