KR20040024213A - Non-woven fabric pack impregnated with crude saponin of red ginseng for the improvement of acne - Google Patents

Abstract

PURPOSE: Provided is a nonwoven fabric pack which contains crude saponin extracted from red ginseng, and prevents and treats acnes in convenient and effective manners. CONSTITUTION: The acne treatment nonwoven fabric pack comprises a pack formed with nonwoven fabric, and a crude saponin composition impregnated into the pack. The crude saponin composition is prepared by the steps of: dissolving 0.03-0.07wt.% of crude saponin extracted from red ginseng, 0.05-0.3wt.% of allantoin and 7.0-12.0wt.% of glycerin in 85-95wt.% of purified water at 55-65 deg.C; adding 0.04-0.08wt.% of carbomer to the solution; lowering the temperature thereof to 40 deg.C; dissolving 0.06wt.% of triethanolamine in the mixed solution; and drying it.

Description

Non-woven fabric pack impregnated with crude saponin of red ginseng for the improvement of acne}

The present invention relates to a non-woven fabric pack containing red ginseng irradiated with the main component is effective in improving acne. More specifically, the present invention is based on the finding that the red ginseng irradiated saponinin, which is known to have a cosmetic effect, is applied to a nonwoven fabric to inhibit and treat acne. It can be characterized by.

Acne is a symbol of puberty, and 70 to 80% of men and women are experiencing puberty. Recently, many men and women in their twenties and thirties experience acne for the first time due to stress caused by work life. The causes of such acne include the overproduction of the first sebum and the closure of the second pores. Third causes include propionibacterium acnes and Staphylococcus epidermidis , which are anaerobic bacteria that grow as sebum components accumulate in black or clumps of black melanin. The propionibacterium acne is an anaerobic bacterium mainly distributed around the pores or the nipples, and it is proliferated by sebum as a nutrient to secrete lipase to decompose triglyceride which is the main component of sebum to make free fatty acids. Fatty acids act on the skin epithelium to produce a variety of enzymes and destroy the hair follicle walls, causing inflammation in the connective tissue around the hair follicles.

Other causes of acne are not yet clear, but genetic and endocrine disorders, particularly thyroid gland, pituitary gland, abnormalities in sex hormone balance and digestive disorders, and excessive intake of fat and sugar have been pointed out as causes.

Because of these various causes, the process of keratinizing the epidermal cells near the sweat pores is abnormally progressed, and if the keratinization is too severe, these pores are blocked and fat is not discharged to the skin, which is caused to protrude over the skin.

Conventional acne treatment relies on antibiotics that kill Propionibacterium acne or methods for suppressing sebum oversecretion. Existing drugs for this treatment include tetracycline, minocycline, and deoxycycline. (deoxycycline), erythromycine, cilindamycine, isotrethionine, trethionine, cyprotetrone acetate and spirolactone have been reported to be therapeutic have. In addition to the above drugs, about 40 candidate drug candidates are currently being developed, and about 16 are mainly being focused on research on retinoids and androgen antagonists.

However, despite the development of a therapeutic agent as described above, acne treatment is not fundamental, and frequent recurrences and side effects, such as the cause of the problem, the treatment is performed in a fragmentary and temporary, one cause can be found, in the case of acne It is a disease that requires a long period of treatment and effort, but there are many difficulties in taking and applying the various drugs listed above for several months and accompanied by many side effects.

On the other hand, ginseng has a skin cosmetic effect has been introduced in the "agreement bogam", "pharmaceutical combination", etc. from the old days, recently applied to cosmetics, such as lotions, creams, shampoos, soaps have been commercialized a lot of products . Ginseng saponin was combined with phospholipids and physicochemically and applied to cosmetics to give moisture and flexibility to the skin. In addition, red ginseng has been reported to be effective in removing acne by conducting research on the efficacy of acne and skin diseases of red ginseng.

Red ginseng saponin is called ginsenoside, which is a pharmacological action among various active ingredients of red ginseng. It has excellent effect on preventing aging and moisturizes skin to replace the gelatin used as a conventional skin moisturizer. Is known to be excellent. In addition, the anti-inflammatory effect of red ginseng is known.

Therefore, when the application and development of the acne improvement effect of the beneficial effects of the red ginseng as described above as an acne treatment aid formulation, it was expected to create a lot of demand for many people who suffered and suffered from acne. Lotion, ointment, and cosmetics can be used as a supplement for acne treatment.However, in the sense that the saponin component of red ginseng is impregnated with a nonwoven fabric, it is easy to use and has no side effects even after long use. It could be an alternative.

Accordingly, an object of the present invention is to provide a non-woven fabric pack for improving acne as a non-woven fabric pack containing irradiated saponin of red ginseng as a main ingredient, which can be an excellent alternative as an auxiliary treatment for acne.

In addition, the non-woven fabric pack of the present invention, unlike conventional ointments, so it is easy to use a pack form, it is an object of the present invention to provide a non-woven pack for improving acne that provides excellent convenience, such as no side effects even in long-term use.

It is another object of the present invention to provide a nonwoven fabric pack containing red ginseng checkonin having an acne improving effect, thereby providing an alternative as an auxiliary therapeutic agent for acne.

In order to achieve the above object, the present invention is characterized by containing red ginseng checkonin as a main component of the pack composition.

More specifically, the non-woven fabric pack for improving acne of the present invention, from 0.03 to 0.07 parts by weight of irradiated saponinine, from 0.05 to 0.3 parts by weight of allantoin and from 7.0 to 12.0 parts by weight of glycerin from 55 to 95 parts by weight of purified water After dissolving at 65 DEG C, 0.04 to 0.08 parts by weight of carbomer is added, and then, the temperature is lowered to 40 DEG C, and 0.06 parts by weight of triethanolamine is added to dissolve, followed by drying. .

Hereinafter will be described in detail a clinical trial for testing the efficacy of the acne improvement pack containing red ginseng irradiated saponin.

0.1 parts by weight of allantoin, 0.065 parts by weight of red ginseng irradiated with red ginseng, 9.0 parts by weight of glycerin, and 90.715 parts by weight of purified water were dissolved at a temperature of 60 ° C., and then dissolved. It was lowered to 40 ℃ while dissolving triethanolamine while adding 0.06 parts by weight, the dispersion was completed when the solution state was uniform to the naked eye to complete the dispersion and then dried to obtain a pack composition containing red ginseng checkonin. The study was conducted on 20 volunteers who were diagnosed with acne who visited the university hospital dermatology by applying it to the nonwoven fabric pack.

Non-woven packs impregnated with red ginseng irradiated with pons were applied to the affected area for at least 20 minutes once daily for two weeks. Lesion improvement was assessed by subjective and objective improvement. Subjective improvement was assessed by the questionnaire about the change in the overall skin condition felt by the patient, and objective improvement was determined by erythema, comeedone, papule, and pustule, respectively. Scores of 1, 2, and 3 were added together to compare the status before and after the trial.

Of the 20 subjects, there were 15 women and 5 men, with an average age of 24.1 years (Table 1). The evaluation sites were forehead in four of the face, seven in the left and nine in the right isthmus (Table 2).

Age and gender of clinical trial subjects age male female Sum 10 to 19 One 2 3 20 to 29 4 10 14 30 to 39 - 3 3 Sum 5 15 20

Evaluation site male female Sum Forehead 0 4 4 Left Cheek 3 4 7 Right Cheek 2 7 9 Sum 5 15 20

Subjective improvement of acne improvement in non-woven packs containing red ginseng saponin Evaluation site Subjective evaluation Warfare Elasticity Person 1 Left cheek Improvement Improvement Person 2 Left cheek same Improvement Person 3 Forehead Improvement Improvement Person 4 Forehead same Improvement Person 5 Right cheek Improvement Improvement Person 6 Right cheek same Improvement Person 7 Right cheek same Improvement Person 8 Right cheek Improvement Improvement Person 9 Right cheek Improvement Improvement Person 10 Forehead Improvement Improvement Person 11 Right cheek same Improvement Person 12 Right cheek Improvement Improvement Person 13 Right cheek Improvement Improvement Person 14 Right cheek same Improvement Person15 Left cheek same Improvement Person16 Left cheek same Improvement Person17 Forehead same Improvement Person18 Left cheek Improvement Improvement Person19 Left cheek same same Person 20 Left cheek Improvement Improvement

Evaluation site: Forehead

Left cheek (left cheek)

Right cheek (right cheek)

Objective improvement scored the severity of lesions by erythema, cotton, papules and pustules, respectively, and compared the results before and after the trial.The severity of lesions in 20 subjects was 0, The scores of 1, 2, and 3 were added and the results were compared before and after the trial. The average improvement was 33.9%. The improvement of erythema, cotton, papule, and pustules was 33.3%, 4.2%, 39.4%, and 59.1%, respectively.

Improvement in acne improvement Classification Agility (%) Erythema 33.3 Cotton 4.2 Papules 39.4 Pustules 59.1 Average 33.9

As described above, it can be seen that the nonwoven fabric pack containing red ginseng irradiated saponin according to the present invention is effective in improving acne. In addition, unlike conventional ointments, it is easy to use the pack in the form of acne treatment to improve the effect can provide a great convenience even for long-term use.

Claims (1)

A non-woven fabric pack for acne improvement comprising impregnating red ginseng irradiated with a non-woven fabric pack.