JP2005524663A - 神経エントラップメント症候群の処置方法 - Google Patents
神経エントラップメント症候群の処置方法 Download PDFInfo
- Publication number
- JP2005524663A JP2005524663A JP2003572516A JP2003572516A JP2005524663A JP 2005524663 A JP2005524663 A JP 2005524663A JP 2003572516 A JP2003572516 A JP 2003572516A JP 2003572516 A JP2003572516 A JP 2003572516A JP 2005524663 A JP2005524663 A JP 2005524663A
- Authority
- JP
- Japan
- Prior art keywords
- syndrome
- nerve
- pain
- botulinum toxin
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
手首の手根管を通る正中神経の圧迫
症状としては、ちくちくする痛みおよびしびれに関係した手及び手首の痛みがあり、標準的には正中神経に沿って分布するが(親指、人差し指および中指の手のひら側、薬指の半径の半分)、手全体に及ぶこともある。一般的に、患者は焼けるような痛み、疼痛、しびれ、ちくちくする痛みにより夜に目が覚め、感覚を軽減し、回復させるために手を振ることとなる。
処置としては、特に夜間における軽量の手首副子;例えば50mgのピリドキシン(ビタミンB6)の処方;および穏和な鎮痛薬(例えば、アセトアミノフェン、非ステロイド抗炎症剤)がある。幾人かは、コンピューターキーボードの位置を変えることや、他の人間工学的な矯正を行うことにより、軽減される。これらの手段では症状を制御できない場合には、ちょうど尺骨から掌側長腱にかけて、および、手首のしわの近位から遠位にかけて、コルチコステロイドを手根管に局所注射する。やっかいな症状が続き、若しくは繰り返される場合、または、手の弱りや母指球のやせが進行する場合は、切開や内視鏡を用いた手根管の外科的な圧迫除去が推奨される。
肘の尺骨神経の圧迫で、薬指と小指のしびれおよび感覚異常を引き起こす。
前腕近位または上腕背部の橈骨神経の浅枝の圧迫で、前腕及び手の背部に刺すような痛みを引き起こす。
慢性の不快な痛み、疼痛、ちくちくする痛み、またはしびれが臀部から始まり、坐骨神経の経路に沿って広がり、大腿骨と脛骨の背部全体を下り、脛骨の前部に至る。痛みは通常慢性的で、梨状筋が坐骨神経に対して圧迫されるとひどくなる(例えば、トイレ、車の座席、狭い自転車の椅子に座っている間や、走っている間)。梨状筋の痛みとは違い、坐骨神経のディスク圧迫は、通常腰痛、特に腰を伸ばすときの腰痛に、関係する。
徹底した身体的検査が、診断の基本である。フライバーグ操作(伸ばした大腿の激しい内側への回転)は、梨状筋を伸ばし、痛みを生じる。ペース操作(影響を受けた脚の外転)は、座っている患者において痛みを顕在化させる。ビーティ操作では、影響を受けていない脚側でテーブルに横になる。影響を受けている脚は、テーブル上で膝から曲げられた影響を受けていない脚の後ろに置かれる。テーブルから数インチ膝を起こすと、臀部に痛みを生じる。マーキンテスト(Mirkin test)では、患者は立って、膝をまっすぐにし、床に向かってゆっくりと曲げる。試験者は、坐骨神経が梨状筋と交差する臀部を圧迫し、接触箇所から始まり、脚の背部に広がる痛みを生ずる。痛みは、骨盤または直腸検査においても生じうる。
手、首、肩、または上腕の痛みおよび感覚麻痺の症状を特徴とする症候群
Claims (7)
- 治療に有効量のB型ボツリヌス毒素を患者に投与することにより、処置を必要とする患者の神経エントラップメント症候群を処置する方法。
- 治療に有効量のB型ボツリヌス毒素を患者に投与することにより、処置を必要とする患者の神経エントラップメント症候群による痛みを減らす方法。
- 毒素が、針を通じた注射により投与される、請求項1または2に記載の方法。
- 圧迫症候群が、梨状筋症候群、手根管症候群、肘部管症候群、および橈骨管症候群からなる群より選択される、請求項1または2に記載の方法。
- 注射が、圧迫された神経に接する筋組織に対して行われる、請求項3に記載の方法。
- 注射が、圧迫された神経のまわりの間質領域に対して行われる、請求項3に記載の方法。
- 注射が、圧迫された神経を囲む結合組織に対して行われる、請求項3に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36062802P | 2002-03-01 | 2002-03-01 | |
PCT/US2003/006233 WO2003073994A2 (en) | 2002-03-01 | 2003-02-27 | Methods of treating nerve entrapment syndromes |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005524663A true JP2005524663A (ja) | 2005-08-18 |
JP2005524663A5 JP2005524663A5 (ja) | 2006-04-13 |
Family
ID=27788996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003572516A Pending JP2005524663A (ja) | 2002-03-01 | 2003-02-27 | 神経エントラップメント症候群の処置方法 |
Country Status (7)
Country | Link |
---|---|
US (2) | US20030224019A1 (ja) |
EP (1) | EP1487481A4 (ja) |
JP (1) | JP2005524663A (ja) |
KR (1) | KR20040094756A (ja) |
AU (2) | AU2003212473A1 (ja) |
CA (1) | CA2477808A1 (ja) |
WO (1) | WO2003073994A2 (ja) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7838008B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
EP1487481A4 (en) * | 2002-03-01 | 2005-11-23 | Elan Pharm Inc | METHOD FOR TREATING NERVE TERMINATION SYNDROMES |
US7300412B2 (en) * | 2002-05-10 | 2007-11-27 | Hospital For Joint Diseases | Methods for therapeutic treatment of carpal tunnel syndrome |
US8734810B2 (en) * | 2003-10-29 | 2014-05-27 | Allergan, Inc. | Botulinum toxin treatments of neurological and neuropsychiatric disorders |
US8871224B2 (en) | 2003-12-09 | 2014-10-28 | Allergan, Inc. | Botulinum toxin therapy for skin disorders |
US20050191321A1 (en) | 2004-02-26 | 2005-09-01 | Allergan, Inc. | Methods for treating headache |
US20100266638A1 (en) * | 2004-02-26 | 2010-10-21 | Allergan, Inc. | Headache treatment method |
US9078892B2 (en) * | 2004-02-26 | 2015-07-14 | Allergan, Inc. | Methods for treating pain and for treating a medication overuse disorder |
US20050220821A1 (en) * | 2004-03-31 | 2005-10-06 | Allergan, Inc. | Pressure sore treatment |
US20050220734A1 (en) * | 2004-04-02 | 2005-10-06 | Allergan, Inc. | Therapy for melanin related afflictions |
KR100668570B1 (ko) * | 2004-06-28 | 2007-01-16 | 입센 리미티드 | 복재신경 포착에 의한 무릎 관절 통증 치료를 위한,보툴리눔 독소를 포함하는 제약 조성물 |
US6991789B2 (en) * | 2004-06-29 | 2006-01-31 | Allergas, Inc. | Methods of modulating intracellular degradation rates of toxins |
US20060024331A1 (en) * | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
US7179474B2 (en) * | 2004-09-03 | 2007-02-20 | Allergan, Inc. | Methods for treating a buttock deformity |
US7429386B2 (en) * | 2004-09-03 | 2008-09-30 | Allergan, Inc. | Stretch mark treatment |
US7897147B2 (en) | 2004-10-20 | 2011-03-01 | Allergan, Inc. | Treatment of premenstrual disorders |
US7749515B2 (en) * | 2005-02-01 | 2010-07-06 | Allergan, Inc. | Targeted delivery of botulinum toxin to the sphenopalatine ganglion |
US7655244B2 (en) | 2005-02-01 | 2010-02-02 | Allergan, Inc. | Targeted delivery of botulinum toxin for the treatment and prevention of trigeminal autonomic cephalgias, migraine and vascular conditions |
US7419675B2 (en) * | 2005-05-26 | 2008-09-02 | Allergan, Inc. | Method for treating peritoneal adhesions |
US7824694B2 (en) * | 2006-01-12 | 2010-11-02 | Allergan, Inc. | Methods for enhancing therapeutic effects of a neurotoxin |
US20070178121A1 (en) * | 2006-01-27 | 2007-08-02 | Allergan, Inc. | Methods for enhancing skin treatments |
CN101074935B (zh) * | 2006-05-19 | 2011-03-23 | 清华大学 | 探测器阵列及设备 |
US9061025B2 (en) * | 2006-08-31 | 2015-06-23 | Allergan, Inc. | Methods for selecting headache patients responsive to botulinum toxin therapy |
US8617571B2 (en) | 2008-04-03 | 2013-12-31 | Allergan, Inc. | Suture line administration technique using botulinum toxin |
US20100028385A1 (en) * | 2008-08-04 | 2010-02-04 | Allergan, Inc. | Treatment of excess cerumen secretion |
CA2774951C (en) | 2009-09-24 | 2014-12-16 | Allergan, Inc. | Method of treating osteoporosis with a neurotoxin |
US9238324B2 (en) | 2010-03-31 | 2016-01-19 | Toray Plastics (Amercia), Inc. | Biaxially oriented polylactic acid film with reduced noise level |
US9782617B2 (en) | 2010-09-19 | 2017-10-10 | Thomas Alan Ferguson, JR. | Piri-stretcher system |
US9101794B2 (en) | 2010-09-19 | 2015-08-11 | Thomas Alan Ferguson, JR. | Piri-stretcher |
US8697090B2 (en) | 2011-05-05 | 2014-04-15 | Allergan, Inc. | Method of treating persistent genital arousal disorder with a neurotoxin |
EP2649984A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis |
EP2649983A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (II) |
BR112014025396B1 (pt) | 2012-04-13 | 2020-03-17 | Lubrizol Advanced Materials, Inc. | Composto, composição cosmética ou farmacêutica, e, uso de um composto |
EP2649985A1 (en) | 2012-04-13 | 2013-10-16 | Lipotec, S.A. | Compounds which inhibit neuronal exocytosis (III) |
WO2018038301A1 (en) | 2016-08-26 | 2018-03-01 | Hugel Inc. | Stabilized liquid formulation of botulinum toxin and preparation method thereof |
EP3470054B1 (en) | 2017-10-11 | 2023-09-20 | Hugel Inc. | Microstructure formulation techniques for botulinum toxin |
US10525111B2 (en) | 2017-10-12 | 2020-01-07 | Hugel, Inc. | Microstructure formulation techniques for botulinum toxin |
US10792400B2 (en) | 2017-10-12 | 2020-10-06 | Hugel Inc. | Microstructure formulation techniques for botulinum toxin |
US10561715B2 (en) * | 2018-02-26 | 2020-02-18 | Philip Andrew RADOVIC | Plantar heel pain syndrome treatment |
EP3660509B1 (en) | 2018-11-29 | 2022-03-09 | Hugel Inc. | A cell-based method for determining an activity of botulinum toxin |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4932936A (en) * | 1988-01-29 | 1990-06-12 | Regents Of The University Of Minnesota | Method and device for pharmacological control of spasticity |
US5053005A (en) * | 1989-04-21 | 1991-10-01 | Gary E. Borodic | Chemomodulation of curvature of the juvenile spine |
US5183462A (en) * | 1990-08-21 | 1993-02-02 | Associated Synapse Biologics | Controlled administration of chemodenervating pharmaceuticals |
CA2138020C (en) * | 1992-06-23 | 1999-02-16 | Eric A. Johnson | Pharmaceutical composition containing botulinum b complex |
US5437291A (en) * | 1993-08-26 | 1995-08-01 | Univ Johns Hopkins | Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction |
US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
WO1995030431A1 (en) * | 1994-05-09 | 1995-11-16 | Binder William J | Method for reduction of headache pain |
US5512547A (en) * | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
US5562899A (en) * | 1995-02-28 | 1996-10-08 | Gerber; Allen | Medical prevention of lacerations to the vagina and perineum |
US5721215A (en) * | 1996-03-20 | 1998-02-24 | Allergan | Injectable therapy for control of muscle spasms and pain related to muscle spasms |
US6063768A (en) * | 1997-09-04 | 2000-05-16 | First; Eric R. | Application of botulinum toxin to the management of neurogenic inflammatory disorders |
US6113915A (en) * | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
US6139845A (en) * | 1999-12-07 | 2000-10-31 | Allergan Sales, Inc. | Method for treating cancer with a neurotoxin |
US6358513B1 (en) * | 2000-02-15 | 2002-03-19 | Allergan Sales, Inc. | Method for treating Hashimoto's thyroiditis |
CA2369810C (en) * | 2002-01-30 | 2007-08-07 | 1474791 Ontario Limited | Method of treating pain |
EP1487481A4 (en) * | 2002-03-01 | 2005-11-23 | Elan Pharm Inc | METHOD FOR TREATING NERVE TERMINATION SYNDROMES |
-
2003
- 2003-02-27 EP EP03709413A patent/EP1487481A4/en not_active Withdrawn
- 2003-02-27 US US10/378,042 patent/US20030224019A1/en not_active Abandoned
- 2003-02-27 JP JP2003572516A patent/JP2005524663A/ja active Pending
- 2003-02-27 AU AU2003212473A patent/AU2003212473A1/en not_active Abandoned
- 2003-02-27 KR KR10-2004-7013635A patent/KR20040094756A/ko not_active Application Discontinuation
- 2003-02-27 CA CA002477808A patent/CA2477808A1/en not_active Abandoned
- 2003-02-27 WO PCT/US2003/006233 patent/WO2003073994A2/en active Application Filing
-
2008
- 2008-03-26 US US12/056,096 patent/US20080171065A1/en not_active Abandoned
-
2009
- 2009-05-01 AU AU2009201770A patent/AU2009201770A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003073994A2 (en) | 2003-09-12 |
AU2003212473A1 (en) | 2003-09-16 |
AU2009201770A1 (en) | 2009-05-28 |
WO2003073994A3 (en) | 2004-02-05 |
KR20040094756A (ko) | 2004-11-10 |
EP1487481A4 (en) | 2005-11-23 |
US20080171065A1 (en) | 2008-07-17 |
CA2477808A1 (en) | 2003-09-12 |
EP1487481A2 (en) | 2004-12-22 |
US20030224019A1 (en) | 2003-12-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2005524663A (ja) | 神経エントラップメント症候群の処置方法 | |
Kirazli et al. | COMPARISON OF PHENOL BLOCK AND BOTULINUS TOXIN TYPE A IN THE TREATMENT OF SPASTIC FOOT AFTER STROKE: A Randomized, Double-Blind Trial: 1 | |
Yelnik et al. | Drug treatments for spasticity | |
Lam et al. | Ultrasound and electrical stimulator-guided obturator nerve block with phenol in the treatment of hip adductor spasticity in long-term care patients: a randomized, triple blind, placebo controlled study | |
Hsu et al. | Arthroscopic distension in the management of frozen shoulder | |
Sölveborn | Radial epicondylalgia (‘tennis elbow'): treatment with stretching or forearm band. A prospective study with long‐term follow‐up including range‐of‐motion measurements | |
JP4381477B2 (ja) | 筋膜疼痛症候群の治療方法 | |
Jozefczyk | The management of focal spasticity | |
Francisco et al. | Post-stroke spasticity | |
West et al. | Effective management of spinal pain in one hundred seventy-seven patients evaluated for manipulation under anesthesia | |
Vaiman et al. | Oxycodone and dexamethasone for pain management after tonsillectomy: a placebo-controlled EMG assessed clinical trial | |
Hidayati et al. | Current diagnosis and management of carpal tunnel syndrome: A review | |
El-Etribi et al. | The effect of botulinum toxin type-A injection on spasticity, range of motion and gait patterns in children with spastic diplegic cerebral palsy: an Egyptian study | |
Coroian et al. | Percutaneous needle tenotomy for the treatment of muscle and tendon contractures in adults with brain damage: results and complications | |
Marion et al. | Botulinum toxin treatment of dystonic anterocollis: What to inject | |
Cremata et al. | Manipulation under anesthesia: a report of four cases | |
Ko et al. | Spasticity | |
Hwang et al. | Effectiveness of motion style acupuncture treatment for patients with shoulder disorders: a prospective observational study | |
ZHANG et al. | Pestle needling at Yāoyángguān-Bāzhèn points for intractable lumbodynia after lumbar disc herniation surgery: A randomized controlled trial | |
Ni et al. | Community promotion of superficial needling plus club swing for post-stroke motion impairment of the shoulder joint | |
Song et al. | Observation on clinical efficacy of warm needling moxibustion plus Mulligan dynamic joint mobilization for cervical radiculopathy | |
Bursa et al. | Large and Intermediate Joint Injections | |
Elabd | Mindful meditation for chronic pain sufferers may have positive effect | |
Mo | Clinical Efficacy of Motion Acupuncture in the Treatment of Stiff Neck | |
Kamruzzaman et al. | The Effect of Phonophoresis and Therapeutic Exercise in the Treatment of Adhesive Capsulitis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060221 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060224 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20070116 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20070116 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090428 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090724 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090731 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20091027 |