KR20040035503A - The bio conjugated proteins is process of produce by natural antibiotic antioxidant function - Google Patents

Abstract

PURPOSE: Provided are bio-conjugated proteins having natural antibiotic and antioxidation activities by solid-liquid separation of enzymes, alkaloids, diploids, proteins, vitamins, inorganic matters and the like and conjugating non-protein material with pure protein to give a polymer as a bioactive material with various kinds of amino acids. CONSTITUTION: Bio-conjugated proteins having natural antibiotic and antioxidation activities are manufactured by the steps of: mixing 30g of protein, 1g of lipid, 8g of carbohydrate, 200g of sodium, 1000mg of inositol, 1000mg of luteolin, 1000mg of gingerol, 1000mg of shogaol, 1000mg of allicin, 1000mg of allinin, 1000mg of menthol, 1000mg of linolsaureglyceride, 1000mg of phytosterol, 1000mg of salinigrin, 1000mg of zingerone, 1000mg of eugenol, 1000mg of eugenin, 1000mg of glucoside, 1000mg of pomole acid, 1000mg of capsaicin, 5100mg of saporin, 5200mg of phenol acid, 1000mg of glycyrrhizin, 1000mg of riqrish, 1500mg of L-ascorbic acid, 1000mg of tocopherol, 1000mg of citric acid, 1000mg of tartaric acid, 600mg of gallic acid, 1000mg of sesamol, 1200mg of lecithin, 1000mg of phosphorus, 1000mg of beta-carotene, 1000mg of niacin, 1000mg of thiamin, 1000mg of riboflavin, 1000mg of folic acid, 1000mg of potassium, 1000mg of calcium, 500mg of magnesium, 400mg of iron, 300mg of zinc, 5000mg of tannic acid, and 10% of melanoidine; maturing the mixture at 15-20 deg.C for 20 days; drying it at low temperature, followed by hydrolysis and liquid-solid separation; and concentrating the separated products, followed by centrifugation, drying at low temperature and powdering.

Description

The bio conjugated proteins is process of produce by natural antibiotic antioxidant function}

The present invention relates to a method for the composition of a bio-combined protein having a natural antibiotic function, an antioxidant function, and more specifically, to a special component of an organism, that is, enzymes, alkaloids, glycosides, proteins, vitamins, minerals, and the like. Solid-liquid separation and purification combines nonprotein materials (conjugated substances) with simple proteins to form bioactive substances that combine various amino acids to create microbial bacteria by applying nutrient, chemical, physiological and pharmacological functions. Inhibitors and Detoxifiers To provide a method for the composition of bio-combined proteins composed of natural antibiotics.

In addition, the present invention increases the resistance of the development of microbial bacteria (virus) infection to the cells and tissues of animal plant, food preservation, protective action, physiological function, food raw materials, pharmaceutical raw materials, livestock feed raw materials, fertilizer raw materials, pollution-free pesticide raw materials, etc. The present invention aims to provide a biocombination protein composition method that has a natural antibiotic function and an antioxidant function that can maintain and promote life phenomena of life.

Conventional protein-related technologies have been used in small amounts as additives for medicine, food, and industrial use as food products from the standpoint of food engineering, where new technologies are not developed. The production and purchase environment is limited, and the dependence on imported products is high.

In addition, the price is expensive and economical price is difficult to produce and supply, and the economic and technical problems were insufficient.

Also, in terms of effects and uses, functional effects and technical challenges in developing new materials are weak and are at the stage of quality deterioration.

It is pointed out that even in the same industry, improved protein materials, namely new protein products, should be researched and researched.

Therefore, raw materials should be easy and economical, and added value should be added to secure competitiveness, import substitution effect, and global market growth. Technically, there is a great need for new bio-protein products by developing new materials according to the use.

Accordingly, the present invention is to provide a bio-complex protein by discovering a bioactive substance having a nutritional, chemically physiological and pharmacological function and forming the substance.

That is, in the present invention, antibacterial action, anti-inflammatory action, bacteriostatic action, antipyretic action, detoxification action, powerful antioxidant action, analgesic action, digestion promotion action, nutrient composition, immune function enhancement, fatigue, stress recovery function, expectoration antitussive action The present invention has been made in view of the technical problem of the present invention to provide a method for forming a bio-combined protein having a natural antibiotic function, an antioxidant function, and a protein and a nutritional substance, vitamins, minerals, and special components of an organism. It is completed.

The method for producing a composition of the biocombination protein provided by the present invention will be described in detail below.

Simple protein materials and raw materials are selected and mixed according to the composition ratio. Specific composition names and ratios of the protein material and the raw material are according to the following examples.

Mixed protein composition is aged for 20 days on average 15 ℃ ~ 20 ℃ standard. At this time, the maturation is carried out by creating a clean environment without any pollutants that maintain temperature and humidity.

When the aging process is completed, low-temperature hot air drying is performed, and the temperature is performed at about 30 to 35 ° C. The dried composition is hydrolyzed (function or hydrous ethanol, etc.), followed by solid-liquid separation.

That is, after performing the primary vacuum concentration on the basis of 50Brix at 60 ℃ ~ 70 ℃ is filtered filtration.

And second vacuum concentration is carried out at 90 ℃ ~ 100 ℃ based on 80 Brix.

The concentrate concentrated in vacuo by the vacuum concentration process is subjected to the next process.

That is, after centrifuging the concentrate

① Low temperature cooling drying → Powdered formulation (powder)

② Viscoelastic material → Store at low temperature.

And the composition of claim 1, 2, and quality control component analysis test (test score) → screening → packaging → productization.

The product prepared by the above manufacturing process is a bio-combination protein provided by the present invention, each of which is a high molecular compound combined with the composition, the molecular weight is large compared to other organic compounds to reach tens of thousands to millions.

(Example)

Composition and composition (g, mg,% per 100 g) (remarks: percentage)

Proteins (proteins that produce only a mixture of various amino acids) ... 30 g

Lipids are fats of linoleic acid, linolenic acid, and oleic acid. 1g

Carbohydrates ...... 8g

Sodium ..... 200 g

Inositol ..... 1000mg

Luteolin ..... 1000mg

Gingerol ..... 1000mg

Shogaol ..... 1000mg

Allicin ..... 1000mg

Alliin ..... 1000mg

Menthol ..... 1000mg

Linolsauregly cerid ..... 1000mg

Phytosterol ..... 1000mg

Perillaldehyde .... 1000mg

Salinigrin ..... 1000mg

Zingerone ..... 1000mg

Eugenol ..... 1000mg

Eugenin ..... 1000mg

Glucoside ..... 1000mg

Pomole acid ..... 1000mg

Capsaitine ..... 1000mg

Saponin ..... 5100mg

Phenol acid ..... 5200mg

Glricyrisin ..... 1000mg

Riqrisin ..... 1000mg

L-Ascorbic acid .... 1500mg

Tocopherol .... 1000mg

Citric acid ..... 1000mg

Tartaric acid .... 1000mg

Gallic acid ... 600 mg

Sesamol .... 1000mg

Lecithin .... 1200mg

Phosphorus ..... 1000mg

Β-caroten (beta-carotene) ..... 1000mg

Niacin .... 1000mg

Thiamin .... 1000mg

Riboflavin .... 1000mg

Folic acid .... 1000mg

Potassium .... 1000mg

Calcium .... 1000mg

Magnesium .... 500mg

Iron .... 400mg

Zinc .... 300mg

Tannic acid .... 5000mg

Melanoedin .... 10%

Total ...... 100 g

The composition as described above was formed into a bio-complex protein through the above-described manufacturing process.

The present invention prepared by such a composition and composition method bar each composition exhibits the following features and effects, collectively described as follows.

2. It is the standard of the first test product of bio-combined protein of the effective bioactive substance formed by the present invention.

According to the test analysis result by the inventor in his laboratory, it is a product standard specification for food use.

Test result: Based on the ingredient content per 100g of sample. (Unit, g, mg, μg,%)

The complex protein produced was a material having viscoelastic properties with a characteristic aroma, sweetness, sourness, slightly bitterness and rich taste. And the composition ratio in the complex protein was as follows.

Proteins .... 29 g

Inositol ..... 1186mg

Luteolin ..... 892mg

Gingerol ..... 938mg

Shogaol ..... 989mg

Allicin ..... 896mg

Menthol ..... 798mg

Linolsauregly cerid ..... 962mg

Phytosterol ..... 981mg

Perillaldehyde .... 992mg

Salinigrin ..... 968mg

Zingerone ..... 997mg

Eugenol ..... 912 mg

Eugenin ..... 918mg

Glucoside ... 969 mg

Pomole acid ... 820 mg

Capsaitine ..... 932mg

Saponin ..... 5088mg

Phenol acid ..... 5165mg

(as total phenol measured by chlorogenic acid)

Melanoedin .... 10%

Tannic acid .... 4980mg

Glricyrisin ..... 968mg

Riqrisin ..... 899mg

Lecithin .... 1136mg

L-Ascorbic acid .... 1163mg

Tocopherol .... 988 mg

Citric acid ..... 992mg

Tartaric acid .... 860 mg

Gallic acid ... 530 mg

Sesamol .... 980mg

Β-carotene (beta-carotene) ..... 987g

Niacin (...

Folic acid .... 986 mg

Thiamin .... 790mg

Riboflavin .... 713 mg

Phosphorus ... 930 mg

Potassium .... 980mg

Calcium .... 858mg

Magnesium .... 496mg

Iron .... 338 mg

Zinc .... 292mg

Lipids ..... 1.0g

Carbohydrates ...... 8g

Ashes ..... 1.0g

Sodium ..... 150 g

Kcal (calories) ... 160

Tar pigment, heavy metal, and arsenic were not detected, and coliform group and colon group were negative.

3. Nutritional, chemical, physiological and pharmacological functions, functions and effects are as follows.

(1) The function and action will be described in the state in which the composition to be composed is bonded.

Its antibacterial effect is remarkable to inhibit the development of Staphylococcus aureus, hemolytic streptococci, skin improvement bacteria, Mycobacterium tuberculosis, Influenza bacteria, Diphtheria bacteria, Pneumococcal bacteria, Pertussis bacteria, Heterogeneous bacteria, Pseudomonas aeruginosa, Cholera bacteria and Escherichia coli.

· Anti-inflammatory action inhibits inflammation and promotes analgesic and white blood cell phagocytosis, dilates skin vessels, stimulates glands secretion, and makes sweating and antipyretic effect is remarkable.

· Reduces bronchial secretions, releasing spasm of bronchial smooth muscle, expectorant, antitussive action is remarkable.

Malaria virus, pandemic virus to suppress the action is excellent.

· Enhance lymphoid blast cells to increase resistance to bacterial infection and boost immune function.

· Promotes bile secretion, promotes digestion, and diuretic.

Corticosteroids such as adrenal cortex hormone and insulin appear. And the generation and detoxification of cytoplasm with collagen (collagen) as a substrate.

· Antioxidant natural antioxidants help antioxidant activity and show synergist strong antioxidant properties.

(2) It is the main compositional substance which is constituted, and it is a main functional action by the unit which combined the substance which has the property of the same and similar functional action with each substance unit.

Primary Composition Constituent Units: Primary Functional Functions

Proteins: Made of high-quality amino acids, it is an excellent source of digestive and absorbing nutrition in the body, regulating lipid metabolism in the body, promoting fatigue recovery due to nutritional properties, promoting fermentation, resistance, physical properties, improving autonomic nerve regulation, hematopoiesis, anti-inflammatory, It is a new bioactive substance that is very important for nutritional maintenance, such as anti-stress and anti-allergy, pain relief, anti-oxidation and nourishing tonic.

Carbohydrates: Essential nutrients as energy sources and important properties as a plant. Soluble in water and alcohol, insoluble in ether, soluble. As a reducing action of the sugar, there is an action of reducing other substances by the oxidation resistance of the aldehyde group or the ketone group.

Formation of Glycosides: Combines with alcohols and phenols to form a substance called glycosids.

Ester production: Works with acids to make esters.

Fermentability: Decomposes under the action of yeast to produce alcohol and carbon dioxide.

Acid, alkali action: aldose is a weak alkali that causes intramolecular potential. For example, glucose turns into fructose or mannose. Strong alkalis are easily oxidized and are oxidized by oxygen in the air to produce formic acid lactic acid. The addition of strong acids also dehydrates and carbonizes with concentrated sulfuric acid.

Lipids: Fats are burned in the body like carbohydrates and are a heat source, so they can be borrowed by carbohydrates, but they have a physiological effect that cannot be substituted for other nutrients.

Highly unsaturated fatty acids such as linoleic acid and linolenic acid are mainly present in important physiological organs, and they are reported to be indispensable for life support by special physiological functions and have significance as therapeutic nutrients.

A common physiological effect of fat containing linoleic acid, linolenic acid, oleic acid, etc. It is effective for sore throat, bronchitis, dermatitis, anti-allergy, menstrual progesteria prevention, blood cholesterol reduction, obesity prevention.

Unsaturated fatty acids: Lowers cholesterol β-lipoproteins and other lipids in unsaturated fatty acids. Unsaturated fatty acids have one or more double bonds.

Oleic acid (cH3) -c (cH2) 7-cH = cH- (cH2) 7-cooH

Linoleic acid cH3-c (cH2) 4-cH = cH-cH2-cH = cH- (cH2) 7-cooH

Linolenic acid cH3- (cH2-cH = cH3- (cH2) 7-cooH

Vegetable oils such as cottonseed oil, soybean oil, safflower oil and corn oil contain large amounts of monounsaturated and polyunsaturated fatty acids. In particular, safflower oil contains the highest 80% linoleic acid (polyunsaturated fatty acid). Animal fiber and hardened vegetable oils contain very low levels of unsaturated fatty acids.

Vegetable oils containing high levels of unsaturated fatty acids instead of saturated fatty acids reduce serum cholesterol in most people. This increases the transport and excretion of cholesterol. In the absence of unsaturated fatty acids, cholesterol is esterified with saturated fatty acids and deposited in tissues. Polyunsaturated fatty acids also increase the excretion of bile acids.

In steady state, cholesterol forms esters with arachidonic acid to become serum cholesterol. Unsaturated acids such as linoleic acid and linolenic acid act as Arachidonic acid under pyridoxine catalyst in the body.

Absorbed well orally. Occasionally, diarrhea can come. No toxicity

Application: hypercholesterolemia, cardiac infarction, hypertension, obesity, diabetes, bone joint disease, nicotine poisoning, cold

Inositol, Luteolin, Gingerol, Shogaol, Shogaol, Allicin, Alliin, Menthol, Menthol, Linolsauregly cerid De), Phytosterol (Phytosterol), Perillaldehyde (Perylaldehyde), Salinigrin (Salinigreen), Eugenol (Augugenol), Eugenin (Augugenin), Glucoside (Gucoside), Pomole acid (Pomolic Acid), Capsaicine (Capsaicin ), Zingerone, and Proteins: They have high anti-bacterial, analgesic and antipyretic effects, inhibiting the growth of bacteria, and inhibiting the proliferation of inflammation.

Strong divergence acts as a cold due to externality, fever and headaches to relieve sweat.

It enhances humoral and cellular immune function, and has a certain inhibitory effect on hemolytic streptococci, cholera, tuberculosis, influenza virus, and malaria. Expectant phlegm, coughing and discharge of cough was very good.

Promotes digestion and diuretic effect. It has an antiseptic effect on food, and it has an aromatic property, which stabilizes the mind and promotes the circulation of the qi, and the effect of eliminating vomiting due to tingling of the stomach and tingling of the chest and the name is remarkable.

Relieves nasal congestion and eye strain.

Phenol acid, Melanoedin, Melanoedin, L-Ascahic acid, Saponin, Saponin, Tocopperol, Glricyrisin, Glycyrisin, Riqrisin, Liquerisin, Potassium ): They normalize the metabolism of proteins, especially amino acids such as tyrosine, phenylalanine and tryhtophan. It has a detoxifying effect and has a remarkable effect on drug poisoning and toxic substances. It is also involved in oxidative detoxification of Benzene and other cyclic compounds.

Control action is shown to control the cold and hot properties. Diabetic Rats have a hypoglycemic effect on antidiabetics.

Tannic acid, Tartaric acid, citric acid, Citric acid, Gallic acid, Sesamol, Lecithin, Phosphorus, Phosphorus, L-Ascorbic acid Scrobinic acid), Tocopherol, Phenol acid, and β-carotene (beta-carotene): They exhibit potent antioxidant, astringent, and mutagenesis effects.

Since these substances are antioxidants, they help antioxidant activity, so they have a high residual ratio as a synergist, and have a physiological activity that plays a role as a strong antioxidant and inhibits DNA damage caused by harmful carcinogens in vivo. Antimutagenicity using the Ames test, a mutagenicity test, showed that the inhibitory effect on mutagenicity of cells induced was also very large.

Its value and potential as a dietary factor for disease resistance and cancer prevention.

Thiamin: Thiamin is indispensable for the metabolism of carbohydrates. When deficient, intermediates of carbohydrates such as pyruvic acid and methylglyoxal build up in the body, causing incomplete combustion of carbohydrates.

Thiamin pyro phosphate binds to lipoic acid and functions.

Since vitamin B1 is required for carbohydrate metabolism, there is a relationship between the amount of carbohydrates in plants and the requirement of vitamin B1.

It is a coenzyme that acts on the pyruvate system.

There is also an inhibitory effect of cholinesterase.

A new derivative of thiamin is allithiamine. Feeding animals with this action on vitamin B1 has the same physiological effects as vitamin B1. It has a chemical formula.

Thiamin deficiency symptoms: Each of these symptoms is caused by a lack of thiamine and other B vitamin complexes. People have poor growth, loss of appetite, indigestion, constipation, peripheral neuritis, nerve pain in the feet, short and long muscle pains, femoral muscle pain, ataxia, paralytic optic neuritis, enlarged heart, swollen legs, arms and hands. It causes alcoholism and neuritis such as fatigue, lowered blood pressure, increased pulse, palpitations, and sleep disorders. Potential vitamin B1 deficiency is sometimes seen. There is a certain amount of storage in the body, and excess thiamine ingested is excreted in the urine. Therefore, when the excess amount is large, the amount of excretion is also large.

Its applications include the use of prophylaxis, appetite promotion, neuromuscular pain, neuritis, gastric ulcers, gastritis, cold symptoms, fatigue, nicotine addiction.

Riboflavin: Riboflavin is primarily a flavin mononucleotide, flavin ademin dinucleotid, and is a coenzyme of several enzymes in vivo. When this catalyzes the oxidation reaction in the body, it takes the hydrogen atoms from the substance to be oxidized and becomes the leucoflavin type, and the leucoflavin type (reduced form) is oxidized by cytochrome or oxygen again. Degradation of Fatty Acids Oxidizes pyruvic acid in the nervous system.

Examples of enzymes that use FAD as a coenzyme include D-amino acids, oxidase diaphorase maldehyde oxidase, xanthine oxidase, and glucose oxidase.

Vitamin B2 is more often found in animals as FAD than in FmN.

Riboflavin deficiency causes inflammation of the tongue. Oral stomatitis (opening of lips and lips; seborrheic, dermatitis)

Dermatitis, nasolabial folds and elsewhere dermatitis occurs. Anorexia.

It is widely distributed in the body and excess is excreted in the urine. There is no obvious toxicity.

Its application is used for Riboflavin and general vitamin B complex deficiency. No toxicity Gastritis, gastric ulcer, fatigue, neurological activity. Nicotine addiction.

L-Ascorbic acid: L-Ascorbic acid is easily oxidized and reduced in the body, which plays a large role in physiology. As a strong reducing substance, it acts as an enzyme to maintain redox conditions suitable for many enzyme activities.

A chemically pronounced property is the reversible oxidation-reduction system. That is, ascorbic acid is oxidized to reduce dehydroascorbic acid. In humans, there is an inverse reaction between glutathion and ascorbic acid in the blood. Metabolism of proteins, in particular amino acid metabolism of tyrosine phenylalanine and tryhtophan normalizes. When tryrosin is fed to an ascrobic acid-deficient morphot, abnormal intermediates are excreted in the urine.

Tryrosin is decomposed through hydroxyphenyl pyruvic acid, dihydroxyphenyl pyruvic acid and homogentisic acid. When deficient in ascorbic acid, these substances are excreted in the urine, but these are lost when ingested ascrobic acid.

Ascorbic acid is associated with the production of corticosteroids, and when deficient, cholesterol is deposited in the adrenal glands, resulting in a loss of cortical hormone production. It also causes deficiency of insulin when it is deficient. If you are deficient in ascorbic acid, eating insulin will not lower your blood sugar.

Ascorbic acid deficiency decreases the activity of oxidase and hydrolase in body tissues. Collagen is necessary for the production of intercellular matrix as a substrate. Without ascrobic acid, interstitial cells, ie, fibrous tissue, bone tissue, and dentin are not formed, and capillary rupture occurs.

Detoxification is involved in the oxidation and detoxification of Benzene and other cyclic compounds. Ascorbic acid is easily absorbed by the intestinal tract, and the organs with high metabolic activity are high in the retina, pituitary gland, corpus luteum, adrenal cortex, brain and pancreas.

Deficiency is a significant pathological symptom of the loss of intercellular material formation. In bones, vitamins deficiency prevents osteoblasts from forming intercellular substances, osteoids. Without osteoid, no calcium deposition. The result is that the bones are fragile and brittle, and the long-bone epiphyse is enlarged, resulting in joint pain.

In teeth, intercellular cement collagen, dentine and osteoid formation failed, and teeth shake. Hemorrhagic phenomena occur due to fragile capillaries in mesenchymal supporting tissues.

Therefore, if the teeth are swaying or falling out, the roots are sore and receding, internal bleeding or subcutaneous bleeding with minor injuries, arthritis pain, shortness of breath, edema, anemia, scurvy disease, decreased resistance to bacterial infection, boredom fatigue, detoxification function, Dry skin, dysplasia, diabetes complications of malnutrition, antioxidant ascrobinic acid, tocopherol, alpha lipoic acid, etc. are strong antioxidants to prevent the damage of free radicals to arteries in diabetics and to prevent blood vessels from narrowing. It is effective in preventing and binding glucose and protein binding. Diabetic neuropathy is particularly effective for neurological disorders in the limbs. Steady research should be developed in the future.

Its application is effective in deficiency, diabetes, neural arthritis, hypertension, scurvy, anemia, obesity due to edema, cold symptoms, fatigue, immune system, antistress, nicotine poisoning.

Folic acid: Folic acid is a complex of glutamic acid, P-aminobenzoate and pteridine. Pteridine bound to P-aminobenzoate (PABA) is pteroic acid, and folic acid itself is also called Pteroyl glutamate (PGA). There are at least three folic acids in nature, and these formulas differ only in the number of glutamic acids attached around the pteroid acid. One example is FH4 (5,6,7,8, tetra hydrofolic acid), one of the analogues. This reduces folic acid.

The important action of folic acid derivatives is to act as a coenzyme for transmethylation and to donate a single carbon (one-carbon, c1) moiety. For example, n-formyl-methionine, which is used for tRNA synthesis, initiates peptide chains in ribosome, or enters beta (β) -carbon when serine is synthesized in glycine.

Required for DNA synthesis Thus, deficiency of folic acid impairs the synthesis of DNA and impairs growth in animals. It is widely distributed in fresh green vegetables, soy sauce, and kidneys.

The substance of the folic acid group prevents anemia due to malnutrition and has a therapeutic effect and promotes the growth of microorganisms.

Folic acid is involved in the synthesis of the nucleic acids, purin and pyrimidine. It is also involved in the reaction of formic acid to the methyl group of methionine or choline in the liver. In addition, the ability to oxidize tyrosine decreases.

The active forms of folic acid are 5-formyltetrahydrofolic acid 10-formyltetra-hydrofolic acid and 5-methyltetrahydrofolic acid.

Vitamin-C works more effectively with folic acid in the treatment of anemia, so in the absence of vitamin C, more folic acid should be eaten. Folic acid also acts as a coenzyme, due to its reduced form.

That is, dihydrofolic acid (FH2) and tetrahydrofolic acid (FH4) are the reduced forms. An important coenzyme of FH4 is the translocation of the C1 fragment. Toxic

As a result of this deficiency, anemia comes when a person lacks folic acid. (macrocytic anemia) This anemia is different from pernicious anemia. In pernicious anemia there are neurological symptoms. Anemia and pernicious anemia are healed, but neuralgia is not healed but vitamin B12. Symptoms include diarrhea, nervous gastritis, indigestion, and poor growth.

Its application is used for anemia (dietary, pregnant, childhood) and sprue anemia and scurvy.

However, it is not effective for gliadine toxicity. Stomach ulcers, Helicobacter pyro inhibitory effect, cold anemia, nicotine poisoning.

Niacin: Nicotinamide has two coenzymes. Nicotinamide adenine dinucleotides (NAD, DPN, coenzymel) and nicotinamide dinucleotide phosphates (NADP, TPN, coenzymell) and the conversion of nicotinic acid to nicotin amide occur in the kidneys, brain, and parts of the liver and glutamine in the liver. Biosynthesis of NAD + reduces NAD + or NADP + when the substrate is oxidized by NAD + or NADP + dependent enzymes.

In the reduction, one hydrogen atom in the substrate is added to the nucleotide and the other forms H +.

Chemical reaction of nicotinic acid It is a structural part of NAD + and NADP + and it undergoes redox reaction with many dehydrogenases. In summary, the biochemical reactions depend on these enzymes.

Synthesis of High Energy Bonds

Metabolism of Pyruvate

Metabolism of pentose

Carbohydrates and Fat Metabolism

Nitrogen metabolism (oxidative amino leaving reaction of amino acid)

Vasodilation.

Symptoms of deficiency include pellagra and healing vitamins.

Tongue inflammation, dermatitis, brain disease (cause of dementia), diarrhea, gastrointestinal disorders, fatty degeneration comes.

Its application is orally well absorbed, nontoxic, widely distributed in the body, mostly trigonelline, and excreted during urination. Used to prevent and treat pellagra. Migraine, angina pectoris, hypertension, hyperlipidemia, arteriosclerosis, neuralgia, skin disease, insomnia, nervousness, memory loss, delirium, blood sugar control, indigestion, constipation (rotation), cold pain nicotine poisoning.

Tocopherol: Tocopherol is a substance with chroma nuclei, which is divided into three types of tocopherols, α (alpha), β (beta), and γ (gamma), depending on the location and number of CH3 groups attached to the nucleus. -γ (gamma) -tocopherol has the strongest effect. Soluble in fat. It is stable against heat and does not decompose even when heated. It is hardly affected by oxygen. In addition, it itself has strong antioxidation property (vitamin A), vitamin A and carotene unsaturated fatty acid is easy to be oxidized, but vitanim E is added to prevent oxidation. The absorption spectrum of vitamin E is maximal at γ (gamma) -tocopherol and 293mu β (beta) -tocopherol.

Distributed in the vegetable world Vegetable oil, green vegetables are many. It is also distributed in the liver. Tocopherol is absorbed in the small intestine and fats and bile acids promote it. In the body, it is stored in adipose tissue, muscle, and liver. It is also a vitamin necessary for the breeding of animals. Without vitamin E, sperm-producing epithelial cells in males denature the testicles, and sperm production activity is reduced, causing infertility. In females, ovulation and estrus occur, but normal conception and childbirth occur and the pups die and are reabsorbed by the mother or aborted.

Symptoms of deficiency include muscle atrophy, poor growth, habitual miscarriage (causes reproductive insufficiency and complete delivery of vitamin E to women with miscarriage), heart disease, diabetic complications, and capillary disorders.

Its applications include habitual miscarriage, heart disease, myalgia, frostbite, diabetes complications, high blood pressure, arteriosclerosis, gastric ulcer, gastritis, duodenal disease, anti-aging, cold pain, nicotine poisoning.

Calcium (calcium, Ca): Normal blood is weakly alkaline (pH 7.4). Minerals play an important role in maintaining neutrality in the body. Calcium is a phosphate and carbonate that is found primarily in the skeleton and teeth, and some in the blood muscle nerves. 85% of the salts in the backbone are calcium phosphate and about 10% are calcium carbonate. 99% of the total amount of calcium in the body contains the skeleton, the remainder is 1% in the blood.

Makes the blood alkaline, promotes blood coagulation, strengthens the heart's contractile force and suppresses muscle excitability. Sedatives to calm the sensitivity to nerve stimulation, activating enzymes, phagocytosis of leukocytes is vigorous and increases resistance to disease. Less calcium in the blood tends to cause muscle spasms and increases the permeability of capillaries and cell membranes.

Calcium in the food is soluble by the hydrochloric acid action of the stomach is absorbed in the intestine. The absorption of calcium requires the help of vitamin D, and lysine and arginine also promote its absorption. On the contrary, oxalate and phytate form calcium and insoluble salts, making it difficult to absorb. Calcium is required in a period of strong skeletal growth.

Digestive fluids have normal acid properties and have adequate vitamin D to improve calcium absorption. Calcium is absorbed directly into the plasma, which is always maintained by a parathyroid hormone (10 ml to 100 ml) and is always metabolized.

Deficiency symptoms: poor growth, rickets, osteomalacia, arthritis, osteoporosis, decreased activity, decreased meals, abnormal posture and gait, internal bleeding, increased urine volume, shortened life span, arteriosclerosis, indigestion

Its application is effective in deficiency symptoms, arthritis, osteoporosis, rickets, arteriosclerosis, thrombosis, phlebitis, diabetic complications, gastrointestinal diseases (antacids)

Magnesium: Magnesium is a constituent of bones such as phosphorus and calcium. It is contained in bones as phosphates and carbonates, and in other soft tissues such as muscles and body fluids.

Magnesium in the body fluids maintain the alkalinity and have the antagonistic action opposite to calcium, and a lot of magnesium is the result of driving out calcium, while lacking it interferes with the metabolism of calcium.

Magnesium is associated with magnesium deficiency and insulin resistance in cells. The more magnesium you eat, the lower your risk of diabetes. In general, fiber-rich foods are also rich in magnesium.

Magnesium metabolism is similar to phosphorus because it is a component of bone and soft tissues such as magnesium and phosphorus. It acts as a coenzyme of kinase, and when carbohydrates burn in our body, it forms phosphate and promotes calcium phosphate. It reacts with gastric acid and acts as an antacid and is unlikely to cause alkalosis. This is also the action of mg + + has a downward action.

Symptoms of deficiency include vasodilation, hyperemia, nerve hypersensitivity, poor growth, hair loss, gum inflammation, excess acid, and indigestion.

Its application is also deficiency symptoms such as antacids, diabetes, constipation, bone disease.

Iron: About 60% of iron in the human body is contained in the blood, and the other iron is accumulated in the liver, spleen, bone marrow, etc., 30% myoglobin muscles, hemoglobin cells in the cytochrome. It contains 1.0-1.7mg% in blood, 0.08-0.17mg% in plasma, and about 0.33% in hemoglobin. Hemoglobin is a protein with iron and plays an important role in oxygen transport.

Ingested iron is absorbed mainly in the upper part of the small intestine. The absorbed iron passes through the liver to the hematopoietic bone marrow, which is used to form hemoglobin.

Iron in foods varies in the body depending on its type. For iron to be absorbed, it must be of Ion Mars.

The absorption of iron is reduced when there is a lack of hydrochloric acid in the gastric juice. Ascorbic acid and other reducing compounds in plants enhance the absorption of iron.

In the second trimester, iron absorption increases due to the fetal accumulation of fetuses. A substance that modulates the absorption of iron is the ferritin of the mesenteric membrane, which is an iron-containing protein.

Fe ++ is more effectively absorbed than Fe ++. Diets high in phytate phosphate (milk) or alkalizing agents used by patients with gastric ulcers reduce iron absorption. Iron acts as a component of hemoglobin for metabolism in the body. The daily physiological requirement of iron is 1-3 mg, normal menstruation 2-3 mg, growth stage 2-3 mg, pregnancy 3-4 mg, iron is excreted about 1 mg per day, stool, urine, sweat. Re-use of iron is about 25mg per day.

Excess: Due to toxicity, increased iron absorption in the intestine causes various blood diseases according to increased red blood cell formation. Hemochromatosis

Its deficiency symptoms include poor growth, anemia, nervousness, fatigue, and changes in nails.

Its application is also valid for deficiency symptoms. neuralgia.

Zinc (Zn): Zinc is present in all animal tissues, especially in the liver and pancreas. The pancreas contains zinc and has been identified as a component of the hormone hormone hormone. In other words, zinc not only promotes the action of Insulin, but also continues the action. Pancreatic insufficiency and the cause of diabetes need to be analyzed.

The most vigorous metabolites are the liver, pancreas, and pituitary gland, which are metabolized slowly in red blood cells, brain fractures and skin. Most of Zn was excreted in feces and small amount was excreted in urine. It was not related to proteinuria, but it was confirmed that urine poisoning, tuberculosis patients, diabetes patients, and dementia patients were found slightly in the urine. This is considered to be related to the functional state of the kidney.

Its deficiency symptoms include poor growth, skeletal insufficiency, skin disease, decreased appetite, decreased food utilization, gonads, and reduced resistance to disease. The application of this deficiency is effective in deficiency symptoms and can be applied to diabetes and senile dementia diseases. In progress, colds, immune function, nicotine addiction.

And zinc is needed to study the role of endocrine hormones and metabolism.

Phosphorus (P): Phosphorus is an indispensable component of all tissue cells in living organisms and plays the most essential role in life. Most of the 80-90% is contained in the skeleton and teeth as calcium and magnesium phosphate, in addition to the muscles, brain, nerves, liver, lungs. Protein fats are also in the blood. The metabolism is more active than that in the skeleton.

Enzymatic action, neutralization of body fluids, nerve stimulation conduction, osmotic pressure control, absorption, secretion and the like. Phosphorus compounds also play an important role in the metabolism of fats and carbohydrates, and po4 in the blood combines hexasaccharide and anhydrous glucose to play a major role in carbohydrate oxidation.

Phosphorus compounds (phospholipids, etc.) that make up the cranial nerve tissue are not only components of human tissue, but are also involved in stimulating conduction.

Vitamin D increases calcium absorption but has little effect on phosphorus. However, organic phosphates in soft tissues turn into inorganic phosphates and accelerate in deposition in the bone.

Phosphorus is absorbed by the intestinal tract, and the body's full-featured phosphorus is excreted mainly in the urine and traces of feces.

Children and growth stages require a relatively large amount of phosphorus than adults.

Too much phosphate inhibits the absorption of iron, but ingesting the right amount of calcium can prevent this function. When calcium is fortified in food for the purpose of calcium supplementation, calcium is used other than phosphate.

Deficiencies include growth disorders, loss of appetite, rickets, weakness, muscle joint weakness, and endocrine metabolic disorders.

Its applications include diabetic complications, malnutrition in children, menopausal disorders, weakness, arthritis, patient recovery health promotion, nicotine addiction, colds.

As described in detail above, the bio-complex protein provided in the present invention provides a number of effects as follows.

1. Its antibacterial effect is remarkable to inhibit the development of Staphylococcus aureus, hemolytic streptococci, skin improvement bacteria, Mycobacterium tuberculosis, Influenza bacteria, Diphtheria bacteria, Pneumococcal bacteria, Pertussis bacteria, Heterogeneous bacteria, Pseudomonas aeruginosa, Cholera bacteria and Escherichia coli.

2. It has anti-inflammatory action, inhibits inflammation, promotes analgesic and white blood cell phagocytosis, dilates skin vessels, stimulates glands and makes sweating, and antipyretic effect is remarkable.

3. The bronchial secretion is reduced by releasing the spasm of bronchial smooth muscle, expectoration, phagocytosis is remarkable.

4. Malaria virus, pandemic virus to suppress the action is excellent.

5. Enhance the lymphocytes, increase the resistance to bacterial infection and promote immune function.

6. Promotes bile secretion and promotes digestion and diuretic effect.

7. Adrenal cortex hormone and insulin (Insulin) hormone secretion is shown. And the generation and detoxification of cytoplasm with collagen (collagen) as a substrate.

8. Antioxidant natural antioxidants help antioxidant activity, so synergist shows strong antioxidant properties.

Claims (3)

Protein 30g, Fat 1g, Carbohydrate 8g, Sodium 200g, Inositolitol 1000mg, Ludeolin 1000mg, Gingerol 1000mg, Shogaol 1000mg, Allicin 1000mg, Alinine 1000mg, Menthol 1000mg, Linolesoreglyceride 1000mg, Phytosterol 1000mg, Peryl Aldehyde 1000mg, Salinigreen 1000mg, Gingeron 1000mg, Auggenol 1000mg, Augustinin 1000mg, Glucoside 1000mg, Formic Acid 1000mg, Capsaicin 1000mg, Saponin 5100mg, Total Phenolic Acid 5200mg, Glycirizine 1000mg, Licuricine 1000mg, L-Asthrovin Acid 1500mg, Tocopherol 1000mg, Citric Acid 1000mg, Tartrate 1000mg, Molecular Acid 600mg, Sesamol 1000mg, Lecithin 1200mg, Phosphorus 1000mg, Beta-Carotene 1000mg, Niacin 1000mg, Chiamin 1000mg, Riboflavin 1000mg, Folic Acid 1000mg, Potassium 1000mg, Calcium 1000mg, 500 mg of magnesium, 400 mg of iron, 300 mg of zinc, 5000 mg of tannic acid, and 10% of melanoidine were mixed to form a composition. Aging the composition for 20 days on an average of 15 ℃ to 20 ℃ standard, and Performing the low temperature hot air drying when the aging process is completed, When the drying process is completed and the first and second solid-liquid separation after hydrolysis, A method for forming a bio-complex protein having a natural antibiotic function and an antioxidant function, characterized in that the concentrated solution vacuum concentrated by the solid-liquid separation vacuum concentration process is centrifuged, and then cooled and dried under low temperature cooling. The method of claim 1; The first solid-liquid separation process is a bio-combined protein composition method characterized in that the natural antibiotic function, antioxidant function, characterized in that the vacuum concentration on the basis of 50Brix at 60 ℃ ~ 70 ℃. The method of claim 1; The second solid-liquid separation process is a bio-combination protein composition method having a natural antibiotic function, antioxidant function, characterized in that the vacuum concentration on the basis of 80Brix at 90 ℃ ~ 100 ℃.