CN101428037B - Anti-apolexis composition containing repair factor - Google Patents
Anti-apolexis composition containing repair factor Download PDFInfo
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Abstract
The invention discloses antiaging composition which contains repair factors and can realize synergism to the body on multiple layers and in multiple sites. The composition comprises vitamin c, oligomeric proantho cyanidins, gadol glycoside, vitamin B6, vitamin B1, vitamin B2, nicotinic acid, taurine, arginine, lysine, inositol and zinc salt. The components of the composition are integrated all sidedly with key points and pertinency according to the physiological characteristic of human body, the recombined repair factors can better exert the synergistic effect, completely repair the activity of cells, tissues and organs of the human body, and inhibit bio-garbage generated by metabolism, thereby improving the aging symptom of the human body and preventing sub-health.
Description
Technical field
The present invention relates to a kind of health promoting product, specifically a kind of anti-apolexis composition that contains reparative factor.
Background technology
In recent decades, along with human civilization, living standards of the people improve rapidly, and when enjoying the modern civilization achievement, modern civilization diseases such as hypertension, hyperlipidemia, hyperglycemia, coronary heart disease, diabetes, obesity, cancer are also having a strong impact on our health and lives.
According to World Health Organization (WHO) statistics, modern disease is because people's bad life habits, due to the severe contamination of Bad Eating Habit and environment, food, air, water quality.The number of national trouble cardiovascular and cerebrovascular disease reaches 3.25 hundred million at present, accounts for 25% of national population, and what bad life habits caused in above-mentioned these causes of the death accounts for 47%; Account for 89.1% because of what bad consumption type caused.The expert points out: China 40% obese patient is arranged at present since lipid metabolism unusual-lipogenesis increases, decompose reasons such as slack-off, finally cause hypertension, hyperlipidemia, the generation of diseases such as coronary heart disease, therefore the modern civilization disease has become the stealthy killer of serious threat human health, particularly recent two decades comes popularizing of many household electrical appliance, the pollution that a large amount of acousto-optic magnetic radiations is caused, having quickened above-mentioned crowd swashs according to increase, and constantly develop to the direction that becomes younger, simultaneously sub-health population also becomes younger rolling up and tend to, and the human internal environment has been proposed more serious challenge.According to China's Development of Health Service situation in 2000 statistical communique, first of urban area resident's cause of the death is malignant tumor, is cerebrovascular, heart disease secondly.The most common and serious tumor of hazardness of China is pulmonary carcinoma, nasopharyngeal carcinoma, the esophageal carcinoma, gastric cancer, colorectal cancer, hepatocarcinoma, breast carcinoma, cervical cancer, leukemia and lymphoma etc.
Along with medical science, threpsology, hereditism, genetics, development of molecular biology, the mechanism of action of the functional component that many nutrients, medicine, animals and plants are extracted has all obtained further investigation, and extensive use promotes the well-being of mankind, the particularly research of defying age aspect, human life-prolonging secret is progressively clear.
Free radical theory is thought: aging is because the damage of radical pair cell and tissue causes.
The nonenzymatic glycosylation theory is thought: the proteinic crosslinked damage that nonenzymatic glycosylation causes is old and feeble main cause.The proteinic crosslinked sclerosis that glycosylation causes and gradually degeneration be to cause blood vessel, kidney, the lobe of the lung and joint to shift to an earlier date aged key factor.Cause the sclerosis of structural protein thus, the damage of functional protein decrease to become etc. as the rheological properties that increases of antioxidase and DNA repairase.Also can cause the minimizing of energy supply, the reduction of metabolic function, imbalance of balance performance or the like catabiosis.
Modern life science research clearly confirms, the constantly manufactured in vivo metabolism rubbish that comes out the most dangerous, maximum again, or claim " toxin " to be mainly the undersaturated carbonyl toxoid of a big class.
First road defence of organism defence " subhealth state " and " stress be sick " is exactly well-known antioxidant system, comprises the effect all linked with one another of antioxidant and antioxidase.The defence of second road, " anti-carbonyl poisons " comprised the biochemical essential main contents of aging course, and the defence of the 3rd road is restoration updating, belongs to final the getting of biological tissue and abandons choice.The enzyme of great assistance glutathion removing carbonyl toxin is referred to as glutathione transferase in the body.Remove the carbonyl class toxicity biologic garbage that constantly produces and accumulate in the body, also just removed the biological basis of old and feeble substance accumulation, equally also just removed the biological basis of old degenerative disease substance accumulation.
Carbonyl poisons the most crucial content of causes of senescence and is to see through the appearance to perceive the essence, be conceived to the slowly biochemistry development of development of animal body, be conceived to contain the biological side reaction process of general character, be conceived to the important of the manufacturing of quotidian daily biologic garbage and cleaning work thereof.
Carbonyl poisons the marrow that the nervous causes of senescence of oxidation is arranged in the causes of senescence, and the main idea of glycosylation causes of senescence is also arranged; The core process that has age pigment to form also has the main contents of crosslinked causes of senescence; Related to the aging control of sequencing that genetic factor causes, hinted that also meals custom and nutrition are to aged influence; Can explain disease to aged acceleration, also take pains and explain the different of aging and disease.
Summary of the invention
Summary of the invention the object of the invention provides a kind of anti-apolexis composition that contains reparative factor that can act synergistically on human body on multi-level, multidigit point.
Raw material of the present invention is formed and the weight portion proportioning is:
33～500 parts of vitamin cs, 33～100 parts of procyanidins, 3.3～25 parts of rhodiosides,
Vitamin B
61～4 part, vitamin B
11～1.5 part, vitamin B
21～2 part,
5～15 parts in nicotinic acid, 50～100 parts of taurines, 16～50 parts of arginine,
16～50 parts of lysines, 16～50 parts of inositols, 8～17 parts of zinc salts, zinc salt is selected from zinc oxide, Fructus Citri Limoniae
Acid zinc or zinc gluconate.
Vitamin c can be replaced by the vitamin c sodium salt during raw material of the present invention was formed, and nicotinic acid can be replaced by nicotiamide, and lysine can be replaced by lysine hydrochloride.
In the production the above-mentioned raw material that meets national standard through assay is weighed, technology is carried out composite routinely in GMP and 100,000 grades of cleaning shops, or pulverize, through the equivalent solvent dilution, adding filler to composition total weight part again in raw material of the present invention is formed is 1000 parts, mix homogeneously can be made into tablet or capsule, and filler is selected from medical starch or lysine hydrochloride.All technology is carried out routinely.
In forming, raw material of the present invention adds adjuvant sweeting agent, acidic flavoring agent, correctives and deionized water again, through mixing to whole dissolvings, make the fruit-flavor type liquid beverage, perhaps filling CO 2 is made the cola type liquid beverage, and all technology is carried out routinely.Sweeting agent is selected from sucrose, glucose or fructose, and acidic flavoring agent is selected from citric acid, lactic acid or phosphoric acid, and correctives is selected from ethyl maltol or Mel, and wherein the procyanidin consumption is reduced to 11～50 parts, rhodioside consumption and is reduced to 1.1～12.5 parts.
In forming, raw material of the present invention adds dietary fiber and adjuvant sweeting agent, acidic flavoring agent, correctives again, make solid beverage, sweeting agent is selected from sucrose, glucose or fructose, acidic flavoring agent is selected from citric acid, lactic acid or phosphoric acid, correctives is selected from ethyl maltol or Mel, and wherein the procyanidin consumption is reduced to 11～50 parts, rhodioside consumption and is reduced to 1.1～12.5 parts.
Procyanidin and rhodioside are bought from Xi'an sharp source bio tech ltd in the raw material of the present invention, and procyanidin derives from Semen Vitis viniferae extract, and content is greater than 95%.Rhodioside derives from Radix Rhodiolae extract, and content is greater than 4%, as buying the then natural Vc of composite, the VB of rhodioside
6Inadequately, need add Vc, VB in addition
6To ormal weight.
General character-carbonyl the ammonia that the present invention is directed to free radical theory and nonenzymatic glycosylation theory poisons, from antioxidation, anti-stress, in existing nutrient and effective component, searching is the material that the anti-again carbonyl ammonia of antioxidation poisons, its sign is the general molecular of anti peroxidation of lipid thing (ALES) and anti-nonenzymatic glycosylation end-product (AGES), yet can reach this effect without any a kind of material, each material all has its specific biological effect.Can not be simply, address this problem partly, therefore should weigh the advantages and disadvantages from comprehensive, the multi-angle of threpsology, medical angle of human body; Emphasis, the normal operation of each organ of balance human body, tissue, cell are targetedly arranged.Promptly stop or prevent the generation and the development of paathogenic factor from the source, as be deficient in vitamin C and lysine, the mcg vitamin that lacks suitably replenished, as VB
1, VB
2, VB
6, strengthen energy metabolism, particularly fat and protein metabolism, improve absorption and the utilization of human body to nutrient substance.The immunity of enhancing body.Suppress the generation of brown pigment.
The present invention can act synergistically on human body on multi-level, multidigit point, organize the anti-apolexis composition that contains reparative factor of the full maintenance of each organ and correction from cellular and molecular level to each.
The present invention is according to the Human Physiology characteristic, emphasis arranged comprehensively, targetedly each component combined, the reparative factor of reorganization can be brought into play cooperative effect better, repair the vigor of each cell of human body, tissue and organ comprehensively, suppress the biologic garbage that metabolism produced, thereby reach antidotal effect.The prevention subhealth state.
The effect of each component of the present invention is as follows:
1. vitamin C (L-ascorbic acid)
Be early to find generally a kind of water soluble vitamins of use, its major physiological effect body shows at the biosynthesis that promotes Collagen material, help the healing of tissue injury, promote skeleton and dental growth, strengthen blood capillary intensity, avoid skeleton and tooth oozing phenomenon to occur, promote tyrosine and tryptophan metabolism, quicken the metabolism of the dehydrogenation base of albumen or peptide class, the metabolism of influence fat and lipoid improves ferrum, the utilization of calcium and folic acid, it is a kind of important free radical scavenger, enhancing body is the stress ability of environment to external world, human body immunity improving power, antitumor.Ascorbic antitumor mechanism mainly comprises: can human body immunity improving power, promote lymphocytic formation; Can remove free radical, protection life macromolecule especially DNA is avoided the free radical infringement, thereby prevents cell carcinogenesis; Can suppress nitrite transforms to strong carcinogen inferior ammonium nitrate; Can promote Collagen material generation enhancing body tissue robustness and to the resistance of tumor cell, assist body to produce a kind of physiological hyaluronidase inhibitor, prevent the release of hyaluronidase, enhancing body antineoplastic ability.Vitamin C is non-specific to be made virally inactivatedly, suppresses the carcinogenesis of virus.Also can improve adenosine cyclophosphate (C-AMP) content in the cell, prevent cell carcinogenesis, can also promote the activate the phagocytic capacity of the synthetic and endoplasmic reticulum system of interferon (IL-2), the enhancing body anti-virus ability is to carcinogenic resistant function of virus.Because the vitamin C human body can not oneself synthesize and its character is very unstable, meets the metal easy oxidized destructions of catalysis such as (ferrum, copper ions), at the above alkaline environment of PH7.6, easy oxidized decomposition, but more stable under acid condition.
In the higher plant, as far as is known have at least 5 kinds of enzyme systems the ascorbic oxidation of catalysis to destroy, but the polyphenol compound in the plant have protective effect to vitamin C, all has this effect as rutin, Quercetin and relevant flavone.They can not only make the vitamin C in the food stable, and can be in intestinal, particularly do not have the ascorbic effect of playing stably in gastric acid or low gastric acid intestinal patient's the intestinal.Ascorbic clinical practice:
(1). arteriosclerosis a) prevents arteriosclerotic generation, and hypovitaminosis C not only damages blood capillary, and large artery trunks is also had infringement, and the long-term vitamin C that continues can not cause arteriosclerosis completely.Hypovitaminosis C can cause tremulous pulse inwall lipid calmness, and vitimin supplement C lipid disappears.Miasnikov investigates the long-lived person of Changshou village in addition, the ascorbic intake height of the crowd that arteriosclerosis is few.B) suppress arteriosclerotic risk factor, hyperlipemia is arteriosclerotic risk factor.Ascorbic content is lower mostly in hyperlipemia person's blood.The increase of cholesterol intake can make ascorbic requirement increase.The Ginter report, vitamin C and pectin are effective to the treatment hyperlipemia.Hypertension also is one of arteriosclerotic risk factor.Investigation shows that Vitamin C content is low in hyperpietic's blood.Ito gives the hypertensive rat of spontaneous generation with a large amount of vitamin Cs, can make its blood pressure drops.Russek report stressors is the promotion factor of arteriosclerosis maximum, and psychentonia can promote vitamin C to decompose, and makes vitamin C decline in the blood.
(2). inflammation: the vitamin C inflammation-inhibiting mainly is the antioxidation by it.Andeson thinks that the antiphlogistic basis of vitamin C is to suppress leukocytic myeloperoxidase (MPO), improves leukocytic mobility.Vitamin C also is not very clear at present to the mechanism of action of peroxidase, but has report to think, vitamin C is the effect that the catalase (catalase) that suppresses antibacterial is arranged.Give Catergen 00mg every day, can make the content of C-AMP in the leukocyte (adenosine cyclophosphate) recover normal, leukocytic motor capacity is recovered, reduce the outbreak of infecting.The increase of B-cells ratio, T-cell that hypovitaminosis C presented are reduced phenomenon, give vitamin C and can recover normal.The relation of vitamin C and humoral immunization is still not fully aware of, but to the increase of bronchial asthma patient IgE (IgE) and the reduction of leukocyte movability, gives vitamin C 1g every day, can make it to improve.
(3). the ascorbic consumption of cancer cancer patient increases, and similar scorbutic symptom often occurs.Many reports point out that vitamin C has inhibitory action to the kinds of experiments tumor.Fields, village etc. give (average 25g) vitamin C more than the patient with advanced cancer 5g/d, average life significant prolongation through vein.It is generally acknowledged by following several approach about ascorbic antitumaous effect: (1) makes hyaluronidase (hyaluronidase) loss of activity of cancerous tissue, suppresses the increase of connective tissue, suppresses the growth of cancer.(2) by making adenyl cyclase (adenylcyclase) loss of activity, suppress phosphodiesterase (phosphodiesterase), thereby suppress to increase the growth of the cancer of bringing out by C-AMP in the tissue.
Procyanidin (Ogligomeric Proanthocyanidins, OPC):
Be the most effective natural anti-oxidation material, extract from Semen Vitis viniferae, Cortex Pini etc. that main content can reach more than 95%, is Flavonoid substances, has very strong removing free radical, functions such as antioxidation can be prevented more than the 70 kind disease relevant with free radical.Integrated following characteristics:
(1) can help all systems of health to run well;
(2) can pass through blood brain barrier;
(3) be known stronger antioxidant, it is all stronger than vitamin E and ascorbic oxidation resistance;
(4) bioavailability is relatively good, can reach 85%;
(5) be water miscible, facts have proved simultaneously what side effect it does not have, use as safe as a house;
(6) can protect vitamin C, make vitamin C unlikely degraded when taking, and retention time be longer in vivo;
(7) be by the flavone monomer, the complex that binary and oligomer are formed, so its interaction energy in vivo keeps long period 3-8d.
Because the polyunsaturated fatty acid ratio is very high among the central nervous system, oxygen content will account for 20% of whole body oxygen content in brain, and therefore, the central nervous system is easy oxidation, the easiest place of being attacked by free radical.A lot of nervous system diseasies all cause owing to lipid peroxidation.In antioxidant, majority can not pass through blood brain barrier, thus OPC can neuroprotective cell membrane, make these cells can homergy, the protection brain.Secondly vitamin C has the effect of protection vitamin E, and when vitamin C existed, vitamin E was not consumed, and therefore by OPC protection vitamin C, vitamin C reduction vitamin E is at last by vitamin E performance antioxidation.Simultaneously vitamin C can the reduction-oxidation glutathione, improves the activity of glutathione transferase.Also can oxygen reduction voltinism hemoglobin, improve the oxygen carrying capacity of hemoglobin.
Flavonoid is phenols or polyphenol compound, be the chelate and the free radical scavenging thing of in-vivo metal, simultaneously can also help human body to ascorbic absorption, biological flavone can influence most of enzyme systems in the body, as protein kinase, and tyrosine kinase, Cytochrome P450, glutathione transferases etc., these enzymes are to the disease of human body, and particularly chronic degenerative disorders and tumor play a crucial role.Biological flavone can play a driving role to the generation of secretory action and neurotransmitter in addition, to lipid peroxidation, antigenic generation, platelet aggregation with adhere at the blood vessel periosteum, malignant cell breed prevention and interference effect.
This super " protectiveness " nutrient is concluded following health care: a) can prevent and reduce the heart and brain disease, cancer, age ageing, response to oxidative stress, more than 70 kinds and the danger free radical diseases associated.B) structure and the intensity of reinforcement blood vessel.C) song and the rigidity of increase erythrocyte membrane.D) promote skin health.E) control anaphylaxis.F) prevent and treat inflammation.G) alleviate the retinopathy that diabetes cause.H) raise immunity.J) eye health.K) control gastroenteropathy.
According to another 2005 01 phases " Chinese geriatrics magazine " publications " grape seed polyphenols anti-diabetic rat nonenzymatic glycosylation experimentation " civilian conclusion: result and the comparison of blank group, grape seed polyphenols (GSPE) can significantly reduce the heavy body weight ratio (P ∠ 0.01) of diabetes rat kidney, reduce renal cortex nonenzymatic glycosylation end-product (AGES P ∠ 0.01), in the grape seed polyphenols (GSPE), high dose group is similar to the effect of aminoguanidine treatment group, grape seed polyphenols (GSPE) is to blood glucose, triglyceride (TG) does not make significant difference, only dosage group T-CHOL (TC) has significance (P ∠ 0.01) with normal control group comparing difference in the grape seed polyphenols (GSPE), and conclusion grape seed polyphenols (GSPE) can suppress non-enzymatic glycation (NEG) in the body.That is to say that grape seed polyphenols (GSPE) can suppress non-enzymatic glycation in the body, reduce renal cortex nonenzymatic glycosylation end-product (AGES), just reduced the poisoning effect of nonenzymatic glycosylation end-product (AGES), have antidotal effect human body.
3. rhodioside
Rhodioside is the extract of Radix Rhodiolae.Have the comprehensive opsonic action of human body.
Feeble QI perfume (or spice), bitter in the mouth, puckery, cold; Heat-clearing and toxic substances removing, dampness are used for lung-heat, arteries and veins heat, pestilence, limb edema.Tibetan medicine record: invigorate blood circulation, stop blooding, regulate the flow of vital energy nourish blood, strengthening the body resistance, nourishing the brain and improving intelligence, nourishing and fit keeping function.
Through medical expert's physico-chemical analysis and Instrumental Analysis both at home and abroad, kind of chemical compound surplus Radix Rhodiolae contains 40, mainly contain glycoside (rhodioloside, Arbutin, Lu Ding glycoside etc.), flavonoid (Quercetin, kaempferol anthocyanin etc.), Coumarins, amino acids, microelement kind and other class chemical constituents, modern medicine study is pointed out: Radix Rhodiolae is the environmental suitability medicine, adapt to the former state medicine, be used for receiving on military medicine, aerospace medicine, the sports medical science better curative effect.Its critical function has: anti-hypoxia, resisting fatigue, the two-ways regulation to nervus centralis, delaying senility function, antitoxic action, radiation resistance and protective effect on cancer risk, to dual regulation of hormonal system etc.
Have the effect of similar Radix Ginseng and do not have the scorching of Radix Ginseng, can obviously improve anaerobic condition, improve superoxide dismutase (SOD) activity, increase glutathion (GSH) content, remove free radical, remove lipid peroxide (LPO), particularly rhodioside has macrophage in the human body of raising, the NK cell, the lymphocytic activity of T, and can make 5-hydroxy tryptamine (5-HT) recover normal rapidly.
4. vitamin B
6
Vitamin B
6Comprise pyridoxol, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine., three kinds of pyridoxamines, these three kinds can transform mutually in vivo through enzyme.It mainly is to participate in many metabolic responses as coenzyme, comprises protein, and the metabolism of fat and carbohydrate wherein the most important thing is protein metabolism.Vitamin B
6Be requisite important substance such as the generation of energy, aminoacid and lipid metabolism, central nervous system's activity and hemoglobin production.Say that according to another " life science " record pyridoxamine is a kind of natural AGES/ALES inhibitor,, thereby suppress the generation of AGES/ALES because it can directly remove carbonyl complex.Because vitamin B
6Closely related with proteinic metabolism, so along with the increase of proteinic absorption, vitamin B
6Requirement also increase the therefore deficiency that just shows of the vitamin B6 that from food, obtains gradually.Vitamin B
6Side effect to human body is very little, and pyridoxol is in the immunity of tumor with prevent from also to play an important role aspect the arteriosclerosis in addition.It can suppress the formation of biochemical poisonous substance homocysteine, and this poisonous substance can make cholesterol deposits on cardiac muscle, attacks heart.So vitamin B
6These functions its tool aspect defying age is played a very important role.
5. vitamin B
1(thiamine)
Vitamin B
1The metabolism of involved in sugar promotes energy metabolism, safeguards normal function neural and digestive system, promotes growth promoter.
6. vitamin B
2(riboflavin)
Vitamin B
2In the oxidizing process of body biology, work the hydrogen effect of passing, essential by the metabolism of carbohydrate, aminoacid and fatty acid, still be the coenzyme of many oxidase systems.
7. nicotinic acid (claiming nicotinic acid again)
Nicotinic acid and nicotiamide are the derivant of pyridine, and they have identical nicotinic acid biological activity in vivo.Nicotinic acid mainly occurs with nicotinamide adenine dinucleotide (NAD) and these two kinds of forms of nicotinamide-adenine dinucleotide phosphate (NADP) in vivo, and they are two kinds of important nadide, coenzyme II.The main effect of nicotinic acid is the constituent as these two kinds of important coenzyme, participates in carbohydrate, fat and proteinic metabolism.NAD and NADP are indispensable hydrogen carriers in the biological oxidation process, are the initial transmitter of electron transport system.
8. taurine (2-aminoethyl sulfonic acid)
Taurine is a kind of conditionality essential amino acids.Daily various foods; comprise that corn, fruits and vegetables etc. do not contain taurine; though human body can synthesize; but seriously stress state or the situation of some disease under; lack easily, have influence on growth, vision, heart and brain, taurine can the liver protecting be avoided the damage of free radical; promote the generation of cholate, the absorption of fat is worked well.In cerebral tissue, contain abundant taurine, spinal neuron is had very strong inhibitory action.It is important anti-stress medicine.
9. arginine (L-Arginine)
Arginine is a constituent in the ornithine cycle, has extremely important physiological function.Can increase the activity of arginase in the liver (arginase), reduce blood ammonia, keep positive nitrogen balance.Also can promote the synthetic of collagen tissue.
Arginine participates in the biosynthesis of other aminoacid, peptide (as playing thymosin, Thymopentin and the tuftsin of important immunization) and protein (as histone).In addition, arginine also is the unique amino source of synthesis material glucocyamine of anakinetomer phosphagen.By the ornithine conversion, arginine is synthetic second material of polyamines.Nearest discovers, the arginine conversion generates citrulline and nitric oxide (NO), wherein NO is a kind of molecular effect device and the neurotransmitter of recent findings, simultaneously, arginine also is a kind of potential endocrine secretagogues matter, can promote the growth of thymus medium-sized lymphocyte, prevent involution of thymus, make body obtain enough immunity.
10. lysine
Lysine is alkaline essential amino acids.Because lysine content is very low in the corn, food, and easily destroyed and lack in the course of processing, so title first limiting amino acid.Can stimulate the secretion of pepsin and gastric acid, appetite stimulator promotes the absorption of calcium, keep the positive balance of nitrogen, also can help to produce antibody, hormone and enzyme, and relevant with the reparation of the formation of collagen, tissue, also can reduce the level of triglyceride in the blood, can also prevent and treat herpes simplex virus.
11. inositol
Be cyclohexanhexanol, fat is had affinity, can promote body to produce lecithin, thereby help, reduce the sickness rate of fatty liver in the liver fat transporte to cells.Also can promote lipid metabolism, cholesterol reducing.By with choline binding, inositol can prevent fatty arteriosclerosis, and the protection heart.It also is the precursor substance of phosphoinositide.Phospholipid is to constitute biomembranous important composition composition, can promote nerve conduction, improves the brain vigor.
12. zinc
Zinc is the constituent of multiple metalloenzyme in the body.Can protect and the stabilate film, can promote the growth promoter and the tissue regeneration of body, regulate immunologic function, influence hormonal system, improve the sense of taste and promote appetite.Promote the homergy and the visual performance of vitamin A.The normal function of protection skin and skeleton promotes intelligence development.
Antioxidation test of the present invention is as follows: MDA content is measured in zoopery, and (MDA is one of snperoxiaized end-product of cell membrane lipid.)
1 material.
1.1 medicine and reagent
Reparative factor: self-control product; Thiobarbituricacid (TBA): Shanghai reagent two factory's products; Alloxan, Shanghai reagent two factory's products.
1.2 animal
Kunming mouse, the male and female dual-purpose, children Mus in age (18-20g) and 12 the monthly age Mus.The SD rat, male and female dual-purpose, 5-6 Mus in age in week.Above-mentioned animal is provided by Lanzhou animal and veterinary institute.
1.3 instrument
721 spectrophotometers: Shanghai the 3rd analytical tool factory.
2 methods
2.1 alloxan causes mouse brain lipid peroxide elevation model
Kunming mouse 18-22g in administration 0.5h disposable vein injection alloxan 75mg/kg after the 7th day, continues administration 5d, puts to death mice, gets full brain, measures the wherein content of MDA.
2.2 hydrogen peroxide causes rat cerebral even slurry lipid peroxide elevation model
Get 3 of SD rats, broken end is got brain, ice-cold phosphate buffer solution flush away bloodstain, and make 10% homogenate with the phosphate buffer solution of pH 7.4, add the self-control product earlier, back adding H
2O
2, final concentration is 25mmoL/L, 37 ℃ of incubation 1h put into ice bath 10Min cessation reaction after the taking-up, measure the wherein content of MDA.
2.3 hydroxy radical causes rat cerebral even slurry lipid peroxide elevation model
Get 3 of SD rats, broken end is got brain, ice-cold phosphate buffer solution flush away bloodstain, and make 10% homogenate with the phosphate buffer solution of pH 7.4.Add the self-control product earlier, the back adds FeSO
4And H
2O
2(final concentration is 0.15mmol/L).37 ℃ of incubation 0.5h put into ice bath 10Min cessation reaction, measure the wherein content of MDA.
2.4 organize malonaldehyde (MDA) content assaying method
Tissue is made 10% homogenate with the phosphate buffer solution of 0.05mmol/L pH 7.4, get 0.1mL homogenate, hac buffer 1.5mL, the 1%TBA 1.5mL, the distilled water 1.0mL that add 8.1%SDS 0.2mL, pH 3.5 successively, boiling water bath 40min, the centrifugal 15min of cooling back 3000rpm gets supernatant and surveys the OD value in 532nm wavelength place.Be calculated as follows every gram and organize the growing amount of MDA: concentration (nmoL/g tissue)=OD15/10 * 4.3/ (1.56 * 0.01)
2.5 date processing
The test data average; (x ± s) expression is with t check carrying out statistical analysis between group for standard deviation
3 results
3.1 the influence that reparative factor raises to rat cerebral even slurry MDA content due to the hydrogen peroxide
As shown in Table 1, H
2O
2(25mmol/L) make the content of MDA in the brain homogenate (P﹠amp that raises extremely significantly; Lt; 0.01), and using reparative factor 3.5,10mg.kg all can extremely significantly reduce the content of MDA, and tangible dose dependent is arranged.Prompting self-control product can resist H
2O
2The cerebral tissue lipid peroxidation injury that causes.
3.2 the influence that reparative factor raises to rat cerebral even slurry MDA content due to the hydroxy radical
As shown in Table 2, FeSO
4And H
2O
2The OH that (final concentration is 0.15mmol/L) reaction generates can extremely significantly increase the content (P﹠amp of MDA in the brain homogenate; Lt; 0.01), and using reparative factor 3.5,10mg.kg all can extremely significantly reduce the content of MDA and have tangible dose dependent.Prompting self-control product can resist the cerebral tissue lipid peroxidation injury that OH causes.
3.3 the influence that reparative factor raises to alloxan induced mice cerebral tissue MDA content
By table 3 as seen, alloxan 75mg/kg can significantly increase MDA content (P﹠amp in the mouse brain; Lt; 0.05), and reparative factor 3.5,10mg.kg, ip 7d) all can significantly suppress the rising (P﹠amp of MDA content; Lt; 0.01), thereby play the effect that protection cerebral tissue lipid is avoided peroxide injury.
3.4 reparative factor is to the influence of 12 monthly age Mouse Liver, cerebral tissue MDA content
Male 12 the monthly age 30 of mices, be divided into blank group, reparative factor high dose group, reparative factor low dose group at random, 10/organize.Dosage is as shown in table 4.Every day, 16:00-18:00 SC in totally 2 weeks, in the sacrificed by decapitation mice next day of last administration, got each about 200mg of liver and brain, measured the wherein content of MDA.The result shows reparative factor, 3.5, and 10mg/kg, SC 2W) all can reduce liver, cerebral tissue MDA content extremely significantly.Show that reparative factor can protect mice liver cerebral tissue lipid in the usual aging process to avoid snperoxiaized damage, thus the antagonism body aging.
Compare with matched group
##P ∠ 0.01 compares with the hydrogen peroxide matched group
*P ∠ 0.01
Compare with matched group
##P ∠ 0.01 compares with the hydroxy radical matched group
*P ∠ 0.01
Compare with matched group
##P ∠ 0.05 compares with the alloxan matched group
*P ∠ 0.01
Compare with matched group
*P ∠ 0.01
The above results is measured by Biology Department of Lanzhou Univ.'s Animal Lab.
Test-meal experiment of the present invention
1. test-meal method is selected 10 people by the principle of voluntariness, age 40-60 year, and male 7 people wherein, women 3 people, 1 of day clothes, take half an hour before sleeping every night.
2. after the test-meal analysis serve on February, measure blood sample next day, table 5 blood routine examination shows: T-CHOL, triglyceride, low density lipoprotein, LDL Gao Zhejun have reduction in various degree, and up 21.3%, especially T-CHOL reduce the most obvious.The low person of high density lipoprotein all has rising in various degree, and the normal person of index does not have significant change.Subjective sensation fatigue alleviates, and is dynamic, and brain is clear, resourceful, and sense of discomfort alleviates, and the sleep quality enhancer reaches 90%.
The above results is measured by silver Gan Bao hospital.
The specific embodiment
The following examples can make those skilled in the art more fully understand the present invention, but do not limit the present invention in any way.
Embodiment 1 gets vitamin c 33 grams, procyanidin (sharp source, Xi'an bio tech ltd) 33 grams, rhodioside (sharp source, Xi'an bio tech ltd) 3.3 grams, vitamin B
61 gram, vitamin B
11 gram, vitamin B
21 gram, nicotinic acid 5 grams, taurine 50 grams, arginine 16 grams, lysine 16 grams, inositol 16 grams, zinc oxide 8 grams.Above-mentioned raw materials is pulverized, crossed 60～80 mesh sieves, add filler to 1000 gram, filler is selected from medical starch or lysine hydrochloride, mix homogeneously then, pelletize, machine-processed tabletting.
Embodiment 2 gets vitamin c 500 grams, procyanidin (sharp source, Xi'an bio tech ltd) 100 grams, rhodioside (sharp source, Xi'an bio tech ltd) 25 grams, vitamin B
64 grams, vitamin B
11.5 gram, vitamin B
22 grams, nicotinic acid 15 grams, taurine 100 grams, arginine 50 grams, lysine 50 grams, inositol 50 grams, zinc oxide 17 grams.Above-mentioned raw materials is pulverized, crossed 60～80 mesh sieves, add filler to 1000 gram, filler is selected from medical starch or lysine hydrochloride, mix homogeneously then, mechanism dress capsule.
Embodiment 3 gets vitamin c 200 grams, procyanidin (sharp source, Xi'an bio tech ltd) 50 grams, rhodioside (sharp source, Xi'an bio tech ltd) 10 grams, vitamin B
62 grams, vitamin B
11.3 gram, vitamin B
21.5 gram, nicotinic acid 10 grams, taurine 63 grams, arginine 33 grams, lysine 33 grams, inositol 33 grams, zinc oxide 12 grams.Above-mentioned raw materials is pulverized, crossed 60～80 mesh sieves, add filler to 1000 gram, filler is selected from medical starch or lysine hydrochloride, mix homogeneously then, mechanism dress capsule.
Embodiment 4 gets vitamin c 300 grams, procyanidin (sharp source, Xi'an bio tech ltd) 40 grams, rhodioside (sharp source, Xi'an bio tech ltd) 11 grams, vitamin B
62 grams, vitamin B
11 gram, vitamin B
21 gram, nicotiamide 15 grams, taurine 63 grams, arginine 33 grams, lysine hydrochloride 50 grams, inositol 33 grams, zinc oxide 10 grams.Above-mentioned raw materials is pulverized, crossed 60～80 mesh sieves, add filler to 1000 gram, filler is selected from medical starch or lysine hydrochloride, mix homogeneously then, mechanism dress capsule.
Embodiment 5 gets vitamin c sodium salt 500 grams, procyanidin (sharp source, Xi'an bio tech ltd) 60 grams, rhodioside (sharp source, Xi'an bio tech ltd) 15 grams, vitamin B
61 gram, vitamin B
11 gram, vitamin B
21 gram, nicotinic acid 10 grams, taurine 63 grams, arginine 50 grams, lysine hydrochloric acid 16 grams, inositol 33 grams, zinc oxide 10 grams.Above-mentioned raw materials is pulverized, crossed 60～80 mesh sieves, add filler to 1000 gram, filler is selected from medical starch or lysine hydrochloride, mix homogeneously then, mechanism dress capsule.
Embodiment 6 gets vitamin c sodium salt 200 grams, procyanidin (sharp source, Xi'an bio tech ltd) 70 grams, rhodioside (sharp source, Xi'an bio tech ltd) 7 grams, vitamin B
62 grams, vitamin B
11.3 gram, vitamin B
21.5 gram, nicotiamide 10 grams, taurine 63 grams, arginine 33 grams, lysine hydrochloride 33 grams, inositol 33 grams, zinc gluconate 10 grams.Above-mentioned raw materials is pulverized, crossed 60～80 mesh sieves, add filler to 1000 gram, filler is selected from medical starch or lysine hydrochloride, mix homogeneously then, mechanism dress capsule.
Embodiment 7 gets vitamin C 40 grams, procyanidin 10 grams, rhodioside 20 grams, vitamin B
61 gram, vitamin B
11 gram, vitamin B
21 gram, nicotinic acid 10 grams, taurine 50 grams, arginase 12 0 gram, lysine 20 grams, inositol 20 grams, zinc citrate 8 grams.Above-mentioned raw materials is added pure water, citric acid 180 grams, ethyl maltol 10 grams are stirred to whole dissolvings.Sucrose 8000 grams are added pure water, join again in the above-mentioned solution after the roguing of heating disinfection sterilising filtration, add pure water, stir to 100L, check, packing gets final product.
Embodiment 8 gets vitamin C 50 grams, procyanidin 10 grams, rhodioside 10 grams, vitamin B
61 gram, vitamin B
11 gram, vitamin B
21 gram, nicotinic acid 10 grams, taurine 50 grams, arginase 12 0 gram, lysine 20 grams, inositol 20 grams, zinc citrate 8 grams.Above-mentioned raw materials is added pure water, citric acid 180 grams, ethyl maltol 10 grams are stirred to whole dissolvings.Sucrose 8000 grams are added pure water, join in the above-mentioned solution after the roguing of heating disinfection sterilising filtration again, add pure water to 100L, stir, check charges into the carbon dioxide bottling, makes cola beverages.
Embodiment 9 gets vitamin C 50 grams, procyanidin 10 grams, rhodioside 20 grams, vitamin B
61 gram, vitamin B
11 gram, vitamin B
21 gram, nicotinic acid 10 grams, taurine 50 grams, arginase 12 0 gram, lysine 20 grams, inositol 20 grams, zinc citrate 8 grams.Above-mentioned raw materials is added dietary fiber 5000 grams, sucrose 8000 grams, citric acid 180 grams, ethyl maltol 10 grams, mix homogeneously, solid beverage is made in check.
Claims (7)
1. an anti-apolexis composition that contains reparative factor is characterized in that raw material is formed and the weight portion proportioning is: 33～500 parts of vitamin cs, 33～100 parts of procyanidins, 3.3～25 parts of rhodiosides, vitamin B
61～4 part, vitamin B
11～1.5 part, vitamin B
28～17 parts of 1～2 part, 5～15 parts in nicotinic acid, 50～100 parts of taurines, 16～50 parts of arginine, 16～50 parts of lysines, 16～50 parts of inositols and zinc salts, zinc salt is selected from zinc oxide, zinc citrate or zinc gluconate.
2. the anti-apolexis composition that contains reparative factor according to claim 1 is characterized in that: vitamin c was replaced by the vitamin c sodium salt during the described raw material of claim 1 was formed, and nicotinic acid is replaced by nicotiamide, and lysine is replaced by lysine hydrochloride.
3. anti-apolexis composition that contains reparative factor is characterized in that: adding filler to composition total weight part again in the described raw material of claim 1 is formed is 1000 parts, and filler is selected from medical starch or lysine hydrochloride, makes tablet.
4. anti-apolexis composition that contains reparative factor is characterized in that: adding filler to composition total weight part again in the described raw material of claim 1 is formed is 1000 parts, and filler is selected from medical starch or lysine hydrochloride, makes capsule.
5. anti-apolexis composition that contains reparative factor, it is characterized in that: in the described raw material of claim 1 is formed, add adjuvant sweeting agent, acidic flavoring agent, correctives and deionized water again, make liquid beverage, sweeting agent is selected from sucrose, glucose or fructose, acidic flavoring agent is selected from citric acid, lactic acid or phosphoric acid, correctives is selected from ethyl maltol or Mel, and wherein the procyanidin consumption is reduced to 11～50 parts, rhodioside consumption and is reduced to 1.1～12.5 parts.
6. anti-apolexis composition that contains reparative factor, it is characterized in that: in the described raw material of claim 1 is formed, add adjuvant sweeting agent, acidic flavoring agent, correctives, carbon dioxide and deionized water again, make the cola type liquid beverage, sweeting agent is selected from sucrose, glucose or fructose, acidic flavoring agent is selected from citric acid, lactic acid or phosphoric acid, correctives is selected from ethyl maltol or Mel, and wherein the procyanidin consumption is reduced to 11～50 parts, rhodioside consumption and is reduced to 1.1～12.5 parts.
7. anti-apolexis composition that contains reparative factor, it is characterized in that: in the described raw material of claim 1 is formed, add dietary fiber and adjuvant sweeting agent, acidic flavoring agent, correctives again, make solid beverage, sweeting agent is selected from sucrose, glucose or fructose, acidic flavoring agent is selected from citric acid, lactic acid or phosphoric acid, correctives is selected from ethyl maltol or Mel, and wherein the procyanidin consumption is reduced to 11～50 parts, rhodioside consumption and is reduced to 1.1～12.5 parts.
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| CN101822401B (en) * | 2010-01-26 | 2013-04-03 | 斯必利药业(厦门)有限公司 | Beverage with function of alleviating fatigue |
| CN102309007B (en) * | 2011-09-26 | 2013-11-06 | 中国人民解放军空军航空医学研究所 | Dietary supplement and preparation method thereof |
| CN102793243B (en) * | 2012-08-15 | 2013-11-27 | 广州白云山潘高寿药业股份有限公司 | Beverage for sub-health conditioning and its preparation method |
| CN105475999A (en) * | 2015-11-27 | 2016-04-13 | 杭州海王生物工程有限公司 | Composition with effects of resisting oxidation, improving liver damage and improving immunity |
| CN107936065A (en) * | 2017-12-12 | 2018-04-20 | 浙江农林大学 | A kind of application of rhodioside of method and synthesis based on Microwave-assisted synthesis rhodioside on anti-senile preparation |
| CN109350623A (en) * | 2018-05-25 | 2019-02-19 | 泓博元生命科技（深圳）有限公司 | Anti-apolexis composition and its preparation and preparation method and application comprising NADH and ceramide |
| JP2020200298A (en) * | 2019-06-13 | 2020-12-17 | 株式会社再春館製薬所 | Skin external preparation |
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