KR20040035320A - A composition of nanosphere comprising propolis and tocopherol - Google Patents
A composition of nanosphere comprising propolis and tocopherol Download PDFInfo
- Publication number
- KR20040035320A KR20040035320A KR1020020064416A KR20020064416A KR20040035320A KR 20040035320 A KR20040035320 A KR 20040035320A KR 1020020064416 A KR1020020064416 A KR 1020020064416A KR 20020064416 A KR20020064416 A KR 20020064416A KR 20040035320 A KR20040035320 A KR 20040035320A
- Authority
- KR
- South Korea
- Prior art keywords
- weight
- tocopherol
- propolis
- nanosphere
- nanospheres
- Prior art date
Links
- 239000002077 nanosphere Substances 0.000 title claims abstract description 42
- 241000241413 Propolis Species 0.000 title claims abstract description 30
- 229940069949 propolis Drugs 0.000 title claims abstract description 30
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 229930003799 tocopherol Natural products 0.000 title claims abstract description 27
- 239000011732 tocopherol Substances 0.000 title claims abstract description 27
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title claims abstract description 27
- 235000010384 tocopherol Nutrition 0.000 title claims abstract description 25
- 229960001295 tocopherol Drugs 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000008213 purified water Substances 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000000606 toothpaste Substances 0.000 claims abstract description 10
- 229940034610 toothpaste Drugs 0.000 claims abstract description 10
- 239000002537 cosmetic Substances 0.000 claims abstract description 6
- 235000013305 food Nutrition 0.000 claims abstract description 6
- 150000003611 tocopherol derivatives Chemical class 0.000 claims abstract description 6
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 5
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 claims abstract description 5
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims abstract description 5
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims abstract description 4
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 abstract description 7
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- 230000000087 stabilizing effect Effects 0.000 abstract description 2
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- 238000002360 preparation method Methods 0.000 description 10
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- -1 aromatic alcohols Chemical class 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
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- DFUSDJMZWQVQSF-XLGIIRLISA-N (2r)-2-methyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 DFUSDJMZWQVQSF-XLGIIRLISA-N 0.000 description 3
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- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/0241—Containing particulates characterized by their shape and/or structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/20—Ingredients acting on or related to the structure
- A23V2200/25—Nanoparticles, nanostructures
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/18—Lipids
- A23V2250/184—Emulsifier
- A23V2250/1842—Lecithin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/70—Vitamins
- A23V2250/712—Vitamin E
Abstract
Description
본 발명은 프로폴리스와 토코페롤을 함유하는 나노스피어 조성물에 관한 것으로, 더욱 상세하게는 변색이 심한 프로폴리스와 피부나 잇몸, 체내에 흡수되는 속도가 낮아서 생체이용률이 적은 토코페롤을 나노스피어를 형성하여 안정화시켜서 식품, 화장품, 생활용품 등의 분야에서 다양하게 이용할 수 있도록 하는 프로폴리스와 토코페롤을 함유하는 나노스피어 조성물에 관한 것이다.The present invention relates to a nanosphere composition containing propolis and tocopherol, and more particularly, to stabilize the discoloration of tocopherol with low bioavailability due to the low rate of absorption into the propolis and skin, gums, and body which are highly discolored. The present invention relates to a nanosphere composition containing propolis and tocopherol, which can be used in various fields such as food, cosmetics, and household goods.
계면활성제는 물에 용해되어 미셸(micelle)을 형성한다. 그러나, 인지질과 같이 친유 부분이 2개인 분자는 평면상으로 볼 때 직사각형을 이루고 이것은 물에 분산시켰을 때 구상이 아닌 2분자막(Bilayer)를 형성하는데, 이러한 폐쇄 소포체를 리포좀이라 하는데 대하여 모노레이어를 형성하는 것은 나노스피어(nanosphere)라한다(도 1).The surfactant is dissolved in water to form a micelle. However, molecules with two lipophilic moieties, such as phospholipids, form a rectangle in plan view, which, when dispersed in water, form a bilayer that is not spherical. The closed vesicles are called liposomes. Formation is called nanospheres (FIG. 1).
나노스피어는 유상의 활성 물질 포집에 이용하는데 나노스피어는 안정성, 유변학적 특성, 균일성, 높은 계면 면적 등 기존의 일반 에멀젼과는 다른 물리화학적 특성을 지닌다. 즉, 나노스피어는 내부에 난용성 생리 활성물질(예를 들면, 프로폴리스, 토코페롤 등)이나 낮은 생체이용률을 가진 물질을 함유하여 생체이용률을 증진시킴으로써 제품을 통해 생리 활성물질을 선택적으로 피부와 입 안의 점막, 잇몸에 빠르게 흡수되도록 하여 그 효과를 증대시키는 작용을 한다.Nanospheres are used to collect active materials in oily phase. Nanospheres have different physicochemical properties from conventional emulsions such as stability, rheological properties, uniformity and high interface area. In other words, nanospheres contain poorly soluble bioactive substances (for example, propolis, tocopherol, etc.) or materials with low bioavailability, thereby enhancing bioavailability to selectively select bioactive substances through skin and mouth. The mucous membrane of the inside, so that the gum is quickly absorbed to increase the effect.
최근에는 상기한 바와 같은 특성을 가지는 나노스피어를 이용하여 난용성 물질을 안정화하려는 연구가 많이 진행되고 있고 특허출원도 늘어나고 있는 추세이다.Recently, many studies have been conducted to stabilize poorly soluble materials using nanospheres having the above characteristics, and patent applications are increasing.
프로폴리스(propolis)는 본래 희랍어의 프로(pro, 전)와 폴리스(polis, 도시)란 말에서 유래된 것으로, 벌집의 입구에서 발견되었기 때문에 붙여진 이름이며 벌집을 외부로부터 보호하고 방어한다는 의미를 지니고 있다. 꿀벌의 아교, 황색 꿀벌의 아교는 좋은 향기가 난다. 꿀벌집 입구에서 추출되며 그 성질은 밀랍과 유사하다. 이러한 프로폴리스는 꿀벌들이 벌집을 지을때 벌집 속의 벽에 칠해서 벌집 내부를 보강하고 벌집 속에 생기는 잡균을 살균하여 깨끗하게 하는 작용을 한다. 주성분은 지금까지 149가지의 화합물과 22가지의 미네랄이 함유되어 있는 것으로 밝혀졌는데, 이들 화합물 중 약 40 내지 50%는 수지 및 방향성 물질, 25 내지 35%는 밀랍, 10%의 휘발유 또는 정유, 5%의 꽃가루, 5%의 다양한 유기물과 미네랄(유기산류, 페놀산류, 방향족 알코올, 쿠마린류, 플라보노이드류, 비타민류, 효소등)로 이루어져 있다. 특히 이중에서 플라보노이드는 세포막을 강화하고 세포 작용을 활성화하며, 단백질의 일종인 콜라겐의 합성을 돕고, 결합조직이나 혈관, 피부 등을 튼튼히 하며, 활성 산소의 합성과 작용을 억제하고, 체내 산소나 발암 물질의 합성을 억제, 면역 기능을 높이고, 바이러스나 세균 등에 대한 저항력을 강화한다.Propolis was originally derived from the Greek words pro and polis, and was named because it was found at the entrance of a honeycomb, meaning it protects and defends the honeycomb from the outside. have. The glue of bees, the glue of yellow bees smells good. Extracted at the entrance of the honeycomb, its properties are similar to beeswax. When these bees build honeycombs, they act on the walls of the honeycomb to reinforce the interior of the honeycomb and to sterilize and cleanse the germs in the honeycomb. Its main ingredient has been found to contain 149 compounds and 22 minerals, of which about 40-50% are resins and aromatics, 25-35% beeswax, 10% gasoline or essential oils, 5 It is composed of% pollen, 5% organic matter and minerals (organic acids, phenolic acids, aromatic alcohols, coumarins, flavonoids, vitamins, enzymes, etc.). In particular, flavonoids strengthen cell membranes and activate cellular functions, help the synthesis of collagen, a type of protein, strengthen connective tissue, blood vessels, and skin, inhibit the synthesis and action of free radicals, and inhibit oxygen and carcinogenesis in the body. It inhibits the synthesis of substances, enhances immune function, and strengthens resistance to viruses and bacteria.
또한, 프로폴리스는 항균 작용, 염증 억제, 바이러스 증식 억제, 면역력 활성화, 피부병과 화상 등의 치료, 구강 악취 제거, 간 보호, 혈관 강화 작용, 혈관 정화 작용, 항산화 작용 등이 있다. 구강에서 치아 우식증을 유발하는 대표적인 구강 세균으로는Mutans streptococci, Lactobacilli, Actionmyces등이 있는데, 프로폴리스 추출물은 이들 세균이 구강 내에서 증식하는 것을 억제하고 구강의 악취를 제거한다.In addition, propolis has antibacterial action, inflammation inhibition, virus growth inhibition, immune power activation, skin disease and burn treatment, oral malodor removal, liver protection, vascular strengthening, vascular purification, antioxidant action and the like. Representative oral bacteria that cause dental caries in the oral cavity include Mutans streptococci, Lactobacilli and Actionmyces . Propolis extracts inhibit the growth of these bacteria in the oral cavity and remove oral odor.
토코페롤은 비타민 E라고도 하는데, 비타민 E의 작용이 있는 물질은 토콜(tocol), 즉 2-메틸-2-[트리메틸-트리데실]-6-히드록시크로만(2-methyl-2[tri- methyl-tridecyl]-6-hydroxychromane)을 기본 골격으로 하는 크로만 유도체이다. 토코페롤의 측쇄는 피토올(phytol)로부터 유래되어 있고 측쇄의 3', 7', 11' 위치에 이중결합을 갖는 트리에놀은 토콜과 비슷한 구조를 가지고 있다. 토콜과 트리에놀은 크로만 고리에 메틸기의 위치와 수에 의해 여러가지 이성질체가 된다. 토코페롤 종류에는 알파, 베타, 감마, 델타-토코페롤이 존재한다.Tocopherol is also known as vitamin E. The substance on which vitamin E works is tocol, i.e. 2-methyl-2- [trimethyl-tridecyl] -6-hydroxychroman (2-methyl-2 [trimethyl) -tridecyl] -6-hydroxychromane) as a basic skeleton. The side chain of tocopherol is derived from phytol, and trienol having a double bond at 3 ', 7' and 11 'positions of the side chain has a structure similar to tocol. Tocols and trienols are various isomers due to the position and number of methyl groups in the chroman ring. Tocopherol species include alpha, beta, gamma and delta-tocopherol.
토코페롤은 항산화 작용이 있으며 생체 내에서 비타민 A의 산화를 방지하는 작용이 있다. 또한, 치주염 예방 효과를 위하여 치약에도 이용된다. 토코페롤 이성질체의 항산화 작용은 실온 하에서 알파:베타:감마:델타=1:1.3:1.8:2.7의 비율로 델타 토코페롤이 우수하다. 토코페롤 자체는 불안정하여 그 유도체를 많이 사용하게 되는데 특히 비타민 아세테이트, 비타민 팔미테이트 등 여러 종류의 유도체가 존재한다.Tocopherol has antioxidant activity and prevents the oxidation of vitamin A in vivo. It is also used in toothpaste for the prevention of periodontitis. The antioxidant activity of the tocopherol isomer is superior to delta tocopherol in a ratio of alpha: beta: gamma: delta = 1: 1.3: 1.8: 2.7 at room temperature. Tocopherol itself is unstable and uses a lot of its derivatives, especially vitamin acetate, vitamin palmitate and various derivatives exist.
본 발명에서는 화학적 물성이 불안정하여 변색이 심한 프로폴리스와 피부나 잇몸, 체내에서 침투속도가 낮은 토코페롤을 유상의 활성 물질을 포집하여 안정화 시킬 수 있는 나노스피어 조성물로써 제공하는데 그 목적이 있다.In the present invention, it is an object of the present invention to provide a propolis and a severe discoloration due to unstable chemical properties and tocopherols having a low penetration rate in the skin or gums, the body as a nanosphere composition capable of collecting and stabilizing an oily active substance.
또한, 본 발명의 목적은 나노스피어에 의해 안정화된 프로폴리스와 토코페롤 에멀젼을 함유하는 식품, 화장품, 치약, 생활용품을 제공하는 것이다.It is also an object of the present invention to provide food, cosmetics, toothpaste, and daily necessities containing propolis and tocopherol emulsions stabilized by nanospheres.
도 1은 나노스피어의 모식도이고,1 is a schematic diagram of nanospheres,
도 2는 본 발명에 따라 제조된 나노스피어의 입자분포를 나타낸 그래프이며,2 is a graph showing the particle distribution of the nanospheres prepared according to the present invention,
도 3은 본 발명에 따라 제조된 나노스피어의 동결 전자현미경 사진이다.3 is a frozen electron micrograph of the nanospheres prepared according to the present invention.
이하, 본 발명을 상세히 설명하면 다음과 같다.Hereinafter, the present invention will be described in detail.
본 발명은 포화 레시친 1 내지 5중량%, 에탄올 1 내지 10.0중량%, 카프릭/카프릴릭 트리글리세라이드 1 내지 10.0중량%, 프로폴리스 1 내지 10.0중량%, 토코페롤 유도체 5 내지 30중량%, 수산화나트륨 0.01 내지 0.05중량%, 이디티에이 0.01 내지 0.10중량%, 소듐아스코빌포스페이트 0.01 내지 0.05중량%, BHT 0.1 내지 0.5중량% 및 정제수로 전체 중량을 100중량%로 조절하는 것으로 이루어지는 것을 특징으로 하는 프로폴리스와 토코페롤을 함유하는 나노스피어 조성물인 것이다.The present invention is 1 to 5% by weight of saturated lecithin, 1 to 10.0% by weight of ethanol, 1 to 10.0% by weight of capric / caprylic triglyceride, 1 to 10.0% by weight of propolis, 5 to 30% by weight of tocopherol derivatives, sodium hydroxide Propolis comprising 0.01 to 0.05% by weight, ID to 0.01 to 0.10% by weight, sodium ascorbyl phosphate 0.01 to 0.05% by weight, BHT 0.1 to 0.5% by weight and purified water to 100% by weight It is a nanosphere composition containing tocopherol.
이하, 본 발명을 더욱 상세히 설명하면 다음과 같다.Hereinafter, the present invention will be described in more detail.
본 발명에 따르면, 포화 레시친 1 내지 5중량%, 에탄올 1 내지 10.0중량%,카프릭/카프릴릭 트리글리세라이드 1 내지 10.0중량%, 프로폴리스 1 내지 10.0 중량%, 토코페롤 유도체 5 내지 30중량%, 수산화나트륨 0.01 내지 0.05중량%, 이디티에이 0.01 내지 0.10중량%, 소듐아스코빌포스페이트 0.01 내지 0.05중량%, BHT 0.1 내지 0.5중량%에 정제수를 전체 조성물의 중량 100중량%가 되도록 첨가하여 교반 하에서 혼합한다. 상기 혼합물을 고압 미세 균질기를 통과시킨 후 냉각하고 탈포하여 프로폴리스와 토코페롤을 함유하는 나노스피어 조성물을 제조한다.According to the invention, 1 to 5% by weight of saturated lecithin, 1 to 10.0% by weight of ethanol, 1 to 10.0% by weight of capric / caprylic triglyceride, 1 to 10.0% by weight of propolis, 5 to 30% by weight of tocopherol derivatives, To 0.01 to 0.05% by weight of sodium hydroxide, 0.01 to 0.10% by weight of IDT, 0.01 to 0.05% by weight of sodium ascorbyl phosphate, and 0.1 to 0.5% by weight of BHT, purified water is added to 100% by weight of the total composition and mixed under stirring. . The mixture is passed through a high pressure micro homogenizer, cooled and degassed to prepare a nanosphere composition containing propolis and tocopherol.
본 발명에 있어서는 토코페롤 유도체로서 토코페롤 아세테이트, 토코페롤 팔미테이트 등을 사용할 수 있으며, 바람직하기로는 토코페롤 아세테이트를 사용한다.In the present invention, tocopherol acetate, tocopherol palmitate, and the like can be used as the tocopherol derivative, and tocopherol acetate is preferably used.
도 1에는 모노레이어를 형성하는 일반적인 나노스피어를 간략하게 도형화하여 나타내었다. 도 1에 나타난 바와 같이 나노스피어는 그 내부에 유상의 활성 물질을 포집하여 안정화시킬 수 있다.Figure 1 is a simplified illustration of the general nanospheres forming a monolayer. As shown in Figure 1, the nanospheres can be stabilized by trapping an oily active material therein.
도 2는 본 발명에 따라 제조된 나노스피어의 입자 분포를 Malvern Zetasizer 1000HS로 측정하여 나타낸 그래프로써 도 2에서 보이는 바와 같이 본 발명에 따르면 직경 200 내지 300 nm인 나노스피어가 얻어질 수 있다. 도 3은 동결 전자현미경(Freeze Fracture Scanning Electron Microscopy)을 이용하여 측정된 본 발명에 따라 제조된 나노스피어의 입자 사진이다. 나노스피어는 입자 크기가 너무 미세하여 일반적인 광학 현미경으로는 측정이 불가능한데, 동결 전자현미경 사진에서 동그랗게 된 부분이 모노레이어 부분으로 이 부분은 나노스피어가 생성되었음을 나타낸다.Figure 2 is a graph showing the particle distribution of the nanospheres prepared according to the present invention by Malvern Zetasizer 1000HS as shown in Figure 2 can be obtained according to the present invention nanospheres with a diameter of 200 to 300 nm. 3 is a photograph of particles of nanospheres prepared according to the present invention measured using Freeze Fracture Scanning Electron Microscopy. The nanospheres are so small that they cannot be measured with a conventional optical microscope. The rounded part of the frozen electron micrograph shows the monolayer part, which indicates that the nanosphere was produced.
본 발명의 나노스피어는 직경이 200 내지 300 nm의 입자 크기를 가지므로 세포간 지질 사이가 200 내지 300 nm인 피부와 잇몸 속으로 침투가 용이하여 조직 세포 내로 빠르게 침투될 수 있다.Since the nanospheres have a particle size of 200 to 300 nm in diameter, the nanospheres can easily penetrate into tissue cells due to easy penetration into skin and gums having an intercellular lipid between 200 and 300 nm.
본 발명에 따른 나노스피어 조성물은 프로폴리스와 토코페롤의 피부 또는 체내로의 흡수 투과율을 증진시켜서 이들 화합물의 생체이용률을 증가시키므로, 식품, 화장품, 생활용품, 바람직하게는 치약 등에 유용하게 이용될 수 있다.Since the nanosphere composition according to the present invention increases the bioavailability of these compounds by enhancing the absorption permeability of propolis and tocopherol into the skin or body, it can be usefully used in food, cosmetics, household goods, preferably toothpaste, and the like. .
이하, 실시예에 의하여 본 발명을 더욱 상세히 설명하면 다음과 같다. 하기의 실시예는 본 발명을 예시하기 위한 것으로, 본 발명이 다음 실시에에 의하여 제한되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to the following Examples. The following examples are intended to illustrate the present invention, and the present invention is not limited by the following examples.
실시예 1 프로폴리스와 토코페롤 아세테이트를 이용한 나노스피어Example 1 Nanospheres with Propolis and Tocopherol Acetate
하기한 성분들로 이루어진 혼합물에 정제수를 전체 조성물의 중량이 100 중량%가 되도록 첨가하여 교반 하에서 혼합하였다. 이 혼합물을 고압 미세 균질기를 통과시킨 후 냉각하고 탈포하여서 프로폴리스와 토코페롤을 함유하는 나노스피어 조성물을 제조하였다.Purified water was added to the mixture of the following components so that the weight of the total composition was 100% by weight and mixed under stirring. The mixture was passed through a high pressure micro homogenizer, cooled and degassed to prepare a nanosphere composition containing propolis and tocopherol.
성 분ingredient 함량(중량%)Content (% by weight)
포화 레시친 1 내지 5Saturated lecithin 1 to 5
에탄올 1 내지 10Ethanol 1 to 10
카프릭/카프릴릭 트리글리세라이드 1 내지 10Capric / Caprylic Triglycerides 1 to 10
프로폴리스 1 내지 10Propolis 1 to 10
토코페롤 아세테이트 5 내지 30Tocopherol acetate 5-30
수산화나트륨 0.01 내지 0.05Sodium hydroxide 0.01-0.05
이디티에이 0.01 내지 0.1IDT 0.01 to 0.1
소듐아스코빌포스페이트 0.01 내지 0.05Sodium Ascorbyl Phosphate 0.01-0.05
BHT 0.1 내지 0.5BHT 0.1 to 0.5
정제수 100중량%까지Up to 100% by weight of purified water
제조예 1크림제의 제조 Preparation Example 1 Preparation of Cream
하기한 성분들 중에서 오일에 용해되는 성분을 유상 성분으로 하고 정제수에 용해되는 성분을 수상 성분으로 하여 일정 온도(70 내지 75℃)에서 수상 성분과 유상 성분을 일반 호모믹서로 균질 혼합하는 유화 공정을 실시하였다. 유화된 혼합물을 냉각한 후에 50℃에서 카보머를 첨가하고 중화한 다음 냉각하여 온도가 30℃에 이르면 상기 실시예 1에서 제조된 나노스피어를 첨가한 후, 냉각 탈포시켜서 크림제를 제조하였다.Among the components described below, an oil phase component is used as an oil phase component, and an aqueous phase component is used as a component dissolved in purified water as an aqueous phase component. Was carried out. After cooling the emulsified mixture, carbomer was added at 50 ° C., neutralized, and cooled to reach a temperature of 30 ° C., followed by addition of the nanospheres prepared in Example 1, followed by cooling and defoaming to prepare a cream.
성 분ingredient 함량(중량%)Content (% by weight)
솔비탄 스테아레이트/수크로스 코코에이드 4.00Sorbitan Stearate / Sucrose Cocoade 4.00
스테아린산 0.80Stearic Acid 0.80
마카다미아넛 오일 7.0Macadamia Nut Oil 7.0
수쿠알란 7.0Sukualan 7.0
카프릭/카프릴릭 트리글리세라이드 7.0Capric / Caprylic Triglycerides 7.0
디메치콘 0.5Dimethicone 0.5
글리세린 5.0Glycerin 5.0
카보머 0.2Carbomer 0.2
수산화나트륨 0.01Sodium Hydroxide 0.01
나노스피어 10.0Nanosphere 10.0
정제수 100중량%까지Up to 100% by weight of purified water
제조예 2로션제의 제조 Preparation Example 2 Preparation of Lotion Agent
하기한 성분들을 사용한 것을 제외하고, 제조예 1의 방법에 따라 로션제를 제조하였다.A lotion was prepared according to the method of Preparation Example 1, except that the following ingredients were used.
성 분ingredient 함량(중량%)Content (% by weight)
폴리 글리세린-3-메칠글루코스 디스테아레이트 2.0Polyglycerin-3-Methylglucose Distearate 2.0
세테아릴알코올 0.50Cetearyl Alcohol 0.50
호호바유 6.0Jojoba 6.0
하이드로게네니트이소부탄 6.0Hydrogenite isobutane 6.0
해바라기유 4.0Sunflower oil 4.0
디메치콘 0.03Dimethicone 0.03
1,3-부칠렌글리콜 7.01,3-butylene glycol 7.0
카보머 0.10Carbomer 0.10
수산화칼륨 0.01Potassium Hydroxide 0.01
나노스피어 10.0Nanosphere 10.0
정제수 100중량%까지Up to 100% by weight of purified water
제조예 3스킨제의 제조 Preparation Example 3 Preparation of Skin Agent
상기 실시예 1에서 제조된 나노스피어 5.0 내지 10.0중량%를 취하여 정제수 90 내지 95중량%를 첨가하여 현탁액 상태의 스킨제를 제조하였다.5.0 to 10.0% by weight of the nanospheres prepared in Example 1 were taken, and 90 to 95% by weight of purified water was added thereto to prepare a skin preparation in suspension.
제조예 4치약의 제조 Preparation Example 4 Preparation of Toothpaste
일불소인산나트륨, 소듐 벤조에이트, 폴리솔비탄 80, 아세설팜 칼륨을 하기한 양으로 취하여 정제수에 첨가한 후 70 내지 75℃에서 20분간 교반하여 분체를 완전 용해하여서 치약 기재를 제조하여 상온으로 냉각하였다. 솔비톨, 글리세린, 소듐 사카린 및 상기 실시예 1에서 제조된 나노스피어를 25 내지 35℃의 상기한 치약 기재에 첨가한 후 15분간 교반 혼합하여 용해하였다.Sodium monofluorophosphate, sodium benzoate, polysorbitan 80, and acesulfame potassium were added in the following amounts and added to purified water, followed by stirring at 70 to 75 ° C. for 20 minutes to completely dissolve the powder to prepare a toothpaste base material at room temperature. Cooled. Sorbitol, glycerin, sodium saccharin and the nanospheres prepared in Example 1 were added to the toothpaste base at 25 to 35 ° C., followed by stirring for 15 minutes to dissolve.
25 내지 35℃에서 점성 실리카, 카르복시 메틸셀룰로스, 탄산칼슘을 혼합해서 상기한 공정에서 얻어진 혼합물에 단계적으로 투입한 후 폼제로서 라우릴 황산나트륨을 혼합하고 25 내지 35℃의 온도 하에 1차 탈포를 40분 이내에 완료한다. 여기에 향료를 혼합하여 2차 탈포하여서 치약을 제조하였다.Viscous silica, carboxy methylcellulose, and calcium carbonate were mixed at 25 to 35 DEG C and gradually added to the mixture obtained in the above process. Sodium lauryl sulfate was mixed as a foaming agent, and the first defoaming was carried out at a temperature of 25 to 35 DEG C for 40 minutes. Will be completed within one week. Toothpaste was prepared by mixing the perfume and degassing the secondary.
성 분ingredient 함량(중량%)Content (% by weight)
일불소인산나트륨 0.76Sodium monofluorophosphate 0.76
소듐 벤조에이트 0.20Sodium benzoate 0.20
폴리솔비탄 80 0.26Polysorbitan 80 0.26
아세설팜 칼륨 0.01Acesulfame Potassium 0.01
솔비톨 25.0Sorbitol 25.0
글리세린 0.50Glycerin 0.50
소듐 사카린 0.30Sodium Saccharin 0.30
나노스피어 1 내지 5Nanospheres 1-5
탄산칼슘 41.5Calcium Carbonate 41.5
점성 실리카 2.5Viscous Silica 2.5
카르복시 메틸셀룰로스 1.5Carboxy Methylcellulose 1.5
라우릴 황산나트륨 1.5Sodium Lauryl Sulfate 1.5
향 적량Incense
정제수Purified water
본 발명에 따르면 화학적 물성이 불안정하여 쉽게 변색을 일으키는 프로폴리스와 피부 조직 내로의 침투력이 낮은 토코페롤을 나노스피어에 의해 포집하여 안정화시켜 안정성과 피부 침투력을 증가시킨다.According to the present invention, tocopherols having low penetrability into propolis and skin tissues that easily discolor due to unstable chemical properties are collected and stabilized by nanospheres to increase stability and skin penetration.
본 발명의 프로폴리스와 토코페롤을 함유하는 나노스피어 조성물은 식품, 화장품, 생활용품 바람직하게는 치약에 사용되어 프로폴리스와 토코페롤의 생체내 이용률을 증가시킬 수 있다.The nanosphere composition containing the propolis and tocopherol of the present invention can be used in food, cosmetics, household goods, preferably toothpaste, to increase the bioavailability of propolis and tocopherol.
Claims (5)
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| KR100489267B1 (en) * | 2002-11-27 | 2005-05-17 | 유효경 | Oral care composition comprising nanoparticulated cinnamon extract |
| CN101731506B (en) * | 2009-12-15 | 2013-01-09 | 白万军 | Health-care food of bee glue and wood frog lecithin capsule |
| KR101410042B1 (en) * | 2012-05-31 | 2014-06-27 | 청운대학교산학협력단 | Composition of moisturizing cosmetics containing propolis nano-vesicle |
| US11779539B2 (en) | 2018-04-17 | 2023-10-10 | Astin Co., Ltd. | Non-surfactant type oil-water dispersion composition, non-surfactant type water-oil dispersion composition, and manufacturing methods for both compositions |
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