KR20040092960A - Functional Composition Containing Extracts of Fruits of Hovenia dulcis var.koreana with Improved Property of Liver Function and Removal of Hangover - Google Patents

Abstract

PURPOSE: A functional food composition containing Hovenia dulcis Thunb. extract and vitamin B1 as an active ingredient is provided which has no adverse side effects on the human body and is effective for recovery of impaired liver function caused by drinking, smoking, stress or the like and removal of hangover. CONSTITUTION: The functional food composition contains 1 to 99% by weight of Hovenia dulcis Thunb. extract having a Brix of 65 to 80%, 0.0001 to 0.05% by weight of vitamin B1, 0.0005 to 0.008% by weight of vitamin B2, 0.5 to 10% by weight of oligosaccharide, 0.01 to 0.1% by weight of citric acid, 1 to 10% by weight of Daekeumeumja extract and the balance of purified water.

Description

Functional composition Containing Extracts of Fruits of Hovenia dulcis var.koreana with Improved Property of Liver Function and Removal of Hangover}

The present invention relates to a functional food composition using a natural material, and more particularly, a functional food composition that can be provided in a form suitable for drinking the extract of a predetermined concentration from the fruit of the bark, and using the extract as an active ingredient. It is about.

Generally, the bark tree is a deciduous tree of the sea buckthorn family, also called the earth-bearing tree, and is distributed in Korea (mainly distributed in Gangwon and the sub-Hwanghae), Japan and China. The bark is black gray and small branches are brownish purple and cortical. Winter snow is covered with two snow scales and has hairs. Leaves are 8 ~ 15cm long, ovate, wide ovate or oval, 3 thick leaf veins are developed, and there are fine serrated edges. Fruits are brown, about 8mm in diameter, shaped like chicken claws, and three seeds of fruit contain one seed each.

When the fruit is ripe, the fruit grows thicker and becomes lumpy, has a subtle scent, and has a sweeter taste. In the pharmacy, the herbaceous tree is said to have a decaying effect on liquor trees, and the fresh juice is said to detoxify and relieve nausea.

An example of a product using the barberry fruit is a method of manufacturing kimchi, which has been published in 2002-58589.However, there is a concern that the active ingredient accompanying the fermentation process may be lost by adding it to the kimchi from the concentrate of the barberry fruit. do. In addition, Kimchi still has a very large proportion of home-made foods, so it is impossible to create large demand in the short term.

To date, there are no functional foods known to be used as an active ingredient, and have been known to be effective in improving liver function and alcohol-degrading activity.

The present invention has been made to overcome the limitations of the prior art as described above, the main purpose of which is a functional food composition with excellent action to restore and protect the liver function damaged by drinking, smoking, stress, etc. In providing.

In order to achieve the above object, the present invention provides a functional food composition, characterized in that it contains 1 to 99% by weight of the fruit tree fruit extract of 65-80% Brix and 0.0001 to 0.05% by weight of vitamin B1 as an active ingredient. Provide food compositions.

The extract of 65-80% Brix obtained from the fruit of the bark tree is preferably added in an amount of 1-99% by weight, and when it is added in an amount of less than 1% by weight, the effective concentration having activity becomes thin and the desired functionality cannot be obtained. If it exceeds 99% by weight, as well as economical efficiency, there is a fear that the odor of the bark extract itself is strong and lacks the functionality.

Various methods can be used as a method for obtaining the extract from the fruit of the fern, but by adding 1 to 10 times the water to the weight of the fine flesh, extracting hot water at 1 to 2 atmospheres at 80 to 120 ° C. for 1 to 12 hours. For example.

The hot water extract obtained according to the above process is filtered using a known filtration apparatus, and the extract is concentrated in vacuo to 65 to 80% Brix.

Vitamin B1 prevents individual diseases and is usually effective against alcohol and fatigue. In people with excessive alcohol consumption, vitamin B1 deficiency can also cause Wernicke-Korsakoff, a serious dementia symptom. Therefore, when added as a constituent of the food composition together with the extract of the fruit of the bark, as well as the fatigue caused by alcohol and heavy rain, it can also help in the prevention of dementia symptoms.

Vitamin B1 is preferably added in 0.0001 to 0.05% by weight, and if participated in less than 0.0001% by weight, the effective concentration having activity becomes thin and the desired functionality cannot be obtained. It is uneconomical because the synergy effect is not big.

The food composition may be prepared in the form of a beverage containing purified water. For example, 10.89% by weight of 70% Brix barberry fruit extract, 0.002% by weight of vitamin B1 and the remaining amount of purified water are added. This beverage type food composition may be provided as a packaged product 30 ~ 40ml for nutritional supplement.

The food composition of the present invention may further comprise 0.0005 to 0.008% by weight of vitamin B2. Vitamin B2 is important for the growth and development of humans and prevents stomatitis and sulphate.

In particular, the food composition further comprising the vitamin B2 may be prepared in a gel type. For example, 18.000% by weight of the bark fruit extract of 70% Brix, 50.000% by weight of dextrin, 0.002% by weight of vitamin B1, 0.005% by weight of vitamin B2, 0.150% by weight of CMC-Na, and residual purified water.

It is also possible to further add Daegeumja extract that has an excellent effect on the hangover relief in the composition. When adding Daegeumja extract, although it does not require a special limitation in addition amount, Preferably it is good to add 1 to 10 weight%. An example of the preparation of such Geumumja extract is as follows.

Raw materials are selected and seasoned according to the theft and powder level in the Pharmacopoeia General Regulations. And 13.05 kg of licorice is added to the extractor, and about 2079 liters of purified water is extracted for 3 hours at 100 ° C. When the extract was about 1040 liters, the mixture was filtered under reduced pressure using a filter, and the filtrate was concentrated under reduced pressure at 700 to 750 mmHg and 50 to 60 ° C. When the water content is about 30%, the concentration is stopped to obtain about 25.78kg of lead extract (12.4% yield). In the mixing tank, add 25.78kg of the above-mentioned softening extract, 75.15kg of sweetener honey, 63.45kg of whitening agent, 1.23kg of sodium chloride, 18.75kg of excipient lactose, 0.45㎏ of sodium preservative sodium benzoate and a suitable amount of purified water, and mix well at 80 ℃. Manufacture.

Examples of the food composition of the present invention containing the Daegeumja extract obtained according to the preparation example, 18.000% by weight of the bark fruit extract of 70% Brix, 48.000% by weight dextrin, 2.000% by weight Geumjaja extract, vitamin B1 0.002% by weight, 0.005% by weight of vitamin B2 and 0.150% by weight of CMC-Na and residual amount of purified water were added. This gel-type food composition may be provided in a package of 10 to 20 ml as a nutritional supplement.

Food composition of the present invention may further comprise 0.1 to 5% by weight of vitamin C. Vitamin C is required for normal growth and development in humans, and it is also a powerful antioxidant. Therefore, vitamin C acts to neutralize cell-damaging substances in the body called free radicals, and is effective in preventing and treating aging and chronic diseases caused by alcohol and tobacco, which are easily induced by modern people.

Such vitamin C is preferably added 0.1 to 5% by weight, if less than 0.1% by weight, the effective concentration of the activity is thin, the desired functionality can not be obtained, exceeds 5% by weight Is not economical because the synergy effect of excess is not large.

In the case of preparing the food composition according to the present invention as a beverage composition, it is also possible to adjust to a suitable pH, preferably using a suitable pH adjusting agent or buffer. Here, as the pH adjusting agent or the buffer, typically, weak acids such as citric acid, tartaric acid, malic acid, lactic acid and carbonic acid and salts thereof, such as sodium citrate, ammonium citrate, sodium tartrate, sodium malate, sodium lactate, calcium lactate, and carbonic acid Sodium, sodium hydrogencarbonate, etc. can be illustrated. Sodium hydrogen phosphate can also be used as the pH adjusting agent to the buffer. These acids and its salts may be used independently and may be used together 2 or more types. These compounding ratios are suitably determined in the range in which the beverage obtained maintains the said suitable pH range. It is usually about 2% by weight or less, preferably about 0 to 0.1% by weight of the composition.

In addition, in the composition of the present invention in the form of food, such as the beverage, various sugars, sweeteners, and the like can be added and blended in the same manner as in general beverages. As a saccharide, Monosaccharides, such as glucose and fructose; Disaccharides such as maltose and sucrose; Polysaccharides (except LS), such as dextrin, cyclodextrin, etc .; Sugar alcohols such as xylitol, erythritol and sorbitol; Sugar ester etc. can be illustrated. Examples of sweeteners include natural sweeteners (such as stevia extracts such as Rebaudioside A, sormatin, glycyrrhizin, and the like), synthetic sweeteners (saccharin, aspartame, and the like). . The blending ratio of these sugars to sweetener is usually about 10% by weight or less, preferably about 0.5 to 10% by weight or less of the beverage to be obtained.

Specific examples of the food composition having the composition as described above, 0.5-10% by weight oligosaccharide and 0-0.1% by weight citric acid in the basic composition containing 2.95% by weight of fruit tree fruit extract of 70% Brix and 0.001% by weight of vitamin B1 It is possible to provide a beverage type food composition prepared by mixing and adding the residual amount of purified water. This beverage type food composition may be provided as a packaged beverage containing 150 ~ 200ml as a mixed drink.

Moreover, 1 type (s) or 2 or more types of the following additives can be added and mix | blended with this invention composition of a food form as needed, for example. Examples of the additive include various fruit juices (such as concentrated fruit juices and powder juices) such as grapefruit, apples, oranges, lemons, pineapples, bananas, and pears; Vitamins and provitamins (retinol, bisbentiamine, riboflavin, pyridoxine, cyanocobalamine, sodium ascorbate, nicotinic acid amide, calcium pantothenate, folate, biotin, cholecalcin Water-soluble and fat-soluble vitamins such as cholecalciferol, choline tartaric acid choline, tocopherol, and β-carotene; Flavorings (lemon flavor, orange flavor, grapefruit flavor, vanilla essence, etc.); Amino acids, nucleic acids and salts thereof (glutamic acid, sodium glutamate, glycine, alanine, aspartic acid, sodium aspartate, inosinic acid, etc.); Plant fibers (polydextrose, pectin, xanthan gum, gum arabic, alginic acid, etc.); Mineral to Trace Elements (Sodium Chloride, Sodium Acetate, Magnesium Sulfate, Potassium Chloride, Magnesium Chloride, Magnesium Carbonate, Calcium Chloride, Dipotassium Phosphate, Sodium Phosphate, Glycerophosphate, Ferrous Citrate, Ammonium Ferric Citrate, Citric Acid) Iron, manganese sulfate, copper sulfate, sodium iodide, potassium sorbate, zinc, manganese, copper, iodine, cobalt and the like).

The food composition of this invention is prepared by mixing each said component. The preparation method is not particularly limited, and all the necessary components may be mixed at the same time, and when using both an oil component and an aqueous component, the oil component is dissolved in a suitable oil agent in advance, and this and an aqueous solution of the water-soluble component are dissolved. It can also emulsify using an emulsifier. The emulsification operation can be carried out in accordance with a general method using a conventional emulsifying disperser, for example, a homomixer, a high pressure homogenizer, or the like according to a complete passage method or a circulation method. In addition, although mixing and emulsification of said each component are normally performed at normal temperature, a heating operation can also be employ | adopted. The composition of the present invention thus prepared is filled into a suitable container and then sterilized by heat sterilization, aseptic filtration or the like according to a conventional method, and then provided as a product.

Hereinafter, the content of the present invention will be described in more detail with reference to Examples. However, these examples are only presented to understand the content of the present invention, and the scope of the present invention should not be construed as being limited to these embodiments.

Example 1 Gel Type

According to the composition of Table 1, the nut fruit extract, dextrin, Daegeumja extract (added only to sample # 2), vitamin B1, vitamin B2, CMC-Na and the remaining amount of purified water by mixing the gel-type functional food 10 The ml containers were filled and sterilized into a final product.

TABLE 1 Content (% by weight)

ingredient #One #2 Barberry Fruit Extract (Brix 70%) 18.000 18.000 dextrin 50.000 48.000 Daegeumja extract 2.000 Vitamin B1 0.002 0.002 Vitamin B2 0.005 0.005 CMC-Na 0.150 0.150 Purified water Remaining amount Remaining amount Sum 100 100

Example 2 Beverage Type

According to the composition of Table 2, the nut fruit extract, vitamin B1 and the remaining amount of purified water were mixed and filled with functional foods of nutritional beverage type 35ml container and sterilized to prepare a final product.

TABLE 2

ingredient Content (% by weight) Barberry Fruit Extract (Brix 70%) 10.89 Vitamin B1 0.002 Purified water Remaining amount Sum 100

Example 3 Beverage Type

According to the composition of Table 3, the nut fruit extract, vitamin B1, oligosaccharides, sodium benzoate, and the remaining amount of purified water were mixed to fill a 180ml bowl of functional food of nutritional supplement type beverage and sterilized to prepare a final product.

TABLE 3

ingredient Content (% by weight) Barberry Fruit Extract (Brix 70%) 2.950 Vitamin B1 0.001 oligosaccharide 4.700 Sodium benzoate 0.020 Purified water Remaining amount Sum 100

Example 4 Beverage Type

According to the composition of Table 4, the fruit of the bark fruit extract, vitamin B1, oligosaccharides, citric acid, sodium benzoate, and the remaining amount of purified water were mixed to fill a 180ml container of functional foods for nutritional supplementation and sterilized to prepare a final product. It was.

TABLE 4

ingredient Content (% by weight) Barberry Fruit Extract (Brix 70%) 2.950 Vitamin B1 0.001 oligosaccharide 4.700 Citric acid 0.030 Sodium benzoate 0.020 Purified water Remaining amount Sum 100

Example 5 Beverage Type

According to the composition of Table 5, the fruit of the bark fruit extract, vitamin B1, vitamin C, oligosaccharides, sodium benzoate, and the remaining amount of purified water was mixed and filled with 180ml of functional foods of nutritional supplement type beverage and sterilized as a final product. Prepared.

TABLE 5

ingredient Content (% by weight) Barberry Fruit Extract (Brix 70%) 2.950 Vitamin B1 0.001 Vitamin c 0.030 oligosaccharide 4.700 Sodium benzoate 0.020 Purified water Remaining amount Sum 100

Experimental Example 1 Liver Function Improvement

In order to measure the degree of liver detoxification, the activity of GST, one of liver's important detoxification mechanisms, was measured. Each sample prepared according to the Example was added to the prepared reaction reagent and reacted at 37 ° C. for 5 minutes, and then 1-chloro-2,4 dinitrobenzene was added as a substrate, followed by reaction at 37 ° C. for 2 minutes. After the reaction, 20% TCA was added to terminate the reaction, followed by centrifugation. The supernatant was taken and measured for absorbance at 340 nm. The specific activity and activity ratio of GST were calculated as shown in Table 6 below.

Total activity (Unit) = (A340 / 9.6) × dilution factor × (3ml / 0.1) × crude extract (ml)

Inactive (Units / mL protein) = Total Active / Total Protein

% Active = inactive _{experimental group} / inactive _control × 100

<Table 6> Improvement of liver function (% / mg / ㎖)

division Liver function improvement effect Example 1 (# 1) 285 Example 1 (# 2) 295 Example 2 294 Example 3 305 Example 4 310 Example 5 311

Experimental Example 2 Hangover Test

As a result of measuring the alcohol decomposition effect according to a known method for each sample of the Example was obtained as shown in Table 7, it was shown that the alcohol decomposition effect is excellent in all samples.

TABLE 7 Alcohol Degradation Effect (% / mg / mL)

division Alcohol degrading activity Example 1 (# 1) 52 Example 1 (# 2) 53 Example 2 50 Example 3 58 Example 4 59 Example 5 59

The results showed that the alcohol decomposition effect was excellent in all samples.

Experimental Example 3 Sensory Evaluation

The sensory evaluation results of the five-point scale method of each sample of the 30 excellent taste panels were as shown in Table 8 below and were evaluated as excellent in all the test items.

<Table 8> Quality Characteristics ^♪

division color flavor Scent Overall preference Example 1 (# 1) 3.4 3.5 3.2 3.4 Example 1 (# 2) 3.5 3.4 3.2 3.4 Example 2 3.5 3.4 3.3 3.5 Example 3 3.5 3.6 3.3 3.5 Example 4 3.6 3.5 3.4 3.6 Example 5 3.5 3.6 3.5 3.5

♪ -1. Very bad. 2. It's bad. 3. It is normal. 4. Good. 5. Very good.

Since the food composition of the present invention uses natural plant material, there is no side effect, and it is excellent in restoring and protecting liver function damaged by drinking, smoking, stress, and the like. Therefore, it is possible to provide a food composition that meets the requirements of modern people who prefer high functional foods to achieve high value-added farming industry.

Claims (6)

A functional food composition, comprising 1 to 99% by weight of 65-80% Brix barberry fruit extract and 0.0001 to 0.05% by weight of vitamin B1 as an active ingredient. The method of claim 1, Functional food composition further comprises 0.0005 to 0.008% by weight of vitamin B2 The method of claim 2, Functional food composition, characterized in that the composition is in the form of a gel The method of claim 3, wherein The composition is a functional food composition characterized in that it further comprises Daegeumja extract The method of claim 1, Functional food composition in the form of a drink, characterized in that it further comprises 0.5 to 10% by weight of oligosaccharide and contains a residual amount of purified water. The method of claim 4, wherein Functional food composition further comprises 0.01 to 0.1% citric acid