KR20040094756A - 신경 포착 증후군의 치료 방법 - Google Patents
신경 포착 증후군의 치료 방법 Download PDFInfo
- Publication number
- KR20040094756A KR20040094756A KR10-2004-7013635A KR20047013635A KR20040094756A KR 20040094756 A KR20040094756 A KR 20040094756A KR 20047013635 A KR20047013635 A KR 20047013635A KR 20040094756 A KR20040094756 A KR 20040094756A
- Authority
- KR
- South Korea
- Prior art keywords
- nerve
- syndrome
- pain
- botulinum toxin
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract description 25
- 208000011580 syndromic disease Diseases 0.000 title claims abstract description 22
- 208000019382 nerve compression syndrome Diseases 0.000 title description 2
- 208000002193 Pain Diseases 0.000 claims abstract description 32
- 210000005036 nerve Anatomy 0.000 claims abstract description 24
- 108030001720 Bontoxilysin Proteins 0.000 claims abstract description 20
- 229940053031 botulinum toxin Drugs 0.000 claims abstract description 20
- 210000002808 connective tissue Anatomy 0.000 claims abstract description 3
- 210000003205 muscle Anatomy 0.000 claims description 25
- 238000011282 treatment Methods 0.000 claims description 19
- 230000006835 compression Effects 0.000 claims description 12
- 238000007906 compression Methods 0.000 claims description 12
- 231100000765 toxin Toxicity 0.000 claims description 9
- 239000003053 toxin Substances 0.000 claims description 9
- 238000002347 injection Methods 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 8
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims description 5
- 208000008713 Piriformis Muscle Syndrome Diseases 0.000 claims description 3
- 206010049433 piriformis syndrome Diseases 0.000 claims description 3
- 208000009873 radial neuropathy Diseases 0.000 claims description 3
- 206010071930 Radial nerve compression Diseases 0.000 claims description 2
- 208000009347 Cubital Tunnel Syndrome Diseases 0.000 claims 1
- 230000001037 epileptic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 description 16
- 210000000707 wrist Anatomy 0.000 description 10
- 210000003497 sciatic nerve Anatomy 0.000 description 9
- 238000002560 therapeutic procedure Methods 0.000 description 9
- 206010048627 thoracic outlet syndrome Diseases 0.000 description 8
- 208000004044 Hypesthesia Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 208000034783 hypoesthesia Diseases 0.000 description 7
- 231100000862 numbness Toxicity 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 210000003811 finger Anatomy 0.000 description 6
- 208000035824 paresthesia Diseases 0.000 description 6
- 206010029174 Nerve compression Diseases 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 210000002414 leg Anatomy 0.000 description 5
- 238000002595 magnetic resonance imaging Methods 0.000 description 5
- 239000000902 placebo Substances 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 5
- 230000002159 abnormal effect Effects 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 210000004247 hand Anatomy 0.000 description 4
- 210000003127 knee Anatomy 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 210000001617 median nerve Anatomy 0.000 description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010033799 Paralysis Diseases 0.000 description 3
- 208000030193 Tinel sign Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 210000003461 brachial plexus Anatomy 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- 230000006735 deficit Effects 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000002567 electromyography Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000007830 nerve conduction Effects 0.000 description 3
- 210000000578 peripheral nerve Anatomy 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 210000002979 radial nerve Anatomy 0.000 description 3
- 108010074523 rimabotulinumtoxinB Proteins 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 210000003813 thumb Anatomy 0.000 description 3
- 210000000658 ulnar nerve Anatomy 0.000 description 3
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 2
- 208000014094 Dystonic disease Diseases 0.000 description 2
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 2
- 229960004373 acetylcholine Drugs 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 208000010118 dystonia Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 230000003518 presynaptic effect Effects 0.000 description 2
- 235000008160 pyridoxine Nutrition 0.000 description 2
- 239000011677 pyridoxine Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 229940011671 vitamin b6 Drugs 0.000 description 2
- 206010000599 Acromegaly Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000018084 Bone neoplasm Diseases 0.000 description 1
- 206010006811 Bursitis Diseases 0.000 description 1
- 108010009685 Cholinergic Receptors Proteins 0.000 description 1
- 241000193155 Clostridium botulinum Species 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 201000011275 Epicondylitis Diseases 0.000 description 1
- 206010063006 Facial spasm Diseases 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
- 206010024612 Lipoma Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 208000012322 Raynaud phenomenon Diseases 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010040030 Sensory loss Diseases 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 208000004350 Strabismus Diseases 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 208000002240 Tennis Elbow Diseases 0.000 description 1
- 206010044074 Torticollis Diseases 0.000 description 1
- 102000034337 acetylcholine receptors Human genes 0.000 description 1
- 206010002022 amyloidosis Diseases 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 231100001103 botulinum neurotoxin Toxicity 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 201000002866 cervical dystonia Diseases 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 210000003109 clavicle Anatomy 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 238000013170 computed tomography imaging Methods 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000002920 convulsive effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 208000024764 elbow pain Diseases 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 230000028023 exocytosis Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000001097 facial muscle Anatomy 0.000 description 1
- 208000003532 hypothyroidism Diseases 0.000 description 1
- 230000002989 hypothyroidism Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004932 little finger Anatomy 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 230000036640 muscle relaxation Effects 0.000 description 1
- 229940112646 myobloc Drugs 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000007971 neurological deficit Effects 0.000 description 1
- 208000018360 neuromuscular disease Diseases 0.000 description 1
- 210000000715 neuromuscular junction Anatomy 0.000 description 1
- 239000002581 neurotoxin Substances 0.000 description 1
- 231100000618 neurotoxin Toxicity 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000001144 postural effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 208000012788 shakes Diseases 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000003270 subclavian artery Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000000623 ulna Anatomy 0.000 description 1
- 208000036722 ulnar neuropathy Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36062802P | 2002-03-01 | 2002-03-01 | |
| US60/360,628 | 2002-03-01 | ||
| PCT/US2003/006233 WO2003073994A2 (en) | 2002-03-01 | 2003-02-27 | Methods of treating nerve entrapment syndromes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20040094756A true KR20040094756A (ko) | 2004-11-10 |
Family
ID=27788996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR10-2004-7013635A Ceased KR20040094756A (ko) | 2002-03-01 | 2003-02-27 | 신경 포착 증후군의 치료 방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20030224019A1 (https=) |
| EP (1) | EP1487481A4 (https=) |
| JP (1) | JP2005524663A (https=) |
| KR (1) | KR20040094756A (https=) |
| AU (2) | AU2003212473A1 (https=) |
| CA (1) | CA2477808A1 (https=) |
| WO (1) | WO2003073994A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7838008B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
| KR20040094756A (ko) * | 2002-03-01 | 2004-11-10 | 엘란 파마슈티칼스, 인크. | 신경 포착 증후군의 치료 방법 |
| US7300412B2 (en) * | 2002-05-10 | 2007-11-27 | Hospital For Joint Diseases | Methods for therapeutic treatment of carpal tunnel syndrome |
| US8734810B2 (en) * | 2003-10-29 | 2014-05-27 | Allergan, Inc. | Botulinum toxin treatments of neurological and neuropsychiatric disorders |
| US8871224B2 (en) * | 2003-12-09 | 2014-10-28 | Allergan, Inc. | Botulinum toxin therapy for skin disorders |
| US9078892B2 (en) * | 2004-02-26 | 2015-07-14 | Allergan, Inc. | Methods for treating pain and for treating a medication overuse disorder |
| US20100266638A1 (en) * | 2004-02-26 | 2010-10-21 | Allergan, Inc. | Headache treatment method |
| US20050191321A1 (en) * | 2004-02-26 | 2005-09-01 | Allergan, Inc. | Methods for treating headache |
| US20050220821A1 (en) * | 2004-03-31 | 2005-10-06 | Allergan, Inc. | Pressure sore treatment |
| US20050220734A1 (en) * | 2004-04-02 | 2005-10-06 | Allergan, Inc. | Therapy for melanin related afflictions |
| KR100668570B1 (ko) * | 2004-06-28 | 2007-01-16 | 입센 리미티드 | 복재신경 포착에 의한 무릎 관절 통증 치료를 위한,보툴리눔 독소를 포함하는 제약 조성물 |
| US6991789B2 (en) * | 2004-06-29 | 2006-01-31 | Allergas, Inc. | Methods of modulating intracellular degradation rates of toxins |
| US20060024331A1 (en) * | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
| US7179474B2 (en) * | 2004-09-03 | 2007-02-20 | Allergan, Inc. | Methods for treating a buttock deformity |
| US7429386B2 (en) * | 2004-09-03 | 2008-09-30 | Allergan, Inc. | Stretch mark treatment |
| US7897147B2 (en) | 2004-10-20 | 2011-03-01 | Allergan, Inc. | Treatment of premenstrual disorders |
| US7749515B2 (en) * | 2005-02-01 | 2010-07-06 | Allergan, Inc. | Targeted delivery of botulinum toxin to the sphenopalatine ganglion |
| US7655244B2 (en) | 2005-02-01 | 2010-02-02 | Allergan, Inc. | Targeted delivery of botulinum toxin for the treatment and prevention of trigeminal autonomic cephalgias, migraine and vascular conditions |
| US7419675B2 (en) * | 2005-05-26 | 2008-09-02 | Allergan, Inc. | Method for treating peritoneal adhesions |
| US7824694B2 (en) * | 2006-01-12 | 2010-11-02 | Allergan, Inc. | Methods for enhancing therapeutic effects of a neurotoxin |
| US20070178121A1 (en) * | 2006-01-27 | 2007-08-02 | Allergan, Inc. | Methods for enhancing skin treatments |
| CN101074935B (zh) * | 2006-05-19 | 2011-03-23 | 清华大学 | 探测器阵列及设备 |
| US9061025B2 (en) * | 2006-08-31 | 2015-06-23 | Allergan, Inc. | Methods for selecting headache patients responsive to botulinum toxin therapy |
| US8617571B2 (en) * | 2008-04-03 | 2013-12-31 | Allergan, Inc. | Suture line administration technique using botulinum toxin |
| US20100028385A1 (en) * | 2008-08-04 | 2010-02-04 | Allergan, Inc. | Treatment of excess cerumen secretion |
| WO2011038015A1 (en) | 2009-09-24 | 2011-03-31 | Allergan, Inc. | Method of treating osteoporosis with a neurotoxin |
| US9238324B2 (en) | 2010-03-31 | 2016-01-19 | Toray Plastics (Amercia), Inc. | Biaxially oriented polylactic acid film with reduced noise level |
| US9101794B2 (en) | 2010-09-19 | 2015-08-11 | Thomas Alan Ferguson, JR. | Piri-stretcher |
| US9782617B2 (en) | 2010-09-19 | 2017-10-10 | Thomas Alan Ferguson, JR. | Piri-stretcher system |
| USD703824S1 (en) | 2010-09-19 | 2014-04-29 | Thomas Alan Ferguson, JR. | Leg stretching device |
| US8697090B2 (en) | 2011-05-05 | 2014-04-15 | Allergan, Inc. | Method of treating persistent genital arousal disorder with a neurotoxin |
| EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
| EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
| EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
| EP2836193B1 (en) | 2012-04-13 | 2018-01-31 | Lubrizol Advanced Materials, Inc. | Compounds which inhibit neuronal exocytosis (ii) |
| WO2018038301A1 (en) | 2016-08-26 | 2018-03-01 | Hugel Inc. | Stabilized liquid formulation of botulinum toxin and preparation method thereof |
| EP3470054B1 (en) | 2017-10-11 | 2023-09-20 | Hugel Inc. | Microstructure formulation techniques for botulinum toxin |
| US10525111B2 (en) | 2017-10-12 | 2020-01-07 | Hugel, Inc. | Microstructure formulation techniques for botulinum toxin |
| US10792400B2 (en) | 2017-10-12 | 2020-10-06 | Hugel Inc. | Microstructure formulation techniques for botulinum toxin |
| US10561715B2 (en) * | 2018-02-26 | 2020-02-18 | Philip Andrew RADOVIC | Plantar heel pain syndrome treatment |
| LT3660509T (lt) | 2018-11-29 | 2022-05-10 | Hugel Inc. | Ląstelių panaudojimu paremtas būdas botulino toksino aktyvumui nustatyti |
| CN119258202A (zh) | 2023-07-05 | 2025-01-07 | 重庆誉颜制药有限公司 | 一种肉毒毒素蛋白组合物及其应用 |
| US12290301B1 (en) | 2024-08-19 | 2025-05-06 | Panacea Spine, LLC | Percutaneous surgical treatment for piriformis syndrome |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4932936A (en) * | 1988-01-29 | 1990-06-12 | Regents Of The University Of Minnesota | Method and device for pharmacological control of spasticity |
| US5053005A (en) * | 1989-04-21 | 1991-10-01 | Gary E. Borodic | Chemomodulation of curvature of the juvenile spine |
| US5183462A (en) * | 1990-08-21 | 1993-02-02 | Associated Synapse Biologics | Controlled administration of chemodenervating pharmaceuticals |
| CA2138020C (en) * | 1992-06-23 | 1999-02-16 | Eric A. Johnson | Pharmaceutical composition containing botulinum b complex |
| US5437291A (en) * | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
| US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
| PT1086702E (pt) * | 1994-05-09 | 2005-08-31 | William J Binder | Neurotoxinas pre-sinapticas para tratamento da dor de cabeca devida a enxaqueca |
| US5512547A (en) * | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
| US5562899A (en) * | 1995-02-28 | 1996-10-08 | Gerber; Allen | Medical prevention of lacerations to the vagina and perineum |
| US5721215A (en) * | 1996-03-20 | 1998-02-24 | Allergan | Injectable therapy for control of muscle spasms and pain related to muscle spasms |
| US6063768A (en) * | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
| US6113915A (en) * | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
| US6139845A (en) * | 1999-12-07 | 2000-10-31 | Allergan Sales, Inc. | Method for treating cancer with a neurotoxin |
| US6358513B1 (en) * | 2000-02-15 | 2002-03-19 | Allergan Sales, Inc. | Method for treating Hashimoto's thyroiditis |
| CA2369810C (en) * | 2002-01-30 | 2007-08-07 | 1474791 Ontario Limited | Method of treating pain |
| KR20040094756A (ko) * | 2002-03-01 | 2004-11-10 | 엘란 파마슈티칼스, 인크. | 신경 포착 증후군의 치료 방법 |
-
2003
- 2003-02-27 KR KR10-2004-7013635A patent/KR20040094756A/ko not_active Ceased
- 2003-02-27 EP EP03709413A patent/EP1487481A4/en not_active Withdrawn
- 2003-02-27 US US10/378,042 patent/US20030224019A1/en not_active Abandoned
- 2003-02-27 CA CA002477808A patent/CA2477808A1/en not_active Abandoned
- 2003-02-27 WO PCT/US2003/006233 patent/WO2003073994A2/en not_active Ceased
- 2003-02-27 AU AU2003212473A patent/AU2003212473A1/en not_active Abandoned
- 2003-02-27 JP JP2003572516A patent/JP2005524663A/ja active Pending
-
2008
- 2008-03-26 US US12/056,096 patent/US20080171065A1/en not_active Abandoned
-
2009
- 2009-05-01 AU AU2009201770A patent/AU2009201770A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1487481A4 (en) | 2005-11-23 |
| WO2003073994A3 (en) | 2004-02-05 |
| US20030224019A1 (en) | 2003-12-04 |
| EP1487481A2 (en) | 2004-12-22 |
| JP2005524663A (ja) | 2005-08-18 |
| WO2003073994A2 (en) | 2003-09-12 |
| AU2003212473A1 (en) | 2003-09-16 |
| AU2009201770A1 (en) | 2009-05-28 |
| US20080171065A1 (en) | 2008-07-17 |
| CA2477808A1 (en) | 2003-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20040094756A (ko) | 신경 포착 증후군의 치료 방법 | |
| Sölveborn | Radial epicondylalgia (‘tennis elbow'): treatment with stretching or forearm band. A prospective study with long‐term follow‐up including range‐of‐motion measurements | |
| Yelnik et al. | Drug treatments for spasticity | |
| Hsu et al. | Arthroscopic distension in the management of frozen shoulder | |
| JP4381477B2 (ja) | 筋膜疼痛症候群の治療方法 | |
| Lam et al. | Ultrasound and electrical stimulator-guided obturator nerve block with phenol in the treatment of hip adductor spasticity in long-term care patients: a randomized, triple blind, placebo controlled study | |
| Jozefczyk | The management of focal spasticity | |
| Reveille | Soft-tissue rheumatism: diagnosis and treatment | |
| Herzog et al. | A case report illustrating the combined use of cryoneurolysis and percutaneous needle tenotomy in the treatment of longstanding spastic shoulder contractures after stroke | |
| Ashour et al. | A comparison of the results of platelet-rich plasma injection versus the results of corticosteroid injections in de-quervain tenosynovitis | |
| Aswathy et al. | An effective Ayurveda management of Sarvangavata WSR to Guillain–Barre syndrome: A case report | |
| Tafler et al. | The function of osteopathic medicine in the treatment of adhesive capsulitis | |
| Check et al. | Sympathomimetic amine therapy found effective for treatment of refractory chronic complex regional pain syndrome (reflex sympathetic dystrophy) | |
| Koh et al. | Alcohol motor blocks: case series and a narrative review | |
| Peris et al. | Uses and technique of ultrasound-guided botulinum toxin infiltration | |
| Gadkari et al. | Review on Carpal Tunnel Syndrome | |
| Yildizgoren et al. | Carpal Tunnel Syndrome Resulting From Persistent Median Artery and Bifid Median Nerve: The Critical Role of Ultrasonography | |
| Ozbayrak et al. | Is there an additional benefit of ultrasound-guided coracohumeral ligament hydrorelease in cases with primary adhesive capsulitis undergoing ultrasound-guided shoulder hydrodilatation? | |
| Wilhelm et al. | 20 Upper Limb Spasticity With Botulinum Neurotoxin | |
| Kamruzzaman et al. | The Effect of Phonophoresis and Therapeutic Exercise in the Treatment of Adhesive Capsulitis | |
| Sarwar et al. | Efficacy of Spencer Technique and Scapular Mobilization in the Management of Adhesive Capsulitis: A Narrative Review: Spencer Technique and Scapular Mobilization for Adhesive Capsulitis | |
| Bursa et al. | Large and Intermediate Joint Injections | |
| Svir | Outpatient Physical Therapy Rehabilitation for a Patient with Wrist Pathology | |
| Zhu | Clinical observation on carpal joint sprain by puncturing Juliao (GB 29) | |
| IMAM et al. | A systematic review on frozen shoulder (adhesive capsulitis) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20040901 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
Patent event date: 20070122 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
|
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20080226 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20100121 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20100514 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20100121 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |