KR20040028437A - 바이오 센서의 시료 반응결과 측정장치 및 그 방법 - Google Patents
바이오 센서의 시료 반응결과 측정장치 및 그 방법 Download PDFInfo
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- KR20040028437A KR20040028437A KR1020020059612A KR20020059612A KR20040028437A KR 20040028437 A KR20040028437 A KR 20040028437A KR 1020020059612 A KR1020020059612 A KR 1020020059612A KR 20020059612 A KR20020059612 A KR 20020059612A KR 20040028437 A KR20040028437 A KR 20040028437A
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- South Korea
- Prior art keywords
- biosensor
- electrode
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- value
- Prior art date
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 36
- 238000000034 method Methods 0.000 claims abstract description 13
- 238000001514 detection method Methods 0.000 claims description 11
- 239000000376 reactant Substances 0.000 abstract description 4
- 239000000523 sample Substances 0.000 description 48
- 239000000758 substrate Substances 0.000 description 19
- 238000006911 enzymatic reaction Methods 0.000 description 14
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 238000005259 measurement Methods 0.000 description 10
- 239000000370 acceptor Substances 0.000 description 9
- 239000012472 biological sample Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 125000006850 spacer group Chemical group 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 229940088598 enzyme Drugs 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 108010015776 Glucose oxidase Proteins 0.000 description 6
- 239000004366 Glucose oxidase Substances 0.000 description 6
- 229940116332 glucose oxidase Drugs 0.000 description 6
- 235000019420 glucose oxidase Nutrition 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 238000007650 screen-printing Methods 0.000 description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 239000000976 ink Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000012212 insulator Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- OZZQHCBFUVFZGT-UHFFFAOYSA-N 2-(2-hydroxypropanoyloxy)propanoic acid Chemical compound CC(O)C(=O)OC(C)C(O)=O OZZQHCBFUVFZGT-UHFFFAOYSA-N 0.000 description 1
- 108010073450 Lactate 2-monooxygenase Proteins 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000013208 measuring procedure Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229920005668 polycarbonate resin Polymers 0.000 description 1
- 239000004431 polycarbonate resin Substances 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
분석물질 | 효소 |
포도당 | Glucose oxidase |
콜레스테롤 | Cholesterol esteraseCholesterol oxidasePeroxinase |
크레아티닌 | CreatininaseCreatinaseSarcosine oxidase |
젖산 | Lactate oxidase |
Claims (3)
- 두 개의 작동전극과 하나의 기준전극을 포함하는 바이오 센서의 시료 반응결과 측정방법에 있어서,상기 작동전극 각각에 순차적으로 전원을 공급하는 단계와;전원공급에 따라 상기 작동전극을 흐르는 전류량을 순차 검출하는 단계와;두 작동전극 각각에 전원을 재공급하여 각각의 작동전극을 흐르는 전류량을 재검출하는 단계와;검출된 각각의 전류량에 대응하는 농도값을 메모리로부터 리드하여 평균치 산출하는 단계와;상기 메모리로부터 리드된 농도값 각각이 상기 평균치와 미리 정해진 임계치 이상 벗어나는 가를 검사하여 에러 표시하거나 산출된 평균치를 표시하는 단계;를 포함함을 특징으로 하는 바이오 센서의 시료 반응결과 측정방법.
- 청구항 1에 있어서, 최초 전원공급에 따라 상기 제1작동전극의 전류검출시점부터 제2작동전극의 전류검출시점까지의 시간과 각각의 검출 전류량으로 에러발생 여부를 판단하는 단계와;에러발생시 이를 표시하는 단계;를 더 포함함을 특징으로 하는 바이오 센서의 시료 반응결과 측정방법.
- 두 개의 작동전극과 기준전극을 포함하는 바이오 센서의 시료 반응결과를 측정하는 장치에 있어서,전압원이 비반전 단자에 접속되어 있고 반전단자에 일측이 접속된 스위치를 통해 상기 작동전극 각각을 흐르는 전류량을 검출하여 전압값으로 출력하는 하나 이상의 연산 증폭기들과;결합되는 바이오 센서의 기준전극을 접지시키기 위한 제2스위치와;결합되는 바이오 센서의 작동전극 하나를 접지시키기 위한 제3스위치와;시료 반응결과 및 에러상태를 표시하기 위한 표시부와;상기 스위치들을 제어하여 두 작동전극 각각에 전원을 공급하여 시료의 전극도달상태 여부를 검사한후 상기 스위치들을 제어하여 두 작동전극에 전원을 각각 재공급하여 검출된 전압값에 대응하는 농도값을 리드하여 평균치 산출후, 산출된 평균치와 각 농도값을 비교하여 에러발생 여부 혹은 산출된 평균치를 표시하는 마이크로 프로세서;를 포함함을 특징으로 하는 바이오 센서의 시료 반응결과 측정장치.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2002-0059612A KR100485671B1 (ko) | 2002-09-30 | 2002-09-30 | 바이오 센서의 시료 반응결과 측정장치 및 그 방법 |
AU2002349499A AU2002349499A1 (en) | 2002-09-30 | 2002-10-04 | Apparatus and method for measuring reaction result of samples on biosensor |
CNB028296575A CN1302281C (zh) | 2002-09-30 | 2002-10-04 | 用于测定生物传感器上样品的反应结果的设备和方法 |
EP02781908A EP1565732A4 (en) | 2002-09-30 | 2002-10-04 | DEVICE AND METHOD FOR MEASURING THE RESPONSE RESULT OF SAMPLES ON A BIOSENSOR |
US10/528,187 US7678261B2 (en) | 2002-09-30 | 2002-10-04 | Apparatus and method for measuring reaction result of samples on biosensor |
PCT/KR2002/001853 WO2004029605A1 (en) | 2002-09-30 | 2002-10-04 | Apparatus and method for measuring reaction result of samples on biosensor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2002-0059612A KR100485671B1 (ko) | 2002-09-30 | 2002-09-30 | 바이오 센서의 시료 반응결과 측정장치 및 그 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040028437A true KR20040028437A (ko) | 2004-04-03 |
KR100485671B1 KR100485671B1 (ko) | 2005-04-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-2002-0059612A KR100485671B1 (ko) | 2002-09-30 | 2002-09-30 | 바이오 센서의 시료 반응결과 측정장치 및 그 방법 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7678261B2 (ko) |
EP (1) | EP1565732A4 (ko) |
KR (1) | KR100485671B1 (ko) |
CN (1) | CN1302281C (ko) |
AU (1) | AU2002349499A1 (ko) |
WO (1) | WO2004029605A1 (ko) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100801905B1 (ko) * | 2005-08-08 | 2008-02-12 | 주식회사 인포피아 | 바이오 센서의 시료 반응결과 측정장치 및 그 방법 |
WO2010140769A3 (ko) * | 2009-06-04 | 2011-01-20 | 주식회사 인포피아 | 재현성 향상을 위한 알고리즘을 사용하는 생체 데이터 측정장치 및 생체 데이터 측정방법 |
KR101165200B1 (ko) * | 2006-11-10 | 2012-07-17 | 주식회사 인포피아 | 바이오센서 |
US9044756B2 (en) | 2005-09-16 | 2015-06-02 | Infopia Co., Ltd. | Apparatus for reading identification information of biosensor |
Families Citing this family (12)
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DE10397018A5 (de) | 2002-07-02 | 2015-05-28 | Panasonic Healthcare Holdings Co., Ltd. | Biosensor, Biosensorchip und Biosensoreinrichtung |
JP3910148B2 (ja) * | 2003-03-14 | 2007-04-25 | アークレイ株式会社 | 排気口付き分析用具 |
KR101092350B1 (ko) * | 2003-10-31 | 2011-12-09 | 라이프스캔 스코트랜드 리미티드 | 2개의 다른 인가전위들을 이용한 전기화학 센서에서의 간섭감소 방법을 사용하는 계량기 |
US7655119B2 (en) | 2003-10-31 | 2010-02-02 | Lifescan Scotland Limited | Meter for use in an improved method of reducing interferences in an electrochemical sensor using two different applied potentials |
DE102004002289B4 (de) * | 2004-01-16 | 2007-02-22 | Dräger Safety AG & Co. KGaA | Gasmessgerät mit einem elektrochemischen Sensor |
US7569126B2 (en) * | 2004-06-18 | 2009-08-04 | Roche Diagnostics Operations, Inc. | System and method for quality assurance of a biosensor test strip |
US8496801B2 (en) | 2005-07-26 | 2013-07-30 | Bayer Healthcare Llc | Method and system for checking an electromechanical biosensor |
US8066866B2 (en) * | 2005-10-17 | 2011-11-29 | Lifescan, Inc. | Methods for measuring physiological fluids |
GB201420982D0 (en) * | 2014-11-26 | 2015-01-07 | Inside Biometrics Ltd | Verifying operation of a meter |
US20160178561A1 (en) * | 2014-12-17 | 2016-06-23 | Lifescan Scotland Limited | Hand-held test meter with test strip electrode to ground-reference switch circuit block |
TWI589869B (zh) * | 2016-08-08 | 2017-07-01 | 友達光電股份有限公司 | 感測裝置及該感測裝置之電極試片 |
CN108132284B (zh) * | 2017-12-26 | 2019-11-29 | 三诺生物传感股份有限公司 | 一种电化学传感器的测试方法 |
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-
2002
- 2002-09-30 KR KR10-2002-0059612A patent/KR100485671B1/ko active IP Right Grant
- 2002-10-04 EP EP02781908A patent/EP1565732A4/en not_active Withdrawn
- 2002-10-04 US US10/528,187 patent/US7678261B2/en active Active
- 2002-10-04 AU AU2002349499A patent/AU2002349499A1/en not_active Abandoned
- 2002-10-04 CN CNB028296575A patent/CN1302281C/zh not_active Expired - Lifetime
- 2002-10-04 WO PCT/KR2002/001853 patent/WO2004029605A1/en not_active Application Discontinuation
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100801905B1 (ko) * | 2005-08-08 | 2008-02-12 | 주식회사 인포피아 | 바이오 센서의 시료 반응결과 측정장치 및 그 방법 |
US7897033B2 (en) | 2005-08-08 | 2011-03-01 | Infopia Co., Ltd. | Method and apparatus for measuring sample reaction results on biosensor |
US8702923B2 (en) | 2005-08-08 | 2014-04-22 | Infopia Co., Ltd. | Method and apparatus for measuring sample reaction results on biosensor |
US9044756B2 (en) | 2005-09-16 | 2015-06-02 | Infopia Co., Ltd. | Apparatus for reading identification information of biosensor |
US9180458B2 (en) | 2005-09-16 | 2015-11-10 | Infopia Co., Ltd. | Biosensor having identification information and apparatus for reading identification information of biosensor |
KR101165200B1 (ko) * | 2006-11-10 | 2012-07-17 | 주식회사 인포피아 | 바이오센서 |
WO2010140769A3 (ko) * | 2009-06-04 | 2011-01-20 | 주식회사 인포피아 | 재현성 향상을 위한 알고리즘을 사용하는 생체 데이터 측정장치 및 생체 데이터 측정방법 |
KR101100620B1 (ko) * | 2009-06-04 | 2012-01-03 | 주식회사 인포피아 | 재현성 향상을 위한 알고리즘을 사용하는 생체 데이터 측정장치 및 생체 데이터 측정방법 |
US9307937B2 (en) | 2009-06-04 | 2016-04-12 | Infopia Co., Ltd. | Apparatus and method for measuring biomedical data using algorithm for improving reproducibility |
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KR100485671B1 (ko) | 2005-04-27 |
US7678261B2 (en) | 2010-03-16 |
CN1302281C (zh) | 2007-02-28 |
EP1565732A1 (en) | 2005-08-24 |
US20060163086A1 (en) | 2006-07-27 |
WO2004029605A1 (en) | 2004-04-08 |
CN1668916A (zh) | 2005-09-14 |
EP1565732A4 (en) | 2008-12-17 |
AU2002349499A1 (en) | 2004-04-19 |
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