KR20030022500A - Composition of healthfood for skin-whitening - Google Patents

Abstract

PURPOSE: A skin whitening health food composition containing soybean isoflavone and an extract of placenta, Phyllanthus emblica and milk thistle as a main component is provided which has an effect on improving chloasma, senile plaque and skin pigmentation caused by sun burn without causing adverse effect on a human body. CONSTITUTION: The health food composition for improving skin pigmentation contains 1 part by weight of soybean isoflavone, 1 to 10 parts by weight of a placenta extract, 0.5 to 10 parts by weight of a Phyllanthus emblica extract and 0.5 to 10 parts by weight of a milk thistle extract. The composition is formulated into a liquid, tablet, granule, pill, soft gelatin capsule and hard gelatin capsule.

Description

Composition of healthfood for skin-whitening}

The present invention relates to a skin whitening health food comprising isoflavones, placenta extracts, amla extracts, and milk thistles extracted from soybeans, and more specifically, pigments such as blemishes, senile spots and sunburns. A composition for improving the symptoms of deposition.

Pigmentation symptoms such as blemishes, senile spots and sunburn have been a serious problem for women longing for beauty and those who want to look young.

The organic compounds used to solve this problem were bleaching substances such as hydroquinone, but they were prohibited to use, and melanin was inhibited by inhibiting tyrosinase such as kojic acid (Japanese Patent Application No. 11-161155). Production inhibitors, green tea extracts or cosmetics containing antioxidants such as tocopherols and vitamin C are well known in the art.

As functional substances of conventional cosmetics that improve pigmentation symptoms appear only when they are absorbed through the skin, the effect is not sufficient because the absorption is through the skin due to the fundamental reason that the skin is excretory organs. have. Therefore, there is an urgent need to develop a product that exerts oral ingestion of a material that exhibits a whitening effect or a skin whitening effect by showing an excellent improvement effect on pigmentation symptoms.

The present inventors conducted a number of studies to develop a material and a product having a high safety without side effects and improving the pigmentation symptoms, as a result, a composition containing isoflavones, placenta extract, amla extract and milk thistle extracted from soybean The present invention was completed by confirming the excellent effect of improving the pigmentation symptoms without this side effect.

Accordingly, it is an object of the present invention to provide a pigmentation-improving agent characterized in that it contains isoflavones, placenta extracts, amra extracts and milk thistles extracted from soybeans.

Still another object of the present invention is to provide an oral dosage form for improving pigmentation, such as tablets, capsules, granules, pills, and liquids, comprising isoflavones, placenta extracts, amra extracts, and milk thistles extracted from soybeans. There is.

The present invention relates to a composition for improving pigmentation symptoms such as isoflavones, placenta extracts, amla extracts, and milk thistle extracts from soybeans, ie blemishes, senile spots and sunburn. It is about.

Facial and skin conditions are heavily influenced from inside the body. Therefore, a healthy face and skin is due to a healthy body, so it is more desirable to have both a cosmetic effect and a health effect.

Increasing the potency of the body's free teeth by improving blood circulation, promoting cell division, promoting metabolism, removing free radicals, anti-inflammatory, anti-allergic, inhibiting and removing harmful substances, and improving hormone imbalance. It should work to keep skin healthy and young and maximize the whitening effect. In order to achieve this purpose, it has been found that the desired purpose can be achieved by combining several components having respective effects due to a lack of a single component.

Bovine placenta extract has been used carefully as a vegetative medicinal herb since ancient times, and is an animal nourishment tonic herbal medicine that has been recognized for its usefulness as a medicine and cosmetic material in modern times. In addition to the three major nutrients (amino acids, proteins, lipids, sugars), placenta contains a variety of enzymes, vitamins, and minerals, as well as unique substances with mysterious powers that enhance the body's natural healing power. The specific effect is to improve blood circulation, promote skin metabolism, promote skin cell division, prevent skin inflammation from stimulation, inhibit the activity of free radicals, inhibit the production and deposition of melanin pigment, balance of autonomic nerve and hormone Enhance function by promoting long-term tissue cell regeneration such as regulation, liver, and stimulating hematopoietic tissue to accelerate hematopoietic action, wound recovery and glycogen formation, thus preventing liver cirrhosis, blemishes, freckle improvement, anemia treatment, menopausal disorder improvement, menstrual disorder It is applied to improvement of hyperthermia, weakness and sickness after illness, rehabilitation of habitual constipation, loss of energy, prevention of cancer, aging delay, increased resistance, and allergy improvement.

Amra extract is a phyllanthus emblica fruit extract, a health fruit found in Ayurveda, a traditional Indian medicine. It contains 10 times as much vitamin C as lemon and 30 times as much polyphenol as red skin. It is a new material that can be consumed in large quantities. With 5 major effects on skin and health: 1) inhibition of free radicals: anti-aging effect by preventing cell damage, 2) inhibition of decomposition of hyaluronic acid: protection of moisturizing ingredients. 3) Protection of collagen: It gives skin strength and elasticity and prevents skin aging. 4) Allergy-Inflammation Inhibition: Protects skin from trabble, 5) Free Inhibition of Histamine: It is known to alleviate allergy symptoms.

Soy isoflavone is a refined soybean extract, also known as phytoestrogens, and maintains the homeostasis of female hormone estrogen in the body, thereby improving skin and health symptoms caused by female hormone deficiency or imbalance.

Treatment and prevention of menopausal disorders, prevention and treatment of chronic diseases: Lowering blood cholesterol, arteriosclerosis, coronary artery disease suppression, anticancer, osteoporosis treatment has been clinically confirmed.

Milk Thistle is an extract of Silybum marianum, a medicinal plant that has been used as a folk medicine in Europe for more than 2000 years. It is a medicine for the treatment of liver damage caused by drug poisoning, adjuvant medicine for chronic hepatitis and cirrhosis, gallbladder, digestive system, spleen and other diseases. It is a herb widely used in tribes. Milk Thistle contains Silymarin as an active ingredient 1) Hepatocellular membrane stabilization: 50% increase in glutathione concentration in liver, synergistic superoxide dismutase activity, active oxygen by 10 times stronger antioxidant activity than vitamin E It enhances the ability to remove, adjusts receptors on the cell membrane to prevent the entry of toxic substances such as alcohol, carbon tetrachloride, toxin and various pollutants into the cell, and protects liver cells by inhibiting harmful substances such as free molecules generated during metabolism. Stabilize the cell membrane.

2) Impaired hepatocyte regeneration: Promotes RNA synthesis and protein synthesis to restore the enzymes and structural proteins of hepatocytes that have degraded due to drinking and virus infection.

Promotes regeneration of hepatocytes but does not promote cancer cell proliferation.

Alcoholic hepatitis, drug-induced liver damage, cirrhosis, environmental pollution and liver damage caused by substances in the working environment, and liver damage caused by various causes improve stomach discomfort, fatigue, nausea, discomfort and itching. Improving liver function is expected to keep your face and skin healthy and whitened.

Soy isoflavones, placenta extracts, amra extracts, and milk thistles have been used as health foods, but their compositions are used to significantly improve pigmentation symptoms such as blemishes, senile spots and sunburn. Since there was no use, the composition of the present invention is novel.

The composition of the present invention can add a whitening effect by adding components such as vitamin C, E, B group and A, zinc, iron, etc., which have the effect of improving bowel movement, such as the extract of Cassava or Cascara sagrada extract.

Hereinafter, the present invention will be described in detail.

The present invention relates to a composition for improving pigmentation symptom improvement without high side effects, characterized by containing soy isoflavones, placenta extracts, Amra extracts and milk thistle.

Soy isoflavones are preferably soybean extract containing 10 to 80% of isoflavones can be used in the market. Placenta extract is used by powdering the placenta of cows or sheep with water. Amla extract is obtained by pulverizing Phyllanthus emblica fruits with water or hydrated alcohol from 1: 1 to 7: 1. Milk Thistle is an extract of Silybum marianum, which contains 20% to 85% of silymarin.

The composition ratio of the present invention is preferably 1 to 10 weight ratio of placenta extract, 0.5 to 10 weight ratio of Amra extract, and 0.5 to 10 weight ratio of milk thistle with respect to 1 weight ratio of soy isoflavones. If necessary, oral dosage preparations such as tablets, capsules, soft capsules, granules, solutions, and pills may be prepared and consumed using additives, emulsifiers, suspending agents, pressure-sensitive adhesives, acidulants, and fragrances commonly used in oral dosage forms. Can be.

Soy isoflavones of the present invention is preferably ingested 2 to 3 times a day so that isoflavones are ingested 30 to 100mg per day.

Hereinafter, the present invention will be described in more detail based on the preferred embodiments, which are intended to aid the understanding of the present invention and are not intended to limit the scope of the present invention in any way.

EXAMPLE

Placenta extract used in the following examples are bovine placenta water extract powder (Japan), soybean extract powder is domestically 30% isoflavones, Amla extract is water extract powder concentrated to 4: 1, milk thistle silymarin 20 % And 80% of what was purchased commercially was used.

Example 1 Liquid

Placenta extract 5.2g, soy extract powder (5% isoflavone) 5g, Amla extract 2.4g, milk thistle (20% silymarin) 1.4g, vitamin C 5g, vitamin B1 hydrochloride 200mg, vitamin B2 100mg, twin 80 2g After adding to 500ml it was warmed to 50 ℃ and solubilized by stirring to prepare a liquid.

Example 2 Granules

Placenta Extract 50g, Soy Extract Powder 55g, Amla Extract 30g, Milk Thistle (Silymarin 80%) 40g, Vitamin E Powder (50%) 10g, Vitamin C 25g, Vitamin B1 Hydrochloride 1g, Vitamin B 0.8g, Nicotinic Acid Amide 5g, 1.2 g of vitamin B6 hydrochloride, 0.5 g of folic acid, 1.5 g of magnesium stearate, 2 g of zinc oxide, 2 g of iron fumarate, and 176 g of corn starch were mixed well and granules were prepared according to a conventional method.

Example 3 Tablet

The granules prepared in Example 2 were compressed into tablets according to a conventional method to prepare 500 mg tablets.

Example 4 Hard Capsule

Placenta Extract 45g, Soybean Extract Powder 50g, Amla Extract 30g, Milk Thistle (Silymarin 80%) 25g, Vitamin E Powder (50%) 50g, Vitamin C 50g, Zinc Oxide 10g, Vitamin A Acetate Powder, Magnesium Stearate 2g , 37 g of microcrystalline cellulose were mixed well, and 400 mg of the hard capsule was filled in a conventional manner to prepare a capsule.

Example 5 Pill

Placenta Extract 45g, Soy Extract Powder (Isoflavone 30%) 50g, Amla Extract 30g, Milk Thistle (Silymarin 80%) 25g, Vitamin E Powder (50%) 50g, Vitamin C 50g, Zinc Oxide 10g, Vitamin A Acetate Powder 1 g, corn starch 37 g, honey 100 g was mixed well to prepare a 100 mg pills according to a conventional method.

Example 6 Soft Capsule

Placenta Extract 517g, Soy Extract Powder (Isoflavone 30%) 495g, Amla Extract Powder 331g, Milk Thistle (Silymarin 80%) 433g, Vitamin E Acetate 363g, Vitamin C 220g, Zinc Oxide 165g, Vitamin B1 Hydrochloride 16.5g, Vitamin B2 16.5g, nicotinic acid amide 50g, vitamin B6 hydrochloride 16.5g, vitamin A acetate 3.3g, folic acid 2.2g, lecithin 55g, soybean oil 2596g, lead 110g, homogeneously mixed and filled with 550mg each according to a conventional method to produce a soft capsule It was.

Reference Example 1 Soft Capsule

Placenta Extract 517g, Vitamin E Acetate 363g, Vitamin C 220g, Zinc Oxide 165g, Vitamin B1 Hydrochloride 16.5g, Vitamin B2 16.5g, Nicotinamide 50g, Vitamin B6 Hydrochloride 16.5g, Vitamin A Acetate 3.3g, Folic Acid 2.2g, Lecithin 55g , 1259 g of crystalline cellulose, 2596 g of soybean oil, and 110 g of lead were homogeneously mixed, and 550 mg of each was filled according to a conventional method to prepare a soft capsule.

Reference Example 2 Soft Capsule

Soybean oil was filled in 550mg each to prepare a soft capsule.

Experimental Example 1 Improvement

In order to confirm the improvement effect on the blemishes of the composition of the present invention, the soft capsules prepared in Example 6, Reference Example 1, and Reference Example 2 were divided into three groups of 30 women aged 40 to 60 years with blemishes for 1 month for 2 months. Two capsules were taken twice (after breakfast and after dinner).

Experimental results were visually observed that disappearance was determined by four cases as follows, the results are shown in Table 1.

Significant effect There are no noticeable thinning or senile spots

Jean

When it is judged to be effective effectively

Slightly effective When the pigment disappears

If there is no invalid change

The effective rate was taken as the ratio which a little more than effective.

The composition containing the placenta extract, soy isoflavone, Amla extract and milk thistle according to the present invention showed a synergistically high improvement effect of 90% against the blemishes.

[Table 1] Blemish Treatment Effect

Experimental Example 2 Improvement of Geriatric Spots

Thirty 60-80 year old women with senile spots were administered in the same manner as in Experiment 1 for 2 months and the results are shown in Table 2.

[Table 2] Improvement of Geriatric Spots

As shown in the experimental example, the composition of the present invention exhibits an excellent improvement effect at 90% effective rate, 80% effective rate for blemishes, and can be used as a dietary supplement that is expected to improve skin pigmentation due to sunburn.

The composition of the present invention exhibits a significant improvement over the placenta extract, which is known to have a blemish-improving effect, by adding soy isoflavone, amarula extract, and milk thistle, which act as female hormones to the placenta extract, thereby exerting a synergistic effect. It is thought to improve pigmentation symptoms such as blemishes and senile spots.

In addition, while taking the composition of the present invention, no symptoms thought to be adverse effects were found to be very safe enough to be widely used as a health food.

Claims (4)

A pigmentation improver composition comprising as a active ingredient a placenta extract, soy isoflavone, amra extract and milk thistle. The composition ratio of claim 1, wherein the composition ratio is 1 to 10% by weight based on 1 weight ratio of soy isoflavone, 0.5 to 10% by weight of Amla extract, and 0.5 to 10% by weight of milk thistle. . Pigmentation improving composition according to claim 1, wherein the pigmentation is blemishes and senile plaques. The pigmentation-improving agent composition according to claim 1, wherein the formulation is liquid, tablet, granule, pill, soft capsule, hard capsule.